locus-tag	class	description
CHX26_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHX26_RS00015	COG0322	excinuclease ABC activity
CHX26_RS00025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CHX26_RS00030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHX26_RS00040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CHX26_RS00050	COG1301	dicarboxylic acid transport
CHX26_RS00055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHX26_RS00070	COG0625	glutathione transferase activity
CHX26_RS00105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CHX26_RS00110	COG0706	membrane insertase activity
CHX26_RS00115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CHX26_RS00120	COG0594	ribonuclease P activity
CHX26_RS00125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CHX26_RS00155	COG0514	ATP-dependent DNA helicase (RecQ)
CHX26_RS00175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHX26_RS00190	COG2866	Carboxypeptidase
CHX26_RS00210	COG5328	Belongs to the UPF0262 family
CHX26_RS00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHX26_RS00230	COG1758	RNA polymerase activity
CHX26_RS00235	COG1192	Involved in chromosome partitioning
CHX26_RS00255	COG1309	transcriptional regulator
CHX26_RS00265	COG1136	(ABC) transporter
CHX26_RS00265	COG0577	efflux transmembrane transporter activity
CHX26_RS00280	COG2030	dehydratase
CHX26_RS00285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHX26_RS00290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CHX26_RS00320	COG1024	Enoyl-CoA hydratase
CHX26_RS00325	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS00355	COG2203	Gaf domain
CHX26_RS00355	COG4251	negative regulation of phosphorylation
CHX26_RS00355	COG3706	GGDEF domain
CHX26_RS00355	COG5001	Diguanylate cyclase
CHX26_RS00370	COG0469	pyruvate kinase activity
CHX26_RS00380	COG3750	Belongs to the UPF0335 family
CHX26_RS00385	COG0393	Putative heavy-metal-binding
CHX26_RS00395	COG0217	transcriptional regulatory protein
CHX26_RS00400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CHX26_RS00405	COG1393	Belongs to the ArsC family
CHX26_RS00410	COG3201	nicotinamide mononucleotide transporter
CHX26_RS00420	COG0584	glycerophosphoryl diester phosphodiesterase
CHX26_RS00425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CHX26_RS00430	COG0527	aspartate kinase activity
CHX26_RS00445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CHX26_RS00450	COG2070	2-Nitropropane dioxygenase
CHX26_RS00565	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS00665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CHX26_RS00700	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CHX26_RS00700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHX26_RS00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CHX26_RS00715	COG0085	RNA polymerase activity
CHX26_RS00725	COG3655	Transcriptional regulator
CHX26_RS00730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CHX26_RS00735	COG0222	ribosome binding
CHX26_RS00750	COG1462	curli production assembly transport component CsgG
CHX26_RS00795	COG0534	Mate efflux family protein
CHX26_RS00800	COG0668	transmembrane transport
CHX26_RS00805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CHX26_RS00810	COG0459	protein refolding
CHX26_RS00815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CHX26_RS00820	COG1494	fructose-1,6-bisphosphatase
CHX26_RS00865	COG1201	RNA secondary structure unwinding
CHX26_RS00885	COG1192	Involved in chromosome partitioning
CHX26_RS00890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CHX26_RS00905	COG2205	protein histidine kinase activity
CHX26_RS00905	COG0784	Response regulator, receiver
CHX26_RS00925	COG4206	TonB-dependent receptor
CHX26_RS00930	COG2755	lipolytic protein G-D-S-L family
CHX26_RS00930	COG0657	acetylesterase activity
CHX26_RS00935	COG1301	dicarboxylic acid transport
CHX26_RS00940	COG4191	Histidine kinase
CHX26_RS00945	COG2204	response regulator
CHX26_RS00960	COG2212	antiporter activity
CHX26_RS00970	COG0651	ATP synthesis coupled electron transport
CHX26_RS00975	COG1006	Multisubunit Na H antiporter MnhC subunit
CHX26_RS00980	COG2111	Na H antiporter
CHX26_RS00980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CHX26_RS00985	COG0175	sulfate reduction
CHX26_RS00995	COG1218	3'(2'),5'-bisphosphate nucleotidase
CHX26_RS01000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHX26_RS01020	COG1496	oxidoreductase activity
CHX26_RS01025	COG0308	aminopeptidase N
CHX26_RS01085	COG4206	TonB-dependent receptor
CHX26_RS01135	COG0515	serine threonine protein kinase
CHX26_RS01150	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CHX26_RS01190	COG2124	cytochrome p450
CHX26_RS01205	COG1053	succinate dehydrogenase
CHX26_RS01230	COG2130	NADP-dependent
CHX26_RS01240	COG2130	NADP-dependent
CHX26_RS01255	COG2124	cytochrome p450
CHX26_RS01265	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS01275	COG0183	Belongs to the thiolase family
CHX26_RS01290	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS01305	COG3483	tryptophan 2,3-dioxygenase activity
CHX26_RS01315	COG0747	negative chemotaxis
CHX26_RS01375	COG0156	8-amino-7-oxononanoate synthase activity
CHX26_RS01390	COG4695	Portal protein
CHX26_RS01465	COG2885	chlorophyll binding
CHX26_RS01465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CHX26_RS01475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CHX26_RS01490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHX26_RS01495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHX26_RS01500	COG1278	Cold shock
CHX26_RS01505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHX26_RS01505	COG3453	Protein conserved in bacteria
CHX26_RS01525	COG0004	ammonium transporteR
CHX26_RS01530	COG0347	Belongs to the P(II) protein family
CHX26_RS01535	COG2267	carboxylic ester hydrolase activity
CHX26_RS01540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CHX26_RS01545	COG4221	oxidoreductase activity
CHX26_RS01550	COG0072	phenylalanine-tRNA ligase activity
CHX26_RS01555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CHX26_RS01565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CHX26_RS01570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHX26_RS01575	COG1136	(ABC) transporter
CHX26_RS01575	COG0577	efflux transmembrane transporter activity
CHX26_RS01580	COG0577	efflux transmembrane transporter activity
CHX26_RS01580	COG1136	(ABC) transporter
CHX26_RS01585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHX26_RS01600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHX26_RS01615	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHX26_RS01625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CHX26_RS01630	COG0280	phosphate acetyltransferase
CHX26_RS01630	COG0281	malic enzyme
CHX26_RS01640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHX26_RS01650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CHX26_RS01655	COG1137	ATPase activity
CHX26_RS01665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CHX26_RS01670	COG0124	histidyl-tRNA synthetase
CHX26_RS01675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CHX26_RS01680	COG2890	protein-(glutamine-N5) methyltransferase activity
CHX26_RS01690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CHX26_RS01695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHX26_RS01715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHX26_RS01740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHX26_RS01745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHX26_RS01745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHX26_RS01770	COG3118	belongs to the thioredoxin family
CHX26_RS01780	COG4771	TonB-dependent receptor
CHX26_RS01785	COG3268	Saccharopine dehydrogenase
CHX26_RS01790	COG0717	Belongs to the dCTP deaminase family
CHX26_RS01815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CHX26_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS01835	COG4974	Belongs to the 'phage' integrase family
CHX26_RS01855	COG0789	Transcriptional regulator
CHX26_RS01935	COG0789	Transcriptional regulator
CHX26_RS01945	COG4644	lycopene metabolic process
CHX26_RS01995	COG0588	phosphoglycerate mutase activity
CHX26_RS02005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CHX26_RS02015	COG0196	riboflavin kinase activity
CHX26_RS02020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CHX26_RS02025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CHX26_RS02035	COG1253	flavin adenine dinucleotide binding
CHX26_RS02040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CHX26_RS02040	COG2885	chlorophyll binding
CHX26_RS02050	COG0045	succinate-CoA ligase (ADP-forming) activity
CHX26_RS02055	COG2086	electron transfer activity
CHX26_RS02075	COG2733	membrane
CHX26_RS02105	COG0482	sulfurtransferase activity
CHX26_RS02125	COG0259	pyridoxamine-phosphate oxidase activity
CHX26_RS02130	COG0484	heat shock protein binding
CHX26_RS02135	COG1295	ribonuclease BN
CHX26_RS02140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CHX26_RS02150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CHX26_RS02160	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CHX26_RS02170	COG0793	Belongs to the peptidase S41A family
CHX26_RS02180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CHX26_RS02185	COG0799	negative regulation of ribosome biogenesis
CHX26_RS02190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CHX26_RS02195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CHX26_RS02200	COG0739	heme binding
CHX26_RS02220	COG0438	transferase activity, transferring glycosyl groups
CHX26_RS02230	COG0625	glutathione transferase activity
CHX26_RS02260	COG1793	dna ligase
CHX26_RS02275	COG0113	porphobilinogen synthase activity
CHX26_RS02280	COG0739	heme binding
CHX26_RS02295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CHX26_RS02300	COG1329	Transcriptional regulator
CHX26_RS02315	COG0009	L-threonylcarbamoyladenylate synthase
CHX26_RS02320	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS02335	COG1956	GAF domain-containing protein
CHX26_RS02355	COG0357	Ribosomal RNA small subunit methyltransferase G
CHX26_RS02360	COG0445	tRNA wobble uridine modification
CHX26_RS02365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CHX26_RS02385	COG2200	EAL domain
CHX26_RS02390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CHX26_RS02395	COG1981	membrane
CHX26_RS02400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CHX26_RS02405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CHX26_RS02410	COG0424	maF-like protein
CHX26_RS02420	COG0237	dephospho-CoA kinase activity
CHX26_RS02425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHX26_RS02430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CHX26_RS02460	COG0316	Belongs to the HesB IscA family
CHX26_RS02465	COG0517	IMP dehydrogenase activity
CHX26_RS02500	COG0114	fumarate hydratase activity
CHX26_RS02505	COG3275	phosphorelay sensor kinase activity
CHX26_RS02535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CHX26_RS02540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHX26_RS02555	COG1612	heme a metabolic process
CHX26_RS02565	COG2022	thiamine diphosphate biosynthetic process
CHX26_RS02580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CHX26_RS02590	COG2268	Band 7 protein
CHX26_RS02610	COG0739	heme binding
CHX26_RS02615	COG2833	Protein of unknown function (DUF455)
CHX26_RS02620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CHX26_RS02625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CHX26_RS02645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CHX26_RS02655	COG1476	TRANSCRIPTIONal
CHX26_RS02660	COG2267	carboxylic ester hydrolase activity
CHX26_RS02680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHX26_RS02695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CHX26_RS02700	COG4152	abc transporter atp-binding protein
CHX26_RS02735	COG2188	Transcriptional regulator
CHX26_RS02740	COG3104	oligopeptide transport
CHX26_RS02745	COG1228	amidohydrolase
CHX26_RS02755	COG0545	Peptidyl-prolyl cis-trans isomerase
CHX26_RS02770	COG2853	Lipoprotein
CHX26_RS02780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CHX26_RS02790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHX26_RS02800	COG0138	bifunctional purine biosynthesis protein purh
CHX26_RS02830	COG0686	Belongs to the AlaDH PNT family
CHX26_RS02835	COG0590	tRNA wobble adenosine to inosine editing
CHX26_RS02840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHX26_RS02855	COG1570	exodeoxyribonuclease VII activity
CHX26_RS02860	COG0151	Belongs to the GarS family
CHX26_RS02865	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS02880	COG2267	carboxylic ester hydrolase activity
CHX26_RS02885	COG4771	TonB-dependent receptor
CHX26_RS02890	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHX26_RS02895	COG0022	dehydrogenase e1 component
CHX26_RS02905	COG1475	DNA binding
CHX26_RS03015	COG3436	PFAM IS66 Orf2 family protein
CHX26_RS03040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHX26_RS03065	COG0316	Belongs to the HesB IscA family
CHX26_RS03070	COG2151	metal-sulfur cluster biosynthetic enzyme
CHX26_RS03080	COG0719	Fe-S assembly protein
CHX26_RS03085	COG0396	ATPase activity
CHX26_RS03100	COG0719	Fe-S assembly protein
CHX26_RS03125	COG0167	dihydroorotate dehydrogenase activity
CHX26_RS03130	COG0405	Gamma-glutamyltransferase
CHX26_RS03135	COG1022	Amp-dependent synthetase and ligase
CHX26_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS03165	COG0495	leucyl-tRNA aminoacylation
CHX26_RS03195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHX26_RS03200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHX26_RS03210	COG1132	(ABC) transporter
CHX26_RS03215	COG3590	peptidase
CHX26_RS03220	COG1968	undecaprenyl-diphosphatase activity
CHX26_RS03230	COG3186	Phenylalanine-4-hydroxylase
CHX26_RS03235	COG2326	polyphosphate kinase activity
CHX26_RS03240	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CHX26_RS03245	COG0183	Belongs to the thiolase family
CHX26_RS03250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHX26_RS03285	COG1785	Belongs to the alkaline phosphatase family
CHX26_RS03295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHX26_RS03305	COG0564	pseudouridine synthase activity
CHX26_RS03315	COG0433	COG0433 Predicted ATPase
CHX26_RS03340	COG3706	GGDEF domain
CHX26_RS03360	COG4771	TonB-dependent receptor
CHX26_RS03365	COG1674	ftsk spoiiie
CHX26_RS03375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CHX26_RS03380	COG4771	TonB-dependent receptor
CHX26_RS03385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CHX26_RS03390	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS03395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CHX26_RS03415	COG1125	glycine betaine transport
CHX26_RS03415	COG0517	IMP dehydrogenase activity
CHX26_RS03420	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS03425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CHX26_RS03460	COG0628	permease
CHX26_RS03470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CHX26_RS03485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CHX26_RS03485	COG0519	Catalyzes the synthesis of GMP from XMP
CHX26_RS03520	COG1131	(ABC) transporter
CHX26_RS03535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHX26_RS03555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CHX26_RS03565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHX26_RS03565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHX26_RS03575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHX26_RS03575	COG1372	Participates in initiation and elongation during chromosome replication
CHX26_RS03600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CHX26_RS03610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CHX26_RS03620	COG2095	MarC family integral membrane protein
CHX26_RS03635	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CHX26_RS03635	COG0506	proline dehydrogenase activity
CHX26_RS03635	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CHX26_RS03650	COG4638	Rieske (2fe-2S)
CHX26_RS03665	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS03680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CHX26_RS03705	COG0385	Bile acid
CHX26_RS03710	COG4946	Tricorn protease homolog
CHX26_RS03710	COG0793	Belongs to the peptidase S41A family
CHX26_RS03755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CHX26_RS03760	COG1815	bacterial-type flagellum-dependent cell motility
CHX26_RS03775	COG4786	Flagellar basal body rod
CHX26_RS03780	COG4786	Flagellar basal body rod
CHX26_RS03785	COG4786	Flagellar basal body rod
CHX26_RS03790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CHX26_RS03795	COG1706	bacterial-type flagellum-dependent cell motility
CHX26_RS03810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CHX26_RS03820	COG1360	Flagellar Motor Protein
CHX26_RS03845	COG1677	Flagellar hook-basal body complex protein FliE
CHX26_RS03855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CHX26_RS03905	COG1987	bacterial-type flagellum assembly
CHX26_RS03915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CHX26_RS03935	COG2244	polysaccharide biosynthetic process
CHX26_RS03945	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CHX26_RS03965	COG3300	MHYT domain
CHX26_RS03965	COG5001	Diguanylate cyclase
CHX26_RS03980	COG2884	Cell division ATP-binding protein ftsE
CHX26_RS03995	COG0204	Acyl-transferase
CHX26_RS04000	COG0287	Prephenate dehydrogenase
CHX26_RS04005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHX26_RS04010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHX26_RS04015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHX26_RS04015	COG2813	Specifically methylates the guanine in position
CHX26_RS04040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHX26_RS04060	COG0489	protein tyrosine kinase activity
CHX26_RS04065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CHX26_RS04065	COG2010	Cytochrome c
CHX26_RS04070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CHX26_RS04085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHX26_RS04085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHX26_RS04090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHX26_RS04105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CHX26_RS04115	COG1002	Type II restriction enzyme, methylase subunits
CHX26_RS04120	COG1061	Type III restriction enzyme res subunit
CHX26_RS04125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CHX26_RS04145	COG3436	PFAM IS66 Orf2 family protein
CHX26_RS04160	COG4974	Belongs to the 'phage' integrase family
CHX26_RS04205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHX26_RS04220	COG0784	Response regulator, receiver
CHX26_RS04220	COG2205	protein histidine kinase activity
CHX26_RS04235	COG1482	cell wall glycoprotein biosynthetic process
CHX26_RS04240	COG4251	negative regulation of phosphorylation
CHX26_RS04275	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS04300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CHX26_RS04330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHX26_RS04335	COG0081	regulation of translation
CHX26_RS04355	COG1546	Belongs to the CinA family
CHX26_RS04355	COG1058	Belongs to the CinA family
CHX26_RS04375	COG1024	Enoyl-CoA hydratase
CHX26_RS04380	COG0183	Belongs to the thiolase family
CHX26_RS04395	COG0346	lactoylglutathione lyase activity
CHX26_RS04410	COG1032	radical SAM domain protein
CHX26_RS04470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CHX26_RS04475	COG3634	alkyl hydroperoxide reductase activity
CHX26_RS04480	COG0450	alkyl hydroperoxide reductase
CHX26_RS04490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CHX26_RS04495	COG0632	four-way junction helicase activity
CHX26_RS04505	COG2255	four-way junction helicase activity
CHX26_RS04525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHX26_RS04530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CHX26_RS04540	COG2989	Protein conserved in bacteria
CHX26_RS04560	COG0123	including yeast histone deacetylase and acetoin utilization protein
CHX26_RS04565	COG1971	Probably functions as a manganese efflux pump
CHX26_RS04575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CHX26_RS04595	COG2367	Beta-lactamase
CHX26_RS04615	COG0714	Associated with various cellular activities
CHX26_RS04630	COG0077	Prephenate dehydratase
CHX26_RS04630	COG1605	Chorismate mutase
CHX26_RS04635	COG3474	cytochrome
CHX26_RS04640	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CHX26_RS04645	COG0248	Ppx GppA phosphatase
CHX26_RS04680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CHX26_RS04700	COG1904	glucuronate isomerase
CHX26_RS04705	COG2271	Major facilitator Superfamily
CHX26_RS04710	COG0246	Mannitol dehydrogenase
CHX26_RS04715	COG2721	sulfolactate sulfo-lyase activity
CHX26_RS04725	COG3250	beta-galactosidase activity
CHX26_RS04760	COG3250	beta-galactosidase activity
CHX26_RS04770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHX26_RS04775	COG3250	beta-galactosidase activity
CHX26_RS04780	COG2211	Major facilitator Superfamily
CHX26_RS04785	COG4948	Mandelate Racemase Muconate Lactonizing
CHX26_RS04790	COG2186	Transcriptional regulator
CHX26_RS04820	COG0351	phosphomethylpyrimidine kinase
CHX26_RS04820	COG0352	thiamine-phosphate diphosphorylase activity
CHX26_RS04825	COG3608	succinylglutamate desuccinylase aspartoacylase
CHX26_RS04840	COG1131	(ABC) transporter
CHX26_RS04850	COG3813	Protein conserved in bacteria
CHX26_RS04855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHX26_RS04880	COG3920	Histidine kinase
CHX26_RS04885	COG0784	Response regulator, receiver
CHX26_RS04905	COG0795	lipopolysaccharide-transporting ATPase activity
CHX26_RS04925	COG3243	poly(R)-hydroxyalkanoic acid synthase
CHX26_RS04930	COG0436	Aminotransferase
CHX26_RS04960	COG1024	Enoyl-CoA hydratase
CHX26_RS04980	COG1012	belongs to the aldehyde dehydrogenase family
CHX26_RS04995	COG2205	protein histidine kinase activity
CHX26_RS04995	COG2202	Pas domain
CHX26_RS05025	COG4772	TonB-dependent receptor
CHX26_RS05030	COG3474	cytochrome
CHX26_RS05090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHX26_RS05100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CHX26_RS05120	COG0646	methionine synthase
CHX26_RS05120	COG1410	methionine synthase
CHX26_RS05135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CHX26_RS05140	COG0509	glycine decarboxylation via glycine cleavage system
CHX26_RS05145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHX26_RS05150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHX26_RS05165	COG3386	PFAM SMP-30 Gluconolaconase
CHX26_RS05180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHX26_RS05185	COG1414	Transcriptional regulator
CHX26_RS05190	COG4774	siderophore transport
CHX26_RS05195	COG0655	NAD(P)H dehydrogenase (quinone) activity
CHX26_RS05205	COG2267	carboxylic ester hydrolase activity
CHX26_RS05235	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05240	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05245	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05255	COG0183	Belongs to the thiolase family
CHX26_RS05260	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05265	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05270	COG1024	Enoyl-CoA hydratase
CHX26_RS05280	COG1024	Enoyl-CoA hydratase
CHX26_RS05300	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05305	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05325	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CHX26_RS05330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHX26_RS05335	COG1053	succinate dehydrogenase
CHX26_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05355	COG4771	TonB-dependent receptor
CHX26_RS05380	COG1053	succinate dehydrogenase
CHX26_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05390	COG0300	oxidoreductase activity
CHX26_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05405	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05440	COG1522	sequence-specific DNA binding
CHX26_RS05450	COG4638	Rieske (2fe-2S)
CHX26_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS05460	COG1902	pentaerythritol trinitrate reductase activity
CHX26_RS05465	COG1902	pentaerythritol trinitrate reductase activity
CHX26_RS05465	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHX26_RS05485	COG0745	RESPONSE REGULATOR receiver
CHX26_RS05490	COG0784	Response regulator, receiver
CHX26_RS05490	COG4191	Histidine kinase
CHX26_RS05495	COG2366	antibiotic biosynthetic process
CHX26_RS05505	COG1064	alcohol dehydrogenase
CHX26_RS05540	COG0363	glucosamine-6-phosphate deaminase activity
CHX26_RS05545	COG0494	nUDIX hydrolase
CHX26_RS05555	COG2814	Major facilitator Superfamily
CHX26_RS05560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CHX26_RS05615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CHX26_RS05635	COG1278	Cold shock
CHX26_RS05700	COG2171	N-acyltransferase activity
CHX26_RS05715	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05720	COG2211	Major facilitator Superfamily
CHX26_RS05725	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05730	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS05745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHX26_RS05750	COG0194	GDP metabolic process
CHX26_RS05765	COG0131	Imidazoleglycerol-phosphate dehydratase
CHX26_RS05775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CHX26_RS05780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CHX26_RS05790	COG0107	imidazoleglycerol-phosphate synthase activity
CHX26_RS05795	COG0140	phosphoribosyl-ATP diphosphatase activity
CHX26_RS05805	COG0824	Thioesterase
CHX26_RS05815	COG0848	biopolymer transport protein
CHX26_RS05825	COG0823	Involved in the tonB-independent uptake of proteins
CHX26_RS05830	COG2885	chlorophyll binding
CHX26_RS05835	COG0484	heat shock protein binding
CHX26_RS05845	COG1228	amidohydrolase
CHX26_RS05860	COG0471	metal ion transport
CHX26_RS05865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CHX26_RS05875	COG0408	coproporphyrinogen oxidase activity
CHX26_RS05905	COG4106	trans-aconitate 2-methyltransferase activity
CHX26_RS05935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHX26_RS05945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CHX26_RS05960	COG1335	isochorismatase
CHX26_RS05985	COG0604	alcohol dehydrogenase
CHX26_RS06015	COG4774	siderophore transport
CHX26_RS06025	COG4772	TonB-dependent receptor
CHX26_RS06050	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS06085	COG0154	amidase activity
CHX26_RS06130	COG1522	sequence-specific DNA binding
CHX26_RS06180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CHX26_RS06205	COG3279	Response regulator of the LytR AlgR family
CHX26_RS06210	COG3275	phosphorelay sensor kinase activity
CHX26_RS06220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CHX26_RS06220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHX26_RS06225	COG0501	Belongs to the peptidase M48B family
CHX26_RS06280	COG1192	Involved in chromosome partitioning
CHX26_RS06335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CHX26_RS06360	COG4974	Belongs to the 'phage' integrase family
CHX26_RS06365	COG0582	viral genome integration into host DNA
CHX26_RS06370	COG3077	Addiction module antitoxin, RelB DinJ family
CHX26_RS06395	COG0746	molybdenum cofactor guanylyltransferase activity
CHX26_RS06400	COG3119	arylsulfatase activity
CHX26_RS06405	COG0596	Alpha beta hydrolase
CHX26_RS06415	COG0033	Phosphoglucomutase
CHX26_RS06420	COG0297	glycogen (starch) synthase activity
CHX26_RS06425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CHX26_RS06430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CHX26_RS06435	COG0058	SHG alpha-glucan phosphorylase activity
CHX26_RS06465	COG0431	NADPH-dependent FMN reductase
CHX26_RS06475	COG2855	membrane
CHX26_RS06485	COG4771	TonB-dependent receptor
CHX26_RS06490	COG1501	Belongs to the glycosyl hydrolase 31 family
CHX26_RS06500	COG0667	Aldo Keto reductase
CHX26_RS06505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHX26_RS06510	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS06515	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS06520	COG0513	Belongs to the DEAD box helicase family
CHX26_RS06530	COG1609	Transcriptional regulator
CHX26_RS06540	COG4771	TonB-dependent receptor
CHX26_RS06545	COG1621	beta-fructofuranosidase activity
CHX26_RS06550	COG1940	carbohydrate kinase activity
CHX26_RS06560	COG0800	Aldolase
CHX26_RS06565	COG0129	dihydroxy-acid dehydratase activity
CHX26_RS06570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CHX26_RS06580	COG1609	Transcriptional regulator
CHX26_RS06590	COG0837	glucose binding
CHX26_RS06615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHX26_RS06670	COG3047	cAMP biosynthetic process
CHX26_RS06675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHX26_RS06710	COG0183	Belongs to the thiolase family
CHX26_RS06730	COG1024	Enoyl-CoA hydratase
CHX26_RS06785	COG3422	double-strand break repair
CHX26_RS06790	COG0328	RNA-DNA hybrid ribonuclease activity
CHX26_RS06795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CHX26_RS06800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CHX26_RS06810	COG0018	arginyl-trna synthetase
CHX26_RS06820	COG1472	Belongs to the glycosyl hydrolase 3 family
CHX26_RS06825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CHX26_RS06830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CHX26_RS06835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHX26_RS06840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHX26_RS06845	COG0805	protein transport
CHX26_RS06855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CHX26_RS06860	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CHX26_RS06880	COG1476	TRANSCRIPTIONal
CHX26_RS06910	COG0174	glutamine synthetase
CHX26_RS06915	COG0347	Belongs to the P(II) protein family
CHX26_RS06920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CHX26_RS06940	COG0024	Methionine aminopeptidase
CHX26_RS06950	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHX26_RS06955	COG4133	protoheme IX ABC transporter activity
CHX26_RS06960	COG2154	pterin-4-alpha-carbinolamine dehydratase
CHX26_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS06985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CHX26_RS07000	COG2001	Belongs to the MraZ family
CHX26_RS07005	COG0275	rRNA processing
CHX26_RS07020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CHX26_RS07025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHX26_RS07030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHX26_RS07035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CHX26_RS07045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHX26_RS07050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHX26_RS07055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHX26_RS07060	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHX26_RS07065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CHX26_RS07070	COG0849	cell division
CHX26_RS07090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHX26_RS07095	COG0670	Belongs to the BI1 family
CHX26_RS07125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CHX26_RS07140	COG0175	sulfate reduction
CHX26_RS07165	COG1648	precorrin-2 dehydrogenase activity
CHX26_RS07165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CHX26_RS07175	COG0626	cystathionine gamma-synthase activity
CHX26_RS07180	COG2897	thiosulfate sulfurtransferase activity
CHX26_RS07190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CHX26_RS07195	COG3300	MHYT domain
CHX26_RS07195	COG5001	Diguanylate cyclase
CHX26_RS07200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHX26_RS07215	COG0668	transmembrane transport
CHX26_RS07230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CHX26_RS07235	COG1695	Transcriptional regulator
CHX26_RS07245	COG0438	transferase activity, transferring glycosyl groups
CHX26_RS07255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHX26_RS07260	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CHX26_RS07265	COG0251	oxidation-reduction process
CHX26_RS07275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CHX26_RS07290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CHX26_RS07290	COG1648	precorrin-2 dehydrogenase activity
CHX26_RS07295	COG0019	diaminopimelate decarboxylase activity
CHX26_RS07305	COG0165	Argininosuccinate lyase
CHX26_RS07310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHX26_RS07325	COG0252	asparaginase activity
CHX26_RS07345	COG0101	tRNA pseudouridine synthase activity
CHX26_RS07350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CHX26_RS07355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CHX26_RS07360	COG0242	peptide deformylase activity
CHX26_RS07365	COG1322	Protein conserved in bacteria
CHX26_RS07370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHX26_RS07385	COG1660	Displays ATPase and GTPase activities
CHX26_RS07390	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CHX26_RS07395	COG2205	protein histidine kinase activity
CHX26_RS07400	COG0745	RESPONSE REGULATOR receiver
CHX26_RS07405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CHX26_RS07430	COG2945	thiolester hydrolase activity
CHX26_RS07435	COG1104	cysteine desulfurase activity
CHX26_RS07440	COG1104	cysteine desulfurase activity
CHX26_RS07450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHX26_RS07460	COG0617	tRNA 3'-terminal CCA addition
CHX26_RS07465	COG0494	nUDIX hydrolase
CHX26_RS07480	COG2133	pyrroloquinoline quinone binding
CHX26_RS07485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHX26_RS07500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CHX26_RS07565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CHX26_RS07610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHX26_RS07620	COG0047	phosphoribosylformylglycinamidine synthase activity
CHX26_RS07625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHX26_RS07635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CHX26_RS07645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CHX26_RS07655	COG0424	maF-like protein
CHX26_RS07660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHX26_RS07670	COG2081	HI0933 family
CHX26_RS07675	COG0322	excinuclease ABC activity
CHX26_RS07685	COG2885	chlorophyll binding
CHX26_RS07690	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CHX26_RS07720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CHX26_RS07725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CHX26_RS07730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHX26_RS07735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CHX26_RS07740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CHX26_RS07750	COG0596	Alpha beta hydrolase
CHX26_RS07755	COG0300	oxidoreductase activity
CHX26_RS07760	COG1051	belongs to the nudix hydrolase family
CHX26_RS07800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CHX26_RS07825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CHX26_RS07835	COG0681	Belongs to the peptidase S26 family
CHX26_RS07840	COG0736	holo-[acyl-carrier-protein] synthase activity
CHX26_RS07850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CHX26_RS07855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHX26_RS07860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CHX26_RS07865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CHX26_RS07870	COG0109	protoheme IX farnesyltransferase activity
CHX26_RS07915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CHX26_RS07925	COG0314	molybdopterin synthase activity
CHX26_RS07945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CHX26_RS07950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CHX26_RS07965	COG0354	folic acid binding
CHX26_RS07970	COG0418	dihydroorotase activity
CHX26_RS08000	COG1012	belongs to the aldehyde dehydrogenase family
CHX26_RS08050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CHX26_RS08060	COG1131	(ABC) transporter
CHX26_RS08075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHX26_RS08075	COG1199	ATP-dependent helicase activity
CHX26_RS08080	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CHX26_RS08145	COG1522	sequence-specific DNA binding
CHX26_RS08155	COG1252	NADH dehydrogenase
CHX26_RS08160	COG0439	Biotin carboxylase
CHX26_RS08165	COG0511	ligase activity, forming carbon-carbon bonds
CHX26_RS08170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CHX26_RS08185	COG2301	Belongs to the HpcH HpaI aldolase family
CHX26_RS08210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CHX26_RS08225	COG3328	transposase activity
CHX26_RS08235	COG2211	Major facilitator Superfamily
CHX26_RS08245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CHX26_RS08255	COG1862	Preprotein translocase
CHX26_RS08260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHX26_RS08265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHX26_RS08290	COG0488	(ABC) transporter
CHX26_RS08320	COG0287	Prephenate dehydrogenase
CHX26_RS08320	COG1605	Chorismate mutase
CHX26_RS08325	COG0142	geranyltranstransferase activity
CHX26_RS08330	COG1643	Atp-dependent helicase
CHX26_RS08345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHX26_RS08350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CHX26_RS08360	COG0776	regulation of translation
CHX26_RS08370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHX26_RS08380	COG0582	viral genome integration into host DNA
CHX26_RS08445	COG3002	Belongs to the UPF0753 family
CHX26_RS08465	COG0688	phosphatidylethanolamine metabolic process
CHX26_RS08475	COG0052	Belongs to the universal ribosomal protein uS2 family
CHX26_RS08480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CHX26_RS08485	COG0528	UMP kinase activity
CHX26_RS08490	COG0233	cytoplasmic translational termination
CHX26_RS08495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CHX26_RS08505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CHX26_RS08510	COG0750	zinc metalloprotease
CHX26_RS08515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CHX26_RS08525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHX26_RS08530	COG0254	rRNA binding
CHX26_RS08555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHX26_RS08560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CHX26_RS08565	COG1138	Cytochrome C-type biogenesis protein
CHX26_RS08570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHX26_RS08575	COG3088	subunit of a heme lyase
CHX26_RS08585	COG3158	transport of potassium into the cell
CHX26_RS08590	COG2917	probably involved in intracellular septation
CHX26_RS08595	COG0552	protein localization to endoplasmic reticulum
CHX26_RS08600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHX26_RS08605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CHX26_RS08610	COG5001	Diguanylate cyclase
CHX26_RS08610	COG3300	MHYT domain
CHX26_RS08620	COG0028	Belongs to the TPP enzyme family
CHX26_RS08635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHX26_RS08650	COG0583	DNA-binding transcription factor activity
CHX26_RS08655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CHX26_RS08660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHX26_RS08665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHX26_RS08670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHX26_RS08675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CHX26_RS08690	COG0582	viral genome integration into host DNA
CHX26_RS08695	COG3328	transposase activity
CHX26_RS08700	COG0741	lytic transglycosylase activity
CHX26_RS08700	COG1196	nuclear chromosome segregation
CHX26_RS08700	COG0739	heme binding
CHX26_RS08715	COG5642	Protein of unknown function (DUF2384)
CHX26_RS08735	COG1231	oxidoreductase activity
CHX26_RS08755	COG3300	MHYT domain
CHX26_RS08755	COG5001	Diguanylate cyclase
CHX26_RS08805	COG1475	DNA binding
CHX26_RS08810	COG4227	nucleotidyltransferase activity
CHX26_RS08825	COG3311	Transcriptional regulator
CHX26_RS08845	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CHX26_RS08900	COG3676	manually curated
CHX26_RS08905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CHX26_RS08910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CHX26_RS08960	COG5001	Diguanylate cyclase
CHX26_RS08960	COG3300	MHYT domain
CHX26_RS08985	COG1091	dTDP-4-dehydrorhamnose reductase activity
CHX26_RS08995	COG4566	intracellular signal transduction
CHX26_RS09015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHX26_RS09030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHX26_RS09060	COG1086	Polysaccharide biosynthesis protein
CHX26_RS09080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHX26_RS09100	COG3436	PFAM IS66 Orf2 family protein
CHX26_RS09125	COG3436	PFAM IS66 Orf2 family protein
CHX26_RS09145	COG3328	transposase activity
CHX26_RS09325	COG3706	GGDEF domain
CHX26_RS09330	COG4152	abc transporter atp-binding protein
CHX26_RS09365	COG0612	Peptidase, M16
CHX26_RS09390	COG3328	transposase activity
CHX26_RS09410	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CHX26_RS09430	COG2271	Major facilitator Superfamily
CHX26_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS09460	COG0501	Belongs to the peptidase M48B family
CHX26_RS09535	COG0515	serine threonine protein kinase
CHX26_RS09540	COG0840	transmembrane signaling receptor activity
CHX26_RS09575	COG2205	protein histidine kinase activity
CHX26_RS09595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHX26_RS09600	COG1506	peptidase
CHX26_RS09600	COG0823	Involved in the tonB-independent uptake of proteins
CHX26_RS09615	COG3328	transposase activity
CHX26_RS09640	COG1309	transcriptional regulator
CHX26_RS09710	COG2226	methyltransferase
CHX26_RS09725	COG1396	sequence-specific DNA binding
CHX26_RS09725	COG3800	Transcriptional regulator
CHX26_RS09730	COG0500	methyltransferase
CHX26_RS09745	COG1748	Saccharopine dehydrogenase
CHX26_RS09765	COG1704	LemA family
CHX26_RS09775	COG0183	Belongs to the thiolase family
CHX26_RS09795	COG0438	transferase activity, transferring glycosyl groups
CHX26_RS09805	COG0070	glutamate synthase
CHX26_RS09805	COG0067	glutamate synthase
CHX26_RS09805	COG0069	glutamate synthase activity
CHX26_RS09815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHX26_RS09835	COG0156	8-amino-7-oxononanoate synthase activity
CHX26_RS09840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CHX26_RS09845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CHX26_RS09850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CHX26_RS09850	COG0758	DNA mediated transformation
CHX26_RS09855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHX26_RS09855	COG1754	DNA topoisomerase type I activity
CHX26_RS09865	COG0745	RESPONSE REGULATOR receiver
CHX26_RS09875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CHX26_RS09880	COG0571	ribonuclease III activity
CHX26_RS09885	COG0681	Belongs to the peptidase S26 family
CHX26_RS09890	COG0166	Belongs to the GPI family
CHX26_RS09915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CHX26_RS09925	COG0346	lactoylglutathione lyase activity
CHX26_RS09930	COG1024	Enoyl-CoA hydratase
CHX26_RS09945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CHX26_RS09955	COG4770	biotin carboxylase activity
CHX26_RS09960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CHX26_RS09965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CHX26_RS09980	COG4974	Belongs to the 'phage' integrase family
CHX26_RS09985	COG0825	malonyl-CoA metabolic process
CHX26_RS10020	COG0302	gtp cyclohydrolase
CHX26_RS10035	COG0678	peroxiredoxin activity
CHX26_RS10035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHX26_RS10040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CHX26_RS10045	COG2205	protein histidine kinase activity
CHX26_RS10050	COG0802	atpase or kinase
CHX26_RS10055	COG3178	'Phosphotransferase
CHX26_RS10060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CHX26_RS10080	COG0483	inositol monophosphate 1-phosphatase activity
CHX26_RS10085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CHX26_RS10095	COG0653	protein targeting
CHX26_RS10110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CHX26_RS10125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHX26_RS10135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CHX26_RS10140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CHX26_RS10145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CHX26_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS10170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CHX26_RS10200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHX26_RS10225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CHX26_RS10230	COG0126	phosphoglycerate kinase activity
CHX26_RS10245	COG3588	fructose-bisphosphate aldolase
CHX26_RS10250	COG0352	thiamine-phosphate diphosphorylase activity
CHX26_RS10265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHX26_RS10270	COG0483	inositol monophosphate 1-phosphatase activity
CHX26_RS10300	COG1396	sequence-specific DNA binding
CHX26_RS10300	COG3800	Transcriptional regulator
CHX26_RS10305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHX26_RS10310	COG4191	Histidine kinase
CHX26_RS10315	COG2204	response regulator
CHX26_RS10330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CHX26_RS10335	COG0531	amino acid
CHX26_RS10370	COG0745	RESPONSE REGULATOR receiver
CHX26_RS10375	COG0704	Plays a role in the regulation of phosphate uptake
CHX26_RS10380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHX26_RS10390	COG0573	inorganic phosphate transmembrane transporter activity
CHX26_RS10395	COG5002	protein histidine kinase activity
CHX26_RS10405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHX26_RS10445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHX26_RS10460	COG2353	YceI-like domain
CHX26_RS10465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CHX26_RS10475	COG0028	Belongs to the TPP enzyme family
CHX26_RS10480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CHX26_RS10485	COG3830	Belongs to the UPF0237 family
CHX26_RS10485	COG0560	Phosphoserine phosphatase
CHX26_RS10505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHX26_RS10520	COG1722	exodeoxyribonuclease VII activity
CHX26_RS10525	COG0142	geranyltranstransferase activity
CHX26_RS10530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CHX26_RS10540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CHX26_RS10545	COG1131	(ABC) transporter
CHX26_RS10550	COG0842	Transport permease protein
CHX26_RS10560	COG0343	queuine tRNA-ribosyltransferase activity
CHX26_RS10575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CHX26_RS10585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHX26_RS10595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CHX26_RS10600	COG0698	ribose 5-phosphate isomerase
CHX26_RS10605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHX26_RS10610	COG0358	DNA primase activity
CHX26_RS10625	COG0505	Belongs to the CarA family
CHX26_RS10635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHX26_RS10670	COG0148	phosphopyruvate hydratase activity
CHX26_RS10680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CHX26_RS10700	COG0768	penicillin binding
CHX26_RS10720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHX26_RS10730	COG0012	GTP binding
CHX26_RS10735	COG0300	oxidoreductase activity
CHX26_RS10745	COG0193	aminoacyl-tRNA hydrolase activity
CHX26_RS10750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CHX26_RS10785	COG0752	glycyl-tRNA synthetase alpha subunit
CHX26_RS10790	COG0751	glycine-tRNA ligase activity
CHX26_RS10795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHX26_RS10795	COG0574	Belongs to the PEP-utilizing enzyme family
CHX26_RS10805	COG1040	competence protein
CHX26_RS10810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CHX26_RS10815	COG0789	Transcriptional regulator
CHX26_RS10845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CHX26_RS10855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CHX26_RS10860	COG3876	Protein conserved in bacteria
CHX26_RS10865	COG2814	Major facilitator Superfamily
CHX26_RS10885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHX26_RS10895	COG0187	DNA topoisomerase II activity
CHX26_RS10905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CHX26_RS10910	COG0792	nuclease activity
CHX26_RS10915	COG0189	ligase activity
CHX26_RS10920	COG0586	Pfam SNARE associated Golgi protein
CHX26_RS10925	COG4974	Belongs to the 'phage' integrase family
CHX26_RS10930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHX26_RS10940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHX26_RS10945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CHX26_RS10950	COG1420	regulation of RNA biosynthetic process
CHX26_RS10955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CHX26_RS10970	COG0443	Heat shock 70 kDa protein
CHX26_RS10975	COG0484	heat shock protein binding
CHX26_RS10985	COG1752	Esterase of the alpha-beta hydrolase superfamily
CHX26_RS11005	COG0477	Major facilitator Superfamily
CHX26_RS11010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CHX26_RS11015	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CHX26_RS11020	COG0442	prolyl-tRNA aminoacylation
CHX26_RS11025	COG2234	aminopeptidase activity
CHX26_RS11030	COG0557	exoribonuclease II activity
CHX26_RS11040	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHX26_RS11050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHX26_RS11055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHX26_RS11065	COG2951	lytic endotransglycosylase activity
CHX26_RS11075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CHX26_RS11090	COG0084	hydrolase, TatD family'
CHX26_RS11095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHX26_RS11095	COG0321	lipoyl(octanoyl) transferase activity
CHX26_RS11105	COG3956	TIGRFAM MazG family protein
CHX26_RS11110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHX26_RS11115	COG1923	regulation of RNA biosynthetic process
CHX26_RS11125	COG5000	phosphorelay sensor kinase activity
CHX26_RS11130	COG2204	response regulator
CHX26_RS11135	COG3852	Histidine kinase
CHX26_RS11145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CHX26_RS11145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CHX26_RS11155	COG1058	Belongs to the CinA family
CHX26_RS11155	COG1546	Belongs to the CinA family
CHX26_RS11160	COG2867	negative regulation of translational initiation
CHX26_RS11165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CHX26_RS11175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHX26_RS11185	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CHX26_RS11215	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHX26_RS11215	COG0022	dehydrogenase e1 component
CHX26_RS11220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CHX26_RS11235	COG2814	Major facilitator Superfamily
CHX26_RS11250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHX26_RS11260	COG0071	Belongs to the small heat shock protein (HSP20) family
CHX26_RS11265	COG0504	CTP synthase activity
CHX26_RS11275	COG0149	triose-phosphate isomerase activity
CHX26_RS11285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CHX26_RS11290	COG3698	Phosphodiester glycosidase
CHX26_RS11300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CHX26_RS11305	COG0134	indole-3-glycerol-phosphate synthase activity
CHX26_RS11310	COG0315	cyclic pyranopterin monophosphate synthase activity
CHX26_RS11315	COG0303	'Molybdopterin
CHX26_RS11320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CHX26_RS11325	COG0658	competence protein
CHX26_RS11325	COG2333	competence protein COMEC
CHX26_RS11330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHX26_RS11335	COG0372	Belongs to the citrate synthase family
CHX26_RS11345	COG0784	Response regulator, receiver
CHX26_RS11345	COG2198	Histidine kinase
CHX26_RS11345	COG5002	protein histidine kinase activity
CHX26_RS11380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CHX26_RS11390	COG1007	ATP synthesis coupled electron transport
CHX26_RS11405	COG0713	ATP synthesis coupled electron transport
CHX26_RS11415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHX26_RS11425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CHX26_RS11435	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CHX26_RS11440	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CHX26_RS11450	COG0649	NAD binding
CHX26_RS11455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHX26_RS11460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHX26_RS11465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHX26_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
CHX26_RS11475	COG0183	Belongs to the thiolase family
CHX26_RS11505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CHX26_RS11510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CHX26_RS11515	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHX26_RS11525	COG2226	methyltransferase
CHX26_RS11540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CHX26_RS11555	COG0367	asparagine synthase
CHX26_RS11580	COG3267	Type II secretory pathway component ExeA
CHX26_RS11580	COG3409	Peptidoglycan-binding domain 1 protein
CHX26_RS11590	COG0489	protein tyrosine kinase activity
CHX26_RS11600	COG1596	polysaccharide export
CHX26_RS11635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHX26_RS11640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CHX26_RS11640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CHX26_RS11650	COG0129	dihydroxy-acid dehydratase activity
CHX26_RS11660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CHX26_RS11680	COG0521	Mo-molybdopterin cofactor biosynthetic process
CHX26_RS11695	COG0318	PFAM AMP-dependent synthetase and ligase
CHX26_RS11705	COG0386	Belongs to the glutathione peroxidase family
CHX26_RS11710	COG1136	(ABC) transporter
CHX26_RS11715	COG4591	ABC-type transport system involved in lipoprotein release permease component
CHX26_RS11720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CHX26_RS11725	COG4221	oxidoreductase activity
CHX26_RS11740	COG0415	Belongs to the DNA photolyase family
CHX26_RS11750	COG0657	acetylesterase activity
CHX26_RS11755	COG1051	belongs to the nudix hydrolase family
CHX26_RS11765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHX26_RS11765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHX26_RS11780	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS11800	COG3682	Transcriptional regulator
CHX26_RS11825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CHX26_RS11845	COG2264	protein methyltransferase activity
CHX26_RS11850	COG1546	Belongs to the CinA family
CHX26_RS11850	COG1058	Belongs to the CinA family
CHX26_RS11855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CHX26_RS11870	COG0497	DNA recombination
CHX26_RS11890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CHX26_RS11910	COG0481	GTPase activity
CHX26_RS11915	COG5001	Diguanylate cyclase
CHX26_RS11915	COG3300	MHYT domain
CHX26_RS11920	COG3300	MHYT domain
CHX26_RS11920	COG5001	Diguanylate cyclase
CHX26_RS11960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CHX26_RS11965	COG1619	proteins homologs of microcin C7 resistance protein MccF
CHX26_RS11995	COG2354	Protein conserved in bacteria
CHX26_RS12000	COG0360	Binds together with S18 to 16S ribosomal RNA
CHX26_RS12005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CHX26_RS12010	COG0359	binds to the 23S rRNA
CHX26_RS12015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CHX26_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS12025	COG0189	ligase activity
CHX26_RS12030	COG4067	protein conserved in archaea
CHX26_RS12030	COG0189	ligase activity
CHX26_RS12060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHX26_RS12070	COG0335	large ribosomal subunit rRNA binding
CHX26_RS12075	COG0336	Belongs to the RNA methyltransferase TrmD family
CHX26_RS12095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CHX26_RS12100	COG0228	four-way junction DNA binding
CHX26_RS12105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHX26_RS12120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHX26_RS12135	COG0539	negative regulation of cytoplasmic translation
CHX26_RS12140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHX26_RS12155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CHX26_RS12160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CHX26_RS12165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHX26_RS12170	COG0356	it plays a direct role in the translocation of protons across the membrane
CHX26_RS12195	COG2003	Belongs to the UPF0758 family
CHX26_RS12200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CHX26_RS12210	COG0284	orotidine-5'-phosphate decarboxylase activity
CHX26_RS12225	COG0135	phosphoribosylanthranilate isomerase activity
CHX26_RS12230	COG0133	tryptophan synthase activity
CHX26_RS12235	COG0159	tryptophan synthase activity
CHX26_RS12240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CHX26_RS12245	COG0285	dihydrofolate synthase activity
CHX26_RS12250	COG2223	nitrite transmembrane transporter activity
CHX26_RS12260	COG1187	pseudouridine synthase activity
CHX26_RS12265	COG0742	ribosomal rna small subunit methyltransferase
CHX26_RS12270	COG0210	DNA helicase
CHX26_RS12285	COG0277	FAD linked oxidase domain protein
CHX26_RS12310	COG0538	isocitrate dehydrogenase activity
CHX26_RS12325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CHX26_RS12330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CHX26_RS12355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CHX26_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHX26_RS12365	COG0741	lytic transglycosylase activity
CHX26_RS12380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CHX26_RS12390	COG2226	methyltransferase
CHX26_RS12395	COG2258	MOSC domain
CHX26_RS12415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CHX26_RS12420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CHX26_RS12430	COG0137	argininosuccinate synthase activity
CHX26_RS12435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CHX26_RS12440	COG4145	pantothenate transmembrane transporter activity
CHX26_RS12455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHX26_RS12470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CHX26_RS12475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHX26_RS12495	COG0039	L-malate dehydrogenase activity
CHX26_RS12505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CHX26_RS12515	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHX26_RS12520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHX26_RS12530	COG2860	membrane
CHX26_RS12550	COG0203	ribosomal protein L17
CHX26_RS12555	COG0202	RNA polymerase activity
CHX26_RS12560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CHX26_RS12565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHX26_RS12575	COG0563	adenylate kinase activity
CHX26_RS12580	COG0201	protein transport
CHX26_RS12585	COG0200	Binds to the 23S rRNA
CHX26_RS12590	COG1841	ribosomal large subunit assembly
CHX26_RS12595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHX26_RS12600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHX26_RS12605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHX26_RS12610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CHX26_RS12615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CHX26_RS12620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHX26_RS12625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHX26_RS12630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CHX26_RS12635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CHX26_RS12640	COG0255	Belongs to the universal ribosomal protein uL29 family
CHX26_RS12645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CHX26_RS12650	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHX26_RS12655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CHX26_RS12660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHX26_RS12665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHX26_RS12670	COG0089	rRNA binding
CHX26_RS12675	COG0088	Forms part of the polypeptide exit tunnel
CHX26_RS12680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CHX26_RS12685	COG0051	transcription antitermination factor activity, RNA binding
CHX26_RS12690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHX26_RS12695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHX26_RS12700	COG0049	tRNA binding
CHX26_RS12705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CHX26_RS12720	COG2967	ApaG domain
CHX26_RS12725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CHX26_RS12765	COG0473	3-isopropylmalate dehydrogenase activity
CHX26_RS12770	COG1381	Involved in DNA repair and RecF pathway recombination
CHX26_RS12790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CHX26_RS12800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHX26_RS12810	COG1054	Belongs to the UPF0176 family
CHX26_RS12825	COG1741	Belongs to the pirin family
CHX26_RS12830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CHX26_RS12845	COG0625	glutathione transferase activity
CHX26_RS12875	COG0688	phosphatidylethanolamine metabolic process
CHX26_RS12890	COG0492	ferredoxin-NADP+ reductase activity
CHX26_RS12910	COG4206	TonB-dependent receptor
CHX26_RS12920	COG0640	Transcriptional regulator
CHX26_RS12930	COG0659	secondary active sulfate transmembrane transporter activity
CHX26_RS12945	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CHX26_RS12960	COG1472	Belongs to the glycosyl hydrolase 3 family
CHX26_RS13015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CHX26_RS13020	COG0612	Peptidase, M16
CHX26_RS13025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CHX26_RS13045	COG4957	zinc ion binding
CHX26_RS13060	COG0583	DNA-binding transcription factor activity
CHX26_RS13065	COG1253	flavin adenine dinucleotide binding
CHX26_RS13080	COG1702	phosphate starvation-inducible protein PhoH
CHX26_RS13085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHX26_RS13095	COG2239	Acts as a magnesium transporter
CHX26_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS13125	COG3842	ATPase activity
CHX26_RS13130	COG0864	Transcriptional regulator
CHX26_RS13155	COG0784	Response regulator, receiver
CHX26_RS13155	COG2198	Histidine kinase
CHX26_RS13155	COG5002	protein histidine kinase activity
CHX26_RS13160	COG3437	response regulator, receiver
CHX26_RS13175	COG4206	TonB-dependent receptor
CHX26_RS13180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHX26_RS13185	COG2816	NAD+ diphosphatase activity
CHX26_RS13230	COG0776	regulation of translation
CHX26_RS13235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHX26_RS13240	COG0416	fatty acid biosynthetic process
CHX26_RS13245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CHX26_RS13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHX26_RS13290	COG1012	belongs to the aldehyde dehydrogenase family
CHX26_RS13300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHX26_RS13305	COG0215	cysteine-tRNA ligase activity
CHX26_RS13330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CHX26_RS13355	COG3046	protein related to deoxyribodipyrimidine photolyase
CHX26_RS13390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHX26_RS13395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CHX26_RS13400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CHX26_RS13405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CHX26_RS13410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CHX26_RS13415	COG1505	serine-type exopeptidase activity
CHX26_RS13435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CHX26_RS13440	COG0546	phosphoglycolate phosphatase activity
CHX26_RS13445	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS13460	COG1045	serine acetyltransferase
CHX26_RS13475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CHX26_RS13480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CHX26_RS13490	COG0105	UTP biosynthetic process
CHX26_RS13510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHX26_RS13515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CHX26_RS13520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHX26_RS13525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CHX26_RS13530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHX26_RS13555	COG3724	N-succinylarginine dihydrolase activity
CHX26_RS13575	COG1970	mechanosensitive ion channel activity
CHX26_RS13585	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CHX26_RS13595	COG0494	nUDIX hydrolase
CHX26_RS13610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHX26_RS13620	COG4181	ATPase activity
CHX26_RS13625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CHX26_RS13640	COG1217	gtp-binding protein TYPA
CHX26_RS13645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHX26_RS13680	COG2308	Evidence 4 Homologs of previously reported genes of
CHX26_RS13685	COG0596	Alpha beta hydrolase
CHX26_RS13685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHX26_RS13685	COG2226	methyltransferase
CHX26_RS13695	COG0556	nucleotide-excision repair
CHX26_RS13715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CHX26_RS13730	COG0181	hydroxymethylbilane synthase activity
CHX26_RS13735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHX26_RS13740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHX26_RS13750	COG2304	oxidoreductase activity
CHX26_RS13765	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS13800	COG1294	oxidase, subunit
CHX26_RS13810	COG0450	alkyl hydroperoxide reductase
CHX26_RS13820	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHX26_RS13845	COG0450	alkyl hydroperoxide reductase
CHX26_RS13850	COG0640	Transcriptional regulator
CHX26_RS13860	COG1802	Transcriptional regulator
CHX26_RS13865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHX26_RS13875	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CHX26_RS13880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHX26_RS13885	COG1335	isochorismatase
CHX26_RS13890	COG1858	cytochrome C peroxidase
CHX26_RS13935	COG4585	Histidine kinase
CHX26_RS13950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHX26_RS13950	COG1213	nucleotidyl transferase
CHX26_RS13960	COG0438	transferase activity, transferring glycosyl groups
CHX26_RS13965	COG1260	myo-inositol-1-phosphate synthase
CHX26_RS13970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CHX26_RS13995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CHX26_RS14005	COG0297	glycogen (starch) synthase activity
CHX26_RS14040	COG1595	DNA-templated transcription, initiation
CHX26_RS14055	COG3220	belongs to the UPF0276 family
CHX26_RS14075	COG0842	Transport permease protein
CHX26_RS14095	COG1185	polyribonucleotide nucleotidyltransferase activity
CHX26_RS14100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHX26_RS14105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHX26_RS14110	COG1435	thymidine kinase activity
CHX26_RS14120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHX26_RS14135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CHX26_RS14150	COG0779	Required for maturation of 30S ribosomal subunits
CHX26_RS14165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CHX26_RS14175	COG1842	Phage shock protein A
CHX26_RS14210	COG2166	iron-sulfur cluster assembly
CHX26_RS14250	COG0824	Thioesterase
CHX26_RS14255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CHX26_RS14265	COG0066	3-isopropylmalate dehydratase activity
CHX26_RS14280	COG0271	Belongs to the BolA IbaG family
CHX26_RS14285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CHX26_RS14300	COG0523	cobalamin synthesis protein
CHX26_RS14310	COG1136	(ABC) transporter
CHX26_RS14335	COG0248	Ppx GppA phosphatase
CHX26_RS14340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CHX26_RS14345	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CHX26_RS14365	COG3451	type IV secretory pathway VirB4
CHX26_RS14370	COG3702	type iv secretory pathway
CHX26_RS14380	COG0741	lytic transglycosylase activity
CHX26_RS14380	COG0739	heme binding
CHX26_RS14380	COG1196	nuclear chromosome segregation
CHX26_RS14405	COG1846	Transcriptional regulator
CHX26_RS14410	COG0745	RESPONSE REGULATOR receiver
CHX26_RS14415	COG1028	Short-chain dehydrogenase reductase Sdr
CHX26_RS14420	COG1960	acyl-CoA dehydrogenase activity
CHX26_RS14435	COG1840	ABC-type Fe3 transport system, periplasmic component
CHX26_RS14440	COG3842	ATPase activity
CHX26_RS14445	COG1178	ABC-type Fe3 transport system permease component
CHX26_RS14450	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CHX26_RS14455	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CHX26_RS14465	COG2197	response regulator
CHX26_RS14505	COG1063	alcohol dehydrogenase
CHX26_RS14510	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CHX26_RS14515	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CHX26_RS14520	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CHX26_RS14550	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CHX26_RS14555	COG0644	oxidoreductase
CHX26_RS14560	COG2211	Major facilitator Superfamily
CHX26_RS14565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CHX26_RS14585	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CHX26_RS14590	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CHX26_RS14595	COG1429	ligase activity, forming nitrogen-metal bonds
CHX26_RS14600	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CHX26_RS14635	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CHX26_RS14645	COG0156	8-amino-7-oxononanoate synthase activity
CHX26_RS14655	COG1082	Xylose isomerase domain protein TIM barrel
CHX26_RS14660	COG0366	Alpha amylase catalytic
CHX26_RS14675	COG0366	Alpha amylase catalytic
CHX26_RS14715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHX26_RS14720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHX26_RS14735	COG1132	(ABC) transporter
CHX26_RS14750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CHX26_RS14755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHX26_RS14760	COG2264	protein methyltransferase activity
CHX26_RS14775	COG0154	amidase activity
CHX26_RS14780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHX26_RS14790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CHX26_RS14795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CHX26_RS14810	COG0546	phosphoglycolate phosphatase activity
CHX26_RS14840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CHX26_RS14875	COG0730	response to heat
CHX26_RS14885	COG1215	transferase activity, transferring glycosyl groups
CHX26_RS14905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CHX26_RS14910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CHX26_RS14920	COG3023	N-Acetylmuramoyl-L-alanine amidase
CHX26_RS14935	COG0564	pseudouridine synthase activity
CHX26_RS14940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHX26_RS14950	COG1473	amidohydrolase
CHX26_RS14965	COG1595	DNA-templated transcription, initiation
CHX26_RS14975	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CHX26_RS14980	COG2852	Protein conserved in bacteria
CHX26_RS14985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHX26_RS14990	COG0740	serine-type endopeptidase activity
CHX26_RS14995	COG0154	amidase activity
CHX26_RS15005	COG0544	peptidyl-prolyl cis-trans isomerase activity
CHX26_RS15020	COG1160	GTP binding
CHX26_RS15030	COG2193	ferroxidase activity
CHX26_RS15040	COG2311	Membrane
CHX26_RS15065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CHX26_RS15070	COG0540	Belongs to the ATCase OTCase family
CHX26_RS15075	COG0616	signal peptide processing
CHX26_RS15095	COG3128	pkhd-type hydroxylase
CHX26_RS15110	COG1309	transcriptional regulator
CHX26_RS15120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CHX26_RS15125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CHX26_RS15145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHX26_RS15155	COG0037	tRNA processing
CHX26_RS15170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHX26_RS15205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CHX26_RS15215	COG1902	pentaerythritol trinitrate reductase activity
CHX26_RS15225	COG0321	lipoyl(octanoyl) transferase activity
CHX26_RS15240	COG1393	Belongs to the ArsC family
CHX26_RS15245	COG4774	siderophore transport
CHX26_RS15250	COG2080	2 iron, 2 sulfur cluster binding
CHX26_RS15255	COG0235	Class ii aldolase
CHX26_RS15260	COG0534	Mate efflux family protein
CHX26_RS15265	COG2198	Histidine kinase
CHX26_RS15265	COG0643	Histidine kinase
CHX26_RS15275	COG0745	RESPONSE REGULATOR receiver
CHX26_RS15290	COG3300	MHYT domain
CHX26_RS15290	COG5001	Diguanylate cyclase
CHX26_RS15300	COG0840	transmembrane signaling receptor activity
CHX26_RS15350	COG5265	(ABC) transporter
CHX26_RS15355	COG0823	Involved in the tonB-independent uptake of proteins
CHX26_RS15355	COG1506	peptidase
CHX26_RS15355	COG4946	Tricorn protease homolog
CHX26_RS15365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CHX26_RS15370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CHX26_RS15395	COG0629	single-stranded DNA binding
CHX26_RS15410	COG1999	signal sequence binding
CHX26_RS15445	COG1448	Aminotransferase
CHX26_RS15475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CHX26_RS15480	COG0728	peptidoglycan biosynthetic process
CHX26_RS15485	COG0180	Tryptophanyl-tRNA synthetase
CHX26_RS15495	COG0756	dUTP diphosphatase activity
CHX26_RS15500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHX26_RS15505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CHX26_RS15510	COG2226	methyltransferase
CHX26_RS15515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CHX26_RS15520	COG0268	Binds directly to 16S ribosomal RNA