locus-tag	class	description
PORAS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PORAS_RS00020	COG0525	valine-tRNA ligase activity
PORAS_RS00040	COG4771	TonB-dependent receptor
PORAS_RS00085	COG1797	cobyrinic acid a,c-diamide synthase activity
PORAS_RS00090	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PORAS_RS00095	COG1120	ATPase activity
PORAS_RS00100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PORAS_RS00115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PORAS_RS00115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PORAS_RS00120	COG0142	geranyltranstransferase activity
PORAS_RS00130	COG0719	Fe-S assembly protein
PORAS_RS00135	COG0396	ATPase activity
PORAS_RS00140	COG0719	Fe-S assembly protein
PORAS_RS00145	COG0697	spore germination
PORAS_RS00155	COG4771	TonB-dependent receptor
PORAS_RS00185	COG1217	gtp-binding protein TYPA
PORAS_RS00200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PORAS_RS00220	COG0612	Peptidase, M16
PORAS_RS00240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PORAS_RS00270	COG0556	nucleotide-excision repair
PORAS_RS00275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PORAS_RS00285	COG1760	l-serine dehydratase
PORAS_RS00290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PORAS_RS00340	COG0459	protein refolding
PORAS_RS00345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PORAS_RS00350	COG3681	Belongs to the UPF0597 family
PORAS_RS00365	COG1271	oxidase subunit
PORAS_RS00375	COG1438	arginine binding
PORAS_RS00385	COG3590	peptidase
PORAS_RS00395	COG1854	S-ribosylhomocysteine lyase activity
PORAS_RS00415	COG3409	Peptidoglycan-binding domain 1 protein
PORAS_RS00415	COG0793	Belongs to the peptidase S41A family
PORAS_RS00440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PORAS_RS00450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PORAS_RS00465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PORAS_RS00470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PORAS_RS00480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PORAS_RS00485	COG1834	amidinotransferase
PORAS_RS00490	COG2226	methyltransferase
PORAS_RS00525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PORAS_RS00550	COG0792	nuclease activity
PORAS_RS00580	COG1774	PSP1 C-terminal conserved region
PORAS_RS00605	COG0463	Glycosyl transferase, family 2
PORAS_RS00610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PORAS_RS00615	COG0346	lactoylglutathione lyase activity
PORAS_RS00620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PORAS_RS00630	COG4770	biotin carboxylase activity
PORAS_RS00645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PORAS_RS00660	COG0714	Associated with various cellular activities
PORAS_RS00695	COG2304	oxidoreductase activity
PORAS_RS00700	COG2304	oxidoreductase activity
PORAS_RS00720	COG0442	prolyl-tRNA aminoacylation
PORAS_RS00725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PORAS_RS00730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PORAS_RS00740	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PORAS_RS00745	COG0009	L-threonylcarbamoyladenylate synthase
PORAS_RS00765	COG2166	iron-sulfur cluster assembly
PORAS_RS00775	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PORAS_RS00780	COG0501	Belongs to the peptidase M48B family
PORAS_RS00800	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PORAS_RS00805	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PORAS_RS00810	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PORAS_RS00815	COG1805	sodium ion transport
PORAS_RS00820	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PORAS_RS00830	COG4771	TonB-dependent receptor
PORAS_RS00840	COG0275	rRNA processing
PORAS_RS00850	COG0768	penicillin binding
PORAS_RS00855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PORAS_RS00860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PORAS_RS00865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PORAS_RS00870	COG0772	Belongs to the SEDS family
PORAS_RS00875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PORAS_RS00880	COG2226	methyltransferase
PORAS_RS00885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PORAS_RS00890	COG1702	phosphate starvation-inducible protein PhoH
PORAS_RS00900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PORAS_RS00910	COG1674	ftsk spoiiie
PORAS_RS00920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PORAS_RS00925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PORAS_RS00940	COG0739	heme binding
PORAS_RS00940	COG1196	nuclear chromosome segregation
PORAS_RS00940	COG0741	lytic transglycosylase activity
PORAS_RS00970	COG1492	cobalamin metabolic process
PORAS_RS00985	COG0359	binds to the 23S rRNA
PORAS_RS00985	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PORAS_RS01000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PORAS_RS01050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PORAS_RS01055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PORAS_RS01055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PORAS_RS01060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PORAS_RS01065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PORAS_RS01070	COG1047	Peptidyl-prolyl cis-trans
PORAS_RS01075	COG0826	peptidase U32
PORAS_RS01080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PORAS_RS01090	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PORAS_RS01095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PORAS_RS01105	COG0423	glycine-tRNA ligase activity
PORAS_RS01120	COG2890	protein-(glutamine-N5) methyltransferase activity
PORAS_RS01125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PORAS_RS01125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PORAS_RS01150	COG0737	Belongs to the 5'-nucleotidase family
PORAS_RS01165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PORAS_RS01165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PORAS_RS01195	COG0151	Belongs to the GarS family
PORAS_RS01200	COG0823	Involved in the tonB-independent uptake of proteins
PORAS_RS01200	COG1506	peptidase
PORAS_RS01205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PORAS_RS01205	COG0116	Belongs to the methyltransferase superfamily
PORAS_RS01220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PORAS_RS01225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PORAS_RS01230	COG0428	transporter
PORAS_RS01235	COG0598	Magnesium transport protein CorA
PORAS_RS01245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PORAS_RS01255	COG3341	Caulimovirus viroplasmin
PORAS_RS01255	COG0328	RNA-DNA hybrid ribonuclease activity
PORAS_RS01265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PORAS_RS01270	COG0052	Belongs to the universal ribosomal protein uS2 family
PORAS_RS01275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PORAS_RS01280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PORAS_RS01285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PORAS_RS01285	COG0574	Belongs to the PEP-utilizing enzyme family
PORAS_RS01305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PORAS_RS01310	COG0157	Belongs to the NadC ModD family
PORAS_RS01315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PORAS_RS01320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PORAS_RS01325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PORAS_RS01345	COG3604	Transcriptional regulator
PORAS_RS01350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PORAS_RS01355	COG1480	7TM receptor with intracellular HD hydrolase
PORAS_RS01375	COG3023	N-Acetylmuramoyl-L-alanine amidase
PORAS_RS01445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PORAS_RS01455	COG0572	uridine kinase
PORAS_RS01470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PORAS_RS01485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PORAS_RS01490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PORAS_RS01500	COG0571	ribonuclease III activity
PORAS_RS01530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PORAS_RS01540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PORAS_RS01545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PORAS_RS01560	COG1120	ATPase activity
PORAS_RS01565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PORAS_RS01590	COG0569	domain protein
PORAS_RS01590	COG2985	domain, Protein
PORAS_RS01605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PORAS_RS01610	COG1022	Amp-dependent synthetase and ligase
PORAS_RS01620	COG1983	PspC domain protein
PORAS_RS01630	COG0534	Mate efflux family protein
PORAS_RS01635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PORAS_RS01640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PORAS_RS01645	COG3033	Beta-eliminating lyase
PORAS_RS01650	COG0148	phosphopyruvate hydratase activity
PORAS_RS01675	COG0203	ribosomal protein L17
PORAS_RS01680	COG0202	RNA polymerase activity
PORAS_RS01685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PORAS_RS01690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PORAS_RS01695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PORAS_RS01700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PORAS_RS01705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PORAS_RS01720	COG0200	Binds to the 23S rRNA
PORAS_RS01725	COG1841	ribosomal large subunit assembly
PORAS_RS01730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PORAS_RS01735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PORAS_RS01740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PORAS_RS01745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PORAS_RS01750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PORAS_RS01755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PORAS_RS01760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PORAS_RS01765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PORAS_RS01770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PORAS_RS01775	COG0255	Belongs to the universal ribosomal protein uL29 family
PORAS_RS01780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PORAS_RS01785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PORAS_RS01795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PORAS_RS01800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PORAS_RS01805	COG0089	rRNA binding
PORAS_RS01810	COG0088	Forms part of the polypeptide exit tunnel
PORAS_RS01815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PORAS_RS01820	COG0051	transcription antitermination factor activity, RNA binding
PORAS_RS01825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PORAS_RS01830	COG0049	tRNA binding
PORAS_RS01835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PORAS_RS01840	COG1011	Hydrolase
PORAS_RS01845	COG0823	Involved in the tonB-independent uptake of proteins
PORAS_RS01845	COG1506	peptidase
PORAS_RS01905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PORAS_RS01915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PORAS_RS01920	COG0284	orotidine-5'-phosphate decarboxylase activity
PORAS_RS01925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PORAS_RS01930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PORAS_RS01930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PORAS_RS01935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PORAS_RS01940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PORAS_RS01940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PORAS_RS01955	COG1185	polyribonucleotide nucleotidyltransferase activity
PORAS_RS01960	COG0738	Major facilitator superfamily
PORAS_RS01975	COG2096	Adenosyltransferase
PORAS_RS02005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PORAS_RS02010	COG2151	metal-sulfur cluster biosynthetic enzyme
PORAS_RS02015	COG3591	Belongs to the peptidase S1B family
PORAS_RS02020	COG2954	triphosphatase activity
PORAS_RS02045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PORAS_RS02050	COG3344	reverse transcriptase
PORAS_RS02070	COG2197	response regulator
PORAS_RS02080	COG0513	Belongs to the DEAD box helicase family
PORAS_RS02085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PORAS_RS02090	COG4413	Urea transporter
PORAS_RS02095	COG4591	ABC-type transport system involved in lipoprotein release permease component
PORAS_RS02100	COG0488	(ABC) transporter
PORAS_RS02105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PORAS_RS02115	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PORAS_RS02120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PORAS_RS02125	COG0745	RESPONSE REGULATOR receiver
PORAS_RS02130	COG0802	atpase or kinase
PORAS_RS02170	COG1012	belongs to the aldehyde dehydrogenase family
PORAS_RS02175	COG1454	alcohol dehydrogenase
PORAS_RS02180	COG0427	acetyl-CoA hydrolase
PORAS_RS02205	COG0445	tRNA wobble uridine modification
PORAS_RS02210	COG0322	excinuclease ABC activity
PORAS_RS02215	COG1490	D-aminoacyl-tRNA deacylase activity
PORAS_RS02225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PORAS_RS02230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PORAS_RS02235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PORAS_RS02260	COG0297	glycogen (starch) synthase activity
PORAS_RS02270	COG0193	aminoacyl-tRNA hydrolase activity
PORAS_RS02275	COG0791	NLP P60 protein
PORAS_RS02285	COG1151	hydroxylamine reductase activity
PORAS_RS02305	COG0842	Transport permease protein
PORAS_RS02310	COG0842	Transport permease protein
PORAS_RS02330	COG0811	peptide transport
PORAS_RS02335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PORAS_RS02345	COG0534	Mate efflux family protein
PORAS_RS02360	COG4591	ABC-type transport system involved in lipoprotein release permease component
PORAS_RS02365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PORAS_RS02380	COG0563	adenylate kinase activity
PORAS_RS02385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PORAS_RS02390	COG0363	glucosamine-6-phosphate deaminase activity
PORAS_RS02395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PORAS_RS02420	COG3591	Belongs to the peptidase S1B family
PORAS_RS02425	COG0336	Belongs to the RNA methyltransferase TrmD family
PORAS_RS02435	COG0590	tRNA wobble adenosine to inosine editing
PORAS_RS02440	COG0793	Belongs to the peptidase S41A family
PORAS_RS02445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PORAS_RS02450	COG0626	cystathionine gamma-synthase activity
PORAS_RS02470	COG2095	MarC family integral membrane protein
PORAS_RS02475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PORAS_RS02485	COG0006	proline dipeptidase activity
PORAS_RS02500	COG0297	glycogen (starch) synthase activity
PORAS_RS02505	COG0674	pyruvate-flavodoxin oxidoreductase activity
PORAS_RS02505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PORAS_RS02510	COG1013	pyruvate-flavodoxin oxidoreductase activity
PORAS_RS02515	COG0495	leucyl-tRNA aminoacylation
PORAS_RS02520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PORAS_RS02530	COG0671	phosphoesterase, PA-phosphatase related
PORAS_RS02545	COG2985	domain, Protein
PORAS_RS02545	COG0569	domain protein
PORAS_RS02555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PORAS_RS02560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PORAS_RS02560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PORAS_RS02585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PORAS_RS02605	COG0475	glutathione-regulated potassium exporter activity
PORAS_RS02625	COG2176	DNA-directed DNA polymerase activity
PORAS_RS02625	COG5002	protein histidine kinase activity
PORAS_RS02640	COG0497	DNA recombination
PORAS_RS02645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PORAS_RS02650	COG0251	oxidation-reduction process
PORAS_RS02665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PORAS_RS02680	COG0237	dephospho-CoA kinase activity
PORAS_RS02695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PORAS_RS02705	COG0018	arginyl-trna synthetase
PORAS_RS02710	COG0482	sulfurtransferase activity
PORAS_RS02725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PORAS_RS02735	COG0254	rRNA binding
PORAS_RS02755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PORAS_RS02760	COG1216	Glycosyl transferase, family 2
PORAS_RS02780	COG1216	Glycosyl transferase, family 2
PORAS_RS02790	COG1607	acyl-coa hydrolase
PORAS_RS02795	COG3246	L-lysine catabolic process to acetate
PORAS_RS02800	COG0604	alcohol dehydrogenase
PORAS_RS02815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PORAS_RS02820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PORAS_RS02825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PORAS_RS02835	COG1960	acyl-CoA dehydrogenase activity
PORAS_RS02840	COG2086	electron transfer activity
PORAS_RS02845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PORAS_RS02850	COG1024	Enoyl-CoA hydratase
PORAS_RS02855	COG1250	3-hydroxyacyl-CoA dehydrogenase
PORAS_RS02870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PORAS_RS02875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PORAS_RS02885	COG1940	carbohydrate kinase activity
PORAS_RS02895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PORAS_RS02900	COG0252	asparaginase activity
PORAS_RS02945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PORAS_RS02965	COG0463	Glycosyl transferase, family 2
PORAS_RS03030	COG0823	Involved in the tonB-independent uptake of proteins
PORAS_RS03030	COG1506	peptidase
PORAS_RS03070	COG3344	reverse transcriptase
PORAS_RS03080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PORAS_RS03100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PORAS_RS03120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PORAS_RS03130	COG0427	acetyl-CoA hydrolase
PORAS_RS03155	COG1482	cell wall glycoprotein biosynthetic process
PORAS_RS03170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PORAS_RS03180	COG0180	Tryptophanyl-tRNA synthetase
PORAS_RS03220	COG0492	ferredoxin-NADP+ reductase activity
PORAS_RS03225	COG4657	Part of a membrane complex involved in electron transport
PORAS_RS03230	COG4660	Part of a membrane complex involved in electron transport
PORAS_RS03235	COG4659	FMN binding
PORAS_RS03240	COG4658	electron transport chain
PORAS_RS03245	COG4656	Part of a membrane complex involved in electron transport
PORAS_RS03250	COG2878	Part of a membrane complex involved in electron transport
PORAS_RS03250	COG1245	4Fe-4S binding domain
PORAS_RS03265	COG1472	Belongs to the glycosyl hydrolase 3 family
PORAS_RS03300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PORAS_RS03305	COG1592	Rubrerythrin
PORAS_RS03330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PORAS_RS03335	COG1918	ferrous iron import across plasma membrane
PORAS_RS03335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PORAS_RS03345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PORAS_RS03355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PORAS_RS03360	COG0569	domain protein
PORAS_RS03375	COG1418	mRNA catabolic process
PORAS_RS03390	COG1530	ribonuclease E activity
PORAS_RS03395	COG0776	regulation of translation
PORAS_RS03405	COG0268	Binds directly to 16S ribosomal RNA
PORAS_RS03415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PORAS_RS03440	COG0772	Belongs to the SEDS family
PORAS_RS03445	COG0768	penicillin binding
PORAS_RS03465	COG0138	bifunctional purine biosynthesis protein purh
PORAS_RS03475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PORAS_RS03480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PORAS_RS03555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PORAS_RS03560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PORAS_RS03565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PORAS_RS03570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PORAS_RS03580	COG0488	(ABC) transporter
PORAS_RS03585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PORAS_RS03590	COG0242	peptide deformylase activity
PORAS_RS03600	COG0488	(ABC) transporter
PORAS_RS03605	COG1132	(ABC) transporter
PORAS_RS03610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PORAS_RS03620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PORAS_RS03665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PORAS_RS03670	COG0085	RNA polymerase activity
PORAS_RS03675	COG0222	ribosome binding
PORAS_RS03680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PORAS_RS03685	COG0081	regulation of translation
PORAS_RS03690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PORAS_RS03700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PORAS_RS03710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PORAS_RS03725	COG4974	Belongs to the 'phage' integrase family
PORAS_RS03735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PORAS_RS03740	COG0402	S-adenosylhomocysteine deaminase activity
PORAS_RS03745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PORAS_RS03790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PORAS_RS03810	COG0545	Peptidyl-prolyl cis-trans isomerase
PORAS_RS03815	COG0545	Peptidyl-prolyl cis-trans isomerase
PORAS_RS03820	COG0545	Peptidyl-prolyl cis-trans isomerase
PORAS_RS03825	COG0124	histidyl-tRNA synthetase
PORAS_RS03830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PORAS_RS03855	COG3118	belongs to the thioredoxin family
PORAS_RS03875	COG1181	Belongs to the D-alanine--D-alanine ligase family
PORAS_RS03880	COG0564	pseudouridine synthase activity
PORAS_RS03925	COG0335	large ribosomal subunit rRNA binding
PORAS_RS03935	COG4464	protein tyrosine phosphatase activity
PORAS_RS03965	COG3344	reverse transcriptase
PORAS_RS03970	COG0339	signal peptide processing
PORAS_RS03995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PORAS_RS04005	COG0741	lytic transglycosylase activity
PORAS_RS04005	COG1388	LysM domain
PORAS_RS04015	COG1475	DNA binding
PORAS_RS04020	COG1192	Involved in chromosome partitioning
PORAS_RS04035	COG1131	(ABC) transporter
PORAS_RS04040	COG1131	(ABC) transporter
PORAS_RS04050	COG1127	ABC transporter
PORAS_RS04055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PORAS_RS04135	COG1970	mechanosensitive ion channel activity
PORAS_RS04140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PORAS_RS04140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PORAS_RS04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PORAS_RS04150	COG0357	Ribosomal RNA small subunit methyltransferase G
PORAS_RS04155	COG0542	response to heat
PORAS_RS04185	COG0358	DNA primase activity
PORAS_RS04190	COG0470	DNA polymerase III
PORAS_RS04215	COG0564	pseudouridine synthase activity
PORAS_RS04240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PORAS_RS04245	COG0516	GMP reductase activity
PORAS_RS04265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PORAS_RS04325	COG3591	Belongs to the peptidase S1B family
PORAS_RS04325	COG1864	DNA RNA non-specific endonuclease
PORAS_RS04355	COG0826	peptidase U32
PORAS_RS04365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PORAS_RS04380	COG0659	secondary active sulfate transmembrane transporter activity
PORAS_RS04395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PORAS_RS04400	COG0557	exoribonuclease II activity
PORAS_RS04405	COG1162	GTPase activity
PORAS_RS04410	COG0233	cytoplasmic translational termination
PORAS_RS04415	COG0528	UMP kinase activity
PORAS_RS04425	COG4589	Belongs to the CDS family
PORAS_RS04430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PORAS_RS04435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
PORAS_RS04465	COG3344	reverse transcriptase
PORAS_RS04475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PORAS_RS04480	COG0716	FMN binding
PORAS_RS04495	COG0860	N-Acetylmuramoyl-L-alanine amidase
PORAS_RS04510	COG2059	Chromate
PORAS_RS04515	COG2059	Chromate
PORAS_RS04520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PORAS_RS04525	COG1215	transferase activity, transferring glycosyl groups
PORAS_RS04535	COG0386	Belongs to the glutathione peroxidase family
PORAS_RS04550	COG2184	nucleotidyltransferase activity
PORAS_RS04580	COG1518	maintenance of DNA repeat elements
PORAS_RS04585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PORAS_RS04600	COG0215	cysteine-tRNA ligase activity
PORAS_RS04625	COG4948	Mandelate Racemase Muconate Lactonizing
PORAS_RS04630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PORAS_RS04635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PORAS_RS04640	COG1169	isochorismate synthase
PORAS_RS04655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PORAS_RS04660	COG1136	(ABC) transporter
PORAS_RS04665	COG0577	efflux transmembrane transporter activity
PORAS_RS04665	COG1136	(ABC) transporter
PORAS_RS04670	COG1136	(ABC) transporter
PORAS_RS04670	COG0577	efflux transmembrane transporter activity
PORAS_RS04685	COG1131	(ABC) transporter
PORAS_RS04700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PORAS_RS04705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PORAS_RS04710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PORAS_RS04715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PORAS_RS04725	COG3610	response to peptide
PORAS_RS04740	COG0443	Heat shock 70 kDa protein
PORAS_RS04750	COG2217	Heavy metal translocating P-type atpase
PORAS_RS04785	COG0424	maF-like protein
PORAS_RS04790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PORAS_RS04815	COG0438	transferase activity, transferring glycosyl groups
PORAS_RS04825	COG1215	transferase activity, transferring glycosyl groups
PORAS_RS04830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PORAS_RS04835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PORAS_RS04855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PORAS_RS04860	COG1640	4-alpha-glucanotransferase
PORAS_RS04865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PORAS_RS04875	COG0012	GTP binding
PORAS_RS04880	COG0519	Catalyzes the synthesis of GMP from XMP
PORAS_RS04880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PORAS_RS04885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PORAS_RS04890	COG0590	tRNA wobble adenosine to inosine editing
PORAS_RS04900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PORAS_RS04905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PORAS_RS04910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PORAS_RS04915	COG1575	Belongs to the MenA family. Type 1 subfamily
PORAS_RS04920	COG0527	aspartate kinase activity
PORAS_RS04925	COG1136	(ABC) transporter
PORAS_RS04930	COG2249	NAD(P)H dehydrogenase (quinone) activity
PORAS_RS04965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PORAS_RS04970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PORAS_RS04975	COG2022	thiamine diphosphate biosynthetic process
PORAS_RS04980	COG0352	thiamine-phosphate diphosphorylase activity
PORAS_RS04985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PORAS_RS05040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PORAS_RS05055	COG2195	Cleaves the N-terminal amino acid of tripeptides
PORAS_RS05060	COG3344	reverse transcriptase
PORAS_RS05100	COG1668	transmembrane transport
PORAS_RS05105	COG4152	abc transporter atp-binding protein
PORAS_RS05145	COG0438	transferase activity, transferring glycosyl groups
PORAS_RS05155	COG3634	alkyl hydroperoxide reductase activity
PORAS_RS05160	COG0450	alkyl hydroperoxide reductase
PORAS_RS05170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PORAS_RS05180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PORAS_RS05185	COG0514	ATP-dependent DNA helicase (RecQ)
PORAS_RS05190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PORAS_RS05195	COG0740	serine-type endopeptidase activity
PORAS_RS05210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PORAS_RS05210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PORAS_RS05225	COG3275	phosphorelay sensor kinase activity
PORAS_RS05260	COG3266	domain, Protein
PORAS_RS05260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PORAS_RS05265	COG2251	uridine kinase activity
PORAS_RS05265	COG0195	Participates in both transcription termination and antitermination
PORAS_RS05270	COG0779	Required for maturation of 30S ribosomal subunits
PORAS_RS05275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PORAS_RS05280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PORAS_RS05335	COG0671	phosphoesterase, PA-phosphatase related
PORAS_RS05345	COG1136	(ABC) transporter
PORAS_RS05350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PORAS_RS05360	COG1196	nuclear chromosome segregation
PORAS_RS05380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PORAS_RS05385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PORAS_RS05395	COG0606	chelatase, subunit chli
PORAS_RS05405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PORAS_RS05410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PORAS_RS05420	COG0670	Belongs to the BI1 family
PORAS_RS05430	COG0823	Involved in the tonB-independent uptake of proteins
PORAS_RS05430	COG4946	Tricorn protease homolog
PORAS_RS05430	COG1506	peptidase
PORAS_RS05435	COG0326	Molecular chaperone. Has ATPase activity
PORAS_RS05460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PORAS_RS05465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PORAS_RS05480	COG0706	membrane insertase activity
PORAS_RS05485	COG0504	CTP synthase activity
PORAS_RS05490	COG1309	transcriptional regulator
PORAS_RS05495	COG1131	(ABC) transporter
PORAS_RS05515	COG0688	phosphatidylethanolamine metabolic process
PORAS_RS05520	COG1183	phosphatidylcholine synthase activity
PORAS_RS05530	COG0305	Participates in initiation and elongation during chromosome replication
PORAS_RS05535	COG0481	GTPase activity
PORAS_RS05540	COG0217	transcriptional regulatory protein
PORAS_RS05545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PORAS_RS05545	COG0072	phenylalanine-tRNA ligase activity
PORAS_RS05550	COG0668	transmembrane transport
PORAS_RS05560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PORAS_RS05565	COG1663	tetraacyldisaccharide 4'-kinase activity
PORAS_RS05570	COG0616	signal peptide processing
PORAS_RS05580	COG1346	cytolysis
PORAS_RS05585	COG1380	Effector of murein hydrolase LrgA
PORAS_RS05600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PORAS_RS05605	COG0552	protein localization to endoplasmic reticulum
PORAS_RS05615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PORAS_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PORAS_RS05655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PORAS_RS05665	COG1194	a g-specific adenine glycosylase
PORAS_RS05670	COG0205	6-phosphofructokinase activity
PORAS_RS05675	COG2003	Belongs to the UPF0758 family
PORAS_RS05680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PORAS_RS05690	COG0302	gtp cyclohydrolase
PORAS_RS05700	COG0149	triose-phosphate isomerase activity
PORAS_RS05715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PORAS_RS05720	COG1368	sulfuric ester hydrolase activity
PORAS_RS05730	COG1216	Glycosyl transferase, family 2
PORAS_RS05730	COG1442	glycosyl transferase family 8
PORAS_RS05740	COG0187	DNA topoisomerase II activity
PORAS_RS05745	COG2264	protein methyltransferase activity
PORAS_RS05750	COG0534	Mate efflux family protein
PORAS_RS05760	COG1053	succinate dehydrogenase
PORAS_RS05770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PORAS_RS05795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PORAS_RS05800	COG0489	protein tyrosine kinase activity
PORAS_RS05865	COG0343	queuine tRNA-ribosyltransferase activity
PORAS_RS05875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PORAS_RS05880	COG0493	'glutamate synthase
PORAS_RS05885	COG0543	2 iron, 2 sulfur cluster binding
PORAS_RS05895	COG1752	Esterase of the alpha-beta hydrolase superfamily
PORAS_RS05900	COG1295	ribonuclease BN
PORAS_RS05905	COG3588	fructose-bisphosphate aldolase
PORAS_RS05910	COG0724	RNA recognition motif
PORAS_RS05915	COG0517	IMP dehydrogenase activity
PORAS_RS05915	COG0617	tRNA 3'-terminal CCA addition
PORAS_RS05915	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PORAS_RS05930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PORAS_RS05935	COG0586	Pfam SNARE associated Golgi protein
PORAS_RS05940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PORAS_RS05970	COG1429	ligase activity, forming nitrogen-metal bonds
PORAS_RS05975	COG4206	TonB-dependent receptor
PORAS_RS06000	COG0363	glucosamine-6-phosphate deaminase activity
PORAS_RS06005	COG0426	domain, Protein
PORAS_RS06010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PORAS_RS06015	COG0673	inositol 2-dehydrogenase activity
PORAS_RS06020	COG2321	neutral zinc metallopeptidase
PORAS_RS06025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PORAS_RS06025	COG0321	lipoyl(octanoyl) transferase activity
PORAS_RS06030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PORAS_RS06040	COG0632	four-way junction helicase activity
PORAS_RS06055	COG1269	ATP hydrolysis coupled proton transport
PORAS_RS06070	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
PORAS_RS06120	COG0758	DNA mediated transformation
PORAS_RS06125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PORAS_RS06125	COG0047	phosphoribosylformylglycinamidine synthase activity
PORAS_RS06130	COG2045	Belongs to the ComB family
PORAS_RS06140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PORAS_RS06155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PORAS_RS06170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PORAS_RS06195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PORAS_RS06220	COG0698	ribose 5-phosphate isomerase
PORAS_RS06250	COG0737	Belongs to the 5'-nucleotidase family
PORAS_RS06255	COG1570	exodeoxyribonuclease VII activity
PORAS_RS06260	COG2255	four-way junction helicase activity
PORAS_RS06265	COG5002	protein histidine kinase activity
PORAS_RS06270	COG0745	RESPONSE REGULATOR receiver
PORAS_RS06280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PORAS_RS06285	COG0581	inorganic phosphate transmembrane transporter activity
PORAS_RS06290	COG0573	inorganic phosphate transmembrane transporter activity
PORAS_RS06300	COG0360	Binds together with S18 to 16S ribosomal RNA
PORAS_RS06305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PORAS_RS06310	COG0359	binds to the 23S rRNA
PORAS_RS06315	COG1074	ATP-dependent DNA helicase activity
PORAS_RS06325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PORAS_RS06360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PORAS_RS06365	COG0484	heat shock protein binding
PORAS_RS06380	COG0653	protein targeting
PORAS_RS06390	COG0194	GDP metabolic process
PORAS_RS06430	COG2855	membrane
PORAS_RS06445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PORAS_RS06450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PORAS_RS06455	COG0849	cell division
PORAS_RS06465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PORAS_RS06470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PORAS_RS06490	COG0543	2 iron, 2 sulfur cluster binding
PORAS_RS06495	COG0167	dihydroorotate dehydrogenase activity
PORAS_RS06510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PORAS_RS06515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PORAS_RS06520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PORAS_RS06525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PORAS_RS06540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PORAS_RS06545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PORAS_RS06550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PORAS_RS06555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PORAS_RS06565	COG1187	pseudouridine synthase activity
PORAS_RS06570	COG0017	Asparaginyl-tRNA synthetase
PORAS_RS06575	COG0101	tRNA pseudouridine synthase activity
PORAS_RS06615	COG2050	protein possibly involved in aromatic compounds catabolism
PORAS_RS06620	COG2195	Cleaves the N-terminal amino acid of tripeptides
PORAS_RS06630	COG1597	lipid kinase activity
PORAS_RS06635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PORAS_RS06640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PORAS_RS06645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PORAS_RS06655	COG0126	phosphoglycerate kinase activity
PORAS_RS06665	COG1132	(ABC) transporter
PORAS_RS06670	COG2375	cellular response to nickel ion
PORAS_RS06670	COG1132	(ABC) transporter
PORAS_RS06675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PORAS_RS06680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PORAS_RS06685	COG0427	acetyl-CoA hydrolase
PORAS_RS06690	COG1979	alcohol dehydrogenase
PORAS_RS06700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PORAS_RS06710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PORAS_RS06715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PORAS_RS06720	COG1160	GTP binding
PORAS_RS06725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PORAS_RS06730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PORAS_RS06735	COG2986	histidine ammonia-lyase
PORAS_RS06740	COG3404	Formiminotransferase-cyclodeaminase
PORAS_RS06745	COG1228	amidohydrolase
PORAS_RS06795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PORAS_RS06805	COG0588	phosphoglycerate mutase activity
PORAS_RS06865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PORAS_RS06870	COG0798	PFAM Bile acid sodium symporter
PORAS_RS06895	COG1132	(ABC) transporter
PORAS_RS06900	COG1132	(ABC) transporter
PORAS_RS06940	COG4771	TonB-dependent receptor
PORAS_RS06960	COG4974	Belongs to the 'phage' integrase family
PORAS_RS06980	COG0602	queuosine metabolic process
PORAS_RS06985	COG1328	CTP reductase activity
PORAS_RS06985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PORAS_RS06995	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PORAS_RS07020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PORAS_RS07025	COG0509	glycine decarboxylation via glycine cleavage system
PORAS_RS07030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PORAS_RS07035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PORAS_RS07040	COG0756	dUTP diphosphatase activity
PORAS_RS07060	COG0196	riboflavin kinase activity
PORAS_RS07065	COG0009	L-threonylcarbamoyladenylate synthase
PORAS_RS07070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PORAS_RS07075	COG0038	chloride channel
PORAS_RS07080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PORAS_RS07085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PORAS_RS07095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PORAS_RS07115	COG1408	metallophosphoesterase
PORAS_RS07120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PORAS_RS07125	COG4771	TonB-dependent receptor
PORAS_RS07130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PORAS_RS07180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PORAS_RS07185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PORAS_RS07185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PORAS_RS07195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PORAS_RS07205	COG3579	cysteine-type endopeptidase activity
PORAS_RS07210	COG4221	oxidoreductase activity
PORAS_RS07275	COG0228	four-way junction DNA binding
PORAS_RS07285	COG0204	Acyl-transferase
PORAS_RS07290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PORAS_RS07305	COG3956	TIGRFAM MazG family protein
PORAS_RS07320	COG0280	phosphate acetyltransferase
PORAS_RS07320	COG0281	malic enzyme
PORAS_RS07325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PORAS_RS07370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PORAS_RS07375	COG1739	Uncharacterized protein family UPF0029
PORAS_RS07400	COG0860	N-Acetylmuramoyl-L-alanine amidase
PORAS_RS07400	COG1388	LysM domain
PORAS_RS07405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PORAS_RS07415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PORAS_RS07425	COG0166	Belongs to the GPI family
PORAS_RS07435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PORAS_RS07450	COG1704	LemA family
PORAS_RS07455	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PORAS_RS07460	COG0540	Belongs to the ATCase OTCase family
PORAS_RS07480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PORAS_RS07485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PORAS_RS07490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PORAS_RS07505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PORAS_RS07520	COG0406	alpha-ribazole phosphatase activity
PORAS_RS07530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PORAS_RS07535	COG3830	Belongs to the UPF0237 family
PORAS_RS07535	COG0560	Phosphoserine phosphatase
PORAS_RS07550	COG0297	glycogen (starch) synthase activity
PORAS_RS07560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PORAS_RS07735	COG4974	Belongs to the 'phage' integrase family
PORAS_RS07745	COG1528	Iron-storage protein
PORAS_RS07775	COG0811	peptide transport
PORAS_RS07785	COG0084	hydrolase, TatD family'
PORAS_RS07810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PORAS_RS07830	COG3142	Participates in the control of copper homeostasis
PORAS_RS07840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PORAS_RS07845	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PORAS_RS07870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PORAS_RS07870	COG2885	chlorophyll binding
PORAS_RS07900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PORAS_RS07930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PORAS_RS07935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PORAS_RS07945	COG1546	Belongs to the CinA family
PORAS_RS07945	COG1058	Belongs to the CinA family
PORAS_RS07950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PORAS_RS07955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PORAS_RS07970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PORAS_RS07970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PORAS_RS07980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PORAS_RS07990	COG1193	negative regulation of DNA recombination
PORAS_RS07995	COG0750	zinc metalloprotease
PORAS_RS08000	COG0259	pyridoxamine-phosphate oxidase activity
PORAS_RS08005	COG1214	PFAM Peptidase M22, glycoprotease
PORAS_RS08015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PORAS_RS08020	COG1960	acyl-CoA dehydrogenase activity
PORAS_RS08025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PORAS_RS08035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PORAS_RS08040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PORAS_RS08050	COG0512	Glutamine amidotransferase of anthranilate synthase
PORAS_RS08065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PORAS_RS08090	COG2885	chlorophyll binding
PORAS_RS08095	COG2885	chlorophyll binding
PORAS_RS08100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PORAS_RS08120	COG4536	flavin adenine dinucleotide binding
PORAS_RS08130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PORAS_RS08145	COG1373	ATPase (AAA superfamily
PORAS_RS08150	COG2177	Part of the ABC transporter FtsEX involved in
PORAS_RS08160	COG1968	undecaprenyl-diphosphatase activity
PORAS_RS08165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PORAS_RS08170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PORAS_RS08175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PORAS_RS08180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PORAS_RS08205	COG0629	single-stranded DNA binding
PORAS_RS08210	COG4535	Mg2 and Co2 transporter CorC
PORAS_RS08230	COG1250	3-hydroxyacyl-CoA dehydrogenase
PORAS_RS08235	COG1234	tRNA 3'-trailer cleavage
PORAS_RS08245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PORAS_RS08260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PORAS_RS08280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PORAS_RS08285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PORAS_RS08290	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PORAS_RS08350	COG0720	synthase
PORAS_RS08355	COG0602	queuosine metabolic process
PORAS_RS08370	COG1088	dTDP-glucose 4,6-dehydratase activity
PORAS_RS08380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PORAS_RS08390	COG1027	Aspartate ammonia-lyase
PORAS_RS08415	COG2195	Cleaves the N-terminal amino acid of tripeptides
PORAS_RS08420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PORAS_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
PORAS_RS08455	COG2205	protein histidine kinase activity
PORAS_RS08465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PORAS_RS08480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PORAS_RS08485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PORAS_RS08490	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
PORAS_RS08505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PORAS_RS08505	COG1333	cytochrome c biogenesis protein
PORAS_RS08525	COG1730	sister chromatid segregation
PORAS_RS08530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PORAS_RS08535	COG0280	phosphate acetyltransferase
PORAS_RS08545	COG0318	PFAM AMP-dependent synthetase and ligase
PORAS_RS08550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PORAS_RS08555	COG0156	8-amino-7-oxononanoate synthase activity
PORAS_RS08570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PORAS_RS08575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PORAS_RS08575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PORAS_RS08595	COG0037	tRNA processing