locus-tag	class	description
PGS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PGS_RS00020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PGS_RS00025	COG1408	metallophosphoesterase
PGS_RS00045	COG0542	response to heat
PGS_RS00050	COG1472	Belongs to the glycosyl hydrolase 3 family
PGS_RS00055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PGS_RS00090	COG0659	secondary active sulfate transmembrane transporter activity
PGS_RS00100	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PGS_RS00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
PGS_RS00120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PGS_RS00135	COG0295	cytidine deaminase activity
PGS_RS00165	COG3118	belongs to the thioredoxin family
PGS_RS00175	COG0335	large ribosomal subunit rRNA binding
PGS_RS00190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PGS_RS00195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PGS_RS00200	COG0326	Molecular chaperone. Has ATPase activity
PGS_RS00205	COG4589	Belongs to the CDS family
PGS_RS00210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PGS_RS00215	COG0012	GTP binding
PGS_RS00220	COG0739	heme binding
PGS_RS00225	COG2884	Cell division ATP-binding protein ftsE
PGS_RS00230	COG0527	aspartate kinase activity
PGS_RS00235	COG0019	diaminopimelate decarboxylase activity
PGS_RS00240	COG1575	Belongs to the MenA family. Type 1 subfamily
PGS_RS00255	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PGS_RS00265	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PGS_RS00270	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PGS_RS00275	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PGS_RS00310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PGS_RS00350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PGS_RS00355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PGS_RS00365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PGS_RS00370	COG2166	iron-sulfur cluster assembly
PGS_RS00380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PGS_RS00395	COG0582	viral genome integration into host DNA
PGS_RS00430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PGS_RS00430	COG0551	DNA topoisomerase type I activity
PGS_RS00440	COG1309	transcriptional regulator
PGS_RS00445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PGS_RS00575	COG0358	DNA primase activity
PGS_RS00655	COG2233	PERMEase
PGS_RS00660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PGS_RS00670	COG0726	polysaccharide deacetylase
PGS_RS00680	COG1160	GTP binding
PGS_RS00685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PGS_RS00690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PGS_RS00750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PGS_RS00775	COG0252	asparaginase activity
PGS_RS00780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PGS_RS00790	COG0228	four-way junction DNA binding
PGS_RS00820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PGS_RS00825	COG0352	thiamine-phosphate diphosphorylase activity
PGS_RS00830	COG2022	thiamine diphosphate biosynthetic process
PGS_RS00835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PGS_RS00875	COG0513	Belongs to the DEAD box helicase family
PGS_RS00880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PGS_RS00925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PGS_RS00935	COG0180	Tryptophanyl-tRNA synthetase
PGS_RS00950	COG3104	oligopeptide transport
PGS_RS00955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PGS_RS00960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PGS_RS00975	COG2957	Belongs to the agmatine deiminase family
PGS_RS01020	COG0551	DNA topoisomerase type I activity
PGS_RS01020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PGS_RS01025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PGS_RS01030	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PGS_RS01050	COG1442	glycosyl transferase family 8
PGS_RS01050	COG1216	Glycosyl transferase, family 2
PGS_RS01060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PGS_RS01065	COG0776	regulation of translation
PGS_RS01075	COG1739	Uncharacterized protein family UPF0029
PGS_RS01090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PGS_RS01100	COG0438	transferase activity, transferring glycosyl groups
PGS_RS01105	COG0588	phosphoglycerate mutase activity
PGS_RS01120	COG2239	Acts as a magnesium transporter
PGS_RS01125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PGS_RS01135	COG2195	Cleaves the N-terminal amino acid of tripeptides
PGS_RS01140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PGS_RS01145	COG1388	LysM domain
PGS_RS01145	COG3942	CHAP domain
PGS_RS01155	COG1475	DNA binding
PGS_RS01160	COG1192	Involved in chromosome partitioning
PGS_RS01170	COG2957	Belongs to the agmatine deiminase family
PGS_RS01200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PGS_RS01205	COG0552	protein localization to endoplasmic reticulum
PGS_RS01215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PGS_RS01220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PGS_RS01220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PGS_RS01225	COG2890	protein-(glutamine-N5) methyltransferase activity
PGS_RS01230	COG2137	regulation of response to DNA damage stimulus
PGS_RS01235	COG1040	competence protein
PGS_RS01240	COG3590	peptidase
PGS_RS01265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PGS_RS01270	COG0193	aminoacyl-tRNA hydrolase activity
PGS_RS01275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PGS_RS01280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PGS_RS01280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PGS_RS01285	COG0737	Belongs to the 5'-nucleotidase family
PGS_RS01300	COG0446	pyridine nucleotide-disulphide oxidoreductase
PGS_RS01335	COG4206	TonB-dependent receptor
PGS_RS01335	COG1629	transport
PGS_RS01355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PGS_RS01365	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
PGS_RS01380	COG1592	Rubrerythrin
PGS_RS01385	COG0612	Peptidase, M16
PGS_RS01390	COG3152	Membrane
PGS_RS01395	COG0084	hydrolase, TatD family'
PGS_RS01400	COG0594	ribonuclease P activity
PGS_RS01420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PGS_RS01425	COG2116	formate transmembrane transporter activity
PGS_RS01430	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PGS_RS01490	COG2095	MarC family integral membrane protein
PGS_RS01500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PGS_RS01515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PGS_RS01520	COG3876	Protein conserved in bacteria
PGS_RS01550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PGS_RS01555	COG1011	Hydrolase
PGS_RS01565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PGS_RS01595	COG0779	Required for maturation of 30S ribosomal subunits
PGS_RS01600	COG0195	Participates in both transcription termination and antitermination
PGS_RS01615	COG0719	Fe-S assembly protein
PGS_RS01620	COG0396	ATPase activity
PGS_RS01625	COG0719	Fe-S assembly protein
PGS_RS01630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PGS_RS01645	COG0018	arginyl-trna synthetase
PGS_RS01650	COG0482	sulfurtransferase activity
PGS_RS01655	COG0708	Exodeoxyribonuclease III
PGS_RS01660	COG0583	DNA-binding transcription factor activity
PGS_RS01665	COG0629	single-stranded DNA binding
PGS_RS01670	COG1253	flavin adenine dinucleotide binding
PGS_RS01690	COG0572	uridine kinase
PGS_RS01695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PGS_RS01700	COG1027	Aspartate ammonia-lyase
PGS_RS01705	COG0248	Ppx GppA phosphatase
PGS_RS01715	COG1940	carbohydrate kinase activity
PGS_RS01735	COG4974	Belongs to the 'phage' integrase family
PGS_RS01740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PGS_RS01755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PGS_RS01760	COG0590	tRNA wobble adenosine to inosine editing
PGS_RS01770	COG0750	zinc metalloprotease
PGS_RS01775	COG1546	Belongs to the CinA family
PGS_RS01775	COG1058	Belongs to the CinA family
PGS_RS01780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PGS_RS01790	COG0268	Binds directly to 16S ribosomal RNA
PGS_RS01805	COG0557	exoribonuclease II activity
PGS_RS01815	COG1132	(ABC) transporter
PGS_RS01825	COG0259	pyridoxamine-phosphate oxidase activity
PGS_RS01860	COG0564	pseudouridine synthase activity
PGS_RS01870	COG3956	TIGRFAM MazG family protein
PGS_RS01875	COG0187	DNA topoisomerase II activity
PGS_RS01880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PGS_RS01910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PGS_RS01915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PGS_RS01920	COG1136	(ABC) transporter
PGS_RS01930	COG0009	L-threonylcarbamoyladenylate synthase
PGS_RS01935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PGS_RS01970	COG0438	transferase activity, transferring glycosyl groups
PGS_RS01980	COG1131	(ABC) transporter
PGS_RS01990	COG0126	phosphoglycerate kinase activity
PGS_RS01995	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PGS_RS02045	COG1538	Outer membrane efflux protein
PGS_RS02055	COG0577	efflux transmembrane transporter activity
PGS_RS02055	COG1136	(ABC) transporter
PGS_RS02060	COG1136	(ABC) transporter
PGS_RS02060	COG0577	efflux transmembrane transporter activity
PGS_RS02065	COG1136	(ABC) transporter
PGS_RS02090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PGS_RS02090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PGS_RS02095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PGS_RS02100	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
PGS_RS02125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PGS_RS02130	COG2830	Protein of unknown function (DUF452)
PGS_RS02135	COG0500	methyltransferase
PGS_RS02195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PGS_RS02210	COG1674	ftsk spoiiie
PGS_RS02215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PGS_RS02220	COG0534	Mate efflux family protein
PGS_RS02225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PGS_RS02235	COG2608	mercury ion transmembrane transporter activity
PGS_RS02235	COG2217	Heavy metal translocating P-type atpase
PGS_RS02250	COG1053	succinate dehydrogenase
PGS_RS02260	COG0346	lactoylglutathione lyase activity
PGS_RS02265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PGS_RS02280	COG0511	ligase activity, forming carbon-carbon bonds
PGS_RS02290	COG1196	nuclear chromosome segregation
PGS_RS02305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PGS_RS02315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PGS_RS02315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PGS_RS02330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PGS_RS02335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PGS_RS02340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PGS_RS02370	COG0730	response to heat
PGS_RS02375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PGS_RS02380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PGS_RS02390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PGS_RS02395	COG0714	Associated with various cellular activities
PGS_RS02435	COG0671	phosphoesterase, PA-phosphatase related
PGS_RS02440	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PGS_RS02445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PGS_RS02455	COG1480	7TM receptor with intracellular HD hydrolase
PGS_RS02460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PGS_RS02470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PGS_RS02485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PGS_RS02500	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PGS_RS02520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PGS_RS02540	COG1429	ligase activity, forming nitrogen-metal bonds
PGS_RS02545	COG4771	TonB-dependent receptor
PGS_RS02570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PGS_RS02585	COG0826	peptidase U32
PGS_RS02590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PGS_RS02595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PGS_RS02600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PGS_RS02605	COG1968	undecaprenyl-diphosphatase activity
PGS_RS02620	COG3033	Beta-eliminating lyase
PGS_RS02660	COG2985	domain, Protein
PGS_RS02660	COG0569	domain protein
PGS_RS02685	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PGS_RS02695	COG2027	D-alanyl-D-alanine carboxypeptidase
PGS_RS02700	COG2957	Belongs to the agmatine deiminase family
PGS_RS02710	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PGS_RS02720	COG2197	response regulator
PGS_RS02725	COG5002	protein histidine kinase activity
PGS_RS02725	COG2205	protein histidine kinase activity
PGS_RS02725	COG0784	Response regulator, receiver
PGS_RS02735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PGS_RS02745	COG0116	Belongs to the methyltransferase superfamily
PGS_RS02750	COG0823	Involved in the tonB-independent uptake of proteins
PGS_RS02750	COG1506	peptidase
PGS_RS02765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PGS_RS02790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PGS_RS02795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PGS_RS02810	COG1597	lipid kinase activity
PGS_RS02815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PGS_RS02820	COG0438	transferase activity, transferring glycosyl groups
PGS_RS02830	COG0321	lipoyl(octanoyl) transferase activity
PGS_RS02830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PGS_RS02835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PGS_RS02845	COG1620	l-lactate permease
PGS_RS02850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PGS_RS02880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PGS_RS02895	COG1970	mechanosensitive ion channel activity
PGS_RS02915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PGS_RS02920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PGS_RS02950	COG1047	Peptidyl-prolyl cis-trans
PGS_RS02955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PGS_RS02970	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PGS_RS02970	COG1918	ferrous iron import across plasma membrane
PGS_RS03015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PGS_RS03015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PGS_RS03020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PGS_RS03025	COG0357	Ribosomal RNA small subunit methyltransferase G
PGS_RS03035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PGS_RS03055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PGS_RS03060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PGS_RS03065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PGS_RS03075	COG0363	glucosamine-6-phosphate deaminase activity
PGS_RS03080	COG3591	Belongs to the peptidase S1B family
PGS_RS03090	COG1193	negative regulation of DNA recombination
PGS_RS03105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PGS_RS03110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PGS_RS03120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PGS_RS03125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PGS_RS03135	COG1012	belongs to the aldehyde dehydrogenase family
PGS_RS03180	COG1328	CTP reductase activity
PGS_RS03185	COG0602	queuosine metabolic process
PGS_RS03195	COG1530	ribonuclease E activity
PGS_RS03200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PGS_RS03210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PGS_RS03240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PGS_RS03245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PGS_RS03250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PGS_RS03255	COG0305	Participates in initiation and elongation during chromosome replication
PGS_RS03260	COG0481	GTPase activity
PGS_RS03270	COG1309	transcriptional regulator
PGS_RS03280	COG0564	pseudouridine synthase activity
PGS_RS03285	COG2197	response regulator
PGS_RS03300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PGS_RS03315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PGS_RS03320	COG0488	(ABC) transporter
PGS_RS03325	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PGS_RS03330	COG0393	Putative heavy-metal-binding
PGS_RS03345	COG5433	transposase activity
PGS_RS03365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PGS_RS03395	COG0328	RNA-DNA hybrid ribonuclease activity
PGS_RS03395	COG3341	Caulimovirus viroplasmin
PGS_RS03405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PGS_RS03420	COG0443	Heat shock 70 kDa protein
PGS_RS03480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PGS_RS03535	COG1132	(ABC) transporter
PGS_RS03545	COG0793	Belongs to the peptidase S41A family
PGS_RS03550	COG5433	transposase activity
PGS_RS03565	COG0167	dihydroorotate dehydrogenase activity
PGS_RS03575	COG1607	acyl-coa hydrolase
PGS_RS03580	COG3246	L-lysine catabolic process to acetate
PGS_RS03585	COG0604	alcohol dehydrogenase
PGS_RS03600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PGS_RS03605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PGS_RS03610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PGS_RS03620	COG1960	acyl-CoA dehydrogenase activity
PGS_RS03625	COG2086	electron transfer activity
PGS_RS03630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PGS_RS03635	COG1024	Enoyl-CoA hydratase
PGS_RS03645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PGS_RS03650	COG0280	phosphate acetyltransferase
PGS_RS03660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PGS_RS03670	COG1242	4 iron, 4 sulfur cluster binding
PGS_RS03700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PGS_RS03705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PGS_RS03715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PGS_RS03735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PGS_RS03745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PGS_RS03755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PGS_RS03760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PGS_RS03765	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PGS_RS03770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PGS_RS03775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PGS_RS03780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PGS_RS03785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PGS_RS03790	COG0534	Mate efflux family protein
PGS_RS03795	COG0542	response to heat
PGS_RS03810	COG0017	Asparaginyl-tRNA synthetase
PGS_RS03815	COG1187	pseudouridine synthase activity
PGS_RS03825	COG2096	Adenosyltransferase
PGS_RS03835	COG2233	PERMEase
PGS_RS03840	COG1522	sequence-specific DNA binding
PGS_RS03845	COG1570	exodeoxyribonuclease VII activity
PGS_RS03860	COG0525	valine-tRNA ligase activity
PGS_RS03875	COG0492	ferredoxin-NADP+ reductase activity
PGS_RS03880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PGS_RS03930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PGS_RS03935	COG1022	Amp-dependent synthetase and ligase
PGS_RS03960	COG1979	alcohol dehydrogenase
PGS_RS03980	COG1187	pseudouridine synthase activity
PGS_RS03985	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PGS_RS03995	COG1492	cobalamin metabolic process
PGS_RS04020	COG0560	Phosphoserine phosphatase
PGS_RS04025	COG0247	lactate metabolic process
PGS_RS04030	COG1139	Iron-sulfur cluster binding protein
PGS_RS04045	COG0138	bifunctional purine biosynthesis protein purh
PGS_RS04065	COG0768	penicillin binding
PGS_RS04070	COG0772	Belongs to the SEDS family
PGS_RS04110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PGS_RS04120	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PGS_RS04125	COG3421	Type III restriction
PGS_RS04125	COG3421	Type III restriction
PGS_RS04150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PGS_RS04150	COG1116	anion transmembrane transporter activity
PGS_RS04155	COG1194	a g-specific adenine glycosylase
PGS_RS04170	COG0813	purine-nucleoside phosphorylase activity
PGS_RS04175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PGS_RS04185	COG0166	Belongs to the GPI family
PGS_RS04195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PGS_RS04200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PGS_RS04205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PGS_RS04220	COG0720	synthase
PGS_RS04230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PGS_RS04235	COG0789	Transcriptional regulator
PGS_RS04255	COG0860	N-Acetylmuramoyl-L-alanine amidase
PGS_RS04270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PGS_RS04290	COG2194	sulfuric ester hydrolase activity
PGS_RS04305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PGS_RS04315	COG1127	ABC transporter
PGS_RS04320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PGS_RS04370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PGS_RS04375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PGS_RS04400	COG0574	Belongs to the PEP-utilizing enzyme family
PGS_RS04400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PGS_RS04410	COG0427	acetyl-CoA hydrolase
PGS_RS04415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PGS_RS04420	COG1131	(ABC) transporter
PGS_RS04435	COG1725	Transcriptional regulator
PGS_RS04485	COG1090	epimerase
PGS_RS04495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PGS_RS04500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PGS_RS04505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PGS_RS04510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PGS_RS04550	COG0729	surface antigen
PGS_RS04555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PGS_RS04560	COG2226	methyltransferase
PGS_RS04565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PGS_RS04570	COG1702	phosphate starvation-inducible protein PhoH
PGS_RS04580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PGS_RS04590	COG1715	Restriction endonuclease
PGS_RS04595	COG0688	phosphatidylethanolamine metabolic process
PGS_RS04600	COG1183	phosphatidylcholine synthase activity
PGS_RS04610	COG0442	prolyl-tRNA aminoacylation
PGS_RS04625	COG0489	protein tyrosine kinase activity
PGS_RS04630	COG1959	2 iron, 2 sulfur cluster binding
PGS_RS04630	COG1295	ribonuclease BN
PGS_RS04635	COG0196	riboflavin kinase activity
PGS_RS04655	COG0756	dUTP diphosphatase activity
PGS_RS04660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PGS_RS04665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PGS_RS04670	COG0509	glycine decarboxylation via glycine cleavage system
PGS_RS04690	COG4152	abc transporter atp-binding protein
PGS_RS04695	COG1668	transmembrane transport
PGS_RS04705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PGS_RS04715	COG2252	PERMEase
PGS_RS04720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PGS_RS04725	COG1032	radical SAM domain protein
PGS_RS04730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PGS_RS04755	COG2204	response regulator
PGS_RS04760	COG0802	atpase or kinase
PGS_RS04770	COG1435	thymidine kinase activity
PGS_RS04775	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
PGS_RS04780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PGS_RS04785	COG4591	ABC-type transport system involved in lipoprotein release permease component
PGS_RS04790	COG0463	Glycosyl transferase, family 2
PGS_RS04795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PGS_RS04805	COG2246	polysaccharide biosynthetic process
PGS_RS04835	COG3681	Belongs to the UPF0597 family
PGS_RS04855	COG3537	Alpha-1,2-mannosidase
PGS_RS04865	COG1271	oxidase subunit
PGS_RS04870	COG1294	oxidase, subunit
PGS_RS04875	COG1752	Esterase of the alpha-beta hydrolase superfamily
PGS_RS04880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PGS_RS04885	COG3250	beta-galactosidase activity
PGS_RS04895	COG2003	Belongs to the UPF0758 family
PGS_RS04900	COG1151	hydroxylamine reductase activity
PGS_RS04905	COG1785	Belongs to the alkaline phosphatase family
PGS_RS04910	COG0006	proline dipeptidase activity
PGS_RS04920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PGS_RS04940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PGS_RS04945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PGS_RS04960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PGS_RS04970	COG4974	Belongs to the 'phage' integrase family
PGS_RS04980	COG1910	domain protein
PGS_RS05000	COG3843	relaxase mobilization nuclease domain protein
PGS_RS05015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PGS_RS05060	COG3550	peptidyl-serine autophosphorylation
PGS_RS05065	COG3550	peptidyl-serine autophosphorylation
PGS_RS05070	COG1396	sequence-specific DNA binding
PGS_RS05115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PGS_RS05120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PGS_RS05120	COG0551	DNA topoisomerase type I activity
PGS_RS05365	COG0632	four-way junction helicase activity
PGS_RS05375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PGS_RS05380	COG0673	inositol 2-dehydrogenase activity
PGS_RS05385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PGS_RS05390	COG0426	domain, Protein
PGS_RS05395	COG0363	glucosamine-6-phosphate deaminase activity
PGS_RS05400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PGS_RS05410	COG0517	IMP dehydrogenase activity
PGS_RS05410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PGS_RS05410	COG0617	tRNA 3'-terminal CCA addition
PGS_RS05415	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PGS_RS05430	COG0495	leucyl-tRNA aminoacylation
PGS_RS05435	COG0670	Belongs to the BI1 family
PGS_RS05440	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PGS_RS05445	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
PGS_RS05455	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PGS_RS05460	COG0563	adenylate kinase activity
PGS_RS05465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PGS_RS05490	COG0084	hydrolase, TatD family'
PGS_RS05500	COG0811	peptide transport
PGS_RS05520	COG1214	PFAM Peptidase M22, glycoprotease
PGS_RS05525	COG2086	electron transfer activity
PGS_RS05530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PGS_RS05535	COG1960	acyl-CoA dehydrogenase activity
PGS_RS05560	COG1640	4-alpha-glucanotransferase
PGS_RS05565	COG1185	polyribonucleotide nucleotidyltransferase activity
PGS_RS05570	COG0544	peptidyl-prolyl cis-trans isomerase activity
PGS_RS05615	COG0101	tRNA pseudouridine synthase activity
PGS_RS05625	COG0826	peptidase U32
PGS_RS05630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PGS_RS05640	COG1216	Glycosyl transferase, family 2
PGS_RS05650	COG2204	response regulator
PGS_RS05655	COG4191	Histidine kinase
PGS_RS05665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PGS_RS05675	COG1234	tRNA 3'-trailer cleavage
PGS_RS05690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PGS_RS05695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PGS_RS05720	COG0564	pseudouridine synthase activity
PGS_RS05725	COG1181	Belongs to the D-alanine--D-alanine ligase family
PGS_RS05740	COG1011	Hydrolase
PGS_RS05745	COG1506	peptidase
PGS_RS05745	COG0823	Involved in the tonB-independent uptake of proteins
PGS_RS05750	COG0791	NLP P60 protein
PGS_RS05755	COG0745	RESPONSE REGULATOR receiver
PGS_RS05760	COG5002	protein histidine kinase activity
PGS_RS05780	COG3142	Participates in the control of copper homeostasis
PGS_RS05785	COG0512	Glutamine amidotransferase of anthranilate synthase
PGS_RS05795	COG0545	Peptidyl-prolyl cis-trans isomerase
PGS_RS05810	COG4771	TonB-dependent receptor
PGS_RS05820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PGS_RS05830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PGS_RS05835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PGS_RS05840	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
PGS_RS05860	COG2885	chlorophyll binding
PGS_RS05865	COG2885	chlorophyll binding
PGS_RS05880	COG0427	acetyl-CoA hydrolase
PGS_RS05885	COG1454	alcohol dehydrogenase
PGS_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
PGS_RS05900	COG1136	(ABC) transporter
PGS_RS05945	COG4221	oxidoreductase activity
PGS_RS05960	COG1120	ATPase activity
PGS_RS05975	COG4822	anaerobic cobalamin biosynthetic process
PGS_RS05980	COG4771	TonB-dependent receptor
PGS_RS05990	COG3250	beta-galactosidase activity
PGS_RS05995	COG0673	inositol 2-dehydrogenase activity
PGS_RS06015	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PGS_RS06020	COG0424	maF-like protein
PGS_RS06025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PGS_RS06035	COG3830	Belongs to the UPF0237 family
PGS_RS06035	COG0560	Phosphoserine phosphatase
PGS_RS06070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PGS_RS06075	COG1120	ATPase activity
PGS_RS06090	COG0616	signal peptide processing
PGS_RS06095	COG1663	tetraacyldisaccharide 4'-kinase activity
PGS_RS06100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PGS_RS06105	COG0534	Mate efflux family protein
PGS_RS06110	COG2264	protein methyltransferase activity
PGS_RS06115	COG0693	protein deglycase activity
PGS_RS06130	COG0811	peptide transport
PGS_RS06135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PGS_RS06140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PGS_RS06150	COG0724	RNA recognition motif
PGS_RS06160	COG0302	gtp cyclohydrolase
PGS_RS06170	COG0149	triose-phosphate isomerase activity
PGS_RS06185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PGS_RS06190	COG3634	alkyl hydroperoxide reductase activity
PGS_RS06210	COG1217	gtp-binding protein TYPA
PGS_RS06250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PGS_RS06255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PGS_RS06265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PGS_RS06265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PGS_RS06275	COG0359	binds to the 23S rRNA
PGS_RS06280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PGS_RS06285	COG0360	Binds together with S18 to 16S ribosomal RNA
PGS_RS06290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PGS_RS06295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PGS_RS06300	COG0254	rRNA binding
PGS_RS06305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PGS_RS06305	COG0519	Catalyzes the synthesis of GMP from XMP
PGS_RS06310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PGS_RS06315	COG2860	membrane
PGS_RS06325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PGS_RS06330	COG0849	cell division
PGS_RS06345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PGS_RS06350	COG0772	Belongs to the SEDS family
PGS_RS06355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PGS_RS06360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PGS_RS06365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PGS_RS06370	COG0768	penicillin binding
PGS_RS06380	COG0275	rRNA processing
PGS_RS06385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PGS_RS06395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PGS_RS06405	COG2985	domain, Protein
PGS_RS06405	COG0569	domain protein
PGS_RS06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PGS_RS06415	COG0402	S-adenosylhomocysteine deaminase activity
PGS_RS06420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PGS_RS06525	COG2195	Cleaves the N-terminal amino acid of tripeptides
PGS_RS06565	COG2720	vancomycin resistance protein
PGS_RS06570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PGS_RS06570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PGS_RS06575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PGS_RS06580	COG0505	Belongs to the CarA family
PGS_RS06590	COG0706	membrane insertase activity
PGS_RS06595	COG0504	CTP synthase activity
PGS_RS06600	COG0517	IMP dehydrogenase activity
PGS_RS06600	COG0516	GMP reductase activity
PGS_RS06605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PGS_RS06610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PGS_RS06615	COG0459	protein refolding
PGS_RS06630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PGS_RS06645	COG0653	protein targeting
PGS_RS06655	COG0194	GDP metabolic process
PGS_RS06660	COG2715	membrane protein required for spore maturation
PGS_RS06665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PGS_RS06670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PGS_RS06685	COG2957	Belongs to the agmatine deiminase family
PGS_RS06690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PGS_RS06700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PGS_RS06710	COG0343	queuine tRNA-ribosyltransferase activity
PGS_RS06720	COG1854	S-ribosylhomocysteine lyase activity
PGS_RS06725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PGS_RS06740	COG3591	Belongs to the peptidase S1B family
PGS_RS06755	COG2255	four-way junction helicase activity
PGS_RS06770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PGS_RS06775	COG1862	Preprotein translocase
PGS_RS06785	COG0237	dephospho-CoA kinase activity
PGS_RS06795	COG0156	8-amino-7-oxononanoate synthase activity
PGS_RS06810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PGS_RS06820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PGS_RS06835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PGS_RS06850	COG1482	cell wall glycoprotein biosynthetic process
PGS_RS06860	COG0735	belongs to the Fur family
PGS_RS06865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PGS_RS06870	COG0285	dihydrofolate synthase activity
PGS_RS06895	COG1253	flavin adenine dinucleotide binding
PGS_RS06915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PGS_RS06920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PGS_RS06925	COG2195	Cleaves the N-terminal amino acid of tripeptides
PGS_RS06965	COG4464	protein tyrosine phosphatase activity
PGS_RS06975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PGS_RS06980	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PGS_RS06980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PGS_RS06985	COG1013	pyruvate-flavodoxin oxidoreductase activity
PGS_RS06990	COG0674	pyruvate-flavodoxin oxidoreductase activity
PGS_RS06990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PGS_RS07090	COG0740	serine-type endopeptidase activity
PGS_RS07095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PGS_RS07100	COG0514	ATP-dependent DNA helicase (RecQ)
PGS_RS07120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PGS_RS07125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PGS_RS07155	COG1418	mRNA catabolic process
PGS_RS07160	COG1774	PSP1 C-terminal conserved region
PGS_RS07170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PGS_RS07180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PGS_RS07185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PGS_RS07190	COG0085	RNA polymerase activity
PGS_RS07195	COG0222	ribosome binding
PGS_RS07200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PGS_RS07205	COG0081	regulation of translation
PGS_RS07210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PGS_RS07230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PGS_RS07250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PGS_RS07255	COG1193	negative regulation of DNA recombination
PGS_RS07260	COG0750	zinc metalloprotease
PGS_RS07265	COG3263	regulation of cellular component size
PGS_RS07270	COG0556	nucleotide-excision repair
PGS_RS07275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PGS_RS07280	COG0052	Belongs to the universal ribosomal protein uS2 family
PGS_RS07285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PGS_RS07300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PGS_RS07320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PGS_RS07340	COG1704	LemA family
PGS_RS07345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PGS_RS07350	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PGS_RS07355	COG0540	Belongs to the ATCase OTCase family
PGS_RS07390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PGS_RS07395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PGS_RS07400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PGS_RS07415	COG0626	cystathionine gamma-synthase activity
PGS_RS07435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PGS_RS07440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PGS_RS07445	COG0463	Glycosyl transferase, family 2
PGS_RS07470	COG1228	amidohydrolase
PGS_RS07485	COG3404	Formiminotransferase-cyclodeaminase
PGS_RS07490	COG2986	histidine ammonia-lyase
PGS_RS07505	COG1703	isobutyryl-CoA mutase activity
PGS_RS07530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PGS_RS07535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PGS_RS07540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PGS_RS07555	COG0463	Glycosyl transferase, family 2
PGS_RS07565	COG1477	protein flavinylation
PGS_RS07570	COG4657	Part of a membrane complex involved in electron transport
PGS_RS07575	COG4660	Part of a membrane complex involved in electron transport
PGS_RS07580	COG4659	FMN binding
PGS_RS07585	COG4658	electron transport chain
PGS_RS07595	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
PGS_RS07595	COG2878	Part of a membrane complex involved in electron transport
PGS_RS07645	COG2059	Chromate
PGS_RS07665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PGS_RS07690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PGS_RS07695	COG1136	(ABC) transporter
PGS_RS07700	COG0577	efflux transmembrane transporter activity
PGS_RS07710	COG0281	malic enzyme
PGS_RS07710	COG0280	phosphate acetyltransferase
PGS_RS07720	COG0698	ribose 5-phosphate isomerase
PGS_RS07725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PGS_RS07745	COG0709	Synthesizes selenophosphate from selenide and ATP
PGS_RS07750	COG1506	peptidase
PGS_RS07750	COG0823	Involved in the tonB-independent uptake of proteins
PGS_RS07755	COG3588	fructose-bisphosphate aldolase
PGS_RS07765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PGS_RS07775	COG1121	(ABC) transporter
PGS_RS07785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PGS_RS07790	COG0571	ribonuclease III activity
PGS_RS07795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PGS_RS07800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PGS_RS07805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PGS_RS07815	COG0606	chelatase, subunit chli
PGS_RS07825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PGS_RS07830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PGS_RS07835	COG0671	phosphoesterase, PA-phosphatase related
PGS_RS07840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PGS_RS07845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PGS_RS07850	COG0484	heat shock protein binding
PGS_RS07855	COG2151	metal-sulfur cluster biosynthetic enzyme
PGS_RS07865	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PGS_RS07870	COG0156	8-amino-7-oxononanoate synthase activity
PGS_RS07920	COG0251	oxidation-reduction process
PGS_RS07925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PGS_RS07945	COG2176	DNA-directed DNA polymerase activity
PGS_RS07945	COG5002	protein histidine kinase activity
PGS_RS07955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PGS_RS07975	COG0716	FMN binding
PGS_RS07980	COG1929	Belongs to the glycerate kinase type-1 family
PGS_RS08005	COG1755	Isoprenylcysteine carboxyl methyltransferase
PGS_RS08020	COG0792	nuclease activity
PGS_RS08035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PGS_RS08040	COG0215	cysteine-tRNA ligase activity
PGS_RS08045	COG1752	Esterase of the alpha-beta hydrolase superfamily
PGS_RS08050	COG1216	Glycosyl transferase, family 2
PGS_RS08050	COG0463	Glycosyl transferase, family 2
PGS_RS08065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PGS_RS08070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PGS_RS08075	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PGS_RS08175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PGS_RS08195	COG1162	GTPase activity
PGS_RS08200	COG0233	cytoplasmic translational termination
PGS_RS08205	COG0528	UMP kinase activity
PGS_RS08225	COG0148	phosphopyruvate hydratase activity
PGS_RS08245	COG1022	Amp-dependent synthetase and ligase
PGS_RS08250	COG0514	ATP-dependent DNA helicase (RecQ)
PGS_RS08260	COG0297	glycogen (starch) synthase activity
PGS_RS08270	COG2211	Major facilitator Superfamily
PGS_RS08275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PGS_RS08300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PGS_RS08310	COG3119	arylsulfatase activity
PGS_RS08350	COG1518	maintenance of DNA repeat elements
PGS_RS08355	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PGS_RS08365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PGS_RS08370	COG1381	Involved in DNA repair and RecF pathway recombination
PGS_RS08375	COG4771	TonB-dependent receptor
PGS_RS08385	COG2855	membrane
PGS_RS08390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PGS_RS08395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PGS_RS08415	COG0142	geranyltranstransferase activity
PGS_RS08420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PGS_RS08430	COG1490	D-aminoacyl-tRNA deacylase activity
PGS_RS08435	COG0322	excinuclease ABC activity
PGS_RS08440	COG0445	tRNA wobble uridine modification
PGS_RS08525	COG0668	transmembrane transport
PGS_RS08535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PGS_RS08560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PGS_RS08565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PGS_RS08595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PGS_RS08600	COG0628	permease
PGS_RS08625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PGS_RS08645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PGS_RS08650	COG0049	tRNA binding
PGS_RS08655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PGS_RS08660	COG0051	transcription antitermination factor activity, RNA binding
PGS_RS08665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PGS_RS08670	COG0088	Forms part of the polypeptide exit tunnel
PGS_RS08675	COG0089	rRNA binding
PGS_RS08680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PGS_RS08685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PGS_RS08690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PGS_RS08695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PGS_RS08700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PGS_RS08705	COG0255	Belongs to the universal ribosomal protein uL29 family
PGS_RS08715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PGS_RS08720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PGS_RS08725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PGS_RS08730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PGS_RS08735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PGS_RS08740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PGS_RS08745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PGS_RS08750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PGS_RS08755	COG1841	ribosomal large subunit assembly
PGS_RS08760	COG0200	Binds to the 23S rRNA
PGS_RS08765	COG0201	protein transport
PGS_RS08775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PGS_RS08780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PGS_RS08785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PGS_RS08790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PGS_RS08795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PGS_RS08800	COG0202	RNA polymerase activity
PGS_RS08805	COG0203	ribosomal protein L17
PGS_RS08820	COG0339	signal peptide processing
PGS_RS08835	COG0475	glutathione-regulated potassium exporter activity
PGS_RS08840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PGS_RS08845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PGS_RS08845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PGS_RS08895	COG1269	ATP hydrolysis coupled proton transport
PGS_RS08930	COG0358	DNA primase activity
PGS_RS08935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PGS_RS08940	COG2249	NAD(P)H dehydrogenase (quinone) activity
PGS_RS08945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PGS_RS08960	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
PGS_RS08965	COG3005	denitrification pathway
PGS_RS08980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PGS_RS08985	COG0406	alpha-ribazole phosphatase activity
PGS_RS08995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PGS_RS09020	COG0493	'glutamate synthase
PGS_RS09025	COG0543	2 iron, 2 sulfur cluster binding
PGS_RS09030	COG0336	Belongs to the RNA methyltransferase TrmD family
PGS_RS09035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PGS_RS09045	COG3023	N-Acetylmuramoyl-L-alanine amidase
PGS_RS09060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PGS_RS09065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PGS_RS09075	COG0037	tRNA processing
PGS_RS09080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PGS_RS09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PGS_RS09115	COG0167	dihydroorotate dehydrogenase activity
PGS_RS09130	COG3852	Histidine kinase
PGS_RS09135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PGS_RS09135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PGS_RS09150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PGS_RS09155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PGS_RS09170	COG1649	PFAM Uncharacterised BCR, COG1649
PGS_RS09175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PGS_RS09200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PGS_RS09200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PGS_RS09205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PGS_RS09210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PGS_RS09210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PGS_RS09215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PGS_RS09220	COG0284	orotidine-5'-phosphate decarboxylase activity
PGS_RS09225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PGS_RS09230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PGS_RS09235	COG1705	Flagellar rod assembly protein muramidase FlgJ
PGS_RS09235	COG1388	LysM domain
PGS_RS09260	COG1760	l-serine dehydratase
PGS_RS09275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PGS_RS09275	COG0517	IMP dehydrogenase activity
PGS_RS09285	COG0783	Belongs to the Dps family
PGS_RS09315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PGS_RS09320	COG0217	transcriptional regulatory protein
PGS_RS09325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PGS_RS09325	COG0072	phenylalanine-tRNA ligase activity
PGS_RS09365	COG1074	ATP-dependent DNA helicase activity
PGS_RS09375	COG0300	oxidoreductase activity
PGS_RS09385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PGS_RS09395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PGS_RS09410	COG0124	histidyl-tRNA synthetase
PGS_RS09415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PGS_RS09420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PGS_RS09430	COG2957	Belongs to the agmatine deiminase family
PGS_RS09435	COG0488	(ABC) transporter
PGS_RS09445	COG0242	peptide deformylase activity
PGS_RS09450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PGS_RS09460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PGS_RS09465	COG0488	(ABC) transporter
PGS_RS09520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PGS_RS09525	COG0569	domain protein
PGS_RS09545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine