locus-tag	class	description
CS545_RS00015	COG1074	ATP-dependent DNA helicase activity
CS545_RS00060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS545_RS00060	COG0072	phenylalanine-tRNA ligase activity
CS545_RS00065	COG0217	transcriptional regulatory protein
CS545_RS00070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CS545_RS00095	COG0783	Belongs to the Dps family
CS545_RS00105	COG0517	IMP dehydrogenase activity
CS545_RS00105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS545_RS00120	COG1760	l-serine dehydratase
CS545_RS00150	COG1388	LysM domain
CS545_RS00150	COG1705	Flagellar rod assembly protein muramidase FlgJ
CS545_RS00155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CS545_RS00160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CS545_RS00165	COG0284	orotidine-5'-phosphate decarboxylase activity
CS545_RS00170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS545_RS00175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CS545_RS00175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CS545_RS00180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS545_RS00185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CS545_RS00185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CS545_RS00210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS545_RS00215	COG1649	PFAM Uncharacterised BCR, COG1649
CS545_RS00230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CS545_RS00235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS545_RS00250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CS545_RS00250	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CS545_RS00255	COG3852	Histidine kinase
CS545_RS00290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS545_RS00310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS545_RS00315	COG0037	tRNA processing
CS545_RS00325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS545_RS00330	COG5433	transposase activity
CS545_RS00340	COG0406	alpha-ribazole phosphatase activity
CS545_RS00350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS545_RS00370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CS545_RS00375	COG0493	'glutamate synthase
CS545_RS00380	COG0543	2 iron, 2 sulfur cluster binding
CS545_RS00385	COG0336	Belongs to the RNA methyltransferase TrmD family
CS545_RS00390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS545_RS00410	COG3023	N-Acetylmuramoyl-L-alanine amidase
CS545_RS00425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS545_RS00435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS00445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CS545_RS00455	COG3119	arylsulfatase activity
CS545_RS00495	COG1518	maintenance of DNA repeat elements
CS545_RS00500	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CS545_RS00505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS545_RS00510	COG1381	Involved in DNA repair and RecF pathway recombination
CS545_RS00515	COG4771	TonB-dependent receptor
CS545_RS00525	COG2855	membrane
CS545_RS00530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CS545_RS00535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CS545_RS00555	COG0142	geranyltranstransferase activity
CS545_RS00570	COG1490	D-aminoacyl-tRNA deacylase activity
CS545_RS00575	COG0322	excinuclease ABC activity
CS545_RS00580	COG0445	tRNA wobble uridine modification
CS545_RS00700	COG0668	transmembrane transport
CS545_RS00710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CS545_RS00735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CS545_RS00740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CS545_RS00755	COG0427	acetyl-CoA hydrolase
CS545_RS00775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS545_RS00780	COG0628	permease
CS545_RS00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CS545_RS00830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CS545_RS00835	COG0049	tRNA binding
CS545_RS00840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CS545_RS00845	COG0051	transcription antitermination factor activity, RNA binding
CS545_RS00850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CS545_RS00855	COG0088	Forms part of the polypeptide exit tunnel
CS545_RS00860	COG0089	rRNA binding
CS545_RS00865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CS545_RS00870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CS545_RS00875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CS545_RS00880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CS545_RS00885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CS545_RS00890	COG0255	Belongs to the universal ribosomal protein uL29 family
CS545_RS00895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CS545_RS00900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CS545_RS00905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CS545_RS00910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CS545_RS00915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CS545_RS00920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CS545_RS00925	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CS545_RS00930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CS545_RS00935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CS545_RS00940	COG1841	ribosomal large subunit assembly
CS545_RS00945	COG0200	Binds to the 23S rRNA
CS545_RS00950	COG0201	protein transport
CS545_RS00960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CS545_RS00965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CS545_RS00970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CS545_RS00975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CS545_RS00980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CS545_RS00985	COG0202	RNA polymerase activity
CS545_RS00990	COG0203	ribosomal protein L17
CS545_RS01020	COG0528	UMP kinase activity
CS545_RS01025	COG0233	cytoplasmic translational termination
CS545_RS01030	COG1162	GTPase activity
CS545_RS01050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CS545_RS01080	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CS545_RS01085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CS545_RS01090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CS545_RS01105	COG0463	Glycosyl transferase, family 2
CS545_RS01105	COG1216	Glycosyl transferase, family 2
CS545_RS01110	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS545_RS01115	COG0215	cysteine-tRNA ligase activity
CS545_RS01120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CS545_RS01135	COG0792	nuclease activity
CS545_RS01155	COG1755	Isoprenylcysteine carboxyl methyltransferase
CS545_RS01185	COG1929	Belongs to the glycerate kinase type-1 family
CS545_RS01190	COG0716	FMN binding
CS545_RS01210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CS545_RS01220	COG5002	protein histidine kinase activity
CS545_RS01220	COG2176	DNA-directed DNA polymerase activity
CS545_RS01235	COG0497	DNA recombination
CS545_RS01240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS545_RS01245	COG0251	oxidation-reduction process
CS545_RS01270	COG0339	signal peptide processing
CS545_RS01285	COG0475	glutathione-regulated potassium exporter activity
CS545_RS01290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CS545_RS01295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS545_RS01295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS545_RS01335	COG1269	ATP hydrolysis coupled proton transport
CS545_RS01375	COG0358	DNA primase activity
CS545_RS01380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CS545_RS01385	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS545_RS01390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS545_RS01400	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CS545_RS01405	COG3005	denitrification pathway
CS545_RS01420	COG0148	phosphopyruvate hydratase activity
CS545_RS01450	COG1022	Amp-dependent synthetase and ligase
CS545_RS01455	COG0514	ATP-dependent DNA helicase (RecQ)
CS545_RS01470	COG0297	glycogen (starch) synthase activity
CS545_RS01480	COG2211	Major facilitator Superfamily
CS545_RS01485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS01505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS01540	COG0156	8-amino-7-oxononanoate synthase activity
CS545_RS01545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CS545_RS01555	COG2151	metal-sulfur cluster biosynthetic enzyme
CS545_RS01560	COG0484	heat shock protein binding
CS545_RS01565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CS545_RS01570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CS545_RS01575	COG0671	phosphoesterase, PA-phosphatase related
CS545_RS01580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CS545_RS01585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CS545_RS01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CS545_RS01615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS545_RS01620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS545_RS01625	COG0571	ribonuclease III activity
CS545_RS01630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS545_RS01640	COG1121	(ABC) transporter
CS545_RS01655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CS545_RS01670	COG3588	fructose-bisphosphate aldolase
CS545_RS01675	COG1506	peptidase
CS545_RS01675	COG0823	Involved in the tonB-independent uptake of proteins
CS545_RS01680	COG0709	Synthesizes selenophosphate from selenide and ATP
CS545_RS01700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CS545_RS01705	COG0698	ribose 5-phosphate isomerase
CS545_RS01715	COG0280	phosphate acetyltransferase
CS545_RS01715	COG0281	malic enzyme
CS545_RS01730	COG0577	efflux transmembrane transporter activity
CS545_RS01735	COG1136	(ABC) transporter
CS545_RS01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS545_RS01760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CS545_RS01780	COG2059	Chromate
CS545_RS01845	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
CS545_RS01845	COG2878	Part of a membrane complex involved in electron transport
CS545_RS01850	COG4656	Part of a membrane complex involved in electron transport
CS545_RS01855	COG4658	electron transport chain
CS545_RS01860	COG4659	FMN binding
CS545_RS01865	COG4660	Part of a membrane complex involved in electron transport
CS545_RS01870	COG4657	Part of a membrane complex involved in electron transport
CS545_RS01875	COG1477	protein flavinylation
CS545_RS01885	COG0463	Glycosyl transferase, family 2
CS545_RS01900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CS545_RS01905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CS545_RS01910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CS545_RS01930	COG1703	isobutyryl-CoA mutase activity
CS545_RS01945	COG2986	histidine ammonia-lyase
CS545_RS01950	COG3404	Formiminotransferase-cyclodeaminase
CS545_RS01965	COG1228	amidohydrolase
CS545_RS01990	COG0463	Glycosyl transferase, family 2
CS545_RS01995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CS545_RS02000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CS545_RS02025	COG0626	cystathionine gamma-synthase activity
CS545_RS02040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CS545_RS02045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CS545_RS02050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CS545_RS02095	COG0540	Belongs to the ATCase OTCase family
CS545_RS02100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CS545_RS02105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS545_RS02110	COG1704	LemA family
CS545_RS02130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CS545_RS02150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CS545_RS02170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CS545_RS02175	COG0052	Belongs to the universal ribosomal protein uS2 family
CS545_RS02180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CS545_RS02185	COG0556	nucleotide-excision repair
CS545_RS02190	COG3263	regulation of cellular component size
CS545_RS02195	COG0750	zinc metalloprotease
CS545_RS02205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CS545_RS02225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CS545_RS02245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CS545_RS02250	COG0081	regulation of translation
CS545_RS02255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CS545_RS02260	COG0222	ribosome binding
CS545_RS02265	COG0085	RNA polymerase activity
CS545_RS02270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CS545_RS02275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS545_RS02285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CS545_RS02295	COG1774	PSP1 C-terminal conserved region
CS545_RS02300	COG1418	mRNA catabolic process
CS545_RS02330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS02335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CS545_RS02350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS545_RS02355	COG0514	ATP-dependent DNA helicase (RecQ)
CS545_RS02360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CS545_RS02365	COG0740	serine-type endopeptidase activity
CS545_RS02465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CS545_RS02465	COG0674	pyruvate-flavodoxin oxidoreductase activity
CS545_RS02470	COG1013	pyruvate-flavodoxin oxidoreductase activity
CS545_RS02475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CS545_RS02475	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CS545_RS02480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS545_RS02490	COG4464	protein tyrosine phosphatase activity
CS545_RS02530	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS545_RS02535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS545_RS02540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CS545_RS02560	COG1253	flavin adenine dinucleotide binding
CS545_RS02585	COG0285	dihydrofolate synthase activity
CS545_RS02590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CS545_RS02595	COG0735	belongs to the Fur family
CS545_RS02605	COG1482	cell wall glycoprotein biosynthetic process
CS545_RS02620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CS545_RS02635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS545_RS02645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CS545_RS02660	COG0156	8-amino-7-oxononanoate synthase activity
CS545_RS02670	COG0237	dephospho-CoA kinase activity
CS545_RS02680	COG1862	Preprotein translocase
CS545_RS02685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CS545_RS02695	COG2255	four-way junction helicase activity
CS545_RS02710	COG3591	Belongs to the peptidase S1B family
CS545_RS02730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS545_RS02735	COG1854	S-ribosylhomocysteine lyase activity
CS545_RS02740	COG0343	queuine tRNA-ribosyltransferase activity
CS545_RS02750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CS545_RS02755	COG1506	peptidase
CS545_RS02755	COG0823	Involved in the tonB-independent uptake of proteins
CS545_RS02760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CS545_RS02785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CS545_RS02790	COG2715	membrane protein required for spore maturation
CS545_RS02795	COG0194	GDP metabolic process
CS545_RS02805	COG0653	protein targeting
CS545_RS02820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CS545_RS02835	COG0459	protein refolding
CS545_RS02840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CS545_RS02845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CS545_RS02865	COG0504	CTP synthase activity
CS545_RS02870	COG0706	membrane insertase activity
CS545_RS02880	COG0505	Belongs to the CarA family
CS545_RS02885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CS545_RS02890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CS545_RS02890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS545_RS02895	COG2720	vancomycin resistance protein
CS545_RS02935	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS545_RS03035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CS545_RS03040	COG0402	S-adenosylhomocysteine deaminase activity
CS545_RS03045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS545_RS03050	COG0569	domain protein
CS545_RS03050	COG2985	domain, Protein
CS545_RS03065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS545_RS03075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CS545_RS03080	COG0275	rRNA processing
CS545_RS03090	COG0768	penicillin binding
CS545_RS03095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS545_RS03100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS545_RS03105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CS545_RS03110	COG0772	Belongs to the SEDS family
CS545_RS03115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS545_RS03120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CS545_RS03130	COG0849	cell division
CS545_RS03135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS545_RS03150	COG2860	membrane
CS545_RS03155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CS545_RS03160	COG0519	Catalyzes the synthesis of GMP from XMP
CS545_RS03160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CS545_RS03165	COG0254	rRNA binding
CS545_RS03170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS545_RS03175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CS545_RS03180	COG0360	Binds together with S18 to 16S ribosomal RNA
CS545_RS03185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CS545_RS03190	COG0359	binds to the 23S rRNA
CS545_RS03200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS545_RS03200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS545_RS03215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CS545_RS03220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CS545_RS03270	COG1217	gtp-binding protein TYPA
CS545_RS03295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CS545_RS03310	COG0149	triose-phosphate isomerase activity
CS545_RS03320	COG0302	gtp cyclohydrolase
CS545_RS03330	COG0724	RNA recognition motif
CS545_RS03340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS545_RS03345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CS545_RS03350	COG0811	peptide transport
CS545_RS03365	COG0693	protein deglycase activity
CS545_RS03370	COG2264	protein methyltransferase activity
CS545_RS03375	COG0534	Mate efflux family protein
CS545_RS03380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CS545_RS03385	COG1663	tetraacyldisaccharide 4'-kinase activity
CS545_RS03390	COG0616	signal peptide processing
CS545_RS03410	COG1120	ATPase activity
CS545_RS03415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS545_RS03450	COG0560	Phosphoserine phosphatase
CS545_RS03450	COG3830	Belongs to the UPF0237 family
CS545_RS03460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CS545_RS03465	COG0424	maF-like protein
CS545_RS03470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CS545_RS03495	COG0673	inositol 2-dehydrogenase activity
CS545_RS03510	COG4771	TonB-dependent receptor
CS545_RS03515	COG4822	anaerobic cobalamin biosynthetic process
CS545_RS03530	COG1120	ATPase activity
CS545_RS03545	COG4221	oxidoreductase activity
CS545_RS03585	COG1136	(ABC) transporter
CS545_RS03600	COG1012	belongs to the aldehyde dehydrogenase family
CS545_RS03605	COG1454	alcohol dehydrogenase
CS545_RS03610	COG0427	acetyl-CoA hydrolase
CS545_RS03625	COG2885	chlorophyll binding
CS545_RS03630	COG2885	chlorophyll binding
CS545_RS03650	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CS545_RS03655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CS545_RS03660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CS545_RS03670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS545_RS03680	COG4771	TonB-dependent receptor
CS545_RS03690	COG0545	Peptidyl-prolyl cis-trans isomerase
CS545_RS03695	COG0545	Peptidyl-prolyl cis-trans isomerase
CS545_RS03705	COG0512	Glutamine amidotransferase of anthranilate synthase
CS545_RS03710	COG3142	Participates in the control of copper homeostasis
CS545_RS03735	COG5002	protein histidine kinase activity
CS545_RS03740	COG0745	RESPONSE REGULATOR receiver
CS545_RS03745	COG0791	NLP P60 protein
CS545_RS03750	COG0823	Involved in the tonB-independent uptake of proteins
CS545_RS03750	COG1506	peptidase
CS545_RS03755	COG1011	Hydrolase
CS545_RS03775	COG1181	Belongs to the D-alanine--D-alanine ligase family
CS545_RS03780	COG0564	pseudouridine synthase activity
CS545_RS03805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CS545_RS03810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CS545_RS03825	COG1234	tRNA 3'-trailer cleavage
CS545_RS03835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS545_RS03845	COG4191	Histidine kinase
CS545_RS03850	COG2204	response regulator
CS545_RS03865	COG1216	Glycosyl transferase, family 2
CS545_RS03875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CS545_RS03880	COG0826	peptidase U32
CS545_RS03895	COG0101	tRNA pseudouridine synthase activity
CS545_RS03935	COG0544	peptidyl-prolyl cis-trans isomerase activity
CS545_RS03940	COG1185	polyribonucleotide nucleotidyltransferase activity
CS545_RS03945	COG1640	4-alpha-glucanotransferase
CS545_RS03970	COG1960	acyl-CoA dehydrogenase activity
CS545_RS03975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS545_RS03980	COG2086	electron transfer activity
CS545_RS03985	COG1214	PFAM Peptidase M22, glycoprotease
CS545_RS04015	COG0811	peptide transport
CS545_RS04025	COG0084	hydrolase, TatD family'
CS545_RS04055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CS545_RS04060	COG0563	adenylate kinase activity
CS545_RS04065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CS545_RS04095	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CS545_RS04100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CS545_RS04105	COG0670	Belongs to the BI1 family
CS545_RS04110	COG0495	leucyl-tRNA aminoacylation
CS545_RS04130	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CS545_RS04135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CS545_RS04135	COG0517	IMP dehydrogenase activity
CS545_RS04135	COG0617	tRNA 3'-terminal CCA addition
CS545_RS04150	COG0363	glucosamine-6-phosphate deaminase activity
CS545_RS04155	COG0426	domain, Protein
CS545_RS04160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CS545_RS04165	COG0673	inositol 2-dehydrogenase activity
CS545_RS04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS545_RS04185	COG0632	four-way junction helicase activity
CS545_RS04235	COG1002	Type II restriction enzyme, methylase subunits
CS545_RS04375	COG0542	response to heat
CS545_RS04440	COG3209	COG3209 Rhs family protein
CS545_RS04465	COG3209	COG3209 Rhs family protein
CS545_RS04490	COG4104	PAAR repeat-containing protein
CS545_RS04490	COG3209	COG3209 Rhs family protein
CS545_RS04630	COG4974	Belongs to the 'phage' integrase family
CS545_RS04635	COG4974	Belongs to the 'phage' integrase family
CS545_RS04695	COG1396	sequence-specific DNA binding
CS545_RS04700	COG3550	peptidyl-serine autophosphorylation
CS545_RS04705	COG3550	peptidyl-serine autophosphorylation
CS545_RS04730	COG1431	PFAM Stem cell self-renewal protein Piwi
CS545_RS04740	COG3843	relaxase mobilization nuclease domain protein
CS545_RS04760	COG1910	domain protein
CS545_RS04770	COG4974	Belongs to the 'phage' integrase family
CS545_RS04790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CS545_RS04805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS545_RS04810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CS545_RS04830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CS545_RS04840	COG0006	proline dipeptidase activity
CS545_RS04845	COG1785	Belongs to the alkaline phosphatase family
CS545_RS04860	COG1151	hydroxylamine reductase activity
CS545_RS04875	COG3250	beta-galactosidase activity
CS545_RS04880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CS545_RS04885	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS545_RS04890	COG1294	oxidase, subunit
CS545_RS04895	COG1271	oxidase subunit
CS545_RS04905	COG3537	Alpha-1,2-mannosidase
CS545_RS04925	COG3681	Belongs to the UPF0597 family
CS545_RS04960	COG2246	polysaccharide biosynthetic process
CS545_RS04970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS545_RS04975	COG0463	Glycosyl transferase, family 2
CS545_RS04980	COG4591	ABC-type transport system involved in lipoprotein release permease component
CS545_RS04985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CS545_RS04990	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CS545_RS04995	COG1435	thymidine kinase activity
CS545_RS05005	COG0802	atpase or kinase
CS545_RS05010	COG2204	response regulator
CS545_RS05035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CS545_RS05040	COG1032	radical SAM domain protein
CS545_RS05045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CS545_RS05050	COG2252	PERMEase
CS545_RS05060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CS545_RS05070	COG1668	transmembrane transport
CS545_RS05075	COG4152	abc transporter atp-binding protein
CS545_RS05095	COG0509	glycine decarboxylation via glycine cleavage system
CS545_RS05100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CS545_RS05105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CS545_RS05110	COG0756	dUTP diphosphatase activity
CS545_RS05130	COG0196	riboflavin kinase activity
CS545_RS05135	COG1959	2 iron, 2 sulfur cluster binding
CS545_RS05135	COG1295	ribonuclease BN
CS545_RS05145	COG0489	protein tyrosine kinase activity
CS545_RS05150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CS545_RS05160	COG0442	prolyl-tRNA aminoacylation
CS545_RS05170	COG1183	phosphatidylcholine synthase activity
CS545_RS05175	COG0688	phosphatidylethanolamine metabolic process
CS545_RS05180	COG1715	Restriction endonuclease
CS545_RS05190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CS545_RS05205	COG1702	phosphate starvation-inducible protein PhoH
CS545_RS05210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CS545_RS05215	COG2226	methyltransferase
CS545_RS05220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CS545_RS05225	COG0729	surface antigen
CS545_RS05260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CS545_RS05265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CS545_RS05270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CS545_RS05275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CS545_RS05285	COG1090	epimerase
CS545_RS05335	COG1725	Transcriptional regulator
CS545_RS05350	COG1131	(ABC) transporter
CS545_RS05355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS545_RS05360	COG0427	acetyl-CoA hydrolase
CS545_RS05370	COG0574	Belongs to the PEP-utilizing enzyme family
CS545_RS05370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CS545_RS05395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS545_RS05400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CS545_RS05410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CS545_RS05430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CS545_RS05435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS545_RS05445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CS545_RS05460	COG2194	sulfuric ester hydrolase activity
CS545_RS05465	COG1438	arginine binding
CS545_RS05480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS545_RS05505	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS545_RS05525	COG0789	Transcriptional regulator
CS545_RS05540	COG0720	synthase
CS545_RS05545	COG0602	queuosine metabolic process
CS545_RS05560	COG1556	Lactate utilization protein
CS545_RS05565	COG1139	Iron-sulfur cluster binding protein
CS545_RS05570	COG0247	lactate metabolic process
CS545_RS05575	COG0560	Phosphoserine phosphatase
CS545_RS05600	COG2096	Adenosyltransferase
CS545_RS05605	COG1492	cobalamin metabolic process
CS545_RS05615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CS545_RS05620	COG1187	pseudouridine synthase activity
CS545_RS05640	COG1979	alcohol dehydrogenase
CS545_RS05660	COG1022	Amp-dependent synthetase and ligase
CS545_RS05685	COG0438	transferase activity, transferring glycosyl groups
CS545_RS05720	COG0492	ferredoxin-NADP+ reductase activity
CS545_RS05735	COG0525	valine-tRNA ligase activity
CS545_RS05755	COG1570	exodeoxyribonuclease VII activity
CS545_RS05760	COG1522	sequence-specific DNA binding
CS545_RS05765	COG2233	PERMEase
CS545_RS05775	COG2096	Adenosyltransferase
CS545_RS05785	COG1187	pseudouridine synthase activity
CS545_RS05790	COG0017	Asparaginyl-tRNA synthetase
CS545_RS05805	COG0542	response to heat
CS545_RS05810	COG0534	Mate efflux family protein
CS545_RS05815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CS545_RS05820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CS545_RS05825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CS545_RS05830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS545_RS05835	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS545_RS05840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CS545_RS05845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CS545_RS05855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS545_RS05865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CS545_RS05885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS545_RS05900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS545_RS05905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS545_RS05940	COG1242	4 iron, 4 sulfur cluster binding
CS545_RS05950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS545_RS05960	COG0280	phosphate acetyltransferase
CS545_RS05965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CS545_RS05975	COG1024	Enoyl-CoA hydratase
CS545_RS05980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS545_RS05985	COG2086	electron transfer activity
CS545_RS05990	COG1960	acyl-CoA dehydrogenase activity
CS545_RS06000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS545_RS06005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CS545_RS06025	COG0604	alcohol dehydrogenase
CS545_RS06030	COG3246	L-lysine catabolic process to acetate
CS545_RS06035	COG1607	acyl-coa hydrolase
CS545_RS06045	COG0167	dihydroorotate dehydrogenase activity
CS545_RS06050	COG0543	2 iron, 2 sulfur cluster binding
CS545_RS06060	COG5433	transposase activity
CS545_RS06065	COG0793	Belongs to the peptidase S41A family
CS545_RS06080	COG1132	(ABC) transporter
CS545_RS06110	COG1696	Membrane protein involved in D-alanine export
CS545_RS06210	COG0443	Heat shock 70 kDa protein
CS545_RS06240	COG0328	RNA-DNA hybrid ribonuclease activity
CS545_RS06240	COG3341	Caulimovirus viroplasmin
CS545_RS06270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS545_RS06290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CS545_RS06295	COG0488	(ABC) transporter
CS545_RS06300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CS545_RS06315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS545_RS06330	COG2197	response regulator
CS545_RS06335	COG0564	pseudouridine synthase activity
CS545_RS06345	COG1309	transcriptional regulator
CS545_RS06355	COG0481	GTPase activity
CS545_RS06360	COG0305	Participates in initiation and elongation during chromosome replication
CS545_RS06375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CS545_RS06380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CS545_RS06385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CS545_RS06600	COG0358	DNA primase activity
CS545_RS06670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CS545_RS06680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CS545_RS06685	COG1530	ribonuclease E activity
CS545_RS06695	COG0602	queuosine metabolic process
CS545_RS06700	COG1328	CTP reductase activity
CS545_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
CS545_RS06770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS545_RS06780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS545_RS06795	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS545_RS06800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CS545_RS06815	COG1193	negative regulation of DNA recombination
CS545_RS06825	COG3591	Belongs to the peptidase S1B family
CS545_RS06830	COG0363	glucosamine-6-phosphate deaminase activity
CS545_RS06840	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CS545_RS06845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS545_RS06850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS545_RS06860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS545_RS06860	COG1918	ferrous iron import across plasma membrane
CS545_RS06905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CS545_RS06905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CS545_RS06910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS545_RS06915	COG0357	Ribosomal RNA small subunit methyltransferase G
CS545_RS06930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CS545_RS06970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CS545_RS06975	COG1047	Peptidyl-prolyl cis-trans
CS545_RS07005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CS545_RS07010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CS545_RS07015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CS545_RS07025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS07025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS07045	COG1970	mechanosensitive ion channel activity
CS545_RS07060	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CS545_RS07095	COG1620	l-lactate permease
CS545_RS07105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CS545_RS07110	COG0321	lipoyl(octanoyl) transferase activity
CS545_RS07110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS545_RS07120	COG0438	transferase activity, transferring glycosyl groups
CS545_RS07125	COG0582	viral genome integration into host DNA
CS545_RS07165	COG0551	DNA topoisomerase type I activity
CS545_RS07165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS545_RS07175	COG0156	8-amino-7-oxononanoate synthase activity
CS545_RS07185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CS545_RS07320	COG0358	DNA primase activity
CS545_RS07405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CS545_RS07410	COG1597	lipid kinase activity
CS545_RS07425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CS545_RS07430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS545_RS07490	COG0823	Involved in the tonB-independent uptake of proteins
CS545_RS07490	COG1506	peptidase
CS545_RS07495	COG0116	Belongs to the methyltransferase superfamily
CS545_RS07505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CS545_RS07510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CS545_RS07515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CS545_RS07525	COG0166	Belongs to the GPI family
CS545_RS07535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CS545_RS07540	COG0813	purine-nucleoside phosphorylase activity
CS545_RS07555	COG1194	a g-specific adenine glycosylase
CS545_RS07560	COG1116	anion transmembrane transporter activity
CS545_RS07560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS545_RS07585	COG3421	Type III restriction
CS545_RS07590	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CS545_RS07600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS545_RS07640	COG0772	Belongs to the SEDS family
CS545_RS07645	COG0768	penicillin binding
CS545_RS07665	COG0138	bifunctional purine biosynthesis protein purh
CS545_RS07695	COG3033	Beta-eliminating lyase
CS545_RS07740	COG0569	domain protein
CS545_RS07740	COG2985	domain, Protein
CS545_RS07780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CS545_RS07790	COG2027	D-alanyl-D-alanine carboxypeptidase
CS545_RS07800	COG2957	Belongs to the agmatine deiminase family
CS545_RS07825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CS545_RS07835	COG2197	response regulator
CS545_RS07840	COG2205	protein histidine kinase activity
CS545_RS07840	COG5002	protein histidine kinase activity
CS545_RS07840	COG0784	Response regulator, receiver
CS545_RS07850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CS545_RS07870	COG1968	undecaprenyl-diphosphatase activity
CS545_RS07875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CS545_RS07880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CS545_RS07885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CS545_RS07890	COG0826	peptidase U32
CS545_RS07900	COG3022	response to hydroperoxide
CS545_RS07905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS545_RS07935	COG4771	TonB-dependent receptor
CS545_RS07940	COG1429	ligase activity, forming nitrogen-metal bonds
CS545_RS07960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CS545_RS07995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS545_RS08015	COG0730	response to heat
CS545_RS08020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS545_RS08025	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CS545_RS08030	COG1518	maintenance of DNA repeat elements
CS545_RS08040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CS545_RS08050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CS545_RS08055	COG0714	Associated with various cellular activities
CS545_RS08095	COG0671	phosphoesterase, PA-phosphatase related
CS545_RS08100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS545_RS08105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CS545_RS08115	COG1480	7TM receptor with intracellular HD hydrolase
CS545_RS08120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS545_RS08130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CS545_RS08150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CS545_RS08155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS545_RS08160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CS545_RS08175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CS545_RS08175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CS545_RS08185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CS545_RS08240	COG0511	ligase activity, forming carbon-carbon bonds
CS545_RS08255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS545_RS08260	COG0346	lactoylglutathione lyase activity
CS545_RS08270	COG1053	succinate dehydrogenase
CS545_RS08290	COG2217	Heavy metal translocating P-type atpase
CS545_RS08295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS545_RS08300	COG0534	Mate efflux family protein
CS545_RS08305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS545_RS08310	COG1674	ftsk spoiiie
CS545_RS08325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CS545_RS08390	COG0500	methyltransferase
CS545_RS08395	COG2830	Protein of unknown function (DUF452)
CS545_RS08400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS545_RS08425	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CS545_RS08440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS545_RS08445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS545_RS08445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS545_RS08475	COG1136	(ABC) transporter
CS545_RS08480	COG0577	efflux transmembrane transporter activity
CS545_RS08480	COG1136	(ABC) transporter
CS545_RS08485	COG1136	(ABC) transporter
CS545_RS08485	COG0577	efflux transmembrane transporter activity
CS545_RS08550	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CS545_RS08555	COG0126	phosphoglycerate kinase activity
CS545_RS08565	COG1131	(ABC) transporter
CS545_RS08575	COG0438	transferase activity, transferring glycosyl groups
CS545_RS08610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CS545_RS08625	COG1136	(ABC) transporter
CS545_RS08630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CS545_RS08635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS545_RS08650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CS545_RS08655	COG0187	DNA topoisomerase II activity
CS545_RS08660	COG3956	TIGRFAM MazG family protein
CS545_RS08670	COG0564	pseudouridine synthase activity
CS545_RS08710	COG0259	pyridoxamine-phosphate oxidase activity
CS545_RS08730	COG1132	(ABC) transporter
CS545_RS08740	COG0557	exoribonuclease II activity
CS545_RS08755	COG0268	Binds directly to 16S ribosomal RNA
CS545_RS08765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CS545_RS08770	COG1546	Belongs to the CinA family
CS545_RS08770	COG1058	Belongs to the CinA family
CS545_RS08785	COG0590	tRNA wobble adenosine to inosine editing
CS545_RS08790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CS545_RS08800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CS545_RS08805	COG4974	Belongs to the 'phage' integrase family
CS545_RS08825	COG1940	carbohydrate kinase activity
CS545_RS08835	COG0248	Ppx GppA phosphatase
CS545_RS08840	COG1027	Aspartate ammonia-lyase
CS545_RS08845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CS545_RS08875	COG1253	flavin adenine dinucleotide binding
CS545_RS08880	COG0629	single-stranded DNA binding
CS545_RS08885	COG0583	DNA-binding transcription factor activity
CS545_RS08890	COG0708	Exodeoxyribonuclease III
CS545_RS08895	COG0482	sulfurtransferase activity
CS545_RS08900	COG0018	arginyl-trna synthetase
CS545_RS08910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CS545_RS08920	COG0719	Fe-S assembly protein
CS545_RS08925	COG0396	ATPase activity
CS545_RS08930	COG0719	Fe-S assembly protein
CS545_RS08940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CS545_RS08940	COG3266	domain, Protein
CS545_RS08945	COG0195	Participates in both transcription termination and antitermination
CS545_RS08950	COG0779	Required for maturation of 30S ribosomal subunits
CS545_RS08990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS545_RS09000	COG1011	Hydrolase
CS545_RS09005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CS545_RS09030	COG3876	Protein conserved in bacteria
CS545_RS09035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS545_RS09050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CS545_RS09060	COG2095	MarC family integral membrane protein
CS545_RS09145	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CS545_RS09150	COG2116	formate transmembrane transporter activity
CS545_RS09160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CS545_RS09180	COG0594	ribonuclease P activity
CS545_RS09185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CS545_RS09190	COG0084	hydrolase, TatD family'
CS545_RS09195	COG3152	Membrane
CS545_RS09205	COG0612	Peptidase, M16
CS545_RS09215	COG1592	Rubrerythrin
CS545_RS09225	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CS545_RS09235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CS545_RS09250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS545_RS09260	COG1629	transport
CS545_RS09290	COG0446	pyridine nucleotide-disulphide oxidoreductase
CS545_RS09305	COG0737	Belongs to the 5'-nucleotidase family
CS545_RS09310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS545_RS09310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS545_RS09320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CS545_RS09325	COG0193	aminoacyl-tRNA hydrolase activity
CS545_RS09330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CS545_RS09355	COG3590	peptidase
CS545_RS09360	COG1040	competence protein
CS545_RS09365	COG2137	regulation of response to DNA damage stimulus
CS545_RS09370	COG2890	protein-(glutamine-N5) methyltransferase activity
CS545_RS09375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS545_RS09375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS545_RS09380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CS545_RS09390	COG0552	protein localization to endoplasmic reticulum
CS545_RS09395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS545_RS09425	COG2957	Belongs to the agmatine deiminase family
CS545_RS09435	COG1192	Involved in chromosome partitioning
CS545_RS09440	COG1475	DNA binding
CS545_RS09450	COG1388	LysM domain
CS545_RS09450	COG3942	CHAP domain
CS545_RS09455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CS545_RS09460	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS545_RS09470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CS545_RS09475	COG2239	Acts as a magnesium transporter
CS545_RS09495	COG0588	phosphoglycerate mutase activity
CS545_RS09500	COG0438	transferase activity, transferring glycosyl groups
CS545_RS09510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CS545_RS09525	COG1739	Uncharacterized protein family UPF0029
CS545_RS09535	COG0776	regulation of translation
CS545_RS09580	COG0297	glycogen (starch) synthase activity
CS545_RS09580	COG0438	transferase activity, transferring glycosyl groups
CS545_RS09605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS545_RS09610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS545_RS09620	COG0551	DNA topoisomerase type I activity
CS545_RS09620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS545_RS09690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS545_RS09695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CS545_RS09700	COG3104	oligopeptide transport
CS545_RS09715	COG0180	Tryptophanyl-tRNA synthetase
CS545_RS09725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CS545_RS09770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CS545_RS09775	COG0513	Belongs to the DEAD box helicase family
CS545_RS09815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CS545_RS09820	COG2022	thiamine diphosphate biosynthetic process
CS545_RS09825	COG0352	thiamine-phosphate diphosphorylase activity
CS545_RS09830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CS545_RS09870	COG0228	four-way junction DNA binding
CS545_RS09885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS545_RS09890	COG0252	asparaginase activity
CS545_RS09910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CS545_RS09970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CS545_RS09975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS545_RS09980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CS545_RS09985	COG1160	GTP binding
CS545_RS09995	COG0726	polysaccharide deacetylase
CS545_RS10000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS545_RS10000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CS545_RS10005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS545_RS10010	COG2233	PERMEase
CS545_RS10050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS545_RS10060	COG2166	iron-sulfur cluster assembly
CS545_RS10065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CS545_RS10075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS545_RS10080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CS545_RS10090	COG0423	glycine-tRNA ligase activity
CS545_RS10115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS545_RS10150	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS545_RS10155	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS545_RS10160	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS545_RS10170	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS545_RS10230	COG1575	Belongs to the MenA family. Type 1 subfamily
CS545_RS10235	COG0019	diaminopimelate decarboxylase activity
CS545_RS10240	COG0527	aspartate kinase activity
CS545_RS10245	COG2884	Cell division ATP-binding protein ftsE
CS545_RS10250	COG0739	heme binding
CS545_RS10255	COG0012	GTP binding
CS545_RS10260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS545_RS10265	COG4589	Belongs to the CDS family
CS545_RS10270	COG0326	Molecular chaperone. Has ATPase activity
CS545_RS10275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CS545_RS10280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CS545_RS10290	COG0335	large ribosomal subunit rRNA binding
CS545_RS10300	COG3118	belongs to the thioredoxin family
CS545_RS10325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CS545_RS10355	COG0295	cytidine deaminase activity
CS545_RS10370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CS545_RS10385	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS545_RS10390	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CS545_RS10395	COG0659	secondary active sulfate transmembrane transporter activity
CS545_RS10430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS545_RS10435	COG1472	Belongs to the glycosyl hydrolase 3 family
CS545_RS10440	COG0542	response to heat
CS545_RS10465	COG1408	metallophosphoesterase
CS545_RS10470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CS545_RS10485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CS545_RS10525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS545_RS10550	COG0569	domain protein
CS545_RS10555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CS545_RS10620	COG0488	(ABC) transporter
CS545_RS10625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS545_RS10640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CS545_RS10645	COG0242	peptide deformylase activity
CS545_RS10655	COG0488	(ABC) transporter
CS545_RS10660	COG2957	Belongs to the agmatine deiminase family
CS545_RS10670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CS545_RS10675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS545_RS10680	COG0124	histidyl-tRNA synthetase
CS545_RS10705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CS545_RS10715	COG0300	oxidoreductase activity