locus-tag	class	description
CUB95_RS00010	COG0318	PFAM AMP-dependent synthetase and ligase
CUB95_RS00015	COG4591	ABC-type transport system involved in lipoprotein release permease component
CUB95_RS00040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CUB95_RS00045	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CUB95_RS00050	COG0519	Catalyzes the synthesis of GMP from XMP
CUB95_RS00065	COG1215	transferase activity, transferring glycosyl groups
CUB95_RS00105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CUB95_RS00125	COG0513	Belongs to the DEAD box helicase family
CUB95_RS00130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CUB95_RS00135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUB95_RS00145	COG1739	Uncharacterized protein family UPF0029
CUB95_RS00165	COG4206	TonB-dependent receptor
CUB95_RS00185	COG0628	permease
CUB95_RS00195	COG1482	cell wall glycoprotein biosynthetic process
CUB95_RS00200	COG0513	Belongs to the DEAD box helicase family
CUB95_RS00210	COG0222	ribosome binding
CUB95_RS00235	COG0612	Peptidase, M16
CUB95_RS00240	COG0470	DNA polymerase III
CUB95_RS00245	COG1774	PSP1 C-terminal conserved region
CUB95_RS00255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUB95_RS00290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CUB95_RS00300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CUB95_RS00315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CUB95_RS00330	COG0737	Belongs to the 5'-nucleotidase family
CUB95_RS00335	COG2816	NAD+ diphosphatase activity
CUB95_RS00340	COG2252	PERMEase
CUB95_RS00350	COG0471	metal ion transport
CUB95_RS00360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUB95_RS00365	COG2233	PERMEase
CUB95_RS00380	COG0463	Glycosyl transferase, family 2
CUB95_RS00385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUB95_RS00390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUB95_RS00445	COG1047	Peptidyl-prolyl cis-trans
CUB95_RS00450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CUB95_RS00455	COG0167	dihydroorotate dehydrogenase activity
CUB95_RS00460	COG0543	2 iron, 2 sulfur cluster binding
CUB95_RS00485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CUB95_RS00490	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUB95_RS00495	COG0475	glutathione-regulated potassium exporter activity
CUB95_RS00525	COG0569	domain protein
CUB95_RS00525	COG2985	domain, Protein
CUB95_RS00535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CUB95_RS00540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUB95_RS00555	COG0071	Belongs to the small heat shock protein (HSP20) family
CUB95_RS00565	COG0237	dephospho-CoA kinase activity
CUB95_RS00575	COG1862	Preprotein translocase
CUB95_RS00580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUB95_RS00585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CUB95_RS00590	COG0193	aminoacyl-tRNA hydrolase activity
CUB95_RS00610	COG2027	D-alanyl-D-alanine carboxypeptidase
CUB95_RS00615	COG0668	transmembrane transport
CUB95_RS00640	COG1960	acyl-CoA dehydrogenase activity
CUB95_RS00650	COG2086	electron transfer activity
CUB95_RS00655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUB95_RS00660	COG0166	Belongs to the GPI family
CUB95_RS00665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUB95_RS00670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CUB95_RS00685	COG2050	protein possibly involved in aromatic compounds catabolism
CUB95_RS00690	COG1169	isochorismate synthase
CUB95_RS00695	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CUB95_RS00700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CUB95_RS00705	COG4948	Mandelate Racemase Muconate Lactonizing
CUB95_RS00715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUB95_RS00730	COG0138	bifunctional purine biosynthesis protein purh
CUB95_RS00860	COG2369	cell adhesion
CUB95_RS00950	COG3392	D12 class N6 adenine-specific DNA methyltransferase
CUB95_RS00955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CUB95_RS00965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUB95_RS00985	COG1187	pseudouridine synthase activity
CUB95_RS00995	COG0515	serine threonine protein kinase
CUB95_RS00995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CUB95_RS01010	COG0632	four-way junction helicase activity
CUB95_RS01020	COG0742	ribosomal rna small subunit methyltransferase
CUB95_RS01050	COG0482	sulfurtransferase activity
CUB95_RS01055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CUB95_RS01060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CUB95_RS01065	COG0126	phosphoglycerate kinase activity
CUB95_RS01075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CUB95_RS01120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CUB95_RS01135	COG2382	esterase
CUB95_RS01140	COG0191	fructose-bisphosphate aldolase activity
CUB95_RS01145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CUB95_RS01145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CUB95_RS01150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CUB95_RS01155	COG0563	adenylate kinase activity
CUB95_RS01160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CUB95_RS01165	COG1496	oxidoreductase activity
CUB95_RS01175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CUB95_RS01185	COG0842	Transport permease protein
CUB95_RS01190	COG1131	(ABC) transporter
CUB95_RS01205	COG2207	Transcriptional regulator
CUB95_RS01210	COG0673	inositol 2-dehydrogenase activity
CUB95_RS01220	COG0335	large ribosomal subunit rRNA binding
CUB95_RS01230	COG0737	Belongs to the 5'-nucleotidase family
CUB95_RS01250	COG2184	nucleotidyltransferase activity
CUB95_RS01255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CUB95_RS01315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CUB95_RS01345	COG3645	SOS response
CUB95_RS01355	COG0358	DNA primase activity
CUB95_RS01360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUB95_RS01370	COG0203	ribosomal protein L17
CUB95_RS01375	COG0202	RNA polymerase activity
CUB95_RS01380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CUB95_RS01385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CUB95_RS01390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CUB95_RS01395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CUB95_RS01400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CUB95_RS01405	COG0201	protein transport
CUB95_RS01410	COG0200	Binds to the 23S rRNA
CUB95_RS01415	COG1841	ribosomal large subunit assembly
CUB95_RS01420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CUB95_RS01425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CUB95_RS01430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CUB95_RS01435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CUB95_RS01440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CUB95_RS01445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CUB95_RS01450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CUB95_RS01455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CUB95_RS01460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CUB95_RS01465	COG0255	Belongs to the universal ribosomal protein uL29 family
CUB95_RS01470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CUB95_RS01475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CUB95_RS01485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CUB95_RS01490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CUB95_RS01495	COG0089	rRNA binding
CUB95_RS01500	COG0088	Forms part of the polypeptide exit tunnel
CUB95_RS01505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CUB95_RS01510	COG0051	transcription antitermination factor activity, RNA binding
CUB95_RS01515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUB95_RS01520	COG0049	tRNA binding
CUB95_RS01525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CUB95_RS01745	COG3392	D12 class N6 adenine-specific DNA methyltransferase
CUB95_RS01775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CUB95_RS01780	COG0085	RNA polymerase activity
CUB95_RS01785	COG0222	ribosome binding
CUB95_RS01790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CUB95_RS01795	COG0081	regulation of translation
CUB95_RS01800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CUB95_RS01820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUB95_RS01850	COG4974	Belongs to the 'phage' integrase family
CUB95_RS01855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CUB95_RS01900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CUB95_RS01920	COG0039	L-malate dehydrogenase activity
CUB95_RS01950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CUB95_RS01955	COG1480	7TM receptor with intracellular HD hydrolase
CUB95_RS01965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB95_RS01995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUB95_RS02045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CUB95_RS02060	COG2096	Adenosyltransferase
CUB95_RS02135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CUB95_RS02140	COG0426	domain, Protein
CUB95_RS02145	COG0612	Peptidase, M16
CUB95_RS02250	COG4974	Belongs to the 'phage' integrase family
CUB95_RS02255	COG0582	viral genome integration into host DNA
CUB95_RS02290	COG0756	dUTP diphosphatase activity
CUB95_RS02305	COG2255	four-way junction helicase activity
CUB95_RS02315	COG0280	phosphate acetyltransferase
CUB95_RS02320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CUB95_RS02325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB95_RS02330	COG0156	8-amino-7-oxononanoate synthase activity
CUB95_RS02350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CUB95_RS02360	COG0351	phosphomethylpyrimidine kinase
CUB95_RS02360	COG0352	thiamine-phosphate diphosphorylase activity
CUB95_RS02395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CUB95_RS02395	COG0674	pyruvate-flavodoxin oxidoreductase activity
CUB95_RS02400	COG1013	pyruvate-flavodoxin oxidoreductase activity
CUB95_RS02405	COG0045	succinate-CoA ligase (ADP-forming) activity
CUB95_RS02410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CUB95_RS02420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB95_RS02420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUB95_RS02495	COG4974	Belongs to the 'phage' integrase family
CUB95_RS02565	COG0537	adenosine 5'-monophosphoramidase activity
CUB95_RS02570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CUB95_RS02575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUB95_RS02650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CUB95_RS02675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CUB95_RS02680	COG3341	Caulimovirus viroplasmin
CUB95_RS02680	COG0328	RNA-DNA hybrid ribonuclease activity
CUB95_RS02690	COG0018	arginyl-trna synthetase
CUB95_RS02695	COG1120	ATPase activity
CUB95_RS02705	COG1620	l-lactate permease
CUB95_RS02710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB95_RS02715	COG1132	(ABC) transporter
CUB95_RS02740	COG3475	LICD family
CUB95_RS02750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CUB95_RS02775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUB95_RS02775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUB95_RS02780	COG2890	protein-(glutamine-N5) methyltransferase activity
CUB95_RS02800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CUB95_RS02815	COG0594	ribonuclease P activity
CUB95_RS02820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CUB95_RS02825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CUB95_RS02850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUB95_RS02855	COG1283	sodium-dependent phosphate transmembrane transporter activity
CUB95_RS02860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CUB95_RS02865	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CUB95_RS02875	COG1438	arginine binding
CUB95_RS02880	COG1131	(ABC) transporter
CUB95_RS02900	COG3590	peptidase
CUB95_RS02910	COG1022	Amp-dependent synthetase and ligase
CUB95_RS02915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CUB95_RS02920	COG2954	triphosphatase activity
CUB95_RS02960	COG3681	Belongs to the UPF0597 family
CUB95_RS02965	COG0351	phosphomethylpyrimidine kinase
CUB95_RS02970	COG0352	thiamine-phosphate diphosphorylase activity
CUB95_RS02975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CUB95_RS02980	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CUB95_RS02985	COG0352	thiamine-phosphate diphosphorylase activity
CUB95_RS02995	COG3610	response to peptide
CUB95_RS03000	COG0583	DNA-binding transcription factor activity
CUB95_RS03015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CUB95_RS03020	COG0545	Peptidyl-prolyl cis-trans isomerase
CUB95_RS03035	COG1522	sequence-specific DNA binding
CUB95_RS03045	COG2234	aminopeptidase activity
CUB95_RS03055	COG3279	Response regulator of the LytR AlgR family
CUB95_RS03060	COG3275	phosphorelay sensor kinase activity
CUB95_RS03070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CUB95_RS03110	COG0606	chelatase, subunit chli
CUB95_RS03150	COG0557	exoribonuclease II activity
CUB95_RS03160	COG0564	pseudouridine synthase activity
CUB95_RS03205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CUB95_RS03210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CUB95_RS03220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CUB95_RS03255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CUB95_RS03275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CUB95_RS03280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CUB95_RS03285	COG0495	leucyl-tRNA aminoacylation
CUB95_RS03305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUB95_RS03310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CUB95_RS03315	COG0571	ribonuclease III activity
CUB95_RS03320	COG0012	GTP binding
CUB95_RS03325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CUB95_RS03335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUB95_RS03345	COG0393	Putative heavy-metal-binding
CUB95_RS03350	COG0215	cysteine-tRNA ligase activity
CUB95_RS03355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CUB95_RS03365	COG2166	iron-sulfur cluster assembly
CUB95_RS03375	COG0826	peptidase U32
CUB95_RS03380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUB95_RS03380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUB95_RS03395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CUB95_RS03400	COG1694	Mazg nucleotide pyrophosphohydrolase
CUB95_RS03405	COG1490	D-aminoacyl-tRNA deacylase activity
CUB95_RS03410	COG0322	excinuclease ABC activity
CUB95_RS03415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CUB95_RS03420	COG0445	tRNA wobble uridine modification
CUB95_RS03430	COG1053	succinate dehydrogenase
CUB95_RS03435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CUB95_RS03445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CUB95_RS03450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CUB95_RS03520	COG0534	Mate efflux family protein
CUB95_RS03540	COG0693	protein deglycase activity
CUB95_RS03600	COG1132	(ABC) transporter
CUB95_RS03675	COG0793	Belongs to the peptidase S41A family
CUB95_RS03675	COG3409	Peptidoglycan-binding domain 1 protein
CUB95_RS03695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CUB95_RS03705	COG0622	Phosphoesterase
CUB95_RS03715	COG0758	DNA mediated transformation
CUB95_RS03730	COG0671	phosphoesterase, PA-phosphatase related
CUB95_RS03735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUB95_RS03765	COG0196	riboflavin kinase activity
CUB95_RS03825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUB95_RS03830	COG1185	polyribonucleotide nucleotidyltransferase activity
CUB95_RS03835	COG2217	Heavy metal translocating P-type atpase
CUB95_RS03845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CUB95_RS03850	COG2255	four-way junction helicase activity
CUB95_RS03885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CUB95_RS03890	COG1166	arginine decarboxylase activity
CUB95_RS03910	COG2003	Belongs to the UPF0758 family
CUB95_RS03915	COG1216	Glycosyl transferase, family 2
CUB95_RS03920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CUB95_RS03925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CUB95_RS03935	COG0564	pseudouridine synthase activity
CUB95_RS03940	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUB95_RS03960	COG4591	ABC-type transport system involved in lipoprotein release permease component
CUB95_RS03965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CUB95_RS03970	COG1162	GTPase activity
CUB95_RS03980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUB95_RS03985	COG0569	domain protein
CUB95_RS03990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CUB95_RS04005	COG0670	Belongs to the BI1 family
CUB95_RS04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUB95_RS04090	COG2755	lipolytic protein G-D-S-L family
CUB95_RS04090	COG0657	acetylesterase activity
CUB95_RS04135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CUB95_RS04140	COG0779	Required for maturation of 30S ribosomal subunits
CUB95_RS04145	COG0195	Participates in both transcription termination and antitermination
CUB95_RS04150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CUB95_RS04155	COG0719	Fe-S assembly protein
CUB95_RS04165	COG0396	ATPase activity
CUB95_RS04170	COG0719	Fe-S assembly protein
CUB95_RS04175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CUB95_RS04190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CUB95_RS04200	COG4771	TonB-dependent receptor
CUB95_RS04220	COG1404	Belongs to the peptidase S8 family
CUB95_RS04240	COG0793	Belongs to the peptidase S41A family
CUB95_RS04255	COG0058	SHG alpha-glucan phosphorylase activity
CUB95_RS04290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CUB95_RS04295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CUB95_RS04300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CUB95_RS04315	COG1595	DNA-templated transcription, initiation
CUB95_RS04325	COG1381	Involved in DNA repair and RecF pathway recombination
CUB95_RS04335	COG0268	Binds directly to 16S ribosomal RNA
CUB95_RS04345	COG0187	DNA topoisomerase II activity
CUB95_RS04355	COG0612	Peptidase, M16
CUB95_RS04380	COG2001	Belongs to the MraZ family
CUB95_RS04385	COG0275	rRNA processing
CUB95_RS04395	COG0768	penicillin binding
CUB95_RS04400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUB95_RS04405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUB95_RS04410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUB95_RS04415	COG0772	Belongs to the SEDS family
CUB95_RS04420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUB95_RS04425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUB95_RS04440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CUB95_RS04465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CUB95_RS04470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CUB95_RS04500	COG1216	Glycosyl transferase, family 2
CUB95_RS04505	COG0438	transferase activity, transferring glycosyl groups
CUB95_RS04515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CUB95_RS04560	COG0194	GDP metabolic process
CUB95_RS04565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CUB95_RS04575	COG1216	Glycosyl transferase, family 2
CUB95_RS04595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CUB95_RS04620	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CUB95_RS04630	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CUB95_RS04660	COG0252	asparaginase activity
CUB95_RS04665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CUB95_RS04670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CUB95_RS04690	COG0739	heme binding
CUB95_RS04695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CUB95_RS04700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CUB95_RS04710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CUB95_RS04715	COG1132	(ABC) transporter
CUB95_RS04755	COG2211	Major facilitator Superfamily
CUB95_RS04765	COG1629	transport
CUB95_RS04765	COG4206	TonB-dependent receptor
CUB95_RS04770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CUB95_RS04800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CUB95_RS04805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CUB95_RS04810	COG0052	Belongs to the universal ribosomal protein uS2 family
CUB95_RS04815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CUB95_RS04825	COG0179	Fumarylacetoacetate (FAA) hydrolase
CUB95_RS04840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CUB95_RS04870	COG3475	LICD family
CUB95_RS04875	COG0750	zinc metalloprotease
CUB95_RS04880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CUB95_RS04885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CUB95_RS04890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUB95_RS04900	COG1214	PFAM Peptidase M22, glycoprotease
CUB95_RS04915	COG0366	Alpha amylase catalytic
CUB95_RS04920	COG1523	belongs to the glycosyl hydrolase 13 family
CUB95_RS04925	COG1082	Xylose isomerase domain protein TIM barrel
CUB95_RS04930	COG1640	4-alpha-glucanotransferase
CUB95_RS04935	COG2081	HI0933 family
CUB95_RS04950	COG1621	beta-fructofuranosidase activity
CUB95_RS04960	COG0745	RESPONSE REGULATOR receiver
CUB95_RS04960	COG2205	protein histidine kinase activity
CUB95_RS04960	COG3292	Two component regulator propeller
CUB95_RS04990	COG2033	superoxide reductase activity
CUB95_RS05035	COG0659	secondary active sulfate transmembrane transporter activity
CUB95_RS05050	COG1388	LysM domain
CUB95_RS05050	COG0741	lytic transglycosylase activity
CUB95_RS05060	COG1475	DNA binding
CUB95_RS05065	COG1192	Involved in chromosome partitioning
CUB95_RS05070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CUB95_RS05075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB95_RS05080	COG0586	Pfam SNARE associated Golgi protein
CUB95_RS05095	COG0423	glycine-tRNA ligase activity
CUB95_RS05115	COG0793	Belongs to the peptidase S41A family
CUB95_RS05125	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CUB95_RS05130	COG0544	peptidyl-prolyl cis-trans isomerase activity
CUB95_RS05135	COG0740	serine-type endopeptidase activity
CUB95_RS05140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CUB95_RS05145	COG0514	ATP-dependent DNA helicase (RecQ)
CUB95_RS05160	COG0517	IMP dehydrogenase activity
CUB95_RS05160	COG0516	GMP reductase activity
CUB95_RS05165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUB95_RS05185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUB95_RS05200	COG0488	(ABC) transporter
CUB95_RS05205	COG1137	ATPase activity
CUB95_RS05210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CUB95_RS05215	COG1127	ABC transporter
CUB95_RS05225	COG1160	GTP binding
CUB95_RS05230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CUB95_RS05235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUB95_RS05255	COG4191	Histidine kinase
CUB95_RS05290	COG0582	viral genome integration into host DNA
CUB95_RS05310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CUB95_RS05365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUB95_RS05380	COG1162	GTPase activity
CUB95_RS05385	COG0233	cytoplasmic translational termination
CUB95_RS05390	COG1956	GAF domain-containing protein
CUB95_RS05395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CUB95_RS05405	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUB95_RS05410	COG0598	Magnesium transport protein CorA
CUB95_RS05435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CUB95_RS05445	COG4771	TonB-dependent receptor
CUB95_RS05495	COG3279	Response regulator of the LytR AlgR family
CUB95_RS05500	COG4659	FMN binding
CUB95_RS05505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CUB95_RS05510	COG0589	response to stress
CUB95_RS05510	COG0475	glutathione-regulated potassium exporter activity
CUB95_RS05515	COG1136	(ABC) transporter
CUB95_RS05520	COG2996	Protein conserved in bacteria
CUB95_RS05555	COG1397	ADP-ribosylglycohydrolase
CUB95_RS05580	COG0848	biopolymer transport protein
CUB95_RS05590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUB95_RS05605	COG1733	regulation of RNA biosynthetic process
CUB95_RS05635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CUB95_RS05650	COG0138	bifunctional purine biosynthesis protein purh
CUB95_RS05670	COG0768	penicillin binding
CUB95_RS05675	COG0772	Belongs to the SEDS family
CUB95_RS05685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUB95_RS05705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUB95_RS05735	COG2885	chlorophyll binding
CUB95_RS05760	COG4232	protein-disulfide reductase activity
CUB95_RS05765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CUB95_RS05780	COG0792	nuclease activity
CUB95_RS05785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CUB95_RS05785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CUB95_RS05790	COG0528	UMP kinase activity
CUB95_RS05795	COG0802	atpase or kinase
CUB95_RS05800	COG0745	RESPONSE REGULATOR receiver
CUB95_RS05815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CUB95_RS05835	COG1183	phosphatidylcholine synthase activity
CUB95_RS05840	COG0688	phosphatidylethanolamine metabolic process
CUB95_RS05860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB95_RS05865	COG1538	Outer membrane efflux protein
CUB95_RS05905	COG1968	undecaprenyl-diphosphatase activity
CUB95_RS05910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CUB95_RS05915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUB95_RS05945	COG0783	Belongs to the Dps family
CUB95_RS05955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CUB95_RS05960	COG1217	gtp-binding protein TYPA
CUB95_RS05980	COG1854	S-ribosylhomocysteine lyase activity
CUB95_RS05985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CUB95_RS06010	COG0149	triose-phosphate isomerase activity
CUB95_RS06020	COG0302	gtp cyclohydrolase
CUB95_RS06025	COG0708	Exodeoxyribonuclease III
CUB95_RS06035	COG1696	Membrane protein involved in D-alanine export
CUB95_RS06055	COG2233	PERMEase
CUB95_RS06060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CUB95_RS06175	COG0454	-acetyltransferase
CUB95_RS06200	COG0358	DNA primase activity
CUB95_RS06200	COG0305	Participates in initiation and elongation during chromosome replication
CUB95_RS06340	COG2274	protein secretion by the type I secretion system
CUB95_RS06360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUB95_RS06365	COG1309	transcriptional regulator
CUB95_RS06375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CUB95_RS06375	COG0551	DNA topoisomerase type I activity
CUB95_RS06425	COG0582	viral genome integration into host DNA
CUB95_RS06450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUB95_RS06480	COG4974	Belongs to the 'phage' integrase family
CUB95_RS06485	COG0582	viral genome integration into host DNA
CUB95_RS06525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CUB95_RS06535	COG0612	Peptidase, M16
CUB95_RS06540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CUB95_RS06540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CUB95_RS06555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CUB95_RS06560	COG1388	LysM domain
CUB95_RS06560	COG0860	N-Acetylmuramoyl-L-alanine amidase
CUB95_RS06580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CUB95_RS06610	COG1720	tRNA m6t6A37 methyltransferase activity
CUB95_RS06620	COG0542	response to heat
CUB95_RS06650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CUB95_RS06665	COG1404	Belongs to the peptidase S8 family
CUB95_RS06665	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CUB95_RS06670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CUB95_RS06675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CUB95_RS06680	COG0157	Belongs to the NadC ModD family
CUB95_RS06685	COG0716	FMN binding
CUB95_RS06735	COG2217	Heavy metal translocating P-type atpase
CUB95_RS06740	COG2217	Heavy metal translocating P-type atpase
CUB95_RS06745	COG1418	mRNA catabolic process
CUB95_RS06765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CUB95_RS06770	COG0489	protein tyrosine kinase activity
CUB95_RS06790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CUB95_RS06805	COG1228	amidohydrolase
CUB95_RS06810	COG2986	histidine ammonia-lyase
CUB95_RS06815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CUB95_RS06825	COG2017	converts alpha-aldose to the beta-anomer
CUB95_RS06845	COG2909	trisaccharide binding
CUB95_RS06850	COG2909	trisaccharide binding
CUB95_RS06855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUB95_RS06860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CUB95_RS06860	COG0517	IMP dehydrogenase activity
CUB95_RS06865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CUB95_RS06875	COG0811	peptide transport
CUB95_RS06905	COG0481	GTPase activity
CUB95_RS06920	COG0616	signal peptide processing
CUB95_RS06925	COG1663	tetraacyldisaccharide 4'-kinase activity
CUB95_RS06930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CUB95_RS06945	COG3634	alkyl hydroperoxide reductase activity
CUB95_RS06955	COG0148	phosphopyruvate hydratase activity
CUB95_RS06960	COG0583	DNA-binding transcription factor activity
CUB95_RS06975	COG0823	Involved in the tonB-independent uptake of proteins
CUB95_RS06975	COG1506	peptidase
CUB95_RS06980	COG0706	membrane insertase activity
CUB95_RS06985	COG0504	CTP synthase activity
CUB95_RS07000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUB95_RS07020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CUB95_RS07025	COG3754	Rhamnan synthesis protein F
CUB95_RS07050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUB95_RS07090	COG1139	Iron-sulfur cluster binding protein
CUB95_RS07130	COG1088	dTDP-glucose 4,6-dehydratase activity
CUB95_RS07165	COG2211	Major facilitator Superfamily
CUB95_RS07230	COG1242	4 iron, 4 sulfur cluster binding
CUB95_RS07265	COG1442	glycosyl transferase family 8
CUB95_RS07265	COG1216	Glycosyl transferase, family 2
CUB95_RS07275	COG1216	Glycosyl transferase, family 2
CUB95_RS07285	COG0205	6-phosphofructokinase activity
CUB95_RS07290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CUB95_RS07305	COG0356	it plays a direct role in the translocation of protons across the membrane
CUB95_RS07310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUB95_RS07315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CUB95_RS07320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUB95_RS07325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CUB95_RS07330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CUB95_RS07350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CUB95_RS07355	COG0134	indole-3-glycerol-phosphate synthase activity
CUB95_RS07360	COG0135	phosphoribosylanthranilate isomerase activity
CUB95_RS07365	COG0512	Glutamine amidotransferase of anthranilate synthase
CUB95_RS07390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CUB95_RS07410	COG1940	carbohydrate kinase activity
CUB95_RS07425	COG1595	DNA-templated transcription, initiation
CUB95_RS07440	COG1649	PFAM Uncharacterised BCR, COG1649
CUB95_RS07465	COG0336	Belongs to the RNA methyltransferase TrmD family
CUB95_RS07475	COG0006	proline dipeptidase activity
CUB95_RS07485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CUB95_RS07485	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CUB95_RS07495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CUB95_RS07500	COG0459	protein refolding
CUB95_RS07505	COG4335	DNA alkylation repair
CUB95_RS07510	COG0525	valine-tRNA ligase activity
CUB95_RS07515	COG3956	TIGRFAM MazG family protein
CUB95_RS07525	COG1234	tRNA 3'-trailer cleavage
CUB95_RS07545	COG0745	RESPONSE REGULATOR receiver
CUB95_RS07545	COG3292	Two component regulator propeller
CUB95_RS07545	COG2205	protein histidine kinase activity
CUB95_RS07565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUB95_RS07575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CUB95_RS07575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CUB95_RS07580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CUB95_RS07585	COG1078	dGTPase activity
CUB95_RS07590	COG0284	orotidine-5'-phosphate decarboxylase activity
CUB95_RS07595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CUB95_RS07600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CUB95_RS07605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CUB95_RS07610	COG2226	methyltransferase
CUB95_RS07615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CUB95_RS07620	COG1702	phosphate starvation-inducible protein PhoH
CUB95_RS07625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUB95_RS07640	COG1074	ATP-dependent DNA helicase activity
CUB95_RS07645	COG0582	viral genome integration into host DNA
CUB95_RS07685	COG0551	DNA topoisomerase type I activity
CUB95_RS07685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CUB95_RS07810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUB95_RS07815	COG1309	transcriptional regulator
CUB95_RS07865	COG0582	viral genome integration into host DNA
CUB95_RS07870	COG2957	Belongs to the agmatine deiminase family
CUB95_RS07890	COG0564	pseudouridine synthase activity
CUB95_RS07895	COG0484	heat shock protein binding
CUB95_RS07910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CUB95_RS07945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CUB95_RS07950	COG0124	histidyl-tRNA synthetase
CUB95_RS07985	COG2205	protein histidine kinase activity
CUB95_RS08030	COG0629	single-stranded DNA binding
CUB95_RS08035	COG4535	Mg2 and Co2 transporter CorC
CUB95_RS08050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CUB95_RS08070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CUB95_RS08090	COG0360	Binds together with S18 to 16S ribosomal RNA
CUB95_RS08095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CUB95_RS08100	COG0359	binds to the 23S rRNA
CUB95_RS08110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CUB95_RS08115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CUB95_RS08120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CUB95_RS08125	COG2183	response to ionizing radiation
CUB95_RS08135	COG0488	(ABC) transporter
CUB95_RS08140	COG3590	peptidase
CUB95_RS08155	COG0488	(ABC) transporter
CUB95_RS08160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CUB95_RS08165	COG0484	heat shock protein binding
CUB95_RS08180	COG0009	L-threonylcarbamoyladenylate synthase
CUB95_RS08190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CUB95_RS08205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CUB95_RS08210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUB95_RS08230	COG1215	transferase activity, transferring glycosyl groups
CUB95_RS08245	COG3594	Acyltransferase
CUB95_RS08260	COG1442	glycosyl transferase family 8
CUB95_RS08280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUB95_RS08305	COG1054	Belongs to the UPF0176 family
CUB95_RS08310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUB95_RS08315	COG3022	response to hydroperoxide
CUB95_RS08340	COG1373	ATPase (AAA superfamily
CUB95_RS08415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CUB95_RS08425	COG1649	PFAM Uncharacterised BCR, COG1649
CUB95_RS08430	COG1522	sequence-specific DNA binding
CUB95_RS08435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CUB95_RS08460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUB95_RS08470	COG0242	peptide deformylase activity
CUB95_RS08475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CUB95_RS08505	COG0574	Belongs to the PEP-utilizing enzyme family
CUB95_RS08505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUB95_RS08530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CUB95_RS08530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CUB95_RS08535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CUB95_RS08545	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CUB95_RS08560	COG0460	homoserine dehydrogenase
CUB95_RS08560	COG0527	aspartate kinase activity
CUB95_RS08565	COG2884	Cell division ATP-binding protein ftsE
CUB95_RS08610	COG1575	Belongs to the MenA family. Type 1 subfamily
CUB95_RS08620	COG0590	tRNA wobble adenosine to inosine editing
CUB95_RS08635	COG0656	L-ascorbic acid biosynthetic process
CUB95_RS08650	COG1597	lipid kinase activity
CUB95_RS08655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CUB95_RS08660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CUB95_RS08665	COG0343	queuine tRNA-ribosyltransferase activity
CUB95_RS08675	COG0513	Belongs to the DEAD box helicase family
CUB95_RS08680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CUB95_RS08695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CUB95_RS08700	COG0543	2 iron, 2 sulfur cluster binding
CUB95_RS08710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CUB95_RS08725	COG0346	lactoylglutathione lyase activity
CUB95_RS08730	COG1151	hydroxylamine reductase activity
CUB95_RS08745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUB95_RS08755	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CUB95_RS08770	COG3189	MarR family transcriptional regulator
CUB95_RS08800	COG2261	transglycosylase associated protein
CUB95_RS08815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUB95_RS08825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUB95_RS08845	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CUB95_RS08845	COG0662	Cupin 2, conserved barrel domain protein
CUB95_RS08860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CUB95_RS08880	COG1309	transcriptional regulator
CUB95_RS08895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUB95_RS08900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUB95_RS08905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUB95_RS08910	COG0509	glycine decarboxylation via glycine cleavage system
CUB95_RS08925	COG0228	four-way junction DNA binding
CUB95_RS08935	COG3757	hydrolase, family 25
CUB95_RS08945	COG0406	alpha-ribazole phosphatase activity
CUB95_RS08955	COG0572	uridine kinase
CUB95_RS08985	COG0254	rRNA binding
CUB95_RS09090	COG0010	Belongs to the arginase family
CUB95_RS09105	COG4974	Belongs to the 'phage' integrase family
CUB95_RS09110	COG4974	Belongs to the 'phage' integrase family
CUB95_RS09135	COG1530	ribonuclease E activity
CUB95_RS09145	COG4771	TonB-dependent receptor
CUB95_RS09155	COG0826	peptidase U32
CUB95_RS09175	COG3142	Participates in the control of copper homeostasis
CUB95_RS09190	COG2264	protein methyltransferase activity
CUB95_RS09225	COG1032	radical SAM domain protein
CUB95_RS09240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CUB95_RS09245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CUB95_RS09250	COG2860	membrane
CUB95_RS09260	COG3033	Beta-eliminating lyase
CUB95_RS09265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CUB95_RS09270	COG0494	nUDIX hydrolase
CUB95_RS09280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CUB95_RS09295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CUB95_RS09300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CUB95_RS09345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CUB95_RS09350	COG0698	ribose 5-phosphate isomerase
CUB95_RS09375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUB95_RS09380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CUB95_RS09415	COG0534	Mate efflux family protein
CUB95_RS09430	COG0697	spore germination
CUB95_RS09435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CUB95_RS09440	COG1722	exodeoxyribonuclease VII activity
CUB95_RS09445	COG1570	exodeoxyribonuclease VII activity
CUB95_RS09455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUB95_RS09460	COG0252	asparaginase activity
CUB95_RS09470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CUB95_RS09480	COG0505	Belongs to the CarA family
CUB95_RS09485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUB95_RS09500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB95_RS09535	COG0463	Glycosyl transferase, family 2
CUB95_RS09540	COG1477	protein flavinylation
CUB95_RS09550	COG0339	signal peptide processing
CUB95_RS09555	COG0590	tRNA wobble adenosine to inosine editing
CUB95_RS09560	COG0793	Belongs to the peptidase S41A family
CUB95_RS09575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUB95_RS09610	COG2204	response regulator
CUB95_RS09625	COG1660	Displays ATPase and GTPase activities
CUB95_RS09630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CUB95_RS09635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUB95_RS09635	COG0519	Catalyzes the synthesis of GMP from XMP
CUB95_RS09645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CUB95_RS09650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUB95_RS09670	COG0297	glycogen (starch) synthase activity
CUB95_RS09705	COG0561	phosphatase activity
CUB95_RS09735	COG0534	Mate efflux family protein
CUB95_RS09745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUB95_RS09750	COG0366	Alpha amylase catalytic
CUB95_RS09755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CUB95_RS09760	COG0101	tRNA pseudouridine synthase activity
CUB95_RS09765	COG2333	competence protein COMEC
CUB95_RS09765	COG0658	competence protein
CUB95_RS09785	COG4771	TonB-dependent receptor
CUB95_RS09790	COG1429	ligase activity, forming nitrogen-metal bonds
CUB95_RS09825	COG0739	heme binding
CUB95_RS09840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CUB95_RS09850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CUB95_RS09885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUB95_RS09970	COG1505	serine-type exopeptidase activity
CUB95_RS09985	COG0542	response to heat
CUB95_RS10000	COG0297	glycogen (starch) synthase activity
CUB95_RS10010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CUB95_RS10035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CUB95_RS10040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CUB95_RS10055	COG0673	inositol 2-dehydrogenase activity
CUB95_RS10070	COG3426	butyrate kinase activity
CUB95_RS10075	COG0280	phosphate acetyltransferase
CUB95_RS10095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUB95_RS10095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUB95_RS10105	COG0489	protein tyrosine kinase activity
CUB95_RS10190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CUB95_RS10200	COG0714	Associated with various cellular activities
CUB95_RS10215	COG2304	oxidoreductase activity
CUB95_RS10235	COG0671	phosphoesterase, PA-phosphatase related
CUB95_RS10240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUB95_RS10250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CUB95_RS10250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CUB95_RS10275	COG1309	transcriptional regulator
CUB95_RS10365	COG1882	Formate acetyltransferase
CUB95_RS10370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CUB95_RS10385	COG1592	Rubrerythrin
CUB95_RS10415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CUB95_RS10415	COG1918	ferrous iron import across plasma membrane
CUB95_RS10420	COG2855	membrane
CUB95_RS10440	COG0442	prolyl-tRNA aminoacylation
CUB95_RS10455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUB95_RS10480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CUB95_RS10490	COG0488	(ABC) transporter
CUB95_RS10495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CUB95_RS10500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUB95_RS10525	COG1058	Belongs to the CinA family
CUB95_RS10525	COG1546	Belongs to the CinA family
CUB95_RS10530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CUB95_RS10535	COG0024	Methionine aminopeptidase
CUB95_RS10570	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUB95_RS10595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CUB95_RS10600	COG0540	Belongs to the ATCase OTCase family
CUB95_RS10605	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CUB95_RS10610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CUB95_RS10625	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CUB95_RS10630	COG1805	sodium ion transport
CUB95_RS10635	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CUB95_RS10640	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CUB95_RS10645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CUB95_RS10650	COG2871	sodium ion transport
CUB95_RS10720	COG0542	response to heat
CUB95_RS10795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUB95_RS10800	COG0116	Belongs to the methyltransferase superfamily
CUB95_RS10805	COG0823	Involved in the tonB-independent uptake of proteins
CUB95_RS10805	COG1506	peptidase
CUB95_RS10820	COG2715	membrane protein required for spore maturation
CUB95_RS10830	COG3591	Belongs to the peptidase S1B family
CUB95_RS10895	COG1388	LysM domain
CUB95_RS10895	COG1705	Flagellar rod assembly protein muramidase FlgJ
CUB95_RS10905	COG0539	negative regulation of cytoplasmic translation
CUB95_RS10905	COG2183	response to ionizing radiation
CUB95_RS10915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CUB95_RS10950	COG1760	l-serine dehydratase
CUB95_RS10965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CUB95_RS10975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUB95_RS10980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUB95_RS10985	COG0523	cobalamin synthesis protein
CUB95_RS10995	COG1271	oxidase subunit
CUB95_RS11010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CUB95_RS11030	COG4221	oxidoreductase activity
CUB95_RS11040	COG0564	pseudouridine synthase activity
CUB95_RS11065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CUB95_RS11075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CUB95_RS11080	COG0424	maF-like protein
CUB95_RS11105	COG2226	methyltransferase
CUB95_RS11110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CUB95_RS11120	COG0552	protein localization to endoplasmic reticulum
CUB95_RS11125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUB95_RS11130	COG0776	regulation of translation
CUB95_RS11150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CUB95_RS11155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUB95_RS11160	COG0357	Ribosomal RNA small subunit methyltransferase G
CUB95_RS11170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUB95_RS11175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CUB95_RS11185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CUB95_RS11200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CUB95_RS11215	COG0492	ferredoxin-NADP+ reductase activity
CUB95_RS11220	COG1428	Deoxynucleoside kinase
CUB95_RS11240	COG0339	signal peptide processing
CUB95_RS11295	COG1131	(ABC) transporter
CUB95_RS11320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CUB95_RS11325	COG1193	negative regulation of DNA recombination
CUB95_RS11335	COG0037	tRNA processing
CUB95_RS11340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUB95_RS11350	COG1674	ftsk spoiiie
CUB95_RS11365	COG1295	ribonuclease BN
CUB95_RS11370	COG0326	Molecular chaperone. Has ATPase activity
CUB95_RS11375	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CUB95_RS11385	COG0305	Participates in initiation and elongation during chromosome replication
CUB95_RS11390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CUB95_RS11395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CUB95_RS11400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUB95_RS11445	COG0653	protein targeting
CUB95_RS11500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CUB95_RS11510	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CUB95_RS11525	COG0084	hydrolase, TatD family'
CUB95_RS11540	COG0217	transcriptional regulatory protein
CUB95_RS11545	COG2315	Protein conserved in bacteria
CUB95_RS11570	COG0592	DNA-directed DNA polymerase activity
CUB95_RS11575	COG2176	DNA-directed DNA polymerase activity
CUB95_RS11590	COG0497	DNA recombination
CUB95_RS11640	COG1595	DNA-templated transcription, initiation
CUB95_RS11670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB95_RS11675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB95_RS11680	COG0649	NAD binding
CUB95_RS11685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CUB95_RS11690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CUB95_RS11700	COG0713	ATP synthesis coupled electron transport
CUB95_RS11705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CUB95_RS11885	COG1404	Belongs to the peptidase S8 family
CUB95_RS11895	COG1404	Belongs to the peptidase S8 family
CUB95_RS11900	COG1733	regulation of RNA biosynthetic process
CUB95_RS11905	COG2910	NAD(P)H-binding
CUB95_RS11945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CUB95_RS11950	COG4974	Belongs to the 'phage' integrase family
CUB95_RS11990	COG0582	viral genome integration into host DNA
CUB95_RS12035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CUB95_RS12050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CUB95_RS12050	COG0551	DNA topoisomerase type I activity
CUB95_RS12070	COG0463	Glycosyl transferase, family 2
CUB95_RS12085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CUB95_RS12100	COG3279	Response regulator of the LytR AlgR family
CUB95_RS12105	COG3275	phosphorelay sensor kinase activity
CUB95_RS12155	COG0156	8-amino-7-oxononanoate synthase activity
CUB95_RS12320	COG4974	Belongs to the 'phage' integrase family
CUB95_RS12505	COG4974	Belongs to the 'phage' integrase family
CUB95_RS12580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CUB95_RS12580	COG2198	Histidine kinase
CUB95_RS12580	COG2205	protein histidine kinase activity
CUB95_RS12580	COG0784	Response regulator, receiver
CUB95_RS12780	COG0741	lytic transglycosylase activity
CUB95_RS12780	COG1196	nuclear chromosome segregation
CUB95_RS12780	COG0739	heme binding
CUB95_RS12795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUB95_RS12930	COG0582	viral genome integration into host DNA
CUB95_RS13020	COG1404	Belongs to the peptidase S8 family
CUB95_RS13045	COG1132	(ABC) transporter
CUB95_RS13080	COG0735	belongs to the Fur family
CUB95_RS13105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CUB95_RS13115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CUB95_RS13125	COG3550	peptidyl-serine autophosphorylation
CUB95_RS13150	COG0251	oxidation-reduction process
CUB95_RS13205	COG1373	ATPase (AAA superfamily
CUB95_RS13250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CUB95_RS13265	COG3655	Transcriptional regulator