locus-tag	class	description
CTM46_RS00025	COG0482	sulfurtransferase activity
CTM46_RS00030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTM46_RS00035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CTM46_RS00040	COG0126	phosphoglycerate kinase activity
CTM46_RS00050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CTM46_RS00100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CTM46_RS00115	COG2382	esterase
CTM46_RS00120	COG0191	fructose-bisphosphate aldolase activity
CTM46_RS00125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CTM46_RS00125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CTM46_RS00130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CTM46_RS00135	COG0563	adenylate kinase activity
CTM46_RS00140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTM46_RS00145	COG1496	oxidoreductase activity
CTM46_RS00155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTM46_RS00165	COG0842	Transport permease protein
CTM46_RS00170	COG1131	(ABC) transporter
CTM46_RS00185	COG2207	Transcriptional regulator
CTM46_RS00190	COG0673	inositol 2-dehydrogenase activity
CTM46_RS00200	COG0335	large ribosomal subunit rRNA binding
CTM46_RS00210	COG0737	Belongs to the 5'-nucleotidase family
CTM46_RS00225	COG2357	RelA SpoT domain protein
CTM46_RS00235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CTM46_RS00270	COG0358	DNA primase activity
CTM46_RS00275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTM46_RS00285	COG0203	ribosomal protein L17
CTM46_RS00290	COG0202	RNA polymerase activity
CTM46_RS00295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CTM46_RS00300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CTM46_RS00305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTM46_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CTM46_RS00315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CTM46_RS00320	COG0201	protein transport
CTM46_RS00325	COG0200	Binds to the 23S rRNA
CTM46_RS00330	COG1841	ribosomal large subunit assembly
CTM46_RS00335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTM46_RS00340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTM46_RS00345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTM46_RS00350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTM46_RS00355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTM46_RS00360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CTM46_RS00365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CTM46_RS00370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTM46_RS00375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTM46_RS00380	COG0255	Belongs to the universal ribosomal protein uL29 family
CTM46_RS00385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTM46_RS00390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTM46_RS00400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTM46_RS00405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CTM46_RS00410	COG0089	rRNA binding
CTM46_RS00415	COG0088	Forms part of the polypeptide exit tunnel
CTM46_RS00420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTM46_RS00425	COG0051	transcription antitermination factor activity, RNA binding
CTM46_RS00430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM46_RS00435	COG0049	tRNA binding
CTM46_RS00440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTM46_RS00490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTM46_RS00495	COG0085	RNA polymerase activity
CTM46_RS00500	COG0222	ribosome binding
CTM46_RS00505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CTM46_RS00510	COG0081	regulation of translation
CTM46_RS00515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CTM46_RS00535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTM46_RS00565	COG4974	Belongs to the 'phage' integrase family
CTM46_RS00570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CTM46_RS00585	COG0006	proline dipeptidase activity
CTM46_RS00635	COG0039	L-malate dehydrogenase activity
CTM46_RS00665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTM46_RS00670	COG1480	7TM receptor with intracellular HD hydrolase
CTM46_RS00680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTM46_RS00705	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CTM46_RS00750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CTM46_RS00765	COG2096	Adenosyltransferase
CTM46_RS00815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CTM46_RS00820	COG0426	domain, Protein
CTM46_RS00825	COG0612	Peptidase, M16
CTM46_RS00865	COG0756	dUTP diphosphatase activity
CTM46_RS00890	COG0280	phosphate acetyltransferase
CTM46_RS00895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTM46_RS00905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTM46_RS00910	COG0156	8-amino-7-oxononanoate synthase activity
CTM46_RS00930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CTM46_RS00940	COG0351	phosphomethylpyrimidine kinase
CTM46_RS00940	COG0352	thiamine-phosphate diphosphorylase activity
CTM46_RS00980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTM46_RS00980	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTM46_RS00985	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTM46_RS00990	COG0045	succinate-CoA ligase (ADP-forming) activity
CTM46_RS00995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CTM46_RS01030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM46_RS01030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTM46_RS01115	COG0537	adenosine 5'-monophosphoramidase activity
CTM46_RS01120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTM46_RS01125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTM46_RS01205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTM46_RS01230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTM46_RS01240	COG3341	Caulimovirus viroplasmin
CTM46_RS01240	COG0328	RNA-DNA hybrid ribonuclease activity
CTM46_RS01250	COG0018	arginyl-trna synthetase
CTM46_RS01255	COG1120	ATPase activity
CTM46_RS01265	COG1620	l-lactate permease
CTM46_RS01270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM46_RS01275	COG1132	(ABC) transporter
CTM46_RS01300	COG3475	LICD family
CTM46_RS01310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTM46_RS01325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTM46_RS01325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTM46_RS01330	COG2890	protein-(glutamine-N5) methyltransferase activity
CTM46_RS01350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CTM46_RS01365	COG0594	ribonuclease P activity
CTM46_RS01370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CTM46_RS01375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTM46_RS01400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTM46_RS01405	COG1283	sodium-dependent phosphate transmembrane transporter activity
CTM46_RS01410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTM46_RS01415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CTM46_RS01430	COG1438	arginine binding
CTM46_RS01435	COG1131	(ABC) transporter
CTM46_RS01455	COG3590	peptidase
CTM46_RS01465	COG1022	Amp-dependent synthetase and ligase
CTM46_RS01470	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CTM46_RS01475	COG2954	triphosphatase activity
CTM46_RS01520	COG3681	Belongs to the UPF0597 family
CTM46_RS01525	COG0351	phosphomethylpyrimidine kinase
CTM46_RS01530	COG0352	thiamine-phosphate diphosphorylase activity
CTM46_RS01535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTM46_RS01540	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CTM46_RS01545	COG0352	thiamine-phosphate diphosphorylase activity
CTM46_RS01555	COG3610	response to peptide
CTM46_RS01560	COG0583	DNA-binding transcription factor activity
CTM46_RS01575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CTM46_RS01580	COG0545	Peptidyl-prolyl cis-trans isomerase
CTM46_RS01595	COG1522	sequence-specific DNA binding
CTM46_RS01605	COG2234	aminopeptidase activity
CTM46_RS01615	COG3279	Response regulator of the LytR AlgR family
CTM46_RS01620	COG3275	phosphorelay sensor kinase activity
CTM46_RS01630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CTM46_RS01685	COG0606	chelatase, subunit chli
CTM46_RS01735	COG0702	epimerase
CTM46_RS01740	COG0557	exoribonuclease II activity
CTM46_RS01750	COG0564	pseudouridine synthase activity
CTM46_RS01775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTM46_RS01780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTM46_RS01790	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CTM46_RS01820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CTM46_RS01830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CTM46_RS01860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CTM46_RS01865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTM46_RS01870	COG0495	leucyl-tRNA aminoacylation
CTM46_RS01890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTM46_RS01895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTM46_RS01905	COG0012	GTP binding
CTM46_RS01910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTM46_RS01920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTM46_RS01925	COG0393	Putative heavy-metal-binding
CTM46_RS01930	COG0215	cysteine-tRNA ligase activity
CTM46_RS01935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CTM46_RS01945	COG2166	iron-sulfur cluster assembly
CTM46_RS01955	COG0826	peptidase U32
CTM46_RS01960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTM46_RS01960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTM46_RS01975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CTM46_RS01980	COG1694	Mazg nucleotide pyrophosphohydrolase
CTM46_RS01985	COG1490	D-aminoacyl-tRNA deacylase activity
CTM46_RS01990	COG0322	excinuclease ABC activity
CTM46_RS01995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTM46_RS02000	COG0445	tRNA wobble uridine modification
CTM46_RS02015	COG1053	succinate dehydrogenase
CTM46_RS02020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CTM46_RS02030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTM46_RS02035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CTM46_RS02045	COG0793	Belongs to the peptidase S41A family
CTM46_RS02065	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CTM46_RS02150	COG4974	Belongs to the 'phage' integrase family
CTM46_RS02170	COG1132	(ABC) transporter
CTM46_RS02175	COG1132	(ABC) transporter
CTM46_RS02230	COG1373	ATPase (AAA superfamily
CTM46_RS02270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM46_RS02295	COG0582	viral genome integration into host DNA
CTM46_RS02305	COG0622	Phosphoesterase
CTM46_RS02315	COG0758	DNA mediated transformation
CTM46_RS02335	COG0671	phosphoesterase, PA-phosphatase related
CTM46_RS02340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CTM46_RS02370	COG1373	ATPase (AAA superfamily
CTM46_RS02385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTM46_RS02430	COG0196	riboflavin kinase activity
CTM46_RS02530	COG2207	Transcriptional regulator
CTM46_RS02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTM46_RS02550	COG1185	polyribonucleotide nucleotidyltransferase activity
CTM46_RS02555	COG2217	Heavy metal translocating P-type atpase
CTM46_RS02570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTM46_RS02575	COG2255	four-way junction helicase activity
CTM46_RS02610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CTM46_RS02615	COG1166	arginine decarboxylase activity
CTM46_RS02630	COG2003	Belongs to the UPF0758 family
CTM46_RS02635	COG1216	Glycosyl transferase, family 2
CTM46_RS02640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTM46_RS02645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CTM46_RS02655	COG0564	pseudouridine synthase activity
CTM46_RS02660	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTM46_RS02685	COG4591	ABC-type transport system involved in lipoprotein release permease component
CTM46_RS02690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CTM46_RS02695	COG1162	GTPase activity
CTM46_RS02705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTM46_RS02710	COG0569	domain protein
CTM46_RS02715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTM46_RS02730	COG0670	Belongs to the BI1 family
CTM46_RS02785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM46_RS02810	COG2755	lipolytic protein G-D-S-L family
CTM46_RS02810	COG0657	acetylesterase activity
CTM46_RS02860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTM46_RS02865	COG0779	Required for maturation of 30S ribosomal subunits
CTM46_RS02870	COG0195	Participates in both transcription termination and antitermination
CTM46_RS02875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CTM46_RS02880	COG0719	Fe-S assembly protein
CTM46_RS02890	COG0396	ATPase activity
CTM46_RS02895	COG0719	Fe-S assembly protein
CTM46_RS02900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTM46_RS02910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTM46_RS02920	COG1629	transport
CTM46_RS02945	COG1404	Belongs to the peptidase S8 family
CTM46_RS02955	COG0793	Belongs to the peptidase S41A family
CTM46_RS02970	COG0058	SHG alpha-glucan phosphorylase activity
CTM46_RS03005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CTM46_RS03010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CTM46_RS03035	COG1595	DNA-templated transcription, initiation
CTM46_RS03045	COG1381	Involved in DNA repair and RecF pathway recombination
CTM46_RS03055	COG0268	Binds directly to 16S ribosomal RNA
CTM46_RS03065	COG0187	DNA topoisomerase II activity
CTM46_RS03075	COG0612	Peptidase, M16
CTM46_RS03105	COG2001	Belongs to the MraZ family
CTM46_RS03110	COG0275	rRNA processing
CTM46_RS03120	COG0768	penicillin binding
CTM46_RS03125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTM46_RS03130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTM46_RS03135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTM46_RS03140	COG0772	Belongs to the SEDS family
CTM46_RS03145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTM46_RS03150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTM46_RS03165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTM46_RS03210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CTM46_RS03215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CTM46_RS03235	COG1216	Glycosyl transferase, family 2
CTM46_RS03240	COG0438	transferase activity, transferring glycosyl groups
CTM46_RS03245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTM46_RS03280	COG0194	GDP metabolic process
CTM46_RS03285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CTM46_RS03295	COG1216	Glycosyl transferase, family 2
CTM46_RS03315	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CTM46_RS03340	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CTM46_RS03365	COG0252	asparaginase activity
CTM46_RS03370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CTM46_RS03375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CTM46_RS03390	COG0739	heme binding
CTM46_RS03395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTM46_RS03400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTM46_RS03410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTM46_RS03450	COG2211	Major facilitator Superfamily
CTM46_RS03460	COG1629	transport
CTM46_RS03460	COG4206	TonB-dependent receptor
CTM46_RS03475	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CTM46_RS03500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTM46_RS03505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTM46_RS03510	COG0052	Belongs to the universal ribosomal protein uS2 family
CTM46_RS03515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTM46_RS03525	COG0179	Fumarylacetoacetate (FAA) hydrolase
CTM46_RS03540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTM46_RS03570	COG3475	LICD family
CTM46_RS03575	COG0750	zinc metalloprotease
CTM46_RS03580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTM46_RS03585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTM46_RS03590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTM46_RS03600	COG1214	PFAM Peptidase M22, glycoprotease
CTM46_RS03615	COG0366	Alpha amylase catalytic
CTM46_RS03620	COG1523	belongs to the glycosyl hydrolase 13 family
CTM46_RS03625	COG1082	Xylose isomerase domain protein TIM barrel
CTM46_RS03630	COG1640	4-alpha-glucanotransferase
CTM46_RS03635	COG2081	HI0933 family
CTM46_RS03650	COG1621	beta-fructofuranosidase activity
CTM46_RS03660	COG3292	Two component regulator propeller
CTM46_RS03660	COG2205	protein histidine kinase activity
CTM46_RS03660	COG0745	RESPONSE REGULATOR receiver
CTM46_RS03690	COG2033	superoxide reductase activity
CTM46_RS03725	COG0659	secondary active sulfate transmembrane transporter activity
CTM46_RS03750	COG0741	lytic transglycosylase activity
CTM46_RS03760	COG1475	DNA binding
CTM46_RS03765	COG1192	Involved in chromosome partitioning
CTM46_RS03770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CTM46_RS03775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM46_RS03785	COG0586	Pfam SNARE associated Golgi protein
CTM46_RS03800	COG0423	glycine-tRNA ligase activity
CTM46_RS03820	COG0793	Belongs to the peptidase S41A family
CTM46_RS03825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTM46_RS03830	COG0544	peptidyl-prolyl cis-trans isomerase activity
CTM46_RS03835	COG0740	serine-type endopeptidase activity
CTM46_RS03840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTM46_RS03845	COG0514	ATP-dependent DNA helicase (RecQ)
CTM46_RS03855	COG4974	Belongs to the 'phage' integrase family
CTM46_RS03865	COG4974	Belongs to the 'phage' integrase family
CTM46_RS03880	COG0517	IMP dehydrogenase activity
CTM46_RS03880	COG0516	GMP reductase activity
CTM46_RS03885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTM46_RS03905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTM46_RS03930	COG0488	(ABC) transporter
CTM46_RS03935	COG1137	ATPase activity
CTM46_RS03940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CTM46_RS03945	COG1127	ABC transporter
CTM46_RS03955	COG1160	GTP binding
CTM46_RS03960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTM46_RS03965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTM46_RS03985	COG4191	Histidine kinase
CTM46_RS04025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTM46_RS04085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTM46_RS04100	COG4974	Belongs to the 'phage' integrase family
CTM46_RS04105	COG0582	viral genome integration into host DNA
CTM46_RS04110	COG1162	GTPase activity
CTM46_RS04115	COG0233	cytoplasmic translational termination
CTM46_RS04125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTM46_RS04135	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM46_RS04140	COG0598	Magnesium transport protein CorA
CTM46_RS04160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTM46_RS04170	COG4771	TonB-dependent receptor
CTM46_RS04225	COG3279	Response regulator of the LytR AlgR family
CTM46_RS04230	COG4659	FMN binding
CTM46_RS04235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CTM46_RS04240	COG0475	glutathione-regulated potassium exporter activity
CTM46_RS04240	COG0589	response to stress
CTM46_RS04245	COG1136	(ABC) transporter
CTM46_RS04250	COG2996	Protein conserved in bacteria
CTM46_RS04270	COG1397	ADP-ribosylglycohydrolase
CTM46_RS04295	COG0848	biopolymer transport protein
CTM46_RS04305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTM46_RS04320	COG1733	regulation of RNA biosynthetic process
CTM46_RS04340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CTM46_RS04355	COG0138	bifunctional purine biosynthesis protein purh
CTM46_RS04375	COG0768	penicillin binding
CTM46_RS04380	COG0772	Belongs to the SEDS family
CTM46_RS04385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTM46_RS04400	COG4974	Belongs to the 'phage' integrase family
CTM46_RS04405	COG4974	Belongs to the 'phage' integrase family
CTM46_RS04490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTM46_RS04520	COG2885	chlorophyll binding
CTM46_RS04550	COG4232	protein-disulfide reductase activity
CTM46_RS04555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTM46_RS04575	COG0792	nuclease activity
CTM46_RS04580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CTM46_RS04580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CTM46_RS04585	COG0528	UMP kinase activity
CTM46_RS04590	COG0802	atpase or kinase
CTM46_RS04595	COG0745	RESPONSE REGULATOR receiver
CTM46_RS04610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTM46_RS04635	COG1183	phosphatidylcholine synthase activity
CTM46_RS04640	COG0688	phosphatidylethanolamine metabolic process
CTM46_RS04665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM46_RS04705	COG1968	undecaprenyl-diphosphatase activity
CTM46_RS04710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTM46_RS04715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTM46_RS04720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTM46_RS04725	COG0783	Belongs to the Dps family
CTM46_RS04735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTM46_RS04740	COG1217	gtp-binding protein TYPA
CTM46_RS04760	COG1854	S-ribosylhomocysteine lyase activity
CTM46_RS04765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTM46_RS04790	COG0149	triose-phosphate isomerase activity
CTM46_RS04800	COG0302	gtp cyclohydrolase
CTM46_RS04805	COG0708	Exodeoxyribonuclease III
CTM46_RS04815	COG1696	Membrane protein involved in D-alanine export
CTM46_RS04835	COG2233	PERMEase
CTM46_RS04840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTM46_RS04880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTM46_RS04890	COG0612	Peptidase, M16
CTM46_RS04895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CTM46_RS04895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CTM46_RS04910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTM46_RS04915	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTM46_RS04915	COG1388	LysM domain
CTM46_RS04935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CTM46_RS04965	COG1720	tRNA m6t6A37 methyltransferase activity
CTM46_RS04975	COG0542	response to heat
CTM46_RS05000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTM46_RS05020	COG1404	Belongs to the peptidase S8 family
CTM46_RS05020	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CTM46_RS05025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CTM46_RS05030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTM46_RS05035	COG0157	Belongs to the NadC ModD family
CTM46_RS05040	COG0716	FMN binding
CTM46_RS05095	COG2217	Heavy metal translocating P-type atpase
CTM46_RS05100	COG2217	Heavy metal translocating P-type atpase
CTM46_RS05105	COG1418	mRNA catabolic process
CTM46_RS05125	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CTM46_RS05130	COG0489	protein tyrosine kinase activity
CTM46_RS05150	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTM46_RS05165	COG1228	amidohydrolase
CTM46_RS05170	COG2986	histidine ammonia-lyase
CTM46_RS05175	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CTM46_RS05185	COG2017	converts alpha-aldose to the beta-anomer
CTM46_RS05200	COG2909	trisaccharide binding
CTM46_RS05205	COG2909	trisaccharide binding
CTM46_RS05210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTM46_RS05215	COG0517	IMP dehydrogenase activity
CTM46_RS05215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CTM46_RS05220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CTM46_RS05230	COG0811	peptide transport
CTM46_RS05260	COG0481	GTPase activity
CTM46_RS05275	COG0616	signal peptide processing
CTM46_RS05280	COG1663	tetraacyldisaccharide 4'-kinase activity
CTM46_RS05285	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CTM46_RS05305	COG3634	alkyl hydroperoxide reductase activity
CTM46_RS05315	COG0148	phosphopyruvate hydratase activity
CTM46_RS05320	COG0583	DNA-binding transcription factor activity
CTM46_RS05335	COG0823	Involved in the tonB-independent uptake of proteins
CTM46_RS05335	COG1506	peptidase
CTM46_RS05340	COG0706	membrane insertase activity
CTM46_RS05345	COG0504	CTP synthase activity
CTM46_RS05365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTM46_RS05385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTM46_RS05390	COG3754	Rhamnan synthesis protein F
CTM46_RS05415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTM46_RS05475	COG1139	Iron-sulfur cluster binding protein
CTM46_RS05520	COG1088	dTDP-glucose 4,6-dehydratase activity
CTM46_RS05555	COG2211	Major facilitator Superfamily
CTM46_RS05630	COG1242	4 iron, 4 sulfur cluster binding
CTM46_RS05660	COG1442	glycosyl transferase family 8
CTM46_RS05660	COG1216	Glycosyl transferase, family 2
CTM46_RS05665	COG1442	glycosyl transferase family 8
CTM46_RS05665	COG1216	Glycosyl transferase, family 2
CTM46_RS05675	COG1216	Glycosyl transferase, family 2
CTM46_RS05685	COG0205	6-phosphofructokinase activity
CTM46_RS05690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTM46_RS05705	COG0356	it plays a direct role in the translocation of protons across the membrane
CTM46_RS05710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM46_RS05715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTM46_RS05720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTM46_RS05725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CTM46_RS05730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTM46_RS05750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTM46_RS05755	COG0134	indole-3-glycerol-phosphate synthase activity
CTM46_RS05760	COG0135	phosphoribosylanthranilate isomerase activity
CTM46_RS05765	COG0512	Glutamine amidotransferase of anthranilate synthase
CTM46_RS05800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CTM46_RS05820	COG1940	carbohydrate kinase activity
CTM46_RS05830	COG1595	DNA-templated transcription, initiation
CTM46_RS05845	COG1649	PFAM Uncharacterised BCR, COG1649
CTM46_RS05865	COG0336	Belongs to the RNA methyltransferase TrmD family
CTM46_RS05875	COG0006	proline dipeptidase activity
CTM46_RS05885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTM46_RS05885	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTM46_RS05895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CTM46_RS05900	COG0459	protein refolding
CTM46_RS05905	COG4335	DNA alkylation repair
CTM46_RS05910	COG0525	valine-tRNA ligase activity
CTM46_RS05915	COG3956	TIGRFAM MazG family protein
CTM46_RS05925	COG1234	tRNA 3'-trailer cleavage
CTM46_RS05945	COG2205	protein histidine kinase activity
CTM46_RS05945	COG0745	RESPONSE REGULATOR receiver
CTM46_RS05945	COG3292	Two component regulator propeller
CTM46_RS05965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTM46_RS05975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CTM46_RS05975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTM46_RS05980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTM46_RS05985	COG1078	dGTPase activity
CTM46_RS05990	COG0284	orotidine-5'-phosphate decarboxylase activity
CTM46_RS05995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTM46_RS06000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTM46_RS06005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTM46_RS06010	COG2226	methyltransferase
CTM46_RS06015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CTM46_RS06020	COG1702	phosphate starvation-inducible protein PhoH
CTM46_RS06025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CTM46_RS06035	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CTM46_RS06040	COG1074	ATP-dependent DNA helicase activity
CTM46_RS06045	COG2957	Belongs to the agmatine deiminase family
CTM46_RS06065	COG0564	pseudouridine synthase activity
CTM46_RS06075	COG0484	heat shock protein binding
CTM46_RS06090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTM46_RS06125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTM46_RS06130	COG0124	histidyl-tRNA synthetase
CTM46_RS06165	COG4251	negative regulation of phosphorylation
CTM46_RS06210	COG0629	single-stranded DNA binding
CTM46_RS06215	COG4535	Mg2 and Co2 transporter CorC
CTM46_RS06230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTM46_RS06240	COG1929	Belongs to the glycerate kinase type-1 family
CTM46_RS06250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CTM46_RS06270	COG0360	Binds together with S18 to 16S ribosomal RNA
CTM46_RS06275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CTM46_RS06280	COG0359	binds to the 23S rRNA
CTM46_RS06290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTM46_RS06295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CTM46_RS06300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CTM46_RS06305	COG2183	response to ionizing radiation
CTM46_RS06310	COG0488	(ABC) transporter
CTM46_RS06315	COG3590	peptidase
CTM46_RS06335	COG0488	(ABC) transporter
CTM46_RS06340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CTM46_RS06345	COG0484	heat shock protein binding
CTM46_RS06360	COG0009	L-threonylcarbamoyladenylate synthase
CTM46_RS06370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTM46_RS06385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTM46_RS06400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTM46_RS06435	COG1216	Glycosyl transferase, family 2
CTM46_RS06455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CTM46_RS06505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTM46_RS06530	COG1054	Belongs to the UPF0176 family
CTM46_RS06540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CTM46_RS06545	COG3022	response to hydroperoxide
CTM46_RS06575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CTM46_RS06585	COG1649	PFAM Uncharacterised BCR, COG1649
CTM46_RS06590	COG1522	sequence-specific DNA binding
CTM46_RS06600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CTM46_RS06625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTM46_RS06650	COG0242	peptide deformylase activity
CTM46_RS06655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTM46_RS06685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTM46_RS06685	COG0574	Belongs to the PEP-utilizing enzyme family
CTM46_RS06705	COG2885	chlorophyll binding
CTM46_RS06715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CTM46_RS06720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CTM46_RS06725	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CTM46_RS06740	COG0527	aspartate kinase activity
CTM46_RS06740	COG0460	homoserine dehydrogenase
CTM46_RS06745	COG2884	Cell division ATP-binding protein ftsE
CTM46_RS06795	COG1575	Belongs to the MenA family. Type 1 subfamily
CTM46_RS06805	COG0590	tRNA wobble adenosine to inosine editing
CTM46_RS06830	COG0656	L-ascorbic acid biosynthetic process
CTM46_RS06845	COG1597	lipid kinase activity
CTM46_RS06850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTM46_RS06855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTM46_RS06860	COG0343	queuine tRNA-ribosyltransferase activity
CTM46_RS06870	COG0513	Belongs to the DEAD box helicase family
CTM46_RS06875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTM46_RS06890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTM46_RS06895	COG0543	2 iron, 2 sulfur cluster binding
CTM46_RS06905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTM46_RS06920	COG0346	lactoylglutathione lyase activity
CTM46_RS06930	COG1151	hydroxylamine reductase activity
CTM46_RS06945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CTM46_RS06955	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CTM46_RS06970	COG3189	MarR family transcriptional regulator
CTM46_RS06990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTM46_RS07000	COG2261	transglycosylase associated protein
CTM46_RS07010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTM46_RS07020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTM46_RS07040	COG0662	Cupin 2, conserved barrel domain protein
CTM46_RS07040	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CTM46_RS07055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTM46_RS07075	COG1309	transcriptional regulator
CTM46_RS07085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTM46_RS07090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CTM46_RS07095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CTM46_RS07100	COG0509	glycine decarboxylation via glycine cleavage system
CTM46_RS07115	COG0228	four-way junction DNA binding
CTM46_RS07125	COG3757	hydrolase, family 25
CTM46_RS07135	COG0406	alpha-ribazole phosphatase activity
CTM46_RS07145	COG0572	uridine kinase
CTM46_RS07175	COG0254	rRNA binding
CTM46_RS07230	COG1530	ribonuclease E activity
CTM46_RS07235	COG4771	TonB-dependent receptor
CTM46_RS07245	COG0826	peptidase U32
CTM46_RS07265	COG3142	Participates in the control of copper homeostasis
CTM46_RS07290	COG1032	radical SAM domain protein
CTM46_RS07325	COG2264	protein methyltransferase activity
CTM46_RS07360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTM46_RS07365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTM46_RS07370	COG2860	membrane
CTM46_RS07390	COG3033	Beta-eliminating lyase
CTM46_RS07395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CTM46_RS07400	COG0494	nUDIX hydrolase
CTM46_RS07410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTM46_RS07425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTM46_RS07430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTM46_RS07480	COG0698	ribose 5-phosphate isomerase
CTM46_RS07505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CTM46_RS07510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTM46_RS07535	COG4974	Belongs to the 'phage' integrase family
CTM46_RS07540	COG4974	Belongs to the 'phage' integrase family
CTM46_RS07620	COG0156	8-amino-7-oxononanoate synthase activity
CTM46_RS07645	COG0534	Mate efflux family protein
CTM46_RS07665	COG0697	spore germination
CTM46_RS07670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTM46_RS07675	COG1722	exodeoxyribonuclease VII activity
CTM46_RS07680	COG1570	exodeoxyribonuclease VII activity
CTM46_RS07690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTM46_RS07695	COG0252	asparaginase activity
CTM46_RS07705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTM46_RS07715	COG0505	Belongs to the CarA family
CTM46_RS07720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTM46_RS07735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM46_RS07775	COG1477	protein flavinylation
CTM46_RS07785	COG0339	signal peptide processing
CTM46_RS07790	COG0590	tRNA wobble adenosine to inosine editing
CTM46_RS07795	COG0793	Belongs to the peptidase S41A family
CTM46_RS07810	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTM46_RS07845	COG2204	response regulator
CTM46_RS07860	COG1660	Displays ATPase and GTPase activities
CTM46_RS07865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CTM46_RS07870	COG0519	Catalyzes the synthesis of GMP from XMP
CTM46_RS07870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CTM46_RS07885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CTM46_RS07890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTM46_RS07910	COG0297	glycogen (starch) synthase activity
CTM46_RS07940	COG0561	phosphatase activity
CTM46_RS07960	COG0534	Mate efflux family protein
CTM46_RS07970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTM46_RS07975	COG0366	Alpha amylase catalytic
CTM46_RS07980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTM46_RS07985	COG0101	tRNA pseudouridine synthase activity
CTM46_RS07990	COG0658	competence protein
CTM46_RS07990	COG2333	competence protein COMEC
CTM46_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
CTM46_RS08000	COG4591	ABC-type transport system involved in lipoprotein release permease component
CTM46_RS08025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTM46_RS08030	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CTM46_RS08035	COG2818	Glycosylase
CTM46_RS08040	COG1215	transferase activity, transferring glycosyl groups
CTM46_RS08040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CTM46_RS08070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTM46_RS08090	COG0513	Belongs to the DEAD box helicase family
CTM46_RS08095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CTM46_RS08100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CTM46_RS08110	COG1739	Uncharacterized protein family UPF0029
CTM46_RS08130	COG4206	TonB-dependent receptor
CTM46_RS08150	COG0628	permease
CTM46_RS08160	COG1482	cell wall glycoprotein biosynthetic process
CTM46_RS08180	COG0222	ribosome binding
CTM46_RS08205	COG0612	Peptidase, M16
CTM46_RS08210	COG0470	DNA polymerase III
CTM46_RS08215	COG1774	PSP1 C-terminal conserved region
CTM46_RS08225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTM46_RS08275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CTM46_RS08285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTM46_RS08300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTM46_RS08315	COG0737	Belongs to the 5'-nucleotidase family
CTM46_RS08320	COG2816	NAD+ diphosphatase activity
CTM46_RS08325	COG2252	PERMEase
CTM46_RS08335	COG0471	metal ion transport
CTM46_RS08345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTM46_RS08350	COG2233	PERMEase
CTM46_RS08360	COG0463	Glycosyl transferase, family 2
CTM46_RS08365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTM46_RS08370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTM46_RS08445	COG1047	Peptidyl-prolyl cis-trans
CTM46_RS08450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CTM46_RS08455	COG0167	dihydroorotate dehydrogenase activity
CTM46_RS08460	COG0543	2 iron, 2 sulfur cluster binding
CTM46_RS08490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CTM46_RS08495	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM46_RS08500	COG0475	glutathione-regulated potassium exporter activity
CTM46_RS08540	COG2985	domain, Protein
CTM46_RS08540	COG0569	domain protein
CTM46_RS08550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CTM46_RS08555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTM46_RS08570	COG0071	Belongs to the small heat shock protein (HSP20) family
CTM46_RS08580	COG0237	dephospho-CoA kinase activity
CTM46_RS08590	COG1862	Preprotein translocase
CTM46_RS08595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTM46_RS08600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CTM46_RS08605	COG0193	aminoacyl-tRNA hydrolase activity
CTM46_RS08615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTM46_RS08625	COG2027	D-alanyl-D-alanine carboxypeptidase
CTM46_RS08630	COG0668	transmembrane transport
CTM46_RS08655	COG1960	acyl-CoA dehydrogenase activity
CTM46_RS08665	COG2086	electron transfer activity
CTM46_RS08670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTM46_RS08675	COG0166	Belongs to the GPI family
CTM46_RS08680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CTM46_RS08685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTM46_RS08700	COG2050	protein possibly involved in aromatic compounds catabolism
CTM46_RS08705	COG1169	isochorismate synthase
CTM46_RS08710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CTM46_RS08715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CTM46_RS08730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTM46_RS08745	COG0138	bifunctional purine biosynthesis protein purh
CTM46_RS08760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CTM46_RS08770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTM46_RS08790	COG1187	pseudouridine synthase activity
CTM46_RS08800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CTM46_RS08800	COG0515	serine threonine protein kinase
CTM46_RS08820	COG0632	four-way junction helicase activity
CTM46_RS08830	COG0742	ribosomal rna small subunit methyltransferase
CTM46_RS08855	COG4974	Belongs to the 'phage' integrase family
CTM46_RS08880	COG1755	Isoprenylcysteine carboxyl methyltransferase
CTM46_RS08900	COG0582	viral genome integration into host DNA
CTM46_RS08905	COG4584	PFAM Integrase catalytic
CTM46_RS08905	COG2390	Transcriptional regulator
CTM46_RS08910	COG1484	DNA-dependent DNA replication
CTM46_RS09065	COG4974	Belongs to the 'phage' integrase family
CTM46_RS09085	COG1404	Belongs to the peptidase S8 family
CTM46_RS09120	COG1132	(ABC) transporter
CTM46_RS09185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CTM46_RS09190	COG0732	type I restriction modification DNA specificity domain
CTM46_RS09195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CTM46_RS09240	COG0251	oxidation-reduction process
CTM46_RS09285	COG1373	ATPase (AAA superfamily
CTM46_RS09330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTM46_RS09345	COG3655	Transcriptional regulator
CTM46_RS09350	COG0612	Peptidase, M16
CTM46_RS09360	COG4771	TonB-dependent receptor
CTM46_RS09365	COG1429	ligase activity, forming nitrogen-metal bonds
CTM46_RS09410	COG0739	heme binding
CTM46_RS09425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CTM46_RS09435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTM46_RS09470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTM46_RS09540	COG1505	serine-type exopeptidase activity
CTM46_RS09565	COG0542	response to heat
CTM46_RS09580	COG0297	glycogen (starch) synthase activity
CTM46_RS09590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CTM46_RS09600	COG1401	restriction endodeoxyribonuclease activity
CTM46_RS09625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTM46_RS09630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CTM46_RS09645	COG0673	inositol 2-dehydrogenase activity
CTM46_RS09665	COG3426	butyrate kinase activity
CTM46_RS09670	COG0280	phosphate acetyltransferase
CTM46_RS09695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTM46_RS09695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTM46_RS09715	COG0489	protein tyrosine kinase activity
CTM46_RS09785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTM46_RS09800	COG0714	Associated with various cellular activities
CTM46_RS09815	COG2304	oxidoreductase activity
CTM46_RS09835	COG0671	phosphoesterase, PA-phosphatase related
CTM46_RS09840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTM46_RS09850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTM46_RS09850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTM46_RS09875	COG1309	transcriptional regulator
CTM46_RS09965	COG1882	Formate acetyltransferase
CTM46_RS09970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CTM46_RS09990	COG1592	Rubrerythrin
CTM46_RS10025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTM46_RS10025	COG1918	ferrous iron import across plasma membrane
CTM46_RS10030	COG2855	membrane
CTM46_RS10045	COG0442	prolyl-tRNA aminoacylation
CTM46_RS10055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTM46_RS10080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTM46_RS10095	COG0488	(ABC) transporter
CTM46_RS10100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTM46_RS10105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTM46_RS10125	COG1058	Belongs to the CinA family
CTM46_RS10125	COG1546	Belongs to the CinA family
CTM46_RS10130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTM46_RS10135	COG0024	Methionine aminopeptidase
CTM46_RS10165	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTM46_RS10190	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CTM46_RS10195	COG0540	Belongs to the ATCase OTCase family
CTM46_RS10200	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CTM46_RS10205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CTM46_RS10220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CTM46_RS10225	COG1805	sodium ion transport
CTM46_RS10230	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CTM46_RS10235	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CTM46_RS10240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CTM46_RS10245	COG2871	sodium ion transport
CTM46_RS10385	COG0542	response to heat
CTM46_RS10445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTM46_RS10450	COG0116	Belongs to the methyltransferase superfamily
CTM46_RS10455	COG1506	peptidase
CTM46_RS10455	COG0823	Involved in the tonB-independent uptake of proteins
CTM46_RS10470	COG2715	membrane protein required for spore maturation
CTM46_RS10480	COG3591	Belongs to the peptidase S1B family
CTM46_RS10540	COG1388	LysM domain
CTM46_RS10540	COG1705	Flagellar rod assembly protein muramidase FlgJ
CTM46_RS10550	COG0539	negative regulation of cytoplasmic translation
CTM46_RS10550	COG2183	response to ionizing radiation
CTM46_RS10555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTM46_RS10585	COG1760	l-serine dehydratase
CTM46_RS10600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTM46_RS10610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTM46_RS10615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CTM46_RS10620	COG0523	cobalamin synthesis protein
CTM46_RS10635	COG1271	oxidase subunit
CTM46_RS10650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTM46_RS10670	COG4221	oxidoreductase activity
CTM46_RS10680	COG0564	pseudouridine synthase activity
CTM46_RS10705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CTM46_RS10715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CTM46_RS10720	COG0424	maF-like protein
CTM46_RS10745	COG2226	methyltransferase
CTM46_RS10750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CTM46_RS10760	COG0552	protein localization to endoplasmic reticulum
CTM46_RS10765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTM46_RS10770	COG0776	regulation of translation
CTM46_RS10790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CTM46_RS10795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTM46_RS10800	COG0357	Ribosomal RNA small subunit methyltransferase G
CTM46_RS10810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTM46_RS10815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CTM46_RS10825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CTM46_RS10840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTM46_RS10855	COG0492	ferredoxin-NADP+ reductase activity
CTM46_RS10860	COG1428	Deoxynucleoside kinase
CTM46_RS10885	COG0339	signal peptide processing
CTM46_RS10985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CTM46_RS10990	COG1193	negative regulation of DNA recombination
CTM46_RS10995	COG0037	tRNA processing
CTM46_RS11000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CTM46_RS11010	COG1674	ftsk spoiiie
CTM46_RS11030	COG1295	ribonuclease BN
CTM46_RS11040	COG0326	Molecular chaperone. Has ATPase activity
CTM46_RS11045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CTM46_RS11055	COG0305	Participates in initiation and elongation during chromosome replication
CTM46_RS11060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CTM46_RS11080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CTM46_RS11085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CTM46_RS11140	COG0653	protein targeting
CTM46_RS11185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CTM46_RS11195	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CTM46_RS11210	COG0084	hydrolase, TatD family'
CTM46_RS11225	COG0217	transcriptional regulatory protein
CTM46_RS11245	COG0592	DNA-directed DNA polymerase activity
CTM46_RS11250	COG2176	DNA-directed DNA polymerase activity
CTM46_RS11265	COG0497	DNA recombination
CTM46_RS11315	COG1595	DNA-templated transcription, initiation
CTM46_RS11335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTM46_RS11340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTM46_RS11345	COG0649	NAD binding
CTM46_RS11350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CTM46_RS11355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTM46_RS11365	COG0713	ATP synthesis coupled electron transport
CTM46_RS11370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CTM46_RS11375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTM46_RS11545	COG1404	Belongs to the peptidase S8 family
CTM46_RS11550	COG1733	regulation of RNA biosynthetic process
CTM46_RS11555	COG2910	NAD(P)H-binding
CTM46_RS11575	COG3250	beta-galactosidase activity
CTM46_RS11635	COG0210	DNA helicase
CTM46_RS11675	COG1404	Belongs to the peptidase S8 family
CTM46_RS11700	COG4974	Belongs to the 'phage' integrase family
CTM46_RS11715	COG0551	DNA topoisomerase type I activity
CTM46_RS11715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTM46_RS11735	COG0463	Glycosyl transferase, family 2
CTM46_RS11750	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CTM46_RS11765	COG3279	Response regulator of the LytR AlgR family
CTM46_RS11770	COG3275	phosphorelay sensor kinase activity
CTM46_RS11790	COG2801	Transposase and inactivated derivatives
CTM46_RS11790	COG3415	Transposase
CTM46_RS11825	COG0156	8-amino-7-oxononanoate synthase activity
CTM46_RS11975	COG4974	Belongs to the 'phage' integrase family
CTM46_RS11980	COG4974	Belongs to the 'phage' integrase family
CTM46_RS11985	COG4974	Belongs to the 'phage' integrase family
CTM46_RS12025	COG4974	Belongs to the 'phage' integrase family
CTM46_RS12050	COG3843	relaxase mobilization nuclease domain protein
CTM46_RS12080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTM46_RS12095	COG1373	ATPase (AAA superfamily