locus-tag	class	description
P9215_RS00005	COG0592	DNA-directed DNA polymerase activity
P9215_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P9215_RS00020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
P9215_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P9215_RS00045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P9215_RS00050	COG0552	protein localization to endoplasmic reticulum
P9215_RS00055	COG2208	phosphoserine phosphatase activity
P9215_RS00060	COG0165	Argininosuccinate lyase
P9215_RS00065	COG0724	RNA recognition motif
P9215_RS00070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P9215_RS00075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P9215_RS00080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P9215_RS00085	COG0484	heat shock protein binding
P9215_RS00095	COG1162	GTPase activity
P9215_RS00100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
P9215_RS00105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
P9215_RS00110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P9215_RS00115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P9215_RS00120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P9215_RS00125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P9215_RS00130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P9215_RS00135	COG0511	ligase activity, forming carbon-carbon bonds
P9215_RS00140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
P9215_RS00175	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
P9215_RS00180	COG0519	Catalyzes the synthesis of GMP from XMP
P9215_RS00200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P9215_RS00240	COG0768	penicillin binding
P9215_RS00250	COG0426	domain, Protein
P9215_RS00250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P9215_RS00260	COG0426	domain, Protein
P9215_RS00260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P9215_RS00265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P9215_RS00270	COG1166	arginine decarboxylase activity
P9215_RS00275	COG0105	UTP biosynthetic process
P9215_RS00280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P9215_RS00280	COG2022	thiamine diphosphate biosynthetic process
P9215_RS00285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P9215_RS00290	COG0237	dephospho-CoA kinase activity
P9215_RS00295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
P9215_RS00310	COG0116	Belongs to the methyltransferase superfamily
P9215_RS00330	COG1196	nuclear chromosome segregation
P9215_RS00350	COG0439	Biotin carboxylase
P9215_RS00365	COG0515	serine threonine protein kinase
P9215_RS00375	COG4178	(ABC) transporter
P9215_RS00385	COG0537	adenosine 5'-monophosphoramidase activity
P9215_RS00390	COG0242	peptide deformylase activity
P9215_RS00395	COG1073	alpha beta
P9215_RS00400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P9215_RS00405	COG0719	Fe-S assembly protein
P9215_RS00410	COG0396	ATPase activity
P9215_RS00415	COG0719	Fe-S assembly protein
P9215_RS00435	COG0033	Phosphoglucomutase
P9215_RS00440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P9215_RS00450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P9215_RS00455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
P9215_RS00460	COG0175	sulfate reduction
P9215_RS00465	COG1252	NADH dehydrogenase
P9215_RS00470	COG0471	metal ion transport
P9215_RS00470	COG3273	potassium ion transport
P9215_RS00475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P9215_RS00480	COG0569	domain protein
P9215_RS00500	COG0488	(ABC) transporter
P9215_RS00505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P9215_RS00535	COG0483	inositol monophosphate 1-phosphatase activity
P9215_RS00555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
P9215_RS00560	COG4243	Vitamin k epoxide reductase
P9215_RS00565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P9215_RS00595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
P9215_RS00620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
P9215_RS00625	COG1587	Uroporphyrinogen-III synthase
P9215_RS00635	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
P9215_RS00640	COG0316	Belongs to the HesB IscA family
P9215_RS00660	COG1090	epimerase
P9215_RS00670	COG0484	heat shock protein binding
P9215_RS00675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P9215_RS00700	COG0745	RESPONSE REGULATOR receiver
P9215_RS00705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P9215_RS00710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P9215_RS00715	COG2217	Heavy metal translocating P-type atpase
P9215_RS00720	COG3063	Type IV pilus biogenesis stability protein PilW
P9215_RS00725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
P9215_RS00735	COG0416	fatty acid biosynthetic process
P9215_RS00740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P9215_RS00745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
P9215_RS00765	COG0617	tRNA 3'-terminal CCA addition
P9215_RS00775	COG1562	ergosterol biosynthetic process
P9215_RS00780	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
P9215_RS00780	COG0493	'glutamate synthase
P9215_RS00795	COG0583	DNA-binding transcription factor activity
P9215_RS00805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P9215_RS00810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS00820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
P9215_RS00830	COG2197	response regulator
P9215_RS00845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P9215_RS00850	COG0713	ATP synthesis coupled electron transport
P9215_RS00855	COG0839	Belongs to the complex I subunit 6 family
P9215_RS00860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS00865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
P9215_RS00870	COG0372	Belongs to the citrate synthase family
P9215_RS00885	COG0133	tryptophan synthase activity
P9215_RS00890	COG0023	Translation Initiation Factor
P9215_RS00895	COG0529	Catalyzes the synthesis of activated sulfate
P9215_RS00900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
P9215_RS00905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P9215_RS00910	COG0745	RESPONSE REGULATOR receiver
P9215_RS00920	COG0275	rRNA processing
P9215_RS00925	COG0649	NAD binding
P9215_RS00930	COG0824	Thioesterase
P9215_RS00945	COG1575	Belongs to the MenA family. Type 1 subfamily
P9215_RS00955	COG0189	ligase activity
P9215_RS00960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P9215_RS00965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P9215_RS00975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P9215_RS01000	COG0018	arginyl-trna synthetase
P9215_RS01005	COG0157	Belongs to the NadC ModD family
P9215_RS01010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P9215_RS01020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P9215_RS01025	COG4172	Belongs to the ABC transporter superfamily
P9215_RS01030	COG0564	pseudouridine synthase activity
P9215_RS01035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
P9215_RS01040	COG0126	phosphoglycerate kinase activity
P9215_RS01050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P9215_RS01055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P9215_RS01060	COG0167	dihydroorotate dehydrogenase activity
P9215_RS01065	COG0328	RNA-DNA hybrid ribonuclease activity
P9215_RS01070	COG0222	ribosome binding
P9215_RS01075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P9215_RS01080	COG0081	regulation of translation
P9215_RS01085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P9215_RS01090	COG0250	Participates in transcription elongation, termination and antitermination
P9215_RS01095	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
P9215_RS01100	COG0542	response to heat
P9215_RS01105	COG0148	phosphopyruvate hydratase activity
P9215_RS01110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P9215_RS01120	COG0492	ferredoxin-NADP+ reductase activity
P9215_RS01135	COG0659	secondary active sulfate transmembrane transporter activity
P9215_RS01140	COG0113	porphobilinogen synthase activity
P9215_RS01150	COG1193	negative regulation of DNA recombination
P9215_RS01155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
P9215_RS01170	COG0435	Glutathione S-transferase
P9215_RS01175	COG2988	succinylglutamate desuccinylase activity
P9215_RS01185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
P9215_RS01195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9215_RS01200	COG2046	Belongs to the sulfate adenylyltransferase family
P9215_RS01200	COG0529	Catalyzes the synthesis of activated sulfate
P9215_RS01210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P9215_RS01230	COG0540	Belongs to the ATCase OTCase family
P9215_RS01240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P9215_RS01260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
P9215_RS01275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P9215_RS01280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P9215_RS01285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P9215_RS01290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
P9215_RS01295	COG0717	Belongs to the dCTP deaminase family
P9215_RS01305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P9215_RS01310	COG4372	Transposase
P9215_RS01325	COG0193	aminoacyl-tRNA hydrolase activity
P9215_RS01350	COG0066	3-isopropylmalate dehydratase activity
P9215_RS01355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
P9215_RS01360	COG1546	Belongs to the CinA family
P9215_RS01360	COG1058	Belongs to the CinA family
P9215_RS01365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
P9215_RS01385	COG0728	peptidoglycan biosynthetic process
P9215_RS01390	COG1489	DNA binding
P9215_RS01395	COG0004	ammonium transporteR
P9215_RS01400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
P9215_RS01410	COG0138	bifunctional purine biosynthesis protein purh
P9215_RS01425	COG5002	protein histidine kinase activity
P9215_RS01430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
P9215_RS01435	COG0343	queuine tRNA-ribosyltransferase activity
P9215_RS01445	COG0673	inositol 2-dehydrogenase activity
P9215_RS01450	COG1253	flavin adenine dinucleotide binding
P9215_RS01460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P9215_RS01475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P9215_RS01480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
P9215_RS01485	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
P9215_RS01490	COG0131	Imidazoleglycerol-phosphate dehydratase
P9215_RS01495	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P9215_RS01510	COG0415	Belongs to the DNA photolyase family
P9215_RS01520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P9215_RS01525	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
P9215_RS01525	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
P9215_RS01535	COG1127	ABC transporter
P9215_RS01540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
P9215_RS01545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS01550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS01555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS01560	COG1773	rubredoxin
P9215_RS01565	COG4447	cellulose binding
P9215_RS01585	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
P9215_RS01590	COG0709	Synthesizes selenophosphate from selenide and ATP
P9215_RS01595	COG0517	IMP dehydrogenase activity
P9215_RS01595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
P9215_RS01595	COG0617	tRNA 3'-terminal CCA addition
P9215_RS01640	COG1070	Carbohydrate kinase
P9215_RS01645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P9215_RS01650	COG0539	negative regulation of cytoplasmic translation
P9215_RS01655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P9215_RS01675	COG2890	protein-(glutamine-N5) methyltransferase activity
P9215_RS01690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
P9215_RS01695	COG2894	cell division
P9215_RS01700	COG0850	regulation of cytokinetic process
P9215_RS01705	COG1078	dGTPase activity
P9215_RS01710	COG0793	Belongs to the peptidase S41A family
P9215_RS01715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P9215_RS01720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P9215_RS01755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P9215_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
P9215_RS01815	COG1233	COG1233 Phytoene dehydrogenase and related
P9215_RS01840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P9215_RS01850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P9215_RS01905	COG0415	Belongs to the DNA photolyase family
P9215_RS01925	COG0351	phosphomethylpyrimidine kinase
P9215_RS01985	COG0463	Glycosyl transferase, family 2
P9215_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
P9215_RS02025	COG2192	nodulation
P9215_RS02230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
P9215_RS02250	COG1160	GTP binding
P9215_RS02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
P9215_RS02265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
P9215_RS02270	COG1799	cell septum assembly
P9215_RS02275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
P9215_RS02295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
P9215_RS02300	COG0321	lipoyl(octanoyl) transferase activity
P9215_RS02305	COG1022	Amp-dependent synthetase and ligase
P9215_RS02315	COG0508	dehydrogenase complex catalyzes the overall conversion of
P9215_RS02320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
P9215_RS02325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P9215_RS02335	COG0626	cystathionine gamma-synthase activity
P9215_RS02340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P9215_RS02345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
P9215_RS02355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P9215_RS02370	COG2226	methyltransferase
P9215_RS02380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
P9215_RS02385	COG0579	oxidoreductase
P9215_RS02390	COG0481	GTPase activity
P9215_RS02400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P9215_RS02420	COG3046	protein related to deoxyribodipyrimidine photolyase
P9215_RS02425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P9215_RS02425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
P9215_RS02430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P9215_RS02435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P9215_RS02445	COG0107	imidazoleglycerol-phosphate synthase activity
P9215_RS02450	COG2226	methyltransferase
P9215_RS02465	COG1136	(ABC) transporter
P9215_RS02470	COG1007	ATP synthesis coupled electron transport
P9215_RS02475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P9215_RS02490	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
P9215_RS02515	COG1845	cytochrome c oxidase, subunit III
P9215_RS02520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P9215_RS02530	COG1612	heme a metabolic process
P9215_RS02535	COG0109	protoheme IX farnesyltransferase activity
P9215_RS02555	COG0459	protein refolding
P9215_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
P9215_RS02570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
P9215_RS02575	COG1619	proteins homologs of microcin C7 resistance protein MccF
P9215_RS02580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P9215_RS02585	COG0248	Ppx GppA phosphatase
P9215_RS02600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P9215_RS02605	COG3258	Cytochrome c
P9215_RS02610	COG0723	plastoquinol--plastocyanin reductase activity
P9215_RS02620	COG0805	protein transport
P9215_RS02630	COG1293	RNA-binding protein homologous to eukaryotic snRNP
P9215_RS02635	COG0194	GDP metabolic process
P9215_RS02645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
P9215_RS02660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P9215_RS02680	COG0335	large ribosomal subunit rRNA binding
P9215_RS02690	COG0024	Methionine aminopeptidase
P9215_RS02695	COG0300	oxidoreductase activity
P9215_RS02695	COG3000	fatty acid hydroxylase
P9215_RS02700	COG0857	belongs to the CobB CobQ family
P9215_RS02710	COG1666	GTP binding
P9215_RS02725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
P9215_RS02745	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
P9215_RS02760	COG0523	cobalamin synthesis protein
P9215_RS02765	COG2154	pterin-4-alpha-carbinolamine dehydratase
P9215_RS02770	COG0432	Pfam Uncharacterised protein family UPF0047
P9215_RS02775	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
P9215_RS02785	COG0181	hydroxymethylbilane synthase activity
P9215_RS02790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9215_RS02795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P9215_RS02805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P9215_RS02820	COG0629	single-stranded DNA binding
P9215_RS02835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P9215_RS02840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
P9215_RS02850	COG0442	prolyl-tRNA aminoacylation
P9215_RS02865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P9215_RS02870	COG1393	Belongs to the ArsC family
P9215_RS02880	COG0406	alpha-ribazole phosphatase activity
P9215_RS02895	COG0768	penicillin binding
P9215_RS02900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P9215_RS02910	COG0233	cytoplasmic translational termination
P9215_RS02915	COG0528	UMP kinase activity
P9215_RS02925	COG0582	viral genome integration into host DNA
P9215_RS02930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
P9215_RS02935	COG0028	Belongs to the TPP enzyme family
P9215_RS02955	COG0539	negative regulation of cytoplasmic translation
P9215_RS02965	COG3396	Phenylacetate-CoA oxygenase
P9215_RS02970	COG5322	oxidoreductase activity
P9215_RS02975	COG0825	malonyl-CoA metabolic process
P9215_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
P9215_RS02985	COG0302	gtp cyclohydrolase
P9215_RS02990	COG0135	phosphoribosylanthranilate isomerase activity
P9215_RS02995	COG1994	Peptidase M50
P9215_RS02995	COG0517	IMP dehydrogenase activity
P9215_RS03000	COG0095	Lipoate-protein ligase
P9215_RS03020	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
P9215_RS03025	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
P9215_RS03030	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
P9215_RS03040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
P9215_RS03045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
P9215_RS03050	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
P9215_RS03055	COG1850	ribulose-bisphosphate carboxylase activity
P9215_RS03060	COG4451	ribulose bisphosphate carboxylase, small
P9215_RS03095	COG0251	oxidation-reduction process
P9215_RS03100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P9215_RS03105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
P9215_RS03110	COG1132	(ABC) transporter
P9215_RS03115	COG0456	acetyltransferase
P9215_RS03130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
P9215_RS03140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P9215_RS03150	COG0418	dihydroorotase activity
P9215_RS03180	COG0159	tryptophan synthase activity
P9215_RS03205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9215_RS03210	COG0140	phosphoribosyl-ATP diphosphatase activity
P9215_RS03210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
P9215_RS03220	COG0542	response to heat
P9215_RS03225	COG3794	PFAM blue (type 1) copper domain protein
P9215_RS03235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
P9215_RS03240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
P9215_RS03270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
P9215_RS03275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P9215_RS03285	COG0339	signal peptide processing
P9215_RS03290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS03295	COG0083	homoserine kinase activity
P9215_RS03300	COG0837	glucose binding
P9215_RS03305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
P9215_RS03310	COG0180	Tryptophanyl-tRNA synthetase
P9215_RS03330	COG1121	(ABC) transporter
P9215_RS03335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P9215_RS03350	COG0681	Belongs to the peptidase S26 family
P9215_RS03355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
P9215_RS03360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
P9215_RS03365	COG0297	glycogen (starch) synthase activity
P9215_RS03370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
P9215_RS03375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
P9215_RS03380	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
P9215_RS03380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P9215_RS03385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
P9215_RS03390	COG2045	Belongs to the ComB family
P9215_RS03410	COG0142	geranyltranstransferase activity
P9215_RS03415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P9215_RS03425	COG2176	DNA-directed DNA polymerase activity
P9215_RS03435	COG0124	histidyl-tRNA synthetase
P9215_RS03485	COG0300	oxidoreductase activity
P9215_RS03490	COG0644	oxidoreductase
P9215_RS03500	COG0668	transmembrane transport
P9215_RS03505	COG1335	isochorismatase
P9215_RS03510	COG0735	belongs to the Fur family
P9215_RS03540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
P9215_RS03545	COG0659	secondary active sulfate transmembrane transporter activity
P9215_RS03585	COG0346	lactoylglutathione lyase activity
P9215_RS03645	COG4106	trans-aconitate 2-methyltransferase activity
P9215_RS03650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
P9215_RS03660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
P9215_RS03675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P9215_RS03680	COG1836	PFAM Integral membrane protein DUF92
P9215_RS03700	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
P9215_RS03705	COG0436	Aminotransferase
P9215_RS03710	COG1573	uracil-dna glycosylase
P9215_RS03715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
P9215_RS03720	COG0793	Belongs to the peptidase S41A family
P9215_RS03725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
P9215_RS03745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
P9215_RS03750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P9215_RS03890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P9215_RS03905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
P9215_RS03920	COG1201	RNA secondary structure unwinding
P9215_RS03925	COG1793	dna ligase
P9215_RS04010	COG0740	serine-type endopeptidase activity
P9215_RS04015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9215_RS04030	COG0612	Peptidase, M16
P9215_RS04050	COG1136	(ABC) transporter
P9215_RS04055	COG1216	Glycosyl transferase, family 2
P9215_RS04060	COG0052	Belongs to the universal ribosomal protein uS2 family
P9215_RS04065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P9215_RS04075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P9215_RS04080	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
P9215_RS04085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P9215_RS04090	COG0751	glycine-tRNA ligase activity
P9215_RS04095	COG0644	oxidoreductase
P9215_RS04105	COG1217	gtp-binding protein TYPA
P9215_RS04120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P9215_RS04125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
P9215_RS04130	COG1494	fructose-1,6-bisphosphatase
P9215_RS04135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
P9215_RS04140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
P9215_RS04145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
P9215_RS04150	COG0363	glucosamine-6-phosphate deaminase activity
P9215_RS04165	COG0129	dihydroxy-acid dehydratase activity
P9215_RS04175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
P9215_RS04190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P9215_RS04195	COG0047	phosphoribosylformylglycinamidine synthase activity
P9215_RS04200	COG3588	fructose-bisphosphate aldolase
P9215_RS04205	COG0673	inositol 2-dehydrogenase activity
P9215_RS04215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
P9215_RS04220	COG3954	Phosphoribulokinase
P9215_RS04225	COG0473	3-isopropylmalate dehydrogenase activity
P9215_RS04230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P9215_RS04235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
P9215_RS04250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
P9215_RS04270	COG2197	response regulator
P9215_RS04285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P9215_RS04310	COG3842	ATPase activity
P9215_RS04325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P9215_RS04335	COG1119	ATPase activity
P9215_RS04405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
P9215_RS04410	COG0830	nickel cation binding
P9215_RS04415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
P9215_RS04420	COG0829	nickel cation binding
P9215_RS04425	COG0831	urea catabolic process
P9215_RS04430	COG0832	Belongs to the urease beta subunit family
P9215_RS04435	COG0804	urea catabolic process
P9215_RS04440	COG0463	Glycosyl transferase, family 2
P9215_RS04445	COG0366	Alpha amylase catalytic
P9215_RS04450	COG3769	mannosylglycerate metabolic process
P9215_RS04470	COG1968	undecaprenyl-diphosphatase activity
P9215_RS04485	COG1132	(ABC) transporter
P9215_RS04495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P9215_RS04500	COG0505	Belongs to the CarA family
P9215_RS04505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
P9215_RS04510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P9215_RS04520	COG0154	amidase activity
P9215_RS04525	COG0587	DNA-directed DNA polymerase activity
P9215_RS04535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
P9215_RS04540	COG0632	four-way junction helicase activity
P9215_RS04555	COG0358	DNA primase activity
P9215_RS04565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
P9215_RS04570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P9215_RS04575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
P9215_RS04585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P9215_RS04590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
P9215_RS04600	COG0022	dehydrogenase e1 component
P9215_RS04600	COG0508	dehydrogenase complex catalyzes the overall conversion of
P9215_RS04605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P9215_RS04610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P9215_RS04630	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
P9215_RS04635	COG0515	serine threonine protein kinase
P9215_RS04655	COG0174	glutamine synthetase
P9215_RS04660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
P9215_RS04670	COG0076	glutamate decarboxylase activity
P9215_RS04675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P9215_RS04680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
P9215_RS04695	COG0469	pyruvate kinase activity
P9215_RS04715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P9215_RS04720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
P9215_RS04740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P9215_RS04745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
P9215_RS04750	COG0326	Molecular chaperone. Has ATPase activity
P9215_RS04755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
P9215_RS04760	COG0483	inositol monophosphate 1-phosphatase activity
P9215_RS04765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P9215_RS04775	COG0443	Heat shock 70 kDa protein
P9215_RS04780	COG0484	heat shock protein binding
P9215_RS04790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P9215_RS04795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P9215_RS04795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P9215_RS04800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
P9215_RS04810	COG0166	Belongs to the GPI family
P9215_RS04815	COG0495	leucyl-tRNA aminoacylation
P9215_RS04840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
P9215_RS04845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P9215_RS04845	COG0426	domain, Protein
P9215_RS04850	COG0322	excinuclease ABC activity
P9215_RS04870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P9215_RS04875	COG1410	methionine synthase
P9215_RS04875	COG0646	methionine synthase
P9215_RS04910	COG0072	phenylalanine-tRNA ligase activity
P9215_RS04915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P9215_RS04920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P9215_RS04925	COG0557	exoribonuclease II activity
P9215_RS04930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P9215_RS04955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
P9215_RS04965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
P9215_RS04985	COG0450	alkyl hydroperoxide reductase
P9215_RS04995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9215_RS05000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
P9215_RS05020	COG2119	membrane
P9215_RS05030	COG0557	exoribonuclease II activity
P9215_RS05045	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
P9215_RS05050	COG0312	modulator of DNA gyrase
P9215_RS05060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P9215_RS05065	COG0861	Integral membrane protein TerC family
P9215_RS05070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P9215_RS05105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
P9215_RS05110	COG1429	ligase activity, forming nitrogen-metal bonds
P9215_RS05115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P9215_RS05120	COG0149	triose-phosphate isomerase activity
P9215_RS05130	COG1132	(ABC) transporter
P9215_RS05140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
P9215_RS05150	COG0799	negative regulation of ribosome biogenesis
P9215_RS05175	COG4555	ABC transporter
P9215_RS05250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P9215_RS05285	COG3340	Belongs to the peptidase S51 family
P9215_RS05345	COG0308	aminopeptidase N
P9215_RS05365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
P9215_RS05390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P9215_RS05525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P9215_RS05535	COG1121	(ABC) transporter
P9215_RS05545	COG0523	cobalamin synthesis protein
P9215_RS05570	COG2308	Evidence 4 Homologs of previously reported genes of
P9215_RS05590	COG1357	PFAM Pentapeptide repeats (8 copies)
P9215_RS05625	COG0601	transmembrane transport
P9215_RS05640	COG0460	homoserine dehydrogenase
P9215_RS05645	COG2166	iron-sulfur cluster assembly
P9215_RS05655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
P9215_RS05660	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
P9215_RS05665	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
P9215_RS05685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P9215_RS05690	COG3118	belongs to the thioredoxin family
P9215_RS05695	COG0516	GMP reductase activity
P9215_RS05700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P9215_RS05705	COG0644	oxidoreductase
P9215_RS05710	COG1543	Belongs to the glycosyl hydrolase 57 family
P9215_RS05715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P9215_RS05725	COG1480	7TM receptor with intracellular HD hydrolase
P9215_RS05730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P9215_RS05740	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
P9215_RS05745	COG1797	cobyrinic acid a,c-diamide synthase activity
P9215_RS05755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
P9215_RS05760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
P9215_RS05775	COG2205	protein histidine kinase activity
P9215_RS05790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
P9215_RS05795	COG1640	4-alpha-glucanotransferase
P9215_RS05805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P9215_RS05810	COG1982	Orn Lys Arg decarboxylase major
P9215_RS05815	COG0575	Belongs to the CDS family
P9215_RS05825	COG0371	Dehydrogenase
P9215_RS05830	COG0542	response to heat
P9215_RS05840	COG0019	diaminopimelate decarboxylase activity
P9215_RS05845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
P9215_RS05850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P9215_RS05855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P9215_RS05860	COG1054	Belongs to the UPF0176 family
P9215_RS05870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P9215_RS05875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
P9215_RS05885	COG1132	(ABC) transporter
P9215_RS05895	COG0513	Belongs to the DEAD box helicase family
P9215_RS05900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P9215_RS05905	COG1074	ATP-dependent DNA helicase activity
P9215_RS05925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
P9215_RS05940	COG0271	Belongs to the BolA IbaG family
P9215_RS05945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
P9215_RS05955	COG0745	RESPONSE REGULATOR receiver
P9215_RS05965	COG1233	COG1233 Phytoene dehydrogenase and related
P9215_RS05970	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
P9215_RS05995	COG0457	Tetratricopeptide repeat
P9215_RS06010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
P9215_RS06065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P9215_RS06070	COG1053	succinate dehydrogenase
P9215_RS06085	COG0793	Belongs to the peptidase S41A family
P9215_RS06085	COG3409	Peptidoglycan-binding domain 1 protein
P9215_RS06205	COG1187	pseudouridine synthase activity
P9215_RS06215	COG2135	peptidase activity
P9215_RS06315	COG0733	neurotransmitter:sodium symporter activity
P9215_RS06370	COG0012	GTP binding
P9215_RS06380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P9215_RS06380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P9215_RS06385	COG0215	cysteine-tRNA ligase activity
P9215_RS06390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P9215_RS06405	COG1073	alpha beta
P9215_RS06450	COG0702	epimerase
P9215_RS06465	COG0440	acetolactate synthase activity
P9215_RS06470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P9215_RS06490	COG0424	maF-like protein
P9215_RS06495	COG1492	cobalamin metabolic process
P9215_RS06535	COG1840	ABC-type Fe3 transport system, periplasmic component
P9215_RS06540	COG3128	pkhd-type hydroxylase
P9215_RS06555	COG0752	glycyl-tRNA synthetase alpha subunit
P9215_RS06600	COG4095	Psort location CytoplasmicMembrane, score
P9215_RS06620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
P9215_RS06625	COG0438	transferase activity, transferring glycosyl groups
P9215_RS06630	COG0697	spore germination
P9215_RS06635	COG0616	signal peptide processing
P9215_RS06650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
P9215_RS06655	COG0594	ribonuclease P activity
P9215_RS06665	COG0706	membrane insertase activity
P9215_RS06670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9215_RS06675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
P9215_RS06680	COG0750	zinc metalloprotease
P9215_RS06685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
P9215_RS06690	COG1185	polyribonucleotide nucleotidyltransferase activity
P9215_RS06695	COG1218	3'(2'),5'-bisphosphate nucleotidase
P9215_RS06700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
P9215_RS06725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P9215_RS06735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
P9215_RS06760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
P9215_RS06780	COG0469	pyruvate kinase activity
P9215_RS06790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
P9215_RS06800	COG1132	(ABC) transporter
P9215_RS06820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P9215_RS06825	COG2942	2-epimerase
P9215_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
P9215_RS06905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P9215_RS06915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
P9215_RS06925	COG1091	dTDP-4-dehydrorhamnose reductase activity
P9215_RS06985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
P9215_RS07005	COG1132	(ABC) transporter
P9215_RS07010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
P9215_RS07025	COG2226	methyltransferase
P9215_RS07040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
P9215_RS07070	COG2089	acid synthase
P9215_RS07080	COG0367	asparagine synthase
P9215_RS07100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P9215_RS07105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
P9215_RS07110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9215_RS07115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P9215_RS07115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P9215_RS07135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P9215_RS07140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
P9215_RS07145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
P9215_RS07155	COG0196	riboflavin kinase activity
P9215_RS07160	COG0352	thiamine-phosphate diphosphorylase activity
P9215_RS07170	COG1691	(AIR) carboxylase
P9215_RS07180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
P9215_RS07195	COG0336	Belongs to the RNA methyltransferase TrmD family
P9215_RS07200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
P9215_RS07215	COG1702	phosphate starvation-inducible protein PhoH
P9215_RS07220	COG0228	four-way junction DNA binding
P9215_RS07225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P9215_RS07235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
P9215_RS07240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9215_RS07245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P9215_RS07245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P9215_RS07250	COG0482	sulfurtransferase activity
P9215_RS07255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
P9215_RS07280	COG0134	indole-3-glycerol-phosphate synthase activity
P9215_RS07285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P9215_RS07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P9215_RS07295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P9215_RS07300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P9215_RS07305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P9215_RS07310	COG0285	dihydrofolate synthase activity
P9215_RS07330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P9215_RS07335	COG1181	Belongs to the D-alanine--D-alanine ligase family
P9215_RS07350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
P9215_RS07355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
P9215_RS07360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P9215_RS07365	COG4956	integral membrane protein (PIN domain superfamily)
P9215_RS07370	COG0740	serine-type endopeptidase activity
P9215_RS07375	COG0740	serine-type endopeptidase activity
P9215_RS07380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
P9215_RS07385	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
P9215_RS07415	COG0776	regulation of translation
P9215_RS07420	COG1523	belongs to the glycosyl hydrolase 13 family
P9215_RS07430	COG2211	Major facilitator Superfamily
P9215_RS07435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P9215_RS07450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
P9215_RS07455	COG0284	orotidine-5'-phosphate decarboxylase activity
P9215_RS07460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
P9215_RS07475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
P9215_RS07480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P9215_RS07490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P9215_RS07495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P9215_RS07500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
P9215_RS07505	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P9215_RS07510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
P9215_RS07515	COG0151	Belongs to the GarS family
P9215_RS07520	COG5002	protein histidine kinase activity
P9215_RS07525	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
P9215_RS07530	COG4251	negative regulation of phosphorylation
P9215_RS07535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P9215_RS07540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P9215_RS07545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P9215_RS07550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
P9215_RS07555	COG2385	sporulation resulting in formation of a cellular spore
P9215_RS07560	COG1234	tRNA 3'-trailer cleavage
P9215_RS07580	COG2264	protein methyltransferase activity
P9215_RS07585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P9215_RS07625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P9215_RS07630	COG4221	oxidoreductase activity
P9215_RS07640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
P9215_RS07670	COG2081	HI0933 family
P9215_RS07775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
P9215_RS07880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P9215_RS07885	COG1845	cytochrome c oxidase, subunit III
P9215_RS07955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P9215_RS08040	COG0443	Heat shock 70 kDa protein
P9215_RS08045	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
P9215_RS08050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
P9215_RS08060	COG0459	protein refolding
P9215_RS08065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P9215_RS08070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P9215_RS08075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
P9215_RS08085	COG0006	proline dipeptidase activity
P9215_RS08095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P9215_RS08100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
P9215_RS08105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
P9215_RS08105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P9215_RS08110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P9215_RS08125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
P9215_RS08130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
P9215_RS08135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P9215_RS08140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P9215_RS08145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P9215_RS08150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P9215_RS08155	COG0356	it plays a direct role in the translocation of protons across the membrane
P9215_RS08165	COG0772	Belongs to the SEDS family
P9215_RS08170	COG0785	Cytochrome C biogenesis protein
P9215_RS08175	COG1333	cytochrome c biogenesis protein
P9215_RS08180	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
P9215_RS08190	COG0347	Belongs to the P(II) protein family
P9215_RS08195	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
P9215_RS08200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
P9215_RS08205	COG0114	fumarate hydratase activity
P9215_RS08210	COG4581	dead DEAH box helicase
P9215_RS08215	COG0156	8-amino-7-oxononanoate synthase activity
P9215_RS08230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P9215_RS08235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P9215_RS08245	COG0484	heat shock protein binding
P9215_RS08250	COG0357	Ribosomal RNA small subunit methyltransferase G
P9215_RS08280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
P9215_RS08290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P9215_RS08295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P9215_RS08300	COG0085	RNA polymerase activity
P9215_RS08305	COG0084	hydrolase, TatD family'
P9215_RS08310	COG0268	Binds directly to 16S ribosomal RNA
P9215_RS08315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
P9215_RS08320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
P9215_RS08325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P9215_RS08330	COG0779	Required for maturation of 30S ribosomal subunits
P9215_RS08335	COG0195	Participates in both transcription termination and antitermination
P9215_RS08345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
P9215_RS08365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
P9215_RS08370	COG0436	Aminotransferase
P9215_RS08375	COG1530	ribonuclease E activity
P9215_RS08380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P9215_RS08390	COG0077	Prephenate dehydratase
P9215_RS08390	COG1605	Chorismate mutase
P9215_RS08395	COG2226	methyltransferase
P9215_RS08400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P9215_RS08405	COG0051	transcription antitermination factor activity, RNA binding
P9215_RS08410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P9215_RS08415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P9215_RS08420	COG0049	tRNA binding
P9215_RS08425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P9215_RS08430	COG0069	glutamate synthase activity
P9215_RS08430	COG0067	glutamate synthase
P9215_RS08430	COG0070	glutamate synthase
P9215_RS08440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P9215_RS08480	COG0463	Glycosyl transferase, family 2
P9215_RS08485	COG2885	chlorophyll binding
P9215_RS08490	COG2885	chlorophyll binding
P9215_RS08515	COG2192	nodulation
P9215_RS08525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
P9215_RS08535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
P9215_RS08540	COG0254	rRNA binding
P9215_RS08545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P9215_RS08550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P9215_RS08555	COG0101	tRNA pseudouridine synthase activity
P9215_RS08560	COG0203	ribosomal protein L17
P9215_RS08565	COG0202	RNA polymerase activity
P9215_RS08570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P9215_RS08575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P9215_RS08580	COG0563	adenylate kinase activity
P9215_RS08585	COG0201	protein transport
P9215_RS08590	COG0200	Binds to the 23S rRNA
P9215_RS08595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
P9215_RS08600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P9215_RS08605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
P9215_RS08610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P9215_RS08615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P9215_RS08620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
P9215_RS08625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
P9215_RS08630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
P9215_RS08635	COG0255	Belongs to the universal ribosomal protein uL29 family
P9215_RS08640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P9215_RS08645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P9215_RS08650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P9215_RS08655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P9215_RS08660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
P9215_RS08665	COG0089	rRNA binding
P9215_RS08670	COG0088	Forms part of the polypeptide exit tunnel
P9215_RS08675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
P9215_RS08700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
P9215_RS08725	COG3001	Fructosamine kinase
P9215_RS08740	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
P9215_RS08745	COG1606	tRNA processing
P9215_RS08750	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
P9215_RS08755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
P9215_RS08770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
P9215_RS08780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P9215_RS08795	COG0772	Belongs to the SEDS family
P9215_RS08800	COG0489	protein tyrosine kinase activity
P9215_RS08805	COG0408	coproporphyrinogen oxidase activity
P9215_RS08840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P9215_RS08845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
P9215_RS08845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
P9215_RS08850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P9215_RS08865	COG5398	heme oxygenase
P9215_RS08875	COG0538	isocitrate dehydrogenase activity
P9215_RS08895	COG0475	glutathione-regulated potassium exporter activity
P9215_RS08900	COG0058	SHG alpha-glucan phosphorylase activity
P9215_RS08920	COG0571	ribonuclease III activity
P9215_RS08930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
P9215_RS08935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
P9215_RS08940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9215_RS08945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P9215_RS08950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P9215_RS08955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P9215_RS08960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
P9215_RS08970	COG1473	amidohydrolase
P9215_RS08980	COG2255	four-way junction helicase activity
P9215_RS08985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P9215_RS08995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P9215_RS09000	COG0745	RESPONSE REGULATOR receiver
P9215_RS09010	COG1792	Involved in formation and maintenance of cell shape
P9215_RS09020	COG0629	single-stranded DNA binding
P9215_RS09025	COG0586	Pfam SNARE associated Golgi protein
P9215_RS09030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
P9215_RS09035	COG0802	atpase or kinase
P9215_RS09050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9215_RS09055	COG2239	Acts as a magnesium transporter
P9215_RS09065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
P9215_RS09075	COG1372	Participates in initiation and elongation during chromosome replication
P9215_RS09075	COG0187	DNA topoisomerase II activity
P9215_RS09080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P9215_RS09085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P9215_RS09090	COG1725	Transcriptional regulator
P9215_RS09095	COG1045	serine acetyltransferase
P9215_RS09100	COG0653	protein targeting
P9215_RS09120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
P9215_RS09130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
P9215_RS09150	COG0556	nucleotide-excision repair
P9215_RS09160	COG0037	tRNA processing
P9215_RS09165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
P9215_RS09170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P9215_RS09175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P9215_RS09180	COG0544	peptidyl-prolyl cis-trans isomerase activity
P9215_RS09185	COG0740	serine-type endopeptidase activity
P9215_RS09190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
P9215_RS09195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P9215_RS09200	COG1215	transferase activity, transferring glycosyl groups
P9215_RS09205	COG2385	sporulation resulting in formation of a cellular spore
P9215_RS09210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
P9215_RS09215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P9215_RS09225	COG2022	thiamine diphosphate biosynthetic process
P9215_RS09230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
P9215_RS09235	COG0438	transferase activity, transferring glycosyl groups
P9215_RS09235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P9215_RS09245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P9215_RS09245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P9215_RS09250	COG0509	glycine decarboxylation via glycine cleavage system
P9215_RS09255	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
P9215_RS09270	COG0359	binds to the 23S rRNA
P9215_RS09275	COG0305	Participates in initiation and elongation during chromosome replication
P9215_RS09275	COG1372	Participates in initiation and elongation during chromosome replication
P9215_RS09275	COG0305	Participates in initiation and elongation during chromosome replication
P9215_RS09275	COG1372	Participates in initiation and elongation during chromosome replication
P9215_RS09280	COG0445	tRNA wobble uridine modification
P9215_RS09305	COG1793	dna ligase
P9215_RS09310	COG0398	Pfam SNARE associated Golgi protein
P9215_RS09315	COG0525	valine-tRNA ligase activity
P9215_RS09330	COG3956	TIGRFAM MazG family protein
P9215_RS09335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
P9215_RS09340	COG0010	Belongs to the arginase family
P9215_RS09345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
P9215_RS09350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
P9215_RS09355	COG0504	CTP synthase activity
P9215_RS09360	COG0602	queuosine metabolic process
P9215_RS09365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
P9215_RS09370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P9215_RS09380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
P9215_RS09390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
P9215_RS09395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9215_RS09400	COG0170	dolichyl monophosphate biosynthetic process
P9215_RS09405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P9215_RS09410	COG1049	propionate catabolic process, 2-methylcitrate cycle
P9215_RS09420	COG0788	formyltetrahydrofolate deformylase activity
P9215_RS09430	COG0443	Heat shock 70 kDa protein
P9215_RS09435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
P9215_RS09440	COG0360	Binds together with S18 to 16S ribosomal RNA
P9215_RS09445	COG0137	argininosuccinate synthase activity
P9215_RS09460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P9215_RS09470	COG0438	transferase activity, transferring glycosyl groups
P9215_RS09475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
P9215_RS09480	COG0497	DNA recombination
P9215_RS09485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P9215_RS09495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
P9215_RS09535	COG2094	Belongs to the DNA glycosylase MPG family
P9215_RS09540	COG0500	methyltransferase