locus-tag	class	description
AKG35_RS00005	COG0592	DNA-directed DNA polymerase activity
AKG35_RS00015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKG35_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKG35_RS00035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKG35_RS00050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKG35_RS00055	COG0552	protein localization to endoplasmic reticulum
AKG35_RS00060	COG2208	phosphoserine phosphatase activity
AKG35_RS00065	COG0165	Argininosuccinate lyase
AKG35_RS00070	COG0724	RNA recognition motif
AKG35_RS00075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKG35_RS00080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKG35_RS00085	COG2081	HI0933 family
AKG35_RS00090	COG1459	type II secretion system
AKG35_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKG35_RS00105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKG35_RS00110	COG0484	heat shock protein binding
AKG35_RS00120	COG1162	GTPase activity
AKG35_RS00125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKG35_RS00130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKG35_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKG35_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKG35_RS00145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKG35_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKG35_RS00155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKG35_RS00160	COG0511	ligase activity, forming carbon-carbon bonds
AKG35_RS00165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKG35_RS00190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKG35_RS00235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AKG35_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
AKG35_RS00240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKG35_RS00255	COG0768	penicillin binding
AKG35_RS00275	COG2022	thiamine diphosphate biosynthetic process
AKG35_RS00295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKG35_RS00310	COG1215	transferase activity, transferring glycosyl groups
AKG35_RS00315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKG35_RS00325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKG35_RS00330	COG0740	serine-type endopeptidase activity
AKG35_RS00335	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKG35_RS00345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKG35_RS00350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKG35_RS00360	COG0037	tRNA processing
AKG35_RS00375	COG0556	nucleotide-excision repair
AKG35_RS00395	COG2082	Precorrin-8x methylmutase
AKG35_RS00400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKG35_RS00415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKG35_RS00425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKG35_RS00440	COG0653	protein targeting
AKG35_RS00465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKG35_RS00465	COG2755	lipolytic protein G-D-S-L family
AKG35_RS00495	COG1086	Polysaccharide biosynthesis protein
AKG35_RS00515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKG35_RS00520	COG0107	imidazoleglycerol-phosphate synthase activity
AKG35_RS00530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKG35_RS00540	COG2089	acid synthase
AKG35_RS00545	COG1216	Glycosyl transferase, family 2
AKG35_RS00545	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS00565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKG35_RS00580	COG1088	dTDP-glucose 4,6-dehydratase activity
AKG35_RS00585	COG1045	serine acetyltransferase
AKG35_RS00590	COG1725	Transcriptional regulator
AKG35_RS00595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKG35_RS00600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKG35_RS00605	COG1372	Participates in initiation and elongation during chromosome replication
AKG35_RS00605	COG0187	DNA topoisomerase II activity
AKG35_RS00615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKG35_RS00620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKG35_RS00625	COG0386	Belongs to the glutathione peroxidase family
AKG35_RS00630	COG2239	Acts as a magnesium transporter
AKG35_RS00635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS00645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKG35_RS00660	COG1053	succinate dehydrogenase
AKG35_RS00685	COG0802	atpase or kinase
AKG35_RS00690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKG35_RS00700	COG0586	Pfam SNARE associated Golgi protein
AKG35_RS00705	COG0629	single-stranded DNA binding
AKG35_RS00730	COG0745	RESPONSE REGULATOR receiver
AKG35_RS00735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKG35_RS00755	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AKG35_RS00760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKG35_RS00770	COG0515	serine threonine protein kinase
AKG35_RS00770	COG1357	PFAM Pentapeptide repeats (8 copies)
AKG35_RS00775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKG35_RS00780	COG2255	four-way junction helicase activity
AKG35_RS00790	COG1473	amidohydrolase
AKG35_RS00800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKG35_RS00820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKG35_RS00860	COG1032	radical SAM domain protein
AKG35_RS00875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKG35_RS00880	COG4243	Vitamin k epoxide reductase
AKG35_RS00885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKG35_RS00890	COG1555	photosystem II stabilization
AKG35_RS00900	COG1968	undecaprenyl-diphosphatase activity
AKG35_RS00950	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKG35_RS00955	COG0235	Class ii aldolase
AKG35_RS00960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKG35_RS00975	COG0514	ATP-dependent DNA helicase (RecQ)
AKG35_RS00980	COG3942	CHAP domain
AKG35_RS00980	COG1388	LysM domain
AKG35_RS00985	COG1012	belongs to the aldehyde dehydrogenase family
AKG35_RS00995	COG1115	amino acid carrier protein
AKG35_RS01025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKG35_RS01035	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AKG35_RS01050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKG35_RS01070	COG1160	GTP binding
AKG35_RS01075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKG35_RS01085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKG35_RS01090	COG1799	cell septum assembly
AKG35_RS01095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKG35_RS01100	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS01110	COG1381	Involved in DNA repair and RecF pathway recombination
AKG35_RS01115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKG35_RS01120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKG35_RS01125	COG0321	lipoyl(octanoyl) transferase activity
AKG35_RS01130	COG1022	Amp-dependent synthetase and ligase
AKG35_RS01140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKG35_RS01160	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKG35_RS01170	COG0531	amino acid
AKG35_RS01185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKG35_RS01190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKG35_RS01200	COG0626	cystathionine gamma-synthase activity
AKG35_RS01220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKG35_RS01240	COG4974	Belongs to the 'phage' integrase family
AKG35_RS01335	COG1704	LemA family
AKG35_RS01345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKG35_RS01350	COG0579	oxidoreductase
AKG35_RS01365	COG0481	GTPase activity
AKG35_RS01410	COG5002	protein histidine kinase activity
AKG35_RS01425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKG35_RS01430	COG3695	enzyme binding
AKG35_RS01435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKG35_RS01435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKG35_RS01440	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AKG35_RS01445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKG35_RS01455	COG0107	imidazoleglycerol-phosphate synthase activity
AKG35_RS01495	COG0752	glycyl-tRNA synthetase alpha subunit
AKG35_RS01500	COG3659	wide pore channel activity
AKG35_RS01510	COG3128	pkhd-type hydroxylase
AKG35_RS01515	COG1840	ABC-type Fe3 transport system, periplasmic component
AKG35_RS01655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKG35_RS01665	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AKG35_RS01670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKG35_RS01675	COG0740	serine-type endopeptidase activity
AKG35_RS01680	COG0740	serine-type endopeptidase activity
AKG35_RS01685	COG4956	integral membrane protein (PIN domain superfamily)
AKG35_RS01690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKG35_RS01705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKG35_RS01720	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKG35_RS01725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKG35_RS01760	COG0285	dihydrofolate synthase activity
AKG35_RS01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKG35_RS01770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKG35_RS01785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKG35_RS01790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKG35_RS01795	COG0134	indole-3-glycerol-phosphate synthase activity
AKG35_RS01830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKG35_RS01835	COG0482	sulfurtransferase activity
AKG35_RS01840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKG35_RS01840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKG35_RS01845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS01850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKG35_RS01860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKG35_RS01870	COG1702	phosphate starvation-inducible protein PhoH
AKG35_RS01875	COG0670	Belongs to the BI1 family
AKG35_RS01900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKG35_RS01905	COG0336	Belongs to the RNA methyltransferase TrmD family
AKG35_RS01915	COG1691	(AIR) carboxylase
AKG35_RS01930	COG0352	thiamine-phosphate diphosphorylase activity
AKG35_RS01940	COG0196	riboflavin kinase activity
AKG35_RS01950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKG35_RS01955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKG35_RS01960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKG35_RS01995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKG35_RS01995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKG35_RS02005	COG2135	peptidase activity
AKG35_RS02015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKG35_RS02020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKG35_RS02025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKG35_RS02055	COG0242	peptide deformylase activity
AKG35_RS02065	COG2176	DNA-directed DNA polymerase activity
AKG35_RS02070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKG35_RS02080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKG35_RS02090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKG35_RS02095	COG0142	geranyltranstransferase activity
AKG35_RS02100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKG35_RS02115	COG2045	Belongs to the ComB family
AKG35_RS02120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKG35_RS02125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKG35_RS02135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKG35_RS02140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKG35_RS02150	COG0297	glycogen (starch) synthase activity
AKG35_RS02155	COG1376	ErfK ybiS ycfS ynhG family protein
AKG35_RS02160	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKG35_RS02165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKG35_RS02170	COG0681	Belongs to the peptidase S26 family
AKG35_RS02200	COG0644	oxidoreductase
AKG35_RS02205	COG2226	methyltransferase
AKG35_RS02215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKG35_RS02220	COG1121	(ABC) transporter
AKG35_RS02245	COG0180	Tryptophanyl-tRNA synthetase
AKG35_RS02255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKG35_RS02260	COG0837	glucose binding
AKG35_RS02265	COG0083	homoserine kinase activity
AKG35_RS02270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS02275	COG0339	signal peptide processing
AKG35_RS02320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKG35_RS02360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKG35_RS02365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKG35_RS02375	COG3794	PFAM blue (type 1) copper domain protein
AKG35_RS02380	COG0542	response to heat
AKG35_RS02395	COG0140	phosphoribosyl-ATP diphosphatase activity
AKG35_RS02395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKG35_RS02410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS02455	COG0159	tryptophan synthase activity
AKG35_RS02475	COG0418	dihydroorotase activity
AKG35_RS02485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKG35_RS02505	COG0076	glutamate decarboxylase activity
AKG35_RS02540	COG4221	oxidoreductase activity
AKG35_RS02600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKG35_RS02615	COG1528	Iron-storage protein
AKG35_RS02625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKG35_RS02640	COG3842	ATPase activity
AKG35_RS02655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKG35_RS02685	COG2010	Cytochrome c
AKG35_RS02700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKG35_RS02715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKG35_RS02725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKG35_RS02725	COG0617	tRNA 3'-terminal CCA addition
AKG35_RS02725	COG0517	IMP dehydrogenase activity
AKG35_RS02740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKG35_RS02750	COG2197	response regulator
AKG35_RS02755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKG35_RS02770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKG35_RS02785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKG35_RS02790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKG35_RS02795	COG0473	3-isopropylmalate dehydrogenase activity
AKG35_RS02800	COG3954	Phosphoribulokinase
AKG35_RS02805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKG35_RS02820	COG0673	inositol 2-dehydrogenase activity
AKG35_RS02825	COG0191	fructose-bisphosphate aldolase activity
AKG35_RS02830	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKG35_RS02835	COG0047	phosphoribosylformylglycinamidine synthase activity
AKG35_RS02840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKG35_RS02845	COG0674	pyruvate-flavodoxin oxidoreductase activity
AKG35_RS02845	COG1013	pyruvate-flavodoxin oxidoreductase activity
AKG35_RS02845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AKG35_RS02845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKG35_RS02905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AKG35_RS02910	COG2226	methyltransferase
AKG35_RS02915	COG4175	Glycine betaine
AKG35_RS02920	COG4176	ABC-type proline glycine betaine transport system permease component
AKG35_RS02925	COG2113	Glycine betaine
AKG35_RS02940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKG35_RS02950	COG0129	dihydroxy-acid dehydratase activity
AKG35_RS02970	COG0363	glucosamine-6-phosphate deaminase activity
AKG35_RS02975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKG35_RS02980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AKG35_RS02985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKG35_RS02990	COG1494	fructose-1,6-bisphosphatase
AKG35_RS02995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKG35_RS03000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKG35_RS03010	COG1137	ATPase activity
AKG35_RS03025	COG1217	gtp-binding protein TYPA
AKG35_RS03035	COG0644	oxidoreductase
AKG35_RS03040	COG0751	glycine-tRNA ligase activity
AKG35_RS03045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKG35_RS03050	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AKG35_RS03055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKG35_RS03065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKG35_RS03070	COG0052	Belongs to the universal ribosomal protein uS2 family
AKG35_RS03100	COG0612	Peptidase, M16
AKG35_RS03120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKG35_RS03140	COG0590	tRNA wobble adenosine to inosine editing
AKG35_RS03140	COG0037	tRNA processing
AKG35_RS03145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKG35_RS03150	COG0174	glutamine synthetase
AKG35_RS03165	COG0628	permease
AKG35_RS03175	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AKG35_RS03180	COG0515	serine threonine protein kinase
AKG35_RS03210	COG2226	methyltransferase
AKG35_RS03230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKG35_RS03235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKG35_RS03240	COG0022	dehydrogenase e1 component
AKG35_RS03240	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKG35_RS03250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKG35_RS03255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKG35_RS03270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKG35_RS03275	COG0792	nuclease activity
AKG35_RS03315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKG35_RS03330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKG35_RS03355	COG0358	DNA primase activity
AKG35_RS03375	COG0632	four-way junction helicase activity
AKG35_RS03390	COG0587	DNA-directed DNA polymerase activity
AKG35_RS03395	COG0154	amidase activity
AKG35_RS03405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKG35_RS03410	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AKG35_RS03415	COG1366	Belongs to the anti-sigma-factor antagonist family
AKG35_RS03420	COG0505	Belongs to the CarA family
AKG35_RS03425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKG35_RS03430	COG1132	(ABC) transporter
AKG35_RS03445	COG1119	ATPase activity
AKG35_RS03460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKG35_RS03490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKG35_RS03495	COG1175	transmembrane transport
AKG35_RS03500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKG35_RS03515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKG35_RS03530	COG0740	serine-type endopeptidase activity
AKG35_RS03535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKG35_RS03540	COG1136	(ABC) transporter
AKG35_RS03540	COG0577	efflux transmembrane transporter activity
AKG35_RS03545	COG0469	pyruvate kinase activity
AKG35_RS03560	COG0762	integral membrane protein
AKG35_RS03570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKG35_RS03575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKG35_RS03615	COG1175	transmembrane transport
AKG35_RS03620	COG1653	transport
AKG35_RS03630	COG0326	Molecular chaperone. Has ATPase activity
AKG35_RS03640	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKG35_RS03645	COG0483	inositol monophosphate 1-phosphatase activity
AKG35_RS03655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKG35_RS03660	COG0581	inorganic phosphate transmembrane transporter activity
AKG35_RS03665	COG0573	inorganic phosphate transmembrane transporter activity
AKG35_RS03670	COG0443	Heat shock 70 kDa protein
AKG35_RS03675	COG0484	heat shock protein binding
AKG35_RS03685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AKG35_RS03690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKG35_RS03695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKG35_RS03695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKG35_RS03700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKG35_RS03705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKG35_RS03725	COG0166	Belongs to the GPI family
AKG35_RS03730	COG0495	leucyl-tRNA aminoacylation
AKG35_RS03740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKG35_RS03745	COG1104	cysteine desulfurase activity
AKG35_RS03770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKG35_RS03775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKG35_RS03775	COG0426	domain, Protein
AKG35_RS03780	COG0322	excinuclease ABC activity
AKG35_RS03785	COG1981	membrane
AKG35_RS03800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKG35_RS03805	COG1410	methionine synthase
AKG35_RS03805	COG0646	methionine synthase
AKG35_RS03815	COG2385	sporulation resulting in formation of a cellular spore
AKG35_RS03845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKG35_RS03850	COG0072	phenylalanine-tRNA ligase activity
AKG35_RS03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKG35_RS03860	COG0557	exoribonuclease II activity
AKG35_RS03870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKG35_RS03905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKG35_RS03910	COG0739	heme binding
AKG35_RS03920	COG0739	heme binding
AKG35_RS03930	COG0450	alkyl hydroperoxide reductase
AKG35_RS03935	COG1615	UPF0182 protein
AKG35_RS03940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKG35_RS03955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKG35_RS03960	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKG35_RS03960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKG35_RS03965	COG0038	chloride channel
AKG35_RS03975	COG2119	membrane
AKG35_RS03985	COG0557	exoribonuclease II activity
AKG35_RS03990	COG0163	prenyltransferase activity
AKG35_RS04005	COG0312	modulator of DNA gyrase
AKG35_RS04015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKG35_RS04035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKG35_RS04040	COG0793	Belongs to the peptidase S41A family
AKG35_RS04045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKG35_RS04050	COG1573	uracil-dna glycosylase
AKG35_RS04055	COG0436	Aminotransferase
AKG35_RS04060	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AKG35_RS04080	COG1191	sigma factor activity
AKG35_RS04085	COG1836	PFAM Integral membrane protein DUF92
AKG35_RS04105	COG1122	ATPase activity
AKG35_RS04120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AKG35_RS04160	COG0519	Catalyzes the synthesis of GMP from XMP
AKG35_RS04160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKG35_RS04170	COG0716	FMN binding
AKG35_RS04175	COG3659	wide pore channel activity
AKG35_RS04185	COG2205	protein histidine kinase activity
AKG35_RS04215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKG35_RS04225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKG35_RS04235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKG35_RS04240	COG1429	ligase activity, forming nitrogen-metal bonds
AKG35_RS04245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKG35_RS04250	COG0149	triose-phosphate isomerase activity
AKG35_RS04260	COG1132	(ABC) transporter
AKG35_RS04275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKG35_RS04285	COG0799	negative regulation of ribosome biogenesis
AKG35_RS04435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKG35_RS04480	COG1970	mechanosensitive ion channel activity
AKG35_RS04495	COG0735	belongs to the Fur family
AKG35_RS04510	COG1799	cell septum assembly
AKG35_RS04535	COG0420	3'-5' exonuclease activity
AKG35_RS04540	COG2197	response regulator
AKG35_RS04570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKG35_RS04585	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AKG35_RS04675	COG1126	abc transporter atp-binding protein
AKG35_RS04680	COG0765	amino acid transport
AKG35_RS04695	COG4597	amino acid ABC transporter
AKG35_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKG35_RS04710	COG0659	secondary active sulfate transmembrane transporter activity
AKG35_RS05065	COG2720	vancomycin resistance protein
AKG35_RS05200	COG2274	protein secretion by the type I secretion system
AKG35_RS05295	COG0745	RESPONSE REGULATOR receiver
AKG35_RS05305	COG2205	protein histidine kinase activity
AKG35_RS05310	COG3659	wide pore channel activity
AKG35_RS05320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKG35_RS05325	COG0640	Transcriptional regulator
AKG35_RS05385	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKG35_RS05390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKG35_RS05410	COG2226	methyltransferase
AKG35_RS05465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKG35_RS05470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AKG35_RS05480	COG1051	belongs to the nudix hydrolase family
AKG35_RS05520	COG0412	Dienelactone hydrolase
AKG35_RS05595	COG0477	Major facilitator Superfamily
AKG35_RS05655	COG0308	aminopeptidase N
AKG35_RS05675	COG1054	Belongs to the UPF0176 family
AKG35_RS05680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKG35_RS05685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKG35_RS05690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKG35_RS05695	COG0019	diaminopimelate decarboxylase activity
AKG35_RS05705	COG0542	response to heat
AKG35_RS05710	COG0371	Dehydrogenase
AKG35_RS05715	COG2267	carboxylic ester hydrolase activity
AKG35_RS05725	COG0575	Belongs to the CDS family
AKG35_RS05730	COG1982	Orn Lys Arg decarboxylase major
AKG35_RS05735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKG35_RS05740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS05745	COG1187	pseudouridine synthase activity
AKG35_RS05755	COG1640	4-alpha-glucanotransferase
AKG35_RS05770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKG35_RS05780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKG35_RS05785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKG35_RS05800	COG1132	(ABC) transporter
AKG35_RS05810	COG0724	RNA recognition motif
AKG35_RS05820	COG0513	Belongs to the DEAD box helicase family
AKG35_RS05830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKG35_RS05835	COG1074	ATP-dependent DNA helicase activity
AKG35_RS05850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKG35_RS05855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKG35_RS05860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKG35_RS05875	COG0271	Belongs to the BolA IbaG family
AKG35_RS05880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKG35_RS05890	COG0745	RESPONSE REGULATOR receiver
AKG35_RS05900	COG2205	protein histidine kinase activity
AKG35_RS05920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKG35_RS05925	COG3429	Glucose-6-phosphate dehydrogenase subunit
AKG35_RS05925	COG3409	Peptidoglycan-binding domain 1 protein
AKG35_RS05930	COG1797	cobyrinic acid a,c-diamide synthase activity
AKG35_RS05945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKG35_RS05955	COG0142	geranyltranstransferase activity
AKG35_RS05960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKG35_RS05965	COG1480	7TM receptor with intracellular HD hydrolase
AKG35_RS05970	COG0564	pseudouridine synthase activity
AKG35_RS06015	COG0395	ABC-type sugar transport system, permease component
AKG35_RS06020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKG35_RS06025	COG1543	Belongs to the glycosyl hydrolase 57 family
AKG35_RS06030	COG0644	oxidoreductase
AKG35_RS06035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKG35_RS06045	COG0516	GMP reductase activity
AKG35_RS06050	COG3118	belongs to the thioredoxin family
AKG35_RS06055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKG35_RS06065	COG2010	Cytochrome c
AKG35_RS06085	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AKG35_RS06090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKG35_RS06095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKG35_RS06100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKG35_RS06120	COG2166	iron-sulfur cluster assembly
AKG35_RS06125	COG0460	homoserine dehydrogenase
AKG35_RS06140	COG0601	transmembrane transport
AKG35_RS06160	COG3659	wide pore channel activity
AKG35_RS06190	COG0012	GTP binding
AKG35_RS06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKG35_RS06200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKG35_RS06200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKG35_RS06210	COG0215	cysteine-tRNA ligase activity
AKG35_RS06215	COG0733	neurotransmitter:sodium symporter activity
AKG35_RS06220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKG35_RS06225	COG3411	Ferredoxin
AKG35_RS06265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKG35_RS06275	COG2226	methyltransferase
AKG35_RS06300	COG2267	carboxylic ester hydrolase activity
AKG35_RS06305	COG0440	acetolactate synthase activity
AKG35_RS06310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKG35_RS06330	COG0424	maF-like protein
AKG35_RS06340	COG1492	cobalamin metabolic process
AKG35_RS06355	COG0678	peroxiredoxin activity
AKG35_RS06360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKG35_RS06365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKG35_RS06380	COG0456	acetyltransferase
AKG35_RS06385	COG1132	(ABC) transporter
AKG35_RS06390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKG35_RS06395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKG35_RS06400	COG0251	oxidation-reduction process
AKG35_RS06420	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AKG35_RS06445	COG4451	ribulose bisphosphate carboxylase, small
AKG35_RS06450	COG1850	ribulose-bisphosphate carboxylase activity
AKG35_RS06455	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AKG35_RS06460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKG35_RS06465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AKG35_RS06495	COG0659	secondary active sulfate transmembrane transporter activity
AKG35_RS06500	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AKG35_RS06505	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AKG35_RS06510	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AKG35_RS06535	COG0730	response to heat
AKG35_RS06545	COG0095	Lipoate-protein ligase
AKG35_RS06550	COG1994	Peptidase M50
AKG35_RS06550	COG0517	IMP dehydrogenase activity
AKG35_RS06555	COG0135	phosphoribosylanthranilate isomerase activity
AKG35_RS06560	COG0302	gtp cyclohydrolase
AKG35_RS06570	COG0825	malonyl-CoA metabolic process
AKG35_RS06575	COG5322	oxidoreductase activity
AKG35_RS06580	COG3396	Phenylacetate-CoA oxygenase
AKG35_RS06590	COG0539	negative regulation of cytoplasmic translation
AKG35_RS06600	COG1496	oxidoreductase activity
AKG35_RS06605	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AKG35_RS06620	COG0028	Belongs to the TPP enzyme family
AKG35_RS06625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKG35_RS06635	COG2226	methyltransferase
AKG35_RS06645	COG0528	UMP kinase activity
AKG35_RS06650	COG0233	cytoplasmic translational termination
AKG35_RS06655	COG0644	oxidoreductase
AKG35_RS06665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKG35_RS06670	COG0768	penicillin binding
AKG35_RS06710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AKG35_RS06720	COG0442	prolyl-tRNA aminoacylation
AKG35_RS06730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKG35_RS06735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKG35_RS06750	COG0629	single-stranded DNA binding
AKG35_RS06765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKG35_RS06780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKG35_RS06785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS06790	COG0181	hydroxymethylbilane synthase activity
AKG35_RS06800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AKG35_RS06820	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AKG35_RS06830	COG0432	Pfam Uncharacterised protein family UPF0047
AKG35_RS06840	COG2154	pterin-4-alpha-carbinolamine dehydratase
AKG35_RS06845	COG0523	cobalamin synthesis protein
AKG35_RS06870	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AKG35_RS06890	COG0708	Exodeoxyribonuclease III
AKG35_RS06895	COG0277	FAD linked oxidase domain protein
AKG35_RS06900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKG35_RS06905	COG0154	amidase activity
AKG35_RS06910	COG1666	GTP binding
AKG35_RS06920	COG0330	HflC and HflK could
AKG35_RS06935	COG0857	belongs to the CobB CobQ family
AKG35_RS06945	COG3000	fatty acid hydroxylase
AKG35_RS06945	COG0300	oxidoreductase activity
AKG35_RS06950	COG0024	Methionine aminopeptidase
AKG35_RS06955	COG0335	large ribosomal subunit rRNA binding
AKG35_RS06975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKG35_RS06995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKG35_RS07010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKG35_RS07025	COG0194	GDP metabolic process
AKG35_RS07030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AKG35_RS07035	COG0805	protein transport
AKG35_RS07045	COG3258	Cytochrome c
AKG35_RS07050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKG35_RS07070	COG0248	Ppx GppA phosphatase
AKG35_RS07075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKG35_RS07080	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKG35_RS07095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKG35_RS07105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKG35_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
AKG35_RS07115	COG0459	protein refolding
AKG35_RS07120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AKG35_RS07140	COG0109	protoheme IX farnesyltransferase activity
AKG35_RS07145	COG1612	heme a metabolic process
AKG35_RS07155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKG35_RS07160	COG1845	cytochrome c oxidase, subunit III
AKG35_RS07195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AKG35_RS07210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKG35_RS07215	COG1007	ATP synthesis coupled electron transport
AKG35_RS07220	COG1136	(ABC) transporter
AKG35_RS07230	COG0745	RESPONSE REGULATOR receiver
AKG35_RS07235	COG0739	heme binding
AKG35_RS07240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKG35_RS07240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKG35_RS07245	COG0436	Aminotransferase
AKG35_RS07250	COG1842	Phage shock protein A
AKG35_RS07265	COG0697	spore germination
AKG35_RS07270	COG0616	signal peptide processing
AKG35_RS07285	COG0594	ribonuclease P activity
AKG35_RS07295	COG0706	membrane insertase activity
AKG35_RS07305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKG35_RS07310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKG35_RS07315	COG0750	zinc metalloprotease
AKG35_RS07320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKG35_RS07325	COG1185	polyribonucleotide nucleotidyltransferase activity
AKG35_RS07330	COG1218	3'(2'),5'-bisphosphate nucleotidase
AKG35_RS07335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKG35_RS07430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKG35_RS07435	COG0776	regulation of translation
AKG35_RS07455	COG2211	Major facilitator Superfamily
AKG35_RS07460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKG35_RS07470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKG35_RS07475	COG0284	orotidine-5'-phosphate decarboxylase activity
AKG35_RS07480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKG35_RS07490	COG2197	response regulator
AKG35_RS07500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKG35_RS07515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKG35_RS07520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKG35_RS07525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKG35_RS07530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKG35_RS07535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKG35_RS07545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKG35_RS07555	COG0151	Belongs to the GarS family
AKG35_RS07560	COG5002	protein histidine kinase activity
AKG35_RS07565	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AKG35_RS07570	COG4251	negative regulation of phosphorylation
AKG35_RS07580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKG35_RS07585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKG35_RS07590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKG35_RS07595	COG0217	transcriptional regulatory protein
AKG35_RS07600	COG0363	glucosamine-6-phosphate deaminase activity
AKG35_RS07605	COG2385	sporulation resulting in formation of a cellular spore
AKG35_RS07605	COG2247	cell wall binding repeat
AKG35_RS07610	COG1234	tRNA 3'-trailer cleavage
AKG35_RS07615	COG2010	Cytochrome c
AKG35_RS07630	COG2264	protein methyltransferase activity
AKG35_RS07635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKG35_RS07655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKG35_RS07705	COG0443	Heat shock 70 kDa protein
AKG35_RS07710	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKG35_RS07715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKG35_RS07735	COG0459	protein refolding
AKG35_RS07740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKG35_RS07745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKG35_RS07750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKG35_RS07775	COG0006	proline dipeptidase activity
AKG35_RS07785	COG1253	flavin adenine dinucleotide binding
AKG35_RS07790	COG1160	GTP binding
AKG35_RS07795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKG35_RS07800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKG35_RS07800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKG35_RS07810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKG35_RS07820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKG35_RS07825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKG35_RS07835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKG35_RS07840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKG35_RS07850	COG0356	it plays a direct role in the translocation of protons across the membrane
AKG35_RS07860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKG35_RS07865	COG0772	Belongs to the SEDS family
AKG35_RS07875	COG1333	cytochrome c biogenesis protein
AKG35_RS07880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKG35_RS07895	COG0347	Belongs to the P(II) protein family
AKG35_RS07910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKG35_RS07915	COG0114	fumarate hydratase activity
AKG35_RS07920	COG2271	Major facilitator Superfamily
AKG35_RS07925	COG4581	dead DEAH box helicase
AKG35_RS07930	COG0156	8-amino-7-oxononanoate synthase activity
AKG35_RS07945	COG4106	trans-aconitate 2-methyltransferase activity
AKG35_RS07945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AKG35_RS07960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKG35_RS07975	COG0357	Ribosomal RNA small subunit methyltransferase G
AKG35_RS08010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKG35_RS08020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKG35_RS08025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKG35_RS08030	COG0085	RNA polymerase activity
AKG35_RS08035	COG0084	hydrolase, TatD family'
AKG35_RS08040	COG0268	Binds directly to 16S ribosomal RNA
AKG35_RS08045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKG35_RS08050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKG35_RS08055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKG35_RS08070	COG3119	arylsulfatase activity
AKG35_RS08075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKG35_RS08095	COG0641	radical SAM
AKG35_RS08120	COG0779	Required for maturation of 30S ribosomal subunits
AKG35_RS08125	COG0195	Participates in both transcription termination and antitermination
AKG35_RS08135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKG35_RS08135	COG3266	domain, Protein
AKG35_RS08180	COG2988	succinylglutamate desuccinylase activity
AKG35_RS08185	COG0435	Glutathione S-transferase
AKG35_RS08195	COG0488	(ABC) transporter
AKG35_RS08215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKG35_RS08220	COG3842	ATPase activity
AKG35_RS08225	COG1193	negative regulation of DNA recombination
AKG35_RS08230	COG0113	porphobilinogen synthase activity
AKG35_RS08235	COG0484	heat shock protein binding
AKG35_RS08245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AKG35_RS08250	COG0492	ferredoxin-NADP+ reductase activity
AKG35_RS08275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKG35_RS08290	COG0493	'glutamate synthase
AKG35_RS08350	COG2124	cytochrome p450
AKG35_RS08370	COG0671	phosphoesterase, PA-phosphatase related
AKG35_RS08405	COG1136	(ABC) transporter
AKG35_RS08405	COG0577	efflux transmembrane transporter activity
AKG35_RS08415	COG0116	Belongs to the methyltransferase superfamily
AKG35_RS08445	COG1196	nuclear chromosome segregation
AKG35_RS08455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKG35_RS08470	COG0439	Biotin carboxylase
AKG35_RS08485	COG0515	serine threonine protein kinase
AKG35_RS08505	COG4178	(ABC) transporter
AKG35_RS08510	COG0537	adenosine 5'-monophosphoramidase activity
AKG35_RS08530	COG0242	peptide deformylase activity
AKG35_RS08540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKG35_RS08545	COG0719	Fe-S assembly protein
AKG35_RS08550	COG0396	ATPase activity
AKG35_RS08555	COG0719	Fe-S assembly protein
AKG35_RS08580	COG2094	Belongs to the DNA glycosylase MPG family
AKG35_RS08605	COG0033	Phosphoglucomutase
AKG35_RS08625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKG35_RS08645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKG35_RS08650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKG35_RS08655	COG0175	sulfate reduction
AKG35_RS08660	COG1252	NADH dehydrogenase
AKG35_RS08665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKG35_RS08670	COG0471	metal ion transport
AKG35_RS08670	COG3273	potassium ion transport
AKG35_RS08675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKG35_RS08680	COG0569	domain protein
AKG35_RS08685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKG35_RS08710	COG0488	(ABC) transporter
AKG35_RS08715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKG35_RS08730	COG1643	Atp-dependent helicase
AKG35_RS08745	COG1570	exodeoxyribonuclease VII activity
AKG35_RS08750	COG1722	exodeoxyribonuclease VII activity
AKG35_RS08820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKG35_RS08830	COG0793	Belongs to the peptidase S41A family
AKG35_RS08835	COG1078	dGTPase activity
AKG35_RS08840	COG0850	regulation of cytokinetic process
AKG35_RS08845	COG2894	cell division
AKG35_RS08850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKG35_RS08880	COG2890	protein-(glutamine-N5) methyltransferase activity
AKG35_RS08885	COG0758	DNA mediated transformation
AKG35_RS08885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKG35_RS08910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKG35_RS08915	COG0539	negative regulation of cytoplasmic translation
AKG35_RS08925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKG35_RS08930	COG1070	Carbohydrate kinase
AKG35_RS09020	COG5398	heme oxygenase
AKG35_RS09035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKG35_RS09040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKG35_RS09040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKG35_RS09045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKG35_RS09050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKG35_RS09130	COG0408	coproporphyrinogen oxidase activity
AKG35_RS09135	COG0489	protein tyrosine kinase activity
AKG35_RS09140	COG0772	Belongs to the SEDS family
AKG35_RS09155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKG35_RS09160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AKG35_RS09165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKG35_RS09180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKG35_RS09185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKG35_RS09200	COG1606	tRNA processing
AKG35_RS09205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AKG35_RS09225	COG3001	Fructosamine kinase
AKG35_RS09230	COG1233	COG1233 Phytoene dehydrogenase and related
AKG35_RS09250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKG35_RS09265	COG3854	ATPases associated with a variety of cellular activities
AKG35_RS09280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKG35_RS09285	COG0088	Forms part of the polypeptide exit tunnel
AKG35_RS09290	COG0089	rRNA binding
AKG35_RS09295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKG35_RS09310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKG35_RS09315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKG35_RS09320	COG0255	Belongs to the universal ribosomal protein uL29 family
AKG35_RS09325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKG35_RS09330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKG35_RS09335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKG35_RS09340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKG35_RS09345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKG35_RS09350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKG35_RS09355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKG35_RS09360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKG35_RS09365	COG0200	Binds to the 23S rRNA
AKG35_RS09370	COG0201	protein transport
AKG35_RS09375	COG0563	adenylate kinase activity
AKG35_RS09380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKG35_RS09385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKG35_RS09390	COG0202	RNA polymerase activity
AKG35_RS09400	COG0101	tRNA pseudouridine synthase activity
AKG35_RS09410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKG35_RS09415	COG0254	rRNA binding
AKG35_RS09420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKG35_RS09430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKG35_RS09450	COG0463	Glycosyl transferase, family 2
AKG35_RS09470	COG2885	chlorophyll binding
AKG35_RS09475	COG2885	chlorophyll binding
AKG35_RS09490	COG0644	oxidoreductase
AKG35_RS09505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKG35_RS09515	COG0067	glutamate synthase
AKG35_RS09515	COG0070	glutamate synthase
AKG35_RS09515	COG0069	glutamate synthase activity
AKG35_RS09535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKG35_RS09540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKG35_RS09555	COG2226	methyltransferase
AKG35_RS09570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKG35_RS09575	COG1530	ribonuclease E activity
AKG35_RS09585	COG0436	Aminotransferase
AKG35_RS09590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKG35_RS09625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKG35_RS09630	COG0529	Catalyzes the synthesis of activated sulfate
AKG35_RS09630	COG2046	Belongs to the sulfate adenylyltransferase family
AKG35_RS09645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKG35_RS09670	COG1252	NADH dehydrogenase
AKG35_RS09675	COG0540	Belongs to the ATCase OTCase family
AKG35_RS09680	COG2094	Belongs to the DNA glycosylase MPG family
AKG35_RS09710	COG1402	creatininase
AKG35_RS09715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKG35_RS09730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKG35_RS09750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKG35_RS09760	COG2971	BadF BadG BcrA BcrD
AKG35_RS09765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKG35_RS09785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKG35_RS09795	COG0717	Belongs to the dCTP deaminase family
AKG35_RS09805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKG35_RS09810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKG35_RS09815	COG4372	Transposase
AKG35_RS09830	COG0193	aminoacyl-tRNA hydrolase activity
AKG35_RS09835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKG35_RS09865	COG0066	3-isopropylmalate dehydratase activity
AKG35_RS09870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKG35_RS09875	COG1058	Belongs to the CinA family
AKG35_RS09875	COG1546	Belongs to the CinA family
AKG35_RS09880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKG35_RS09885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKG35_RS09910	COG0728	peptidoglycan biosynthetic process
AKG35_RS09915	COG1489	DNA binding
AKG35_RS09920	COG0004	ammonium transporteR
AKG35_RS09925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKG35_RS09940	COG0138	bifunctional purine biosynthesis protein purh
AKG35_RS09960	COG2205	protein histidine kinase activity
AKG35_RS09965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AKG35_RS09970	COG0343	queuine tRNA-ribosyltransferase activity
AKG35_RS09990	COG1253	flavin adenine dinucleotide binding
AKG35_RS10000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKG35_RS10005	COG0354	folic acid binding
AKG35_RS10015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKG35_RS10020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKG35_RS10055	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AKG35_RS10060	COG0131	Imidazoleglycerol-phosphate dehydratase
AKG35_RS10065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKG35_RS10090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKG35_RS10095	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AKG35_RS10095	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AKG35_RS10105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKG35_RS10110	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKG35_RS10115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS10120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS10125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS10130	COG1773	rubredoxin
AKG35_RS10135	COG4447	cellulose binding
AKG35_RS10145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKG35_RS10150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKG35_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
AKG35_RS10155	COG3347	Dehydrogenase
AKG35_RS10165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKG35_RS10170	COG0124	histidyl-tRNA synthetase
AKG35_RS10175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKG35_RS10180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKG35_RS10190	COG0617	tRNA 3'-terminal CCA addition
AKG35_RS10200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKG35_RS10210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKG35_RS10240	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS10260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKG35_RS10265	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS10270	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS10275	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS10280	COG1132	(ABC) transporter
AKG35_RS10305	COG0463	Glycosyl transferase, family 2
AKG35_RS10310	COG0538	isocitrate dehydrogenase activity
AKG35_RS10325	COG0277	FAD linked oxidase domain protein
AKG35_RS10345	COG0475	glutathione-regulated potassium exporter activity
AKG35_RS10355	COG0058	SHG alpha-glucan phosphorylase activity
AKG35_RS10380	COG0571	ribonuclease III activity
AKG35_RS10390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKG35_RS10395	COG0662	Cupin 2, conserved barrel domain protein
AKG35_RS10395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AKG35_RS10400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKG35_RS10405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS10410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKG35_RS10415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKG35_RS10420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKG35_RS10425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKG35_RS10430	COG1216	Glycosyl transferase, family 2
AKG35_RS10450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKG35_RS10455	COG1472	Belongs to the glycosyl hydrolase 3 family
AKG35_RS10460	COG0457	Tetratricopeptide repeat
AKG35_RS10460	COG0463	Glycosyl transferase, family 2
AKG35_RS10465	COG1587	Uroporphyrinogen-III synthase
AKG35_RS10480	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AKG35_RS10485	COG0316	Belongs to the HesB IscA family
AKG35_RS10505	COG1090	epimerase
AKG35_RS10525	COG0484	heat shock protein binding
AKG35_RS10530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKG35_RS10535	COG3659	wide pore channel activity
AKG35_RS10580	COG1122	ATPase activity
AKG35_RS10590	COG0745	RESPONSE REGULATOR receiver
AKG35_RS10600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKG35_RS10605	COG2217	Heavy metal translocating P-type atpase
AKG35_RS10610	COG3063	Type IV pilus biogenesis stability protein PilW
AKG35_RS10615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKG35_RS10625	COG0416	fatty acid biosynthetic process
AKG35_RS10630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKG35_RS10635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKG35_RS10650	COG1214	PFAM Peptidase M22, glycoprotease
AKG35_RS10660	COG0617	tRNA 3'-terminal CCA addition
AKG35_RS10670	COG1562	ergosterol biosynthetic process
AKG35_RS10675	COG0493	'glutamate synthase
AKG35_RS10675	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AKG35_RS10690	COG0583	DNA-binding transcription factor activity
AKG35_RS10700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKG35_RS10705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS10715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKG35_RS10725	COG2197	response regulator
AKG35_RS10730	COG2954	triphosphatase activity
AKG35_RS10735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKG35_RS10740	COG0713	ATP synthesis coupled electron transport
AKG35_RS10750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKG35_RS10755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AKG35_RS10760	COG0372	Belongs to the citrate synthase family
AKG35_RS10780	COG1420	regulation of RNA biosynthetic process
AKG35_RS10785	COG0133	tryptophan synthase activity
AKG35_RS10795	COG0023	Translation Initiation Factor
AKG35_RS10800	COG0529	Catalyzes the synthesis of activated sulfate
AKG35_RS10805	COG0628	permease
AKG35_RS10815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKG35_RS10835	COG0277	FAD linked oxidase domain protein
AKG35_RS10850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKG35_RS10860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKG35_RS10870	COG0564	pseudouridine synthase activity
AKG35_RS10875	COG0745	RESPONSE REGULATOR receiver
AKG35_RS10885	COG1104	cysteine desulfurase activity
AKG35_RS10900	COG0275	rRNA processing
AKG35_RS10905	COG0649	NAD binding
AKG35_RS10935	COG0824	Thioesterase
AKG35_RS10945	COG0318	PFAM AMP-dependent synthetase and ligase
AKG35_RS10950	COG4948	Mandelate Racemase Muconate Lactonizing
AKG35_RS10955	COG1575	Belongs to the MenA family. Type 1 subfamily
AKG35_RS10965	COG0189	ligase activity
AKG35_RS10975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKG35_RS10980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKG35_RS10990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKG35_RS10995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKG35_RS11000	COG0512	Glutamine amidotransferase of anthranilate synthase
AKG35_RS11010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKG35_RS11015	COG0018	arginyl-trna synthetase
AKG35_RS11035	COG0157	Belongs to the NadC ModD family
AKG35_RS11040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKG35_RS11060	COG0668	transmembrane transport
AKG35_RS11090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKG35_RS11095	COG0148	phosphopyruvate hydratase activity
AKG35_RS11100	COG0346	lactoylglutathione lyase activity
AKG35_RS11105	COG0542	response to heat
AKG35_RS11110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKG35_RS11115	COG0250	Participates in transcription elongation, termination and antitermination
AKG35_RS11120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKG35_RS11125	COG0081	regulation of translation
AKG35_RS11135	COG0222	ribosome binding
AKG35_RS11145	COG0328	RNA-DNA hybrid ribonuclease activity
AKG35_RS11150	COG0167	dihydroorotate dehydrogenase activity
AKG35_RS11170	COG1450	Type ii and iii secretion system protein
AKG35_RS11180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKG35_RS11185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKG35_RS11210	COG0126	phosphoglycerate kinase activity
AKG35_RS11215	COG0589	response to stress
AKG35_RS11220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKG35_RS11225	COG0564	pseudouridine synthase activity
AKG35_RS11230	COG4172	Belongs to the ABC transporter superfamily
AKG35_RS11235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKG35_RS11240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKG35_RS11375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKG35_RS11380	COG0237	dephospho-CoA kinase activity
AKG35_RS11395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKG35_RS11400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKG35_RS11400	COG2022	thiamine diphosphate biosynthetic process
AKG35_RS11420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKG35_RS11440	COG0105	UTP biosynthetic process
AKG35_RS11455	COG1166	arginine decarboxylase activity
AKG35_RS11460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKG35_RS11490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKG35_RS11495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKG35_RS11515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKG35_RS11525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKG35_RS11530	COG0426	domain, Protein
AKG35_RS11530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKG35_RS11535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKG35_RS11535	COG0426	domain, Protein
AKG35_RS11540	COG1773	rubredoxin
AKG35_RS11565	COG0509	glycine decarboxylation via glycine cleavage system
AKG35_RS11570	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AKG35_RS11595	COG0305	Participates in initiation and elongation during chromosome replication
AKG35_RS11595	COG1372	Participates in initiation and elongation during chromosome replication
AKG35_RS11595	COG0305	Participates in initiation and elongation during chromosome replication
AKG35_RS11595	COG1372	Participates in initiation and elongation during chromosome replication
AKG35_RS11600	COG0445	tRNA wobble uridine modification
AKG35_RS11635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKG35_RS11645	COG0398	Pfam SNARE associated Golgi protein
AKG35_RS11665	COG4555	ABC transporter
AKG35_RS11670	COG0525	valine-tRNA ligase activity
AKG35_RS11700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKG35_RS11705	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AKG35_RS11720	COG0259	pyridoxamine-phosphate oxidase activity
AKG35_RS11730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKG35_RS11735	COG1121	(ABC) transporter
AKG35_RS11760	COG0701	Predicted permease
AKG35_RS11785	COG3956	TIGRFAM MazG family protein
AKG35_RS11790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKG35_RS11800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKG35_RS11805	COG0010	Belongs to the arginase family
AKG35_RS11815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKG35_RS11820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKG35_RS11825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS11830	COG0783	Belongs to the Dps family
AKG35_RS11835	COG0504	CTP synthase activity
AKG35_RS11840	COG0602	queuosine metabolic process
AKG35_RS11845	COG4574	serine-type endopeptidase inhibitor activity
AKG35_RS11850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKG35_RS11890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AKG35_RS11895	COG0830	nickel cation binding
AKG35_RS11905	COG0829	nickel cation binding
AKG35_RS11910	COG0831	urea catabolic process
AKG35_RS11915	COG0832	Belongs to the urease beta subunit family
AKG35_RS11920	COG0804	urea catabolic process
AKG35_RS11925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKG35_RS11935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKG35_RS11945	COG2116	formate transmembrane transporter activity
AKG35_RS11970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKG35_RS11975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKG35_RS11980	COG0170	dolichyl monophosphate biosynthetic process
AKG35_RS11985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKG35_RS11990	COG1049	propionate catabolic process, 2-methylcitrate cycle
AKG35_RS12000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKG35_RS12010	COG0788	formyltetrahydrofolate deformylase activity
AKG35_RS12015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKG35_RS12020	COG0443	Heat shock 70 kDa protein
AKG35_RS12025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKG35_RS12035	COG0360	Binds together with S18 to 16S ribosomal RNA
AKG35_RS12045	COG0137	argininosuccinate synthase activity
AKG35_RS12060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKG35_RS12075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKG35_RS12080	COG0438	transferase activity, transferring glycosyl groups
AKG35_RS12090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKG35_RS12095	COG0497	DNA recombination
AKG35_RS12100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKG35_RS12110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine