locus-tag	class	description
NATL1_RS00015	COG0592	DNA-directed DNA polymerase activity
NATL1_RS00025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NATL1_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NATL1_RS00055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NATL1_RS00060	COG0552	protein localization to endoplasmic reticulum
NATL1_RS00065	COG2208	phosphoserine phosphatase activity
NATL1_RS00070	COG0165	Argininosuccinate lyase
NATL1_RS00075	COG0724	RNA recognition motif
NATL1_RS00080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NATL1_RS00090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NATL1_RS00095	COG0484	heat shock protein binding
NATL1_RS00105	COG1162	GTPase activity
NATL1_RS00110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NATL1_RS00120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NATL1_RS00125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NATL1_RS00130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NATL1_RS00135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NATL1_RS00140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NATL1_RS00145	COG0511	ligase activity, forming carbon-carbon bonds
NATL1_RS00150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NATL1_RS00185	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NATL1_RS00190	COG0519	Catalyzes the synthesis of GMP from XMP
NATL1_RS00210	COG0625	glutathione transferase activity
NATL1_RS00225	COG0457	Tetratricopeptide repeat
NATL1_RS00245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NATL1_RS00280	COG0768	penicillin binding
NATL1_RS00290	COG0426	domain, Protein
NATL1_RS00290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NATL1_RS00295	COG0426	domain, Protein
NATL1_RS00295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NATL1_RS00300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NATL1_RS00305	COG1166	arginine decarboxylase activity
NATL1_RS00310	COG0105	UTP biosynthetic process
NATL1_RS00315	COG2022	thiamine diphosphate biosynthetic process
NATL1_RS00315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NATL1_RS00320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NATL1_RS00360	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NATL1_RS00465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NATL1_RS00500	COG1132	(ABC) transporter
NATL1_RS00520	COG0116	Belongs to the methyltransferase superfamily
NATL1_RS00540	COG1196	nuclear chromosome segregation
NATL1_RS00550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NATL1_RS00560	COG0439	Biotin carboxylase
NATL1_RS00575	COG0515	serine threonine protein kinase
NATL1_RS00585	COG4178	(ABC) transporter
NATL1_RS00595	COG0537	adenosine 5'-monophosphoramidase activity
NATL1_RS00600	COG0242	peptide deformylase activity
NATL1_RS00605	COG1506	peptidase
NATL1_RS00605	COG4946	Tricorn protease homolog
NATL1_RS00605	COG0823	Involved in the tonB-independent uptake of proteins
NATL1_RS00610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NATL1_RS00615	COG0719	Fe-S assembly protein
NATL1_RS00620	COG0396	ATPase activity
NATL1_RS00625	COG0719	Fe-S assembly protein
NATL1_RS00645	COG0033	Phosphoglucomutase
NATL1_RS00650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NATL1_RS00660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NATL1_RS00665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NATL1_RS00670	COG0175	sulfate reduction
NATL1_RS00675	COG1252	NADH dehydrogenase
NATL1_RS00680	COG3273	potassium ion transport
NATL1_RS00680	COG0471	metal ion transport
NATL1_RS00685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NATL1_RS00690	COG0569	domain protein
NATL1_RS00695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NATL1_RS00715	COG0488	(ABC) transporter
NATL1_RS00720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NATL1_RS00735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NATL1_RS00740	COG1570	exodeoxyribonuclease VII activity
NATL1_RS00745	COG1722	exodeoxyribonuclease VII activity
NATL1_RS00760	COG0483	inositol monophosphate 1-phosphatase activity
NATL1_RS00765	COG1538	Outer membrane efflux protein
NATL1_RS00785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NATL1_RS00790	COG4243	Vitamin k epoxide reductase
NATL1_RS00815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NATL1_RS00815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NATL1_RS00850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NATL1_RS00855	COG1472	Belongs to the glycosyl hydrolase 3 family
NATL1_RS00860	COG1587	Uroporphyrinogen-III synthase
NATL1_RS00870	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NATL1_RS00875	COG0316	Belongs to the HesB IscA family
NATL1_RS00885	COG1090	epimerase
NATL1_RS00895	COG0484	heat shock protein binding
NATL1_RS00900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NATL1_RS00915	COG1122	ATPase activity
NATL1_RS00925	COG0745	RESPONSE REGULATOR receiver
NATL1_RS00930	COG0470	DNA polymerase III
NATL1_RS00935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NATL1_RS00940	COG2217	Heavy metal translocating P-type atpase
NATL1_RS00945	COG3063	Type IV pilus biogenesis stability protein PilW
NATL1_RS00950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NATL1_RS00960	COG0416	fatty acid biosynthetic process
NATL1_RS00970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NATL1_RS00990	COG0617	tRNA 3'-terminal CCA addition
NATL1_RS00995	COG0724	RNA recognition motif
NATL1_RS01000	COG1562	ergosterol biosynthetic process
NATL1_RS01005	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NATL1_RS01005	COG0493	'glutamate synthase
NATL1_RS01020	COG0583	DNA-binding transcription factor activity
NATL1_RS01030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NATL1_RS01035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS01045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NATL1_RS01070	COG0713	ATP synthesis coupled electron transport
NATL1_RS01080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS01085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NATL1_RS01090	COG0372	Belongs to the citrate synthase family
NATL1_RS01105	COG0133	tryptophan synthase activity
NATL1_RS01110	COG0023	Translation Initiation Factor
NATL1_RS01115	COG0529	Catalyzes the synthesis of activated sulfate
NATL1_RS01120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NATL1_RS01130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NATL1_RS01135	COG0745	RESPONSE REGULATOR receiver
NATL1_RS01140	COG1104	cysteine desulfurase activity
NATL1_RS01145	COG0275	rRNA processing
NATL1_RS01150	COG0649	NAD binding
NATL1_RS01155	COG0824	Thioesterase
NATL1_RS01160	COG0318	PFAM AMP-dependent synthetase and ligase
NATL1_RS01170	COG1575	Belongs to the MenA family. Type 1 subfamily
NATL1_RS01175	COG1169	isochorismate synthase
NATL1_RS01180	COG0189	ligase activity
NATL1_RS01190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NATL1_RS01205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NATL1_RS01220	COG0018	arginyl-trna synthetase
NATL1_RS01225	COG0157	Belongs to the NadC ModD family
NATL1_RS01230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NATL1_RS01240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NATL1_RS01250	COG0564	pseudouridine synthase activity
NATL1_RS01255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NATL1_RS01260	COG0126	phosphoglycerate kinase activity
NATL1_RS01270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NATL1_RS01275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NATL1_RS01280	COG0167	dihydroorotate dehydrogenase activity
NATL1_RS01285	COG0328	RNA-DNA hybrid ribonuclease activity
NATL1_RS01290	COG0222	ribosome binding
NATL1_RS01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NATL1_RS01300	COG0081	regulation of translation
NATL1_RS01305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NATL1_RS01310	COG0250	Participates in transcription elongation, termination and antitermination
NATL1_RS01315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NATL1_RS01320	COG0542	response to heat
NATL1_RS01325	COG0148	phosphopyruvate hydratase activity
NATL1_RS01330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NATL1_RS01340	COG0492	ferredoxin-NADP+ reductase activity
NATL1_RS01355	COG0659	secondary active sulfate transmembrane transporter activity
NATL1_RS01360	COG0484	heat shock protein binding
NATL1_RS01365	COG0113	porphobilinogen synthase activity
NATL1_RS01375	COG1193	negative regulation of DNA recombination
NATL1_RS01380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NATL1_RS01400	COG0435	Glutathione S-transferase
NATL1_RS01405	COG2988	succinylglutamate desuccinylase activity
NATL1_RS01415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NATL1_RS01425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NATL1_RS01430	COG2046	Belongs to the sulfate adenylyltransferase family
NATL1_RS01440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NATL1_RS01450	COG0540	Belongs to the ATCase OTCase family
NATL1_RS01455	COG2094	Belongs to the DNA glycosylase MPG family
NATL1_RS01460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NATL1_RS01480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NATL1_RS01490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NATL1_RS01495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NATL1_RS01500	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NATL1_RS01505	COG0717	Belongs to the dCTP deaminase family
NATL1_RS01515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NATL1_RS01520	COG4372	Transposase
NATL1_RS01535	COG0193	aminoacyl-tRNA hydrolase activity
NATL1_RS01540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NATL1_RS01555	COG0066	3-isopropylmalate dehydratase activity
NATL1_RS01560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NATL1_RS01565	COG1058	Belongs to the CinA family
NATL1_RS01565	COG1546	Belongs to the CinA family
NATL1_RS01570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NATL1_RS01590	COG0728	peptidoglycan biosynthetic process
NATL1_RS01595	COG1489	DNA binding
NATL1_RS01600	COG0004	ammonium transporteR
NATL1_RS01605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NATL1_RS01615	COG0138	bifunctional purine biosynthesis protein purh
NATL1_RS01630	COG2205	protein histidine kinase activity
NATL1_RS01635	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NATL1_RS01640	COG0343	queuine tRNA-ribosyltransferase activity
NATL1_RS01650	COG0673	inositol 2-dehydrogenase activity
NATL1_RS01655	COG1253	flavin adenine dinucleotide binding
NATL1_RS01665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NATL1_RS01670	COG0354	folic acid binding
NATL1_RS01680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NATL1_RS01685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NATL1_RS01690	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NATL1_RS01695	COG0131	Imidazoleglycerol-phosphate dehydratase
NATL1_RS01700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NATL1_RS01715	COG0415	Belongs to the DNA photolyase family
NATL1_RS01720	COG0494	nUDIX hydrolase
NATL1_RS01725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NATL1_RS01730	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NATL1_RS01730	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NATL1_RS01745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NATL1_RS01750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS01755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS01760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS01765	COG1773	rubredoxin
NATL1_RS01785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NATL1_RS01790	COG0709	Synthesizes selenophosphate from selenide and ATP
NATL1_RS01795	COG0617	tRNA 3'-terminal CCA addition
NATL1_RS01795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NATL1_RS01795	COG0517	IMP dehydrogenase activity
NATL1_RS01845	COG0237	dephospho-CoA kinase activity
NATL1_RS01855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NATL1_RS01890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NATL1_RS01900	COG0539	negative regulation of cytoplasmic translation
NATL1_RS01905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NATL1_RS01920	COG0824	Thioesterase
NATL1_RS01925	COG2890	protein-(glutamine-N5) methyltransferase activity
NATL1_RS01940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NATL1_RS01945	COG2894	cell division
NATL1_RS01950	COG0850	regulation of cytokinetic process
NATL1_RS01955	COG1078	dGTPase activity
NATL1_RS01960	COG0793	Belongs to the peptidase S41A family
NATL1_RS01965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NATL1_RS01970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NATL1_RS02005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NATL1_RS02020	COG0791	NLP P60 protein
NATL1_RS02020	COG1388	LysM domain
NATL1_RS02025	COG1012	belongs to the aldehyde dehydrogenase family
NATL1_RS02105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NATL1_RS02115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NATL1_RS02120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NATL1_RS02130	COG1160	GTP binding
NATL1_RS02135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NATL1_RS02150	COG1799	cell septum assembly
NATL1_RS02155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NATL1_RS02160	COG0438	transferase activity, transferring glycosyl groups
NATL1_RS02170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NATL1_RS02175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NATL1_RS02180	COG0321	lipoyl(octanoyl) transferase activity
NATL1_RS02185	COG1022	Amp-dependent synthetase and ligase
NATL1_RS02195	COG0508	dehydrogenase complex catalyzes the overall conversion of
NATL1_RS02200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NATL1_RS02205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NATL1_RS02210	COG0626	cystathionine gamma-synthase activity
NATL1_RS02215	COG0626	cystathionine gamma-synthase activity
NATL1_RS02220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NATL1_RS02225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NATL1_RS02235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NATL1_RS02260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NATL1_RS02265	COG0579	oxidoreductase
NATL1_RS02270	COG0481	GTPase activity
NATL1_RS02275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NATL1_RS02280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NATL1_RS02290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NATL1_RS02290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NATL1_RS02295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NATL1_RS02305	COG0107	imidazoleglycerol-phosphate synthase activity
NATL1_RS02310	COG2226	methyltransferase
NATL1_RS02320	COG1842	Phage shock protein A
NATL1_RS02325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NATL1_RS02325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NATL1_RS02330	COG1136	(ABC) transporter
NATL1_RS02340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NATL1_RS02355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NATL1_RS02375	COG1845	cytochrome c oxidase, subunit III
NATL1_RS02380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NATL1_RS02390	COG1612	heme a metabolic process
NATL1_RS02395	COG0109	protoheme IX farnesyltransferase activity
NATL1_RS02415	COG0459	protein refolding
NATL1_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
NATL1_RS02430	COG1619	proteins homologs of microcin C7 resistance protein MccF
NATL1_RS02435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NATL1_RS02455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NATL1_RS02460	COG3258	Cytochrome c
NATL1_RS02465	COG0723	plastoquinol--plastocyanin reductase activity
NATL1_RS02475	COG0805	protein transport
NATL1_RS02500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NATL1_RS02520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NATL1_RS02545	COG0024	Methionine aminopeptidase
NATL1_RS02550	COG3000	fatty acid hydroxylase
NATL1_RS02550	COG0300	oxidoreductase activity
NATL1_RS02555	COG0857	belongs to the CobB CobQ family
NATL1_RS02565	COG1666	GTP binding
NATL1_RS02580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NATL1_RS02600	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NATL1_RS02605	COG0392	lysyltransferase activity
NATL1_RS02610	COG4176	ABC-type proline glycine betaine transport system permease component
NATL1_RS02615	COG0523	cobalamin synthesis protein
NATL1_RS02625	COG0432	Pfam Uncharacterised protein family UPF0047
NATL1_RS02630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NATL1_RS02635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NATL1_RS02640	COG0181	hydroxymethylbilane synthase activity
NATL1_RS02645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NATL1_RS02650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NATL1_RS02660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NATL1_RS02675	COG0629	single-stranded DNA binding
NATL1_RS02690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NATL1_RS02695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NATL1_RS02705	COG0442	prolyl-tRNA aminoacylation
NATL1_RS02720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NATL1_RS02735	COG0588	phosphoglycerate mutase activity
NATL1_RS02750	COG0768	penicillin binding
NATL1_RS02755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NATL1_RS02765	COG0233	cytoplasmic translational termination
NATL1_RS02770	COG0528	UMP kinase activity
NATL1_RS02780	COG0582	viral genome integration into host DNA
NATL1_RS02785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NATL1_RS02790	COG0028	Belongs to the TPP enzyme family
NATL1_RS02805	COG0539	negative regulation of cytoplasmic translation
NATL1_RS02815	COG3396	Phenylacetate-CoA oxygenase
NATL1_RS02820	COG5322	oxidoreductase activity
NATL1_RS02825	COG0825	malonyl-CoA metabolic process
NATL1_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
NATL1_RS02835	COG0135	phosphoribosylanthranilate isomerase activity
NATL1_RS02840	COG1994	Peptidase M50
NATL1_RS02840	COG0517	IMP dehydrogenase activity
NATL1_RS02845	COG0095	Lipoate-protein ligase
NATL1_RS02860	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NATL1_RS02865	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NATL1_RS02870	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NATL1_RS02880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NATL1_RS02885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NATL1_RS02890	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NATL1_RS02895	COG1850	ribulose-bisphosphate carboxylase activity
NATL1_RS02900	COG4451	ribulose bisphosphate carboxylase, small
NATL1_RS02925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NATL1_RS02940	COG0251	oxidation-reduction process
NATL1_RS02945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NATL1_RS02950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NATL1_RS02955	COG1132	(ABC) transporter
NATL1_RS02960	COG0456	acetyltransferase
NATL1_RS02975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NATL1_RS02985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NATL1_RS02995	COG0418	dihydroorotase activity
NATL1_RS03015	COG0159	tryptophan synthase activity
NATL1_RS03025	COG2010	Cytochrome c
NATL1_RS03040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NATL1_RS03045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NATL1_RS03045	COG0140	phosphoribosyl-ATP diphosphatase activity
NATL1_RS03055	COG0542	response to heat
NATL1_RS03060	COG3794	PFAM blue (type 1) copper domain protein
NATL1_RS03070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NATL1_RS03075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NATL1_RS03105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NATL1_RS03120	COG0339	signal peptide processing
NATL1_RS03125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS03130	COG0083	homoserine kinase activity
NATL1_RS03135	COG0837	glucose binding
NATL1_RS03140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NATL1_RS03145	COG0180	Tryptophanyl-tRNA synthetase
NATL1_RS03165	COG1121	(ABC) transporter
NATL1_RS03170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NATL1_RS03185	COG0681	Belongs to the peptidase S26 family
NATL1_RS03190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NATL1_RS03195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NATL1_RS03200	COG0297	glycogen (starch) synthase activity
NATL1_RS03205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NATL1_RS03225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NATL1_RS03230	COG2045	Belongs to the ComB family
NATL1_RS03240	COG0860	N-Acetylmuramoyl-L-alanine amidase
NATL1_RS03245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NATL1_RS03250	COG0142	geranyltranstransferase activity
NATL1_RS03260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NATL1_RS03270	COG2176	DNA-directed DNA polymerase activity
NATL1_RS03280	COG0124	histidyl-tRNA synthetase
NATL1_RS03285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NATL1_RS03335	COG0300	oxidoreductase activity
NATL1_RS03340	COG0644	oxidoreductase
NATL1_RS03395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NATL1_RS03445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NATL1_RS03450	COG2226	methyltransferase
NATL1_RS03455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NATL1_RS03465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NATL1_RS03485	COG1836	PFAM Integral membrane protein DUF92
NATL1_RS03500	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NATL1_RS03505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NATL1_RS03510	COG0436	Aminotransferase
NATL1_RS03520	COG1573	uracil-dna glycosylase
NATL1_RS03525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NATL1_RS03530	COG0793	Belongs to the peptidase S41A family
NATL1_RS03540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NATL1_RS03560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NATL1_RS03565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NATL1_RS03640	COG2081	HI0933 family
NATL1_RS03670	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NATL1_RS03675	COG0515	serine threonine protein kinase
NATL1_RS03690	COG2226	methyltransferase
NATL1_RS03695	COG0174	glutamine synthetase
NATL1_RS03700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NATL1_RS03715	COG1160	GTP binding
NATL1_RS03720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NATL1_RS03740	COG0612	Peptidase, M16
NATL1_RS03765	COG1216	Glycosyl transferase, family 2
NATL1_RS03770	COG0052	Belongs to the universal ribosomal protein uS2 family
NATL1_RS03775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NATL1_RS03785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NATL1_RS03790	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NATL1_RS03795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NATL1_RS03800	COG0751	glycine-tRNA ligase activity
NATL1_RS03805	COG0644	oxidoreductase
NATL1_RS03815	COG1217	gtp-binding protein TYPA
NATL1_RS03830	COG1137	ATPase activity
NATL1_RS03840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NATL1_RS03845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NATL1_RS03850	COG1494	fructose-1,6-bisphosphatase
NATL1_RS03855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NATL1_RS03860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NATL1_RS03865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NATL1_RS03870	COG0363	glucosamine-6-phosphate deaminase activity
NATL1_RS03895	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NATL1_RS03910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NATL1_RS03920	COG3588	fructose-bisphosphate aldolase
NATL1_RS03925	COG0673	inositol 2-dehydrogenase activity
NATL1_RS03935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NATL1_RS03945	COG3954	Phosphoribulokinase
NATL1_RS03975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NATL1_RS03990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NATL1_RS03995	COG2197	response regulator
NATL1_RS04000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NATL1_RS04010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NATL1_RS04030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NATL1_RS04035	COG3842	ATPase activity
NATL1_RS04070	COG1119	ATPase activity
NATL1_RS04080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NATL1_RS04090	COG1091	dTDP-4-dehydrorhamnose reductase activity
NATL1_RS04095	COG1088	dTDP-glucose 4,6-dehydratase activity
NATL1_RS04100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NATL1_RS04110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NATL1_RS04130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NATL1_RS04135	COG0367	asparagine synthase
NATL1_RS04170	COG2089	acid synthase
NATL1_RS04185	COG0107	imidazoleglycerol-phosphate synthase activity
NATL1_RS04190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NATL1_RS04260	COG0799	negative regulation of ribosome biogenesis
NATL1_RS04270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NATL1_RS04275	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NATL1_RS04295	COG2084	Dehydrogenase
NATL1_RS04305	COG4555	ABC transporter
NATL1_RS04360	COG0463	Glycosyl transferase, family 2
NATL1_RS04365	COG0366	Alpha amylase catalytic
NATL1_RS04370	COG3769	mannosylglycerate metabolic process
NATL1_RS04390	COG1968	undecaprenyl-diphosphatase activity
NATL1_RS04415	COG1132	(ABC) transporter
NATL1_RS04425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NATL1_RS04430	COG0505	Belongs to the CarA family
NATL1_RS04440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NATL1_RS04445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NATL1_RS04455	COG0154	amidase activity
NATL1_RS04460	COG0587	DNA-directed DNA polymerase activity
NATL1_RS04470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NATL1_RS04475	COG0632	four-way junction helicase activity
NATL1_RS04515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NATL1_RS04525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NATL1_RS04530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NATL1_RS04540	COG0022	dehydrogenase e1 component
NATL1_RS04540	COG0508	dehydrogenase complex catalyzes the overall conversion of
NATL1_RS04545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NATL1_RS04550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NATL1_RS04595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NATL1_RS04600	COG1136	(ABC) transporter
NATL1_RS04600	COG0577	efflux transmembrane transporter activity
NATL1_RS04605	COG0469	pyruvate kinase activity
NATL1_RS04615	COG0762	integral membrane protein
NATL1_RS04625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NATL1_RS04630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NATL1_RS04650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NATL1_RS04655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NATL1_RS04660	COG0326	Molecular chaperone. Has ATPase activity
NATL1_RS04665	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NATL1_RS04670	COG0483	inositol monophosphate 1-phosphatase activity
NATL1_RS04685	COG0581	inorganic phosphate transmembrane transporter activity
NATL1_RS04690	COG0573	inorganic phosphate transmembrane transporter activity
NATL1_RS04695	COG0443	Heat shock 70 kDa protein
NATL1_RS04700	COG0484	heat shock protein binding
NATL1_RS04710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NATL1_RS04715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NATL1_RS04720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NATL1_RS04720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NATL1_RS04725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NATL1_RS04735	COG0166	Belongs to the GPI family
NATL1_RS04740	COG0495	leucyl-tRNA aminoacylation
NATL1_RS04745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NATL1_RS04750	COG1104	cysteine desulfurase activity
NATL1_RS04765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NATL1_RS04770	COG0426	domain, Protein
NATL1_RS04770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NATL1_RS04775	COG0322	excinuclease ABC activity
NATL1_RS04780	COG1981	membrane
NATL1_RS04785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NATL1_RS04785	COG1796	DNA polymerase
NATL1_RS04795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NATL1_RS04800	COG1410	methionine synthase
NATL1_RS04800	COG0646	methionine synthase
NATL1_RS04830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NATL1_RS04835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NATL1_RS04840	COG0557	exoribonuclease II activity
NATL1_RS04845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NATL1_RS04920	COG0450	alkyl hydroperoxide reductase
NATL1_RS04925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NATL1_RS04930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NATL1_RS04945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NATL1_RS04945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NATL1_RS04950	COG2119	membrane
NATL1_RS04960	COG0557	exoribonuclease II activity
NATL1_RS04965	COG0163	prenyltransferase activity
NATL1_RS04980	COG0312	modulator of DNA gyrase
NATL1_RS04985	COG0312	modulator of DNA gyrase
NATL1_RS04990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NATL1_RS04995	COG0861	Integral membrane protein TerC family
NATL1_RS05005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NATL1_RS05035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NATL1_RS05060	COG1429	ligase activity, forming nitrogen-metal bonds
NATL1_RS05065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NATL1_RS05070	COG0149	triose-phosphate isomerase activity
NATL1_RS05080	COG1132	(ABC) transporter
NATL1_RS05150	COG3340	Belongs to the peptidase S51 family
NATL1_RS05260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NATL1_RS05320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NATL1_RS05330	COG0011	TIGRFAM Protein of
NATL1_RS05390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NATL1_RS05395	COG0745	RESPONSE REGULATOR receiver
NATL1_RS05400	COG5002	protein histidine kinase activity
NATL1_RS05435	COG2059	Chromate
NATL1_RS05445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NATL1_RS05450	COG0640	Transcriptional regulator
NATL1_RS05455	COG0798	PFAM Bile acid sodium symporter
NATL1_RS05570	COG2135	peptidase activity
NATL1_RS05655	COG1233	COG1233 Phytoene dehydrogenase and related
NATL1_RS05725	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NATL1_RS05765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NATL1_RS05765	COG0519	Catalyzes the synthesis of GMP from XMP
NATL1_RS06235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NATL1_RS06280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NATL1_RS06300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NATL1_RS06315	COG1187	pseudouridine synthase activity
NATL1_RS06375	COG0765	amino acid transport
NATL1_RS06380	COG4597	amino acid ABC transporter
NATL1_RS06385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NATL1_RS06515	COG0659	secondary active sulfate transmembrane transporter activity
NATL1_RS06545	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NATL1_RS06550	COG1233	COG1233 Phytoene dehydrogenase and related
NATL1_RS06555	COG0745	RESPONSE REGULATOR receiver
NATL1_RS06565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NATL1_RS06570	COG0271	Belongs to the BolA IbaG family
NATL1_RS06580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NATL1_RS06585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NATL1_RS06595	COG1074	ATP-dependent DNA helicase activity
NATL1_RS06600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NATL1_RS06605	COG0513	Belongs to the DEAD box helicase family
NATL1_RS06615	COG1132	(ABC) transporter
NATL1_RS06630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NATL1_RS06640	COG1054	Belongs to the UPF0176 family
NATL1_RS06645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NATL1_RS06650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NATL1_RS06655	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NATL1_RS06660	COG0019	diaminopimelate decarboxylase activity
NATL1_RS06665	COG0456	acetyltransferase
NATL1_RS06665	COG1214	PFAM Peptidase M22, glycoprotease
NATL1_RS06670	COG0542	response to heat
NATL1_RS06675	COG0371	Dehydrogenase
NATL1_RS06690	COG0575	Belongs to the CDS family
NATL1_RS06695	COG1982	Orn Lys Arg decarboxylase major
NATL1_RS06700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NATL1_RS06715	COG1640	4-alpha-glucanotransferase
NATL1_RS06720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NATL1_RS06725	COG0308	aminopeptidase N
NATL1_RS06740	COG2205	protein histidine kinase activity
NATL1_RS06750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NATL1_RS06755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NATL1_RS06765	COG1797	cobyrinic acid a,c-diamide synthase activity
NATL1_RS06785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NATL1_RS06790	COG1480	7TM receptor with intracellular HD hydrolase
NATL1_RS06805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NATL1_RS06810	COG1543	Belongs to the glycosyl hydrolase 57 family
NATL1_RS06815	COG0644	oxidoreductase
NATL1_RS06820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NATL1_RS06825	COG0516	GMP reductase activity
NATL1_RS06830	COG3118	belongs to the thioredoxin family
NATL1_RS06845	COG2010	Cytochrome c
NATL1_RS06850	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NATL1_RS06860	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NATL1_RS06865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NATL1_RS06870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NATL1_RS06875	COG2166	iron-sulfur cluster assembly
NATL1_RS06880	COG0460	homoserine dehydrogenase
NATL1_RS06895	COG0601	transmembrane transport
NATL1_RS07000	COG3046	protein related to deoxyribodipyrimidine photolyase
NATL1_RS07005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NATL1_RS07035	COG2308	Evidence 4 Homologs of previously reported genes of
NATL1_RS07050	COG0457	Tetratricopeptide repeat
NATL1_RS07085	COG0457	Tetratricopeptide repeat
NATL1_RS07105	COG0012	GTP binding
NATL1_RS07110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NATL1_RS07115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NATL1_RS07115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NATL1_RS07120	COG0215	cysteine-tRNA ligase activity
NATL1_RS07125	COG0733	neurotransmitter:sodium symporter activity
NATL1_RS07130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NATL1_RS07165	COG0492	ferredoxin-NADP+ reductase activity
NATL1_RS07170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NATL1_RS07190	COG2267	carboxylic ester hydrolase activity
NATL1_RS07195	COG0440	acetolactate synthase activity
NATL1_RS07200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NATL1_RS07220	COG0424	maF-like protein
NATL1_RS07230	COG1492	cobalamin metabolic process
NATL1_RS07265	COG1840	ABC-type Fe3 transport system, periplasmic component
NATL1_RS07270	COG3128	pkhd-type hydroxylase
NATL1_RS07280	COG3659	wide pore channel activity
NATL1_RS07285	COG0752	glycyl-tRNA synthetase alpha subunit
NATL1_RS07365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NATL1_RS07370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NATL1_RS07400	COG0716	FMN binding
NATL1_RS07410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NATL1_RS07420	COG0697	spore germination
NATL1_RS07425	COG0616	signal peptide processing
NATL1_RS07440	COG0594	ribonuclease P activity
NATL1_RS07450	COG0706	membrane insertase activity
NATL1_RS07460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NATL1_RS07465	COG0750	zinc metalloprotease
NATL1_RS07470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NATL1_RS07475	COG1185	polyribonucleotide nucleotidyltransferase activity
NATL1_RS07480	COG1218	3'(2'),5'-bisphosphate nucleotidase
NATL1_RS07485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NATL1_RS07545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NATL1_RS07550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NATL1_RS07555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NATL1_RS07560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NATL1_RS07560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NATL1_RS07590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NATL1_RS07600	COG0196	riboflavin kinase activity
NATL1_RS07620	COG1691	(AIR) carboxylase
NATL1_RS07630	COG0336	Belongs to the RNA methyltransferase TrmD family
NATL1_RS07635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NATL1_RS07645	COG0670	Belongs to the BI1 family
NATL1_RS07650	COG1702	phosphate starvation-inducible protein PhoH
NATL1_RS07655	COG0228	four-way junction DNA binding
NATL1_RS07660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NATL1_RS07670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NATL1_RS07675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NATL1_RS07680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NATL1_RS07680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NATL1_RS07685	COG0482	sulfurtransferase activity
NATL1_RS07690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NATL1_RS07710	COG0134	indole-3-glycerol-phosphate synthase activity
NATL1_RS07715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NATL1_RS07720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NATL1_RS07725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NATL1_RS07730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NATL1_RS07740	COG0285	dihydrofolate synthase activity
NATL1_RS07760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NATL1_RS07765	COG1181	Belongs to the D-alanine--D-alanine ligase family
NATL1_RS07780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NATL1_RS07785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NATL1_RS07790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NATL1_RS07795	COG4956	integral membrane protein (PIN domain superfamily)
NATL1_RS07800	COG0740	serine-type endopeptidase activity
NATL1_RS07810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NATL1_RS07820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NATL1_RS07865	COG0776	regulation of translation
NATL1_RS07880	COG2211	Major facilitator Superfamily
NATL1_RS07885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NATL1_RS07900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NATL1_RS07905	COG0284	orotidine-5'-phosphate decarboxylase activity
NATL1_RS07925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NATL1_RS07930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NATL1_RS07940	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NATL1_RS07945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NATL1_RS07950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NATL1_RS07960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NATL1_RS07965	COG0151	Belongs to the GarS family
NATL1_RS07970	COG5002	protein histidine kinase activity
NATL1_RS07975	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NATL1_RS07985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NATL1_RS07990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NATL1_RS08000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NATL1_RS08005	COG2385	sporulation resulting in formation of a cellular spore
NATL1_RS08010	COG1234	tRNA 3'-trailer cleavage
NATL1_RS08035	COG2264	protein methyltransferase activity
NATL1_RS08040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NATL1_RS08050	COG2302	S4 RNA-binding domain
NATL1_RS08175	COG0488	(ABC) transporter
NATL1_RS08210	COG0457	Tetratricopeptide repeat
NATL1_RS08210	COG0859	PFAM glycosyl transferase family 9
NATL1_RS08270	COG0443	Heat shock 70 kDa protein
NATL1_RS08280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NATL1_RS08290	COG0459	protein refolding
NATL1_RS08295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NATL1_RS08300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NATL1_RS08305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NATL1_RS08315	COG0006	proline dipeptidase activity
NATL1_RS08320	COG1253	flavin adenine dinucleotide binding
NATL1_RS08330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NATL1_RS08335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NATL1_RS08335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NATL1_RS08340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NATL1_RS08350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NATL1_RS08355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NATL1_RS08360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NATL1_RS08365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NATL1_RS08370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NATL1_RS08375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NATL1_RS08380	COG0356	it plays a direct role in the translocation of protons across the membrane
NATL1_RS08390	COG0772	Belongs to the SEDS family
NATL1_RS08400	COG1333	cytochrome c biogenesis protein
NATL1_RS08420	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NATL1_RS08430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NATL1_RS08435	COG0114	fumarate hydratase activity
NATL1_RS08440	COG4581	dead DEAH box helicase
NATL1_RS08445	COG0156	8-amino-7-oxononanoate synthase activity
NATL1_RS08460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NATL1_RS08465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NATL1_RS08475	COG0357	Ribosomal RNA small subunit methyltransferase G
NATL1_RS08510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NATL1_RS08520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NATL1_RS08525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NATL1_RS08530	COG0085	RNA polymerase activity
NATL1_RS08535	COG0084	hydrolase, TatD family'
NATL1_RS08540	COG0268	Binds directly to 16S ribosomal RNA
NATL1_RS08550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NATL1_RS08555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NATL1_RS08560	COG0779	Required for maturation of 30S ribosomal subunits
NATL1_RS08565	COG0195	Participates in both transcription termination and antitermination
NATL1_RS08575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NATL1_RS08590	COG0302	gtp cyclohydrolase
NATL1_RS08625	COG1121	(ABC) transporter
NATL1_RS08640	COG0523	cobalamin synthesis protein
NATL1_RS08695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NATL1_RS08700	COG0830	nickel cation binding
NATL1_RS08705	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NATL1_RS08710	COG0829	nickel cation binding
NATL1_RS08715	COG0831	urea catabolic process
NATL1_RS08720	COG0832	Belongs to the urease beta subunit family
NATL1_RS08725	COG0804	urea catabolic process
NATL1_RS08750	COG0724	RNA recognition motif
NATL1_RS08765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NATL1_RS08775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NATL1_RS08780	COG0436	Aminotransferase
NATL1_RS08785	COG1530	ribonuclease E activity
NATL1_RS08790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NATL1_RS08800	COG1605	Chorismate mutase
NATL1_RS08800	COG0077	Prephenate dehydratase
NATL1_RS08805	COG2226	methyltransferase
NATL1_RS08810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NATL1_RS08815	COG0051	transcription antitermination factor activity, RNA binding
NATL1_RS08820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NATL1_RS08825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NATL1_RS08830	COG0049	tRNA binding
NATL1_RS08835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NATL1_RS08840	COG0067	glutamate synthase
NATL1_RS08840	COG0069	glutamate synthase activity
NATL1_RS08840	COG0070	glutamate synthase
NATL1_RS08850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NATL1_RS08860	COG2885	chlorophyll binding
NATL1_RS08865	COG2885	chlorophyll binding
NATL1_RS08885	COG0463	Glycosyl transferase, family 2
NATL1_RS08935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NATL1_RS08945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NATL1_RS08950	COG0254	rRNA binding
NATL1_RS08955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NATL1_RS08960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NATL1_RS08965	COG0101	tRNA pseudouridine synthase activity
NATL1_RS08970	COG0203	ribosomal protein L17
NATL1_RS08975	COG0202	RNA polymerase activity
NATL1_RS08980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NATL1_RS08985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NATL1_RS08990	COG0563	adenylate kinase activity
NATL1_RS08995	COG0201	protein transport
NATL1_RS09000	COG0200	Binds to the 23S rRNA
NATL1_RS09005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NATL1_RS09010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NATL1_RS09015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NATL1_RS09020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NATL1_RS09025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NATL1_RS09030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NATL1_RS09035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NATL1_RS09040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NATL1_RS09045	COG0255	Belongs to the universal ribosomal protein uL29 family
NATL1_RS09050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NATL1_RS09055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NATL1_RS09060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NATL1_RS09065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NATL1_RS09070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NATL1_RS09075	COG0089	rRNA binding
NATL1_RS09085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NATL1_RS09110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NATL1_RS09130	COG1233	COG1233 Phytoene dehydrogenase and related
NATL1_RS09135	COG3001	Fructosamine kinase
NATL1_RS09155	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NATL1_RS09160	COG1606	tRNA processing
NATL1_RS09165	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NATL1_RS09170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NATL1_RS09185	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NATL1_RS09190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NATL1_RS09195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NATL1_RS09210	COG0772	Belongs to the SEDS family
NATL1_RS09215	COG0489	protein tyrosine kinase activity
NATL1_RS09220	COG0408	coproporphyrinogen oxidase activity
NATL1_RS09235	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NATL1_RS09275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NATL1_RS09280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NATL1_RS09280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NATL1_RS09285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NATL1_RS09300	COG5398	heme oxygenase
NATL1_RS09305	COG0538	isocitrate dehydrogenase activity
NATL1_RS09325	COG0596	Alpha beta hydrolase
NATL1_RS09330	COG0475	glutathione-regulated potassium exporter activity
NATL1_RS09335	COG0058	SHG alpha-glucan phosphorylase activity
NATL1_RS09355	COG0571	ribonuclease III activity
NATL1_RS09365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NATL1_RS09375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NATL1_RS09380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NATL1_RS09385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NATL1_RS09390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NATL1_RS09395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NATL1_RS09400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NATL1_RS09410	COG1473	amidohydrolase
NATL1_RS09420	COG2255	four-way junction helicase activity
NATL1_RS09425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NATL1_RS09435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NATL1_RS09440	COG0745	RESPONSE REGULATOR receiver
NATL1_RS09460	COG0629	single-stranded DNA binding
NATL1_RS09465	COG0586	Pfam SNARE associated Golgi protein
NATL1_RS09475	COG0802	atpase or kinase
NATL1_RS09495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NATL1_RS09500	COG2239	Acts as a magnesium transporter
NATL1_RS09505	COG0386	Belongs to the glutathione peroxidase family
NATL1_RS09525	COG0187	DNA topoisomerase II activity
NATL1_RS09525	COG1372	Participates in initiation and elongation during chromosome replication
NATL1_RS09530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NATL1_RS09535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NATL1_RS09540	COG1725	Transcriptional regulator
NATL1_RS09545	COG1045	serine acetyltransferase
NATL1_RS09560	COG0653	protein targeting
NATL1_RS09565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NATL1_RS09600	COG0438	transferase activity, transferring glycosyl groups
NATL1_RS09610	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NATL1_RS09625	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NATL1_RS09640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NATL1_RS09650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NATL1_RS09655	COG2082	Precorrin-8x methylmutase
NATL1_RS09670	COG0556	nucleotide-excision repair
NATL1_RS09680	COG0037	tRNA processing
NATL1_RS09685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NATL1_RS09695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NATL1_RS09700	COG0544	peptidyl-prolyl cis-trans isomerase activity
NATL1_RS09710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NATL1_RS09715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NATL1_RS09720	COG1215	transferase activity, transferring glycosyl groups
NATL1_RS09730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NATL1_RS09735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NATL1_RS09745	COG2022	thiamine diphosphate biosynthetic process
NATL1_RS09755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NATL1_RS09770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NATL1_RS09770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NATL1_RS09775	COG0509	glycine decarboxylation via glycine cleavage system
NATL1_RS09780	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NATL1_RS09795	COG0359	binds to the 23S rRNA
NATL1_RS09800	COG1372	Participates in initiation and elongation during chromosome replication
NATL1_RS09800	COG0305	Participates in initiation and elongation during chromosome replication
NATL1_RS09800	COG1372	Participates in initiation and elongation during chromosome replication
NATL1_RS09800	COG0305	Participates in initiation and elongation during chromosome replication
NATL1_RS09805	COG0445	tRNA wobble uridine modification
NATL1_RS09830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NATL1_RS09835	COG0398	Pfam SNARE associated Golgi protein
NATL1_RS09865	COG3956	TIGRFAM MazG family protein
NATL1_RS09870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NATL1_RS09885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NATL1_RS09895	COG0504	CTP synthase activity
NATL1_RS09900	COG0602	queuosine metabolic process
NATL1_RS09905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NATL1_RS09910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NATL1_RS09915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NATL1_RS09920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NATL1_RS09930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NATL1_RS09935	COG2116	formate transmembrane transporter activity
NATL1_RS09945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NATL1_RS09960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NATL1_RS09965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NATL1_RS09970	COG0170	dolichyl monophosphate biosynthetic process
NATL1_RS09975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NATL1_RS09980	COG1049	propionate catabolic process, 2-methylcitrate cycle
NATL1_RS09995	COG0788	formyltetrahydrofolate deformylase activity
NATL1_RS10010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NATL1_RS10020	COG0360	Binds together with S18 to 16S ribosomal RNA
NATL1_RS10025	COG0137	argininosuccinate synthase activity
NATL1_RS10055	COG0438	transferase activity, transferring glycosyl groups
NATL1_RS10060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NATL1_RS10065	COG0497	DNA recombination
NATL1_RS10070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NATL1_RS10080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NATL1_RS10120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant