locus-tag	class	description
TX50_RS00020	COG0592	DNA-directed DNA polymerase activity
TX50_RS00030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TX50_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TX50_RS00060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TX50_RS00065	COG0552	protein localization to endoplasmic reticulum
TX50_RS00070	COG2208	phosphoserine phosphatase activity
TX50_RS00075	COG0165	Argininosuccinate lyase
TX50_RS00080	COG0724	RNA recognition motif
TX50_RS00085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TX50_RS00095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TX50_RS00100	COG0484	heat shock protein binding
TX50_RS00115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TX50_RS00120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TX50_RS00125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TX50_RS00130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TX50_RS00135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TX50_RS00140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX50_RS00145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TX50_RS00150	COG0511	ligase activity, forming carbon-carbon bonds
TX50_RS00155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TX50_RS00195	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TX50_RS00200	COG0519	Catalyzes the synthesis of GMP from XMP
TX50_RS00215	COG0768	penicillin binding
TX50_RS00225	COG0426	domain, Protein
TX50_RS00225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TX50_RS00230	COG0426	domain, Protein
TX50_RS00230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TX50_RS00235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TX50_RS00240	COG1166	arginine decarboxylase activity
TX50_RS00245	COG0105	UTP biosynthetic process
TX50_RS00250	COG2022	thiamine diphosphate biosynthetic process
TX50_RS00250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX50_RS00255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TX50_RS00260	COG0237	dephospho-CoA kinase activity
TX50_RS00265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TX50_RS00280	COG0116	Belongs to the methyltransferase superfamily
TX50_RS00300	COG1196	nuclear chromosome segregation
TX50_RS00310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX50_RS00320	COG0439	Biotin carboxylase
TX50_RS00335	COG0515	serine threonine protein kinase
TX50_RS00345	COG4178	(ABC) transporter
TX50_RS00355	COG0537	adenosine 5'-monophosphoramidase activity
TX50_RS00360	COG0242	peptide deformylase activity
TX50_RS00370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TX50_RS00375	COG0719	Fe-S assembly protein
TX50_RS00380	COG0396	ATPase activity
TX50_RS00385	COG0719	Fe-S assembly protein
TX50_RS00405	COG0033	Phosphoglucomutase
TX50_RS00410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TX50_RS00420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX50_RS00430	COG0175	sulfate reduction
TX50_RS00435	COG1252	NADH dehydrogenase
TX50_RS00440	COG3273	potassium ion transport
TX50_RS00440	COG0471	metal ion transport
TX50_RS00445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TX50_RS00450	COG0569	domain protein
TX50_RS00475	COG0488	(ABC) transporter
TX50_RS00480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX50_RS00530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TX50_RS00535	COG4243	Vitamin k epoxide reductase
TX50_RS00540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TX50_RS00560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX50_RS00560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX50_RS00590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TX50_RS00595	COG1587	Uroporphyrinogen-III synthase
TX50_RS00605	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TX50_RS00610	COG0316	Belongs to the HesB IscA family
TX50_RS00630	COG1090	epimerase
TX50_RS00640	COG0484	heat shock protein binding
TX50_RS00645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TX50_RS00655	COG1122	ATPase activity
TX50_RS00680	COG0470	DNA polymerase III
TX50_RS00685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TX50_RS00690	COG2217	Heavy metal translocating P-type atpase
TX50_RS00695	COG3063	Type IV pilus biogenesis stability protein PilW
TX50_RS00700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TX50_RS00710	COG0416	fatty acid biosynthetic process
TX50_RS00715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TX50_RS00720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TX50_RS00740	COG0617	tRNA 3'-terminal CCA addition
TX50_RS00750	COG1562	ergosterol biosynthetic process
TX50_RS00755	COG0493	'glutamate synthase
TX50_RS00755	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TX50_RS00770	COG0583	DNA-binding transcription factor activity
TX50_RS00780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TX50_RS00785	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS00795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TX50_RS00805	COG2197	response regulator
TX50_RS00815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TX50_RS00820	COG0713	ATP synthesis coupled electron transport
TX50_RS00825	COG0839	Belongs to the complex I subunit 6 family
TX50_RS00830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS00835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TX50_RS00840	COG0372	Belongs to the citrate synthase family
TX50_RS00855	COG0133	tryptophan synthase activity
TX50_RS00860	COG0023	Translation Initiation Factor
TX50_RS00865	COG0529	Catalyzes the synthesis of activated sulfate
TX50_RS00870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TX50_RS00875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TX50_RS00880	COG0745	RESPONSE REGULATOR receiver
TX50_RS00890	COG0275	rRNA processing
TX50_RS00895	COG0649	NAD binding
TX50_RS00900	COG0824	Thioesterase
TX50_RS00910	COG4948	Mandelate Racemase Muconate Lactonizing
TX50_RS00915	COG1575	Belongs to the MenA family. Type 1 subfamily
TX50_RS00920	COG1169	isochorismate synthase
TX50_RS00925	COG0189	ligase activity
TX50_RS00930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TX50_RS00935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TX50_RS00945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TX50_RS00950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TX50_RS00955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TX50_RS00955	COG0512	Glutamine amidotransferase of anthranilate synthase
TX50_RS00965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TX50_RS00970	COG0018	arginyl-trna synthetase
TX50_RS00975	COG0157	Belongs to the NadC ModD family
TX50_RS00980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TX50_RS00990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TX50_RS00995	COG4172	Belongs to the ABC transporter superfamily
TX50_RS01000	COG0564	pseudouridine synthase activity
TX50_RS01005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TX50_RS01010	COG0126	phosphoglycerate kinase activity
TX50_RS01020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TX50_RS01025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TX50_RS01030	COG0167	dihydroorotate dehydrogenase activity
TX50_RS01035	COG0328	RNA-DNA hybrid ribonuclease activity
TX50_RS01040	COG0222	ribosome binding
TX50_RS01045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TX50_RS01050	COG0081	regulation of translation
TX50_RS01055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TX50_RS01060	COG0250	Participates in transcription elongation, termination and antitermination
TX50_RS01065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TX50_RS01070	COG0542	response to heat
TX50_RS01075	COG0148	phosphopyruvate hydratase activity
TX50_RS01080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX50_RS01090	COG0492	ferredoxin-NADP+ reductase activity
TX50_RS01105	COG0659	secondary active sulfate transmembrane transporter activity
TX50_RS01110	COG0113	porphobilinogen synthase activity
TX50_RS01120	COG1193	negative regulation of DNA recombination
TX50_RS01125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TX50_RS01140	COG0435	Glutathione S-transferase
TX50_RS01145	COG2988	succinylglutamate desuccinylase activity
TX50_RS01155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TX50_RS01165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX50_RS01170	COG0529	Catalyzes the synthesis of activated sulfate
TX50_RS01170	COG2046	Belongs to the sulfate adenylyltransferase family
TX50_RS01180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TX50_RS01200	COG0540	Belongs to the ATCase OTCase family
TX50_RS01205	COG2094	Belongs to the DNA glycosylase MPG family
TX50_RS01210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TX50_RS01235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TX50_RS01245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TX50_RS01250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TX50_RS01255	COG3118	belongs to the thioredoxin family
TX50_RS01260	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TX50_RS01265	COG0717	Belongs to the dCTP deaminase family
TX50_RS01275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX50_RS01280	COG4372	Transposase
TX50_RS01295	COG0193	aminoacyl-tRNA hydrolase activity
TX50_RS01320	COG0066	3-isopropylmalate dehydratase activity
TX50_RS01325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TX50_RS01330	COG1546	Belongs to the CinA family
TX50_RS01330	COG1058	Belongs to the CinA family
TX50_RS01335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TX50_RS01355	COG0728	peptidoglycan biosynthetic process
TX50_RS01360	COG1489	DNA binding
TX50_RS01365	COG0004	ammonium transporteR
TX50_RS01370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TX50_RS01380	COG0138	bifunctional purine biosynthesis protein purh
TX50_RS01400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TX50_RS01405	COG0343	queuine tRNA-ribosyltransferase activity
TX50_RS01415	COG0673	inositol 2-dehydrogenase activity
TX50_RS01420	COG1253	flavin adenine dinucleotide binding
TX50_RS01430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TX50_RS01445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TX50_RS01450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TX50_RS01455	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
TX50_RS01460	COG0131	Imidazoleglycerol-phosphate dehydratase
TX50_RS01465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TX50_RS01480	COG0415	Belongs to the DNA photolyase family
TX50_RS01490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TX50_RS01495	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TX50_RS01495	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TX50_RS01505	COG1127	ABC transporter
TX50_RS01510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TX50_RS01515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS01520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS01525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS01530	COG1773	rubredoxin
TX50_RS01535	COG4447	cellulose binding
TX50_RS01555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TX50_RS01560	COG0709	Synthesizes selenophosphate from selenide and ATP
TX50_RS01565	COG0517	IMP dehydrogenase activity
TX50_RS01565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TX50_RS01565	COG0617	tRNA 3'-terminal CCA addition
TX50_RS01615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TX50_RS01620	COG0539	negative regulation of cytoplasmic translation
TX50_RS01625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TX50_RS01650	COG2890	protein-(glutamine-N5) methyltransferase activity
TX50_RS01655	COG0009	L-threonylcarbamoyladenylate synthase
TX50_RS01665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TX50_RS01670	COG2894	cell division
TX50_RS01675	COG0850	regulation of cytokinetic process
TX50_RS01680	COG1078	dGTPase activity
TX50_RS01685	COG0793	Belongs to the peptidase S41A family
TX50_RS01690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TX50_RS01695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TX50_RS01730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TX50_RS01740	COG0791	NLP P60 protein
TX50_RS01740	COG1388	LysM domain
TX50_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
TX50_RS01820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TX50_RS01830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX50_RS01850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TX50_RS01905	COG0351	phosphomethylpyrimidine kinase
TX50_RS01970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TX50_RS01975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TX50_RS01980	COG1116	anion transmembrane transporter activity
TX50_RS01985	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TX50_RS01990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TX50_RS02085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TX50_RS02105	COG1160	GTP binding
TX50_RS02110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TX50_RS02120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TX50_RS02125	COG1799	cell septum assembly
TX50_RS02130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TX50_RS02150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TX50_RS02155	COG0321	lipoyl(octanoyl) transferase activity
TX50_RS02160	COG1022	Amp-dependent synthetase and ligase
TX50_RS02180	COG0508	dehydrogenase complex catalyzes the overall conversion of
TX50_RS02185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TX50_RS02190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TX50_RS02195	COG0626	cystathionine gamma-synthase activity
TX50_RS02200	COG0626	cystathionine gamma-synthase activity
TX50_RS02205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TX50_RS02210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TX50_RS02220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TX50_RS02230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TX50_RS02250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TX50_RS02255	COG0579	oxidoreductase
TX50_RS02260	COG0481	GTPase activity
TX50_RS02270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX50_RS02290	COG3046	protein related to deoxyribodipyrimidine photolyase
TX50_RS02300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TX50_RS02300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TX50_RS02305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TX50_RS02310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TX50_RS02320	COG0107	imidazoleglycerol-phosphate synthase activity
TX50_RS02325	COG2226	methyltransferase
TX50_RS02335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TX50_RS02335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TX50_RS02340	COG0577	efflux transmembrane transporter activity
TX50_RS02340	COG1136	(ABC) transporter
TX50_RS02345	COG1007	ATP synthesis coupled electron transport
TX50_RS02350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TX50_RS02365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TX50_RS02390	COG1845	cytochrome c oxidase, subunit III
TX50_RS02410	COG0109	protoheme IX farnesyltransferase activity
TX50_RS02430	COG0459	protein refolding
TX50_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
TX50_RS02445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TX50_RS02450	COG1619	proteins homologs of microcin C7 resistance protein MccF
TX50_RS02455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TX50_RS02460	COG0248	Ppx GppA phosphatase
TX50_RS02475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TX50_RS02480	COG3258	Cytochrome c
TX50_RS02485	COG0723	plastoquinol--plastocyanin reductase activity
TX50_RS02495	COG0805	protein transport
TX50_RS02505	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TX50_RS02510	COG0194	GDP metabolic process
TX50_RS02525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TX50_RS02540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TX50_RS02560	COG0335	large ribosomal subunit rRNA binding
TX50_RS02570	COG0024	Methionine aminopeptidase
TX50_RS02575	COG3000	fatty acid hydroxylase
TX50_RS02575	COG0300	oxidoreductase activity
TX50_RS02580	COG0857	belongs to the CobB CobQ family
TX50_RS02590	COG1666	GTP binding
TX50_RS02605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TX50_RS02625	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TX50_RS02640	COG0523	cobalamin synthesis protein
TX50_RS02645	COG2154	pterin-4-alpha-carbinolamine dehydratase
TX50_RS02650	COG0432	Pfam Uncharacterised protein family UPF0047
TX50_RS02655	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TX50_RS02665	COG0181	hydroxymethylbilane synthase activity
TX50_RS02670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX50_RS02675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TX50_RS02685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TX50_RS02700	COG0629	single-stranded DNA binding
TX50_RS02715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX50_RS02720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TX50_RS02730	COG0442	prolyl-tRNA aminoacylation
TX50_RS02745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TX50_RS02750	COG1393	Belongs to the ArsC family
TX50_RS02755	COG0681	Belongs to the peptidase S26 family
TX50_RS02760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TX50_RS02765	COG0406	alpha-ribazole phosphatase activity
TX50_RS02780	COG0768	penicillin binding
TX50_RS02785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TX50_RS02795	COG0233	cytoplasmic translational termination
TX50_RS02800	COG0528	UMP kinase activity
TX50_RS02810	COG0582	viral genome integration into host DNA
TX50_RS02815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TX50_RS02820	COG0028	Belongs to the TPP enzyme family
TX50_RS02840	COG0539	negative regulation of cytoplasmic translation
TX50_RS02850	COG3396	Phenylacetate-CoA oxygenase
TX50_RS02855	COG5322	oxidoreductase activity
TX50_RS02860	COG0825	malonyl-CoA metabolic process
TX50_RS02865	COG4221	oxidoreductase activity
TX50_RS02870	COG0302	gtp cyclohydrolase
TX50_RS02875	COG0135	phosphoribosylanthranilate isomerase activity
TX50_RS02885	COG0095	Lipoate-protein ligase
TX50_RS02905	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TX50_RS02910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TX50_RS02915	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TX50_RS02925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TX50_RS02930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TX50_RS02935	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TX50_RS02940	COG1850	ribulose-bisphosphate carboxylase activity
TX50_RS02945	COG4451	ribulose bisphosphate carboxylase, small
TX50_RS02980	COG0251	oxidation-reduction process
TX50_RS02985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TX50_RS02990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TX50_RS02995	COG1132	(ABC) transporter
TX50_RS03000	COG0456	acetyltransferase
TX50_RS03015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TX50_RS03025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TX50_RS03035	COG0418	dihydroorotase activity
TX50_RS03055	COG0159	tryptophan synthase activity
TX50_RS03080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX50_RS03085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TX50_RS03085	COG0140	phosphoribosyl-ATP diphosphatase activity
TX50_RS03095	COG0542	response to heat
TX50_RS03100	COG3794	PFAM blue (type 1) copper domain protein
TX50_RS03110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TX50_RS03115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TX50_RS03145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TX50_RS03160	COG0339	signal peptide processing
TX50_RS03165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS03170	COG0083	homoserine kinase activity
TX50_RS03175	COG0837	glucose binding
TX50_RS03180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TX50_RS03185	COG0180	Tryptophanyl-tRNA synthetase
TX50_RS03205	COG1121	(ABC) transporter
TX50_RS03210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TX50_RS03225	COG0681	Belongs to the peptidase S26 family
TX50_RS03230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TX50_RS03240	COG0297	glycogen (starch) synthase activity
TX50_RS03245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TX50_RS03250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TX50_RS03255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TX50_RS03255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TX50_RS03260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TX50_RS03265	COG2045	Belongs to the ComB family
TX50_RS03275	COG2247	cell wall binding repeat
TX50_RS03275	COG0860	N-Acetylmuramoyl-L-alanine amidase
TX50_RS03285	COG0142	geranyltranstransferase activity
TX50_RS03290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TX50_RS03300	COG2176	DNA-directed DNA polymerase activity
TX50_RS03310	COG0124	histidyl-tRNA synthetase
TX50_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
TX50_RS03360	COG0644	oxidoreductase
TX50_RS03380	COG0735	belongs to the Fur family
TX50_RS03410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TX50_RS03415	COG0659	secondary active sulfate transmembrane transporter activity
TX50_RS03460	COG0346	lactoylglutathione lyase activity
TX50_RS03495	COG1187	pseudouridine synthase activity
TX50_RS03505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TX50_RS03525	COG4106	trans-aconitate 2-methyltransferase activity
TX50_RS03530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TX50_RS03540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TX50_RS03545	COG1122	ATPase activity
TX50_RS03560	COG1836	PFAM Integral membrane protein DUF92
TX50_RS03575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TX50_RS03580	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TX50_RS03585	COG0436	Aminotransferase
TX50_RS03590	COG1573	uracil-dna glycosylase
TX50_RS03595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TX50_RS03600	COG0793	Belongs to the peptidase S41A family
TX50_RS03605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TX50_RS03625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TX50_RS03630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TX50_RS03765	COG0745	RESPONSE REGULATOR receiver
TX50_RS03770	COG5002	protein histidine kinase activity
TX50_RS03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TX50_RS03795	COG2059	Chromate
TX50_RS03805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TX50_RS03810	COG0640	Transcriptional regulator
TX50_RS03825	COG0798	PFAM Bile acid sodium symporter
TX50_RS03865	COG0573	inorganic phosphate transmembrane transporter activity
TX50_RS03875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TX50_RS03890	COG1201	RNA secondary structure unwinding
TX50_RS03895	COG1793	dna ligase
TX50_RS03980	COG0740	serine-type endopeptidase activity
TX50_RS03985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX50_RS04000	COG0612	Peptidase, M16
TX50_RS04020	COG1136	(ABC) transporter
TX50_RS04025	COG1216	Glycosyl transferase, family 2
TX50_RS04030	COG0052	Belongs to the universal ribosomal protein uS2 family
TX50_RS04035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TX50_RS04045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TX50_RS04050	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TX50_RS04055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TX50_RS04060	COG0751	glycine-tRNA ligase activity
TX50_RS04065	COG0644	oxidoreductase
TX50_RS04075	COG1217	gtp-binding protein TYPA
TX50_RS04085	COG1137	ATPase activity
TX50_RS04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TX50_RS04095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TX50_RS04100	COG1494	fructose-1,6-bisphosphatase
TX50_RS04105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TX50_RS04110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TX50_RS04115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TX50_RS04120	COG0363	glucosamine-6-phosphate deaminase activity
TX50_RS04135	COG0129	dihydroxy-acid dehydratase activity
TX50_RS04145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TX50_RS04160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TX50_RS04165	COG0047	phosphoribosylformylglycinamidine synthase activity
TX50_RS04170	COG0191	fructose-bisphosphate aldolase activity
TX50_RS04175	COG0673	inositol 2-dehydrogenase activity
TX50_RS04185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TX50_RS04190	COG3954	Phosphoribulokinase
TX50_RS04195	COG0473	3-isopropylmalate dehydrogenase activity
TX50_RS04200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX50_RS04205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TX50_RS04220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TX50_RS04240	COG2197	response regulator
TX50_RS04245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TX50_RS04255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TX50_RS04275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TX50_RS04295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TX50_RS04305	COG1119	ATPase activity
TX50_RS04410	COG0799	negative regulation of ribosome biogenesis
TX50_RS04420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TX50_RS04430	COG1132	(ABC) transporter
TX50_RS04440	COG0149	triose-phosphate isomerase activity
TX50_RS04445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TX50_RS04450	COG1429	ligase activity, forming nitrogen-metal bonds
TX50_RS04455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TX50_RS04490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TX50_RS04495	COG0861	Integral membrane protein TerC family
TX50_RS04500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TX50_RS04510	COG0312	modulator of DNA gyrase
TX50_RS04515	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
TX50_RS04530	COG0557	exoribonuclease II activity
TX50_RS04540	COG2119	membrane
TX50_RS04560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TX50_RS04565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX50_RS04575	COG0450	alkyl hydroperoxide reductase
TX50_RS04615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TX50_RS04640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TX50_RS04645	COG0557	exoribonuclease II activity
TX50_RS04650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TX50_RS04655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TX50_RS04660	COG0072	phenylalanine-tRNA ligase activity
TX50_RS04690	COG1410	methionine synthase
TX50_RS04690	COG0646	methionine synthase
TX50_RS04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TX50_RS04710	COG1981	membrane
TX50_RS04715	COG0322	excinuclease ABC activity
TX50_RS04720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TX50_RS04720	COG0426	domain, Protein
TX50_RS04725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TX50_RS04740	COG1104	cysteine desulfurase activity
TX50_RS04745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TX50_RS04750	COG0495	leucyl-tRNA aminoacylation
TX50_RS04755	COG0166	Belongs to the GPI family
TX50_RS04760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TX50_RS04765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TX50_RS04770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TX50_RS04770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TX50_RS04775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX50_RS04785	COG0484	heat shock protein binding
TX50_RS04790	COG0443	Heat shock 70 kDa protein
TX50_RS04800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TX50_RS04805	COG0483	inositol monophosphate 1-phosphatase activity
TX50_RS04810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TX50_RS04815	COG0326	Molecular chaperone. Has ATPase activity
TX50_RS04820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TX50_RS04825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TX50_RS04845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TX50_RS04850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TX50_RS04870	COG0469	pyruvate kinase activity
TX50_RS04885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TX50_RS04890	COG1160	GTP binding
TX50_RS04895	COG0076	glutamate decarboxylase activity
TX50_RS04905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TX50_RS04910	COG0174	glutamine synthetase
TX50_RS04930	COG0515	serine threonine protein kinase
TX50_RS04935	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TX50_RS04945	COG0628	permease
TX50_RS04950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TX50_RS04955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TX50_RS04960	COG0022	dehydrogenase e1 component
TX50_RS04960	COG0508	dehydrogenase complex catalyzes the overall conversion of
TX50_RS04970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TX50_RS04975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TX50_RS04985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TX50_RS04990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TX50_RS04995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TX50_RS05005	COG0358	DNA primase activity
TX50_RS05020	COG0632	four-way junction helicase activity
TX50_RS05025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TX50_RS05035	COG0587	DNA-directed DNA polymerase activity
TX50_RS05040	COG0154	amidase activity
TX50_RS05050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX50_RS05055	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TX50_RS05060	COG0505	Belongs to the CarA family
TX50_RS05065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TX50_RS05075	COG1132	(ABC) transporter
TX50_RS05080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TX50_RS05090	COG1968	undecaprenyl-diphosphatase activity
TX50_RS05115	COG0366	Alpha amylase catalytic
TX50_RS05120	COG0463	Glycosyl transferase, family 2
TX50_RS05125	COG0804	urea catabolic process
TX50_RS05130	COG0832	Belongs to the urease beta subunit family
TX50_RS05135	COG0831	urea catabolic process
TX50_RS05140	COG0829	nickel cation binding
TX50_RS05145	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TX50_RS05150	COG0830	nickel cation binding
TX50_RS05155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TX50_RS05195	COG4555	ABC transporter
TX50_RS05265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TX50_RS05275	COG0572	uridine kinase
TX50_RS05300	COG3340	Belongs to the peptidase S51 family
TX50_RS05350	COG0308	aminopeptidase N
TX50_RS05370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TX50_RS05380	COG0386	Belongs to the glutathione peroxidase family
TX50_RS05395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TX50_RS05545	COG1121	(ABC) transporter
TX50_RS05555	COG0523	cobalamin synthesis protein
TX50_RS05580	COG2308	Evidence 4 Homologs of previously reported genes of
TX50_RS05615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TX50_RS05635	COG0601	transmembrane transport
TX50_RS05650	COG0460	homoserine dehydrogenase
TX50_RS05655	COG2166	iron-sulfur cluster assembly
TX50_RS05665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TX50_RS05670	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TX50_RS05675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TX50_RS05695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TX50_RS05700	COG3118	belongs to the thioredoxin family
TX50_RS05705	COG0516	GMP reductase activity
TX50_RS05710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TX50_RS05715	COG0644	oxidoreductase
TX50_RS05720	COG1543	Belongs to the glycosyl hydrolase 57 family
TX50_RS05725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TX50_RS05735	COG1480	7TM receptor with intracellular HD hydrolase
TX50_RS05740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TX50_RS05745	COG0142	geranyltranstransferase activity
TX50_RS05755	COG1797	cobyrinic acid a,c-diamide synthase activity
TX50_RS05765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TX50_RS05770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TX50_RS05785	COG2205	protein histidine kinase activity
TX50_RS05800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TX50_RS05805	COG1640	4-alpha-glucanotransferase
TX50_RS05815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX50_RS05820	COG1982	Orn Lys Arg decarboxylase major
TX50_RS05825	COG0575	Belongs to the CDS family
TX50_RS05835	COG0371	Dehydrogenase
TX50_RS05840	COG0542	response to heat
TX50_RS05850	COG0019	diaminopimelate decarboxylase activity
TX50_RS05855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TX50_RS05860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TX50_RS05865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TX50_RS05870	COG1054	Belongs to the UPF0176 family
TX50_RS05880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TX50_RS05885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TX50_RS05895	COG1132	(ABC) transporter
TX50_RS05905	COG0513	Belongs to the DEAD box helicase family
TX50_RS05910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TX50_RS05915	COG1074	ATP-dependent DNA helicase activity
TX50_RS05935	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TX50_RS05950	COG0271	Belongs to the BolA IbaG family
TX50_RS05955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TX50_RS05965	COG0745	RESPONSE REGULATOR receiver
TX50_RS05975	COG1233	COG1233 Phytoene dehydrogenase and related
TX50_RS05980	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TX50_RS06005	COG0457	Tetratricopeptide repeat
TX50_RS06015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TX50_RS06135	COG0012	GTP binding
TX50_RS06140	COG1566	PFAM secretion protein HlyD family protein
TX50_RS06145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TX50_RS06145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TX50_RS06150	COG0215	cysteine-tRNA ligase activity
TX50_RS06155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TX50_RS06160	COG3411	Ferredoxin
TX50_RS06165	COG0429	hydrolase of the alpha beta-hydrolase fold
TX50_RS06195	COG0492	ferredoxin-NADP+ reductase activity
TX50_RS06200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TX50_RS06210	COG0702	epimerase
TX50_RS06220	COG2267	carboxylic ester hydrolase activity
TX50_RS06225	COG0440	acetolactate synthase activity
TX50_RS06230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TX50_RS06250	COG0424	maF-like protein
TX50_RS06255	COG1492	cobalamin metabolic process
TX50_RS06290	COG1840	ABC-type Fe3 transport system, periplasmic component
TX50_RS06295	COG0752	glycyl-tRNA synthetase alpha subunit
TX50_RS06360	COG0438	transferase activity, transferring glycosyl groups
TX50_RS06365	COG0697	spore germination
TX50_RS06370	COG0616	signal peptide processing
TX50_RS06385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TX50_RS06390	COG0594	ribonuclease P activity
TX50_RS06400	COG0706	membrane insertase activity
TX50_RS06405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX50_RS06410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TX50_RS06415	COG0750	zinc metalloprotease
TX50_RS06420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TX50_RS06425	COG1185	polyribonucleotide nucleotidyltransferase activity
TX50_RS06430	COG1218	3'(2'),5'-bisphosphate nucleotidase
TX50_RS06435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TX50_RS06475	COG0463	Glycosyl transferase, family 2
TX50_RS06480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX50_RS06485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX50_RS06495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TX50_RS06510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX50_RS06515	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TX50_RS06520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TX50_RS06545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TX50_RS06550	COG0579	oxidoreductase
TX50_RS06555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TX50_RS06565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TX50_RS06565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TX50_RS06575	COG1216	Glycosyl transferase, family 2
TX50_RS06610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TX50_RS06620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TX50_RS06645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TX50_RS06650	COG3959	Transketolase, thiamine diphosphate binding domain
TX50_RS06655	COG3958	Transketolase
TX50_RS06670	COG1132	(ABC) transporter
TX50_RS06675	COG2226	methyltransferase
TX50_RS06690	COG2226	methyltransferase
TX50_RS06700	COG2192	nodulation
TX50_RS06725	COG2192	nodulation
TX50_RS06755	COG1216	Glycosyl transferase, family 2
TX50_RS06760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX50_RS06775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TX50_RS06780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TX50_RS06785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TX50_RS06790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TX50_RS06795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TX50_RS06800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX50_RS06800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TX50_RS06820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TX50_RS06825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TX50_RS06830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TX50_RS06840	COG0196	riboflavin kinase activity
TX50_RS06845	COG0352	thiamine-phosphate diphosphorylase activity
TX50_RS06855	COG1691	(AIR) carboxylase
TX50_RS06865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TX50_RS06870	COG0336	Belongs to the RNA methyltransferase TrmD family
TX50_RS06875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TX50_RS06890	COG1702	phosphate starvation-inducible protein PhoH
TX50_RS06895	COG0228	four-way junction DNA binding
TX50_RS06900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TX50_RS06910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TX50_RS06915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX50_RS06920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TX50_RS06920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TX50_RS06925	COG0482	sulfurtransferase activity
TX50_RS06930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TX50_RS06955	COG0134	indole-3-glycerol-phosphate synthase activity
TX50_RS06960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TX50_RS06965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TX50_RS06970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TX50_RS06975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TX50_RS06980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TX50_RS06985	COG0285	dihydrofolate synthase activity
TX50_RS07005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TX50_RS07010	COG1181	Belongs to the D-alanine--D-alanine ligase family
TX50_RS07025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TX50_RS07030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TX50_RS07035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TX50_RS07040	COG4956	integral membrane protein (PIN domain superfamily)
TX50_RS07045	COG0740	serine-type endopeptidase activity
TX50_RS07050	COG0740	serine-type endopeptidase activity
TX50_RS07055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TX50_RS07060	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TX50_RS07090	COG0776	regulation of translation
TX50_RS07105	COG2211	Major facilitator Superfamily
TX50_RS07110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TX50_RS07125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TX50_RS07130	COG0284	orotidine-5'-phosphate decarboxylase activity
TX50_RS07135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TX50_RS07150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TX50_RS07155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TX50_RS07165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TX50_RS07170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TX50_RS07175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TX50_RS07180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TX50_RS07185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TX50_RS07190	COG0151	Belongs to the GarS family
TX50_RS07195	COG5002	protein histidine kinase activity
TX50_RS07200	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TX50_RS07205	COG4251	negative regulation of phosphorylation
TX50_RS07210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TX50_RS07215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TX50_RS07220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TX50_RS07225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TX50_RS07230	COG2385	sporulation resulting in formation of a cellular spore
TX50_RS07235	COG1234	tRNA 3'-trailer cleavage
TX50_RS07255	COG2264	protein methyltransferase activity
TX50_RS07260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TX50_RS07320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TX50_RS07350	COG2081	HI0933 family
TX50_RS07395	COG0724	RNA recognition motif
TX50_RS07420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TX50_RS07425	COG2135	peptidase activity
TX50_RS07715	COG0443	Heat shock 70 kDa protein
TX50_RS07720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TX50_RS07725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TX50_RS07735	COG0459	protein refolding
TX50_RS07740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TX50_RS07745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TX50_RS07750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TX50_RS07760	COG0006	proline dipeptidase activity
TX50_RS07770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TX50_RS07775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TX50_RS07780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TX50_RS07780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TX50_RS07785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TX50_RS07795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TX50_RS07800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TX50_RS07805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TX50_RS07810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TX50_RS07815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TX50_RS07820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TX50_RS07825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TX50_RS07830	COG0356	it plays a direct role in the translocation of protons across the membrane
TX50_RS07840	COG0772	Belongs to the SEDS family
TX50_RS07845	COG0785	Cytochrome C biogenesis protein
TX50_RS07850	COG1333	cytochrome c biogenesis protein
TX50_RS07855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TX50_RS07865	COG0347	Belongs to the P(II) protein family
TX50_RS07870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TX50_RS07875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TX50_RS07880	COG0114	fumarate hydratase activity
TX50_RS07885	COG4581	dead DEAH box helicase
TX50_RS07905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TX50_RS07910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TX50_RS07925	COG0357	Ribosomal RNA small subunit methyltransferase G
TX50_RS07955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TX50_RS07965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TX50_RS07970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TX50_RS07975	COG0085	RNA polymerase activity
TX50_RS07980	COG0084	hydrolase, TatD family'
TX50_RS07985	COG0268	Binds directly to 16S ribosomal RNA
TX50_RS07990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TX50_RS07995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TX50_RS08000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TX50_RS08005	COG0779	Required for maturation of 30S ribosomal subunits
TX50_RS08010	COG0195	Participates in both transcription termination and antitermination
TX50_RS08020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TX50_RS08045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TX50_RS08050	COG0436	Aminotransferase
TX50_RS08055	COG1530	ribonuclease E activity
TX50_RS08060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TX50_RS08070	COG1605	Chorismate mutase
TX50_RS08070	COG0077	Prephenate dehydratase
TX50_RS08075	COG2226	methyltransferase
TX50_RS08080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TX50_RS08085	COG0051	transcription antitermination factor activity, RNA binding
TX50_RS08090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TX50_RS08095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TX50_RS08100	COG0049	tRNA binding
TX50_RS08105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TX50_RS08110	COG0070	glutamate synthase
TX50_RS08110	COG0069	glutamate synthase activity
TX50_RS08110	COG0067	glutamate synthase
TX50_RS08120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TX50_RS08160	COG0463	Glycosyl transferase, family 2
TX50_RS08165	COG2885	chlorophyll binding
TX50_RS08170	COG2885	chlorophyll binding
TX50_RS08190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TX50_RS08200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TX50_RS08205	COG0254	rRNA binding
TX50_RS08210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TX50_RS08215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TX50_RS08220	COG0101	tRNA pseudouridine synthase activity
TX50_RS08225	COG0203	ribosomal protein L17
TX50_RS08230	COG0202	RNA polymerase activity
TX50_RS08235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TX50_RS08240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TX50_RS08245	COG0563	adenylate kinase activity
TX50_RS08250	COG0201	protein transport
TX50_RS08255	COG0200	Binds to the 23S rRNA
TX50_RS08260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TX50_RS08265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TX50_RS08270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TX50_RS08275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TX50_RS08280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TX50_RS08285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TX50_RS08290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TX50_RS08295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TX50_RS08300	COG0255	Belongs to the universal ribosomal protein uL29 family
TX50_RS08305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TX50_RS08310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TX50_RS08315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TX50_RS08320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TX50_RS08325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TX50_RS08330	COG0089	rRNA binding
TX50_RS08335	COG0088	Forms part of the polypeptide exit tunnel
TX50_RS08340	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TX50_RS08365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TX50_RS08390	COG3001	Fructosamine kinase
TX50_RS08405	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TX50_RS08410	COG1606	tRNA processing
TX50_RS08415	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TX50_RS08420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TX50_RS08435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TX50_RS08445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TX50_RS08455	COG5002	protein histidine kinase activity
TX50_RS08460	COG0772	Belongs to the SEDS family
TX50_RS08465	COG0489	protein tyrosine kinase activity
TX50_RS08470	COG0408	coproporphyrinogen oxidase activity
TX50_RS08480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TX50_RS08505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TX50_RS08510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TX50_RS08510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TX50_RS08515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TX50_RS08530	COG5398	heme oxygenase
TX50_RS08540	COG0538	isocitrate dehydrogenase activity
TX50_RS08560	COG0475	glutathione-regulated potassium exporter activity
TX50_RS08565	COG0058	SHG alpha-glucan phosphorylase activity
TX50_RS08580	COG0571	ribonuclease III activity
TX50_RS08590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TX50_RS08595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TX50_RS08600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TX50_RS08605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TX50_RS08610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TX50_RS08615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TX50_RS08620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TX50_RS08630	COG1473	amidohydrolase
TX50_RS08640	COG2255	four-way junction helicase activity
TX50_RS08645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TX50_RS08655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TX50_RS08660	COG0745	RESPONSE REGULATOR receiver
TX50_RS08680	COG0629	single-stranded DNA binding
TX50_RS08685	COG0586	Pfam SNARE associated Golgi protein
TX50_RS08690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TX50_RS08695	COG0802	atpase or kinase
TX50_RS08710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX50_RS08715	COG2239	Acts as a magnesium transporter
TX50_RS08735	COG0187	DNA topoisomerase II activity
TX50_RS08735	COG1372	Participates in initiation and elongation during chromosome replication
TX50_RS08740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TX50_RS08745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TX50_RS08750	COG1725	Transcriptional regulator
TX50_RS08755	COG1045	serine acetyltransferase
TX50_RS08760	COG0653	protein targeting
TX50_RS08785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TX50_RS08795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TX50_RS08800	COG2082	Precorrin-8x methylmutase
TX50_RS08815	COG0556	nucleotide-excision repair
TX50_RS08825	COG0037	tRNA processing
TX50_RS08830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TX50_RS08835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TX50_RS08840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TX50_RS08845	COG0544	peptidyl-prolyl cis-trans isomerase activity
TX50_RS08850	COG0740	serine-type endopeptidase activity
TX50_RS08855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TX50_RS08860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TX50_RS08865	COG1215	transferase activity, transferring glycosyl groups
TX50_RS08870	COG2385	sporulation resulting in formation of a cellular spore
TX50_RS08875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TX50_RS08880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TX50_RS08890	COG2022	thiamine diphosphate biosynthetic process
TX50_RS08895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TX50_RS08900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TX50_RS08900	COG0438	transferase activity, transferring glycosyl groups
TX50_RS08910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TX50_RS08910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TX50_RS08915	COG0509	glycine decarboxylation via glycine cleavage system
TX50_RS08920	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TX50_RS08935	COG0359	binds to the 23S rRNA
TX50_RS08940	COG0305	Participates in initiation and elongation during chromosome replication
TX50_RS08940	COG1372	Participates in initiation and elongation during chromosome replication
TX50_RS08940	COG0305	Participates in initiation and elongation during chromosome replication
TX50_RS08940	COG1372	Participates in initiation and elongation during chromosome replication
TX50_RS08945	COG0445	tRNA wobble uridine modification
TX50_RS08975	COG0398	Pfam SNARE associated Golgi protein
TX50_RS08980	COG0525	valine-tRNA ligase activity
TX50_RS08995	COG3956	TIGRFAM MazG family protein
TX50_RS09000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TX50_RS09010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TX50_RS09015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TX50_RS09020	COG0504	CTP synthase activity
TX50_RS09025	COG0602	queuosine metabolic process
TX50_RS09030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TX50_RS09035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TX50_RS09045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TX50_RS09055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TX50_RS09060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TX50_RS09065	COG0170	dolichyl monophosphate biosynthetic process
TX50_RS09070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TX50_RS09075	COG1049	propionate catabolic process, 2-methylcitrate cycle
TX50_RS09080	COG0038	chloride channel
TX50_RS09085	COG0788	formyltetrahydrofolate deformylase activity
TX50_RS09095	COG0443	Heat shock 70 kDa protein
TX50_RS09100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TX50_RS09105	COG0360	Binds together with S18 to 16S ribosomal RNA
TX50_RS09110	COG0137	argininosuccinate synthase activity
TX50_RS09125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TX50_RS09135	COG0438	transferase activity, transferring glycosyl groups
TX50_RS09140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TX50_RS09145	COG0497	DNA recombination
TX50_RS09150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TX50_RS09160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TX50_RS09215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain