locus-tag	class	description
GM418_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GM418_RS00015	COG1739	Uncharacterized protein family UPF0029
GM418_RS00020	COG0540	Belongs to the ATCase OTCase family
GM418_RS00025	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GM418_RS00040	COG4977	sequence-specific DNA binding
GM418_RS00040	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS00045	COG5012	cobalamin binding
GM418_RS00055	COG0523	cobalamin synthesis protein
GM418_RS00065	COG3507	Belongs to the glycosyl hydrolase 43 family
GM418_RS00075	COG0386	Belongs to the glutathione peroxidase family
GM418_RS00095	COG0673	inositol 2-dehydrogenase activity
GM418_RS00130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GM418_RS00145	COG0612	Peptidase, M16
GM418_RS00150	COG0561	phosphatase activity
GM418_RS00205	COG1730	sister chromatid segregation
GM418_RS00245	COG1301	dicarboxylic acid transport
GM418_RS00250	COG3275	phosphorelay sensor kinase activity
GM418_RS00255	COG3279	Response regulator of the LytR AlgR family
GM418_RS00275	COG0552	protein localization to endoplasmic reticulum
GM418_RS00285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GM418_RS00290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GM418_RS00305	COG4585	Histidine kinase
GM418_RS00325	COG0450	alkyl hydroperoxide reductase
GM418_RS00345	COG2010	Cytochrome c
GM418_RS00345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GM418_RS00350	COG2080	2 iron, 2 sulfur cluster binding
GM418_RS00355	COG0475	glutathione-regulated potassium exporter activity
GM418_RS00365	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM418_RS00420	COG0432	Pfam Uncharacterised protein family UPF0047
GM418_RS00425	COG0432	Pfam Uncharacterised protein family UPF0047
GM418_RS00445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GM418_RS00455	COG1484	DNA-dependent DNA replication
GM418_RS00460	COG4584	PFAM Integrase catalytic
GM418_RS00470	COG0432	Pfam Uncharacterised protein family UPF0047
GM418_RS00495	COG1506	peptidase
GM418_RS00495	COG4946	Tricorn protease homolog
GM418_RS00495	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS00500	COG0534	Mate efflux family protein
GM418_RS00530	COG1132	(ABC) transporter
GM418_RS00535	COG1132	(ABC) transporter
GM418_RS00605	COG1629	transport
GM418_RS00605	COG4206	TonB-dependent receptor
GM418_RS00615	COG0456	acetyltransferase
GM418_RS00635	COG4993	Dehydrogenase
GM418_RS00680	COG1629	transport
GM418_RS00680	COG4206	TonB-dependent receptor
GM418_RS00710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GM418_RS00720	COG1940	carbohydrate kinase activity
GM418_RS00725	COG1349	DNA-binding transcription factor activity
GM418_RS00740	COG1629	transport
GM418_RS00740	COG4206	TonB-dependent receptor
GM418_RS00755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GM418_RS00795	COG2169	Transcriptional regulator
GM418_RS00830	COG2267	carboxylic ester hydrolase activity
GM418_RS00840	COG1181	Belongs to the D-alanine--D-alanine ligase family
GM418_RS00855	COG0446	pyridine nucleotide-disulphide oxidoreductase
GM418_RS00860	COG3384	dioxygenase
GM418_RS00885	COG3537	Alpha-1,2-mannosidase
GM418_RS00910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS00950	COG3118	belongs to the thioredoxin family
GM418_RS00985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GM418_RS00985	COG2207	Transcriptional regulator
GM418_RS00990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM418_RS00995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GM418_RS01030	COG2885	chlorophyll binding
GM418_RS01030	COG3047	cAMP biosynthetic process
GM418_RS01045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GM418_RS01055	COG0628	permease
GM418_RS01070	COG3237	CsbD-like
GM418_RS01100	COG2204	response regulator
GM418_RS01115	COG1127	ABC transporter
GM418_RS01120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GM418_RS01140	COG0668	transmembrane transport
GM418_RS01155	COG1929	Belongs to the glycerate kinase type-1 family
GM418_RS01160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GM418_RS01165	COG1528	Iron-storage protein
GM418_RS01175	COG2382	esterase
GM418_RS01185	COG3119	arylsulfatase activity
GM418_RS01190	COG3119	arylsulfatase activity
GM418_RS01205	COG2813	Specifically methylates the guanine in position
GM418_RS01215	COG1272	protein, Hemolysin III
GM418_RS01220	COG1070	Carbohydrate kinase
GM418_RS01230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GM418_RS01235	COG2193	ferroxidase activity
GM418_RS01245	COG0667	Aldo Keto reductase
GM418_RS01250	COG3119	arylsulfatase activity
GM418_RS01265	COG1629	transport
GM418_RS01265	COG4206	TonB-dependent receptor
GM418_RS01275	COG5434	Belongs to the glycosyl hydrolase 28 family
GM418_RS01320	COG3011	Protein conserved in bacteria
GM418_RS01330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GM418_RS01335	COG0193	aminoacyl-tRNA hydrolase activity
GM418_RS01340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GM418_RS01345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GM418_RS01350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GM418_RS01355	COG1482	cell wall glycoprotein biosynthetic process
GM418_RS01365	COG0572	uridine kinase
GM418_RS01380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GM418_RS01390	COG0556	nucleotide-excision repair
GM418_RS01430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS01455	COG0129	dihydroxy-acid dehydratase activity
GM418_RS01460	COG0028	Belongs to the TPP enzyme family
GM418_RS01470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GM418_RS01475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM418_RS01490	COG2226	methyltransferase
GM418_RS01495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GM418_RS01545	COG4628	conserved protein (DUF2132)
GM418_RS01555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GM418_RS01560	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GM418_RS01565	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GM418_RS01585	COG2205	protein histidine kinase activity
GM418_RS01620	COG4206	TonB-dependent receptor
GM418_RS01620	COG1629	transport
GM418_RS01630	COG2211	Major facilitator Superfamily
GM418_RS01645	COG0071	Belongs to the small heat shock protein (HSP20) family
GM418_RS01650	COG0714	Associated with various cellular activities
GM418_RS01670	COG2304	oxidoreductase activity
GM418_RS01700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GM418_RS01710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GM418_RS01715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GM418_RS01735	COG4206	TonB-dependent receptor
GM418_RS01735	COG1629	transport
GM418_RS01745	COG3119	arylsulfatase activity
GM418_RS01760	COG1629	transport
GM418_RS01760	COG4206	TonB-dependent receptor
GM418_RS01785	COG1966	Carbon starvation protein
GM418_RS01795	COG0363	glucosamine-6-phosphate deaminase activity
GM418_RS01800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GM418_RS01825	COG1194	a g-specific adenine glycosylase
GM418_RS01830	COG0776	regulation of translation
GM418_RS01835	COG1530	ribonuclease E activity
GM418_RS01840	COG4232	protein-disulfide reductase activity
GM418_RS01870	COG0247	lactate metabolic process
GM418_RS01875	COG1132	(ABC) transporter
GM418_RS01885	COG1030	water channel activity
GM418_RS01900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM418_RS01930	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GM418_RS01945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM418_RS01955	COG3655	Transcriptional regulator
GM418_RS01980	COG1215	transferase activity, transferring glycosyl groups
GM418_RS02045	COG1082	Xylose isomerase domain protein TIM barrel
GM418_RS02060	COG1629	transport
GM418_RS02060	COG4206	TonB-dependent receptor
GM418_RS02070	COG3119	arylsulfatase activity
GM418_RS02110	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS02110	COG4977	sequence-specific DNA binding
GM418_RS02125	COG0667	Aldo Keto reductase
GM418_RS02130	COG0702	epimerase
GM418_RS02145	COG0656	L-ascorbic acid biosynthetic process
GM418_RS02155	COG0071	Belongs to the small heat shock protein (HSP20) family
GM418_RS02160	COG0336	Belongs to the RNA methyltransferase TrmD family
GM418_RS02170	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GM418_RS02180	COG0405	Gamma-glutamyltransferase
GM418_RS02205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GM418_RS02235	COG0513	Belongs to the DEAD box helicase family
GM418_RS02250	COG0235	Class ii aldolase
GM418_RS02255	COG4806	L-rhamnose isomerase
GM418_RS02265	COG3254	rhamnose metabolic process
GM418_RS02295	COG1136	(ABC) transporter
GM418_RS02350	COG4974	Belongs to the 'phage' integrase family
GM418_RS02375	COG3119	arylsulfatase activity
GM418_RS02380	COG3119	arylsulfatase activity
GM418_RS02395	COG4206	TonB-dependent receptor
GM418_RS02395	COG1629	transport
GM418_RS02435	COG0738	Major facilitator superfamily
GM418_RS02445	COG3119	arylsulfatase activity
GM418_RS02450	COG3119	arylsulfatase activity
GM418_RS02465	COG3119	arylsulfatase activity
GM418_RS02470	COG3119	arylsulfatase activity
GM418_RS02480	COG3119	arylsulfatase activity
GM418_RS02485	COG3119	arylsulfatase activity
GM418_RS02500	COG3119	arylsulfatase activity
GM418_RS02510	COG1629	transport
GM418_RS02510	COG4206	TonB-dependent receptor
GM418_RS02520	COG1595	DNA-templated transcription, initiation
GM418_RS02540	COG3119	arylsulfatase activity
GM418_RS02550	COG1629	transport
GM418_RS02550	COG4206	TonB-dependent receptor
GM418_RS02620	COG3119	arylsulfatase activity
GM418_RS02630	COG5492	domain, Protein
GM418_RS02650	COG5492	domain, Protein
GM418_RS02670	COG5434	Belongs to the glycosyl hydrolase 28 family
GM418_RS02680	COG1629	transport
GM418_RS02680	COG4206	TonB-dependent receptor
GM418_RS02690	COG0427	acetyl-CoA hydrolase
GM418_RS02700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GM418_RS02705	COG2223	nitrite transmembrane transporter activity
GM418_RS02710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GM418_RS02710	COG1042	CoA-binding domain protein
GM418_RS02710	COG0045	succinate-CoA ligase (ADP-forming) activity
GM418_RS02715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GM418_RS02720	COG0793	Belongs to the peptidase S41A family
GM418_RS02720	COG4946	Tricorn protease homolog
GM418_RS02730	COG2271	Major facilitator Superfamily
GM418_RS02740	COG1629	transport
GM418_RS02740	COG4206	TonB-dependent receptor
GM418_RS02745	COG0561	phosphatase activity
GM418_RS02765	COG3119	arylsulfatase activity
GM418_RS02780	COG0277	FAD linked oxidase domain protein
GM418_RS02780	COG0247	lactate metabolic process
GM418_RS02815	COG0456	acetyltransferase
GM418_RS02845	COG3956	TIGRFAM MazG family protein
GM418_RS02860	COG1595	DNA-templated transcription, initiation
GM418_RS02875	COG1702	phosphate starvation-inducible protein PhoH
GM418_RS02880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GM418_RS02885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS02890	COG1404	Belongs to the peptidase S8 family
GM418_RS02905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GM418_RS02920	COG0302	gtp cyclohydrolase
GM418_RS02970	COG0463	Glycosyl transferase, family 2
GM418_RS02995	COG0519	Catalyzes the synthesis of GMP from XMP
GM418_RS03010	COG1741	Belongs to the pirin family
GM418_RS03020	COG3040	lipid binding
GM418_RS03035	COG2942	2-epimerase
GM418_RS03040	COG0673	inositol 2-dehydrogenase activity
GM418_RS03045	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GM418_RS03055	COG0673	inositol 2-dehydrogenase activity
GM418_RS03100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GM418_RS03120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS03125	COG1136	(ABC) transporter
GM418_RS03130	COG1136	(ABC) transporter
GM418_RS03130	COG0577	efflux transmembrane transporter activity
GM418_RS03140	COG3279	Response regulator of the LytR AlgR family
GM418_RS03160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GM418_RS03195	COG2207	Transcriptional regulator
GM418_RS03195	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS03200	COG0277	FAD linked oxidase domain protein
GM418_RS03225	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS03235	COG1609	Transcriptional regulator
GM418_RS03240	COG0587	DNA-directed DNA polymerase activity
GM418_RS03245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GM418_RS03275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GM418_RS03285	COG2814	Major facilitator Superfamily
GM418_RS03290	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS03290	COG4977	sequence-specific DNA binding
GM418_RS03345	COG0656	L-ascorbic acid biosynthetic process
GM418_RS03355	COG1942	4-Oxalocrotonate Tautomerase
GM418_RS03400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GM418_RS03405	COG0431	NADPH-dependent FMN reductase
GM418_RS03430	COG0047	phosphoribosylformylglycinamidine synthase activity
GM418_RS03430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GM418_RS03445	COG0693	protein deglycase activity
GM418_RS03470	COG2244	polysaccharide biosynthetic process
GM418_RS03480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GM418_RS03515	COG4206	TonB-dependent receptor
GM418_RS03535	COG0018	arginyl-trna synthetase
GM418_RS03560	COG2272	Belongs to the type-B carboxylesterase lipase family
GM418_RS03565	COG2272	Belongs to the type-B carboxylesterase lipase family
GM418_RS03590	COG0745	RESPONSE REGULATOR receiver
GM418_RS03595	COG2770	Histidine kinase
GM418_RS03595	COG2205	protein histidine kinase activity
GM418_RS03600	COG3111	PFAM Bacterial OB fold (BOF) protein
GM418_RS03605	COG1971	Probably functions as a manganese efflux pump
GM418_RS03635	COG0657	acetylesterase activity
GM418_RS03635	COG2755	lipolytic protein G-D-S-L family
GM418_RS03670	COG0584	glycerophosphoryl diester phosphodiesterase
GM418_RS03690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GM418_RS03695	COG4206	TonB-dependent receptor
GM418_RS03695	COG1629	transport
GM418_RS03720	COG1629	transport
GM418_RS03720	COG4206	TonB-dependent receptor
GM418_RS03740	COG3537	Alpha-1,2-mannosidase
GM418_RS03760	COG4206	TonB-dependent receptor
GM418_RS03760	COG1629	transport
GM418_RS03785	COG0538	isocitrate dehydrogenase activity
GM418_RS03790	COG0538	isocitrate dehydrogenase activity
GM418_RS03820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GM418_RS03830	COG0203	ribosomal protein L17
GM418_RS03835	COG0202	RNA polymerase activity
GM418_RS03840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GM418_RS03845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GM418_RS03850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GM418_RS03855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GM418_RS03860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GM418_RS03870	COG0201	protein transport
GM418_RS03875	COG0200	Binds to the 23S rRNA
GM418_RS03880	COG1841	ribosomal large subunit assembly
GM418_RS03885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GM418_RS03890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GM418_RS03895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GM418_RS03900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GM418_RS03905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GM418_RS03910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GM418_RS03915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GM418_RS03920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GM418_RS03925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GM418_RS03930	COG0255	Belongs to the universal ribosomal protein uL29 family
GM418_RS03935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GM418_RS03940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GM418_RS03950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GM418_RS03955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GM418_RS03960	COG0089	rRNA binding
GM418_RS03965	COG0088	Forms part of the polypeptide exit tunnel
GM418_RS03970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GM418_RS03975	COG0051	transcription antitermination factor activity, RNA binding
GM418_RS03980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM418_RS03985	COG0049	tRNA binding
GM418_RS03990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GM418_RS03995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS04015	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS04055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM418_RS04060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GM418_RS04065	COG3119	arylsulfatase activity
GM418_RS04070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GM418_RS04085	COG0542	response to heat
GM418_RS04090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GM418_RS04090	COG0574	Belongs to the PEP-utilizing enzyme family
GM418_RS04095	COG2197	response regulator
GM418_RS04100	COG4585	Histidine kinase
GM418_RS04125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GM418_RS04130	COG0242	peptide deformylase activity
GM418_RS04135	COG0658	competence protein
GM418_RS04135	COG2333	competence protein COMEC
GM418_RS04140	COG0569	domain protein
GM418_RS04145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GM418_RS04150	COG0009	L-threonylcarbamoyladenylate synthase
GM418_RS04155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GM418_RS04155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GM418_RS04160	COG0545	Peptidyl-prolyl cis-trans isomerase
GM418_RS04175	COG3022	response to hydroperoxide
GM418_RS04185	COG4251	negative regulation of phosphorylation
GM418_RS04205	COG0386	Belongs to the glutathione peroxidase family
GM418_RS04210	COG1846	Transcriptional regulator
GM418_RS04240	COG4953	penicillin-binding protein 1C
GM418_RS04255	COG2249	NAD(P)H dehydrogenase (quinone) activity
GM418_RS04270	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
GM418_RS04270	COG2878	Part of a membrane complex involved in electron transport
GM418_RS04275	COG4656	Part of a membrane complex involved in electron transport
GM418_RS04280	COG4658	electron transport chain
GM418_RS04285	COG4659	FMN binding
GM418_RS04290	COG4660	Part of a membrane complex involved in electron transport
GM418_RS04295	COG4657	Part of a membrane complex involved in electron transport
GM418_RS04300	COG0535	radical SAM domain protein
GM418_RS04310	COG1794	racemase activity, acting on amino acids and derivatives
GM418_RS04330	COG1595	DNA-templated transcription, initiation
GM418_RS04355	COG0659	secondary active sulfate transmembrane transporter activity
GM418_RS04370	COG3279	Response regulator of the LytR AlgR family
GM418_RS04405	COG2226	methyltransferase
GM418_RS04425	COG1228	amidohydrolase
GM418_RS04440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GM418_RS04445	COG0488	(ABC) transporter
GM418_RS04455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GM418_RS04460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GM418_RS04465	COG2183	response to ionizing radiation
GM418_RS04480	COG1115	amino acid carrier protein
GM418_RS04495	COG1193	negative regulation of DNA recombination
GM418_RS04500	COG2154	pterin-4-alpha-carbinolamine dehydratase
GM418_RS04510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GM418_RS04525	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM418_RS04530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS04570	COG1012	belongs to the aldehyde dehydrogenase family
GM418_RS04590	COG1764	response to oxidative stress
GM418_RS04605	COG2204	response regulator
GM418_RS04615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GM418_RS04645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GM418_RS04650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS04655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GM418_RS04675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM418_RS04680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GM418_RS04685	COG1335	isochorismatase
GM418_RS04730	COG0426	domain, Protein
GM418_RS04740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GM418_RS04775	COG0438	transferase activity, transferring glycosyl groups
GM418_RS04780	COG2884	Cell division ATP-binding protein ftsE
GM418_RS04795	COG0187	DNA topoisomerase II activity
GM418_RS04800	COG1611	Belongs to the LOG family
GM418_RS04805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GM418_RS04810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM418_RS04815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GM418_RS04820	COG0488	(ABC) transporter
GM418_RS04825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GM418_RS04830	COG1522	sequence-specific DNA binding
GM418_RS04835	COG0004	ammonium transporteR
GM418_RS04840	COG1522	sequence-specific DNA binding
GM418_RS04845	COG0668	transmembrane transport
GM418_RS04860	COG1595	DNA-templated transcription, initiation
GM418_RS04875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS04885	COG0302	gtp cyclohydrolase
GM418_RS04890	COG2706	6-phosphogluconolactonase activity
GM418_RS04905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GM418_RS04905	COG1773	rubredoxin
GM418_RS04915	COG2204	response regulator
GM418_RS04925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GM418_RS04930	COG0586	Pfam SNARE associated Golgi protein
GM418_RS04935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GM418_RS04965	COG1252	NADH dehydrogenase
GM418_RS04970	COG2308	Evidence 4 Homologs of previously reported genes of
GM418_RS04980	COG1305	Transglutaminase-like
GM418_RS05005	COG0438	transferase activity, transferring glycosyl groups
GM418_RS05075	COG3279	Response regulator of the LytR AlgR family
GM418_RS05080	COG3275	phosphorelay sensor kinase activity
GM418_RS05110	COG1012	belongs to the aldehyde dehydrogenase family
GM418_RS05125	COG0628	permease
GM418_RS05135	COG2195	Cleaves the N-terminal amino acid of tripeptides
GM418_RS05160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GM418_RS05165	COG2249	NAD(P)H dehydrogenase (quinone) activity
GM418_RS05195	COG1733	regulation of RNA biosynthetic process
GM418_RS05215	COG5002	protein histidine kinase activity
GM418_RS05235	COG1960	acyl-CoA dehydrogenase activity
GM418_RS05240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GM418_RS05245	COG2086	electron transfer activity
GM418_RS05260	COG0085	RNA polymerase activity
GM418_RS05265	COG0222	ribosome binding
GM418_RS05270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GM418_RS05275	COG0081	regulation of translation
GM418_RS05280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GM418_RS05295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GM418_RS05310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GM418_RS05315	COG4974	Belongs to the 'phage' integrase family
GM418_RS05320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GM418_RS05330	COG0733	neurotransmitter:sodium symporter activity
GM418_RS05340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GM418_RS05350	COG2226	methyltransferase
GM418_RS05355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GM418_RS05360	COG4221	oxidoreductase activity
GM418_RS05370	COG3275	phosphorelay sensor kinase activity
GM418_RS05375	COG3279	Response regulator of the LytR AlgR family
GM418_RS05390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GM418_RS05395	COG1136	(ABC) transporter
GM418_RS05395	COG0577	efflux transmembrane transporter activity
GM418_RS05405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GM418_RS05415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GM418_RS05425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GM418_RS05430	COG0735	belongs to the Fur family
GM418_RS05435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GM418_RS05440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GM418_RS05455	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS05455	COG1506	peptidase
GM418_RS05485	COG0142	geranyltranstransferase activity
GM418_RS05510	COG2195	Cleaves the N-terminal amino acid of tripeptides
GM418_RS05515	COG3104	oligopeptide transport
GM418_RS05525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GM418_RS05525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GM418_RS05530	COG3104	oligopeptide transport
GM418_RS05550	COG1082	Xylose isomerase domain protein TIM barrel
GM418_RS05570	COG0702	epimerase
GM418_RS05575	COG3401	FG-GAP repeat protein
GM418_RS05600	COG1022	Amp-dependent synthetase and ligase
GM418_RS05605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GM418_RS05605	COG1333	cytochrome c biogenesis protein
GM418_RS05620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GM418_RS05625	COG0739	heme binding
GM418_RS05635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GM418_RS05655	COG1704	LemA family
GM418_RS05660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GM418_RS05675	COG3279	Response regulator of the LytR AlgR family
GM418_RS05700	COG0534	Mate efflux family protein
GM418_RS05715	COG2172	sigma factor antagonist activity
GM418_RS05760	COG0254	rRNA binding
GM418_RS05765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GM418_RS05770	COG3250	beta-galactosidase activity
GM418_RS05810	COG3239	Fatty acid desaturase
GM418_RS05900	COG2010	Cytochrome c
GM418_RS05900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GM418_RS05950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GM418_RS05955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GM418_RS05965	COG0445	tRNA wobble uridine modification
GM418_RS05980	COG0248	Ppx GppA phosphatase
GM418_RS05985	COG0109	protoheme IX farnesyltransferase activity
GM418_RS06035	COG3278	Belongs to the heme-copper respiratory oxidase family
GM418_RS06065	COG2217	Heavy metal translocating P-type atpase
GM418_RS06075	COG1271	oxidase subunit
GM418_RS06105	COG0463	Glycosyl transferase, family 2
GM418_RS06140	COG0463	Glycosyl transferase, family 2
GM418_RS06145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GM418_RS06155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GM418_RS06165	COG1051	belongs to the nudix hydrolase family
GM418_RS06170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GM418_RS06180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GM418_RS06180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GM418_RS06185	COG0799	negative regulation of ribosome biogenesis
GM418_RS06190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GM418_RS06205	COG4589	Belongs to the CDS family
GM418_RS06210	COG0688	phosphatidylethanolamine metabolic process
GM418_RS06215	COG1183	phosphatidylcholine synthase activity
GM418_RS06245	COG3301	Polysulphide reductase, NrfD
GM418_RS06250	COG0437	4 iron, 4 sulfur cluster binding
GM418_RS06275	COG2920	part of a sulfur-relay system
GM418_RS06290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM418_RS06295	COG0746	molybdenum cofactor guanylyltransferase activity
GM418_RS06310	COG1595	DNA-templated transcription, initiation
GM418_RS06350	COG1509	lysine 2,3-aminomutase activity
GM418_RS06355	COG0456	acetyltransferase
GM418_RS06370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS06375	COG0697	spore germination
GM418_RS06400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GM418_RS06405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GM418_RS06410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GM418_RS06415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GM418_RS06415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GM418_RS06420	COG1192	Involved in chromosome partitioning
GM418_RS06425	COG1475	DNA binding
GM418_RS06435	COG0741	lytic transglycosylase activity
GM418_RS06450	COG0784	Response regulator, receiver
GM418_RS06450	COG2198	Histidine kinase
GM418_RS06450	COG5002	protein histidine kinase activity
GM418_RS06455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GM418_RS06460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GM418_RS06465	COG0534	Mate efflux family protein
GM418_RS06470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GM418_RS06495	COG3119	arylsulfatase activity
GM418_RS06500	COG3119	arylsulfatase activity
GM418_RS06510	COG1629	transport
GM418_RS06510	COG4206	TonB-dependent receptor
GM418_RS06530	COG3153	acetyltransferase
GM418_RS06565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GM418_RS06585	COG0584	glycerophosphoryl diester phosphodiesterase
GM418_RS06610	COG4771	TonB-dependent receptor
GM418_RS06635	COG3279	Response regulator of the LytR AlgR family
GM418_RS06640	COG3275	phosphorelay sensor kinase activity
GM418_RS06655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GM418_RS06680	COG1629	transport
GM418_RS06680	COG4206	TonB-dependent receptor
GM418_RS06690	COG0531	amino acid
GM418_RS06710	COG0783	Belongs to the Dps family
GM418_RS06750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GM418_RS06770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GM418_RS06775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GM418_RS06790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GM418_RS06795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GM418_RS06800	COG0772	Belongs to the SEDS family
GM418_RS06805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GM418_RS06810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GM418_RS06815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GM418_RS06830	COG0275	rRNA processing
GM418_RS06835	COG2001	Belongs to the MraZ family
GM418_RS06855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GM418_RS06865	COG0217	transcriptional regulatory protein
GM418_RS06875	COG1691	(AIR) carboxylase
GM418_RS06880	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GM418_RS06885	COG1606	tRNA processing
GM418_RS06890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM418_RS06905	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GM418_RS06925	COG4999	Histidine kinase
GM418_RS06925	COG3437	response regulator, receiver
GM418_RS06925	COG2205	protein histidine kinase activity
GM418_RS06925	COG3850	Histidine kinase
GM418_RS06930	COG1785	Belongs to the alkaline phosphatase family
GM418_RS06945	COG4335	DNA alkylation repair
GM418_RS06950	COG1131	(ABC) transporter
GM418_RS06955	COG0513	Belongs to the DEAD box helicase family
GM418_RS06960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GM418_RS06960	COG0758	DNA mediated transformation
GM418_RS06970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GM418_RS06980	COG0590	tRNA wobble adenosine to inosine editing
GM418_RS06985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GM418_RS07005	COG0811	peptide transport
GM418_RS07015	COG0252	asparaginase activity
GM418_RS07020	COG0084	hydrolase, TatD family'
GM418_RS07030	COG0459	protein refolding
GM418_RS07035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GM418_RS07060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GM418_RS07070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GM418_RS07085	COG4206	TonB-dependent receptor
GM418_RS07100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GM418_RS07110	COG2188	Transcriptional regulator
GM418_RS07115	COG0667	Aldo Keto reductase
GM418_RS07125	COG0481	GTPase activity
GM418_RS07145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM418_RS07150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GM418_RS07155	COG0571	ribonuclease III activity
GM418_RS07175	COG3275	phosphorelay sensor kinase activity
GM418_RS07180	COG3279	Response regulator of the LytR AlgR family
GM418_RS07185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GM418_RS07210	COG1629	transport
GM418_RS07210	COG4206	TonB-dependent receptor
GM418_RS07280	COG1629	transport
GM418_RS07280	COG4206	TonB-dependent receptor
GM418_RS07290	COG3119	arylsulfatase activity
GM418_RS07315	COG1629	transport
GM418_RS07315	COG4206	TonB-dependent receptor
GM418_RS07330	COG1595	DNA-templated transcription, initiation
GM418_RS07340	COG4206	TonB-dependent receptor
GM418_RS07340	COG1629	transport
GM418_RS07350	COG3119	arylsulfatase activity
GM418_RS07360	COG3119	arylsulfatase activity
GM418_RS07375	COG1595	DNA-templated transcription, initiation
GM418_RS07385	COG1629	transport
GM418_RS07385	COG4206	TonB-dependent receptor
GM418_RS07395	COG3119	arylsulfatase activity
GM418_RS07400	COG3119	arylsulfatase activity
GM418_RS07405	COG3119	arylsulfatase activity
GM418_RS07455	COG4206	TonB-dependent receptor
GM418_RS07455	COG1629	transport
GM418_RS07470	COG3119	arylsulfatase activity
GM418_RS07475	COG2211	Major facilitator Superfamily
GM418_RS07480	COG3119	arylsulfatase activity
GM418_RS07485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GM418_RS07490	COG3938	Belongs to the proline racemase family
GM418_RS07500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GM418_RS07515	COG4447	cellulose binding
GM418_RS07530	COG4206	TonB-dependent receptor
GM418_RS07530	COG1629	transport
GM418_RS07540	COG3119	arylsulfatase activity
GM418_RS07545	COG3119	arylsulfatase activity
GM418_RS07555	COG3119	arylsulfatase activity
GM418_RS07625	COG1132	(ABC) transporter
GM418_RS07635	COG1073	alpha beta
GM418_RS07640	COG1914	H( )-stimulated, divalent metal cation uptake system
GM418_RS07650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GM418_RS07655	COG0052	Belongs to the universal ribosomal protein uS2 family
GM418_RS07660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GM418_RS07665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GM418_RS07670	COG2177	Part of the ABC transporter FtsEX involved in
GM418_RS07680	COG1968	undecaprenyl-diphosphatase activity
GM418_RS07685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GM418_RS07690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GM418_RS07710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GM418_RS07715	COG0195	Participates in both transcription termination and antitermination
GM418_RS07720	COG0779	Required for maturation of 30S ribosomal subunits
GM418_RS07725	COG1078	dGTPase activity
GM418_RS07730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GM418_RS07735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GM418_RS07735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GM418_RS07740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GM418_RS07745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GM418_RS07750	COG0719	Fe-S assembly protein
GM418_RS07755	COG0396	ATPase activity
GM418_RS07760	COG0719	Fe-S assembly protein
GM418_RS07775	COG1592	Rubrerythrin
GM418_RS07780	COG2166	iron-sulfur cluster assembly
GM418_RS07785	COG2151	metal-sulfur cluster biosynthetic enzyme
GM418_RS07790	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS07795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GM418_RS07810	COG0626	cystathionine gamma-synthase activity
GM418_RS07830	COG0438	transferase activity, transferring glycosyl groups
GM418_RS07850	COG0318	PFAM AMP-dependent synthetase and ligase
GM418_RS07855	COG0528	UMP kinase activity
GM418_RS07860	COG0233	cytoplasmic translational termination
GM418_RS07875	COG0463	Glycosyl transferase, family 2
GM418_RS07885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS07895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GM418_RS07900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GM418_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS07915	COG0215	cysteine-tRNA ligase activity
GM418_RS07920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GM418_RS07930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GM418_RS08020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GM418_RS08025	COG0157	Belongs to the NadC ModD family
GM418_RS08030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GM418_RS08050	COG1253	flavin adenine dinucleotide binding
GM418_RS08055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM418_RS08070	COG3279	Response regulator of the LytR AlgR family
GM418_RS08075	COG2972	Histidine kinase
GM418_RS08095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GM418_RS08110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GM418_RS08120	COG0346	lactoylglutathione lyase activity
GM418_RS08125	COG1418	mRNA catabolic process
GM418_RS08140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GM418_RS08145	COG0284	orotidine-5'-phosphate decarboxylase activity
GM418_RS08160	COG3119	arylsulfatase activity
GM418_RS08165	COG3527	Alpha-acetolactate decarboxylase
GM418_RS08175	COG2207	Transcriptional regulator
GM418_RS08175	COG0662	Cupin 2, conserved barrel domain protein
GM418_RS08205	COG0673	inositol 2-dehydrogenase activity
GM418_RS08210	COG1629	transport
GM418_RS08210	COG4206	TonB-dependent receptor
GM418_RS08235	COG2234	aminopeptidase activity
GM418_RS08245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GM418_RS08265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GM418_RS08280	COG1774	PSP1 C-terminal conserved region
GM418_RS08285	COG0784	Response regulator, receiver
GM418_RS08290	COG3850	Histidine kinase
GM418_RS08290	COG3437	response regulator, receiver
GM418_RS08290	COG4999	Histidine kinase
GM418_RS08290	COG2205	protein histidine kinase activity
GM418_RS08300	COG0612	Peptidase, M16
GM418_RS08320	COG1629	transport
GM418_RS08320	COG4206	TonB-dependent receptor
GM418_RS08355	COG3940	Belongs to the glycosyl hydrolase 43 family
GM418_RS08360	COG3507	Belongs to the glycosyl hydrolase 43 family
GM418_RS08390	COG4206	TonB-dependent receptor
GM418_RS08390	COG1629	transport
GM418_RS08400	COG3119	arylsulfatase activity
GM418_RS08410	COG3119	arylsulfatase activity
GM418_RS08430	COG4206	TonB-dependent receptor
GM418_RS08430	COG1629	transport
GM418_RS08460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM418_RS08470	COG0494	nUDIX hydrolase
GM418_RS08530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GM418_RS08540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GM418_RS08565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GM418_RS08575	COG1454	alcohol dehydrogenase
GM418_RS08580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GM418_RS08605	COG0557	exoribonuclease II activity
GM418_RS08635	COG4771	TonB-dependent receptor
GM418_RS08680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GM418_RS08695	COG0667	Aldo Keto reductase
GM418_RS08705	COG1595	DNA-templated transcription, initiation
GM418_RS08725	COG0673	inositol 2-dehydrogenase activity
GM418_RS08735	COG0673	inositol 2-dehydrogenase activity
GM418_RS08745	COG3622	Belongs to the hyi family
GM418_RS08750	COG3250	beta-galactosidase activity
GM418_RS08755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS08780	COG5002	protein histidine kinase activity
GM418_RS08785	COG0745	RESPONSE REGULATOR receiver
GM418_RS08885	COG5002	protein histidine kinase activity
GM418_RS08890	COG0745	RESPONSE REGULATOR receiver
GM418_RS08905	COG0017	Asparaginyl-tRNA synthetase
GM418_RS08915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS08920	COG1040	competence protein
GM418_RS08945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GM418_RS08950	COG4221	oxidoreductase activity
GM418_RS08955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS08970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GM418_RS08980	COG0358	DNA primase activity
GM418_RS09010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GM418_RS09020	COG1215	transferase activity, transferring glycosyl groups
GM418_RS09030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GM418_RS09060	COG0778	Nitroreductase
GM418_RS09090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS09110	COG0515	serine threonine protein kinase
GM418_RS09110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS09130	COG4771	TonB-dependent receptor
GM418_RS09135	COG0864	Transcriptional regulator
GM418_RS09145	COG1940	carbohydrate kinase activity
GM418_RS09150	COG0738	Major facilitator superfamily
GM418_RS09155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GM418_RS09165	COG1121	(ABC) transporter
GM418_RS09170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GM418_RS09175	COG0363	glucosamine-6-phosphate deaminase activity
GM418_RS09185	COG1940	carbohydrate kinase activity
GM418_RS09205	COG1160	GTP binding
GM418_RS09210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GM418_RS09225	COG1136	(ABC) transporter
GM418_RS09230	COG1136	(ABC) transporter
GM418_RS09230	COG0577	efflux transmembrane transporter activity
GM418_RS09235	COG1136	(ABC) transporter
GM418_RS09235	COG0577	efflux transmembrane transporter activity
GM418_RS09260	COG4206	TonB-dependent receptor
GM418_RS09260	COG1629	transport
GM418_RS09270	COG3345	alpha-galactosidase
GM418_RS09275	COG3119	arylsulfatase activity
GM418_RS09290	COG3119	arylsulfatase activity
GM418_RS09300	COG0039	L-malate dehydrogenase activity
GM418_RS09320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GM418_RS09335	COG1136	(ABC) transporter
GM418_RS09360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GM418_RS09375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GM418_RS09400	COG2003	Belongs to the UPF0758 family
GM418_RS09405	COG0268	Binds directly to 16S ribosomal RNA
GM418_RS09415	COG1137	ATPase activity
GM418_RS09420	COG0805	protein transport
GM418_RS09425	COG0514	ATP-dependent DNA helicase (RecQ)
GM418_RS09445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GM418_RS09450	COG0537	adenosine 5'-monophosphoramidase activity
GM418_RS09460	COG3118	belongs to the thioredoxin family
GM418_RS09480	COG0606	chelatase, subunit chli
GM418_RS09505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GM418_RS09510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GM418_RS09515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM418_RS09525	COG0436	Aminotransferase
GM418_RS09535	COG0436	Aminotransferase
GM418_RS09540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GM418_RS09560	COG1228	amidohydrolase
GM418_RS09565	COG1228	amidohydrolase
GM418_RS09580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GM418_RS09585	COG0228	four-way junction DNA binding
GM418_RS09595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GM418_RS09615	COG0321	lipoyl(octanoyl) transferase activity
GM418_RS09620	COG0673	inositol 2-dehydrogenase activity
GM418_RS09635	COG0191	fructose-bisphosphate aldolase activity
GM418_RS09670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM418_RS09690	COG0438	transferase activity, transferring glycosyl groups
GM418_RS09705	COG1215	transferase activity, transferring glycosyl groups
GM418_RS09740	COG0656	L-ascorbic acid biosynthetic process
GM418_RS09745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GM418_RS09765	COG0579	oxidoreductase
GM418_RS09775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GM418_RS09785	COG2963	transposase activity
GM418_RS09790	COG1151	hydroxylamine reductase activity
GM418_RS09800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM418_RS09840	COG2192	nodulation
GM418_RS09845	COG1214	PFAM Peptidase M22, glycoprotease
GM418_RS09855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GM418_RS09870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GM418_RS09890	COG1428	Deoxynucleoside kinase
GM418_RS09895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GM418_RS09925	COG0561	phosphatase activity
GM418_RS09930	COG1629	transport
GM418_RS09930	COG4206	TonB-dependent receptor
GM418_RS09970	COG2755	lipolytic protein G-D-S-L family
GM418_RS09975	COG3507	Belongs to the glycosyl hydrolase 43 family
GM418_RS09980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GM418_RS10010	COG4206	TonB-dependent receptor
GM418_RS10035	COG1136	(ABC) transporter
GM418_RS10045	COG0717	Belongs to the dCTP deaminase family
GM418_RS10055	COG0523	cobalamin synthesis protein
GM418_RS10060	COG0523	cobalamin synthesis protein
GM418_RS10075	COG2207	Transcriptional regulator
GM418_RS10075	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS10140	COG3275	phosphorelay sensor kinase activity
GM418_RS10145	COG3275	phosphorelay sensor kinase activity
GM418_RS10155	COG3279	Response regulator of the LytR AlgR family
GM418_RS10180	COG2936	dipeptidyl-peptidase activity
GM418_RS10195	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS10195	COG1506	peptidase
GM418_RS10200	COG3157	Type VI secretion system effector, Hcp
GM418_RS10205	COG0006	proline dipeptidase activity
GM418_RS10215	COG1523	belongs to the glycosyl hydrolase 13 family
GM418_RS10225	COG0802	atpase or kinase
GM418_RS10230	COG0509	glycine decarboxylation via glycine cleavage system
GM418_RS10240	COG1519	Transferase
GM418_RS10275	COG1595	DNA-templated transcription, initiation
GM418_RS10285	COG4206	TonB-dependent receptor
GM418_RS10285	COG1629	transport
GM418_RS10305	COG3394	polysaccharide catabolic process
GM418_RS10350	COG0469	pyruvate kinase activity
GM418_RS10370	COG0673	inositol 2-dehydrogenase activity
GM418_RS10380	COG1012	belongs to the aldehyde dehydrogenase family
GM418_RS10385	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS10390	COG3962	Belongs to the TPP enzyme family
GM418_RS10410	COG1609	Transcriptional regulator
GM418_RS10415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS10435	COG1408	metallophosphoesterase
GM418_RS10445	COG1309	transcriptional regulator
GM418_RS10450	COG2133	pyrroloquinoline quinone binding
GM418_RS10500	COG1063	alcohol dehydrogenase
GM418_RS10520	COG4206	TonB-dependent receptor
GM418_RS10520	COG1629	transport
GM418_RS10525	COG0561	phosphatase activity
GM418_RS10540	COG4124	Belongs to the glycosyl hydrolase 26 family
GM418_RS10555	COG1629	transport
GM418_RS10555	COG4206	TonB-dependent receptor
GM418_RS10565	COG3119	arylsulfatase activity
GM418_RS10570	COG3119	arylsulfatase activity
GM418_RS10575	COG3119	arylsulfatase activity
GM418_RS10580	COG3119	arylsulfatase activity
GM418_RS10585	COG3119	arylsulfatase activity
GM418_RS10605	COG0784	Response regulator, receiver
GM418_RS10605	COG2205	protein histidine kinase activity
GM418_RS10630	COG5001	Diguanylate cyclase
GM418_RS10630	COG5002	protein histidine kinase activity
GM418_RS10630	COG3447	MASE1 domain protein
GM418_RS10635	COG2205	protein histidine kinase activity
GM418_RS10635	COG3437	response regulator, receiver
GM418_RS10635	COG4999	Histidine kinase
GM418_RS10635	COG3850	Histidine kinase
GM418_RS10640	COG0784	Response regulator, receiver
GM418_RS10640	COG2205	protein histidine kinase activity
GM418_RS10645	COG4946	Tricorn protease homolog
GM418_RS10645	COG0793	Belongs to the peptidase S41A family
GM418_RS10655	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS10670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GM418_RS10675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GM418_RS10680	COG0632	four-way junction helicase activity
GM418_RS10700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GM418_RS10700	COG0512	Glutamine amidotransferase of anthranilate synthase
GM418_RS10705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GM418_RS10710	COG0134	indole-3-glycerol-phosphate synthase activity
GM418_RS10715	COG0135	phosphoribosylanthranilate isomerase activity
GM418_RS10720	COG0133	tryptophan synthase activity
GM418_RS10725	COG0159	tryptophan synthase activity
GM418_RS10735	COG4206	TonB-dependent receptor
GM418_RS10735	COG1629	transport
GM418_RS10750	COG1629	transport
GM418_RS10750	COG4206	TonB-dependent receptor
GM418_RS10775	COG0673	inositol 2-dehydrogenase activity
GM418_RS10900	COG3728	DNA packaging
GM418_RS10900	COG5484	DNA packaging
GM418_RS11030	COG3177	Filamentation induced by cAMP protein fic
GM418_RS11065	COG1012	belongs to the aldehyde dehydrogenase family
GM418_RS11070	COG3250	beta-galactosidase activity
GM418_RS11080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GM418_RS11090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GM418_RS11095	COG2814	Major facilitator Superfamily
GM418_RS11100	COG4771	TonB-dependent receptor
GM418_RS11120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GM418_RS11125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GM418_RS11130	COG0113	porphobilinogen synthase activity
GM418_RS11140	COG0181	hydroxymethylbilane synthase activity
GM418_RS11145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GM418_RS11155	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GM418_RS11160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GM418_RS11165	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS11165	COG2207	Transcriptional regulator
GM418_RS11190	COG2226	methyltransferase
GM418_RS11225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS11235	COG0436	Aminotransferase
GM418_RS11270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GM418_RS11280	COG1595	DNA-templated transcription, initiation
GM418_RS11330	COG0756	dUTP diphosphatase activity
GM418_RS11335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GM418_RS11345	COG1959	2 iron, 2 sulfur cluster binding
GM418_RS11350	COG1139	Iron-sulfur cluster binding protein
GM418_RS11355	COG0698	ribose 5-phosphate isomerase
GM418_RS11370	COG2255	four-way junction helicase activity
GM418_RS11390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GM418_RS11395	COG0445	tRNA wobble uridine modification
GM418_RS11400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GM418_RS11405	COG0322	excinuclease ABC activity
GM418_RS11410	COG0482	sulfurtransferase activity
GM418_RS11415	COG1162	GTPase activity
GM418_RS11425	COG4591	ABC-type transport system involved in lipoprotein release permease component
GM418_RS11430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GM418_RS11440	COG3409	Peptidoglycan-binding domain 1 protein
GM418_RS11440	COG0793	Belongs to the peptidase S41A family
GM418_RS11480	COG1484	DNA-dependent DNA replication
GM418_RS11485	COG4584	PFAM Integrase catalytic
GM418_RS11490	COG1595	DNA-templated transcription, initiation
GM418_RS11500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS11535	COG3119	arylsulfatase activity
GM418_RS11540	COG3119	arylsulfatase activity
GM418_RS11570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS11585	COG1629	transport
GM418_RS11585	COG4206	TonB-dependent receptor
GM418_RS11590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GM418_RS11595	COG2186	Transcriptional regulator
GM418_RS11600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GM418_RS11615	COG4124	Belongs to the glycosyl hydrolase 26 family
GM418_RS11635	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GM418_RS11640	COG0300	oxidoreductase activity
GM418_RS11645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS11650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GM418_RS11655	COG0180	Tryptophanyl-tRNA synthetase
GM418_RS11660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GM418_RS11665	COG1609	Transcriptional regulator
GM418_RS11685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GM418_RS11700	COG4206	TonB-dependent receptor
GM418_RS11700	COG1629	transport
GM418_RS11715	COG3119	arylsulfatase activity
GM418_RS11725	COG3119	arylsulfatase activity
GM418_RS11730	COG3250	beta-galactosidase activity
GM418_RS11735	COG3119	arylsulfatase activity
GM418_RS11740	COG3119	arylsulfatase activity
GM418_RS11770	COG3119	arylsulfatase activity
GM418_RS11775	COG5002	protein histidine kinase activity
GM418_RS11780	COG3250	beta-galactosidase activity
GM418_RS11785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM418_RS11785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GM418_RS11790	COG1082	Xylose isomerase domain protein TIM barrel
GM418_RS11805	COG1490	D-aminoacyl-tRNA deacylase activity
GM418_RS11810	COG1694	Mazg nucleotide pyrophosphohydrolase
GM418_RS11830	COG0640	Transcriptional regulator
GM418_RS11845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GM418_RS11860	COG1355	regulation of microtubule-based process
GM418_RS11870	COG0784	Response regulator, receiver
GM418_RS11870	COG2205	protein histidine kinase activity
GM418_RS11880	COG2172	sigma factor antagonist activity
GM418_RS11885	COG1366	Belongs to the anti-sigma-factor antagonist family
GM418_RS11890	COG1366	Belongs to the anti-sigma-factor antagonist family
GM418_RS11915	COG2131	deaminase
GM418_RS11920	COG0793	Belongs to the peptidase S41A family
GM418_RS11930	COG2382	esterase
GM418_RS11955	COG1695	Transcriptional regulator
GM418_RS11975	COG0720	synthase
GM418_RS11980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GM418_RS11980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GM418_RS12005	COG0594	ribonuclease P activity
GM418_RS12010	COG1012	belongs to the aldehyde dehydrogenase family
GM418_RS12015	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GM418_RS12020	COG0287	Prephenate dehydrogenase
GM418_RS12035	COG1621	beta-fructofuranosidase activity
GM418_RS12080	COG4585	Histidine kinase
GM418_RS12085	COG2197	response regulator
GM418_RS12110	COG3275	phosphorelay sensor kinase activity
GM418_RS12115	COG3279	Response regulator of the LytR AlgR family
GM418_RS12120	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS12130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GM418_RS12155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GM418_RS12160	COG0019	diaminopimelate decarboxylase activity
GM418_RS12165	COG4413	Urea transporter
GM418_RS12190	COG0668	transmembrane transport
GM418_RS12215	COG1595	DNA-templated transcription, initiation
GM418_RS12225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GM418_RS12240	COG0731	radical SAM domain protein
GM418_RS12240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GM418_RS12255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GM418_RS12260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GM418_RS12260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GM418_RS12275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GM418_RS12310	COG1971	Probably functions as a manganese efflux pump
GM418_RS12335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GM418_RS12340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GM418_RS12345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GM418_RS12350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GM418_RS12355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GM418_RS12360	COG0356	it plays a direct role in the translocation of protons across the membrane
GM418_RS12405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GM418_RS12410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GM418_RS12420	COG3852	Histidine kinase
GM418_RS12425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GM418_RS12430	COG1360	Flagellar Motor Protein
GM418_RS12435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GM418_RS12440	COG0210	DNA helicase
GM418_RS12460	COG2094	Belongs to the DNA glycosylase MPG family
GM418_RS12495	COG1216	Glycosyl transferase, family 2
GM418_RS12525	COG0423	glycine-tRNA ligase activity
GM418_RS12550	COG0793	Belongs to the peptidase S41A family
GM418_RS12570	COG1309	transcriptional regulator
GM418_RS12595	COG2252	PERMEase
GM418_RS12645	COG1309	transcriptional regulator
GM418_RS12670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GM418_RS12675	COG0154	amidase activity
GM418_RS12685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GM418_RS12700	COG0778	Nitroreductase
GM418_RS12705	COG3360	Dodecin
GM418_RS12715	COG3119	arylsulfatase activity
GM418_RS12720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GM418_RS12730	COG1011	Hydrolase
GM418_RS12735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GM418_RS12740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GM418_RS12755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GM418_RS12765	COG3264	Mechanosensitive ion channel
GM418_RS12765	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GM418_RS12770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GM418_RS12770	COG3264	Mechanosensitive ion channel
GM418_RS12775	COG3613	nucleoside 2-deoxyribosyltransferase
GM418_RS12850	COG0446	pyridine nucleotide-disulphide oxidoreductase
GM418_RS12855	COG1501	Belongs to the glycosyl hydrolase 31 family
GM418_RS12860	COG0521	Mo-molybdopterin cofactor biosynthetic process
GM418_RS12865	COG0315	cyclic pyranopterin monophosphate synthase activity
GM418_RS12870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM418_RS12875	COG0303	'Molybdopterin
GM418_RS12900	COG1959	2 iron, 2 sulfur cluster binding
GM418_RS12940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GM418_RS12970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS12970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GM418_RS12975	COG2972	Histidine kinase
GM418_RS12980	COG3279	Response regulator of the LytR AlgR family
GM418_RS12985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GM418_RS12990	COG2045	Belongs to the ComB family
GM418_RS13010	COG1131	(ABC) transporter
GM418_RS13045	COG0826	peptidase U32
GM418_RS13065	COG0668	transmembrane transport
GM418_RS13070	COG1022	Amp-dependent synthetase and ligase
GM418_RS13080	COG2204	response regulator
GM418_RS13110	COG3275	phosphorelay sensor kinase activity
GM418_RS13115	COG3279	Response regulator of the LytR AlgR family
GM418_RS13120	COG0668	transmembrane transport
GM418_RS13135	COG2315	Protein conserved in bacteria
GM418_RS13145	COG1619	proteins homologs of microcin C7 resistance protein MccF
GM418_RS13185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GM418_RS13190	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GM418_RS13200	COG0437	4 iron, 4 sulfur cluster binding
GM418_RS13225	COG4206	TonB-dependent receptor
GM418_RS13225	COG1629	transport
GM418_RS13240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM418_RS13250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM418_RS13250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM418_RS13280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GM418_RS13305	COG0489	protein tyrosine kinase activity
GM418_RS13315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GM418_RS13325	COG1774	PSP1 C-terminal conserved region
GM418_RS13335	COG0470	DNA polymerase III
GM418_RS13340	COG0126	phosphoglycerate kinase activity
GM418_RS13355	COG3250	beta-galactosidase activity
GM418_RS13360	COG0156	8-amino-7-oxononanoate synthase activity
GM418_RS13365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GM418_RS13375	COG2814	Major facilitator Superfamily
GM418_RS13385	COG1136	(ABC) transporter
GM418_RS13385	COG0577	efflux transmembrane transporter activity
GM418_RS13395	COG1136	(ABC) transporter
GM418_RS13395	COG0577	efflux transmembrane transporter activity
GM418_RS13415	COG2972	Histidine kinase
GM418_RS13480	COG4206	TonB-dependent receptor
GM418_RS13480	COG1629	transport
GM418_RS13505	COG0006	proline dipeptidase activity
GM418_RS13515	COG1136	(ABC) transporter
GM418_RS13515	COG0577	efflux transmembrane transporter activity
GM418_RS13525	COG0577	efflux transmembrane transporter activity
GM418_RS13535	COG0577	efflux transmembrane transporter activity
GM418_RS13535	COG1136	(ABC) transporter
GM418_RS13605	COG0577	efflux transmembrane transporter activity
GM418_RS13605	COG1136	(ABC) transporter
GM418_RS13630	COG1136	(ABC) transporter
GM418_RS13630	COG0577	efflux transmembrane transporter activity
GM418_RS13640	COG0577	efflux transmembrane transporter activity
GM418_RS13655	COG1136	(ABC) transporter
GM418_RS13655	COG0577	efflux transmembrane transporter activity
GM418_RS13660	COG0577	efflux transmembrane transporter activity
GM418_RS13660	COG1136	(ABC) transporter
GM418_RS13665	COG0577	efflux transmembrane transporter activity
GM418_RS13725	COG1136	(ABC) transporter
GM418_RS13725	COG0577	efflux transmembrane transporter activity
GM418_RS13740	COG2204	response regulator
GM418_RS13745	COG3852	Histidine kinase
GM418_RS13755	COG1169	isochorismate synthase
GM418_RS13760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GM418_RS13765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GM418_RS13770	COG1575	Belongs to the MenA family. Type 1 subfamily
GM418_RS13805	COG0702	epimerase
GM418_RS13830	COG2972	Histidine kinase
GM418_RS13835	COG3279	Response regulator of the LytR AlgR family
GM418_RS13910	COG4584	PFAM Integrase catalytic
GM418_RS13910	COG2390	Transcriptional regulator
GM418_RS13915	COG1484	DNA-dependent DNA replication
GM418_RS13990	COG0438	transferase activity, transferring glycosyl groups
GM418_RS13995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GM418_RS14000	COG1595	DNA-templated transcription, initiation
GM418_RS14015	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS14025	COG0328	RNA-DNA hybrid ribonuclease activity
GM418_RS14030	COG3591	Belongs to the peptidase S1B family
GM418_RS14035	COG1266	CAAX protease self-immunity
GM418_RS14040	COG0739	heme binding
GM418_RS14045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GM418_RS14055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GM418_RS14065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GM418_RS14070	COG1410	methionine synthase
GM418_RS14070	COG0646	methionine synthase
GM418_RS14170	COG4206	TonB-dependent receptor
GM418_RS14170	COG1629	transport
GM418_RS14180	COG3291	Pkd domain containing protein
GM418_RS14180	COG4412	M6 family metalloprotease domain protein
GM418_RS14195	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GM418_RS14200	COG0784	Response regulator, receiver
GM418_RS14200	COG5002	protein histidine kinase activity
GM418_RS14205	COG4206	TonB-dependent receptor
GM418_RS14205	COG1629	transport
GM418_RS14215	COG3119	arylsulfatase activity
GM418_RS14220	COG3119	arylsulfatase activity
GM418_RS14230	COG3119	arylsulfatase activity
GM418_RS14235	COG3119	arylsulfatase activity
GM418_RS14245	COG3279	Response regulator of the LytR AlgR family
GM418_RS14295	COG1874	Beta-galactosidase
GM418_RS14320	COG4206	TonB-dependent receptor
GM418_RS14320	COG1629	transport
GM418_RS14325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GM418_RS14340	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS14340	COG1506	peptidase
GM418_RS14350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GM418_RS14355	COG0740	serine-type endopeptidase activity
GM418_RS14380	COG0583	DNA-binding transcription factor activity
GM418_RS14385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GM418_RS14395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GM418_RS14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS14415	COG2137	regulation of response to DNA damage stimulus
GM418_RS14450	COG1695	Transcriptional regulator
GM418_RS14460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GM418_RS14465	COG3153	acetyltransferase
GM418_RS14465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM418_RS14470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GM418_RS14500	COG4974	Belongs to the 'phage' integrase family
GM418_RS14505	COG4974	Belongs to the 'phage' integrase family
GM418_RS14595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GM418_RS14660	COG3604	Transcriptional regulator
GM418_RS14695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GM418_RS14705	COG1187	pseudouridine synthase activity
GM418_RS14710	COG1595	DNA-templated transcription, initiation
GM418_RS14725	COG1803	Methylglyoxal synthase
GM418_RS14735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GM418_RS14740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GM418_RS14755	COG0656	L-ascorbic acid biosynthetic process
GM418_RS14760	COG0527	aspartate kinase activity
GM418_RS14765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS14790	COG0525	valine-tRNA ligase activity
GM418_RS14795	COG3537	Alpha-1,2-mannosidase
GM418_RS14865	COG2610	gluconate transmembrane transporter activity
GM418_RS14870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GM418_RS14890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GM418_RS14895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GM418_RS14905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GM418_RS14915	COG4145	pantothenate transmembrane transporter activity
GM418_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS14930	COG0673	inositol 2-dehydrogenase activity
GM418_RS14935	COG3401	FG-GAP repeat protein
GM418_RS14955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GM418_RS14955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GM418_RS14960	COG0616	signal peptide processing
GM418_RS14975	COG3448	diguanylate cyclase activity
GM418_RS14975	COG4175	Glycine betaine
GM418_RS14985	COG1663	tetraacyldisaccharide 4'-kinase activity
GM418_RS14995	COG3386	PFAM SMP-30 Gluconolaconase
GM418_RS15025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GM418_RS15035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GM418_RS15035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GM418_RS15040	COG2890	protein-(glutamine-N5) methyltransferase activity
GM418_RS15050	COG0196	riboflavin kinase activity
GM418_RS15055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS15060	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GM418_RS15065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GM418_RS15085	COG2153	protein acetylation
GM418_RS15095	COG5012	cobalamin binding
GM418_RS15100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GM418_RS15100	COG0646	methionine synthase
GM418_RS15120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GM418_RS15145	COG1053	succinate dehydrogenase
GM418_RS15175	COG0434	BtpA family
GM418_RS15220	COG2205	protein histidine kinase activity
GM418_RS15250	COG0174	glutamine synthetase
GM418_RS15295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GM418_RS15300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS15345	COG0667	Aldo Keto reductase
GM418_RS15350	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS15355	COG1752	Esterase of the alpha-beta hydrolase superfamily
GM418_RS15360	COG0673	inositol 2-dehydrogenase activity
GM418_RS15365	COG0450	alkyl hydroperoxide reductase
GM418_RS15370	COG0673	inositol 2-dehydrogenase activity
GM418_RS15375	COG0450	alkyl hydroperoxide reductase
GM418_RS15380	COG1629	transport
GM418_RS15380	COG4206	TonB-dependent receptor
GM418_RS15420	COG1215	transferase activity, transferring glycosyl groups
GM418_RS15440	COG1629	transport
GM418_RS15440	COG4206	TonB-dependent receptor
GM418_RS15450	COG3119	arylsulfatase activity
GM418_RS15455	COG3119	arylsulfatase activity
GM418_RS15460	COG3250	beta-galactosidase activity
GM418_RS15470	COG1595	DNA-templated transcription, initiation
GM418_RS15480	COG1629	transport
GM418_RS15480	COG4206	TonB-dependent receptor
GM418_RS15490	COG3119	arylsulfatase activity
GM418_RS15500	COG1649	PFAM Uncharacterised BCR, COG1649
GM418_RS15510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GM418_RS15515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GM418_RS15545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GM418_RS15590	COG1629	transport
GM418_RS15590	COG4206	TonB-dependent receptor
GM418_RS15595	COG0463	Glycosyl transferase, family 2
GM418_RS15620	COG4206	TonB-dependent receptor
GM418_RS15620	COG1629	transport
GM418_RS15655	COG0673	inositol 2-dehydrogenase activity
GM418_RS15675	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GM418_RS15685	COG0347	Belongs to the P(II) protein family
GM418_RS15710	COG1433	Dinitrogenase iron-molybdenum cofactor
GM418_RS15710	COG0535	radical SAM domain protein
GM418_RS15725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GM418_RS15740	COG0725	ABC transporter, periplasmic molybdate-binding protein
GM418_RS15745	COG4149	molybdate abc transporter
GM418_RS15750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GM418_RS15790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GM418_RS15805	COG1501	Belongs to the glycosyl hydrolase 31 family
GM418_RS15810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GM418_RS15820	COG0561	phosphatase activity
GM418_RS15825	COG4206	TonB-dependent receptor
GM418_RS15825	COG1629	transport
GM418_RS15830	COG4591	ABC-type transport system involved in lipoprotein release permease component
GM418_RS15840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GM418_RS15845	COG2239	Acts as a magnesium transporter
GM418_RS15855	COG0189	ligase activity
GM418_RS15860	COG2988	succinylglutamate desuccinylase activity
GM418_RS15865	COG0577	efflux transmembrane transporter activity
GM418_RS15870	COG0138	bifunctional purine biosynthesis protein purh
GM418_RS15890	COG0768	penicillin binding
GM418_RS15895	COG0772	Belongs to the SEDS family
GM418_RS15910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GM418_RS15940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GM418_RS15945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GM418_RS15950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GM418_RS15955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GM418_RS15960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GM418_RS15970	COG0028	Belongs to the TPP enzyme family
GM418_RS15980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GM418_RS15995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GM418_RS16000	COG0671	phosphoesterase, PA-phosphatase related
GM418_RS16005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GM418_RS16010	COG0563	adenylate kinase activity
GM418_RS16020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GM418_RS16045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GM418_RS16045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GM418_RS16050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GM418_RS16085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM418_RS16095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GM418_RS16100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM418_RS16105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GM418_RS16105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GM418_RS16110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GM418_RS16125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GM418_RS16150	COG0357	Ribosomal RNA small subunit methyltransferase G
GM418_RS16155	COG0205	6-phosphofructokinase activity
GM418_RS16170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM418_RS16170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GM418_RS16175	COG1629	transport
GM418_RS16175	COG4206	TonB-dependent receptor
GM418_RS16190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GM418_RS16195	COG1435	thymidine kinase activity
GM418_RS16205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GM418_RS16215	COG1629	transport
GM418_RS16215	COG4206	TonB-dependent receptor
GM418_RS16240	COG0305	Participates in initiation and elongation during chromosome replication
GM418_RS16245	COG0564	pseudouridine synthase activity
GM418_RS16255	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GM418_RS16260	COG0730	response to heat
GM418_RS16295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS16315	COG0242	peptide deformylase activity
GM418_RS16330	COG1595	DNA-templated transcription, initiation
GM418_RS16380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GM418_RS16390	COG4251	negative regulation of phosphorylation
GM418_RS16405	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS16405	COG4977	sequence-specific DNA binding
GM418_RS16420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GM418_RS16465	COG3119	arylsulfatase activity
GM418_RS16475	COG0657	acetylesterase activity
GM418_RS16475	COG2755	lipolytic protein G-D-S-L family
GM418_RS16495	COG3119	arylsulfatase activity
GM418_RS16505	COG1629	transport
GM418_RS16505	COG4206	TonB-dependent receptor
GM418_RS16515	COG2197	response regulator
GM418_RS16550	COG3279	Response regulator of the LytR AlgR family
GM418_RS16590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GM418_RS16605	COG1428	Deoxynucleoside kinase
GM418_RS16615	COG1185	polyribonucleotide nucleotidyltransferase activity
GM418_RS16620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GM418_RS16635	COG0312	modulator of DNA gyrase
GM418_RS16640	COG0312	modulator of DNA gyrase
GM418_RS16645	COG0174	glutamine synthetase
GM418_RS16650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GM418_RS16655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GM418_RS16675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS16690	COG2885	chlorophyll binding
GM418_RS16705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GM418_RS16720	COG2235	arginine
GM418_RS16730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GM418_RS16735	COG2329	Antibiotic biosynthesis monooxygenase
GM418_RS16750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GM418_RS16760	COG0483	inositol monophosphate 1-phosphatase activity
GM418_RS16765	COG1063	alcohol dehydrogenase
GM418_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS16770	COG3347	Dehydrogenase
GM418_RS16790	COG2363	Small membrane protein
GM418_RS16800	COG0022	dehydrogenase e1 component
GM418_RS16820	COG0527	aspartate kinase activity
GM418_RS16825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GM418_RS16850	COG0517	IMP dehydrogenase activity
GM418_RS16850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GM418_RS16855	COG0045	succinate-CoA ligase (ADP-forming) activity
GM418_RS16860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GM418_RS16865	COG2198	Histidine kinase
GM418_RS16865	COG2205	protein histidine kinase activity
GM418_RS16865	COG0784	Response regulator, receiver
GM418_RS16870	COG2115	Belongs to the xylose isomerase family
GM418_RS16875	COG1070	Carbohydrate kinase
GM418_RS16880	COG1725	Transcriptional regulator
GM418_RS16890	COG0506	proline dehydrogenase activity
GM418_RS16920	COG2160	L-arabinose isomerase activity
GM418_RS16930	COG1254	Belongs to the acylphosphatase family
GM418_RS16945	COG1477	protein flavinylation
GM418_RS16950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GM418_RS16975	COG0673	inositol 2-dehydrogenase activity
GM418_RS16995	COG0598	Magnesium transport protein CorA
GM418_RS17015	COG5002	protein histidine kinase activity
GM418_RS17015	COG0784	Response regulator, receiver
GM418_RS17015	COG2198	Histidine kinase
GM418_RS17035	COG0471	metal ion transport
GM418_RS17065	COG3876	Protein conserved in bacteria
GM418_RS17070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS17085	COG0617	tRNA 3'-terminal CCA addition
GM418_RS17100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS17155	COG2226	methyltransferase
GM418_RS17155	COG1073	alpha beta
GM418_RS17160	COG0628	permease
GM418_RS17170	COG0437	4 iron, 4 sulfur cluster binding
GM418_RS17200	COG4152	abc transporter atp-binding protein
GM418_RS17205	COG1668	transmembrane transport
GM418_RS17220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GM418_RS17235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GM418_RS17240	COG0505	Belongs to the CarA family
GM418_RS17245	COG1438	arginine binding
GM418_RS17260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GM418_RS17265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GM418_RS17270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GM418_RS17275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GM418_RS17280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GM418_RS17290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GM418_RS17295	COG0107	imidazoleglycerol-phosphate synthase activity
GM418_RS17300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GM418_RS17300	COG0140	phosphoribosyl-ATP diphosphatase activity
GM418_RS17315	COG0004	ammonium transporteR
GM418_RS17320	COG0347	Belongs to the P(II) protein family
GM418_RS17340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GM418_RS17345	COG0165	Argininosuccinate lyase
GM418_RS17350	COG0069	glutamate synthase activity
GM418_RS17350	COG0070	glutamate synthase
GM418_RS17350	COG0067	glutamate synthase
GM418_RS17370	COG0584	glycerophosphoryl diester phosphodiesterase
GM418_RS17375	COG0339	signal peptide processing
GM418_RS17385	COG2226	methyltransferase
GM418_RS17400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GM418_RS17405	COG0194	GDP metabolic process
GM418_RS17410	COG1561	YicC-like family, N-terminal region
GM418_RS17415	COG0482	sulfurtransferase activity
GM418_RS17440	COG0513	Belongs to the DEAD box helicase family
GM418_RS17465	COG0784	Response regulator, receiver
GM418_RS17465	COG2205	protein histidine kinase activity
GM418_RS17470	COG2871	sodium ion transport
GM418_RS17475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GM418_RS17490	COG1805	sodium ion transport
GM418_RS17515	COG3437	response regulator, receiver
GM418_RS17515	COG2205	protein histidine kinase activity
GM418_RS17515	COG3850	Histidine kinase
GM418_RS17515	COG4999	Histidine kinase
GM418_RS17520	COG1012	belongs to the aldehyde dehydrogenase family
GM418_RS17530	COG1678	Uncharacterized ACR, COG1678
GM418_RS17550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GM418_RS17575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GM418_RS17580	COG0673	inositol 2-dehydrogenase activity
GM418_RS17585	COG0281	malic enzyme
GM418_RS17585	COG0280	phosphate acetyltransferase
GM418_RS17600	COG1629	transport
GM418_RS17600	COG4206	TonB-dependent receptor
GM418_RS17605	COG0561	phosphatase activity
GM418_RS17615	COG3119	arylsulfatase activity
GM418_RS17645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GM418_RS17645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GM418_RS17650	COG3119	arylsulfatase activity
GM418_RS17695	COG1595	DNA-templated transcription, initiation
GM418_RS17705	COG0012	GTP binding
GM418_RS17710	COG1862	Preprotein translocase
GM418_RS17720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GM418_RS17740	COG0415	Belongs to the DNA photolyase family
GM418_RS17750	COG0386	Belongs to the glutathione peroxidase family
GM418_RS17755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GM418_RS17775	COG0742	ribosomal rna small subunit methyltransferase
GM418_RS17795	COG1234	tRNA 3'-trailer cleavage
GM418_RS17825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GM418_RS17845	COG2267	carboxylic ester hydrolase activity
GM418_RS17850	COG0778	Nitroreductase
GM418_RS17865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GM418_RS17885	COG1104	cysteine desulfurase activity
GM418_RS17890	COG3033	Beta-eliminating lyase
GM418_RS17900	COG2197	response regulator
GM418_RS17905	COG1956	GAF domain-containing protein
GM418_RS17920	COG0124	histidyl-tRNA synthetase
GM418_RS17925	COG2986	histidine ammonia-lyase
GM418_RS17930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GM418_RS17950	COG1506	peptidase
GM418_RS17950	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS17955	COG3279	Response regulator of the LytR AlgR family
GM418_RS17960	COG3275	phosphorelay sensor kinase activity
GM418_RS17980	COG1640	4-alpha-glucanotransferase
GM418_RS17985	COG0596	Alpha beta hydrolase
GM418_RS17990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GM418_RS18000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GM418_RS18010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GM418_RS18055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GM418_RS18060	COG0674	pyruvate-flavodoxin oxidoreductase activity
GM418_RS18060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GM418_RS18065	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM418_RS18075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GM418_RS18085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GM418_RS18090	COG0167	dihydroorotate dehydrogenase activity
GM418_RS18135	COG1595	DNA-templated transcription, initiation
GM418_RS18145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GM418_RS18165	COG1609	Transcriptional regulator
GM418_RS18170	COG0673	inositol 2-dehydrogenase activity
GM418_RS18190	COG0363	glucosamine-6-phosphate deaminase activity
GM418_RS18220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GM418_RS18230	COG1271	oxidase subunit
GM418_RS18260	COG2264	protein methyltransferase activity
GM418_RS18300	COG0348	domain, Protein
GM418_RS18325	COG0149	triose-phosphate isomerase activity
GM418_RS18340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GM418_RS18345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GM418_RS18360	COG0463	Glycosyl transferase, family 2
GM418_RS18390	COG1695	Transcriptional regulator
GM418_RS18475	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GM418_RS18505	COG0072	phenylalanine-tRNA ligase activity
GM418_RS18505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GM418_RS18535	COG1595	DNA-templated transcription, initiation
GM418_RS18555	COG0668	transmembrane transport
GM418_RS18560	COG0339	signal peptide processing
GM418_RS18565	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS18590	COG4206	TonB-dependent receptor
GM418_RS18590	COG1629	transport
GM418_RS18605	COG1595	DNA-templated transcription, initiation
GM418_RS18625	COG1629	transport
GM418_RS18625	COG4206	TonB-dependent receptor
GM418_RS18665	COG0700	Nucleoside recognition
GM418_RS18680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GM418_RS18695	COG4206	TonB-dependent receptor
GM418_RS18695	COG1629	transport
GM418_RS18705	COG3537	Alpha-1,2-mannosidase
GM418_RS18725	COG3119	arylsulfatase activity
GM418_RS18730	COG3083	sulfuric ester hydrolase activity
GM418_RS18745	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS18750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS18765	COG0702	epimerase
GM418_RS18780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS18785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GM418_RS18825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM418_RS18835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GM418_RS18835	COG1648	precorrin-2 dehydrogenase activity
GM418_RS18840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GM418_RS18845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GM418_RS18850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS18900	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GM418_RS18945	COG2172	sigma factor antagonist activity
GM418_RS18970	COG2205	protein histidine kinase activity
GM418_RS18995	COG2258	MOSC domain
GM418_RS19000	COG0484	heat shock protein binding
GM418_RS19005	COG0237	dephospho-CoA kinase activity
GM418_RS19030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS19035	COG5002	protein histidine kinase activity
GM418_RS19065	COG0438	transferase activity, transferring glycosyl groups
GM418_RS19100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM418_RS19105	COG0745	RESPONSE REGULATOR receiver
GM418_RS19115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS19130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM418_RS19155	COG3321	synthase
GM418_RS19155	COG0604	alcohol dehydrogenase
GM418_RS19180	COG4753	response regulator
GM418_RS19180	COG2207	Transcriptional regulator
GM418_RS19195	COG0110	maltose O-acetyltransferase activity
GM418_RS19205	COG0778	Nitroreductase
GM418_RS19230	COG1629	transport
GM418_RS19230	COG4206	TonB-dependent receptor
GM418_RS19250	COG3275	phosphorelay sensor kinase activity
GM418_RS19255	COG3279	Response regulator of the LytR AlgR family
GM418_RS19265	COG2755	lipolytic protein G-D-S-L family
GM418_RS19270	COG0457	Tetratricopeptide repeat
GM418_RS19275	COG2814	Major facilitator Superfamily
GM418_RS19275	COG0477	Major facilitator Superfamily
GM418_RS19315	COG0596	Alpha beta hydrolase
GM418_RS19315	COG2945	thiolester hydrolase activity
GM418_RS19340	COG4584	PFAM Integrase catalytic
GM418_RS19345	COG1484	DNA-dependent DNA replication
GM418_RS19400	COG0537	adenosine 5'-monophosphoramidase activity
GM418_RS19535	COG2217	Heavy metal translocating P-type atpase
GM418_RS19540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GM418_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS19695	COG2217	Heavy metal translocating P-type atpase
GM418_RS19700	COG1830	Aldolase
GM418_RS19730	COG2132	Multicopper oxidase
GM418_RS19735	COG0531	amino acid
GM418_RS19755	COG2217	Heavy metal translocating P-type atpase
GM418_RS19805	COG0347	Belongs to the P(II) protein family
GM418_RS19810	COG1252	NADH dehydrogenase
GM418_RS19825	COG1994	Peptidase M50
GM418_RS19825	COG0517	IMP dehydrogenase activity
GM418_RS19845	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS19845	COG2169	Transcriptional regulator
GM418_RS19900	COG0543	2 iron, 2 sulfur cluster binding
GM418_RS19905	COG0493	'glutamate synthase
GM418_RS19925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GM418_RS19930	COG0626	cystathionine gamma-synthase activity
GM418_RS19960	COG1733	regulation of RNA biosynthetic process
GM418_RS19980	COG1309	transcriptional regulator
GM418_RS20015	COG0386	Belongs to the glutathione peroxidase family
GM418_RS20020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GM418_RS20025	COG0667	Aldo Keto reductase
GM418_RS20030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM418_RS20045	COG3384	dioxygenase
GM418_RS20055	COG0702	epimerase
GM418_RS20075	COG0730	response to heat
GM418_RS20080	COG0575	Belongs to the CDS family
GM418_RS20095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GM418_RS20240	COG3344	reverse transcriptase
GM418_RS20305	COG2003	Belongs to the UPF0758 family
GM418_RS20365	COG0432	Pfam Uncharacterised protein family UPF0047
GM418_RS20375	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GM418_RS20375	COG2885	chlorophyll binding
GM418_RS20440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GM418_RS20455	COG0424	maF-like protein
GM418_RS20460	COG4213	ABC transporter substrate-binding protein
GM418_RS20465	COG1073	alpha beta
GM418_RS20510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GM418_RS20515	COG0314	molybdopterin synthase activity
GM418_RS20525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GM418_RS20535	COG0746	molybdenum cofactor guanylyltransferase activity
GM418_RS20545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GM418_RS20555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GM418_RS20575	COG0179	Fumarylacetoacetate (FAA) hydrolase
GM418_RS20595	COG1115	amino acid carrier protein
GM418_RS20615	COG0745	RESPONSE REGULATOR receiver
GM418_RS20655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GM418_RS20660	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GM418_RS20700	COG0842	Transport permease protein
GM418_RS20705	COG0842	Transport permease protein
GM418_RS20710	COG1131	(ABC) transporter
GM418_RS20720	COG1131	(ABC) transporter
GM418_RS20725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS20780	COG4993	Dehydrogenase
GM418_RS20790	COG3590	peptidase
GM418_RS20805	COG1285	pathogenesis
GM418_RS20810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GM418_RS20815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GM418_RS20845	COG1242	4 iron, 4 sulfur cluster binding
GM418_RS20850	COG3537	Alpha-1,2-mannosidase
GM418_RS20855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GM418_RS20860	COG3279	Response regulator of the LytR AlgR family
GM418_RS20865	COG2972	Histidine kinase
GM418_RS20890	COG1032	radical SAM domain protein
GM418_RS20900	COG0488	(ABC) transporter
GM418_RS20905	COG4895	conserved protein (DUF2196)
GM418_RS20915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GM418_RS20970	COG2895	sulfate adenylyltransferase (ATP) activity
GM418_RS20975	COG0175	sulfate reduction
GM418_RS20980	COG3273	potassium ion transport
GM418_RS20980	COG0471	metal ion transport
GM418_RS21010	COG2226	methyltransferase
GM418_RS21020	COG2226	methyltransferase
GM418_RS21025	COG1595	DNA-templated transcription, initiation
GM418_RS21105	COG0433	COG0433 Predicted ATPase
GM418_RS21180	COG3279	Response regulator of the LytR AlgR family
GM418_RS21185	COG1032	radical SAM domain protein
GM418_RS21195	COG0330	HflC and HflK could
GM418_RS21225	COG0784	Response regulator, receiver
GM418_RS21225	COG2205	protein histidine kinase activity
GM418_RS21230	COG2198	Histidine kinase
GM418_RS21230	COG2205	protein histidine kinase activity
GM418_RS21230	COG0784	Response regulator, receiver
GM418_RS21230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM418_RS21260	COG0330	HflC and HflK could
GM418_RS21275	COG0598	Magnesium transport protein CorA
GM418_RS21305	COG0363	glucosamine-6-phosphate deaminase activity
GM418_RS21310	COG0438	transferase activity, transferring glycosyl groups
GM418_RS21315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GM418_RS21365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM418_RS21380	COG2207	Transcriptional regulator
GM418_RS21385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM418_RS21395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM418_RS21410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GM418_RS21415	COG0628	permease
GM418_RS21445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM418_RS21445	COG2205	protein histidine kinase activity
GM418_RS21470	COG0724	RNA recognition motif
GM418_RS21480	COG0513	Belongs to the DEAD box helicase family
GM418_RS21500	COG0587	DNA-directed DNA polymerase activity
GM418_RS21560	COG4206	TonB-dependent receptor
GM418_RS21560	COG1629	transport
GM418_RS21610	COG0561	phosphatase activity
GM418_RS21625	COG3119	arylsulfatase activity
GM418_RS21690	COG2197	response regulator
GM418_RS21720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GM418_RS21730	COG0318	PFAM AMP-dependent synthetase and ligase
GM418_RS21740	COG2188	Transcriptional regulator
GM418_RS21745	COG1085	galactose-1-phosphate uridylyltransferase
GM418_RS21765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GM418_RS21800	COG0511	ligase activity, forming carbon-carbon bonds
GM418_RS21805	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GM418_RS21820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GM418_RS21825	COG0549	Belongs to the carbamate kinase family
GM418_RS21830	COG1674	ftsk spoiiie
GM418_RS21835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GM418_RS21845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GM418_RS21850	COG4974	Belongs to the 'phage' integrase family
GM418_RS21860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS21895	COG3119	arylsulfatase activity
GM418_RS21900	COG3119	arylsulfatase activity
GM418_RS21910	COG1629	transport
GM418_RS21910	COG4206	TonB-dependent receptor
GM418_RS21930	COG1090	epimerase
GM418_RS21945	COG1446	asparaginase
GM418_RS21955	COG0724	RNA recognition motif
GM418_RS21965	COG0673	inositol 2-dehydrogenase activity
GM418_RS21980	COG1595	DNA-templated transcription, initiation
GM418_RS22005	COG1331	Highly conserved protein containing a thioredoxin domain
GM418_RS22020	COG1505	serine-type exopeptidase activity
GM418_RS22050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GM418_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS22110	COG0738	Major facilitator superfamily
GM418_RS22135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GM418_RS22145	COG0367	asparagine synthase
GM418_RS22150	COG0519	Catalyzes the synthesis of GMP from XMP
GM418_RS22150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GM418_RS22155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS22180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GM418_RS22200	COG1705	Flagellar rod assembly protein muramidase FlgJ
GM418_RS22205	COG0295	cytidine deaminase activity
GM418_RS22210	COG0564	pseudouridine synthase activity
GM418_RS22215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GM418_RS22235	COG0443	Heat shock 70 kDa protein
GM418_RS22245	COG4974	Belongs to the 'phage' integrase family
GM418_RS22310	COG5297	Belongs to the glycosyl hydrolase family 6
GM418_RS22310	COG4733	cellulase activity
GM418_RS22340	COG1328	CTP reductase activity
GM418_RS22340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GM418_RS22350	COG2197	response regulator
GM418_RS22365	COG0583	DNA-binding transcription factor activity
GM418_RS22370	COG0783	Belongs to the Dps family
GM418_RS22395	COG1570	exodeoxyribonuclease VII activity
GM418_RS22400	COG1722	exodeoxyribonuclease VII activity
GM418_RS22425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM418_RS22450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM418_RS22455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GM418_RS22480	COG0673	inositol 2-dehydrogenase activity
GM418_RS22490	COG3387	PFAM Glycoside hydrolase 15-related
GM418_RS22510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GM418_RS22525	COG1027	Aspartate ammonia-lyase
GM418_RS22545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GM418_RS22550	COG0659	secondary active sulfate transmembrane transporter activity
GM418_RS22575	COG3142	Participates in the control of copper homeostasis
GM418_RS22580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GM418_RS22590	COG3610	response to peptide
GM418_RS22600	COG0024	Methionine aminopeptidase
GM418_RS22620	COG1629	transport
GM418_RS22620	COG4206	TonB-dependent receptor
GM418_RS22680	COG0101	tRNA pseudouridine synthase activity
GM418_RS22685	COG4864	UPF0365 protein
GM418_RS22710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GM418_RS22720	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GM418_RS22725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GM418_RS22730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM418_RS22735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GM418_RS22740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GM418_RS22740	COG1918	ferrous iron import across plasma membrane
GM418_RS22800	COG2003	Belongs to the UPF0758 family
GM418_RS22815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GM418_RS22975	COG1309	transcriptional regulator
GM418_RS23005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GM418_RS23010	COG1309	transcriptional regulator
GM418_RS23025	COG1309	transcriptional regulator
GM418_RS23035	COG4206	TonB-dependent receptor
GM418_RS23035	COG1629	transport
GM418_RS23040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GM418_RS23055	COG0575	Belongs to the CDS family
GM418_RS23095	COG1309	transcriptional regulator
GM418_RS23105	COG2207	Transcriptional regulator
GM418_RS23115	COG0463	Glycosyl transferase, family 2
GM418_RS23160	COG3279	Response regulator of the LytR AlgR family
GM418_RS23165	COG2972	Histidine kinase
GM418_RS23195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GM418_RS23215	COG3279	Response regulator of the LytR AlgR family
GM418_RS23225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GM418_RS23230	COG1136	(ABC) transporter
GM418_RS23230	COG0577	efflux transmembrane transporter activity
GM418_RS23235	COG1136	(ABC) transporter
GM418_RS23255	COG0656	L-ascorbic acid biosynthetic process
GM418_RS23290	COG0513	Belongs to the DEAD box helicase family
GM418_RS23300	COG0724	RNA recognition motif
GM418_RS23325	COG1278	Cold shock
GM418_RS23330	COG0438	transferase activity, transferring glycosyl groups
GM418_RS23335	COG0784	Response regulator, receiver
GM418_RS23335	COG2205	protein histidine kinase activity
GM418_RS23365	COG1032	radical SAM domain protein
GM418_RS23370	COG3279	Response regulator of the LytR AlgR family
GM418_RS23395	COG0546	phosphoglycolate phosphatase activity
GM418_RS23405	COG3119	arylsulfatase activity
GM418_RS23410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GM418_RS23415	COG2814	Major facilitator Superfamily
GM418_RS23420	COG3119	arylsulfatase activity
GM418_RS23440	COG2207	Transcriptional regulator
GM418_RS23455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM418_RS23480	COG0402	S-adenosylhomocysteine deaminase activity
GM418_RS23485	COG4412	M6 family metalloprotease domain protein
GM418_RS23485	COG3291	Pkd domain containing protein
GM418_RS23510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM418_RS23520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GM418_RS23540	COG1609	Transcriptional regulator
GM418_RS23550	COG1063	alcohol dehydrogenase
GM418_RS23570	COG1902	pentaerythritol trinitrate reductase activity
GM418_RS23610	COG2226	methyltransferase
GM418_RS23655	COG0730	response to heat
GM418_RS23660	COG0575	Belongs to the CDS family
GM418_RS23675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GM418_RS23680	COG4206	TonB-dependent receptor
GM418_RS23680	COG1629	transport
GM418_RS23720	COG0471	metal ion transport
GM418_RS23720	COG3273	potassium ion transport
GM418_RS23745	COG0175	sulfate reduction
GM418_RS23750	COG2895	sulfate adenylyltransferase (ATP) activity
GM418_RS23770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GM418_RS23790	COG0529	Catalyzes the synthesis of activated sulfate
GM418_RS23810	COG1216	Glycosyl transferase, family 2
GM418_RS23815	COG1216	Glycosyl transferase, family 2
GM418_RS23835	COG0134	indole-3-glycerol-phosphate synthase activity
GM418_RS23845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS23865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS23910	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GM418_RS23915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM418_RS23955	COG1730	sister chromatid segregation
GM418_RS23970	COG0784	Response regulator, receiver
GM418_RS23970	COG2198	Histidine kinase
GM418_RS23970	COG2205	protein histidine kinase activity
GM418_RS23970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM418_RS23975	COG1333	cytochrome c biogenesis protein
GM418_RS23975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GM418_RS23985	COG3005	denitrification pathway
GM418_RS24020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GM418_RS24035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GM418_RS24040	COG0788	formyltetrahydrofolate deformylase activity
GM418_RS24045	COG0131	Imidazoleglycerol-phosphate dehydratase
GM418_RS24050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GM418_RS24055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GM418_RS24060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GM418_RS24075	COG1051	belongs to the nudix hydrolase family
GM418_RS24080	COG0626	cystathionine gamma-synthase activity
GM418_RS24085	COG1757	Na H antiporter
GM418_RS24105	COG0629	single-stranded DNA binding
GM418_RS24125	COG1136	(ABC) transporter
GM418_RS24130	COG1136	(ABC) transporter
GM418_RS24130	COG0577	efflux transmembrane transporter activity
GM418_RS24135	COG0577	efflux transmembrane transporter activity
GM418_RS24145	COG1309	transcriptional regulator
GM418_RS24150	COG0673	inositol 2-dehydrogenase activity
GM418_RS24170	COG2972	Histidine kinase
GM418_RS24180	COG5505	Protein of unknown function (DUF819)
GM418_RS24195	COG0442	prolyl-tRNA aminoacylation
GM418_RS24205	COG2195	Cleaves the N-terminal amino acid of tripeptides
GM418_RS24210	COG0037	tRNA processing
GM418_RS24225	COG0457	Tetratricopeptide repeat
GM418_RS24230	COG3250	beta-galactosidase activity
GM418_RS24235	COG2205	protein histidine kinase activity
GM418_RS24235	COG0784	Response regulator, receiver
GM418_RS24255	COG1629	transport
GM418_RS24255	COG4206	TonB-dependent receptor
GM418_RS24270	COG1136	(ABC) transporter
GM418_RS24270	COG0577	efflux transmembrane transporter activity
GM418_RS24285	COG0708	Exodeoxyribonuclease III
GM418_RS24295	COG3119	arylsulfatase activity
GM418_RS24300	COG1278	Cold shock
GM418_RS24310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM418_RS24315	COG2957	Belongs to the agmatine deiminase family
GM418_RS24330	COG4206	TonB-dependent receptor
GM418_RS24330	COG1629	transport
GM418_RS24375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GM418_RS24385	COG3250	beta-galactosidase activity
GM418_RS24405	COG2996	Protein conserved in bacteria
GM418_RS24410	COG3534	alpha-L-arabinofuranosidase
GM418_RS24435	COG2234	aminopeptidase activity
GM418_RS24435	COG4935	Belongs to the peptidase S8 family
GM418_RS24445	COG0745	RESPONSE REGULATOR receiver
GM418_RS24450	COG5002	protein histidine kinase activity
GM418_RS24465	COG1660	Displays ATPase and GTPase activities
GM418_RS24475	COG0217	transcriptional regulatory protein
GM418_RS24485	COG3119	arylsulfatase activity
GM418_RS24495	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS24530	COG3549	Plasmid maintenance system killer
GM418_RS24545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GM418_RS24565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS24585	COG2154	pterin-4-alpha-carbinolamine dehydratase
GM418_RS24625	COG2304	oxidoreductase activity
GM418_RS24635	COG2814	Major facilitator Superfamily
GM418_RS24640	COG0702	epimerase
GM418_RS24645	COG1506	peptidase
GM418_RS24645	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS24655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GM418_RS24665	COG3409	Peptidoglycan-binding domain 1 protein
GM418_RS24665	COG5632	N-Acetylmuramoyl-L-alanine amidase
GM418_RS24715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GM418_RS24715	COG0116	Belongs to the methyltransferase superfamily
GM418_RS24720	COG1045	serine acetyltransferase
GM418_RS24735	COG0793	Belongs to the peptidase S41A family
GM418_RS24740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GM418_RS24740	COG0519	Catalyzes the synthesis of GMP from XMP
GM418_RS24745	COG3942	CHAP domain
GM418_RS24745	COG1388	LysM domain
GM418_RS24750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GM418_RS24765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GM418_RS24775	COG1446	asparaginase
GM418_RS24785	COG1119	ATPase activity
GM418_RS24805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS24845	COG0681	Belongs to the peptidase S26 family
GM418_RS24850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GM418_RS24860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GM418_RS24870	COG3119	arylsulfatase activity
GM418_RS24880	COG0384	phenazine biosynthesis protein PhzF
GM418_RS24920	COG3119	arylsulfatase activity
GM418_RS24935	COG4206	TonB-dependent receptor
GM418_RS24935	COG1629	transport
GM418_RS24945	COG0784	Response regulator, receiver
GM418_RS24945	COG2205	protein histidine kinase activity
GM418_RS24955	COG4771	TonB-dependent receptor
GM418_RS24960	COG4206	TonB-dependent receptor
GM418_RS24970	COG2204	response regulator
GM418_RS24980	COG1940	carbohydrate kinase activity
GM418_RS24990	COG1063	alcohol dehydrogenase
GM418_RS24995	COG1454	alcohol dehydrogenase
GM418_RS25000	COG4206	TonB-dependent receptor
GM418_RS25000	COG1629	transport
GM418_RS25020	COG3119	arylsulfatase activity
GM418_RS25025	COG3119	arylsulfatase activity
GM418_RS25045	COG3119	arylsulfatase activity
GM418_RS25060	COG1760	l-serine dehydratase
GM418_RS25065	COG3537	Alpha-1,2-mannosidase
GM418_RS25070	COG3250	beta-galactosidase activity
GM418_RS25100	COG3537	Alpha-1,2-mannosidase
GM418_RS25145	COG1979	alcohol dehydrogenase
GM418_RS25175	COG0791	NLP P60 protein
GM418_RS25180	COG1056	cytidyltransferase-related domain
GM418_RS25180	COG1051	belongs to the nudix hydrolase family
GM418_RS25205	COG0501	Belongs to the peptidase M48B family
GM418_RS25210	COG1546	Belongs to the CinA family
GM418_RS25210	COG1058	Belongs to the CinA family
GM418_RS25235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GM418_RS25285	COG1181	Belongs to the D-alanine--D-alanine ligase family
GM418_RS25290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GM418_RS25300	COG1289	transmembrane transporter activity
GM418_RS25345	COG1280	lysine exporter protein (LysE YggA)
GM418_RS25350	COG0488	(ABC) transporter
GM418_RS25355	COG5002	protein histidine kinase activity
GM418_RS25355	COG3850	Histidine kinase
GM418_RS25360	COG0745	RESPONSE REGULATOR receiver
GM418_RS25365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GM418_RS25365	COG2205	protein histidine kinase activity
GM418_RS25425	COG1943	Transposase
GM418_RS25455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GM418_RS25495	COG3119	arylsulfatase activity
GM418_RS25530	COG0489	protein tyrosine kinase activity
GM418_RS25565	COG4584	PFAM Integrase catalytic
GM418_RS25570	COG1484	DNA-dependent DNA replication
GM418_RS25610	COG4974	Belongs to the 'phage' integrase family
GM418_RS25620	COG1473	amidohydrolase
GM418_RS25635	COG2197	response regulator
GM418_RS25640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GM418_RS25660	COG1506	peptidase
GM418_RS25660	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS25665	COG4412	M6 family metalloprotease domain protein
GM418_RS25665	COG3291	Pkd domain containing protein
GM418_RS25685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GM418_RS25690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GM418_RS25695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GM418_RS25700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GM418_RS25715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GM418_RS25735	COG0105	UTP biosynthetic process
GM418_RS25740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GM418_RS25775	COG4372	Transposase
GM418_RS25785	COG4974	Belongs to the 'phage' integrase family
GM418_RS25805	COG3119	arylsulfatase activity
GM418_RS25810	COG3119	arylsulfatase activity
GM418_RS25815	COG0673	inositol 2-dehydrogenase activity
GM418_RS25825	COG3119	arylsulfatase activity
GM418_RS25835	COG4206	TonB-dependent receptor
GM418_RS25835	COG1629	transport
GM418_RS25870	COG1629	transport
GM418_RS25870	COG4206	TonB-dependent receptor
GM418_RS25880	COG1053	succinate dehydrogenase
GM418_RS25895	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS25905	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS25915	COG1063	alcohol dehydrogenase
GM418_RS25925	COG1070	Carbohydrate kinase
GM418_RS25930	COG3119	arylsulfatase activity
GM418_RS25940	COG1136	(ABC) transporter
GM418_RS25970	COG0698	ribose 5-phosphate isomerase
GM418_RS25975	COG2207	Transcriptional regulator
GM418_RS25980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GM418_RS26100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS26105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GM418_RS26155	COG1629	transport
GM418_RS26155	COG4206	TonB-dependent receptor
GM418_RS26165	COG4409	exo-alpha-(2->6)-sialidase activity
GM418_RS26180	COG1940	carbohydrate kinase activity
GM418_RS26185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GM418_RS26195	COG3537	Alpha-1,2-mannosidase
GM418_RS26200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GM418_RS26200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GM418_RS26240	COG2942	2-epimerase
GM418_RS26250	COG0793	Belongs to the peptidase S41A family
GM418_RS26250	COG4946	Tricorn protease homolog
GM418_RS26265	COG0148	phosphopyruvate hydratase activity
GM418_RS26275	COG1993	acr, cog1993
GM418_RS26280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GM418_RS26285	COG2027	D-alanyl-D-alanine carboxypeptidase
GM418_RS26380	COG1222	aaa ATPase
GM418_RS26395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GM418_RS26405	COG1136	(ABC) transporter
GM418_RS26410	COG2096	Adenosyltransferase
GM418_RS26425	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS26435	COG1472	Belongs to the glycosyl hydrolase 3 family
GM418_RS26440	COG1404	Belongs to the peptidase S8 family
GM418_RS26475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GM418_RS26490	COG0667	Aldo Keto reductase
GM418_RS26510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GM418_RS26525	COG3459	Glycosyltransferase 36 associated
GM418_RS26545	COG2382	esterase
GM418_RS26550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GM418_RS26550	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GM418_RS26555	COG4251	negative regulation of phosphorylation
GM418_RS26565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM418_RS26610	COG1408	metallophosphoesterase
GM418_RS26620	COG0543	2 iron, 2 sulfur cluster binding
GM418_RS26625	COG0167	dihydroorotate dehydrogenase activity
GM418_RS26630	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM418_RS26635	COG0022	dehydrogenase e1 component
GM418_RS26650	COG0504	CTP synthase activity
GM418_RS26655	COG0706	membrane insertase activity
GM418_RS26675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GM418_RS26690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GM418_RS26690	COG2885	chlorophyll binding
GM418_RS26710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GM418_RS26720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GM418_RS26730	COG0516	GMP reductase activity
GM418_RS26730	COG0517	IMP dehydrogenase activity
GM418_RS26740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GM418_RS26770	COG0653	protein targeting
GM418_RS26775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GM418_RS26780	COG4771	TonB-dependent receptor
GM418_RS26805	COG1047	Peptidyl-prolyl cis-trans
GM418_RS26810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GM418_RS26850	COG1760	l-serine dehydratase
GM418_RS26875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS26900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GM418_RS26910	COG0006	proline dipeptidase activity
GM418_RS26925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GM418_RS26930	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS26940	COG0564	pseudouridine synthase activity
GM418_RS26945	COG0823	Involved in the tonB-independent uptake of proteins
GM418_RS26945	COG1506	peptidase
GM418_RS26950	COG1278	Cold shock
GM418_RS26960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GM418_RS26970	COG0612	Peptidase, M16
GM418_RS26980	COG3118	belongs to the thioredoxin family
GM418_RS26995	COG4206	TonB-dependent receptor
GM418_RS26995	COG1629	transport
GM418_RS27015	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS27025	COG2226	methyltransferase
GM418_RS27030	COG4771	TonB-dependent receptor
GM418_RS27045	COG4206	TonB-dependent receptor
GM418_RS27045	COG1629	transport
GM418_RS27075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM418_RS27110	COG0673	inositol 2-dehydrogenase activity
GM418_RS27120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GM418_RS27165	COG1629	transport
GM418_RS27165	COG4206	TonB-dependent receptor
GM418_RS27180	COG0673	inositol 2-dehydrogenase activity
GM418_RS27205	COG3119	arylsulfatase activity
GM418_RS27230	COG3291	Pkd domain containing protein
GM418_RS27230	COG4412	M6 family metalloprotease domain protein
GM418_RS27245	COG3119	arylsulfatase activity
GM418_RS27270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GM418_RS27290	COG0738	Major facilitator superfamily
GM418_RS27345	COG0492	ferredoxin-NADP+ reductase activity
GM418_RS27355	COG0156	8-amino-7-oxononanoate synthase activity
GM418_RS27380	COG0497	DNA recombination
GM418_RS27385	COG3119	arylsulfatase activity
GM418_RS27410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GM418_RS27415	COG0542	response to heat
GM418_RS27440	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS27445	COG0308	aminopeptidase N
GM418_RS27450	COG1070	Carbohydrate kinase
GM418_RS27455	COG4771	TonB-dependent receptor
GM418_RS27460	COG2208	phosphoserine phosphatase activity
GM418_RS27475	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS27480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GM418_RS27485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GM418_RS27490	COG4974	Belongs to the 'phage' integrase family
GM418_RS27530	COG1136	(ABC) transporter
GM418_RS27530	COG0577	efflux transmembrane transporter activity
GM418_RS27550	COG0776	regulation of translation
GM418_RS27595	COG0095	Lipoate-protein ligase
GM418_RS27680	COG1629	transport
GM418_RS27680	COG4206	TonB-dependent receptor
GM418_RS27690	COG0584	glycerophosphoryl diester phosphodiesterase
GM418_RS27700	COG1629	transport
GM418_RS27700	COG4206	TonB-dependent receptor
GM418_RS27720	COG3279	Response regulator of the LytR AlgR family
GM418_RS27730	COG3275	phosphorelay sensor kinase activity
GM418_RS27750	COG0175	sulfate reduction
GM418_RS27755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GM418_RS27770	COG0514	ATP-dependent DNA helicase (RecQ)
GM418_RS27775	COG0517	IMP dehydrogenase activity
GM418_RS27775	COG0516	GMP reductase activity
GM418_RS27780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM418_RS27790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GM418_RS27795	COG0714	Associated with various cellular activities
GM418_RS27805	COG0277	FAD linked oxidase domain protein
GM418_RS27810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GM418_RS27815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GM418_RS27820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GM418_RS27830	COG0066	3-isopropylmalate dehydratase activity
GM418_RS27835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GM418_RS27840	COG0473	3-isopropylmalate dehydrogenase activity
GM418_RS27855	COG3279	Response regulator of the LytR AlgR family
GM418_RS27860	COG3275	phosphorelay sensor kinase activity
GM418_RS27870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GM418_RS27895	COG4452	Inner membrane protein CreD
GM418_RS27910	COG2205	protein histidine kinase activity
GM418_RS27910	COG0784	Response regulator, receiver
GM418_RS27910	COG5002	protein histidine kinase activity
GM418_RS27925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GM418_RS27940	COG0724	RNA recognition motif
GM418_RS27955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GM418_RS27960	COG0084	hydrolase, TatD family'
GM418_RS27965	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GM418_RS27970	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GM418_RS27980	COG0460	homoserine dehydrogenase
GM418_RS27980	COG0527	aspartate kinase activity
GM418_RS27985	COG3279	Response regulator of the LytR AlgR family
GM418_RS28000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GM418_RS28015	COG1629	transport
GM418_RS28015	COG4206	TonB-dependent receptor
GM418_RS28050	COG3119	arylsulfatase activity
GM418_RS28070	COG2885	chlorophyll binding
GM418_RS28125	COG3537	Alpha-1,2-mannosidase
GM418_RS28130	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GM418_RS28135	COG1518	maintenance of DNA repeat elements
GM418_RS28155	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
GM418_RS28165	COG2814	Major facilitator Superfamily
GM418_RS28170	COG0427	acetyl-CoA hydrolase
GM418_RS28175	COG0346	lactoylglutathione lyase activity
GM418_RS28180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GM418_RS28190	COG0511	ligase activity, forming carbon-carbon bonds
GM418_RS28195	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GM418_RS28215	COG3119	arylsulfatase activity
GM418_RS28235	COG1477	protein flavinylation
GM418_RS28240	COG3458	cephalosporin-C deacetylase activity
GM418_RS28265	COG3250	beta-galactosidase activity
GM418_RS28300	COG1629	transport
GM418_RS28300	COG4206	TonB-dependent receptor
GM418_RS28340	COG0006	proline dipeptidase activity
GM418_RS28365	COG4221	oxidoreductase activity
GM418_RS28375	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM418_RS28400	COG0716	FMN binding
GM418_RS28405	COG0077	Prephenate dehydratase
GM418_RS28405	COG1605	Chorismate mutase
GM418_RS28415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GM418_RS28440	COG2226	methyltransferase
GM418_RS28505	COG4717	serine-type aminopeptidase activity
GM418_RS28525	COG2610	gluconate transmembrane transporter activity
GM418_RS28540	COG5002	protein histidine kinase activity
GM418_RS28545	COG0114	fumarate hydratase activity
GM418_RS28565	COG1476	TRANSCRIPTIONal
GM418_RS28600	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM418_RS28615	COG0488	(ABC) transporter
GM418_RS28625	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GM418_RS28630	COG1518	maintenance of DNA repeat elements
GM418_RS28680	COG0464	growth
GM418_RS28705	COG4372	Transposase
GM418_RS28720	COG3119	arylsulfatase activity
GM418_RS28725	COG3250	beta-galactosidase activity
GM418_RS28730	COG3119	arylsulfatase activity
GM418_RS28740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS28780	COG3507	Belongs to the glycosyl hydrolase 43 family
GM418_RS28800	COG3119	arylsulfatase activity
GM418_RS28805	COG1966	Carbon starvation protein
GM418_RS28810	COG2273	Hydrolase Family 16
GM418_RS28810	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GM418_RS28825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS28855	COG1629	transport
GM418_RS28855	COG4206	TonB-dependent receptor
GM418_RS28860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GM418_RS28865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GM418_RS28890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GM418_RS28905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GM418_RS28925	COG1629	transport
GM418_RS28925	COG4206	TonB-dependent receptor
GM418_RS28945	COG1373	ATPase (AAA superfamily
GM418_RS28955	COG3507	Belongs to the glycosyl hydrolase 43 family
GM418_RS28985	COG3119	arylsulfatase activity
GM418_RS29015	COG3250	beta-galactosidase activity
GM418_RS29020	COG3119	arylsulfatase activity
GM418_RS29065	COG3250	beta-galactosidase activity
GM418_RS29070	COG3250	beta-galactosidase activity
GM418_RS29095	COG4206	TonB-dependent receptor
GM418_RS29095	COG1629	transport
GM418_RS29130	COG1484	DNA-dependent DNA replication
GM418_RS29135	COG4584	PFAM Integrase catalytic
GM418_RS29160	COG0588	phosphoglycerate mutase activity
GM418_RS29165	COG1830	Aldolase
GM418_RS29175	COG2226	methyltransferase
GM418_RS29180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GM418_RS29180	COG1918	ferrous iron import across plasma membrane
GM418_RS29185	COG2226	methyltransferase
GM418_RS29200	COG1132	(ABC) transporter
GM418_RS29205	COG1132	(ABC) transporter
GM418_RS29230	COG1429	ligase activity, forming nitrogen-metal bonds
GM418_RS29240	COG4771	TonB-dependent receptor
GM418_RS29250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GM418_RS29255	COG0716	FMN binding
GM418_RS29265	COG4206	TonB-dependent receptor
GM418_RS29270	COG2197	response regulator
GM418_RS29295	COG3335	DDE superfamily endonuclease
GM418_RS29315	COG2205	protein histidine kinase activity
GM418_RS29315	COG0784	Response regulator, receiver
GM418_RS29325	COG4584	PFAM Integrase catalytic
GM418_RS29330	COG1484	DNA-dependent DNA replication
GM418_RS29335	COG5002	protein histidine kinase activity
GM418_RS29345	COG0776	regulation of translation
GM418_RS29355	COG1484	DNA-dependent DNA replication
GM418_RS29365	COG2205	protein histidine kinase activity
GM418_RS29375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GM418_RS29405	COG0783	Belongs to the Dps family
GM418_RS29410	COG0450	alkyl hydroperoxide reductase
GM418_RS29420	COG0242	peptide deformylase activity
GM418_RS29430	COG0731	radical SAM domain protein
GM418_RS29435	COG0489	protein tyrosine kinase activity
GM418_RS29525	COG3335	DDE superfamily endonuclease
GM418_RS29540	COG5002	protein histidine kinase activity
GM418_RS29540	COG0784	Response regulator, receiver
GM418_RS29540	COG2198	Histidine kinase
GM418_RS29570	COG3237	CsbD-like
GM418_RS29585	COG0628	permease
GM418_RS29650	COG0776	regulation of translation
GM418_RS29675	COG2204	response regulator
GM418_RS29690	COG4977	sequence-specific DNA binding
GM418_RS29690	COG1917	Cupin 2, conserved barrel domain protein
GM418_RS29705	COG3237	CsbD-like
GM418_RS29720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GM418_RS29735	COG3237	CsbD-like
GM418_RS29760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GM418_RS29780	COG1127	ABC transporter
GM418_RS29955	COG3119	arylsulfatase activity
GM418_RS29980	COG4206	TonB-dependent receptor
GM418_RS29980	COG1629	transport
GM418_RS29995	COG4974	Belongs to the 'phage' integrase family
GM418_RS30000	COG4974	Belongs to the 'phage' integrase family
GM418_RS30070	COG3279	Response regulator of the LytR AlgR family
GM418_RS30075	COG3275	phosphorelay sensor kinase activity
GM418_RS30105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GM418_RS30265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GM418_RS30280	COG1139	Iron-sulfur cluster binding protein
GM418_RS30285	COG0247	lactate metabolic process
GM418_RS30315	COG4206	TonB-dependent receptor
GM418_RS30315	COG1629	transport
GM418_RS30325	COG1595	DNA-templated transcription, initiation
GM418_RS30345	COG2502	aspartate--ammonia ligase
GM418_RS30385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GM418_RS30385	COG0321	lipoyl(octanoyl) transferase activity
GM418_RS30425	COG3119	arylsulfatase activity
GM418_RS30470	COG3119	arylsulfatase activity
GM418_RS30485	COG4206	TonB-dependent receptor
GM418_RS30485	COG1629	transport
GM418_RS30490	COG1609	Transcriptional regulator
GM418_RS30495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GM418_RS30500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GM418_RS30510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GM418_RS30520	COG2731	YhcH YjgK YiaL family protein
GM418_RS30525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GM418_RS30530	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS30535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM418_RS30540	COG4948	Mandelate Racemase Muconate Lactonizing
GM418_RS30555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GM418_RS30565	COG1484	DNA-dependent DNA replication
GM418_RS30570	COG4584	PFAM Integrase catalytic
GM418_RS30620	COG4584	PFAM Integrase catalytic
GM418_RS30620	COG2390	Transcriptional regulator
GM418_RS30625	COG1484	DNA-dependent DNA replication
GM418_RS30700	COG1484	DNA-dependent DNA replication
GM418_RS30705	COG4584	PFAM Integrase catalytic
GM418_RS30765	COG3177	Filamentation induced by cAMP protein fic
GM418_RS30770	COG1943	Transposase
GM418_RS30775	COG2390	Transcriptional regulator
GM418_RS30775	COG4584	PFAM Integrase catalytic
GM418_RS30780	COG1484	DNA-dependent DNA replication
GM418_RS30860	COG0667	Aldo Keto reductase
GM418_RS30890	COG1489	DNA binding
GM418_RS30895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GM418_RS30910	COG0811	peptide transport
GM418_RS30925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GM418_RS30930	COG1752	Esterase of the alpha-beta hydrolase superfamily
GM418_RS30955	COG1418	mRNA catabolic process
GM418_RS31000	COG4690	dipeptidase activity
GM418_RS31005	COG0335	large ribosomal subunit rRNA binding
GM418_RS31010	COG0793	Belongs to the peptidase S41A family
GM418_RS31010	COG4946	Tricorn protease homolog
GM418_RS31015	COG2205	protein histidine kinase activity
GM418_RS31025	COG3119	arylsulfatase activity
GM418_RS31035	COG3119	arylsulfatase activity
GM418_RS31050	COG4206	TonB-dependent receptor
GM418_RS31050	COG1629	transport
GM418_RS31060	COG1595	DNA-templated transcription, initiation
GM418_RS31085	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GM418_RS31090	COG0737	Belongs to the 5'-nucleotidase family
GM418_RS31105	COG2205	protein histidine kinase activity
GM418_RS31110	COG0306	phosphate transporter
GM418_RS31145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GM418_RS31150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GM418_RS31165	COG1904	glucuronate isomerase
GM418_RS31185	COG1063	alcohol dehydrogenase
GM418_RS31200	COG0022	dehydrogenase e1 component
GM418_RS31215	COG3119	arylsulfatase activity
GM418_RS31230	COG1629	transport
GM418_RS31230	COG4206	TonB-dependent receptor
GM418_RS31260	COG1629	transport
GM418_RS31260	COG4206	TonB-dependent receptor
GM418_RS31285	COG2271	Major facilitator Superfamily
GM418_RS31290	COG0508	dehydrogenase complex catalyzes the overall conversion of
GM418_RS31295	COG1609	Transcriptional regulator
GM418_RS31300	COG1028	Short-chain dehydrogenase reductase Sdr
GM418_RS31305	COG0673	inositol 2-dehydrogenase activity
GM418_RS31320	COG0673	inositol 2-dehydrogenase activity
GM418_RS31325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GM418_RS31335	COG1063	alcohol dehydrogenase
GM418_RS31340	COG0534	Mate efflux family protein
GM418_RS31350	COG0439	Biotin carboxylase
GM418_RS31355	COG5016	pyruvate
GM418_RS31355	COG0511	ligase activity, forming carbon-carbon bonds
GM418_RS31360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GM418_RS31365	COG0360	Binds together with S18 to 16S ribosomal RNA
GM418_RS31370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GM418_RS31375	COG0359	binds to the 23S rRNA
GM418_RS31400	COG0251	oxidation-reduction process
GM418_RS31410	COG0860	N-Acetylmuramoyl-L-alanine amidase