locus-tag	class	description
TIB1ST10_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TIB1ST10_RS00010	COG0592	DNA-directed DNA polymerase activity
TIB1ST10_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TIB1ST10_RS00030	COG1132	(ABC) transporter
TIB1ST10_RS00045	COG1482	cell wall glycoprotein biosynthetic process
TIB1ST10_RS00050	COG0187	DNA topoisomerase II activity
TIB1ST10_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TIB1ST10_RS00065	COG0039	L-malate dehydrogenase activity
TIB1ST10_RS00070	COG1609	Transcriptional regulator
TIB1ST10_RS00075	COG1129	ABC transporter
TIB1ST10_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
TIB1ST10_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TIB1ST10_RS00095	COG1869	D-ribose catabolic process
TIB1ST10_RS00115	COG3775	system Galactitol-specific IIC component
TIB1ST10_RS00120	COG3414	Phosphotransferase system galactitol-specific IIB component
TIB1ST10_RS00125	COG1063	alcohol dehydrogenase
TIB1ST10_RS00160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TIB1ST10_RS00230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TIB1ST10_RS00250	COG4591	ABC-type transport system involved in lipoprotein release permease component
TIB1ST10_RS00255	COG0577	efflux transmembrane transporter activity
TIB1ST10_RS00255	COG1136	(ABC) transporter
TIB1ST10_RS00260	COG2197	response regulator
TIB1ST10_RS00270	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS00275	COG1175	transmembrane transport
TIB1ST10_RS00285	COG1349	DNA-binding transcription factor activity
TIB1ST10_RS00305	COG0546	phosphoglycolate phosphatase activity
TIB1ST10_RS00315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TIB1ST10_RS00325	COG4585	Histidine kinase
TIB1ST10_RS00330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TIB1ST10_RS00335	COG1309	transcriptional regulator
TIB1ST10_RS00340	COG2409	Drug exporters of the RND superfamily
TIB1ST10_RS00360	COG1136	(ABC) transporter
TIB1ST10_RS00375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TIB1ST10_RS00380	COG1120	ATPase activity
TIB1ST10_RS00395	COG0058	SHG alpha-glucan phosphorylase activity
TIB1ST10_RS00410	COG5426	von Willebrand factor, type A
TIB1ST10_RS00425	COG1175	transmembrane transport
TIB1ST10_RS00430	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS00455	COG0205	6-phosphofructokinase activity
TIB1ST10_RS00475	COG1027	Aspartate ammonia-lyase
TIB1ST10_RS00480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
TIB1ST10_RS00495	COG1132	(ABC) transporter
TIB1ST10_RS00500	COG1132	(ABC) transporter
TIB1ST10_RS00505	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TIB1ST10_RS00520	COG0641	radical SAM
TIB1ST10_RS00525	COG1120	ATPase activity
TIB1ST10_RS00540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TIB1ST10_RS00550	COG4716	Myosin-crossreactive antigen
TIB1ST10_RS00555	COG0351	phosphomethylpyrimidine kinase
TIB1ST10_RS00555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TIB1ST10_RS00555	COG0352	thiamine-phosphate diphosphorylase activity
TIB1ST10_RS00560	COG0352	thiamine-phosphate diphosphorylase activity
TIB1ST10_RS00580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TIB1ST10_RS00590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TIB1ST10_RS00640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TIB1ST10_RS00670	COG0438	transferase activity, transferring glycosyl groups
TIB1ST10_RS00705	COG3104	oligopeptide transport
TIB1ST10_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
TIB1ST10_RS00725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS00725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS00730	COG1105	Belongs to the carbohydrate kinase PfkB family
TIB1ST10_RS00740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TIB1ST10_RS00750	COG0438	transferase activity, transferring glycosyl groups
TIB1ST10_RS00760	COG0297	glycogen (starch) synthase activity
TIB1ST10_RS00780	COG1252	NADH dehydrogenase
TIB1ST10_RS00790	COG1643	Atp-dependent helicase
TIB1ST10_RS00795	COG4721	ABC-type cobalt transport system, permease component
TIB1ST10_RS00800	COG1129	ABC transporter
TIB1ST10_RS00820	COG0167	dihydroorotate dehydrogenase activity
TIB1ST10_RS00825	COG1013	pyruvate-flavodoxin oxidoreductase activity
TIB1ST10_RS00825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TIB1ST10_RS00825	COG0674	pyruvate-flavodoxin oxidoreductase activity
TIB1ST10_RS00825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TIB1ST10_RS00840	COG2186	Transcriptional regulator
TIB1ST10_RS00845	COG1620	l-lactate permease
TIB1ST10_RS00850	COG0247	lactate metabolic process
TIB1ST10_RS00855	COG1139	Iron-sulfur cluster binding protein
TIB1ST10_RS00860	COG1556	Lactate utilization protein
TIB1ST10_RS00865	COG1122	ATPase activity
TIB1ST10_RS00880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TIB1ST10_RS00885	COG4988	ABC transporter
TIB1ST10_RS00890	COG1294	oxidase, subunit
TIB1ST10_RS00895	COG1271	oxidase subunit
TIB1ST10_RS00925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TIB1ST10_RS00940	COG0515	serine threonine protein kinase
TIB1ST10_RS00940	COG2815	serine threonine protein kinase
TIB1ST10_RS00945	COG0768	penicillin binding
TIB1ST10_RS00960	COG1716	ATPase activity
TIB1ST10_RS01075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TIB1ST10_RS01080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TIB1ST10_RS01090	COG1136	(ABC) transporter
TIB1ST10_RS01090	COG0577	efflux transmembrane transporter activity
TIB1ST10_RS01105	COG0561	phosphatase activity
TIB1ST10_RS01110	COG0561	phosphatase activity
TIB1ST10_RS01115	COG3842	ATPase activity
TIB1ST10_RS01125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TIB1ST10_RS01130	COG3681	Belongs to the UPF0597 family
TIB1ST10_RS01135	COG0814	amino acid
TIB1ST10_RS01140	COG0673	inositol 2-dehydrogenase activity
TIB1ST10_RS01175	COG0494	nUDIX hydrolase
TIB1ST10_RS01185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TIB1ST10_RS01240	COG1111	helicase
TIB1ST10_RS01240	COG1205	dead DEAH box helicase
TIB1ST10_RS01245	COG2890	protein-(glutamine-N5) methyltransferase activity
TIB1ST10_RS01255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TIB1ST10_RS01255	COG1754	DNA topoisomerase type I activity
TIB1ST10_RS01265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TIB1ST10_RS01270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TIB1ST10_RS01280	COG1774	PSP1 C-terminal conserved region
TIB1ST10_RS01305	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TIB1ST10_RS01325	COG3458	cephalosporin-C deacetylase activity
TIB1ST10_RS01335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TIB1ST10_RS01345	COG0037	tRNA processing
TIB1ST10_RS01360	COG0302	gtp cyclohydrolase
TIB1ST10_RS01400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TIB1ST10_RS01405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TIB1ST10_RS01425	COG0649	NAD binding
TIB1ST10_RS01455	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TIB1ST10_RS01460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TIB1ST10_RS01465	COG1984	allophanate hydrolase subunit 2
TIB1ST10_RS01475	COG1090	epimerase
TIB1ST10_RS01480	COG0705	Rhomboid family
TIB1ST10_RS01490	COG2197	response regulator
TIB1ST10_RS01495	COG4585	Histidine kinase
TIB1ST10_RS01505	COG3711	transcriptional antiterminator
TIB1ST10_RS01510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TIB1ST10_RS01510	COG2190	(PTS) system
TIB1ST10_RS01510	COG1263	PTS System
TIB1ST10_RS01515	COG1263	PTS System
TIB1ST10_RS01515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TIB1ST10_RS01515	COG2190	(PTS) system
TIB1ST10_RS01520	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TIB1ST10_RS01530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TIB1ST10_RS01535	COG3395	kinase activity
TIB1ST10_RS01540	COG1349	DNA-binding transcription factor activity
TIB1ST10_RS01545	COG1194	a g-specific adenine glycosylase
TIB1ST10_RS01550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TIB1ST10_RS01555	COG0113	porphobilinogen synthase activity
TIB1ST10_RS01565	COG0181	hydroxymethylbilane synthase activity
TIB1ST10_RS01575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TIB1ST10_RS01580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TIB1ST10_RS01585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TIB1ST10_RS01585	COG3253	May function as heme-dependent peroxidase
TIB1ST10_RS01600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TIB1ST10_RS01605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TIB1ST10_RS01620	COG1082	Xylose isomerase domain protein TIM barrel
TIB1ST10_RS01625	COG0506	proline dehydrogenase activity
TIB1ST10_RS01640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TIB1ST10_RS01660	COG0406	alpha-ribazole phosphatase activity
TIB1ST10_RS01665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TIB1ST10_RS01670	COG0785	Cytochrome C biogenesis protein
TIB1ST10_RS01675	COG1333	cytochrome c biogenesis protein
TIB1ST10_RS01680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TIB1ST10_RS01690	COG4221	oxidoreductase activity
TIB1ST10_RS01715	COG1120	ATPase activity
TIB1ST10_RS01720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TIB1ST10_RS01730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TIB1ST10_RS01750	COG0406	alpha-ribazole phosphatase activity
TIB1ST10_RS01750	COG0494	nUDIX hydrolase
TIB1ST10_RS01755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TIB1ST10_RS01760	COG0745	RESPONSE REGULATOR receiver
TIB1ST10_RS01770	COG1490	D-aminoacyl-tRNA deacylase activity
TIB1ST10_RS01775	COG3485	protocatechuate 3,4-dioxygenase
TIB1ST10_RS01785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TIB1ST10_RS01795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TIB1ST10_RS01800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TIB1ST10_RS01805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TIB1ST10_RS01810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TIB1ST10_RS01825	COG1329	Transcriptional regulator
TIB1ST10_RS01835	COG0745	RESPONSE REGULATOR receiver
TIB1ST10_RS01860	COG0588	phosphoglycerate mutase activity
TIB1ST10_RS01875	COG0252	asparaginase activity
TIB1ST10_RS01880	COG1113	amino acid transport
TIB1ST10_RS01885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TIB1ST10_RS01890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TIB1ST10_RS01895	COG0800	Aldolase
TIB1ST10_RS01920	COG0673	inositol 2-dehydrogenase activity
TIB1ST10_RS01930	COG5492	domain, Protein
TIB1ST10_RS01945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TIB1ST10_RS01950	COG0215	cysteine-tRNA ligase activity
TIB1ST10_RS02005	COG3842	ATPase activity
TIB1ST10_RS02015	COG1760	l-serine dehydratase
TIB1ST10_RS02020	COG0673	inositol 2-dehydrogenase activity
TIB1ST10_RS02025	COG2182	Extracellular solute-binding protein
TIB1ST10_RS02030	COG1175	transmembrane transport
TIB1ST10_RS02035	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS02040	COG1063	alcohol dehydrogenase
TIB1ST10_RS02055	COG1174	glycine betaine transport
TIB1ST10_RS02080	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TIB1ST10_RS02085	COG2130	NADP-dependent
TIB1ST10_RS02090	COG1131	(ABC) transporter
TIB1ST10_RS02100	COG4585	Histidine kinase
TIB1ST10_RS02105	COG2197	response regulator
TIB1ST10_RS02110	COG0406	alpha-ribazole phosphatase activity
TIB1ST10_RS02115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TIB1ST10_RS02120	COG1492	cobalamin metabolic process
TIB1ST10_RS02140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TIB1ST10_RS02140	COG1648	precorrin-2 dehydrogenase activity
TIB1ST10_RS02155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TIB1ST10_RS02160	COG1120	ATPase activity
TIB1ST10_RS02180	COG0310	cobalt ion transport
TIB1ST10_RS02215	COG1797	cobyrinic acid a,c-diamide synthase activity
TIB1ST10_RS02220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TIB1ST10_RS02220	COG1648	precorrin-2 dehydrogenase activity
TIB1ST10_RS02225	COG2099	Precorrin-6x reductase
TIB1ST10_RS02230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TIB1ST10_RS02260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS02260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TIB1ST10_RS02260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS02280	COG1854	S-ribosylhomocysteine lyase activity
TIB1ST10_RS02300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TIB1ST10_RS02310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TIB1ST10_RS02320	COG3718	enzyme involved in inositol metabolism
TIB1ST10_RS02325	COG3962	Belongs to the TPP enzyme family
TIB1ST10_RS02340	COG1609	Transcriptional regulator
TIB1ST10_RS02350	COG1082	Xylose isomerase domain protein TIM barrel
TIB1ST10_RS02355	COG1082	Xylose isomerase domain protein TIM barrel
TIB1ST10_RS02360	COG0673	inositol 2-dehydrogenase activity
TIB1ST10_RS02365	COG2814	Major facilitator Superfamily
TIB1ST10_RS02375	COG1082	Xylose isomerase domain protein TIM barrel
TIB1ST10_RS02380	COG0673	inositol 2-dehydrogenase activity
TIB1ST10_RS02390	COG3142	Participates in the control of copper homeostasis
TIB1ST10_RS02400	COG1061	Type III restriction enzyme res subunit
TIB1ST10_RS02415	COG0363	glucosamine-6-phosphate deaminase activity
TIB1ST10_RS02420	COG1278	Cold shock
TIB1ST10_RS02435	COG2252	PERMEase
TIB1ST10_RS02450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TIB1ST10_RS02475	COG2814	Major facilitator Superfamily
TIB1ST10_RS02495	COG1970	mechanosensitive ion channel activity
TIB1ST10_RS02510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TIB1ST10_RS02515	COG0303	'Molybdopterin
TIB1ST10_RS02540	COG0315	cyclic pyranopterin monophosphate synthase activity
TIB1ST10_RS02560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TIB1ST10_RS02595	COG1140	nitrate reductase beta subunit
TIB1ST10_RS02615	COG0315	cyclic pyranopterin monophosphate synthase activity
TIB1ST10_RS02615	COG0521	Mo-molybdopterin cofactor biosynthetic process
TIB1ST10_RS02630	COG0437	4 iron, 4 sulfur cluster binding
TIB1ST10_RS02635	COG0243	molybdopterin cofactor binding
TIB1ST10_RS02645	COG2022	thiamine diphosphate biosynthetic process
TIB1ST10_RS02655	COG2022	thiamine diphosphate biosynthetic process
TIB1ST10_RS02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TIB1ST10_RS02660	COG0598	Magnesium transport protein CorA
TIB1ST10_RS02665	COG2233	PERMEase
TIB1ST10_RS02680	COG0084	hydrolase, TatD family'
TIB1ST10_RS02685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TIB1ST10_RS02690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TIB1ST10_RS02695	COG1846	Transcriptional regulator
TIB1ST10_RS02710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TIB1ST10_RS02715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TIB1ST10_RS02735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TIB1ST10_RS02740	COG0193	aminoacyl-tRNA hydrolase activity
TIB1ST10_RS02790	COG0148	phosphopyruvate hydratase activity
TIB1ST10_RS02855	COG1297	OPT oligopeptide transporter protein
TIB1ST10_RS02860	COG0667	Aldo Keto reductase
TIB1ST10_RS02865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TIB1ST10_RS02870	COG0733	neurotransmitter:sodium symporter activity
TIB1ST10_RS02875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TIB1ST10_RS02890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TIB1ST10_RS02905	COG1331	Highly conserved protein containing a thioredoxin domain
TIB1ST10_RS02910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TIB1ST10_RS02920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TIB1ST10_RS02930	COG1722	exodeoxyribonuclease VII activity
TIB1ST10_RS02935	COG1570	exodeoxyribonuclease VII activity
TIB1ST10_RS02945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TIB1ST10_RS02950	COG1322	Protein conserved in bacteria
TIB1ST10_RS02955	COG1362	aminopeptidase activity
TIB1ST10_RS02960	COG0012	GTP binding
TIB1ST10_RS02980	COG1846	Transcriptional regulator
TIB1ST10_RS02985	COG1764	response to oxidative stress
TIB1ST10_RS03000	COG2235	arginine
TIB1ST10_RS03005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TIB1ST10_RS03015	COG1438	arginine binding
TIB1ST10_RS03025	COG2716	regulation of RNA biosynthetic process
TIB1ST10_RS03030	COG0667	Aldo Keto reductase
TIB1ST10_RS03035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TIB1ST10_RS03040	COG0833	amino acid
TIB1ST10_RS03045	COG0366	Alpha amylase catalytic
TIB1ST10_RS03045	COG3103	Sh3 type 3 domain protein
TIB1ST10_RS03080	COG1404	Belongs to the peptidase S8 family
TIB1ST10_RS03085	COG2501	S4 domain
TIB1ST10_RS03090	COG1126	abc transporter atp-binding protein
TIB1ST10_RS03095	COG0765	amino acid transport
TIB1ST10_RS03120	COG1176	ABC-type spermidine putrescine transport system, permease component I
TIB1ST10_RS03125	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS03135	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
TIB1ST10_RS03155	COG1136	(ABC) transporter
TIB1ST10_RS03165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TIB1ST10_RS03175	COG0803	Belongs to the bacterial solute-binding protein 9 family
TIB1ST10_RS03190	COG1012	belongs to the aldehyde dehydrogenase family
TIB1ST10_RS03195	COG1063	alcohol dehydrogenase
TIB1ST10_RS03200	COG2376	Dihydroxyacetone kinase
TIB1ST10_RS03205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TIB1ST10_RS03215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TIB1ST10_RS03220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TIB1ST10_RS03225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TIB1ST10_RS03240	COG2171	N-acyltransferase activity
TIB1ST10_RS03245	COG1834	amidinotransferase
TIB1ST10_RS03255	COG0477	Major facilitator Superfamily
TIB1ST10_RS03280	COG0297	glycogen (starch) synthase activity
TIB1ST10_RS03285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TIB1ST10_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TIB1ST10_RS03300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TIB1ST10_RS03335	COG0006	proline dipeptidase activity
TIB1ST10_RS03360	COG4139	cobalamin transport
TIB1ST10_RS03365	COG1120	ATPase activity
TIB1ST10_RS03380	COG1966	Carbon starvation protein
TIB1ST10_RS03400	COG0174	glutamine synthetase
TIB1ST10_RS03410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TIB1ST10_RS03415	COG2966	Psort location CytoplasmicMembrane, score
TIB1ST10_RS03435	COG0174	glutamine synthetase
TIB1ST10_RS03445	COG0438	transferase activity, transferring glycosyl groups
TIB1ST10_RS03455	COG1263	PTS System
TIB1ST10_RS03460	COG2188	Transcriptional regulator
TIB1ST10_RS03465	COG1263	PTS System
TIB1ST10_RS03465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TIB1ST10_RS03470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TIB1ST10_RS03480	COG3477	response to acidic pH
TIB1ST10_RS03490	COG0488	(ABC) transporter
TIB1ST10_RS03525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TIB1ST10_RS03540	COG0321	lipoyl(octanoyl) transferase activity
TIB1ST10_RS03545	COG0508	dehydrogenase complex catalyzes the overall conversion of
TIB1ST10_RS03550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TIB1ST10_RS03585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TIB1ST10_RS03590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TIB1ST10_RS03605	COG1136	(ABC) transporter
TIB1ST10_RS03635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TIB1ST10_RS03640	COG0723	plastoquinol--plastocyanin reductase activity
TIB1ST10_RS03645	COG2010	Cytochrome c
TIB1ST10_RS03650	COG1845	cytochrome c oxidase, subunit III
TIB1ST10_RS03660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TIB1ST10_RS03675	COG0088	Forms part of the polypeptide exit tunnel
TIB1ST10_RS03695	COG0791	NLP P60 protein
TIB1ST10_RS03700	COG1940	carbohydrate kinase activity
TIB1ST10_RS03720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TIB1ST10_RS03725	COG1234	tRNA 3'-trailer cleavage
TIB1ST10_RS03735	COG2815	serine threonine protein kinase
TIB1ST10_RS03735	COG0515	serine threonine protein kinase
TIB1ST10_RS03750	COG0142	geranyltranstransferase activity
TIB1ST10_RS03760	COG0210	DNA helicase
TIB1ST10_RS03785	COG3265	gluconokinase activity
TIB1ST10_RS03800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TIB1ST10_RS03800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TIB1ST10_RS03805	COG0509	glycine decarboxylation via glycine cleavage system
TIB1ST10_RS03810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TIB1ST10_RS03830	COG0714	Associated with various cellular activities
TIB1ST10_RS03835	COG2001	Belongs to the MraZ family
TIB1ST10_RS03840	COG0275	rRNA processing
TIB1ST10_RS03850	COG0768	penicillin binding
TIB1ST10_RS03855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TIB1ST10_RS03860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TIB1ST10_RS03865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TIB1ST10_RS03870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TIB1ST10_RS03880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TIB1ST10_RS03885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TIB1ST10_RS03900	COG1496	oxidoreductase activity
TIB1ST10_RS03905	COG1799	cell septum assembly
TIB1ST10_RS03935	COG0469	pyruvate kinase activity
TIB1ST10_RS03940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TIB1ST10_RS03945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TIB1ST10_RS03970	COG0277	FAD linked oxidase domain protein
TIB1ST10_RS03985	COG0539	negative regulation of cytoplasmic translation
TIB1ST10_RS04000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TIB1ST10_RS04005	COG1120	ATPase activity
TIB1ST10_RS04010	COG4988	ABC transporter
TIB1ST10_RS04015	COG1132	(ABC) transporter
TIB1ST10_RS04020	COG0237	dephospho-CoA kinase activity
TIB1ST10_RS04030	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TIB1ST10_RS04050	COG1120	ATPase activity
TIB1ST10_RS04055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TIB1ST10_RS04070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TIB1ST10_RS04100	COG0556	nucleotide-excision repair
TIB1ST10_RS04140	COG0322	excinuclease ABC activity
TIB1ST10_RS04145	COG1660	Displays ATPase and GTPase activities
TIB1ST10_RS04150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TIB1ST10_RS04155	COG1481	regulation of sporulation
TIB1ST10_RS04160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TIB1ST10_RS04165	COG0126	phosphoglycerate kinase activity
TIB1ST10_RS04170	COG0149	triose-phosphate isomerase activity
TIB1ST10_RS04175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TIB1ST10_RS04185	COG0285	dihydrofolate synthase activity
TIB1ST10_RS04195	COG0105	UTP biosynthetic process
TIB1ST10_RS04210	COG1530	ribonuclease E activity
TIB1ST10_RS04215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TIB1ST10_RS04220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TIB1ST10_RS04230	COG1309	transcriptional regulator
TIB1ST10_RS04235	COG0477	Major facilitator Superfamily
TIB1ST10_RS04240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TIB1ST10_RS04245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TIB1ST10_RS04250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TIB1ST10_RS04260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TIB1ST10_RS04270	COG0406	alpha-ribazole phosphatase activity
TIB1ST10_RS04305	COG0488	(ABC) transporter
TIB1ST10_RS04310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TIB1ST10_RS04450	COG1735	metal-dependent hydrolase with the TIM-barrel fold
TIB1ST10_RS04475	COG2814	Major facilitator Superfamily
TIB1ST10_RS04480	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TIB1ST10_RS04485	COG0352	thiamine-phosphate diphosphorylase activity
TIB1ST10_RS04490	COG0039	L-malate dehydrogenase activity
TIB1ST10_RS04495	COG0281	malic enzyme
TIB1ST10_RS04520	COG0495	leucyl-tRNA aminoacylation
TIB1ST10_RS04525	COG1555	photosystem II stabilization
TIB1ST10_RS04525	COG1596	polysaccharide export
TIB1ST10_RS04545	COG0268	Binds directly to 16S ribosomal RNA
TIB1ST10_RS04555	COG0481	GTPase activity
TIB1ST10_RS04560	COG4948	Mandelate Racemase Muconate Lactonizing
TIB1ST10_RS04565	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TIB1ST10_RS04570	COG1169	isochorismate synthase
TIB1ST10_RS04585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TIB1ST10_RS04595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TIB1ST10_RS04600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TIB1ST10_RS04615	COG0483	inositol monophosphate 1-phosphatase activity
TIB1ST10_RS04620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TIB1ST10_RS04625	COG1420	regulation of RNA biosynthetic process
TIB1ST10_RS04630	COG0484	heat shock protein binding
TIB1ST10_RS04640	COG1063	alcohol dehydrogenase
TIB1ST10_RS04645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TIB1ST10_RS04645	COG2213	PTS system mannitol-specific
TIB1ST10_RS04655	COG0514	ATP-dependent DNA helicase (RecQ)
TIB1ST10_RS04660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TIB1ST10_RS04670	COG0343	queuine tRNA-ribosyltransferase activity
TIB1ST10_RS04675	COG4585	Histidine kinase
TIB1ST10_RS04680	COG2197	response regulator
TIB1ST10_RS04685	COG4152	abc transporter atp-binding protein
TIB1ST10_RS04695	COG1668	transmembrane transport
TIB1ST10_RS04730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TIB1ST10_RS04740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TIB1ST10_RS04745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TIB1ST10_RS04750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TIB1ST10_RS04755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TIB1ST10_RS04765	COG1381	Involved in DNA repair and RecF pathway recombination
TIB1ST10_RS04780	COG2197	response regulator
TIB1ST10_RS04790	COG0423	glycine-tRNA ligase activity
TIB1ST10_RS04800	COG1053	succinate dehydrogenase
TIB1ST10_RS04810	COG0778	Nitroreductase
TIB1ST10_RS04830	COG0358	DNA primase activity
TIB1ST10_RS04835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TIB1ST10_RS04850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TIB1ST10_RS04855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TIB1ST10_RS04870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TIB1ST10_RS04875	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TIB1ST10_RS04880	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TIB1ST10_RS04885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TIB1ST10_RS04890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TIB1ST10_RS04910	COG0561	phosphatase activity
TIB1ST10_RS04920	COG0714	Associated with various cellular activities
TIB1ST10_RS04940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TIB1ST10_RS04955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TIB1ST10_RS04960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TIB1ST10_RS04970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TIB1ST10_RS04980	COG2814	Major facilitator Superfamily
TIB1ST10_RS04990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TIB1ST10_RS05010	COG1335	isochorismatase
TIB1ST10_RS05015	COG0667	Aldo Keto reductase
TIB1ST10_RS05020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TIB1ST10_RS05025	COG0540	Belongs to the ATCase OTCase family
TIB1ST10_RS05030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TIB1ST10_RS05035	COG0505	Belongs to the CarA family
TIB1ST10_RS05040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TIB1ST10_RS05045	COG0543	2 iron, 2 sulfur cluster binding
TIB1ST10_RS05050	COG0167	dihydroorotate dehydrogenase activity
TIB1ST10_RS05055	COG0284	orotidine-5'-phosphate decarboxylase activity
TIB1ST10_RS05060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TIB1ST10_RS05070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TIB1ST10_RS05080	COG1058	Belongs to the CinA family
TIB1ST10_RS05080	COG1546	Belongs to the CinA family
TIB1ST10_RS05085	COG1396	sequence-specific DNA binding
TIB1ST10_RS05105	COG2137	regulation of response to DNA damage stimulus
TIB1ST10_RS05110	COG1418	mRNA catabolic process
TIB1ST10_RS05115	COG2017	converts alpha-aldose to the beta-anomer
TIB1ST10_RS05120	COG1288	antiporter activity
TIB1ST10_RS05125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TIB1ST10_RS05135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TIB1ST10_RS05140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TIB1ST10_RS05145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TIB1ST10_RS05155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TIB1ST10_RS05165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TIB1ST10_RS05170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TIB1ST10_RS05185	COG1643	Atp-dependent helicase
TIB1ST10_RS05190	COG1946	Acyl-CoA thioesterase
TIB1ST10_RS05195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TIB1ST10_RS05200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TIB1ST10_RS05210	COG1309	transcriptional regulator
TIB1ST10_RS05250	COG0187	DNA topoisomerase II activity
TIB1ST10_RS05255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
TIB1ST10_RS05265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TIB1ST10_RS05285	COG1435	thymidine kinase activity
TIB1ST10_RS05310	COG0756	dUTP diphosphatase activity
TIB1ST10_RS05330	COG0569	domain protein
TIB1ST10_RS05335	COG0531	amino acid
TIB1ST10_RS05340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TIB1ST10_RS05350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TIB1ST10_RS05355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TIB1ST10_RS05370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TIB1ST10_RS05380	COG2964	Protein conserved in bacteria
TIB1ST10_RS05390	COG1113	amino acid transport
TIB1ST10_RS05420	COG1064	alcohol dehydrogenase
TIB1ST10_RS05425	COG3850	Histidine kinase
TIB1ST10_RS05430	COG2197	response regulator
TIB1ST10_RS05435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TIB1ST10_RS05445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TIB1ST10_RS05470	COG0509	glycine decarboxylation via glycine cleavage system
TIB1ST10_RS05475	COG1716	ATPase activity
TIB1ST10_RS05495	COG1295	ribonuclease BN
TIB1ST10_RS05505	COG0205	6-phosphofructokinase activity
TIB1ST10_RS05515	COG0009	L-threonylcarbamoyladenylate synthase
TIB1ST10_RS05530	COG1739	Uncharacterized protein family UPF0029
TIB1ST10_RS05540	COG0443	Heat shock 70 kDa protein
TIB1ST10_RS05580	COG0033	Phosphoglucomutase
TIB1ST10_RS05590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TIB1ST10_RS05610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TIB1ST10_RS05625	COG0366	Alpha amylase catalytic
TIB1ST10_RS05640	COG0482	sulfurtransferase activity
TIB1ST10_RS05665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TIB1ST10_RS05670	COG0154	amidase activity
TIB1ST10_RS05675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TIB1ST10_RS05685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TIB1ST10_RS05705	COG0134	indole-3-glycerol-phosphate synthase activity
TIB1ST10_RS05710	COG0133	tryptophan synthase activity
TIB1ST10_RS05720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TIB1ST10_RS05725	COG0067	glutamate synthase
TIB1ST10_RS05725	COG0069	glutamate synthase activity
TIB1ST10_RS05725	COG0070	glutamate synthase
TIB1ST10_RS05740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TIB1ST10_RS05750	COG1737	Transcriptional regulator
TIB1ST10_RS05755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TIB1ST10_RS05770	COG2971	BadF BadG BcrA BcrD
TIB1ST10_RS05780	COG2723	6-phospho-beta-galactosidase activity
TIB1ST10_RS05790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TIB1ST10_RS05795	COG1447	Phosphotransferase system cellobiose-specific component IIA
TIB1ST10_RS05810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TIB1ST10_RS05815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TIB1ST10_RS05820	COG0131	Imidazoleglycerol-phosphate dehydratase
TIB1ST10_RS05825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TIB1ST10_RS05830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TIB1ST10_RS05835	COG0217	transcriptional regulatory protein
TIB1ST10_RS05840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TIB1ST10_RS05845	COG0632	four-way junction helicase activity
TIB1ST10_RS05850	COG2255	four-way junction helicase activity
TIB1ST10_RS05860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TIB1ST10_RS05865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TIB1ST10_RS05870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TIB1ST10_RS05880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TIB1ST10_RS05885	COG1196	nuclear chromosome segregation
TIB1ST10_RS05890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TIB1ST10_RS05895	COG0124	histidyl-tRNA synthetase
TIB1ST10_RS05925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TIB1ST10_RS05940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TIB1ST10_RS05945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TIB1ST10_RS05950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TIB1ST10_RS05955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TIB1ST10_RS05960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TIB1ST10_RS05965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TIB1ST10_RS05970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TIB1ST10_RS05985	COG2326	polyphosphate kinase activity
TIB1ST10_RS05990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TIB1ST10_RS05995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TIB1ST10_RS06005	COG0194	GDP metabolic process
TIB1ST10_RS06010	COG1758	RNA polymerase activity
TIB1ST10_RS06020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TIB1ST10_RS06030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TIB1ST10_RS06050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TIB1ST10_RS06070	COG1511	domain protein
TIB1ST10_RS06075	COG1129	ABC transporter
TIB1ST10_RS06085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TIB1ST10_RS06090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TIB1ST10_RS06100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TIB1ST10_RS06105	COG1160	GTP binding
TIB1ST10_RS06115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TIB1ST10_RS06125	COG0738	Major facilitator superfamily
TIB1ST10_RS06130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TIB1ST10_RS06145	COG0427	acetyl-CoA hydrolase
TIB1ST10_RS06160	COG1522	sequence-specific DNA binding
TIB1ST10_RS06170	COG1216	Glycosyl transferase, family 2
TIB1ST10_RS06200	COG1230	cation diffusion facilitator family transporter
TIB1ST10_RS06220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TIB1ST10_RS06225	COG2814	Major facilitator Superfamily
TIB1ST10_RS06230	COG1846	Transcriptional regulator
TIB1ST10_RS06255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TIB1ST10_RS06260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TIB1ST10_RS06265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TIB1ST10_RS06270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TIB1ST10_RS06275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TIB1ST10_RS06280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TIB1ST10_RS06285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TIB1ST10_RS06290	COG0356	it plays a direct role in the translocation of protons across the membrane
TIB1ST10_RS06305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TIB1ST10_RS06315	COG2890	protein-(glutamine-N5) methyltransferase activity
TIB1ST10_RS06320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TIB1ST10_RS06325	COG0254	rRNA binding
TIB1ST10_RS06335	COG0083	homoserine kinase activity
TIB1ST10_RS06340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TIB1ST10_RS06345	COG0460	homoserine dehydrogenase
TIB1ST10_RS06365	COG0508	dehydrogenase complex catalyzes the overall conversion of
TIB1ST10_RS06365	COG0567	Dehydrogenase, E1 component
TIB1ST10_RS06395	COG1595	DNA-templated transcription, initiation
TIB1ST10_RS06405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TIB1ST10_RS06410	COG1162	GTPase activity
TIB1ST10_RS06420	COG0483	inositol monophosphate 1-phosphatase activity
TIB1ST10_RS06425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TIB1ST10_RS06435	COG0444	Belongs to the ABC transporter superfamily
TIB1ST10_RS06440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TIB1ST10_RS06445	COG0601	transmembrane transport
TIB1ST10_RS06450	COG0747	negative chemotaxis
TIB1ST10_RS06615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TIB1ST10_RS06640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TIB1ST10_RS06650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TIB1ST10_RS06690	COG0513	Belongs to the DEAD box helicase family
TIB1ST10_RS06695	COG1113	amino acid transport
TIB1ST10_RS06700	COG0180	Tryptophanyl-tRNA synthetase
TIB1ST10_RS06705	COG0613	PHP domain protein
TIB1ST10_RS06710	COG2902	Dehydrogenase
TIB1ST10_RS06730	COG0653	protein targeting
TIB1ST10_RS06735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TIB1ST10_RS06745	COG5401	PFAM Sporulation and spore germination
TIB1ST10_RS06750	COG5002	protein histidine kinase activity
TIB1ST10_RS06755	COG0745	RESPONSE REGULATOR receiver
TIB1ST10_RS06760	COG1678	Uncharacterized ACR, COG1678
TIB1ST10_RS06805	COG0165	Argininosuccinate lyase
TIB1ST10_RS06815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TIB1ST10_RS06825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TIB1ST10_RS06830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TIB1ST10_RS06835	COG2177	Part of the ABC transporter FtsEX involved in
TIB1ST10_RS06840	COG2884	Cell division ATP-binding protein ftsE
TIB1ST10_RS06845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TIB1ST10_RS06860	COG1674	ftsk spoiiie
TIB1ST10_RS06880	COG1181	Belongs to the D-alanine--D-alanine ligase family
TIB1ST10_RS06890	COG0066	3-isopropylmalate dehydratase activity
TIB1ST10_RS06895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TIB1ST10_RS06900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TIB1ST10_RS06905	COG1414	Transcriptional regulator
TIB1ST10_RS06920	COG1266	CAAX protease self-immunity
TIB1ST10_RS06935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TIB1ST10_RS06940	COG0473	3-isopropylmalate dehydrogenase activity
TIB1ST10_RS06945	COG0473	3-isopropylmalate dehydrogenase activity
TIB1ST10_RS06955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TIB1ST10_RS06960	COG0440	acetolactate synthase activity
TIB1ST10_RS06970	COG0537	adenosine 5'-monophosphoramidase activity
TIB1ST10_RS06975	COG0107	imidazoleglycerol-phosphate synthase activity
TIB1ST10_RS06980	COG4581	dead DEAH box helicase
TIB1ST10_RS06985	COG0805	protein transport
TIB1ST10_RS06990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TIB1ST10_RS07010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TIB1ST10_RS07015	COG0545	Peptidyl-prolyl cis-trans isomerase
TIB1ST10_RS07035	COG4974	Belongs to the 'phage' integrase family
TIB1ST10_RS07040	COG0494	nUDIX hydrolase
TIB1ST10_RS07045	COG0504	CTP synthase activity
TIB1ST10_RS07060	COG0497	DNA recombination
TIB1ST10_RS07065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TIB1ST10_RS07080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TIB1ST10_RS07085	COG1122	ATPase activity
TIB1ST10_RS07090	COG1268	BioY protein
TIB1ST10_RS07095	COG0647	UMP catabolic process
TIB1ST10_RS07120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TIB1ST10_RS07135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TIB1ST10_RS07140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TIB1ST10_RS07140	COG0072	phenylalanine-tRNA ligase activity
TIB1ST10_RS07145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TIB1ST10_RS07155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TIB1ST10_RS07160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TIB1ST10_RS07165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TIB1ST10_RS07180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TIB1ST10_RS07185	COG0140	phosphoribosyl-ATP diphosphatase activity
TIB1ST10_RS07190	COG3201	nicotinamide mononucleotide transporter
TIB1ST10_RS07205	COG0667	Aldo Keto reductase
TIB1ST10_RS07210	COG0372	Belongs to the citrate synthase family
TIB1ST10_RS07215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TIB1ST10_RS07235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TIB1ST10_RS07250	COG0792	nuclease activity
TIB1ST10_RS07260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TIB1ST10_RS07265	COG0681	Belongs to the peptidase S26 family
TIB1ST10_RS07270	COG0335	large ribosomal subunit rRNA binding
TIB1ST10_RS07280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TIB1ST10_RS07285	COG1053	succinate dehydrogenase
TIB1ST10_RS07295	COG0336	Belongs to the RNA methyltransferase TrmD family
TIB1ST10_RS07300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TIB1ST10_RS07305	COG1837	Belongs to the UPF0109 family
TIB1ST10_RS07310	COG0228	four-way junction DNA binding
TIB1ST10_RS07360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TIB1ST10_RS07365	COG0571	ribonuclease III activity
TIB1ST10_RS07370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TIB1ST10_RS07390	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS07425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TIB1ST10_RS07445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TIB1ST10_RS07450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TIB1ST10_RS07455	COG0028	Belongs to the TPP enzyme family
TIB1ST10_RS07465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TIB1ST10_RS07470	COG1185	polyribonucleotide nucleotidyltransferase activity
TIB1ST10_RS07475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TIB1ST10_RS07495	COG0517	IMP dehydrogenase activity
TIB1ST10_RS07495	COG4175	Glycine betaine
TIB1ST10_RS07500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TIB1ST10_RS07530	COG3732	PTS system glucitol sorbitol-specific
TIB1ST10_RS07545	COG0371	Dehydrogenase
TIB1ST10_RS07550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TIB1ST10_RS07565	COG1131	(ABC) transporter
TIB1ST10_RS07570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TIB1ST10_RS07575	COG0195	Participates in both transcription termination and antitermination
TIB1ST10_RS07580	COG0779	Required for maturation of 30S ribosomal subunits
TIB1ST10_RS07590	COG0730	response to heat
TIB1ST10_RS07600	COG0442	prolyl-tRNA aminoacylation
TIB1ST10_RS07610	COG0803	Belongs to the bacterial solute-binding protein 9 family
TIB1ST10_RS07610	COG0803	Belongs to the bacterial solute-binding protein 9 family
TIB1ST10_RS07620	COG1121	(ABC) transporter
TIB1ST10_RS07625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TIB1ST10_RS07635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TIB1ST10_RS07650	COG0750	zinc metalloprotease
TIB1ST10_RS07655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TIB1ST10_RS07670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TIB1ST10_RS07675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TIB1ST10_RS07680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TIB1ST10_RS07690	COG0575	Belongs to the CDS family
TIB1ST10_RS07695	COG0233	cytoplasmic translational termination
TIB1ST10_RS07700	COG0528	UMP kinase activity
TIB1ST10_RS07705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TIB1ST10_RS07710	COG0052	Belongs to the universal ribosomal protein uS2 family
TIB1ST10_RS07715	COG4974	Belongs to the 'phage' integrase family
TIB1ST10_RS07730	COG0242	peptide deformylase activity
TIB1ST10_RS07755	COG1119	ATPase activity
TIB1ST10_RS07765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TIB1ST10_RS07785	COG2226	methyltransferase
TIB1ST10_RS07795	COG0488	(ABC) transporter
TIB1ST10_RS07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TIB1ST10_RS07830	COG0396	ATPase activity
TIB1ST10_RS07845	COG0719	Fe-S assembly protein
TIB1ST10_RS07860	COG1175	transmembrane transport
TIB1ST10_RS07865	COG3833	ABC-type maltose transport systems, permease component
TIB1ST10_RS07875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TIB1ST10_RS07880	COG1131	(ABC) transporter
TIB1ST10_RS07900	COG0109	protoheme IX farnesyltransferase activity
TIB1ST10_RS07915	COG0363	glucosamine-6-phosphate deaminase activity
TIB1ST10_RS07930	COG0525	valine-tRNA ligase activity
TIB1ST10_RS07940	COG4946	Tricorn protease homolog
TIB1ST10_RS07940	COG0793	Belongs to the peptidase S41A family
TIB1ST10_RS07945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TIB1ST10_RS07950	COG0740	serine-type endopeptidase activity
TIB1ST10_RS07955	COG0740	serine-type endopeptidase activity
TIB1ST10_RS07965	COG0544	peptidyl-prolyl cis-trans isomerase activity
TIB1ST10_RS08035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TIB1ST10_RS08050	COG3409	Peptidoglycan-binding domain 1 protein
TIB1ST10_RS08085	COG3617	BRO family, N-terminal domain
TIB1ST10_RS08095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TIB1ST10_RS08095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TIB1ST10_RS08150	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TIB1ST10_RS08175	COG1201	RNA secondary structure unwinding
TIB1ST10_RS08205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TIB1ST10_RS08205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TIB1ST10_RS08225	COG0698	ribose 5-phosphate isomerase
TIB1ST10_RS08230	COG4552	Acetyltransferase involved in intracellular survival and related
TIB1ST10_RS08235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TIB1ST10_RS08255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TIB1ST10_RS08260	COG0366	Alpha amylase catalytic
TIB1ST10_RS08285	COG1695	Transcriptional regulator
TIB1ST10_RS08300	COG0629	single-stranded DNA binding
TIB1ST10_RS08330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TIB1ST10_RS08340	COG1113	amino acid transport
TIB1ST10_RS08345	COG0515	serine threonine protein kinase
TIB1ST10_RS08350	COG1472	Belongs to the glycosyl hydrolase 3 family
TIB1ST10_RS08375	COG0587	DNA-directed DNA polymerase activity
TIB1ST10_RS08395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TIB1ST10_RS08475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TIB1ST10_RS08485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TIB1ST10_RS08490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TIB1ST10_RS08495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TIB1ST10_RS08500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TIB1ST10_RS08525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TIB1ST10_RS08555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TIB1ST10_RS08570	COG2835	tetraacyldisaccharide 4'-kinase activity
TIB1ST10_RS08605	COG0662	Cupin 2, conserved barrel domain protein
TIB1ST10_RS08605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TIB1ST10_RS08625	COG1316	TRANSCRIPTIONal
TIB1ST10_RS08650	COG3340	Belongs to the peptidase S51 family
TIB1ST10_RS08665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TIB1ST10_RS08675	COG0424	maF-like protein
TIB1ST10_RS08685	COG4221	oxidoreductase activity
TIB1ST10_RS08690	COG0351	phosphomethylpyrimidine kinase
TIB1ST10_RS08705	COG0598	Magnesium transport protein CorA
TIB1ST10_RS08715	COG4770	biotin carboxylase activity
TIB1ST10_RS08735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TIB1ST10_RS08750	COG0477	Major facilitator Superfamily
TIB1ST10_RS08760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TIB1ST10_RS08765	COG0328	RNA-DNA hybrid ribonuclease activity
TIB1ST10_RS08775	COG1079	Belongs to the binding-protein-dependent transport system permease family
TIB1ST10_RS08780	COG4603	Belongs to the binding-protein-dependent transport system permease family
TIB1ST10_RS08785	COG3845	ABC transporter
TIB1ST10_RS08790	COG1744	ABC transporter substrate-binding protein PnrA-like
TIB1ST10_RS08800	COG1253	flavin adenine dinucleotide binding
TIB1ST10_RS08820	COG0039	L-malate dehydrogenase activity
TIB1ST10_RS08825	COG1012	belongs to the aldehyde dehydrogenase family
TIB1ST10_RS08835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TIB1ST10_RS08855	COG0138	bifunctional purine biosynthesis protein purh
TIB1ST10_RS08865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TIB1ST10_RS08870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TIB1ST10_RS08870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TIB1ST10_RS08880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TIB1ST10_RS08880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TIB1ST10_RS08895	COG0045	succinate-CoA ligase (ADP-forming) activity
TIB1ST10_RS08905	COG1464	Belongs to the NlpA lipoprotein family
TIB1ST10_RS08910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TIB1ST10_RS08915	COG2011	ABC-type metal ion transport system permease component
TIB1ST10_RS08920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TIB1ST10_RS08935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TIB1ST10_RS08935	COG0519	Catalyzes the synthesis of GMP from XMP
TIB1ST10_RS08945	COG1045	serine acetyltransferase
TIB1ST10_RS08950	COG1605	Chorismate mutase
TIB1ST10_RS08950	COG0287	Prephenate dehydrogenase
TIB1ST10_RS08955	COG0516	GMP reductase activity
TIB1ST10_RS08970	COG1115	amino acid carrier protein
TIB1ST10_RS08980	COG0459	protein refolding
TIB1ST10_RS08985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TIB1ST10_RS09010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TIB1ST10_RS09015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TIB1ST10_RS09030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TIB1ST10_RS09035	COG0456	acetyltransferase
TIB1ST10_RS09045	COG0802	atpase or kinase
TIB1ST10_RS09055	COG0513	Belongs to the DEAD box helicase family
TIB1ST10_RS09070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TIB1ST10_RS09070	COG0438	transferase activity, transferring glycosyl groups
TIB1ST10_RS09080	COG0736	holo-[acyl-carrier-protein] synthase activity
TIB1ST10_RS09085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TIB1ST10_RS09100	COG1072	(Pantothenic acid kinase))
TIB1ST10_RS09110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TIB1ST10_RS09115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TIB1ST10_RS09120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TIB1ST10_RS09140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TIB1ST10_RS09145	COG0101	tRNA pseudouridine synthase activity
TIB1ST10_RS09160	COG3845	ABC transporter
TIB1ST10_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
TIB1ST10_RS09205	COG2271	Major facilitator Superfamily
TIB1ST10_RS09215	COG0438	transferase activity, transferring glycosyl groups
TIB1ST10_RS09220	COG0203	ribosomal protein L17
TIB1ST10_RS09225	COG0202	RNA polymerase activity
TIB1ST10_RS09230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TIB1ST10_RS09235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TIB1ST10_RS09240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TIB1ST10_RS09245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TIB1ST10_RS09250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TIB1ST10_RS09260	COG0563	adenylate kinase activity
TIB1ST10_RS09280	COG0584	glycerophosphoryl diester phosphodiesterase
TIB1ST10_RS09295	COG0200	Binds to the 23S rRNA
TIB1ST10_RS09300	COG1841	ribosomal large subunit assembly
TIB1ST10_RS09305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TIB1ST10_RS09310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TIB1ST10_RS09315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TIB1ST10_RS09320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TIB1ST10_RS09325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TIB1ST10_RS09330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TIB1ST10_RS09335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TIB1ST10_RS09340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TIB1ST10_RS09345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TIB1ST10_RS09350	COG0255	Belongs to the universal ribosomal protein uL29 family
TIB1ST10_RS09355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TIB1ST10_RS09360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TIB1ST10_RS09365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TIB1ST10_RS09370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TIB1ST10_RS09375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TIB1ST10_RS09380	COG0089	rRNA binding
TIB1ST10_RS09385	COG0088	Forms part of the polypeptide exit tunnel
TIB1ST10_RS09390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TIB1ST10_RS09395	COG0051	transcription antitermination factor activity, RNA binding
TIB1ST10_RS09405	COG0156	8-amino-7-oxononanoate synthase activity
TIB1ST10_RS09420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TIB1ST10_RS09425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TIB1ST10_RS09430	COG0737	Belongs to the 5'-nucleotidase family
TIB1ST10_RS09440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TIB1ST10_RS09450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TIB1ST10_RS09455	COG0049	tRNA binding
TIB1ST10_RS09460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TIB1ST10_RS09490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TIB1ST10_RS09495	COG0085	RNA polymerase activity
TIB1ST10_RS09500	COG0222	ribosome binding
TIB1ST10_RS09505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TIB1ST10_RS09510	COG0081	regulation of translation
TIB1ST10_RS09515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TIB1ST10_RS09520	COG0250	Participates in transcription elongation, termination and antitermination
TIB1ST10_RS09525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TIB1ST10_RS09535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TIB1ST10_RS09540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TIB1ST10_RS09550	COG2030	dehydratase
TIB1ST10_RS09555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TIB1ST10_RS09575	COG0708	Exodeoxyribonuclease III
TIB1ST10_RS09580	COG1024	Enoyl-CoA hydratase
TIB1ST10_RS09590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TIB1ST10_RS09595	COG0649	NAD binding
TIB1ST10_RS09600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TIB1ST10_RS09605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TIB1ST10_RS09605	COG0674	pyruvate-flavodoxin oxidoreductase activity
TIB1ST10_RS09610	COG1013	pyruvate-flavodoxin oxidoreductase activity
TIB1ST10_RS09635	COG3590	peptidase
TIB1ST10_RS09645	COG1126	abc transporter atp-binding protein
TIB1ST10_RS09660	COG1131	(ABC) transporter
TIB1ST10_RS09680	COG2301	Belongs to the HpcH HpaI aldolase family
TIB1ST10_RS09690	COG0142	geranyltranstransferase activity
TIB1ST10_RS09695	COG1007	ATP synthesis coupled electron transport
TIB1ST10_RS09710	COG0713	ATP synthesis coupled electron transport
TIB1ST10_RS09720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TIB1ST10_RS09725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TIB1ST10_RS09730	COG1034	ATP synthesis coupled electron transport
TIB1ST10_RS09735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TIB1ST10_RS09745	COG0649	NAD binding
TIB1ST10_RS09750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TIB1ST10_RS09755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TIB1ST10_RS09765	COG0644	oxidoreductase
TIB1ST10_RS09790	COG2226	methyltransferase
TIB1ST10_RS09810	COG2376	Dihydroxyacetone kinase
TIB1ST10_RS09815	COG1461	Dihydroxyacetone kinase
TIB1ST10_RS09820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TIB1ST10_RS09820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TIB1ST10_RS09820	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
TIB1ST10_RS09830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TIB1ST10_RS09840	COG0039	L-malate dehydrogenase activity
TIB1ST10_RS09870	COG1175	transmembrane transport
TIB1ST10_RS09875	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS09910	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS09915	COG1175	transmembrane transport
TIB1ST10_RS09935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TIB1ST10_RS09950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TIB1ST10_RS09975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TIB1ST10_RS09995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TIB1ST10_RS10020	COG0047	phosphoribosylformylglycinamidine synthase activity
TIB1ST10_RS10025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TIB1ST10_RS10045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TIB1ST10_RS10050	COG0151	Belongs to the GarS family
TIB1ST10_RS10055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TIB1ST10_RS10065	COG2188	Transcriptional regulator
TIB1ST10_RS10070	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TIB1ST10_RS10075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TIB1ST10_RS10095	COG1217	gtp-binding protein TYPA
TIB1ST10_RS10125	COG0840	transmembrane signaling receptor activity
TIB1ST10_RS10135	COG0191	fructose-bisphosphate aldolase activity
TIB1ST10_RS10150	COG0586	Pfam SNARE associated Golgi protein
TIB1ST10_RS10175	COG0477	Major facilitator Superfamily
TIB1ST10_RS10180	COG0542	response to heat
TIB1ST10_RS10195	COG3588	fructose-bisphosphate aldolase
TIB1ST10_RS10210	COG4585	Histidine kinase
TIB1ST10_RS10215	COG2197	response regulator
TIB1ST10_RS10220	COG1136	(ABC) transporter
TIB1ST10_RS10220	COG4591	ABC-type transport system involved in lipoprotein release permease component
TIB1ST10_RS10225	COG1136	(ABC) transporter
TIB1ST10_RS10225	COG0577	efflux transmembrane transporter activity
TIB1ST10_RS10230	COG1051	belongs to the nudix hydrolase family
TIB1ST10_RS10235	COG1113	amino acid transport
TIB1ST10_RS10240	COG0569	domain protein
TIB1ST10_RS10240	COG2985	domain, Protein
TIB1ST10_RS10245	COG1063	alcohol dehydrogenase
TIB1ST10_RS10255	COG0789	Transcriptional regulator
TIB1ST10_RS10260	COG0484	heat shock protein binding
TIB1ST10_RS10265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TIB1ST10_RS10285	COG0745	RESPONSE REGULATOR receiver
TIB1ST10_RS10295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TIB1ST10_RS10310	COG0574	Belongs to the PEP-utilizing enzyme family
TIB1ST10_RS10310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TIB1ST10_RS10315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TIB1ST10_RS10325	COG0560	Phosphoserine phosphatase
TIB1ST10_RS10325	COG3830	Belongs to the UPF0237 family
TIB1ST10_RS10330	COG0676	glucose-6-phosphate 1-epimerase activity
TIB1ST10_RS10340	COG0154	amidase activity
TIB1ST10_RS10345	COG1609	Transcriptional regulator
TIB1ST10_RS10370	COG1175	transmembrane transport
TIB1ST10_RS10375	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS10390	COG0747	negative chemotaxis
TIB1ST10_RS10395	COG0601	transmembrane transport
TIB1ST10_RS10400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TIB1ST10_RS10470	COG1132	(ABC) transporter
TIB1ST10_RS10470	COG2375	cellular response to nickel ion
TIB1ST10_RS10480	COG1129	ABC transporter
TIB1ST10_RS10515	COG1131	(ABC) transporter
TIB1ST10_RS10520	COG0508	dehydrogenase complex catalyzes the overall conversion of
TIB1ST10_RS10525	COG0022	dehydrogenase e1 component
TIB1ST10_RS10535	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TIB1ST10_RS10540	COG0535	radical SAM domain protein
TIB1ST10_RS10560	COG1132	(ABC) transporter
TIB1ST10_RS10580	COG2378	regulation of single-species biofilm formation
TIB1ST10_RS10590	COG3415	Transposase
TIB1ST10_RS10590	COG2801	Transposase and inactivated derivatives
TIB1ST10_RS10635	COG2205	protein histidine kinase activity
TIB1ST10_RS10650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TIB1ST10_RS10665	COG1902	pentaerythritol trinitrate reductase activity
TIB1ST10_RS10675	COG0477	Major facilitator Superfamily
TIB1ST10_RS10680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TIB1ST10_RS10680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TIB1ST10_RS10685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TIB1ST10_RS10715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TIB1ST10_RS10720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TIB1ST10_RS10730	COG0018	arginyl-trna synthetase
TIB1ST10_RS10735	COG0656	L-ascorbic acid biosynthetic process
TIB1ST10_RS10745	COG0166	Belongs to the GPI family
TIB1ST10_RS10760	COG0783	Belongs to the Dps family
TIB1ST10_RS10765	COG4581	dead DEAH box helicase
TIB1ST10_RS10770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TIB1ST10_RS10780	COG1881	PFAM PEBP family protein
TIB1ST10_RS10820	COG0701	Predicted permease
TIB1ST10_RS10840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TIB1ST10_RS10845	COG1408	metallophosphoesterase
TIB1ST10_RS10855	COG0693	protein deglycase activity
TIB1ST10_RS10860	COG0747	negative chemotaxis
TIB1ST10_RS10865	COG0601	transmembrane transport
TIB1ST10_RS10870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TIB1ST10_RS10880	COG4608	Belongs to the ABC transporter superfamily
TIB1ST10_RS10885	COG0254	rRNA binding
TIB1ST10_RS10890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TIB1ST10_RS10895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TIB1ST10_RS10900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TIB1ST10_RS10915	COG1472	Belongs to the glycosyl hydrolase 3 family
TIB1ST10_RS10925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TIB1ST10_RS10930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TIB1ST10_RS10940	COG1228	amidohydrolase
TIB1ST10_RS10945	COG2986	histidine ammonia-lyase
TIB1ST10_RS10950	COG1518	maintenance of DNA repeat elements
TIB1ST10_RS10960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TIB1ST10_RS10975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TIB1ST10_RS11025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TIB1ST10_RS11045	COG3158	transport of potassium into the cell
TIB1ST10_RS11050	COG0505	Belongs to the CarA family
TIB1ST10_RS11075	COG1609	Transcriptional regulator
TIB1ST10_RS11080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TIB1ST10_RS11120	COG0137	argininosuccinate synthase activity
TIB1ST10_RS11145	COG0561	phosphatase activity
TIB1ST10_RS11185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TIB1ST10_RS11190	COG0644	oxidoreductase
TIB1ST10_RS11205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TIB1ST10_RS11225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TIB1ST10_RS11240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TIB1ST10_RS11255	COG1968	undecaprenyl-diphosphatase activity
TIB1ST10_RS11260	COG1528	Iron-storage protein
TIB1ST10_RS11275	COG0359	binds to the 23S rRNA
TIB1ST10_RS11280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TIB1ST10_RS11290	COG0360	Binds together with S18 to 16S ribosomal RNA
TIB1ST10_RS11305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TIB1ST10_RS11305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS11305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS11310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS11310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TIB1ST10_RS11310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TIB1ST10_RS11320	COG1022	Amp-dependent synthetase and ligase
TIB1ST10_RS11345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TIB1ST10_RS11355	COG2608	mercury ion transmembrane transporter activity
TIB1ST10_RS11360	COG1937	Protein conserved in bacteria
TIB1ST10_RS11365	COG0305	Participates in initiation and elongation during chromosome replication
TIB1ST10_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
TIB1ST10_RS11370	COG0604	alcohol dehydrogenase
TIB1ST10_RS11370	COG3321	synthase
TIB1ST10_RS11380	COG2094	Belongs to the DNA glycosylase MPG family
TIB1ST10_RS11395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TIB1ST10_RS11400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TIB1ST10_RS11415	COG1113	amino acid transport
TIB1ST10_RS11435	COG0534	Mate efflux family protein
TIB1ST10_RS11450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TIB1ST10_RS11475	COG0205	6-phosphofructokinase activity
TIB1ST10_RS11480	COG0686	Belongs to the AlaDH PNT family
TIB1ST10_RS11485	COG1113	amino acid transport
TIB1ST10_RS11495	COG1376	ErfK ybiS ycfS ynhG family protein
TIB1ST10_RS11500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TIB1ST10_RS11510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TIB1ST10_RS11515	COG0686	Belongs to the AlaDH PNT family
TIB1ST10_RS11545	COG5012	cobalamin binding
TIB1ST10_RS11555	COG3457	Alanine racemase
TIB1ST10_RS11560	COG1113	amino acid transport
TIB1ST10_RS11565	COG1113	amino acid transport
TIB1ST10_RS11570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TIB1ST10_RS11575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TIB1ST10_RS11580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TIB1ST10_RS11600	COG0114	fumarate hydratase activity
TIB1ST10_RS11605	COG0395	ABC-type sugar transport system, permease component
TIB1ST10_RS11610	COG1175	transmembrane transport
TIB1ST10_RS11630	COG0668	transmembrane transport
TIB1ST10_RS11635	COG1929	Belongs to the glycerate kinase type-1 family
TIB1ST10_RS11645	COG0617	tRNA 3'-terminal CCA addition
TIB1ST10_RS11655	COG0515	serine threonine protein kinase
TIB1ST10_RS11660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TIB1ST10_RS11665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TIB1ST10_RS11675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TIB1ST10_RS11680	COG3534	alpha-L-arabinofuranosidase
TIB1ST10_RS11685	COG0492	ferredoxin-NADP+ reductase activity
TIB1ST10_RS11700	COG0657	acetylesterase activity
TIB1ST10_RS11710	COG3118	belongs to the thioredoxin family
TIB1ST10_RS11715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TIB1ST10_RS11740	COG0371	Dehydrogenase
TIB1ST10_RS11745	COG1069	ribulokinase activity
TIB1ST10_RS11760	COG0698	ribose 5-phosphate isomerase
TIB1ST10_RS11770	COG1349	DNA-binding transcription factor activity
TIB1ST10_RS11775	COG1312	Catalyzes the dehydration of D-mannonate
TIB1ST10_RS11780	COG0246	Mannitol dehydrogenase
TIB1ST10_RS11785	COG1904	glucuronate isomerase
TIB1ST10_RS11790	COG1609	Transcriptional regulator
TIB1ST10_RS11795	COG2211	Major facilitator Superfamily
TIB1ST10_RS11805	COG3250	beta-galactosidase activity
TIB1ST10_RS11820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TIB1ST10_RS11825	COG1181	Belongs to the D-alanine--D-alanine ligase family
TIB1ST10_RS11835	COG2814	Major facilitator Superfamily
TIB1ST10_RS11840	COG1475	DNA binding
TIB1ST10_RS11855	COG0357	Ribosomal RNA small subunit methyltransferase G
TIB1ST10_RS11885	COG0706	membrane insertase activity
TIB1ST10_RS11890	COG0594	ribonuclease P activity
TIB1ST10_RS11895	COG0230	Belongs to the bacterial ribosomal protein bL34 family