locus-tag	class	description
PAES_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PAES_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PAES_RS00025	COG0426	domain, Protein
PAES_RS00035	COG0445	tRNA wobble uridine modification
PAES_RS00050	COG2863	cytochrome
PAES_RS00055	COG0446	pyridine nucleotide-disulphide oxidoreductase
PAES_RS00060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PAES_RS00065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PAES_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PAES_RS00075	COG0187	DNA topoisomerase II activity
PAES_RS00080	COG0792	nuclease activity
PAES_RS00085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PAES_RS00095	COG1530	ribonuclease E activity
PAES_RS00100	COG2171	N-acyltransferase activity
PAES_RS00105	COG0793	Belongs to the peptidase S41A family
PAES_RS00115	COG0644	oxidoreductase
PAES_RS00120	COG0423	glycine-tRNA ligase activity
PAES_RS00130	COG0425	Belongs to the sulfur carrier protein TusA family
PAES_RS00135	COG1797	cobyrinic acid a,c-diamide synthase activity
PAES_RS00140	COG2920	part of a sulfur-relay system
PAES_RS00145	COG2221	Nitrite and sulphite reductase 4Fe-4S
PAES_RS00150	COG2221	Nitrite and sulphite reductase 4Fe-4S
PAES_RS00155	COG0493	'glutamate synthase
PAES_RS00165	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PAES_RS00170	COG2923	Belongs to the DsrF TusC family
PAES_RS00200	COG0437	4 iron, 4 sulfur cluster binding
PAES_RS00210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PAES_RS00210	COG1648	precorrin-2 dehydrogenase activity
PAES_RS00240	COG1619	proteins homologs of microcin C7 resistance protein MccF
PAES_RS00250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PAES_RS00260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PAES_RS00265	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PAES_RS00275	COG3360	Dodecin
PAES_RS00300	COG2210	Belongs to the sulfur carrier protein TusA family
PAES_RS00305	COG0514	ATP-dependent DNA helicase (RecQ)
PAES_RS00380	COG2963	transposase activity
PAES_RS00400	COG2890	protein-(glutamine-N5) methyltransferase activity
PAES_RS00410	COG3344	reverse transcriptase
PAES_RS00425	COG2824	Alkylphosphonate utilization operon protein PhnA
PAES_RS00440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PAES_RS00450	COG2111	Na H antiporter
PAES_RS00450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PAES_RS00455	COG2111	Na H antiporter
PAES_RS00460	COG1006	Multisubunit Na H antiporter MnhC subunit
PAES_RS00465	COG0651	ATP synthesis coupled electron transport
PAES_RS00470	COG1863	multisubunit Na H antiporter MnhE subunit
PAES_RS00475	COG2212	antiporter activity
PAES_RS00480	COG1320	monovalent cation:proton antiporter activity
PAES_RS00510	COG2233	PERMEase
PAES_RS00515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PAES_RS00530	COG2249	NAD(P)H dehydrogenase (quinone) activity
PAES_RS00540	COG1363	Peptidase, m42
PAES_RS00545	COG2918	glutathione biosynthetic process
PAES_RS00545	COG1181	Belongs to the D-alanine--D-alanine ligase family
PAES_RS00545	COG0189	ligase activity
PAES_RS00550	COG0367	asparagine synthase
PAES_RS00555	COG0003	Pfam Anion-transporting ATPase
PAES_RS00560	COG0778	Nitroreductase
PAES_RS00565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PAES_RS00575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PAES_RS00585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PAES_RS00595	COG1254	Belongs to the acylphosphatase family
PAES_RS00600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PAES_RS00605	COG0284	orotidine-5'-phosphate decarboxylase activity
PAES_RS00610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PAES_RS00615	COG1090	epimerase
PAES_RS00620	COG0724	RNA recognition motif
PAES_RS00625	COG0004	ammonium transporteR
PAES_RS00645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PAES_RS00655	COG0802	atpase or kinase
PAES_RS00660	COG1214	PFAM Peptidase M22, glycoprotease
PAES_RS00665	COG0799	negative regulation of ribosome biogenesis
PAES_RS00680	COG0504	CTP synthase activity
PAES_RS00735	COG1796	DNA polymerase
PAES_RS00735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PAES_RS00745	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PAES_RS00785	COG0859	PFAM glycosyl transferase family 9
PAES_RS00790	COG0708	Exodeoxyribonuclease III
PAES_RS00795	COG0360	Binds together with S18 to 16S ribosomal RNA
PAES_RS00800	COG0629	single-stranded DNA binding
PAES_RS00805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PAES_RS00810	COG0359	binds to the 23S rRNA
PAES_RS00820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PAES_RS00825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PAES_RS00830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PAES_RS00835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PAES_RS00840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PAES_RS00845	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PAES_RS00860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PAES_RS00865	COG0571	ribonuclease III activity
PAES_RS00870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PAES_RS00875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PAES_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
PAES_RS00885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PAES_RS00890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PAES_RS00895	COG0416	fatty acid biosynthetic process
PAES_RS00900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PAES_RS00920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PAES_RS00935	COG1121	(ABC) transporter
PAES_RS00940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PAES_RS00960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PAES_RS00965	COG1993	acr, cog1993
PAES_RS00970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PAES_RS00975	COG1381	Involved in DNA repair and RecF pathway recombination
PAES_RS01030	COG0791	NLP P60 protein
PAES_RS01035	COG0739	heme binding
PAES_RS01045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PAES_RS01050	COG0366	Alpha amylase catalytic
PAES_RS01055	COG0366	Alpha amylase catalytic
PAES_RS01075	COG3956	TIGRFAM MazG family protein
PAES_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
PAES_RS01085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PAES_RS01090	COG0736	holo-[acyl-carrier-protein] synthase activity
PAES_RS01100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PAES_RS01110	COG0003	Pfam Anion-transporting ATPase
PAES_RS01135	COG0702	epimerase
PAES_RS01140	COG2226	methyltransferase
PAES_RS01160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PAES_RS01165	COG3876	Protein conserved in bacteria
PAES_RS01170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PAES_RS01195	COG1937	Protein conserved in bacteria
PAES_RS01225	COG3453	Protein conserved in bacteria
PAES_RS01225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PAES_RS01240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PAES_RS01245	COG2048	Heterodisulfide reductase, subunit B
PAES_RS01250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PAES_RS01255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PAES_RS01260	COG0589	response to stress
PAES_RS01265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PAES_RS01270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PAES_RS01290	COG0083	homoserine kinase activity
PAES_RS01295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PAES_RS01300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PAES_RS01310	COG1058	Belongs to the CinA family
PAES_RS01310	COG1546	Belongs to the CinA family
PAES_RS01320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PAES_RS01335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PAES_RS01340	COG1131	(ABC) transporter
PAES_RS01350	COG1355	regulation of microtubule-based process
PAES_RS01355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PAES_RS01370	COG1216	Glycosyl transferase, family 2
PAES_RS01375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PAES_RS01380	COG0148	phosphopyruvate hydratase activity
PAES_RS01390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PAES_RS01395	COG4221	oxidoreductase activity
PAES_RS01425	COG0250	Participates in transcription elongation, termination and antitermination
PAES_RS01430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PAES_RS01435	COG0081	regulation of translation
PAES_RS01440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PAES_RS01445	COG0222	ribosome binding
PAES_RS01450	COG0085	RNA polymerase activity
PAES_RS01455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PAES_RS01460	COG0439	Biotin carboxylase
PAES_RS01465	COG0511	ligase activity, forming carbon-carbon bonds
PAES_RS01470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PAES_RS01480	COG0825	malonyl-CoA metabolic process
PAES_RS01485	COG1013	pyruvate-flavodoxin oxidoreductase activity
PAES_RS01490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PAES_RS01490	COG0674	pyruvate-flavodoxin oxidoreductase activity
PAES_RS01515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PAES_RS01535	COG4804	nuclease activity
PAES_RS01550	COG1674	ftsk spoiiie
PAES_RS01555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PAES_RS01565	COG0446	pyridine nucleotide-disulphide oxidoreductase
PAES_RS01570	COG3830	Belongs to the UPF0237 family
PAES_RS01570	COG0560	Phosphoserine phosphatase
PAES_RS01575	COG0519	Catalyzes the synthesis of GMP from XMP
PAES_RS01575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PAES_RS01580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PAES_RS01585	COG2267	carboxylic ester hydrolase activity
PAES_RS01645	COG1660	Displays ATPase and GTPase activities
PAES_RS01655	COG0542	response to heat
PAES_RS01660	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PAES_RS01670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PAES_RS01675	COG0552	protein localization to endoplasmic reticulum
PAES_RS01685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PAES_RS01690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PAES_RS01695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PAES_RS01700	COG0305	Participates in initiation and elongation during chromosome replication
PAES_RS01705	COG1573	uracil-dna glycosylase
PAES_RS01710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PAES_RS01720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PAES_RS01720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PAES_RS01745	COG1132	(ABC) transporter
PAES_RS01750	COG1215	transferase activity, transferring glycosyl groups
PAES_RS01765	COG0438	transferase activity, transferring glycosyl groups
PAES_RS01785	COG0438	transferase activity, transferring glycosyl groups
PAES_RS01790	COG0438	transferase activity, transferring glycosyl groups
PAES_RS01810	COG0575	Belongs to the CDS family
PAES_RS01815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAES_RS01820	COG0124	histidyl-tRNA synthetase
PAES_RS01835	COG0779	Required for maturation of 30S ribosomal subunits
PAES_RS01840	COG0195	Participates in both transcription termination and antitermination
PAES_RS01845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PAES_RS01850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PAES_RS01855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PAES_RS01860	COG0196	riboflavin kinase activity
PAES_RS01865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PAES_RS01870	COG1561	YicC-like family, N-terminal region
PAES_RS01875	COG0194	GDP metabolic process
PAES_RS01890	COG0205	6-phosphofructokinase activity
PAES_RS01900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PAES_RS01905	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PAES_RS01920	COG0758	DNA mediated transformation
PAES_RS01930	COG1304	FMN binding
PAES_RS01940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PAES_RS01945	COG1132	(ABC) transporter
PAES_RS01950	COG0268	Binds directly to 16S ribosomal RNA
PAES_RS01955	COG0632	four-way junction helicase activity
PAES_RS01985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PAES_RS01990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PAES_RS01995	COG2086	electron transfer activity
PAES_RS02000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PAES_RS02025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PAES_RS02030	COG0154	amidase activity
PAES_RS02035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PAES_RS02075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PAES_RS02080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PAES_RS02090	COG0725	ABC transporter, periplasmic molybdate-binding protein
PAES_RS02105	COG3842	ATPase activity
PAES_RS02115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PAES_RS02140	COG1136	(ABC) transporter
PAES_RS02150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PAES_RS02160	COG2226	methyltransferase
PAES_RS02165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PAES_RS02170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PAES_RS02195	COG0493	'glutamate synthase
PAES_RS02205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PAES_RS02210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PAES_RS02215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PAES_RS02220	COG1187	pseudouridine synthase activity
PAES_RS02260	COG0009	L-threonylcarbamoyladenylate synthase
PAES_RS02270	COG0248	Ppx GppA phosphatase
PAES_RS02275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PAES_RS02285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PAES_RS02295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PAES_RS02305	COG1196	nuclear chromosome segregation
PAES_RS02310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PAES_RS02330	COG1151	hydroxylamine reductase activity
PAES_RS02345	COG0640	Transcriptional regulator
PAES_RS02360	COG0546	phosphoglycolate phosphatase activity
PAES_RS02365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PAES_RS02390	COG0574	Belongs to the PEP-utilizing enzyme family
PAES_RS02390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PAES_RS02395	COG1079	Belongs to the binding-protein-dependent transport system permease family
PAES_RS02400	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PAES_RS02420	COG1663	tetraacyldisaccharide 4'-kinase activity
PAES_RS02430	COG0151	Belongs to the GarS family
PAES_RS02440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PAES_RS02445	COG0134	indole-3-glycerol-phosphate synthase activity
PAES_RS02450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PAES_RS02465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PAES_RS02465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PAES_RS02470	COG0077	Prephenate dehydratase
PAES_RS02470	COG1605	Chorismate mutase
PAES_RS02475	COG0217	transcriptional regulatory protein
PAES_RS02480	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PAES_RS02485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PAES_RS02490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PAES_RS02490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PAES_RS02500	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PAES_RS02515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PAES_RS02520	COG0495	leucyl-tRNA aminoacylation
PAES_RS02525	COG1185	polyribonucleotide nucleotidyltransferase activity
PAES_RS02530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PAES_RS02535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PAES_RS02540	COG4608	Belongs to the ABC transporter superfamily
PAES_RS02545	COG0616	signal peptide processing
PAES_RS02550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PAES_RS02550	COG3153	acetyltransferase
PAES_RS02555	COG0606	chelatase, subunit chli
PAES_RS02565	COG3245	cytochrome
PAES_RS02570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PAES_RS02575	COG2264	protein methyltransferase activity
PAES_RS02585	COG4974	Belongs to the 'phage' integrase family
PAES_RS02595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PAES_RS02605	COG0601	transmembrane transport
PAES_RS02610	COG2255	four-way junction helicase activity
PAES_RS02635	COG1959	2 iron, 2 sulfur cluster binding
PAES_RS02645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PAES_RS02645	COG1013	pyruvate-flavodoxin oxidoreductase activity
PAES_RS02645	COG0674	pyruvate-flavodoxin oxidoreductase activity
PAES_RS02645	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PAES_RS02650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PAES_RS02655	COG0509	glycine decarboxylation via glycine cleavage system
PAES_RS02660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PAES_RS02665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PAES_RS02670	COG0497	DNA recombination
PAES_RS02680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PAES_RS02685	COG0688	phosphatidylethanolamine metabolic process
PAES_RS02690	COG0037	tRNA processing
PAES_RS02700	COG0328	RNA-DNA hybrid ribonuclease activity
PAES_RS02705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PAES_RS02710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PAES_RS02715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PAES_RS02730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PAES_RS02740	COG4591	ABC-type transport system involved in lipoprotein release permease component
PAES_RS02745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PAES_RS02770	COG0716	FMN binding
PAES_RS02785	COG0848	biopolymer transport protein
PAES_RS02790	COG0811	peptide transport
PAES_RS02795	COG4771	TonB-dependent receptor
PAES_RS02810	COG4206	TonB-dependent receptor
PAES_RS02830	COG4771	TonB-dependent receptor
PAES_RS02835	COG0811	peptide transport
PAES_RS02845	COG0848	biopolymer transport protein
PAES_RS02870	COG1321	iron dependent repressor
PAES_RS02900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PAES_RS02905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PAES_RS02905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PAES_RS02910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PAES_RS02920	COG0358	DNA primase activity
PAES_RS02930	COG0811	peptide transport
PAES_RS02935	COG0848	biopolymer transport protein
PAES_RS02940	COG0848	biopolymer transport protein
PAES_RS02955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PAES_RS02975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PAES_RS02980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PAES_RS02985	COG0673	inositol 2-dehydrogenase activity
PAES_RS02990	COG2076	Multidrug Resistance protein
PAES_RS02995	COG0488	(ABC) transporter
PAES_RS03000	COG4221	oxidoreductase activity
PAES_RS03005	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PAES_RS03020	COG0189	ligase activity
PAES_RS03025	COG0045	succinate-CoA ligase (ADP-forming) activity
PAES_RS03030	COG0590	tRNA wobble adenosine to inosine editing
PAES_RS03040	COG2070	2-Nitropropane dioxygenase
PAES_RS03045	COG0588	phosphoglycerate mutase activity
PAES_RS03050	COG0070	glutamate synthase
PAES_RS03050	COG0069	glutamate synthase activity
PAES_RS03050	COG0067	glutamate synthase
PAES_RS03055	COG0493	'glutamate synthase
PAES_RS03065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PAES_RS03075	COG4974	Belongs to the 'phage' integrase family
PAES_RS03105	COG1116	anion transmembrane transporter activity
PAES_RS03110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PAES_RS03125	COG0455	bacterial-type flagellum organization
PAES_RS03145	COG3344	reverse transcriptase
PAES_RS03240	COG3344	reverse transcriptase
PAES_RS03310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PAES_RS03315	COG0557	exoribonuclease II activity
PAES_RS03320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PAES_RS03320	COG0475	glutathione-regulated potassium exporter activity
PAES_RS03335	COG0784	Response regulator, receiver
PAES_RS03335	COG2205	protein histidine kinase activity
PAES_RS03355	COG0133	tryptophan synthase activity
PAES_RS03375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PAES_RS03385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PAES_RS03390	COG0459	protein refolding
PAES_RS03395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PAES_RS03405	COG0159	tryptophan synthase activity
PAES_RS03430	COG2814	Major facilitator Superfamily
PAES_RS03435	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
PAES_RS03440	COG0438	transferase activity, transferring glycosyl groups
PAES_RS03445	COG1077	Cell shape determining protein MreB Mrl
PAES_RS03450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PAES_RS03455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PAES_RS03460	COG1049	propionate catabolic process, 2-methylcitrate cycle
PAES_RS03495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PAES_RS03510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PAES_RS03515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PAES_RS03525	COG0586	Pfam SNARE associated Golgi protein
PAES_RS03530	COG1945	arginine decarboxylase activity
PAES_RS03535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PAES_RS03540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PAES_RS03545	COG0277	FAD linked oxidase domain protein
PAES_RS03550	COG0768	penicillin binding
PAES_RS03560	COG1792	Involved in formation and maintenance of cell shape
PAES_RS03570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PAES_RS03575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PAES_RS03590	COG2884	Cell division ATP-binding protein ftsE
PAES_RS03595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PAES_RS03605	COG1519	Transferase
PAES_RS03640	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PAES_RS03645	COG4974	Belongs to the 'phage' integrase family
PAES_RS03650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PAES_RS03650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PAES_RS03655	COG2873	o-acetylhomoserine
PAES_RS03660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PAES_RS03665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PAES_RS03670	COG1610	YqeY-like protein
PAES_RS03675	COG4221	oxidoreductase activity
PAES_RS03680	COG1278	Cold shock
PAES_RS03685	COG2003	Belongs to the UPF0758 family
PAES_RS03690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PAES_RS03695	COG0066	3-isopropylmalate dehydratase activity
PAES_RS03700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PAES_RS03705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PAES_RS03710	COG0473	3-isopropylmalate dehydrogenase activity
PAES_RS03715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PAES_RS03720	COG0440	acetolactate synthase activity
PAES_RS03725	COG0028	Belongs to the TPP enzyme family
PAES_RS03730	COG0129	dihydroxy-acid dehydratase activity
PAES_RS03740	COG1836	PFAM Integral membrane protein DUF92
PAES_RS03750	COG0848	biopolymer transport protein
PAES_RS03760	COG0823	Involved in the tonB-independent uptake of proteins
PAES_RS03765	COG2885	chlorophyll binding
PAES_RS03770	COG2885	chlorophyll binding
PAES_RS03785	COG0443	Heat shock 70 kDa protein
PAES_RS03790	COG0071	Belongs to the small heat shock protein (HSP20) family
PAES_RS03805	COG1595	DNA-templated transcription, initiation
PAES_RS03825	COG0633	Ferredoxin
PAES_RS03830	COG0633	Ferredoxin
PAES_RS03835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PAES_RS03840	COG0444	Belongs to the ABC transporter superfamily
PAES_RS03845	COG0745	RESPONSE REGULATOR receiver
PAES_RS03850	COG5002	protein histidine kinase activity
PAES_RS03855	COG0668	transmembrane transport
PAES_RS03875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PAES_RS03880	COG1678	Uncharacterized ACR, COG1678
PAES_RS03915	COG2274	protein secretion by the type I secretion system
PAES_RS03925	COG0494	nUDIX hydrolase
PAES_RS03955	COG1566	PFAM secretion protein HlyD family protein
PAES_RS03975	COG0668	transmembrane transport
PAES_RS04015	COG0135	phosphoribosylanthranilate isomerase activity
PAES_RS04025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PAES_RS04030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PAES_RS04035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PAES_RS04055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PAES_RS04090	COG0072	phenylalanine-tRNA ligase activity
PAES_RS04090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PAES_RS04105	COG1418	mRNA catabolic process
PAES_RS04110	COG0131	Imidazoleglycerol-phosphate dehydratase
PAES_RS04140	COG1607	acyl-coa hydrolase
PAES_RS04155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PAES_RS04155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PAES_RS04165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PAES_RS04170	COG0307	riboflavin synthase, alpha
PAES_RS04175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PAES_RS04190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PAES_RS04190	COG4651	solute:proton antiporter activity
PAES_RS04235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAES_RS04240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAES_RS04245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAES_RS04250	COG0649	NAD binding
PAES_RS04255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PAES_RS04260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PAES_RS04270	COG0713	ATP synthesis coupled electron transport
PAES_RS04275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PAES_RS04285	COG1007	ATP synthesis coupled electron transport
PAES_RS04290	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
PAES_RS04300	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
PAES_RS04310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PAES_RS04320	COG0302	gtp cyclohydrolase
PAES_RS04330	COG3118	belongs to the thioredoxin family
PAES_RS04375	COG1030	water channel activity
PAES_RS04380	COG0330	HflC and HflK could
PAES_RS04385	COG0589	response to stress
PAES_RS04390	COG1703	isobutyryl-CoA mutase activity
PAES_RS04395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PAES_RS04395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PAES_RS04400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PAES_RS04405	COG0346	lactoylglutathione lyase activity
PAES_RS04420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PAES_RS04425	COG3958	Transketolase
PAES_RS04430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PAES_RS04435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PAES_RS04440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PAES_RS04440	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PAES_RS04470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PAES_RS04490	COG0356	it plays a direct role in the translocation of protons across the membrane
PAES_RS04500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PAES_RS04505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PAES_RS04510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PAES_RS04525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PAES_RS04530	COG0667	Aldo Keto reductase
PAES_RS04535	COG0659	secondary active sulfate transmembrane transporter activity
PAES_RS04540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PAES_RS04560	COG2326	polyphosphate kinase activity
PAES_RS04575	COG0157	Belongs to the NadC ModD family
PAES_RS04580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PAES_RS04585	COG2089	acid synthase
PAES_RS04590	COG0326	Molecular chaperone. Has ATPase activity
PAES_RS04610	COG0589	response to stress
PAES_RS04635	COG1554	hydrolase, family 65, central catalytic
PAES_RS04640	COG0438	transferase activity, transferring glycosyl groups
PAES_RS04650	COG3118	belongs to the thioredoxin family
PAES_RS04660	COG0494	nUDIX hydrolase
PAES_RS04665	COG2204	response regulator
PAES_RS04685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PAES_RS04725	COG0546	phosphoglycolate phosphatase activity
PAES_RS04730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PAES_RS04755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PAES_RS04760	COG0573	inorganic phosphate transmembrane transporter activity
PAES_RS04765	COG0581	inorganic phosphate transmembrane transporter activity
PAES_RS04770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PAES_RS04775	COG0704	Plays a role in the regulation of phosphate uptake
PAES_RS04800	COG1216	Glycosyl transferase, family 2
PAES_RS04810	COG0277	FAD linked oxidase domain protein
PAES_RS04825	COG0436	Aminotransferase
PAES_RS04830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PAES_RS04830	COG1796	DNA polymerase
PAES_RS04925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PAES_RS04950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PAES_RS04955	COG0501	Belongs to the peptidase M48B family
PAES_RS04960	COG2176	DNA-directed DNA polymerase activity
PAES_RS04995	COG1858	cytochrome C peroxidase
PAES_RS05000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PAES_RS05000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PAES_RS05005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PAES_RS05010	COG0653	protein targeting
PAES_RS05015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PAES_RS05020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PAES_RS05035	COG1301	dicarboxylic acid transport
PAES_RS05050	COG0352	thiamine-phosphate diphosphorylase activity
PAES_RS05055	COG0352	thiamine-phosphate diphosphorylase activity
PAES_RS05060	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
PAES_RS05075	COG0793	Belongs to the peptidase S41A family
PAES_RS05075	COG3409	Peptidoglycan-binding domain 1 protein
PAES_RS05090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PAES_RS05090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PAES_RS05095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PAES_RS05100	COG0228	four-way junction DNA binding
PAES_RS05105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PAES_RS05110	COG0336	Belongs to the RNA methyltransferase TrmD family
PAES_RS05115	COG0335	large ribosomal subunit rRNA binding
PAES_RS05120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PAES_RS05125	COG1194	a g-specific adenine glycosylase
PAES_RS05130	COG1022	Amp-dependent synthetase and ligase
PAES_RS05145	COG1083	cytidylyl-transferase
PAES_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
PAES_RS05150	COG1454	alcohol dehydrogenase
PAES_RS05155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PAES_RS05170	COG1192	Involved in chromosome partitioning
PAES_RS05185	COG1744	ABC transporter substrate-binding protein PnrA-like
PAES_RS05195	COG1088	dTDP-glucose 4,6-dehydratase activity
PAES_RS05200	COG0517	IMP dehydrogenase activity
PAES_RS05205	COG2176	DNA-directed DNA polymerase activity
PAES_RS05220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PAES_RS05225	COG0179	Fumarylacetoacetate (FAA) hydrolase
PAES_RS05230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PAES_RS05235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PAES_RS05240	COG0698	ribose 5-phosphate isomerase
PAES_RS05250	COG1473	amidohydrolase
PAES_RS05255	COG0191	fructose-bisphosphate aldolase activity
PAES_RS05265	COG0165	Argininosuccinate lyase
PAES_RS05275	COG0659	secondary active sulfate transmembrane transporter activity
PAES_RS05280	COG0589	response to stress
PAES_RS05290	COG0318	PFAM AMP-dependent synthetase and ligase
PAES_RS05345	COG2308	Evidence 4 Homologs of previously reported genes of
PAES_RS05355	COG1305	Transglutaminase-like
PAES_RS05370	COG0205	6-phosphofructokinase activity
PAES_RS05380	COG3588	fructose-bisphosphate aldolase
PAES_RS05385	COG0137	argininosuccinate synthase activity
PAES_RS05390	COG1438	arginine binding
PAES_RS05395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PAES_RS05400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PAES_RS05405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PAES_RS05410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PAES_RS05425	COG4591	ABC-type transport system involved in lipoprotein release permease component
PAES_RS05435	COG1773	rubredoxin
PAES_RS05450	COG2119	membrane
PAES_RS05460	COG4619	ABC transporter
PAES_RS05465	COG0390	transport system, permease component
PAES_RS05470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PAES_RS05475	COG0045	succinate-CoA ligase (ADP-forming) activity
PAES_RS05480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PAES_RS05490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PAES_RS05545	COG0842	Transport permease protein
PAES_RS05550	COG0842	Transport permease protein
PAES_RS05555	COG1131	(ABC) transporter
PAES_RS05560	COG1131	(ABC) transporter
PAES_RS05565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PAES_RS05570	COG1077	Cell shape determining protein MreB Mrl
PAES_RS05580	COG3409	Peptidoglycan-binding domain 1 protein
PAES_RS05580	COG3773	Cell wall hydrolase
PAES_RS05600	COG0701	Predicted permease
PAES_RS05605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PAES_RS05610	COG0798	PFAM Bile acid sodium symporter
PAES_RS05640	COG1151	hydroxylamine reductase activity
PAES_RS05715	COG0668	transmembrane transport
PAES_RS05720	COG0640	Transcriptional regulator
PAES_RS05725	COG0577	efflux transmembrane transporter activity
PAES_RS05725	COG1136	(ABC) transporter
PAES_RS05755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PAES_RS05775	COG1028	Short-chain dehydrogenase reductase Sdr
PAES_RS05780	COG0633	Ferredoxin
PAES_RS05790	COG3318	Belongs to the UPF0149 family
PAES_RS05800	COG0419	ATPase involved in DNA repair
PAES_RS05810	COG1074	ATP-dependent DNA helicase activity
PAES_RS05825	COG1509	lysine 2,3-aminomutase activity
PAES_RS05840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PAES_RS05850	COG0563	adenylate kinase activity
PAES_RS05855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PAES_RS05870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PAES_RS05875	COG0670	Belongs to the BI1 family
PAES_RS05880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PAES_RS05885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PAES_RS05890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PAES_RS05900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PAES_RS05905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PAES_RS05910	COG1950	PFAM Membrane protein of
PAES_RS05915	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PAES_RS05920	COG3845	ABC transporter
PAES_RS05925	COG4603	Belongs to the binding-protein-dependent transport system permease family
PAES_RS05930	COG0038	chloride channel
PAES_RS05945	COG0142	geranyltranstransferase activity
PAES_RS05960	COG0805	protein transport
PAES_RS05970	COG0237	dephospho-CoA kinase activity
PAES_RS05980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PAES_RS05990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PAES_RS05995	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
PAES_RS06000	COG3118	belongs to the thioredoxin family
PAES_RS06005	COG0396	ATPase activity
PAES_RS06050	COG2081	HI0933 family
PAES_RS06065	COG1136	(ABC) transporter
PAES_RS06080	COG0415	Belongs to the DNA photolyase family
PAES_RS06120	COG2195	Cleaves the N-terminal amino acid of tripeptides
PAES_RS06175	COG0702	epimerase
PAES_RS06195	COG0724	RNA recognition motif
PAES_RS06210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PAES_RS06260	COG1342	Belongs to the UPF0251 family
PAES_RS06275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PAES_RS06280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PAES_RS06285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PAES_RS06345	COG0604	alcohol dehydrogenase
PAES_RS06350	COG1120	ATPase activity
PAES_RS06355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAES_RS06360	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PAES_RS06365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PAES_RS06370	COG1492	cobalamin metabolic process
PAES_RS06375	COG0778	Nitroreductase
PAES_RS06380	COG4206	TonB-dependent receptor
PAES_RS06385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PAES_RS06390	COG4206	TonB-dependent receptor
PAES_RS06400	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PAES_RS06430	COG4771	TonB-dependent receptor
PAES_RS06435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PAES_RS06440	COG1120	ATPase activity
PAES_RS06445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PAES_RS06470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PAES_RS06470	COG1648	precorrin-2 dehydrogenase activity
PAES_RS06480	COG1648	precorrin-2 dehydrogenase activity
PAES_RS06480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PAES_RS06500	COG1120	ATPase activity
PAES_RS06520	COG4771	TonB-dependent receptor
PAES_RS06530	COG0494	nUDIX hydrolase
PAES_RS06535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PAES_RS06545	COG0617	tRNA 3'-terminal CCA addition
PAES_RS06550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PAES_RS06560	COG2878	Part of a membrane complex involved in electron transport
PAES_RS06560	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
PAES_RS06565	COG4656	Part of a membrane complex involved in electron transport
PAES_RS06570	COG4658	electron transport chain
PAES_RS06580	COG4660	Part of a membrane complex involved in electron transport
PAES_RS06585	COG4657	Part of a membrane complex involved in electron transport
PAES_RS06610	COG0428	transporter
PAES_RS06615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PAES_RS06620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PAES_RS06625	COG0443	Heat shock 70 kDa protein
PAES_RS06650	COG2133	pyrroloquinoline quinone binding
PAES_RS06660	COG2963	transposase activity
PAES_RS06705	COG0166	Belongs to the GPI family
PAES_RS06715	COG0004	ammonium transporteR
PAES_RS06720	COG0347	Belongs to the P(II) protein family
PAES_RS06730	COG0864	Transcriptional regulator
PAES_RS06740	COG0310	cobalt ion transport
PAES_RS06755	COG1122	ATPase activity
PAES_RS06770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PAES_RS06775	COG0003	Pfam Anion-transporting ATPase
PAES_RS06785	COG0101	tRNA pseudouridine synthase activity
PAES_RS06790	COG0366	Alpha amylase catalytic
PAES_RS06800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PAES_RS06805	COG0424	maF-like protein
PAES_RS06825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PAES_RS06830	COG3876	Protein conserved in bacteria
PAES_RS06850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PAES_RS06850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PAES_RS06855	COG1774	PSP1 C-terminal conserved region
PAES_RS06865	COG0436	Aminotransferase
PAES_RS06870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PAES_RS06875	COG0742	ribosomal rna small subunit methyltransferase
PAES_RS06880	COG3959	Transketolase, thiamine diphosphate binding domain
PAES_RS06890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PAES_RS06905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PAES_RS06910	COG0193	aminoacyl-tRNA hydrolase activity
PAES_RS06915	COG0596	Alpha beta hydrolase
PAES_RS06920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PAES_RS06925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PAES_RS06940	COG1702	phosphate starvation-inducible protein PhoH
PAES_RS06965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PAES_RS06970	COG0463	Glycosyl transferase, family 2
PAES_RS06970	COG1216	Glycosyl transferase, family 2
PAES_RS06980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PAES_RS06985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PAES_RS06985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PAES_RS06990	COG1331	Highly conserved protein containing a thioredoxin domain
PAES_RS07005	COG1538	Outer membrane efflux protein
PAES_RS07015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PAES_RS07065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PAES_RS07070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PAES_RS07075	COG1518	maintenance of DNA repeat elements
PAES_RS07085	COG1857	crispr-associated protein
PAES_RS07110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PAES_RS07125	COG1032	radical SAM domain protein
PAES_RS07150	COG0516	GMP reductase activity
PAES_RS07170	COG2602	Beta-lactamase
PAES_RS07175	COG1429	ligase activity, forming nitrogen-metal bonds
PAES_RS07180	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PAES_RS07180	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PAES_RS07185	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PAES_RS07190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PAES_RS07195	COG0564	pseudouridine synthase activity
PAES_RS07215	COG1505	serine-type exopeptidase activity
PAES_RS07230	COG0488	(ABC) transporter
PAES_RS07245	COG1943	Transposase
PAES_RS07255	COG1943	Transposase
PAES_RS07260	COG1013	pyruvate-flavodoxin oxidoreductase activity
PAES_RS07275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PAES_RS07290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PAES_RS07305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PAES_RS07310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PAES_RS07325	COG2050	protein possibly involved in aromatic compounds catabolism
PAES_RS07330	COG1032	radical SAM domain protein
PAES_RS07345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PAES_RS07350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PAES_RS07355	COG1295	ribonuclease BN
PAES_RS07360	COG2270	Major facilitator Superfamily
PAES_RS07365	COG0047	phosphoribosylformylglycinamidine synthase activity
PAES_RS07370	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PAES_RS07380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PAES_RS07385	COG0095	Lipoate-protein ligase
PAES_RS07395	COG1832	CoA-binding protein
PAES_RS07400	COG1181	Belongs to the D-alanine--D-alanine ligase family
PAES_RS07420	COG1136	(ABC) transporter
PAES_RS07425	COG0577	efflux transmembrane transporter activity
PAES_RS07425	COG1136	(ABC) transporter
PAES_RS07430	COG0577	efflux transmembrane transporter activity
PAES_RS07430	COG1136	(ABC) transporter
PAES_RS07450	COG3387	PFAM Glycoside hydrolase 15-related
PAES_RS07455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PAES_RS07460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PAES_RS07465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PAES_RS07470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PAES_RS07485	COG2333	competence protein COMEC
PAES_RS07485	COG0658	competence protein
PAES_RS07490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PAES_RS07495	COG0019	diaminopimelate decarboxylase activity
PAES_RS07500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PAES_RS07515	COG0436	Aminotransferase
PAES_RS07530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PAES_RS07535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PAES_RS07540	COG1562	ergosterol biosynthetic process
PAES_RS07545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PAES_RS07565	COG0343	queuine tRNA-ribosyltransferase activity
PAES_RS07570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PAES_RS07575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PAES_RS07580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PAES_RS07585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PAES_RS07590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PAES_RS07600	COG0432	Pfam Uncharacterised protein family UPF0047
PAES_RS07620	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PAES_RS07620	COG0493	'glutamate synthase
PAES_RS07640	COG2204	response regulator
PAES_RS07645	COG0756	dUTP diphosphatase activity
PAES_RS07655	COG0492	ferredoxin-NADP+ reductase activity
PAES_RS07670	COG1063	alcohol dehydrogenase
PAES_RS07675	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PAES_RS07680	COG1217	gtp-binding protein TYPA
PAES_RS07690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PAES_RS07695	COG0181	hydroxymethylbilane synthase activity
PAES_RS07700	COG1587	Uroporphyrinogen-III synthase
PAES_RS07705	COG1322	Protein conserved in bacteria
PAES_RS07720	COG0590	tRNA wobble adenosine to inosine editing
PAES_RS07730	COG0113	porphobilinogen synthase activity
PAES_RS07735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PAES_RS07775	COG0513	Belongs to the DEAD box helicase family
PAES_RS07790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PAES_RS07790	COG0731	radical SAM domain protein
PAES_RS07805	COG0149	triose-phosphate isomerase activity
PAES_RS07815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PAES_RS07840	COG0481	GTPase activity
PAES_RS07845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PAES_RS07850	COG0242	peptide deformylase activity
PAES_RS07870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PAES_RS07875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PAES_RS07880	COG1136	(ABC) transporter
PAES_RS07885	COG2211	Major facilitator Superfamily
PAES_RS07890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PAES_RS07900	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PAES_RS07905	COG0484	heat shock protein binding
PAES_RS07910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PAES_RS07915	COG1420	regulation of RNA biosynthetic process
PAES_RS07920	COG2890	protein-(glutamine-N5) methyltransferase activity
PAES_RS07930	COG0442	prolyl-tRNA aminoacylation
PAES_RS07935	COG0450	alkyl hydroperoxide reductase
PAES_RS07940	COG2252	PERMEase
PAES_RS07945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PAES_RS07950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PAES_RS07965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PAES_RS07975	COG4978	Transcriptional regulator
PAES_RS07975	COG0789	Transcriptional regulator
PAES_RS07980	COG1132	(ABC) transporter
PAES_RS07985	COG1032	radical SAM domain protein
PAES_RS07990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PAES_RS08000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PAES_RS08005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PAES_RS08010	COG0039	L-malate dehydrogenase activity
PAES_RS08030	COG1283	sodium-dependent phosphate transmembrane transporter activity
PAES_RS08040	COG1575	Belongs to the MenA family. Type 1 subfamily
PAES_RS08045	COG0492	ferredoxin-NADP+ reductase activity
PAES_RS08055	COG0107	imidazoleglycerol-phosphate synthase activity
PAES_RS08080	COG0598	Magnesium transport protein CorA
PAES_RS08095	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PAES_RS08110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PAES_RS08115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PAES_RS08125	COG1970	mechanosensitive ion channel activity
PAES_RS08130	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PAES_RS08135	COG0347	Belongs to the P(II) protein family
PAES_RS08140	COG0347	Belongs to the P(II) protein family
PAES_RS08165	COG1433	Dinitrogenase iron-molybdenum cofactor
PAES_RS08165	COG0535	radical SAM domain protein
PAES_RS08180	COG4149	molybdate abc transporter
PAES_RS08205	COG0298	carbon dioxide binding
PAES_RS08210	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PAES_RS08220	COG0375	protein maturation
PAES_RS08225	COG0540	Belongs to the ATCase OTCase family
PAES_RS08250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PAES_RS08255	COG0322	excinuclease ABC activity
PAES_RS08265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PAES_RS08270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PAES_RS08275	COG0084	hydrolase, TatD family'
PAES_RS08300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PAES_RS08305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PAES_RS08310	COG1271	oxidase subunit
PAES_RS08315	COG1294	oxidase, subunit
PAES_RS08320	COG4988	ABC transporter
PAES_RS08325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PAES_RS08330	COG3040	lipid binding
PAES_RS08335	COG0788	formyltetrahydrofolate deformylase activity
PAES_RS08345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PAES_RS08350	COG0463	Glycosyl transferase, family 2
PAES_RS08360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PAES_RS08360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PAES_RS08365	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PAES_RS08370	COG1692	metallophosphoesterase
PAES_RS08375	COG1741	Belongs to the pirin family
PAES_RS08385	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PAES_RS08390	COG0003	Pfam Anion-transporting ATPase
PAES_RS08395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PAES_RS08410	COG2154	pterin-4-alpha-carbinolamine dehydratase
PAES_RS08425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PAES_RS08435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PAES_RS08440	COG1193	negative regulation of DNA recombination
PAES_RS08445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PAES_RS08450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PAES_RS08455	COG1968	undecaprenyl-diphosphatase activity
PAES_RS08460	COG0613	PHP domain protein
PAES_RS08465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PAES_RS08470	COG1127	ABC transporter
PAES_RS08480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PAES_RS08485	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PAES_RS08490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PAES_RS08495	COG0138	bifunctional purine biosynthesis protein purh
PAES_RS08500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PAES_RS08505	COG0602	queuosine metabolic process
PAES_RS08510	COG0463	Glycosyl transferase, family 2
PAES_RS08515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PAES_RS08520	COG2177	Part of the ABC transporter FtsEX involved in
PAES_RS08535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PAES_RS08545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PAES_RS08570	COG3846	protein secretion by the type IV secretion system
PAES_RS08585	COG3451	type IV secretory pathway VirB4
PAES_RS08595	COG3838	Conjugal transfer protein Trbc
PAES_RS08600	COG4962	Type ii secretion system protein e
PAES_RS08620	COG1091	dTDP-4-dehydrorhamnose reductase activity
PAES_RS08690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PAES_RS08725	COG0529	Catalyzes the synthesis of activated sulfate
PAES_RS08730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PAES_RS08735	COG0471	metal ion transport
PAES_RS08735	COG3273	potassium ion transport
PAES_RS08745	COG2895	sulfate adenylyltransferase (ATP) activity
PAES_RS08745	COG0529	Catalyzes the synthesis of activated sulfate
PAES_RS08750	COG0175	sulfate reduction
PAES_RS08770	COG0529	Catalyzes the synthesis of activated sulfate
PAES_RS08770	COG2895	sulfate adenylyltransferase (ATP) activity
PAES_RS08775	COG0175	sulfate reduction
PAES_RS08790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PAES_RS08830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PAES_RS08855	COG3206	protein involved in exopolysaccharide biosynthesis
PAES_RS08855	COG0489	protein tyrosine kinase activity
PAES_RS08875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PAES_RS08900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PAES_RS08905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PAES_RS08910	COG0730	response to heat
PAES_RS08930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PAES_RS08935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PAES_RS08945	COG0772	Belongs to the SEDS family
PAES_RS08950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PAES_RS08955	COG0539	negative regulation of cytoplasmic translation
PAES_RS08960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PAES_RS08965	COG0012	GTP binding
PAES_RS08970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PAES_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
PAES_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
PAES_RS08990	COG1850	ribulose-bisphosphate carboxylase activity
PAES_RS08995	COG1830	Aldolase
PAES_RS09000	COG3347	Dehydrogenase
PAES_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
PAES_RS09015	COG1032	radical SAM domain protein
PAES_RS09020	COG2137	regulation of response to DNA damage stimulus
PAES_RS09025	COG0528	UMP kinase activity
PAES_RS09030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PAES_RS09035	COG0052	Belongs to the universal ribosomal protein uS2 family
PAES_RS09040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PAES_RS09045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PAES_RS09050	COG1160	GTP binding
PAES_RS09055	COG0489	protein tyrosine kinase activity
PAES_RS09060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PAES_RS09065	COG1674	ftsk spoiiie
PAES_RS09070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PAES_RS09095	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PAES_RS09100	COG1704	LemA family
PAES_RS09110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PAES_RS09115	COG0556	nucleotide-excision repair
PAES_RS09125	COG0612	Peptidase, M16
PAES_RS09140	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
PAES_RS09145	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PAES_RS09150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PAES_RS09155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PAES_RS09160	COG0525	valine-tRNA ligase activity
PAES_RS09165	COG0740	serine-type endopeptidase activity
PAES_RS09170	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PAES_RS09175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PAES_RS09180	COG1752	Esterase of the alpha-beta hydrolase superfamily
PAES_RS09185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PAES_RS09190	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PAES_RS09200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PAES_RS09215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PAES_RS09225	COG1611	Belongs to the LOG family
PAES_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
PAES_RS09275	COG1162	GTPase activity
PAES_RS09280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PAES_RS09285	COG0254	rRNA binding
PAES_RS09290	COG0233	cytoplasmic translational termination
PAES_RS09295	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PAES_RS09305	COG1570	exodeoxyribonuclease VII activity
PAES_RS09310	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PAES_RS09315	COG1490	D-aminoacyl-tRNA deacylase activity
PAES_RS09320	COG1872	DUF167
PAES_RS09325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PAES_RS09330	COG0372	Belongs to the citrate synthase family
PAES_RS09335	COG1115	amino acid carrier protein
PAES_RS09365	COG1169	isochorismate synthase
PAES_RS09370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PAES_RS09375	COG0596	Alpha beta hydrolase
PAES_RS09385	COG1441	menaquinone biosynthetic process
PAES_RS09390	COG0318	PFAM AMP-dependent synthetase and ligase
PAES_RS09395	COG1902	pentaerythritol trinitrate reductase activity
PAES_RS09415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PAES_RS09420	COG1475	DNA binding
PAES_RS09425	COG1192	Involved in chromosome partitioning
PAES_RS09430	COG2094	Belongs to the DNA glycosylase MPG family
PAES_RS09435	COG2239	Acts as a magnesium transporter
PAES_RS09440	COG0644	oxidoreductase
PAES_RS09440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PAES_RS09445	COG0482	sulfurtransferase activity
PAES_RS09450	COG0400	carboxylic ester hydrolase activity
PAES_RS09455	COG1410	methionine synthase
PAES_RS09455	COG0646	methionine synthase
PAES_RS09460	COG2989	Protein conserved in bacteria
PAES_RS09500	COG1196	nuclear chromosome segregation
PAES_RS09500	COG3264	Mechanosensitive ion channel
PAES_RS09510	COG0363	glucosamine-6-phosphate deaminase activity
PAES_RS09515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PAES_RS09520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PAES_RS09570	COG1752	Esterase of the alpha-beta hydrolase superfamily
PAES_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
PAES_RS09580	COG0861	Integral membrane protein TerC family
PAES_RS09585	COG1067	ATP-dependent peptidase activity
PAES_RS09600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PAES_RS09610	COG0826	peptidase U32
PAES_RS09630	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PAES_RS09640	COG1047	Peptidyl-prolyl cis-trans
PAES_RS09670	COG1032	radical SAM domain protein
PAES_RS09675	COG1078	dGTPase activity
PAES_RS09685	COG2267	carboxylic ester hydrolase activity
PAES_RS09690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PAES_RS09695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PAES_RS09710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PAES_RS09725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PAES_RS09730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PAES_RS09735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PAES_RS09740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PAES_RS09745	COG0612	Peptidase, M16
PAES_RS09750	COG0544	peptidyl-prolyl cis-trans isomerase activity
PAES_RS09765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PAES_RS09795	COG0543	2 iron, 2 sulfur cluster binding
PAES_RS09800	COG0629	single-stranded DNA binding
PAES_RS09815	COG0156	8-amino-7-oxononanoate synthase activity
PAES_RS09820	COG4206	TonB-dependent receptor
PAES_RS09825	COG1429	ligase activity, forming nitrogen-metal bonds
PAES_RS09830	COG1077	Cell shape determining protein MreB Mrl
PAES_RS09850	COG1429	ligase activity, forming nitrogen-metal bonds
PAES_RS09855	COG2226	methyltransferase
PAES_RS09865	COG0071	Belongs to the small heat shock protein (HSP20) family
PAES_RS09875	COG3174	membrane
PAES_RS09930	COG1337	RAMP superfamily
PAES_RS09955	COG1216	Glycosyl transferase, family 2
PAES_RS09960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PAES_RS09965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PAES_RS09975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PAES_RS09980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PAES_RS09990	COG1104	cysteine desulfurase activity
PAES_RS10015	COG1253	flavin adenine dinucleotide binding
PAES_RS10020	COG0105	UTP biosynthetic process
PAES_RS10025	COG1686	Belongs to the peptidase S11 family
PAES_RS10035	COG0628	permease
PAES_RS10040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PAES_RS10045	COG1040	competence protein
PAES_RS10050	COG1940	carbohydrate kinase activity
PAES_RS10055	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PAES_RS10065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PAES_RS10070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PAES_RS10075	COG0297	glycogen (starch) synthase activity
PAES_RS10110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PAES_RS10115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PAES_RS10120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PAES_RS10130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PAES_RS10135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PAES_RS10140	COG0215	cysteine-tRNA ligase activity
PAES_RS10150	COG0357	Ribosomal RNA small subunit methyltransferase G
PAES_RS10155	COG0203	ribosomal protein L17
PAES_RS10160	COG0202	RNA polymerase activity
PAES_RS10165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PAES_RS10170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PAES_RS10175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PAES_RS10180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PAES_RS10195	COG0200	Binds to the 23S rRNA
PAES_RS10200	COG1841	ribosomal large subunit assembly
PAES_RS10205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PAES_RS10210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PAES_RS10215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PAES_RS10220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PAES_RS10225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PAES_RS10230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PAES_RS10235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PAES_RS10245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PAES_RS10250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PAES_RS10255	COG0255	Belongs to the universal ribosomal protein uL29 family
PAES_RS10260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PAES_RS10265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PAES_RS10270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PAES_RS10275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PAES_RS10280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PAES_RS10285	COG0089	rRNA binding
PAES_RS10290	COG0088	Forms part of the polypeptide exit tunnel
PAES_RS10295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PAES_RS10300	COG0051	transcription antitermination factor activity, RNA binding
PAES_RS10305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PAES_RS10310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PAES_RS10315	COG0049	tRNA binding
PAES_RS10320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PAES_RS10350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PAES_RS10355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PAES_RS10360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PAES_RS10365	COG1722	exodeoxyribonuclease VII activity
PAES_RS10370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PAES_RS10380	COG0542	response to heat
PAES_RS10385	COG0069	glutamate synthase activity
PAES_RS10395	COG2304	oxidoreductase activity
PAES_RS10415	COG0714	Associated with various cellular activities
PAES_RS10425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PAES_RS10430	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PAES_RS10470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PAES_RS10515	COG1862	Preprotein translocase
PAES_RS10520	COG0505	Belongs to the CarA family
PAES_RS10535	COG1032	radical SAM domain protein
PAES_RS10560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PAES_RS10570	COG0314	molybdopterin synthase activity
PAES_RS10585	COG0521	Mo-molybdopterin cofactor biosynthetic process
PAES_RS10585	COG0315	cyclic pyranopterin monophosphate synthase activity
PAES_RS10590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PAES_RS10595	COG0584	glycerophosphoryl diester phosphodiesterase
PAES_RS10615	COG0746	molybdenum cofactor guanylyltransferase activity
PAES_RS10625	COG2871	sodium ion transport
PAES_RS10630	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PAES_RS10635	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PAES_RS10655	COG0243	molybdopterin cofactor binding
PAES_RS10660	COG0437	4 iron, 4 sulfur cluster binding
PAES_RS10665	COG3301	Polysulphide reductase, NrfD
PAES_RS10760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PAES_RS10765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PAES_RS10775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PAES_RS10795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PAES_RS10800	COG0542	response to heat
PAES_RS10810	COG1472	Belongs to the glycosyl hydrolase 3 family
PAES_RS10820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PAES_RS10825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PAES_RS10830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PAES_RS10835	COG0527	aspartate kinase activity
PAES_RS10845	COG2264	protein methyltransferase activity
PAES_RS10850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PAES_RS10850	COG0248	Ppx GppA phosphatase
PAES_RS10880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PAES_RS10885	COG4106	trans-aconitate 2-methyltransferase activity
PAES_RS10895	COG0156	8-amino-7-oxononanoate synthase activity
PAES_RS10900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PAES_RS10905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PAES_RS10905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PAES_RS10920	COG0450	alkyl hydroperoxide reductase
PAES_RS10930	COG1592	Rubrerythrin
PAES_RS10995	COG0860	N-Acetylmuramoyl-L-alanine amidase
PAES_RS11000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PAES_RS11005	COG1918	ferrous iron import across plasma membrane
PAES_RS11005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PAES_RS11010	COG1918	ferrous iron import across plasma membrane
PAES_RS11015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PAES_RS11020	COG0537	adenosine 5'-monophosphoramidase activity
PAES_RS11030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PAES_RS11065	COG1785	Belongs to the alkaline phosphatase family
PAES_RS11075	COG0596	Alpha beta hydrolase
PAES_RS11075	COG0508	dehydrogenase complex catalyzes the overall conversion of
PAES_RS11090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PAES_RS11110	COG0515	serine threonine protein kinase
PAES_RS11110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PAES_RS11115	COG1899	peptidyl-lysine modification to peptidyl-hypusine
PAES_RS11120	COG0180	Tryptophanyl-tRNA synthetase
PAES_RS11125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PAES_RS11130	COG0018	arginyl-trna synthetase
PAES_RS11135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PAES_RS11160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PAES_RS11165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PAES_RS11170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PAES_RS11175	COG0356	it plays a direct role in the translocation of protons across the membrane
PAES_RS11195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PAES_RS11200	COG1496	oxidoreductase activity
PAES_RS11210	COG2813	Specifically methylates the guanine in position
PAES_RS11215	COG0427	acetyl-CoA hydrolase
PAES_RS11220	COG1053	succinate dehydrogenase
PAES_RS11235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PAES_RS11250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PAES_RS11255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PAES_RS11260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PAES_RS11265	COG0772	Belongs to the SEDS family
PAES_RS11270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PAES_RS11275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PAES_RS11280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PAES_RS11285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PAES_RS11300	COG0275	rRNA processing
PAES_RS11305	COG2001	Belongs to the MraZ family
PAES_RS11320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PAES_RS11325	COG0126	phosphoglycerate kinase activity
PAES_RS11330	COG0457	Tetratricopeptide repeat
PAES_RS11330	COG0705	Rhomboid family
PAES_RS11345	COG1404	Belongs to the peptidase S8 family
PAES_RS11350	COG0024	Methionine aminopeptidase
PAES_RS11365	COG0641	radical SAM
PAES_RS11405	COG3011	Protein conserved in bacteria
PAES_RS11465	COG2963	transposase activity
PAES_RS11470	COG2801	Transposase and inactivated derivatives
PAES_RS11480	COG2963	transposase activity
PAES_RS11485	COG2801	Transposase and inactivated derivatives
PAES_RS11510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PAES_RS11545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PAES_RS11565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PAES_RS11570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PAES_RS11580	COG0671	phosphoesterase, PA-phosphatase related
PAES_RS11585	COG0706	membrane insertase activity
PAES_RS11590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PAES_RS11595	COG0594	ribonuclease P activity
PAES_RS11600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PAES_RS11610	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PAES_RS11930	COG1752	Esterase of the alpha-beta hydrolase superfamily
PAES_RS11965	COG1216	Glycosyl transferase, family 2
PAES_RS12015	COG0582	viral genome integration into host DNA
PAES_RS12050	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PAES_RS12065	COG0741	lytic transglycosylase activity
PAES_RS12065	COG1388	LysM domain
PAES_RS12075	COG5002	protein histidine kinase activity
PAES_RS12095	COG2948	multi-organism process
PAES_RS12115	COG2205	protein histidine kinase activity
PAES_RS12115	COG5002	protein histidine kinase activity
PAES_RS12115	COG0784	Response regulator, receiver
PAES_RS12135	COG0791	NLP P60 protein
PAES_RS12140	COG1785	Belongs to the alkaline phosphatase family
PAES_RS12145	COG1032	radical SAM domain protein