locus-tag	class	description
Ptc2401_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Ptc2401_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ptc2401_RS00025	COG0426	domain, Protein
Ptc2401_RS00035	COG0445	tRNA wobble uridine modification
Ptc2401_RS00050	COG2863	cytochrome
Ptc2401_RS00055	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ptc2401_RS00060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ptc2401_RS00065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ptc2401_RS00075	COG0187	DNA topoisomerase II activity
Ptc2401_RS00080	COG0792	nuclease activity
Ptc2401_RS00085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ptc2401_RS00090	COG1530	ribonuclease E activity
Ptc2401_RS00095	COG2171	N-acyltransferase activity
Ptc2401_RS00100	COG0793	Belongs to the peptidase S41A family
Ptc2401_RS00110	COG0644	oxidoreductase
Ptc2401_RS00115	COG0423	glycine-tRNA ligase activity
Ptc2401_RS00125	COG0425	Belongs to the sulfur carrier protein TusA family
Ptc2401_RS00130	COG1797	cobyrinic acid a,c-diamide synthase activity
Ptc2401_RS00135	COG2920	part of a sulfur-relay system
Ptc2401_RS00140	COG2221	Nitrite and sulphite reductase 4Fe-4S
Ptc2401_RS00145	COG2221	Nitrite and sulphite reductase 4Fe-4S
Ptc2401_RS00160	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Ptc2401_RS00165	COG2923	Belongs to the DsrF TusC family
Ptc2401_RS00205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ptc2401_RS00205	COG1648	precorrin-2 dehydrogenase activity
Ptc2401_RS00220	COG1619	proteins homologs of microcin C7 resistance protein MccF
Ptc2401_RS00230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Ptc2401_RS00240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ptc2401_RS00245	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Ptc2401_RS00255	COG3360	Dodecin
Ptc2401_RS00265	COG0243	molybdopterin cofactor binding
Ptc2401_RS00280	COG0425	Belongs to the sulfur carrier protein TusA family
Ptc2401_RS00285	COG2210	Belongs to the sulfur carrier protein TusA family
Ptc2401_RS00290	COG0514	ATP-dependent DNA helicase (RecQ)
Ptc2401_RS00305	COG2249	NAD(P)H dehydrogenase (quinone) activity
Ptc2401_RS00320	COG4176	ABC-type proline glycine betaine transport system permease component
Ptc2401_RS00340	COG1363	Peptidase, m42
Ptc2401_RS00345	COG0189	ligase activity
Ptc2401_RS00345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ptc2401_RS00350	COG0367	asparagine synthase
Ptc2401_RS00365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ptc2401_RS00375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Ptc2401_RS00385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Ptc2401_RS00395	COG1254	Belongs to the acylphosphatase family
Ptc2401_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ptc2401_RS00405	COG0284	orotidine-5'-phosphate decarboxylase activity
Ptc2401_RS00410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ptc2401_RS00415	COG1090	epimerase
Ptc2401_RS00420	COG0724	RNA recognition motif
Ptc2401_RS00425	COG3385	transposase activity
Ptc2401_RS00430	COG0004	ammonium transporteR
Ptc2401_RS00455	COG0802	atpase or kinase
Ptc2401_RS00460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ptc2401_RS00465	COG0799	negative regulation of ribosome biogenesis
Ptc2401_RS00480	COG0504	CTP synthase activity
Ptc2401_RS00520	COG0732	type I restriction modification DNA specificity domain
Ptc2401_RS00535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ptc2401_RS00595	COG0859	PFAM glycosyl transferase family 9
Ptc2401_RS00600	COG0360	Binds together with S18 to 16S ribosomal RNA
Ptc2401_RS00605	COG0629	single-stranded DNA binding
Ptc2401_RS00610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Ptc2401_RS00615	COG0359	binds to the 23S rRNA
Ptc2401_RS00625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Ptc2401_RS00630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Ptc2401_RS00635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Ptc2401_RS00640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ptc2401_RS00645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ptc2401_RS00650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ptc2401_RS00655	COG1472	Belongs to the glycosyl hydrolase 3 family
Ptc2401_RS00665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ptc2401_RS00670	COG0571	ribonuclease III activity
Ptc2401_RS00675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ptc2401_RS00680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ptc2401_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
Ptc2401_RS00690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ptc2401_RS00695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ptc2401_RS00700	COG0416	fatty acid biosynthetic process
Ptc2401_RS00720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ptc2401_RS00725	COG3385	transposase activity
Ptc2401_RS00730	COG0803	Belongs to the bacterial solute-binding protein 9 family
Ptc2401_RS00735	COG1121	(ABC) transporter
Ptc2401_RS00740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ptc2401_RS00760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ptc2401_RS00765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Ptc2401_RS00770	COG1381	Involved in DNA repair and RecF pathway recombination
Ptc2401_RS00790	COG0741	lytic transglycosylase activity
Ptc2401_RS00790	COG0739	heme binding
Ptc2401_RS00790	COG1196	nuclear chromosome segregation
Ptc2401_RS00800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Ptc2401_RS00805	COG0366	Alpha amylase catalytic
Ptc2401_RS00810	COG0366	Alpha amylase catalytic
Ptc2401_RS00815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ptc2401_RS00820	COG3956	TIGRFAM MazG family protein
Ptc2401_RS00825	COG0300	oxidoreductase activity
Ptc2401_RS00830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ptc2401_RS00835	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ptc2401_RS00860	COG2815	serine threonine protein kinase
Ptc2401_RS00860	COG0515	serine threonine protein kinase
Ptc2401_RS00900	COG0745	RESPONSE REGULATOR receiver
Ptc2401_RS00965	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Ptc2401_RS00970	COG0736	holo-[acyl-carrier-protein] synthase activity
Ptc2401_RS00975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Ptc2401_RS00995	COG0702	epimerase
Ptc2401_RS01010	COG3876	Protein conserved in bacteria
Ptc2401_RS01015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Ptc2401_RS01030	COG1032	radical SAM domain protein
Ptc2401_RS01070	COG2267	carboxylic ester hydrolase activity
Ptc2401_RS01075	COG1937	Protein conserved in bacteria
Ptc2401_RS01105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ptc2401_RS01115	COG1053	succinate dehydrogenase
Ptc2401_RS01120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ptc2401_RS01125	COG2048	Heterodisulfide reductase, subunit B
Ptc2401_RS01130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Ptc2401_RS01135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ptc2401_RS01140	COG0589	response to stress
Ptc2401_RS01145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Ptc2401_RS01150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Ptc2401_RS01165	COG0083	homoserine kinase activity
Ptc2401_RS01170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Ptc2401_RS01175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Ptc2401_RS01185	COG1546	Belongs to the CinA family
Ptc2401_RS01185	COG1058	Belongs to the CinA family
Ptc2401_RS01195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ptc2401_RS01215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ptc2401_RS01230	COG1216	Glycosyl transferase, family 2
Ptc2401_RS01235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ptc2401_RS01240	COG0148	phosphopyruvate hydratase activity
Ptc2401_RS01250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Ptc2401_RS01275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ptc2401_RS01280	COG0250	Participates in transcription elongation, termination and antitermination
Ptc2401_RS01285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Ptc2401_RS01290	COG0081	regulation of translation
Ptc2401_RS01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Ptc2401_RS01300	COG0222	ribosome binding
Ptc2401_RS01305	COG0085	RNA polymerase activity
Ptc2401_RS01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Ptc2401_RS01315	COG0439	Biotin carboxylase
Ptc2401_RS01320	COG0511	ligase activity, forming carbon-carbon bonds
Ptc2401_RS01325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ptc2401_RS01335	COG0825	malonyl-CoA metabolic process
Ptc2401_RS01340	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ptc2401_RS01345	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ptc2401_RS01345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ptc2401_RS01370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Ptc2401_RS01375	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ptc2401_RS01380	COG0560	Phosphoserine phosphatase
Ptc2401_RS01380	COG3830	Belongs to the UPF0237 family
Ptc2401_RS01385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ptc2401_RS01385	COG0519	Catalyzes the synthesis of GMP from XMP
Ptc2401_RS01395	COG2267	carboxylic ester hydrolase activity
Ptc2401_RS01415	COG2096	Adenosyltransferase
Ptc2401_RS01435	COG0542	response to heat
Ptc2401_RS01440	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Ptc2401_RS01450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Ptc2401_RS01455	COG0552	protein localization to endoplasmic reticulum
Ptc2401_RS01465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ptc2401_RS01470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ptc2401_RS01485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ptc2401_RS01490	COG0305	Participates in initiation and elongation during chromosome replication
Ptc2401_RS01495	COG1573	uracil-dna glycosylase
Ptc2401_RS01500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ptc2401_RS01505	COG1785	Belongs to the alkaline phosphatase family
Ptc2401_RS01540	COG0737	Belongs to the 5'-nucleotidase family
Ptc2401_RS01575	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Ptc2401_RS01580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Ptc2401_RS01580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Ptc2401_RS01605	COG0438	transferase activity, transferring glycosyl groups
Ptc2401_RS01615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ptc2401_RS01655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ptc2401_RS01670	COG3415	Transposase
Ptc2401_RS01670	COG2801	Transposase and inactivated derivatives
Ptc2401_RS01675	COG1132	(ABC) transporter
Ptc2401_RS01705	COG0438	transferase activity, transferring glycosyl groups
Ptc2401_RS01710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ptc2401_RS01715	COG2801	Transposase and inactivated derivatives
Ptc2401_RS01720	COG2963	transposase activity
Ptc2401_RS01725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Ptc2401_RS01740	COG0463	Glycosyl transferase, family 2
Ptc2401_RS01740	COG1216	Glycosyl transferase, family 2
Ptc2401_RS01755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Ptc2401_RS01790	COG2089	acid synthase
Ptc2401_RS01795	COG1083	cytidylyl-transferase
Ptc2401_RS01805	COG1671	Belongs to the UPF0178 family
Ptc2401_RS01815	COG0575	Belongs to the CDS family
Ptc2401_RS01830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ptc2401_RS01835	COG0124	histidyl-tRNA synthetase
Ptc2401_RS01845	COG0779	Required for maturation of 30S ribosomal subunits
Ptc2401_RS01850	COG0195	Participates in both transcription termination and antitermination
Ptc2401_RS01855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ptc2401_RS01860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Ptc2401_RS01865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Ptc2401_RS01870	COG0196	riboflavin kinase activity
Ptc2401_RS01875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Ptc2401_RS01880	COG1561	YicC-like family, N-terminal region
Ptc2401_RS01885	COG0194	GDP metabolic process
Ptc2401_RS01915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ptc2401_RS01920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Ptc2401_RS01935	COG0758	DNA mediated transformation
Ptc2401_RS01945	COG1304	FMN binding
Ptc2401_RS01950	COG4591	ABC-type transport system involved in lipoprotein release permease component
Ptc2401_RS01960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ptc2401_RS01965	COG1132	(ABC) transporter
Ptc2401_RS01970	COG0268	Binds directly to 16S ribosomal RNA
Ptc2401_RS01975	COG0632	four-way junction helicase activity
Ptc2401_RS01980	COG0285	dihydrofolate synthase activity
Ptc2401_RS02005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Ptc2401_RS02010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Ptc2401_RS02015	COG2086	electron transfer activity
Ptc2401_RS02020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Ptc2401_RS02040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ptc2401_RS02045	COG0154	amidase activity
Ptc2401_RS02050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Ptc2401_RS02055	COG0517	IMP dehydrogenase activity
Ptc2401_RS02055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Ptc2401_RS02095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ptc2401_RS02100	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ptc2401_RS02130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Ptc2401_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
Ptc2401_RS02155	COG1136	(ABC) transporter
Ptc2401_RS02165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ptc2401_RS02175	COG2226	methyltransferase
Ptc2401_RS02180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Ptc2401_RS02205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ptc2401_RS02205	COG0493	'glutamate synthase
Ptc2401_RS02210	COG0543	2 iron, 2 sulfur cluster binding
Ptc2401_RS02215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Ptc2401_RS02220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Ptc2401_RS02225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Ptc2401_RS02230	COG1187	pseudouridine synthase activity
Ptc2401_RS02240	COG0009	L-threonylcarbamoyladenylate synthase
Ptc2401_RS02250	COG0248	Ppx GppA phosphatase
Ptc2401_RS02250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ptc2401_RS02270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Ptc2401_RS02275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ptc2401_RS02285	COG1196	nuclear chromosome segregation
Ptc2401_RS02290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Ptc2401_RS02325	COG1127	ABC transporter
Ptc2401_RS02330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Ptc2401_RS02335	COG0613	PHP domain protein
Ptc2401_RS02340	COG1968	undecaprenyl-diphosphatase activity
Ptc2401_RS02345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Ptc2401_RS02350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Ptc2401_RS02355	COG1193	negative regulation of DNA recombination
Ptc2401_RS02360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ptc2401_RS02365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Ptc2401_RS02370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ptc2401_RS02400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Ptc2401_RS02405	COG0003	Pfam Anion-transporting ATPase
Ptc2401_RS02410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Ptc2401_RS02425	COG1692	metallophosphoesterase
Ptc2401_RS02435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Ptc2401_RS02445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ptc2401_RS02455	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Ptc2401_RS02470	COG1663	tetraacyldisaccharide 4'-kinase activity
Ptc2401_RS02480	COG0151	Belongs to the GarS family
Ptc2401_RS02490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Ptc2401_RS02495	COG0134	indole-3-glycerol-phosphate synthase activity
Ptc2401_RS02500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Ptc2401_RS02515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ptc2401_RS02515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ptc2401_RS02520	COG0077	Prephenate dehydratase
Ptc2401_RS02520	COG1605	Chorismate mutase
Ptc2401_RS02525	COG0217	transcriptional regulatory protein
Ptc2401_RS02530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Ptc2401_RS02535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ptc2401_RS02540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Ptc2401_RS02540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ptc2401_RS02545	COG0483	inositol monophosphate 1-phosphatase activity
Ptc2401_RS02580	COG1715	Restriction endonuclease
Ptc2401_RS02590	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Ptc2401_RS02595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ptc2401_RS02600	COG0495	leucyl-tRNA aminoacylation
Ptc2401_RS02605	COG1185	polyribonucleotide nucleotidyltransferase activity
Ptc2401_RS02610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Ptc2401_RS02615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Ptc2401_RS02620	COG4608	Belongs to the ABC transporter superfamily
Ptc2401_RS02625	COG0616	signal peptide processing
Ptc2401_RS02630	COG0606	chelatase, subunit chli
Ptc2401_RS02635	COG3245	cytochrome
Ptc2401_RS02640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Ptc2401_RS02655	COG4974	Belongs to the 'phage' integrase family
Ptc2401_RS02665	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Ptc2401_RS02675	COG0601	transmembrane transport
Ptc2401_RS02680	COG2255	four-way junction helicase activity
Ptc2401_RS02690	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ptc2401_RS02690	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ptc2401_RS02690	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ptc2401_RS02690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ptc2401_RS02695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ptc2401_RS02700	COG0509	glycine decarboxylation via glycine cleavage system
Ptc2401_RS02705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ptc2401_RS02710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ptc2401_RS02715	COG0497	DNA recombination
Ptc2401_RS02725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ptc2401_RS02730	COG0688	phosphatidylethanolamine metabolic process
Ptc2401_RS02735	COG0037	tRNA processing
Ptc2401_RS02745	COG0328	RNA-DNA hybrid ribonuclease activity
Ptc2401_RS02750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Ptc2401_RS02755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ptc2401_RS02760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ptc2401_RS02765	COG0006	proline dipeptidase activity
Ptc2401_RS02775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Ptc2401_RS02780	COG0205	6-phosphofructokinase activity
Ptc2401_RS02785	COG4591	ABC-type transport system involved in lipoprotein release permease component
Ptc2401_RS02790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Ptc2401_RS02810	COG1528	Iron-storage protein
Ptc2401_RS02820	COG1528	Iron-storage protein
Ptc2401_RS02825	COG0716	FMN binding
Ptc2401_RS02850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ptc2401_RS02880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Ptc2401_RS02885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ptc2401_RS02885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ptc2401_RS02890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Ptc2401_RS02900	COG0107	imidazoleglycerol-phosphate synthase activity
Ptc2401_RS02910	COG0492	ferredoxin-NADP+ reductase activity
Ptc2401_RS02915	COG1575	Belongs to the MenA family. Type 1 subfamily
Ptc2401_RS02925	COG1283	sodium-dependent phosphate transmembrane transporter activity
Ptc2401_RS02935	COG0501	Belongs to the peptidase M48B family
Ptc2401_RS02945	COG0039	L-malate dehydrogenase activity
Ptc2401_RS02950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Ptc2401_RS02955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Ptc2401_RS02965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Ptc2401_RS02970	COG1132	(ABC) transporter
Ptc2401_RS02985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Ptc2401_RS02990	COG2204	response regulator
Ptc2401_RS03000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ptc2401_RS03010	COG2252	PERMEase
Ptc2401_RS03015	COG0450	alkyl hydroperoxide reductase
Ptc2401_RS03020	COG0442	prolyl-tRNA aminoacylation
Ptc2401_RS03030	COG2890	protein-(glutamine-N5) methyltransferase activity
Ptc2401_RS03035	COG1420	regulation of RNA biosynthetic process
Ptc2401_RS03040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ptc2401_RS03045	COG0484	heat shock protein binding
Ptc2401_RS03050	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ptc2401_RS03060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ptc2401_RS03070	COG1136	(ABC) transporter
Ptc2401_RS03080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Ptc2401_RS03085	COG3263	regulation of cellular component size
Ptc2401_RS03095	COG0668	transmembrane transport
Ptc2401_RS03100	COG0242	peptide deformylase activity
Ptc2401_RS03105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Ptc2401_RS03110	COG0481	GTPase activity
Ptc2401_RS03130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ptc2401_RS03135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ptc2401_RS03145	COG0149	triose-phosphate isomerase activity
Ptc2401_RS03155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Ptc2401_RS03165	COG0731	radical SAM domain protein
Ptc2401_RS03165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ptc2401_RS03170	COG0513	Belongs to the DEAD box helicase family
Ptc2401_RS03185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Ptc2401_RS03190	COG0113	porphobilinogen synthase activity
Ptc2401_RS03205	COG1587	Uroporphyrinogen-III synthase
Ptc2401_RS03210	COG0181	hydroxymethylbilane synthase activity
Ptc2401_RS03215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Ptc2401_RS03220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ptc2401_RS03225	COG1217	gtp-binding protein TYPA
Ptc2401_RS03230	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Ptc2401_RS03235	COG1063	alcohol dehydrogenase
Ptc2401_RS03250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Ptc2401_RS03255	COG0756	dUTP diphosphatase activity
Ptc2401_RS03270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Ptc2401_RS03270	COG0493	'glutamate synthase
Ptc2401_RS03280	COG1522	sequence-specific DNA binding
Ptc2401_RS03300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Ptc2401_RS03305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ptc2401_RS03310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ptc2401_RS03320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Ptc2401_RS03325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ptc2401_RS03330	COG0343	queuine tRNA-ribosyltransferase activity
Ptc2401_RS03350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Ptc2401_RS03355	COG1562	ergosterol biosynthetic process
Ptc2401_RS03360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Ptc2401_RS03365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Ptc2401_RS03370	COG0735	belongs to the Fur family
Ptc2401_RS03375	COG0450	alkyl hydroperoxide reductase
Ptc2401_RS03410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Ptc2401_RS03415	COG0019	diaminopimelate decarboxylase activity
Ptc2401_RS03420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Ptc2401_RS03425	COG0658	competence protein
Ptc2401_RS03425	COG2333	competence protein COMEC
Ptc2401_RS03435	COG0494	nUDIX hydrolase
Ptc2401_RS03440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ptc2401_RS03445	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Ptc2401_RS03450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ptc2401_RS03455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ptc2401_RS03460	COG2885	chlorophyll binding
Ptc2401_RS03465	COG0577	efflux transmembrane transporter activity
Ptc2401_RS03465	COG1136	(ABC) transporter
Ptc2401_RS03470	COG1136	(ABC) transporter
Ptc2401_RS03470	COG0577	efflux transmembrane transporter activity
Ptc2401_RS03475	COG1136	(ABC) transporter
Ptc2401_RS03495	COG1181	Belongs to the D-alanine--D-alanine ligase family
Ptc2401_RS03500	COG1832	CoA-binding protein
Ptc2401_RS03510	COG0095	Lipoate-protein ligase
Ptc2401_RS03515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Ptc2401_RS03520	COG1183	phosphatidylcholine synthase activity
Ptc2401_RS03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ptc2401_RS03530	COG0047	phosphoribosylformylglycinamidine synthase activity
Ptc2401_RS03535	COG2270	Major facilitator Superfamily
Ptc2401_RS03540	COG1295	ribonuclease BN
Ptc2401_RS03545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ptc2401_RS03550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ptc2401_RS03560	COG1032	radical SAM domain protein
Ptc2401_RS03565	COG2050	protein possibly involved in aromatic compounds catabolism
Ptc2401_RS03580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Ptc2401_RS03585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ptc2401_RS03600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Ptc2401_RS03615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ptc2401_RS03620	COG0488	(ABC) transporter
Ptc2401_RS03625	COG1770	oligopeptidase
Ptc2401_RS03630	COG0564	pseudouridine synthase activity
Ptc2401_RS03635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ptc2401_RS03640	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Ptc2401_RS03645	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Ptc2401_RS03645	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Ptc2401_RS03650	COG1429	ligase activity, forming nitrogen-metal bonds
Ptc2401_RS03670	COG0516	GMP reductase activity
Ptc2401_RS03680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ptc2401_RS03680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ptc2401_RS03695	COG0428	transporter
Ptc2401_RS03705	COG1216	Glycosyl transferase, family 2
Ptc2401_RS03705	COG0463	Glycosyl transferase, family 2
Ptc2401_RS03715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ptc2401_RS03725	COG1702	phosphate starvation-inducible protein PhoH
Ptc2401_RS03740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ptc2401_RS03745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ptc2401_RS03750	COG0596	Alpha beta hydrolase
Ptc2401_RS03755	COG0193	aminoacyl-tRNA hydrolase activity
Ptc2401_RS03760	COG5002	protein histidine kinase activity
Ptc2401_RS03765	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Ptc2401_RS03780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ptc2401_RS03795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ptc2401_RS03800	COG0742	ribosomal rna small subunit methyltransferase
Ptc2401_RS03805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ptc2401_RS03810	COG0436	Aminotransferase
Ptc2401_RS03820	COG1774	PSP1 C-terminal conserved region
Ptc2401_RS03825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ptc2401_RS03825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ptc2401_RS03845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ptc2401_RS03870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ptc2401_RS03890	COG2244	polysaccharide biosynthetic process
Ptc2401_RS03935	COG0028	Belongs to the TPP enzyme family
Ptc2401_RS03935	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Ptc2401_RS03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ptc2401_RS04000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Ptc2401_RS04015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Ptc2401_RS04025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Ptc2401_RS04060	COG1216	Glycosyl transferase, family 2
Ptc2401_RS04080	COG2963	transposase activity
Ptc2401_RS04095	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ptc2401_RS04115	COG3258	Cytochrome c
Ptc2401_RS04130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ptc2401_RS04135	COG4232	protein-disulfide reductase activity
Ptc2401_RS04140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ptc2401_RS04150	COG3344	reverse transcriptase
Ptc2401_RS04185	COG0626	cystathionine gamma-synthase activity
Ptc2401_RS04190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ptc2401_RS04195	COG1320	monovalent cation:proton antiporter activity
Ptc2401_RS04200	COG2212	antiporter activity
Ptc2401_RS04205	COG1863	multisubunit Na H antiporter MnhE subunit
Ptc2401_RS04210	COG0651	ATP synthesis coupled electron transport
Ptc2401_RS04215	COG1006	Multisubunit Na H antiporter MnhC subunit
Ptc2401_RS04220	COG2111	Na H antiporter
Ptc2401_RS04225	COG2111	Na H antiporter
Ptc2401_RS04225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ptc2401_RS04235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ptc2401_RS04330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ptc2401_RS04335	COG0003	Pfam Anion-transporting ATPase
Ptc2401_RS04415	COG0443	Heat shock 70 kDa protein
Ptc2401_RS04420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ptc2401_RS04425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ptc2401_RS04445	COG4942	peptidase
Ptc2401_RS04475	COG2801	Transposase and inactivated derivatives
Ptc2401_RS04485	COG0431	NADPH-dependent FMN reductase
Ptc2401_RS04495	COG0310	cobalt ion transport
Ptc2401_RS04525	COG0189	ligase activity
Ptc2401_RS04525	COG0569	domain protein
Ptc2401_RS04530	COG0798	PFAM Bile acid sodium symporter
Ptc2401_RS04535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ptc2401_RS04555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ptc2401_RS04560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ptc2401_RS04590	COG0535	radical SAM domain protein
Ptc2401_RS04600	COG5002	protein histidine kinase activity
Ptc2401_RS04605	COG4206	TonB-dependent receptor
Ptc2401_RS04615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ptc2401_RS04620	COG1116	anion transmembrane transporter activity
Ptc2401_RS04635	COG0003	Pfam Anion-transporting ATPase
Ptc2401_RS04680	COG0300	oxidoreductase activity
Ptc2401_RS04685	COG1030	water channel activity
Ptc2401_RS04690	COG0330	HflC and HflK could
Ptc2401_RS04695	COG0589	response to stress
Ptc2401_RS04705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Ptc2401_RS04710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ptc2401_RS04715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Ptc2401_RS04720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ptc2401_RS04725	COG0493	'glutamate synthase
Ptc2401_RS04725	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Ptc2401_RS04760	COG3415	Transposase
Ptc2401_RS04760	COG2801	Transposase and inactivated derivatives
Ptc2401_RS04770	COG0659	secondary active sulfate transmembrane transporter activity
Ptc2401_RS04775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Ptc2401_RS04795	COG1136	(ABC) transporter
Ptc2401_RS04810	COG0114	fumarate hydratase activity
Ptc2401_RS04815	COG2326	polyphosphate kinase activity
Ptc2401_RS04835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Ptc2401_RS04840	COG0326	Molecular chaperone. Has ATPase activity
Ptc2401_RS04855	COG0589	response to stress
Ptc2401_RS04880	COG1554	hydrolase, family 65, central catalytic
Ptc2401_RS04885	COG0438	transferase activity, transferring glycosyl groups
Ptc2401_RS04890	COG0587	DNA-directed DNA polymerase activity
Ptc2401_RS04895	COG3118	belongs to the thioredoxin family
Ptc2401_RS04900	COG0492	ferredoxin-NADP+ reductase activity
Ptc2401_RS04910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ptc2401_RS04925	COG0546	phosphoglycolate phosphatase activity
Ptc2401_RS04930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ptc2401_RS04955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ptc2401_RS04960	COG0573	inorganic phosphate transmembrane transporter activity
Ptc2401_RS04965	COG0581	inorganic phosphate transmembrane transporter activity
Ptc2401_RS04970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Ptc2401_RS04975	COG0704	Plays a role in the regulation of phosphate uptake
Ptc2401_RS05010	COG0277	FAD linked oxidase domain protein
Ptc2401_RS05015	COG0436	Aminotransferase
Ptc2401_RS05050	COG3385	transposase activity
Ptc2401_RS05080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ptc2401_RS05080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ptc2401_RS05085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ptc2401_RS05090	COG0653	protein targeting
Ptc2401_RS05095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Ptc2401_RS05100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ptc2401_RS05125	COG0351	phosphomethylpyrimidine kinase
Ptc2401_RS05130	COG0352	thiamine-phosphate diphosphorylase activity
Ptc2401_RS05135	COG0352	thiamine-phosphate diphosphorylase activity
Ptc2401_RS05140	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Ptc2401_RS05145	COG0251	oxidation-reduction process
Ptc2401_RS05150	COG0793	Belongs to the peptidase S41A family
Ptc2401_RS05165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Ptc2401_RS05165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Ptc2401_RS05170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ptc2401_RS05175	COG0228	four-way junction DNA binding
Ptc2401_RS05180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Ptc2401_RS05185	COG0336	Belongs to the RNA methyltransferase TrmD family
Ptc2401_RS05190	COG0335	large ribosomal subunit rRNA binding
Ptc2401_RS05195	COG1194	a g-specific adenine glycosylase
Ptc2401_RS05200	COG1022	Amp-dependent synthetase and ligase
Ptc2401_RS05220	COG1744	ABC transporter substrate-binding protein PnrA-like
Ptc2401_RS05235	COG0517	IMP dehydrogenase activity
Ptc2401_RS05245	COG2226	methyltransferase
Ptc2401_RS05245	COG0596	Alpha beta hydrolase
Ptc2401_RS05245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Ptc2401_RS05255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Ptc2401_RS05260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Ptc2401_RS05265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Ptc2401_RS05270	COG0698	ribose 5-phosphate isomerase
Ptc2401_RS05280	COG1473	amidohydrolase
Ptc2401_RS05285	COG0191	fructose-bisphosphate aldolase activity
Ptc2401_RS05290	COG0793	Belongs to the peptidase S41A family
Ptc2401_RS05295	COG0165	Argininosuccinate lyase
Ptc2401_RS05310	COG0318	PFAM AMP-dependent synthetase and ligase
Ptc2401_RS05315	COG1858	cytochrome C peroxidase
Ptc2401_RS05325	COG0137	argininosuccinate synthase activity
Ptc2401_RS05330	COG1438	arginine binding
Ptc2401_RS05335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Ptc2401_RS05340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ptc2401_RS05345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Ptc2401_RS05350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Ptc2401_RS05360	COG3706	GGDEF domain
Ptc2401_RS05360	COG4251	negative regulation of phosphorylation
Ptc2401_RS05360	COG5001	Diguanylate cyclase
Ptc2401_RS05360	COG2203	Gaf domain
Ptc2401_RS05375	COG1773	rubredoxin
Ptc2401_RS05390	COG2119	membrane
Ptc2401_RS05395	COG4619	ABC transporter
Ptc2401_RS05400	COG0390	transport system, permease component
Ptc2401_RS05405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Ptc2401_RS05410	COG0045	succinate-CoA ligase (ADP-forming) activity
Ptc2401_RS05415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Ptc2401_RS05425	COG2208	phosphoserine phosphatase activity
Ptc2401_RS05430	COG2204	response regulator
Ptc2401_RS05435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ptc2401_RS05450	COG1366	Belongs to the anti-sigma-factor antagonist family
Ptc2401_RS05465	COG1045	serine acetyltransferase
Ptc2401_RS05500	COG0438	transferase activity, transferring glycosyl groups
Ptc2401_RS05525	COG0438	transferase activity, transferring glycosyl groups
Ptc2401_RS05535	COG1132	(ABC) transporter
Ptc2401_RS05565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ptc2401_RS05570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ptc2401_RS05585	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Ptc2401_RS05590	COG5002	protein histidine kinase activity
Ptc2401_RS05605	COG3385	transposase activity
Ptc2401_RS05610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Ptc2401_RS05620	COG2205	protein histidine kinase activity
Ptc2401_RS05625	COG5002	protein histidine kinase activity
Ptc2401_RS05630	COG3409	Peptidoglycan-binding domain 1 protein
Ptc2401_RS05630	COG3773	Cell wall hydrolase
Ptc2401_RS05635	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ptc2401_RS05645	COG2201	protein-glutamate methylesterase activity
Ptc2401_RS05650	COG0745	RESPONSE REGULATOR receiver
Ptc2401_RS05655	COG1151	hydroxylamine reductase activity
Ptc2401_RS05705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ptc2401_RS05710	COG2824	Alkylphosphonate utilization operon protein PhnA
Ptc2401_RS05715	COG0633	Ferredoxin
Ptc2401_RS05720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ptc2401_RS05725	COG3318	Belongs to the UPF0149 family
Ptc2401_RS05730	COG1074	ATP-dependent DNA helicase activity
Ptc2401_RS05730	COG1074	ATP-dependent DNA helicase activity
Ptc2401_RS05745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ptc2401_RS05750	COG1509	lysine 2,3-aminomutase activity
Ptc2401_RS05775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Ptc2401_RS05785	COG0563	adenylate kinase activity
Ptc2401_RS05790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ptc2401_RS05805	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Ptc2401_RS05810	COG0670	Belongs to the BI1 family
Ptc2401_RS05815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Ptc2401_RS05820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Ptc2401_RS05835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Ptc2401_RS05840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Ptc2401_RS05845	COG1950	PFAM Membrane protein of
Ptc2401_RS05855	COG3845	ABC transporter
Ptc2401_RS05860	COG4603	Belongs to the binding-protein-dependent transport system permease family
Ptc2401_RS05865	COG0038	chloride channel
Ptc2401_RS05880	COG0142	geranyltranstransferase activity
Ptc2401_RS05890	COG0805	protein transport
Ptc2401_RS05900	COG0237	dephospho-CoA kinase activity
Ptc2401_RS05910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ptc2401_RS05920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Ptc2401_RS05925	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Ptc2401_RS05930	COG3118	belongs to the thioredoxin family
Ptc2401_RS05975	COG2081	HI0933 family
Ptc2401_RS06020	COG1454	alcohol dehydrogenase
Ptc2401_RS06035	COG1342	Belongs to the UPF0251 family
Ptc2401_RS06050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Ptc2401_RS06060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Ptc2401_RS06075	COG1120	ATPase activity
Ptc2401_RS06080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ptc2401_RS06085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Ptc2401_RS06090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ptc2401_RS06095	COG1492	cobalamin metabolic process
Ptc2401_RS06110	COG4771	TonB-dependent receptor
Ptc2401_RS06115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ptc2401_RS06120	COG1120	ATPase activity
Ptc2401_RS06125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Ptc2401_RS06160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ptc2401_RS06160	COG1648	precorrin-2 dehydrogenase activity
Ptc2401_RS06165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Ptc2401_RS06180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Ptc2401_RS06190	COG2878	Part of a membrane complex involved in electron transport
Ptc2401_RS06190	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ptc2401_RS06195	COG4656	Part of a membrane complex involved in electron transport
Ptc2401_RS06200	COG4658	electron transport chain
Ptc2401_RS06210	COG4660	Part of a membrane complex involved in electron transport
Ptc2401_RS06215	COG4657	Part of a membrane complex involved in electron transport
Ptc2401_RS06230	COG0166	Belongs to the GPI family
Ptc2401_RS06240	COG0004	ammonium transporteR
Ptc2401_RS06245	COG0347	Belongs to the P(II) protein family
Ptc2401_RS06255	COG0456	acetyltransferase
Ptc2401_RS06265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Ptc2401_RS06275	COG1388	LysM domain
Ptc2401_RS06275	COG1705	Flagellar rod assembly protein muramidase FlgJ
Ptc2401_RS06280	COG0101	tRNA pseudouridine synthase activity
Ptc2401_RS06305	COG0424	maF-like protein
Ptc2401_RS06310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Ptc2401_RS06320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ptc2401_RS06340	COG3876	Protein conserved in bacteria
Ptc2401_RS06360	COG1218	3'(2'),5'-bisphosphate nucleotidase
Ptc2401_RS06395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Ptc2401_RS06415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Ptc2401_RS06425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ptc2401_RS06535	COG0653	protein targeting
Ptc2401_RS06565	COG3012	SEC-C Motif Domain Protein
Ptc2401_RS06565	COG3318	Belongs to the UPF0149 family
Ptc2401_RS06590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ptc2401_RS06620	COG3657	addiction module killer protein
Ptc2401_RS06645	COG3657	addiction module killer protein
Ptc2401_RS06655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ptc2401_RS06660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ptc2401_RS06665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Ptc2401_RS06675	COG5434	Belongs to the glycosyl hydrolase 28 family
Ptc2401_RS06680	COG0673	inositol 2-dehydrogenase activity
Ptc2401_RS06700	COG2801	Transposase and inactivated derivatives
Ptc2401_RS06710	COG4249	Peptidase C14 caspase catalytic subunit p20
Ptc2401_RS06735	COG3415	Transposase
Ptc2401_RS06735	COG2801	Transposase and inactivated derivatives
Ptc2401_RS06765	COG1196	nuclear chromosome segregation
Ptc2401_RS06815	COG3118	belongs to the thioredoxin family
Ptc2401_RS06825	COG0302	gtp cyclohydrolase
Ptc2401_RS06830	COG0628	permease
Ptc2401_RS06835	COG1007	ATP synthesis coupled electron transport
Ptc2401_RS06850	COG0713	ATP synthesis coupled electron transport
Ptc2401_RS06865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Ptc2401_RS06870	COG0649	NAD binding
Ptc2401_RS06875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ptc2401_RS06880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ptc2401_RS06885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ptc2401_RS06935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ptc2401_RS06940	COG0307	riboflavin synthase, alpha
Ptc2401_RS06945	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Ptc2401_RS06955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ptc2401_RS06955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ptc2401_RS07035	COG0131	Imidazoleglycerol-phosphate dehydratase
Ptc2401_RS07040	COG1418	mRNA catabolic process
Ptc2401_RS07055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ptc2401_RS07055	COG0072	phenylalanine-tRNA ligase activity
Ptc2401_RS07085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ptc2401_RS07100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ptc2401_RS07105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Ptc2401_RS07110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Ptc2401_RS07120	COG0135	phosphoribosylanthranilate isomerase activity
Ptc2401_RS07150	COG0668	transmembrane transport
Ptc2401_RS07165	COG1566	PFAM secretion protein HlyD family protein
Ptc2401_RS07190	COG0456	acetyltransferase
Ptc2401_RS07190	COG0454	-acetyltransferase
Ptc2401_RS07230	COG1253	flavin adenine dinucleotide binding
Ptc2401_RS07235	COG0419	ATPase involved in DNA repair
Ptc2401_RS07245	COG0420	3'-5' exonuclease activity
Ptc2401_RS07255	COG0514	ATP-dependent DNA helicase (RecQ)
Ptc2401_RS07260	COG3177	Filamentation induced by cAMP protein fic
Ptc2401_RS07265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ptc2401_RS07275	COG4804	nuclease activity
Ptc2401_RS07280	COG2801	Transposase and inactivated derivatives
Ptc2401_RS07280	COG3415	Transposase
Ptc2401_RS07295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ptc2401_RS07325	COG3385	transposase activity
Ptc2401_RS07345	COG1401	restriction endodeoxyribonuclease activity
Ptc2401_RS07405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ptc2401_RS07430	COG1678	Uncharacterized ACR, COG1678
Ptc2401_RS07435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ptc2401_RS07445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ptc2401_RS07450	COG0668	transmembrane transport
Ptc2401_RS07455	COG5002	protein histidine kinase activity
Ptc2401_RS07460	COG0745	RESPONSE REGULATOR receiver
Ptc2401_RS07465	COG0444	Belongs to the ABC transporter superfamily
Ptc2401_RS07470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ptc2401_RS07475	COG0633	Ferredoxin
Ptc2401_RS07480	COG0633	Ferredoxin
Ptc2401_RS07485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ptc2401_RS07490	COG0686	Belongs to the AlaDH PNT family
Ptc2401_RS07500	COG1595	DNA-templated transcription, initiation
Ptc2401_RS07515	COG0071	Belongs to the small heat shock protein (HSP20) family
Ptc2401_RS07520	COG0443	Heat shock 70 kDa protein
Ptc2401_RS07540	COG2885	chlorophyll binding
Ptc2401_RS07545	COG2885	chlorophyll binding
Ptc2401_RS07550	COG0823	Involved in the tonB-independent uptake of proteins
Ptc2401_RS07570	COG1836	PFAM Integral membrane protein DUF92
Ptc2401_RS07575	COG0129	dihydroxy-acid dehydratase activity
Ptc2401_RS07580	COG0028	Belongs to the TPP enzyme family
Ptc2401_RS07585	COG0440	acetolactate synthase activity
Ptc2401_RS07590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Ptc2401_RS07595	COG0473	3-isopropylmalate dehydrogenase activity
Ptc2401_RS07605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ptc2401_RS07610	COG0066	3-isopropylmalate dehydratase activity
Ptc2401_RS07615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ptc2401_RS07620	COG2003	Belongs to the UPF0758 family
Ptc2401_RS07625	COG1278	Cold shock
Ptc2401_RS07630	COG4221	oxidoreductase activity
Ptc2401_RS07640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ptc2401_RS07645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Ptc2401_RS07650	COG2873	o-acetylhomoserine
Ptc2401_RS07655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ptc2401_RS07655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ptc2401_RS07660	COG4974	Belongs to the 'phage' integrase family
Ptc2401_RS07665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Ptc2401_RS07700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Ptc2401_RS07705	COG2884	Cell division ATP-binding protein ftsE
Ptc2401_RS07715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Ptc2401_RS07720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ptc2401_RS07740	COG0768	penicillin binding
Ptc2401_RS07745	COG0277	FAD linked oxidase domain protein
Ptc2401_RS07750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Ptc2401_RS07755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Ptc2401_RS07760	COG1945	arginine decarboxylase activity
Ptc2401_RS07770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Ptc2401_RS07775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Ptc2401_RS07790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ptc2401_RS07825	COG1049	propionate catabolic process, 2-methylcitrate cycle
Ptc2401_RS07830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ptc2401_RS07835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Ptc2401_RS07840	COG1077	Cell shape determining protein MreB Mrl
Ptc2401_RS07845	COG1404	Belongs to the peptidase S8 family
Ptc2401_RS07850	COG4191	Histidine kinase
Ptc2401_RS07855	COG2204	response regulator
Ptc2401_RS07875	COG0438	transferase activity, transferring glycosyl groups
Ptc2401_RS07880	COG2814	Major facilitator Superfamily
Ptc2401_RS07895	COG0159	tryptophan synthase activity
Ptc2401_RS07905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Ptc2401_RS07910	COG0459	protein refolding
Ptc2401_RS07915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ptc2401_RS07925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ptc2401_RS07945	COG0133	tryptophan synthase activity
Ptc2401_RS07960	COG3093	addiction module antidote protein HigA
Ptc2401_RS07975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ptc2401_RS07980	COG3385	transposase activity
Ptc2401_RS07990	COG0732	type I restriction modification DNA specificity domain
Ptc2401_RS08000	COG3415	Transposase
Ptc2401_RS08000	COG2801	Transposase and inactivated derivatives
Ptc2401_RS08020	COG3385	transposase activity
Ptc2401_RS08045	COG1857	crispr-associated protein
Ptc2401_RS08055	COG1518	maintenance of DNA repeat elements
Ptc2401_RS08060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ptc2401_RS08070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ptc2401_RS08070	COG0519	Catalyzes the synthesis of GMP from XMP
Ptc2401_RS08080	COG0557	exoribonuclease II activity
Ptc2401_RS08085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ptc2401_RS08100	COG2193	ferroxidase activity
Ptc2401_RS08110	COG0735	belongs to the Fur family
Ptc2401_RS08130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ptc2401_RS08165	COG2801	Transposase and inactivated derivatives
Ptc2401_RS08165	COG3415	Transposase
Ptc2401_RS08195	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Ptc2401_RS08205	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Ptc2401_RS08240	COG2217	Heavy metal translocating P-type atpase
Ptc2401_RS08245	COG2608	mercury ion transmembrane transporter activity
Ptc2401_RS08300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Ptc2401_RS08305	COG2176	DNA-directed DNA polymerase activity
Ptc2401_RS08310	COG0501	Belongs to the peptidase M48B family
Ptc2401_RS08315	COG0659	secondary active sulfate transmembrane transporter activity
Ptc2401_RS08320	COG0589	response to stress
Ptc2401_RS08345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ptc2401_RS08355	COG0493	'glutamate synthase
Ptc2401_RS08360	COG0067	glutamate synthase
Ptc2401_RS08360	COG0069	glutamate synthase activity
Ptc2401_RS08360	COG0070	glutamate synthase
Ptc2401_RS08365	COG0588	phosphoglycerate mutase activity
Ptc2401_RS08370	COG2070	2-Nitropropane dioxygenase
Ptc2401_RS08380	COG0590	tRNA wobble adenosine to inosine editing
Ptc2401_RS08385	COG0045	succinate-CoA ligase (ADP-forming) activity
Ptc2401_RS08390	COG0488	(ABC) transporter
Ptc2401_RS08400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ptc2401_RS08405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Ptc2401_RS08425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ptc2401_RS08450	COG0811	peptide transport
Ptc2401_RS08455	COG0358	DNA primase activity
Ptc2401_RS08475	COG0598	Magnesium transport protein CorA
Ptc2401_RS08495	COG4771	TonB-dependent receptor
Ptc2401_RS08505	COG0811	peptide transport
Ptc2401_RS08510	COG0848	biopolymer transport protein
Ptc2401_RS08515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Ptc2401_RS08540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ptc2401_RS08550	COG4149	molybdate abc transporter
Ptc2401_RS08555	COG0725	ABC transporter, periplasmic molybdate-binding protein
Ptc2401_RS08565	COG0535	radical SAM domain protein
Ptc2401_RS08565	COG1433	Dinitrogenase iron-molybdenum cofactor
Ptc2401_RS08590	COG0347	Belongs to the P(II) protein family
Ptc2401_RS08600	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Ptc2401_RS08620	COG0298	carbon dioxide binding
Ptc2401_RS08625	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Ptc2401_RS08635	COG0375	protein maturation
Ptc2401_RS08640	COG0540	Belongs to the ATCase OTCase family
Ptc2401_RS08665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Ptc2401_RS08670	COG0322	excinuclease ABC activity
Ptc2401_RS08680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Ptc2401_RS08685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Ptc2401_RS08690	COG0084	hydrolase, TatD family'
Ptc2401_RS08705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ptc2401_RS08710	COG0436	Aminotransferase
Ptc2401_RS08715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Ptc2401_RS08720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Ptc2401_RS08725	COG1271	oxidase subunit
Ptc2401_RS08730	COG1294	oxidase, subunit
Ptc2401_RS08735	COG4988	ABC transporter
Ptc2401_RS08740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Ptc2401_RS08745	COG3040	lipid binding
Ptc2401_RS08750	COG0788	formyltetrahydrofolate deformylase activity
Ptc2401_RS08765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Ptc2401_RS08770	COG0463	Glycosyl transferase, family 2
Ptc2401_RS08780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Ptc2401_RS08780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ptc2401_RS08785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Ptc2401_RS08790	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Ptc2401_RS08795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ptc2401_RS08800	COG0138	bifunctional purine biosynthesis protein purh
Ptc2401_RS08805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Ptc2401_RS08810	COG0602	queuosine metabolic process
Ptc2401_RS08815	COG0463	Glycosyl transferase, family 2
Ptc2401_RS08820	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Ptc2401_RS08825	COG2177	Part of the ABC transporter FtsEX involved in
Ptc2401_RS08835	COG1079	Belongs to the binding-protein-dependent transport system permease family
Ptc2401_RS08840	COG0574	Belongs to the PEP-utilizing enzyme family
Ptc2401_RS08840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ptc2401_RS08845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ptc2401_RS08855	COG0745	RESPONSE REGULATOR receiver
Ptc2401_RS08890	COG2948	multi-organism process
Ptc2401_RS08900	COG3701	Conjugal transfer protein
Ptc2401_RS08905	COG3846	protein secretion by the type IV secretion system
Ptc2401_RS08915	COG3451	type IV secretory pathway VirB4
Ptc2401_RS08925	COG3838	Conjugal transfer protein Trbc
Ptc2401_RS08930	COG4962	Type ii secretion system protein e
Ptc2401_RS08950	COG1091	dTDP-4-dehydrorhamnose reductase activity
Ptc2401_RS08985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Ptc2401_RS09005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ptc2401_RS09010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ptc2401_RS09015	COG0730	response to heat
Ptc2401_RS09020	COG0776	regulation of translation
Ptc2401_RS09035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Ptc2401_RS09040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ptc2401_RS09050	COG0772	Belongs to the SEDS family
Ptc2401_RS09055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ptc2401_RS09065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Ptc2401_RS09070	COG0012	GTP binding
Ptc2401_RS09075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Ptc2401_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
Ptc2401_RS09090	COG1850	ribulose-bisphosphate carboxylase activity
Ptc2401_RS09095	COG1830	Aldolase
Ptc2401_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
Ptc2401_RS09100	COG3347	Dehydrogenase
Ptc2401_RS09115	COG1032	radical SAM domain protein
Ptc2401_RS09120	COG2137	regulation of response to DNA damage stimulus
Ptc2401_RS09125	COG0528	UMP kinase activity
Ptc2401_RS09130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ptc2401_RS09135	COG0052	Belongs to the universal ribosomal protein uS2 family
Ptc2401_RS09140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Ptc2401_RS09145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Ptc2401_RS09150	COG1160	GTP binding
Ptc2401_RS09155	COG0489	protein tyrosine kinase activity
Ptc2401_RS09160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Ptc2401_RS09165	COG1674	ftsk spoiiie
Ptc2401_RS09170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Ptc2401_RS09190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ptc2401_RS09195	COG0556	nucleotide-excision repair
Ptc2401_RS09200	COG0612	Peptidase, M16
Ptc2401_RS09225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ptc2401_RS09230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ptc2401_RS09235	COG0525	valine-tRNA ligase activity
Ptc2401_RS09240	COG0740	serine-type endopeptidase activity
Ptc2401_RS09245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Ptc2401_RS09250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Ptc2401_RS09255	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ptc2401_RS09260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Ptc2401_RS09265	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Ptc2401_RS09275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ptc2401_RS09290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Ptc2401_RS09295	COG1611	Belongs to the LOG family
Ptc2401_RS09300	COG0512	Glutamine amidotransferase of anthranilate synthase
Ptc2401_RS09330	COG2197	response regulator
Ptc2401_RS09335	COG1012	belongs to the aldehyde dehydrogenase family
Ptc2401_RS09340	COG1162	GTPase activity
Ptc2401_RS09345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ptc2401_RS09350	COG0254	rRNA binding
Ptc2401_RS09355	COG0233	cytoplasmic translational termination
Ptc2401_RS09360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ptc2401_RS09370	COG1570	exodeoxyribonuclease VII activity
Ptc2401_RS09375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Ptc2401_RS09380	COG1872	DUF167
Ptc2401_RS09385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ptc2401_RS09390	COG0372	Belongs to the citrate synthase family
Ptc2401_RS09395	COG1115	amino acid carrier protein
Ptc2401_RS09425	COG1169	isochorismate synthase
Ptc2401_RS09430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Ptc2401_RS09435	COG0596	Alpha beta hydrolase
Ptc2401_RS09460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Ptc2401_RS09465	COG1475	DNA binding
Ptc2401_RS09470	COG1192	Involved in chromosome partitioning
Ptc2401_RS09475	COG2094	Belongs to the DNA glycosylase MPG family
Ptc2401_RS09480	COG2239	Acts as a magnesium transporter
Ptc2401_RS09490	COG0482	sulfurtransferase activity
Ptc2401_RS09495	COG0400	carboxylic ester hydrolase activity
Ptc2401_RS09500	COG1410	methionine synthase
Ptc2401_RS09500	COG0646	methionine synthase
Ptc2401_RS09520	COG5634	Uncharacterized conserved protein (DUF2278)
Ptc2401_RS09525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Ptc2401_RS09530	COG0363	glucosamine-6-phosphate deaminase activity
Ptc2401_RS09535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Ptc2401_RS09540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Ptc2401_RS09545	COG5002	protein histidine kinase activity
Ptc2401_RS09545	COG2205	protein histidine kinase activity
Ptc2401_RS09545	COG0784	Response regulator, receiver
Ptc2401_RS09570	COG1012	belongs to the aldehyde dehydrogenase family
Ptc2401_RS09580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ptc2401_RS09590	COG0826	peptidase U32
Ptc2401_RS09595	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Ptc2401_RS09620	COG0589	response to stress
Ptc2401_RS09625	COG4651	solute:proton antiporter activity
Ptc2401_RS09625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ptc2401_RS09630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ptc2401_RS09640	COG0543	2 iron, 2 sulfur cluster binding
Ptc2401_RS09650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Ptc2401_RS09655	COG1047	Peptidyl-prolyl cis-trans
Ptc2401_RS09660	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Ptc2401_RS09660	COG3264	Mechanosensitive ion channel
Ptc2401_RS09670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Ptc2401_RS09680	COG1078	dGTPase activity
Ptc2401_RS09690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Ptc2401_RS09695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Ptc2401_RS09700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Ptc2401_RS09710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ptc2401_RS09715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ptc2401_RS09730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ptc2401_RS09735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ptc2401_RS09740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Ptc2401_RS09750	COG0612	Peptidase, M16
Ptc2401_RS09755	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ptc2401_RS09770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ptc2401_RS09795	COG0003	Pfam Anion-transporting ATPase
Ptc2401_RS09800	COG0543	2 iron, 2 sulfur cluster binding
Ptc2401_RS09805	COG0629	single-stranded DNA binding
Ptc2401_RS09825	COG4771	TonB-dependent receptor
Ptc2401_RS09830	COG1429	ligase activity, forming nitrogen-metal bonds
Ptc2401_RS09840	COG1429	ligase activity, forming nitrogen-metal bonds
Ptc2401_RS09855	COG0071	Belongs to the small heat shock protein (HSP20) family
Ptc2401_RS09865	COG3174	membrane
Ptc2401_RS09880	COG0463	Glycosyl transferase, family 2
Ptc2401_RS09885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Ptc2401_RS09900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ptc2401_RS09905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ptc2401_RS09920	COG1104	cysteine desulfurase activity
Ptc2401_RS09935	COG1253	flavin adenine dinucleotide binding
Ptc2401_RS09940	COG0105	UTP biosynthetic process
Ptc2401_RS09955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Ptc2401_RS09960	COG1040	competence protein
Ptc2401_RS09965	COG1940	carbohydrate kinase activity
Ptc2401_RS09970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ptc2401_RS09980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ptc2401_RS09985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Ptc2401_RS09990	COG0297	glycogen (starch) synthase activity
Ptc2401_RS10010	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Ptc2401_RS10015	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ptc2401_RS10020	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ptc2401_RS10030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Ptc2401_RS10035	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Ptc2401_RS10040	COG0215	cysteine-tRNA ligase activity
Ptc2401_RS10050	COG0357	Ribosomal RNA small subunit methyltransferase G
Ptc2401_RS10055	COG0203	ribosomal protein L17
Ptc2401_RS10060	COG0202	RNA polymerase activity
Ptc2401_RS10065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Ptc2401_RS10070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Ptc2401_RS10075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Ptc2401_RS10080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Ptc2401_RS10095	COG0200	Binds to the 23S rRNA
Ptc2401_RS10100	COG1841	ribosomal large subunit assembly
Ptc2401_RS10105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Ptc2401_RS10110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Ptc2401_RS10115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Ptc2401_RS10120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ptc2401_RS10125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Ptc2401_RS10130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ptc2401_RS10135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Ptc2401_RS10145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Ptc2401_RS10150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Ptc2401_RS10155	COG0255	Belongs to the universal ribosomal protein uL29 family
Ptc2401_RS10160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Ptc2401_RS10165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Ptc2401_RS10170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Ptc2401_RS10175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Ptc2401_RS10180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Ptc2401_RS10185	COG0089	rRNA binding
Ptc2401_RS10190	COG0088	Forms part of the polypeptide exit tunnel
Ptc2401_RS10195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Ptc2401_RS10200	COG0051	transcription antitermination factor activity, RNA binding
Ptc2401_RS10205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ptc2401_RS10210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ptc2401_RS10215	COG0049	tRNA binding
Ptc2401_RS10220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Ptc2401_RS10255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Ptc2401_RS10260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ptc2401_RS10265	COG1722	exodeoxyribonuclease VII activity
Ptc2401_RS10270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ptc2401_RS10280	COG0542	response to heat
Ptc2401_RS10315	COG0714	Associated with various cellular activities
Ptc2401_RS10325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ptc2401_RS10330	COG1862	Preprotein translocase
Ptc2401_RS10335	COG0505	Belongs to the CarA family
Ptc2401_RS10340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Ptc2401_RS10350	COG3245	cytochrome
Ptc2401_RS10365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Ptc2401_RS10380	COG0314	molybdopterin synthase activity
Ptc2401_RS10385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Ptc2401_RS10390	COG0303	'Molybdopterin
Ptc2401_RS10395	COG0315	cyclic pyranopterin monophosphate synthase activity
Ptc2401_RS10395	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ptc2401_RS10400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ptc2401_RS10420	COG0315	cyclic pyranopterin monophosphate synthase activity
Ptc2401_RS10420	COG0746	molybdenum cofactor guanylyltransferase activity
Ptc2401_RS10430	COG2871	sodium ion transport
Ptc2401_RS10435	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Ptc2401_RS10440	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Ptc2401_RS10445	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Ptc2401_RS10450	COG1805	sodium ion transport
Ptc2401_RS10455	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Ptc2401_RS10465	COG0437	4 iron, 4 sulfur cluster binding
Ptc2401_RS10470	COG3301	Polysulphide reductase, NrfD
Ptc2401_RS10505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Ptc2401_RS10510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ptc2401_RS10520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Ptc2401_RS10530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Ptc2401_RS10535	COG0542	response to heat
Ptc2401_RS10545	COG1472	Belongs to the glycosyl hydrolase 3 family
Ptc2401_RS10555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ptc2401_RS10560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ptc2401_RS10565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Ptc2401_RS10570	COG0527	aspartate kinase activity
Ptc2401_RS10575	COG2264	protein methyltransferase activity
Ptc2401_RS10600	COG1538	Outer membrane efflux protein
Ptc2401_RS10605	COG0577	efflux transmembrane transporter activity
Ptc2401_RS10605	COG1136	(ABC) transporter
Ptc2401_RS10620	COG1309	transcriptional regulator
Ptc2401_RS10640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Ptc2401_RS10645	COG4106	trans-aconitate 2-methyltransferase activity
Ptc2401_RS10655	COG0156	8-amino-7-oxononanoate synthase activity
Ptc2401_RS10660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Ptc2401_RS10670	COG0653	protein targeting
Ptc2401_RS10715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ptc2401_RS10720	COG1918	ferrous iron import across plasma membrane
Ptc2401_RS10720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ptc2401_RS10725	COG1918	ferrous iron import across plasma membrane
Ptc2401_RS10730	COG0537	adenosine 5'-monophosphoramidase activity
Ptc2401_RS10760	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Ptc2401_RS10770	COG0180	Tryptophanyl-tRNA synthetase
Ptc2401_RS10780	COG0018	arginyl-trna synthetase
Ptc2401_RS10785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Ptc2401_RS10810	COG4584	PFAM Integrase catalytic
Ptc2401_RS10815	COG1484	DNA-dependent DNA replication
Ptc2401_RS10820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ptc2401_RS10845	COG0732	type I restriction modification DNA specificity domain
Ptc2401_RS10855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ptc2401_RS10875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ptc2401_RS10880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ptc2401_RS10885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ptc2401_RS10890	COG0356	it plays a direct role in the translocation of protons across the membrane
Ptc2401_RS10905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Ptc2401_RS10910	COG1496	oxidoreductase activity
Ptc2401_RS10920	COG2813	Specifically methylates the guanine in position
Ptc2401_RS10925	COG0427	acetyl-CoA hydrolase
Ptc2401_RS10930	COG1053	succinate dehydrogenase
Ptc2401_RS10945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Ptc2401_RS10960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Ptc2401_RS10965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ptc2401_RS10970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ptc2401_RS10975	COG0772	Belongs to the SEDS family
Ptc2401_RS10980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Ptc2401_RS10985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ptc2401_RS10990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Ptc2401_RS10995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ptc2401_RS11010	COG0275	rRNA processing
Ptc2401_RS11015	COG2001	Belongs to the MraZ family
Ptc2401_RS11030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Ptc2401_RS11035	COG0126	phosphoglycerate kinase activity
Ptc2401_RS11040	COG0457	Tetratricopeptide repeat
Ptc2401_RS11040	COG0705	Rhomboid family
Ptc2401_RS11050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ptc2401_RS11055	COG0671	phosphoesterase, PA-phosphatase related
Ptc2401_RS11060	COG0706	membrane insertase activity
Ptc2401_RS11065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Ptc2401_RS11070	COG0594	ribonuclease P activity
Ptc2401_RS11075	COG0230	Belongs to the bacterial ribosomal protein bL34 family