locus-tag	class	description
GSM99_RS00005	COG3539	Fimbrial protein
GSM99_RS00010	COG3188	usher protein
GSM99_RS00015	COG3121	Chaperone
GSM99_RS00020	COG3539	Fimbrial protein
GSM99_RS00025	COG3539	Fimbrial protein
GSM99_RS00030	COG0590	tRNA wobble adenosine to inosine editing
GSM99_RS00035	COG1280	lysine exporter protein (LysE YggA)
GSM99_RS00040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GSM99_RS00045	COG0736	holo-[acyl-carrier-protein] synthase activity
GSM99_RS00050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GSM99_RS00055	COG1381	Involved in DNA repair and RecF pathway recombination
GSM99_RS00060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSM99_RS00065	COG0571	ribonuclease III activity
GSM99_RS00070	COG0681	Belongs to the peptidase S26 family
GSM99_RS00075	COG0481	GTPase activity
GSM99_RS00095	COG1595	DNA-templated transcription, initiation
GSM99_RS00100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GSM99_RS00110	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GSM99_RS00115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GSM99_RS00125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GSM99_RS00140	COG2914	Belongs to the UPF0125 (RnfH) family
GSM99_RS00145	COG2867	negative regulation of translational initiation
GSM99_RS00150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GSM99_RS00255	COG0740	serine-type endopeptidase activity
GSM99_RS00260	COG4695	Portal protein
GSM99_RS00265	COG1802	Transcriptional regulator
GSM99_RS00265	COG4626	Terminase
GSM99_RS00330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GSM99_RS00445	COG0582	viral genome integration into host DNA
GSM99_RS00460	COG0384	phenazine biosynthesis protein PhzF
GSM99_RS00470	COG0840	transmembrane signaling receptor activity
GSM99_RS00475	COG1620	l-lactate permease
GSM99_RS00480	COG0247	lactate metabolic process
GSM99_RS00485	COG1139	Iron-sulfur cluster binding protein
GSM99_RS00490	COG1556	Lactate utilization protein
GSM99_RS00510	COG3738	Protein conserved in bacteria
GSM99_RS00525	COG4771	TonB-dependent receptor
GSM99_RS00535	COG1609	Transcriptional regulator
GSM99_RS00540	COG2017	converts alpha-aldose to the beta-anomer
GSM99_RS00550	COG1085	galactose-1-phosphate uridylyltransferase
GSM99_RS00555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GSM99_RS00565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSM99_RS00570	COG0589	response to stress
GSM99_RS00575	COG4574	serine-type endopeptidase inhibitor activity
GSM99_RS00580	COG2841	Protein conserved in bacteria
GSM99_RS00655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GSM99_RS00665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GSM99_RS00670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GSM99_RS00680	COG0716	FMN binding
GSM99_RS00690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GSM99_RS00695	COG0354	folic acid binding
GSM99_RS00705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSM99_RS00705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSM99_RS00710	COG0509	glycine decarboxylation via glycine cleavage system
GSM99_RS00715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSM99_RS00720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSM99_RS00725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSM99_RS00730	COG0006	proline dipeptidase activity
GSM99_RS00735	COG3079	Belongs to the UPF0149 family
GSM99_RS00740	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GSM99_RS00765	COG2274	protein secretion by the type I secretion system
GSM99_RS00770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSM99_RS00775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GSM99_RS00790	COG1279	arginine transmembrane transporter activity
GSM99_RS00800	COG3112	Uncharacterised protein family (UPF0231)
GSM99_RS00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSM99_RS00825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GSM99_RS00830	COG2186	Transcriptional regulator
GSM99_RS00835	COG3023	N-Acetylmuramoyl-L-alanine amidase
GSM99_RS00840	COG4969	Belongs to the N-Me-Phe pilin family
GSM99_RS00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GSM99_RS00850	COG1459	type II secretion system
GSM99_RS00855	COG0237	dephospho-CoA kinase activity
GSM99_RS00860	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GSM99_RS00865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GSM99_RS00875	COG0814	amino acid
GSM99_RS00880	COG3033	Beta-eliminating lyase
GSM99_RS00905	COG0789	Transcriptional regulator
GSM99_RS00910	COG0653	protein targeting
GSM99_RS00925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GSM99_RS00935	COG0849	cell division
GSM99_RS00940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GSM99_RS00950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSM99_RS00955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSM99_RS00960	COG0772	Belongs to the SEDS family
GSM99_RS00965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GSM99_RS00970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSM99_RS00975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GSM99_RS00980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GSM99_RS00985	COG0768	penicillin binding
GSM99_RS00995	COG0275	rRNA processing
GSM99_RS01000	COG2001	Belongs to the MraZ family
GSM99_RS01005	COG1609	Transcriptional regulator
GSM99_RS01010	COG1022	Amp-dependent synthetase and ligase
GSM99_RS01020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSM99_RS01025	COG0473	3-isopropylmalate dehydrogenase activity
GSM99_RS01030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GSM99_RS01045	COG3066	DNA modification
GSM99_RS01050	COG0010	Belongs to the arginase family
GSM99_RS01055	COG1166	arginine decarboxylase activity
GSM99_RS01060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GSM99_RS01065	COG2194	sulfuric ester hydrolase activity
GSM99_RS01100	COG1215	transferase activity, transferring glycosyl groups
GSM99_RS01105	COG1215	transferase activity, transferring glycosyl groups
GSM99_RS01110	COG0457	Tetratricopeptide repeat
GSM99_RS01110	COG3118	belongs to the thioredoxin family
GSM99_RS01125	COG0640	Transcriptional regulator
GSM99_RS01130	COG3091	SprT-like family
GSM99_RS01135	COG2239	Acts as a magnesium transporter
GSM99_RS01145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSM99_RS01150	COG1151	hydroxylamine reductase activity
GSM99_RS01160	COG1115	amino acid carrier protein
GSM99_RS01175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSM99_RS01185	COG2353	YceI-like domain
GSM99_RS01190	COG3038	cytochrome b561
GSM99_RS01210	COG3119	arylsulfatase activity
GSM99_RS01235	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GSM99_RS01255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSM99_RS01255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSM99_RS01260	COG3716	PTS system mannose fructose sorbose family IID component
GSM99_RS01265	COG3715	PTS system
GSM99_RS01270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSM99_RS01285	COG1349	DNA-binding transcription factor activity
GSM99_RS01310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSM99_RS01315	COG0800	Aldolase
GSM99_RS01575	COG0582	viral genome integration into host DNA
GSM99_RS01585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSM99_RS01590	COG2501	S4 domain
GSM99_RS01595	COG1105	Belongs to the carbohydrate kinase PfkB family
GSM99_RS01605	COG0215	cysteine-tRNA ligase activity
GSM99_RS01610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GSM99_RS01615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSM99_RS01635	COG0668	transmembrane transport
GSM99_RS01645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GSM99_RS01650	COG4181	ATPase activity
GSM99_RS01655	COG2755	lipolytic protein G-D-S-L family
GSM99_RS01660	COG0300	oxidoreductase activity
GSM99_RS01665	COG3118	belongs to the thioredoxin family
GSM99_RS01670	COG0330	HflC and HflK could
GSM99_RS01680	COG0789	Transcriptional regulator
GSM99_RS01695	COG3735	TraB family
GSM99_RS01705	COG0737	Belongs to the 5'-nucleotidase family
GSM99_RS01710	COG2223	nitrite transmembrane transporter activity
GSM99_RS01715	COG4651	solute:proton antiporter activity
GSM99_RS01715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSM99_RS01720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSM99_RS01725	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GSM99_RS01730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GSM99_RS01735	COG0563	adenylate kinase activity
GSM99_RS01740	COG0326	Molecular chaperone. Has ATPase activity
GSM99_RS01745	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GSM99_RS01750	COG2962	Rard protein
GSM99_RS01785	COG4589	Belongs to the CDS family
GSM99_RS01795	COG0583	DNA-binding transcription factor activity
GSM99_RS01805	COG0549	Belongs to the carbamate kinase family
GSM99_RS01815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GSM99_RS01820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GSM99_RS01825	COG2353	YceI-like domain
GSM99_RS01845	COG0471	metal ion transport
GSM99_RS01855	COG3539	Fimbrial protein
GSM99_RS01870	COG3539	Fimbrial protein
GSM99_RS01895	COG0471	metal ion transport
GSM99_RS01900	COG0583	DNA-binding transcription factor activity
GSM99_RS01960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GSM99_RS01980	COG1388	LysM domain
GSM99_RS01980	COG4942	peptidase
GSM99_RS01985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GSM99_RS01990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GSM99_RS01995	COG0585	pseudouridine synthase activity
GSM99_RS02000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GSM99_RS02005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GSM99_RS02015	COG0529	Catalyzes the synthesis of activated sulfate
GSM99_RS02020	COG2895	sulfate adenylyltransferase (ATP) activity
GSM99_RS02025	COG0175	sulfate reduction
GSM99_RS02030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSM99_RS02030	COG1648	precorrin-2 dehydrogenase activity
GSM99_RS02035	COG0175	sulfate reduction
GSM99_RS02040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSM99_RS02045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GSM99_RS02050	COG0720	synthase
GSM99_RS02080	COG3021	interspecies interaction between organisms
GSM99_RS02110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GSM99_RS02115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GSM99_RS02120	COG2011	ABC-type metal ion transport system permease component
GSM99_RS02135	COG1720	tRNA m6t6A37 methyltransferase activity
GSM99_RS02150	COG4568	rho-dependent transcription termination
GSM99_RS02155	COG0037	tRNA processing
GSM99_RS02170	COG0825	malonyl-CoA metabolic process
GSM99_RS02180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSM99_RS02190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSM99_RS02195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSM99_RS02200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSM99_RS02210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSM99_RS02220	COG0575	Belongs to the CDS family
GSM99_RS02225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSM99_RS02230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GSM99_RS02235	COG0233	cytoplasmic translational termination
GSM99_RS02240	COG0528	UMP kinase activity
GSM99_RS02245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GSM99_RS02255	COG0024	Methionine aminopeptidase
GSM99_RS02260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GSM99_RS02265	COG2171	N-acyltransferase activity
GSM99_RS02290	COG0564	pseudouridine synthase activity
GSM99_RS02305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GSM99_RS02305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GSM99_RS02315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSM99_RS02325	COG2363	Small membrane protein
GSM99_RS02330	COG0583	DNA-binding transcription factor activity
GSM99_RS02335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSM99_RS02340	COG2166	iron-sulfur cluster assembly
GSM99_RS02370	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSM99_RS02375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GSM99_RS02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GSM99_RS02380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GSM99_RS02385	COG1074	ATP-dependent DNA helicase activity
GSM99_RS02390	COG1025	Belongs to the peptidase M16 family
GSM99_RS02395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GSM99_RS02420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GSM99_RS02425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GSM99_RS02435	COG0494	nUDIX hydrolase
GSM99_RS02445	COG1178	ABC-type Fe3 transport system permease component
GSM99_RS02450	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GSM99_RS02455	COG0417	DNA replication proofreading
GSM99_RS02465	COG0564	pseudouridine synthase activity
GSM99_RS02470	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GSM99_RS02475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GSM99_RS02480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSM99_RS02485	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GSM99_RS02490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GSM99_RS02495	COG2967	ApaG domain
GSM99_RS02500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSM99_RS02505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GSM99_RS02510	COG1280	lysine exporter protein (LysE YggA)
GSM99_RS02525	COG2132	Multicopper oxidase
GSM99_RS02530	COG0204	Acyl-transferase
GSM99_RS02535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSM99_RS02540	COG0187	DNA topoisomerase II activity
GSM99_RS02545	COG3150	esterase
GSM99_RS02550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GSM99_RS02555	COG0494	nUDIX hydrolase
GSM99_RS02560	COG1538	Outer membrane efflux protein
GSM99_RS02565	COG5463	Belongs to the UPF0441 family
GSM99_RS02570	COG0754	glutathionylspermidine amidase activity
GSM99_RS02575	COG3384	dioxygenase
GSM99_RS02580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSM99_RS02600	COG2188	Transcriptional regulator
GSM99_RS02610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GSM99_RS02625	COG0617	tRNA 3'-terminal CCA addition
GSM99_RS02630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GSM99_RS02635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GSM99_RS02640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GSM99_RS02650	COG0358	DNA primase activity
GSM99_RS02655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSM99_RS02680	COG0840	transmembrane signaling receptor activity
GSM99_RS02685	COG1396	sequence-specific DNA binding
GSM99_RS02690	COG3539	Fimbrial protein
GSM99_RS02695	COG3121	Chaperone
GSM99_RS02710	COG0560	Phosphoserine phosphatase
GSM99_RS02775	COG4245	von Willebrand factor, type A
GSM99_RS02805	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GSM99_RS02855	COG2376	Dihydroxyacetone kinase
GSM99_RS02860	COG1461	Dihydroxyacetone kinase
GSM99_RS02890	COG3121	Chaperone
GSM99_RS02895	COG3188	usher protein
GSM99_RS02920	COG2271	Major facilitator Superfamily
GSM99_RS02925	COG0469	pyruvate kinase activity
GSM99_RS02950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSM99_RS02965	COG0813	purine-nucleoside phosphorylase activity
GSM99_RS02970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GSM99_RS02975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GSM99_RS02980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GSM99_RS02985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSM99_RS02990	COG0084	hydrolase, TatD family'
GSM99_RS03005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GSM99_RS03020	COG2813	Specifically methylates the guanine in position
GSM99_RS03055	COG2382	esterase
GSM99_RS03075	COG0560	Phosphoserine phosphatase
GSM99_RS03080	COG3726	membrane protein affecting hemolysin expression
GSM99_RS03085	COG1328	CTP reductase activity
GSM99_RS03090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSM99_RS03100	COG1124	(ABC) transporter
GSM99_RS03110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSM99_RS03125	COG1216	Glycosyl transferase, family 2
GSM99_RS03140	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GSM99_RS03150	COG3260	NADH ubiquinone oxidoreductase 20
GSM99_RS03155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSM99_RS03160	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GSM99_RS03160	COG3261	NADH dehydrogenase
GSM99_RS03165	COG0651	ATP synthesis coupled electron transport
GSM99_RS03170	COG4237	Hydrogenase 4 membrane
GSM99_RS03175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSM99_RS03180	COG0650	Formate hydrogenlyase subunit 4
GSM99_RS03185	COG0651	ATP synthesis coupled electron transport
GSM99_RS03190	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GSM99_RS03200	COG0698	ribose 5-phosphate isomerase
GSM99_RS03205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSM99_RS03220	COG0025	NhaP-type Na H and K H
GSM99_RS03225	COG0459	protein refolding
GSM99_RS03230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GSM99_RS03240	COG1027	Aspartate ammonia-lyase
GSM99_RS03245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GSM99_RS03250	COG1309	transcriptional regulator
GSM99_RS03260	COG2002	toxin-antitoxin pair type II binding
GSM99_RS03290	COG4977	sequence-specific DNA binding
GSM99_RS03295	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GSM99_RS03300	COG0644	oxidoreductase
GSM99_RS03305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GSM99_RS03310	COG2086	electron transfer activity
GSM99_RS03315	COG1960	acyl-CoA dehydrogenase activity
GSM99_RS03320	COG2610	gluconate transmembrane transporter activity
GSM99_RS03335	COG1924	4 iron, 4 sulfur cluster binding
GSM99_RS03345	COG0318	PFAM AMP-dependent synthetase and ligase
GSM99_RS03350	COG2271	Major facilitator Superfamily
GSM99_RS03355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GSM99_RS03360	COG0644	oxidoreductase
GSM99_RS03380	COG1960	acyl-CoA dehydrogenase activity
GSM99_RS03385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSM99_RS03390	COG0318	PFAM AMP-dependent synthetase and ligase
GSM99_RS03395	COG1024	Enoyl-CoA hydratase
GSM99_RS03410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSM99_RS03415	COG3397	chitin binding
GSM99_RS03470	COG0583	DNA-binding transcription factor activity
GSM99_RS03475	COG2137	regulation of response to DNA damage stimulus
GSM99_RS03495	COG2992	FlgJ-related protein
GSM99_RS03515	COG0840	transmembrane signaling receptor activity
GSM99_RS03525	COG3265	gluconokinase activity
GSM99_RS03545	COG1120	ATPase activity
GSM99_RS03550	COG0500	methyltransferase
GSM99_RS03555	COG0157	Belongs to the NadC ModD family
GSM99_RS03640	COG1157	protein secretion by the type III secretion system
GSM99_RS03650	COG4789	Type iii secretion
GSM99_RS03665	COG2207	Transcriptional regulator
GSM99_RS03705	COG0789	Transcriptional regulator
GSM99_RS03715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSM99_RS03720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSM99_RS03725	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GSM99_RS03750	COG4869	propanediol catabolic process
GSM99_RS03755	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSM99_RS03760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSM99_RS03765	COG1882	Formate acetyltransferase
GSM99_RS03775	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GSM99_RS03780	COG1454	alcohol dehydrogenase
GSM99_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
GSM99_RS03785	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSM99_RS03790	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSM99_RS03795	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSM99_RS03845	COG3539	Fimbrial protein
GSM99_RS03855	COG1396	sequence-specific DNA binding
GSM99_RS03860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GSM99_RS03865	COG1177	transmembrane transport
GSM99_RS03870	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSM99_RS03885	COG3196	Protein conserved in bacteria
GSM99_RS03890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSM99_RS03900	COG0305	Participates in initiation and elongation during chromosome replication
GSM99_RS03905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSM99_RS03910	COG1448	Aminotransferase
GSM99_RS03920	COG0814	amino acid
GSM99_RS03935	COG0735	belongs to the Fur family
GSM99_RS03950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSM99_RS03955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GSM99_RS03960	COG2937	Belongs to the GPAT DAPAT family
GSM99_RS03965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GSM99_RS03970	COG3161	chorismate lyase activity
GSM99_RS03975	COG0166	Belongs to the GPI family
GSM99_RS04005	COG0129	dihydroxy-acid dehydratase activity
GSM99_RS04010	COG0800	Aldolase
GSM99_RS04020	COG2224	Isocitrate lyase
GSM99_RS04025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GSM99_RS04030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GSM99_RS04040	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSM99_RS04045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GSM99_RS04075	COG0138	bifunctional purine biosynthesis protein purh
GSM99_RS04080	COG0151	Belongs to the GarS family
GSM99_RS04090	COG0776	regulation of translation
GSM99_RS04095	COG3068	Protein conserved in bacteria
GSM99_RS04100	COG1515	deoxyribonuclease V activity
GSM99_RS04105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GSM99_RS04110	COG2816	NAD+ diphosphatase activity
GSM99_RS04120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GSM99_RS04125	COG0352	thiamine-phosphate diphosphorylase activity
GSM99_RS04130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSM99_RS04135	COG2104	thiamine diphosphate biosynthetic process
GSM99_RS04150	COG5464	transposase or invertase
GSM99_RS04155	COG0726	polysaccharide deacetylase
GSM99_RS04160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GSM99_RS04170	COG0222	ribosome binding
GSM99_RS04175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GSM99_RS04180	COG0081	regulation of translation
GSM99_RS04185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GSM99_RS04190	COG0250	Participates in transcription elongation, termination and antitermination
GSM99_RS04195	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSM99_RS04205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSM99_RS04210	COG0049	tRNA binding
GSM99_RS04215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GSM99_RS04225	COG2923	Belongs to the DsrF TusC family
GSM99_RS04230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GSM99_RS04235	COG2964	Protein conserved in bacteria
GSM99_RS04250	COG0545	Peptidyl-prolyl cis-trans isomerase
GSM99_RS04255	COG2900	Belongs to the SlyX family
GSM99_RS04260	COG1047	Peptidyl-prolyl cis-trans
GSM99_RS04265	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GSM99_RS04290	COG0840	transmembrane signaling receptor activity
GSM99_RS04295	COG0840	transmembrane signaling receptor activity
GSM99_RS04315	COG3089	Belongs to the UPF0270 family
GSM99_RS04320	COG3954	Phosphoribulokinase
GSM99_RS04325	COG1765	OsmC-like protein
GSM99_RS04330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSM99_RS04335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSM99_RS04345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GSM99_RS04355	COG0242	peptide deformylase activity
GSM99_RS04365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSM99_RS04365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSM99_RS04370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GSM99_RS04375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSM99_RS04380	COG3084	Protein conserved in bacteria
GSM99_RS04385	COG0746	molybdenum cofactor guanylyltransferase activity
GSM99_RS04390	COG1763	Mo-molybdopterin cofactor biosynthetic process
GSM99_RS04395	COG0366	Alpha amylase catalytic
GSM99_RS04400	COG1609	Transcriptional regulator
GSM99_RS04410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSM99_RS04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSM99_RS04420	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GSM99_RS04430	COG1295	ribonuclease BN
GSM99_RS04435	COG1942	4-Oxalocrotonate Tautomerase
GSM99_RS04455	COG2200	EAL domain
GSM99_RS04455	COG2199	diguanylate cyclase activity
GSM99_RS04460	COG4608	Belongs to the ABC transporter superfamily
GSM99_RS04465	COG0444	Belongs to the ABC transporter superfamily
GSM99_RS04470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSM99_RS04475	COG0601	transmembrane transport
GSM99_RS04480	COG0747	negative chemotaxis
GSM99_RS04495	COG5645	(Lipo)protein
GSM99_RS04505	COG3977	Valine--pyruvate aminotransferase
GSM99_RS04510	COG2818	Glycosylase
GSM99_RS04515	COG0752	glycyl-tRNA synthetase alpha subunit
GSM99_RS04520	COG0751	glycine-tRNA ligase activity
GSM99_RS04540	COG0823	Involved in the tonB-independent uptake of proteins
GSM99_RS04545	COG2860	membrane
GSM99_RS04550	COG0194	GDP metabolic process
GSM99_RS04555	COG1758	RNA polymerase activity
GSM99_RS04560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSM99_RS04565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSM99_RS04570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GSM99_RS04575	COG0786	glutamate:sodium symporter activity
GSM99_RS04580	COG2233	PERMEase
GSM99_RS04585	COG2982	Protein involved in outer membrane biogenesis
GSM99_RS04600	COG0456	acetyltransferase
GSM99_RS04605	COG1490	D-aminoacyl-tRNA deacylase activity
GSM99_RS04635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSM99_RS04655	COG2183	response to ionizing radiation
GSM99_RS04660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSM99_RS04665	COG0745	RESPONSE REGULATOR receiver
GSM99_RS04670	COG2205	protein histidine kinase activity
GSM99_RS04675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GSM99_RS04680	COG0573	inorganic phosphate transmembrane transporter activity
GSM99_RS04685	COG0581	inorganic phosphate transmembrane transporter activity
GSM99_RS04695	COG0704	Plays a role in the regulation of phosphate uptake
GSM99_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSM99_RS04705	COG0765	amino acid transport
GSM99_RS04715	COG2161	toxin-antitoxin pair type II binding
GSM99_RS04720	COG4115	mRNA cleavage
GSM99_RS04725	COG2252	PERMEase
GSM99_RS04735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSM99_RS04745	COG3078	GTPase activator activity
GSM99_RS04755	COG1918	ferrous iron import across plasma membrane
GSM99_RS04780	COG2267	carboxylic ester hydrolase activity
GSM99_RS04790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GSM99_RS04790	COG0316	Belongs to the HesB IscA family
GSM99_RS04795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSM99_RS04800	COG0705	Rhomboid family
GSM99_RS04805	COG1349	DNA-binding transcription factor activity
GSM99_RS04810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSM99_RS04815	COG3189	MarR family transcriptional regulator
GSM99_RS04830	COG3177	Filamentation induced by cAMP protein fic
GSM99_RS04860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSM99_RS04880	COG1124	(ABC) transporter
GSM99_RS04890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSM99_RS04895	COG0601	transmembrane transport
GSM99_RS04900	COG0747	negative chemotaxis
GSM99_RS04905	COG1073	alpha beta
GSM99_RS04905	COG2226	methyltransferase
GSM99_RS04940	COG1136	(ABC) transporter
GSM99_RS04950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GSM99_RS04975	COG3394	polysaccharide catabolic process
GSM99_RS04980	COG1486	melibiose metabolic process
GSM99_RS04985	COG2169	Transcriptional regulator
GSM99_RS04985	COG1917	Cupin 2, conserved barrel domain protein
GSM99_RS04990	COG1447	Phosphotransferase system cellobiose-specific component IIA
GSM99_RS04995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSM99_RS05000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSM99_RS05005	COG4607	ABC-type enterochelin transport system periplasmic component
GSM99_RS05010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSM99_RS05015	COG4605	iron ion homeostasis
GSM99_RS05020	COG4604	ABC transporter, ATP-binding protein
GSM99_RS05045	COG0243	molybdopterin cofactor binding
GSM99_RS05050	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS05055	COG3302	dmso reductase anchor subunit
GSM99_RS05060	COG3381	protein complex oligomerization
GSM99_RS05095	COG2211	Major facilitator Superfamily
GSM99_RS05100	COG1285	pathogenesis
GSM99_RS05130	COG1737	Transcriptional regulator
GSM99_RS05135	COG2731	YhcH YjgK YiaL family protein
GSM99_RS05140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSM99_RS05150	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GSM99_RS05155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GSM99_RS05165	COG0243	molybdopterin cofactor binding
GSM99_RS05165	COG3383	formate dehydrogenase (NAD+) activity
GSM99_RS05170	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS05175	COG2864	formate dehydrogenase
GSM99_RS05180	COG3383	formate dehydrogenase (NAD+) activity
GSM99_RS05185	COG0733	neurotransmitter:sodium symporter activity
GSM99_RS05190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GSM99_RS05195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSM99_RS05195	COG1263	PTS System
GSM99_RS05210	COG0564	pseudouridine synthase activity
GSM99_RS05225	COG1403	HNH endonuclease
GSM99_RS05255	COG0589	response to stress
GSM99_RS05265	COG0306	phosphate transporter
GSM99_RS05270	COG2081	HI0933 family
GSM99_RS05275	COG1741	Belongs to the pirin family
GSM99_RS05280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GSM99_RS05285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GSM99_RS05290	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GSM99_RS05300	COG0494	nUDIX hydrolase
GSM99_RS05305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GSM99_RS05325	COG4796	Type ii and iii secretion system protein
GSM99_RS05330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSM99_RS05335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSM99_RS05350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GSM99_RS05355	COG0546	phosphoglycolate phosphatase activity
GSM99_RS05360	COG0180	Tryptophanyl-tRNA synthetase
GSM99_RS05365	COG2258	MOSC domain
GSM99_RS05370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSM99_RS05375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSM99_RS05380	COG3162	membrane
GSM99_RS05385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSM99_RS05420	COG2186	Transcriptional regulator
GSM99_RS05425	COG0477	Major facilitator Superfamily
GSM99_RS05430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSM99_RS05435	COG0714	Associated with various cellular activities
GSM99_RS05440	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GSM99_RS05445	COG2502	aspartate--ammonia ligase
GSM99_RS05450	COG1522	sequence-specific DNA binding
GSM99_RS05455	COG0716	FMN binding
GSM99_RS05460	COG0445	tRNA wobble uridine modification
GSM99_RS05465	COG0357	Ribosomal RNA small subunit methyltransferase G
GSM99_RS05470	COG3312	ion transport
GSM99_RS05475	COG0356	it plays a direct role in the translocation of protons across the membrane
GSM99_RS05510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GSM99_RS05515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GSM99_RS05520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSM99_RS05610	COG1288	antiporter activity
GSM99_RS05635	COG3111	PFAM Bacterial OB fold (BOF) protein
GSM99_RS05640	COG1584	GPR1 FUN34 yaaH family protein
GSM99_RS05650	COG1940	carbohydrate kinase activity
GSM99_RS05675	COG0457	Tetratricopeptide repeat
GSM99_RS05685	COG3706	GGDEF domain
GSM99_RS05695	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GSM99_RS05705	COG1368	sulfuric ester hydrolase activity
GSM99_RS05710	COG3276	selenocysteine insertion sequence binding
GSM99_RS05715	COG1921	L-seryl-tRNASec selenium transferase activity
GSM99_RS05720	COG3058	Necessary for formate dehydrogenase activity
GSM99_RS05725	COG2864	formate dehydrogenase
GSM99_RS05730	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS05740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GSM99_RS05765	COG0583	DNA-binding transcription factor activity
GSM99_RS05800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GSM99_RS05805	COG0706	membrane insertase activity
GSM99_RS05810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GSM99_RS05815	COG0594	ribonuclease P activity
GSM99_RS05820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GSM99_RS05835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GSM99_RS05845	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSM99_RS05855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GSM99_RS05880	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GSM99_RS05885	COG1561	YicC-like family, N-terminal region
GSM99_RS05890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GSM99_RS05895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GSM99_RS05900	COG1309	transcriptional regulator
GSM99_RS05905	COG0756	dUTP diphosphatase activity
GSM99_RS05910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GSM99_RS05915	COG2003	Belongs to the UPF0758 family
GSM99_RS05920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GSM99_RS05925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSM99_RS05930	COG0438	transferase activity, transferring glycosyl groups
GSM99_RS05940	COG0297	glycogen (starch) synthase activity
GSM99_RS05955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GSM99_RS05960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GSM99_RS05970	COG1519	Transferase
GSM99_RS05975	COG0438	transferase activity, transferring glycosyl groups
GSM99_RS05975	COG0297	glycogen (starch) synthase activity
GSM99_RS05980	COG0438	transferase activity, transferring glycosyl groups
GSM99_RS05985	COG0859	PFAM glycosyl transferase family 9
GSM99_RS05995	COG0859	PFAM glycosyl transferase family 9
GSM99_RS06000	COG0859	PFAM glycosyl transferase family 9
GSM99_RS06010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSM99_RS06020	COG1063	alcohol dehydrogenase
GSM99_RS06025	COG2861	carbohydrate metabolic process
GSM99_RS06030	COG4942	peptidase
GSM99_RS06035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSM99_RS06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSM99_RS06045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GSM99_RS06055	COG1045	serine acetyltransferase
GSM99_RS06060	COG1045	serine acetyltransferase
GSM99_RS06065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GSM99_RS06105	COG0297	glycogen (starch) synthase activity
GSM99_RS06105	COG0438	transferase activity, transferring glycosyl groups
GSM99_RS06135	COG2205	protein histidine kinase activity
GSM99_RS06140	COG0745	RESPONSE REGULATOR receiver
GSM99_RS06145	COG3678	ATP-independent chaperone mediated protein folding
GSM99_RS06150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GSM99_RS06215	COG4695	Portal protein
GSM99_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
GSM99_RS06370	COG0205	6-phosphofructokinase activity
GSM99_RS06375	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GSM99_RS06380	COG0149	triose-phosphate isomerase activity
GSM99_RS06390	COG3152	Membrane
GSM99_RS06395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSM99_RS06400	COG2814	Major facilitator Superfamily
GSM99_RS06405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSM99_RS06415	COG3074	FtsZ-dependent cytokinesis
GSM99_RS06420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GSM99_RS06425	COG1575	Belongs to the MenA family. Type 1 subfamily
GSM99_RS06430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GSM99_RS06435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GSM99_RS06440	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GSM99_RS06445	COG1609	Transcriptional regulator
GSM99_RS06450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GSM99_RS06455	COG0254	rRNA binding
GSM99_RS06460	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GSM99_RS06465	COG0626	cystathionine gamma-synthase activity
GSM99_RS06470	COG0460	homoserine dehydrogenase
GSM99_RS06470	COG0527	aspartate kinase activity
GSM99_RS06475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GSM99_RS06480	COG1216	Glycosyl transferase, family 2
GSM99_RS06485	COG0415	Belongs to the DNA photolyase family
GSM99_RS06495	COG0583	DNA-binding transcription factor activity
GSM99_RS06515	COG0028	Belongs to the TPP enzyme family
GSM99_RS06520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSM99_RS06525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GSM99_RS06530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GSM99_RS06535	COG0137	argininosuccinate synthase activity
GSM99_RS06540	COG0165	Argininosuccinate lyase
GSM99_RS06565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSM99_RS06570	COG4206	TonB-dependent receptor
GSM99_RS06575	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GSM99_RS06610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GSM99_RS06620	COG1072	(Pantothenic acid kinase))
GSM99_RS06650	COG2906	2 iron, 2 sulfur cluster binding
GSM99_RS06660	COG0051	transcription antitermination factor activity, RNA binding
GSM99_RS06665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GSM99_RS06670	COG0088	Forms part of the polypeptide exit tunnel
GSM99_RS06675	COG0089	rRNA binding
GSM99_RS06680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GSM99_RS06685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GSM99_RS06690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GSM99_RS06700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GSM99_RS06705	COG0255	Belongs to the universal ribosomal protein uL29 family
GSM99_RS06710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GSM99_RS06715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GSM99_RS06720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GSM99_RS06725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GSM99_RS06730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSM99_RS06735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GSM99_RS06740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GSM99_RS06745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GSM99_RS06750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GSM99_RS06755	COG1841	ribosomal large subunit assembly
GSM99_RS06760	COG0200	Binds to the 23S rRNA
GSM99_RS06765	COG0201	protein transport
GSM99_RS06770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSM99_RS06775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GSM99_RS06785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSM99_RS06795	COG0203	ribosomal protein L17
GSM99_RS06800	COG0789	Transcriptional regulator
GSM99_RS06805	COG3036	rescue of stalled ribosome
GSM99_RS06810	COG1970	mechanosensitive ion channel activity
GSM99_RS06815	COG0569	domain protein
GSM99_RS06820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GSM99_RS06820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSM99_RS06825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSM99_RS06830	COG0242	peptide deformylase activity
GSM99_RS06835	COG0758	DNA mediated transformation
GSM99_RS06840	COG0551	DNA topoisomerase type I activity
GSM99_RS06845	COG0009	L-threonylcarbamoyladenylate synthase
GSM99_RS06850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSM99_RS06860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GSM99_RS06895	COG0583	DNA-binding transcription factor activity
GSM99_RS06900	COG3085	chromosome segregation
GSM99_RS06905	COG0606	chelatase, subunit chli
GSM99_RS06920	COG3978	acetolactate synthase activity
GSM99_RS06925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSM99_RS06930	COG0129	dihydroxy-acid dehydratase activity
GSM99_RS06940	COG0583	DNA-binding transcription factor activity
GSM99_RS06945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GSM99_RS06955	COG0248	Ppx GppA phosphatase
GSM99_RS06960	COG0513	Belongs to the DEAD box helicase family
GSM99_RS06965	COG3118	belongs to the thioredoxin family
GSM99_RS06970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GSM99_RS06975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSM99_RS06985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSM99_RS06990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GSM99_RS06995	COG1088	dTDP-glucose 4,6-dehydratase activity
GSM99_RS07000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GSM99_RS07010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSM99_RS07015	COG2244	polysaccharide biosynthetic process
GSM99_RS07020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSM99_RS07030	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GSM99_RS07065	COG2959	enzyme of heme biosynthesis
GSM99_RS07075	COG0181	hydroxymethylbilane synthase activity
GSM99_RS07085	COG1965	Belongs to the frataxin family
GSM99_RS07090	COG5567	small periplasmic lipoprotein
GSM99_RS07095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GSM99_RS07110	COG1011	Hydrolase
GSM99_RS07125	COG2962	Rard protein
GSM99_RS07130	COG2050	protein possibly involved in aromatic compounds catabolism
GSM99_RS07145	COG2267	carboxylic ester hydrolase activity
GSM99_RS07150	COG0561	phosphatase activity
GSM99_RS07155	COG3264	Mechanosensitive ion channel
GSM99_RS07155	COG1511	domain protein
GSM99_RS07160	COG0688	phosphatidylethanolamine metabolic process
GSM99_RS07165	COG1162	GTPase activity
GSM99_RS07170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GSM99_RS07190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSM99_RS07195	COG0802	atpase or kinase
GSM99_RS07200	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSM99_RS07210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GSM99_RS07215	COG1923	regulation of RNA biosynthetic process
GSM99_RS07220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSM99_RS07225	COG0330	HflC and HflK could
GSM99_RS07235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GSM99_RS07240	COG1959	2 iron, 2 sulfur cluster binding
GSM99_RS07245	COG0557	exoribonuclease II activity
GSM99_RS07250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSM99_RS07255	COG0360	Binds together with S18 to 16S ribosomal RNA
GSM99_RS07260	COG2965	DNA replication, synthesis of RNA primer
GSM99_RS07270	COG0359	binds to the 23S rRNA
GSM99_RS07285	COG0254	rRNA binding
GSM99_RS07290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSM99_RS07295	COG3443	Belongs to the bacterial solute-binding protein 9 family
GSM99_RS07300	COG1012	belongs to the aldehyde dehydrogenase family
GSM99_RS07305	COG0545	Peptidyl-prolyl cis-trans isomerase
GSM99_RS07315	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GSM99_RS07325	COG1253	flavin adenine dinucleotide binding
GSM99_RS07330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSM99_RS07335	COG0729	surface antigen
GSM99_RS07340	COG2911	Protein conserved in bacteria
GSM99_RS07345	COG2105	PFAM AIG2 family protein
GSM99_RS07355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GSM99_RS07360	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GSM99_RS07365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSM99_RS07370	COG1438	arginine binding
GSM99_RS07375	COG0039	L-malate dehydrogenase activity
GSM99_RS07380	COG3423	Transcriptional regulator
GSM99_RS07395	COG0142	geranyltranstransferase activity
GSM99_RS07400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GSM99_RS07405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GSM99_RS07410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GSM99_RS07415	COG2027	D-alanyl-D-alanine carboxypeptidase
GSM99_RS07420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSM99_RS07425	COG1534	Rna-binding protein
GSM99_RS07430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GSM99_RS07435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSM99_RS07440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GSM99_RS07445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSM99_RS07450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSM99_RS07465	COG0779	Required for maturation of 30S ribosomal subunits
GSM99_RS07470	COG0195	Participates in both transcription termination and antitermination
GSM99_RS07475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GSM99_RS07480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GSM99_RS07485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GSM99_RS07490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GSM99_RS07495	COG1185	polyribonucleotide nucleotidyltransferase activity
GSM99_RS07505	COG0513	Belongs to the DEAD box helicase family
GSM99_RS07515	COG3275	phosphorelay sensor kinase activity
GSM99_RS07520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSM99_RS07550	COG3153	acetyltransferase
GSM99_RS07555	COG2827	Endonuclease containing a URI domain
GSM99_RS07580	COG0602	queuosine metabolic process
GSM99_RS07590	COG1328	CTP reductase activity
GSM99_RS07595	COG0251	oxidation-reduction process
GSM99_RS07600	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GSM99_RS07605	COG0540	Belongs to the ATCase OTCase family
GSM99_RS07610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSM99_RS07615	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GSM99_RS07630	COG0456	acetyltransferase
GSM99_RS07635	COG0525	valine-tRNA ligase activity
GSM99_RS07640	COG2927	DNA polymerase III (CHI subunit)
GSM99_RS07645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GSM99_RS07650	COG0795	lipopolysaccharide-transporting ATPase activity
GSM99_RS07655	COG0795	lipopolysaccharide-transporting ATPase activity
GSM99_RS07660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSM99_RS07670	COG0582	viral genome integration into host DNA
GSM99_RS07730	COG1086	Polysaccharide biosynthesis protein
GSM99_RS07745	COG0463	Glycosyl transferase, family 2
GSM99_RS07745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSM99_RS07750	COG2244	polysaccharide biosynthetic process
GSM99_RS07755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GSM99_RS07760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GSM99_RS07830	COG0582	viral genome integration into host DNA
GSM99_RS07845	COG3188	usher protein
GSM99_RS07850	COG3121	Chaperone
GSM99_RS07865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GSM99_RS07875	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GSM99_RS07880	COG2271	Major facilitator Superfamily
GSM99_RS07885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GSM99_RS07890	COG1690	Belongs to the RtcB family
GSM99_RS07895	COG1349	DNA-binding transcription factor activity
GSM99_RS07900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GSM99_RS07905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSM99_RS07910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GSM99_RS07915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSM99_RS07915	COG1263	PTS System
GSM99_RS07935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSM99_RS07940	COG0549	Belongs to the carbamate kinase family
GSM99_RS07945	COG1288	antiporter activity
GSM99_RS07955	COG0028	Belongs to the TPP enzyme family
GSM99_RS07960	COG0440	acetolactate synthase activity
GSM99_RS07985	COG2252	PERMEase
GSM99_RS07995	COG0025	NhaP-type Na H and K H
GSM99_RS08000	COG0697	spore germination
GSM99_RS08005	COG0583	DNA-binding transcription factor activity
GSM99_RS08010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GSM99_RS08020	COG3753	Protein conserved in bacteria
GSM99_RS08025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GSM99_RS08035	COG0586	Pfam SNARE associated Golgi protein
GSM99_RS08040	COG1322	Protein conserved in bacteria
GSM99_RS08045	COG2226	methyltransferase
GSM99_RS08050	COG3165	ubiquinone biosynthetic process from chorismate
GSM99_RS08060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSM99_RS08065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSM99_RS08070	COG0805	protein transport
GSM99_RS08085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GSM99_RS08095	COG0183	Belongs to the thiolase family
GSM99_RS08100	COG1024	Enoyl-CoA hydratase
GSM99_RS08100	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSM99_RS08105	COG0006	proline dipeptidase activity
GSM99_RS08110	COG1739	Uncharacterized protein family UPF0029
GSM99_RS08115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GSM99_RS08150	COG1914	H( )-stimulated, divalent metal cation uptake system
GSM99_RS08155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GSM99_RS08165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GSM99_RS08170	COG4770	biotin carboxylase activity
GSM99_RS08175	COG0730	response to heat
GSM99_RS08190	COG0583	DNA-binding transcription factor activity
GSM99_RS08195	COG2197	response regulator
GSM99_RS08200	COG3850	Histidine kinase
GSM99_RS08205	COG2223	nitrite transmembrane transporter activity
GSM99_RS08210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GSM99_RS08215	COG1140	nitrate reductase beta subunit
GSM99_RS08220	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GSM99_RS08225	COG2181	nitrate reductase activity
GSM99_RS08230	COG1335	isochorismatase
GSM99_RS08235	COG1304	FMN binding
GSM99_RS08240	COG2194	sulfuric ester hydrolase activity
GSM99_RS08250	COG2190	(PTS) system
GSM99_RS08250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSM99_RS08250	COG1263	PTS System
GSM99_RS08260	COG1737	Transcriptional regulator
GSM99_RS08275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GSM99_RS08280	COG0375	protein maturation
GSM99_RS08285	COG0298	carbon dioxide binding
GSM99_RS08290	COG2076	Multidrug Resistance protein
GSM99_RS08295	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GSM99_RS08300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GSM99_RS08305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GSM99_RS08310	COG1053	succinate dehydrogenase
GSM99_RS08315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GSM99_RS08340	COG0584	glycerophosphoryl diester phosphodiesterase
GSM99_RS08345	COG2271	Major facilitator Superfamily
GSM99_RS08350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSM99_RS08360	COG0247	lactate metabolic process
GSM99_RS08365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSM99_RS08375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GSM99_RS08380	COG0425	Belongs to the sulfur carrier protein TusA family
GSM99_RS08385	COG2217	Heavy metal translocating P-type atpase
GSM99_RS08390	COG3714	YhhN family
GSM99_RS08400	COG3776	membrane
GSM99_RS08405	COG0742	ribosomal rna small subunit methyltransferase
GSM99_RS08410	COG0552	protein localization to endoplasmic reticulum
GSM99_RS08415	COG2884	Cell division ATP-binding protein ftsE
GSM99_RS08420	COG2177	Part of the ABC transporter FtsEX involved in
GSM99_RS08430	COG1929	Belongs to the glycerate kinase type-1 family
GSM99_RS08435	COG0456	acetyltransferase
GSM99_RS08440	COG2814	Major facilitator Superfamily
GSM99_RS08445	COG1846	Transcriptional regulator
GSM99_RS08455	COG3842	ATPase activity
GSM99_RS08460	COG0395	ABC-type sugar transport system, permease component
GSM99_RS08475	COG0584	glycerophosphoryl diester phosphodiesterase
GSM99_RS08485	COG2807	transmembrane transport
GSM99_RS08525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSM99_RS08530	COG2264	protein methyltransferase activity
GSM99_RS08535	COG4145	pantothenate transmembrane transporter activity
GSM99_RS08540	COG3924	membrane
GSM99_RS08545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GSM99_RS08550	COG0814	amino acid
GSM99_RS08555	COG1522	sequence-specific DNA binding
GSM99_RS08560	COG0439	Biotin carboxylase
GSM99_RS08565	COG0511	ligase activity, forming carbon-carbon bonds
GSM99_RS08570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GSM99_RS08575	COG0604	alcohol dehydrogenase
GSM99_RS08580	COG1077	Cell shape determining protein MreB Mrl
GSM99_RS08585	COG1792	Involved in formation and maintenance of cell shape
GSM99_RS08590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GSM99_RS08595	COG0424	maF-like protein
GSM99_RS08600	COG1530	ribonuclease E activity
GSM99_RS08605	COG3164	Protein of unknown function
GSM99_RS08610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSM99_RS08615	COG0312	modulator of DNA gyrase
GSM99_RS08620	COG4290	ribonuclease
GSM99_RS08630	COG3028	Belongs to the UPF0307 family
GSM99_RS08640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSM99_RS08645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSM99_RS08655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSM99_RS08660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GSM99_RS08675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GSM99_RS08680	COG3117	lipopolysaccharide transmembrane transporter activity
GSM99_RS08690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GSM99_RS08690	COG0517	IMP dehydrogenase activity
GSM99_RS08715	COG2854	intermembrane phospholipid transfer
GSM99_RS08725	COG5007	Belongs to the BolA IbaG family
GSM99_RS08730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSM99_RS08750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSM99_RS08755	COG3105	Protein conserved in bacteria
GSM99_RS08760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GSM99_RS08765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GSM99_RS08770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GSM99_RS08775	COG0625	glutathione transferase activity
GSM99_RS08780	COG2969	positive regulation of protein catabolic process
GSM99_RS08785	COG1473	amidohydrolase
GSM99_RS08790	COG3069	C4-dicarboxylate transmembrane transporter activity
GSM99_RS08795	COG0493	'glutamate synthase
GSM99_RS08800	COG0070	glutamate synthase
GSM99_RS08800	COG0069	glutamate synthase activity
GSM99_RS08800	COG0067	glutamate synthase
GSM99_RS08805	COG5002	protein histidine kinase activity
GSM99_RS08805	COG0784	Response regulator, receiver
GSM99_RS08805	COG2198	Histidine kinase
GSM99_RS08810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GSM99_RS08820	COG2207	Transcriptional regulator
GSM99_RS08830	COG0831	urea catabolic process
GSM99_RS08835	COG0832	Belongs to the urease beta subunit family
GSM99_RS08845	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GSM99_RS08850	COG0830	nickel cation binding
GSM99_RS08855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GSM99_RS08860	COG2823	Periplasmic or secreted lipoprotein
GSM99_RS08865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GSM99_RS08870	COG0792	nuclease activity
GSM99_RS08880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GSM99_RS08890	COG1741	Belongs to the pirin family
GSM99_RS08895	COG0583	DNA-binding transcription factor activity
GSM99_RS08900	COG2259	Doxx family
GSM99_RS08915	COG4575	ribosome binding
GSM99_RS08920	COG0586	Pfam SNARE associated Golgi protein
GSM99_RS08925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GSM99_RS08930	COG1902	pentaerythritol trinitrate reductase activity
GSM99_RS08930	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSM99_RS08945	COG4178	(ABC) transporter
GSM99_RS08950	COG4771	TonB-dependent receptor
GSM99_RS08960	COG1595	DNA-templated transcription, initiation
GSM99_RS08970	COG0488	(ABC) transporter
GSM99_RS08975	COG0741	lytic transglycosylase activity
GSM99_RS08980	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GSM99_RS08985	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GSM99_RS08990	COG0406	alpha-ribazole phosphatase activity
GSM99_RS08995	COG2207	Transcriptional regulator
GSM99_RS08995	COG3708	Transcriptional regulator
GSM99_RS09000	COG3045	CreA protein
GSM99_RS09005	COG0745	RESPONSE REGULATOR receiver
GSM99_RS09015	COG0083	homoserine kinase activity
GSM99_RS09035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSM99_RS09050	COG0443	Heat shock 70 kDa protein
GSM99_RS09055	COG0484	heat shock protein binding
GSM99_RS09065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GSM99_RS09070	COG0583	DNA-binding transcription factor activity
GSM99_RS09075	COG0268	Binds directly to 16S ribosomal RNA
GSM99_RS09085	COG0196	riboflavin kinase activity
GSM99_RS09090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GSM99_RS09095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GSM99_RS09100	COG1047	Peptidyl-prolyl cis-trans
GSM99_RS09110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GSM99_RS09130	COG1470	cell adhesion involved in biofilm formation
GSM99_RS09130	COG1388	LysM domain
GSM99_RS09135	COG0656	L-ascorbic acid biosynthetic process
GSM99_RS09140	COG1979	alcohol dehydrogenase
GSM99_RS09145	COG2226	methyltransferase
GSM99_RS09150	COG0586	Pfam SNARE associated Golgi protein
GSM99_RS09155	COG0626	cystathionine gamma-synthase activity
GSM99_RS09160	COG0811	peptide transport
GSM99_RS09165	COG0848	biopolymer transport protein
GSM99_RS09170	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GSM99_RS09175	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS09180	COG5557	Pfam Polysulphide reductase, NrfD
GSM99_RS09185	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GSM99_RS09190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GSM99_RS09195	COG1773	rubredoxin
GSM99_RS09200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GSM99_RS09205	COG0298	carbon dioxide binding
GSM99_RS09210	COG0409	Hydrogenase expression formation protein
GSM99_RS09215	COG0309	Hydrogenase expression formation protein (HypE)
GSM99_RS09220	COG2391	methyltransferase activity
GSM99_RS09225	COG0425	Belongs to the sulfur carrier protein TusA family
GSM99_RS09230	COG2974	May be involved in recombination
GSM99_RS09240	COG0737	Belongs to the 5'-nucleotidase family
GSM99_RS09245	COG3719	Belongs to the RNase T2 family
GSM99_RS09265	COG0420	3'-5' exonuclease activity
GSM99_RS09290	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GSM99_RS09295	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS09305	COG2414	aldehyde ferredoxin oxidoreductase
GSM99_RS09310	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS09320	COG0450	alkyl hydroperoxide reductase
GSM99_RS09325	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GSM99_RS09330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GSM99_RS09335	COG0343	queuine tRNA-ribosyltransferase activity
GSM99_RS09340	COG1862	Preprotein translocase
GSM99_RS09345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSM99_RS09350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSM99_RS09355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GSM99_RS09365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GSM99_RS09370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSM99_RS09375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GSM99_RS09380	COG2824	Alkylphosphonate utilization operon protein PhnA
GSM99_RS09385	COG1609	Transcriptional regulator
GSM99_RS09390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSM99_RS09395	COG1879	ABC-type sugar transport system periplasmic component
GSM99_RS09400	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSM99_RS09405	COG1129	ABC transporter
GSM99_RS09410	COG1869	D-ribose catabolic process
GSM99_RS09415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GSM99_RS09420	COG0142	geranyltranstransferase activity
GSM99_RS09425	COG1722	exodeoxyribonuclease VII activity
GSM99_RS09430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSM99_RS09430	COG0301	tRNA thio-modification
GSM99_RS09440	COG0693	protein deglycase activity
GSM99_RS09450	COG1666	GTP binding
GSM99_RS09455	COG2814	Major facilitator Superfamily
GSM99_RS09460	COG0109	protoheme IX farnesyltransferase activity
GSM99_RS09465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GSM99_RS09470	COG1845	cytochrome c oxidase, subunit III
GSM99_RS09475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GSM99_RS09480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GSM99_RS09490	COG0513	Belongs to the DEAD box helicase family
GSM99_RS09495	COG2223	nitrite transmembrane transporter activity
GSM99_RS09500	COG3056	Lipoprotein
GSM99_RS09505	COG0271	Belongs to the BolA IbaG family
GSM99_RS09510	COG0544	peptidyl-prolyl cis-trans isomerase activity
GSM99_RS09515	COG0740	serine-type endopeptidase activity
GSM99_RS09520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GSM99_RS09525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GSM99_RS09530	COG0776	regulation of translation
GSM99_RS09535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSM99_RS09540	COG1596	polysaccharide export
GSM99_RS09540	COG1555	photosystem II stabilization
GSM99_RS09545	COG0824	Thioesterase
GSM99_RS09550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GSM99_RS09555	COG1522	sequence-specific DNA binding
GSM99_RS09565	COG1132	(ABC) transporter
GSM99_RS09570	COG0347	Belongs to the P(II) protein family
GSM99_RS09575	COG0004	ammonium transporteR
GSM99_RS09580	COG1946	Acyl-CoA thioesterase
GSM99_RS09600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSM99_RS09605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSM99_RS09610	COG1309	transcriptional regulator
GSM99_RS09615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GSM99_RS09620	COG1196	nuclear chromosome segregation
GSM99_RS09620	COG3264	Mechanosensitive ion channel
GSM99_RS09635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSM99_RS09645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GSM99_RS09650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GSM99_RS09655	COG4245	von Willebrand factor, type A
GSM99_RS09675	COG1966	Carbon starvation protein
GSM99_RS09680	COG2879	small protein
GSM99_RS09685	COG0523	cobalamin synthesis protein
GSM99_RS09695	COG3069	C4-dicarboxylate transmembrane transporter activity
GSM99_RS09700	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSM99_RS09715	COG0534	Mate efflux family protein
GSM99_RS09720	COG0673	inositol 2-dehydrogenase activity
GSM99_RS09725	COG5564	TIM-barrel signal transduction protein
GSM99_RS09730	COG5441	Belongs to the UPF0261 family
GSM99_RS09790	COG2132	Multicopper oxidase
GSM99_RS09795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GSM99_RS09800	COG0288	reversible hydration of carbon dioxide
GSM99_RS09805	COG1131	(ABC) transporter
GSM99_RS09815	COG0477	Major facilitator Superfamily
GSM99_RS09825	COG0501	Belongs to the peptidase M48B family
GSM99_RS09840	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS09855	COG2837	iron assimilation
GSM99_RS09870	COG4633	Protein conserved in bacteria
GSM99_RS09885	COG0754	glutathionylspermidine amidase activity
GSM99_RS09890	COG0583	DNA-binding transcription factor activity
GSM99_RS09895	COG2610	gluconate transmembrane transporter activity
GSM99_RS09900	COG3048	D-serine ammonia-lyase activity
GSM99_RS09915	COG1840	ABC-type Fe3 transport system, periplasmic component
GSM99_RS09935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GSM99_RS09940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GSM99_RS09945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GSM99_RS09955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GSM99_RS09965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSM99_RS09970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSM99_RS09975	COG1489	DNA binding
GSM99_RS09980	COG1643	Atp-dependent helicase
GSM99_RS09985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSM99_RS09990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSM99_RS09995	COG0316	Belongs to the HesB IscA family
GSM99_RS10005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GSM99_RS10015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSM99_RS10020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSM99_RS10025	COG3956	TIGRFAM MazG family protein
GSM99_RS10035	COG0504	CTP synthase activity
GSM99_RS10040	COG0148	phosphopyruvate hydratase activity
GSM99_RS10045	COG0471	metal ion transport
GSM99_RS10050	COG1388	LysM domain
GSM99_RS10050	COG0741	lytic transglycosylase activity
GSM99_RS10055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSM99_RS10060	COG2226	methyltransferase
GSM99_RS10065	COG0328	RNA-DNA hybrid ribonuclease activity
GSM99_RS10070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSM99_RS10100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GSM99_RS10105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSM99_RS10110	COG0126	phosphoglycerate kinase activity
GSM99_RS10130	COG1846	Transcriptional regulator
GSM99_RS10135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSM99_RS10150	COG1234	tRNA 3'-trailer cleavage
GSM99_RS10155	COG4650	regulator
GSM99_RS10165	COG1690	Belongs to the RtcB family
GSM99_RS10170	COG0582	viral genome integration into host DNA
GSM99_RS10175	COG3539	Fimbrial protein
GSM99_RS10205	COG3539	Fimbrial protein
GSM99_RS10220	COG3539	Fimbrial protein
GSM99_RS10230	COG3188	usher protein
GSM99_RS10235	COG3121	Chaperone
GSM99_RS10240	COG3539	Fimbrial protein
GSM99_RS10250	COG3539	Fimbrial protein
GSM99_RS10280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSM99_RS10320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSM99_RS10335	COG0741	lytic transglycosylase activity
GSM99_RS10340	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GSM99_RS10345	COG1194	a g-specific adenine glycosylase
GSM99_RS10355	COG3171	Protein conserved in bacteria
GSM99_RS10360	COG2066	Belongs to the glutaminase family
GSM99_RS10370	COG4607	ABC-type enterochelin transport system periplasmic component
GSM99_RS10375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSM99_RS10380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GSM99_RS10385	COG0762	integral membrane protein
GSM99_RS10390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSM99_RS10395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GSM99_RS10400	COG2805	Type II/IV secretion system protein
GSM99_RS10405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GSM99_RS10410	COG1678	Uncharacterized ACR, COG1678
GSM99_RS10415	COG0189	ligase activity
GSM99_RS10420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GSM99_RS10440	COG0583	DNA-binding transcription factor activity
GSM99_RS10445	COG0583	DNA-binding transcription factor activity
GSM99_RS10450	COG0019	diaminopimelate decarboxylase activity
GSM99_RS10455	COG1960	acyl-CoA dehydrogenase activity
GSM99_RS10460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GSM99_RS10465	COG0121	glutamine amidotransferase
GSM99_RS10470	COG3034	peptidoglycan biosynthetic process
GSM99_RS10475	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GSM99_RS10480	COG1805	sodium ion transport
GSM99_RS10485	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GSM99_RS10490	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GSM99_RS10495	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GSM99_RS10500	COG2871	sodium ion transport
GSM99_RS10505	COG1477	protein flavinylation
GSM99_RS10510	COG2991	Protein conserved in bacteria
GSM99_RS10515	COG3237	CsbD-like
GSM99_RS10525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSM99_RS10530	COG4774	siderophore transport
GSM99_RS10535	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSM99_RS10540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GSM99_RS10555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GSM99_RS10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GSM99_RS10565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSM99_RS10570	COG0318	PFAM AMP-dependent synthetase and ligase
GSM99_RS10570	COG0204	Acyl-transferase
GSM99_RS10575	COG2814	Major facilitator Superfamily
GSM99_RS10580	COG1546	Belongs to the CinA family
GSM99_RS10585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GSM99_RS10590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSM99_RS10595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GSM99_RS10625	COG2918	glutathione biosynthetic process
GSM99_RS10630	COG1854	S-ribosylhomocysteine lyase activity
GSM99_RS10640	COG4536	flavin adenine dinucleotide binding
GSM99_RS10650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GSM99_RS10655	COG0228	four-way junction DNA binding
GSM99_RS10665	COG0336	Belongs to the RNA methyltransferase TrmD family
GSM99_RS10670	COG0335	large ribosomal subunit rRNA binding
GSM99_RS10675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GSM99_RS10680	COG1605	Chorismate mutase
GSM99_RS10680	COG0287	Prephenate dehydrogenase
GSM99_RS10690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GSM99_RS10695	COG0077	Prephenate dehydratase
GSM99_RS10695	COG1605	Chorismate mutase
GSM99_RS10700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GSM99_RS10710	COG0564	pseudouridine synthase activity
GSM99_RS10720	COG0542	response to heat
GSM99_RS10750	COG5544	Lipoprotein
GSM99_RS10755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSM99_RS10770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSM99_RS10775	COG2814	Major facilitator Superfamily
GSM99_RS10780	COG1566	PFAM secretion protein HlyD family protein
GSM99_RS10785	COG1846	Transcriptional regulator
GSM99_RS10790	COG2814	Major facilitator Superfamily
GSM99_RS10800	COG2453	phosphatase
GSM99_RS10800	COG0671	phosphoesterase, PA-phosphatase related
GSM99_RS10805	COG2267	carboxylic ester hydrolase activity
GSM99_RS10825	COG2113	Glycine betaine
GSM99_RS10830	COG4176	ABC-type proline glycine betaine transport system permease component
GSM99_RS10835	COG4175	Glycine betaine
GSM99_RS10845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSM99_RS10850	COG1780	Probably involved in ribonucleotide reductase function
GSM99_RS10860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSM99_RS10865	COG1278	Cold shock
GSM99_RS10870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSM99_RS10875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GSM99_RS10880	COG0321	lipoyl(octanoyl) transferase activity
GSM99_RS10890	COG1686	Belongs to the peptidase S11 family
GSM99_RS10895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GSM99_RS10900	COG0772	Belongs to the SEDS family
GSM99_RS10905	COG0768	penicillin binding
GSM99_RS10910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GSM99_RS10915	COG0799	negative regulation of ribosome biogenesis
GSM99_RS10925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GSM99_RS10930	COG1466	dna polymerase III delta subunit
GSM99_RS10935	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GSM99_RS10940	COG0495	leucyl-tRNA aminoacylation
GSM99_RS10945	COG1126	abc transporter atp-binding protein
GSM99_RS10950	COG0765	amino acid transport
GSM99_RS10955	COG0765	amino acid transport
GSM99_RS10960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSM99_RS10990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GSM99_RS10995	COG4535	Mg2 and Co2 transporter CorC
GSM99_RS11000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GSM99_RS11005	COG1702	phosphate starvation-inducible protein PhoH
GSM99_RS11010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSM99_RS11015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSM99_RS11020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GSM99_RS11070	COG1940	carbohydrate kinase activity
GSM99_RS11070	COG1846	Transcriptional regulator
GSM99_RS11075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GSM99_RS11080	COG0363	glucosamine-6-phosphate deaminase activity
GSM99_RS11090	COG0582	viral genome integration into host DNA
GSM99_RS11195	COG0305	Participates in initiation and elongation during chromosome replication
GSM99_RS11210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSM99_RS11270	COG2369	cell adhesion
GSM99_RS11375	COG0438	transferase activity, transferring glycosyl groups
GSM99_RS11380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSM99_RS11390	COG3739	integral membrane protein
GSM99_RS11395	COG0735	belongs to the Fur family
GSM99_RS11400	COG0716	FMN binding
GSM99_RS11410	COG0596	Alpha beta hydrolase
GSM99_RS11415	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GSM99_RS11420	COG0033	Phosphoglucomutase
GSM99_RS11425	COG4807	Protein conserved in bacteria
GSM99_RS11430	COG3609	addiction module antidote protein, CC2985 family
GSM99_RS11445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GSM99_RS11455	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GSM99_RS11460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GSM99_RS11475	COG2814	Major facilitator Superfamily
GSM99_RS11485	COG0372	Belongs to the citrate synthase family
GSM99_RS11490	COG2009	succinate dehydrogenase
GSM99_RS11495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GSM99_RS11515	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSM99_RS11520	COG0045	succinate-CoA ligase (ADP-forming) activity
GSM99_RS11525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GSM99_RS11530	COG1271	oxidase subunit
GSM99_RS11535	COG1294	oxidase, subunit
GSM99_RS11540	COG4890	Cyd operon protein YbgT
GSM99_RS11545	COG3790	cyd operon protein YbgE
GSM99_RS11550	COG0583	DNA-binding transcription factor activity
GSM99_RS11565	COG0824	Thioesterase
GSM99_RS11570	COG0811	peptide transport
GSM99_RS11575	COG0848	biopolymer transport protein
GSM99_RS11580	COG3064	Membrane
GSM99_RS11585	COG0823	Involved in the tonB-independent uptake of proteins
GSM99_RS11590	COG2885	chlorophyll binding
GSM99_RS11595	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GSM99_RS11620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GSM99_RS11625	COG0588	phosphoglycerate mutase activity
GSM99_RS11630	COG1119	ATPase activity
GSM99_RS11635	COG2831	hemolysin activation secretion protein
GSM99_RS11670	COG3585	molybdate ion transport
GSM99_RS11670	COG2005	Transcriptional regulator
GSM99_RS11680	COG0725	ABC transporter, periplasmic molybdate-binding protein
GSM99_RS11690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GSM99_RS11695	COG0561	phosphatase activity
GSM99_RS11700	COG2706	6-phosphogluconolactonase activity
GSM99_RS11705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSM99_RS11710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSM99_RS11715	COG0156	8-amino-7-oxononanoate synthase activity
GSM99_RS11720	COG2226	methyltransferase
GSM99_RS11730	COG0556	nucleotide-excision repair
GSM99_RS11745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSM99_RS11750	COG0315	cyclic pyranopterin monophosphate synthase activity
GSM99_RS11755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GSM99_RS11760	COG0314	molybdopterin synthase activity
GSM99_RS11765	COG0670	Belongs to the BI1 family
GSM99_RS11770	COG0842	Transport permease protein
GSM99_RS11775	COG0842	Transport permease protein
GSM99_RS11780	COG1131	(ABC) transporter
GSM99_RS11790	COG1309	transcriptional regulator
GSM99_RS11795	COG0513	Belongs to the DEAD box helicase family
GSM99_RS11810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSM99_RS11870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSM99_RS11880	COG2261	transglycosylase associated protein
GSM99_RS11885	COG2897	thiosulfate sulfurtransferase activity
GSM99_RS11895	COG3069	C4-dicarboxylate transmembrane transporter activity
GSM99_RS11915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSM99_RS11920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSM99_RS11925	COG0583	DNA-binding transcription factor activity
GSM99_RS11965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSM99_RS11975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSM99_RS11985	COG0477	Major facilitator Superfamily
GSM99_RS11995	COG2311	Membrane
GSM99_RS12000	COG2949	membrane
GSM99_RS12005	COG0281	malic enzyme
GSM99_RS12010	COG0295	cytidine deaminase activity
GSM99_RS12020	COG1346	cytolysis
GSM99_RS12025	COG1380	Effector of murein hydrolase LrgA
GSM99_RS12030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSM99_RS12030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSM99_RS12035	COG0489	protein tyrosine kinase activity
GSM99_RS12040	COG0572	uridine kinase
GSM99_RS12045	COG0717	Belongs to the dCTP deaminase family
GSM99_RS12050	COG2982	Protein involved in outer membrane biogenesis
GSM99_RS12055	COG3069	C4-dicarboxylate transmembrane transporter activity
GSM99_RS12065	COG1253	flavin adenine dinucleotide binding
GSM99_RS12075	COG1733	regulation of RNA biosynthetic process
GSM99_RS12080	COG0778	Nitroreductase
GSM99_RS12095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GSM99_RS12100	COG1454	alcohol dehydrogenase
GSM99_RS12105	COG0140	phosphoribosyl-ATP diphosphatase activity
GSM99_RS12105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GSM99_RS12110	COG0107	imidazoleglycerol-phosphate synthase activity
GSM99_RS12115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GSM99_RS12120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GSM99_RS12125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GSM99_RS12125	COG0131	Imidazoleglycerol-phosphate dehydratase
GSM99_RS12130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSM99_RS12130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSM99_RS12135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSM99_RS12135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSM99_RS12140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GSM99_RS12145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSM99_RS12150	COG0625	glutathione transferase activity
GSM99_RS12155	COG1686	Belongs to the peptidase S11 family
GSM99_RS12160	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GSM99_RS12165	COG1760	l-serine dehydratase
GSM99_RS12170	COG0814	amino acid
GSM99_RS12175	COG0671	phosphoesterase, PA-phosphatase related
GSM99_RS12180	COG0432	Pfam Uncharacterised protein family UPF0047
GSM99_RS12185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GSM99_RS12200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSM99_RS12210	COG4160	amino acid transport
GSM99_RS12215	COG4215	(ABC) transporter
GSM99_RS12220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSM99_RS12225	COG1126	abc transporter atp-binding protein
GSM99_RS12235	COG2431	L-lysine efflux transmembrane transporter activity
GSM99_RS12245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSM99_RS12250	COG0577	efflux transmembrane transporter activity
GSM99_RS12250	COG1136	(ABC) transporter
GSM99_RS12255	COG1278	Cold shock
GSM99_RS12260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GSM99_RS12265	COG0542	response to heat
GSM99_RS12270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GSM99_RS12275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GSM99_RS12280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GSM99_RS12290	COG0492	ferredoxin-NADP+ reductase activity
GSM99_RS12295	COG1522	sequence-specific DNA binding
GSM99_RS12300	COG3107	peptidoglycan biosynthetic process
GSM99_RS12300	COG1674	ftsk spoiiie
GSM99_RS12305	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GSM99_RS12310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GSM99_RS12315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GSM99_RS12325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GSM99_RS12340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSM99_RS12345	COG1882	Formate acetyltransferase
GSM99_RS12350	COG2116	formate transmembrane transporter activity
GSM99_RS12355	COG1944	ATP diphosphatase activity
GSM99_RS12360	COG0252	asparaginase activity
GSM99_RS12370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GSM99_RS12375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GSM99_RS12380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GSM99_RS12385	COG0539	negative regulation of cytoplasmic translation
GSM99_RS12390	COG0776	regulation of translation
GSM99_RS12395	COG0658	competence protein
GSM99_RS12395	COG2333	competence protein COMEC
GSM99_RS12400	COG1132	(ABC) transporter
GSM99_RS12405	COG1663	tetraacyldisaccharide 4'-kinase activity
GSM99_RS12415	COG2835	tetraacyldisaccharide 4'-kinase activity
GSM99_RS12420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GSM99_RS12425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GSM99_RS12430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GSM99_RS12435	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GSM99_RS12440	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GSM99_RS12445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GSM99_RS12460	COG3108	Peptidase M15
GSM99_RS12475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GSM99_RS12480	COG0017	Asparaginyl-tRNA synthetase
GSM99_RS12485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GSM99_RS12490	COG0308	aminopeptidase N
GSM99_RS12495	COG0167	dihydroorotate dehydrogenase activity
GSM99_RS12505	COG3217	Mosc domain protein beta barrel domain protein
GSM99_RS12505	COG0633	Ferredoxin
GSM99_RS12510	COG0116	Belongs to the methyltransferase superfamily
GSM99_RS12510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GSM99_RS12515	COG0488	(ABC) transporter
GSM99_RS12520	COG2995	paraquat-inducible protein a
GSM99_RS12525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GSM99_RS12525	COG3008	intermembrane lipid transfer
GSM99_RS12530	COG3009	Protein conserved in bacteria
GSM99_RS12540	COG3130	regulation of translation
GSM99_RS12545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSM99_RS12550	COG1067	ATP-dependent peptidase activity
GSM99_RS12555	COG3120	sequence-specific DNA binding
GSM99_RS12560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GSM99_RS12560	COG2885	chlorophyll binding
GSM99_RS12575	COG1289	transmembrane transporter activity
GSM99_RS12580	COG0210	DNA helicase
GSM99_RS12585	COG1803	Methylglyoxal synthase
GSM99_RS12590	COG1832	CoA-binding protein
GSM99_RS12595	COG3785	DNA binding
GSM99_RS12600	COG1254	Belongs to the acylphosphatase family
GSM99_RS12605	COG2920	part of a sulfur-relay system
GSM99_RS12615	COG1957	nucleoside hydrolase
GSM99_RS12620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSM99_RS12625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSM99_RS12645	COG0583	DNA-binding transcription factor activity
GSM99_RS12655	COG3615	Tellurite resistance protein tehB
GSM99_RS12660	COG0484	heat shock protein binding
GSM99_RS12670	COG1473	amidohydrolase
GSM99_RS12685	COG2207	Transcriptional regulator
GSM99_RS12685	COG3708	Transcriptional regulator
GSM99_RS12705	COG1278	Cold shock
GSM99_RS12710	COG1560	Kdo2-lipid A biosynthetic process
GSM99_RS12770	COG3083	sulfuric ester hydrolase activity
GSM99_RS12780	COG3081	Nucleoid-associated protein
GSM99_RS12785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GSM99_RS12790	COG1061	Type III restriction enzyme res subunit
GSM99_RS12795	COG1187	pseudouridine synthase activity
GSM99_RS12800	COG2814	Major facilitator Superfamily
GSM99_RS12810	COG0791	NLP P60 protein
GSM99_RS12815	COG0671	phosphoesterase, PA-phosphatase related
GSM99_RS12830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSM99_RS12840	COG0494	nUDIX hydrolase
GSM99_RS12845	COG1105	Belongs to the carbohydrate kinase PfkB family
GSM99_RS12850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GSM99_RS12855	COG2855	membrane
GSM99_RS12860	COG0583	DNA-binding transcription factor activity
GSM99_RS12865	COG0833	amino acid
GSM99_RS12870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSM99_RS12875	COG1120	ATPase activity
GSM99_RS12880	COG4771	TonB-dependent receptor
GSM99_RS12890	COG0531	amino acid
GSM99_RS12915	COG3121	Chaperone
GSM99_RS12935	COG2831	hemolysin activation secretion protein
GSM99_RS12940	COG3210	domain, Protein
GSM99_RS12945	COG3210	domain, Protein
GSM99_RS12960	COG5444	nuclease activity
GSM99_RS12990	COG3961	Belongs to the TPP enzyme family
GSM99_RS12995	COG0583	DNA-binding transcription factor activity
GSM99_RS13000	COG0277	FAD linked oxidase domain protein
GSM99_RS13005	COG2925	Exonuclease
GSM99_RS13015	COG2211	Major facilitator Superfamily
GSM99_RS13020	COG2926	Belongs to the UPF0265 family
GSM99_RS13025	COG1530	ribonuclease E activity
GSM99_RS13030	COG0564	pseudouridine synthase activity
GSM99_RS13045	COG1399	metal-binding, possibly nucleic acid-binding protein
GSM99_RS13050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GSM99_RS13060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSM99_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
GSM99_RS13075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSM99_RS13095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSM99_RS13100	COG0470	DNA polymerase III
GSM99_RS13105	COG0084	hydrolase, TatD family'
GSM99_RS13110	COG0537	adenosine 5'-monophosphoramidase activity
GSM99_RS13115	COG5633	Lipoprotein
GSM99_RS13120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
GSM99_RS13130	COG1472	Belongs to the glycosyl hydrolase 3 family
GSM99_RS13145	COG3134	Outer membrane lipoprotein
GSM99_RS13150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GSM99_RS13155	COG4591	ABC-type transport system involved in lipoprotein release permease component
GSM99_RS13160	COG1136	(ABC) transporter
GSM99_RS13165	COG4591	ABC-type transport system involved in lipoprotein release permease component
GSM99_RS13185	COG2850	peptidyl-arginine hydroxylation
GSM99_RS13190	COG2205	protein histidine kinase activity
GSM99_RS13195	COG0745	RESPONSE REGULATOR receiver
GSM99_RS13200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GSM99_RS13205	COG2915	High frequency lysogenization protein hflD homolog
GSM99_RS13210	COG0482	sulfurtransferase activity
GSM99_RS13225	COG0538	isocitrate dehydrogenase activity
GSM99_RS13235	COG1278	Cold shock
GSM99_RS13240	COG0071	Belongs to the small heat shock protein (HSP20) family
GSM99_RS13245	COG1475	DNA binding
GSM99_RS13250	COG3969	phosphoadenosine phosphosulfate
GSM99_RS13255	COG0500	methyltransferase
GSM99_RS13315	COG2841	Protein conserved in bacteria
GSM99_RS13385	COG0024	Methionine aminopeptidase
GSM99_RS13395	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GSM99_RS13400	COG1598	PFAM Uncharacterised protein family UPF0150
GSM99_RS13405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GSM99_RS13415	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GSM99_RS13430	COG0589	response to stress
GSM99_RS13435	COG1528	Iron-storage protein
GSM99_RS13440	COG2372	response to copper ion
GSM99_RS13445	COG1276	copper resistance
GSM99_RS13460	COG3008	intermembrane lipid transfer
GSM99_RS13465	COG2995	paraquat-inducible protein a
GSM99_RS13470	COG1956	GAF domain-containing protein
GSM99_RS13490	COG0501	Belongs to the peptidase M48B family
GSM99_RS13505	COG1988	membrane-bound metal-dependent
GSM99_RS13510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSM99_RS13525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSM99_RS13530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSM99_RS13535	COG1121	(ABC) transporter
GSM99_RS13540	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSM99_RS13560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSM99_RS13575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSM99_RS13580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GSM99_RS13585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GSM99_RS13590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GSM99_RS13600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GSM99_RS13605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSM99_RS13605	COG0072	phenylalanine-tRNA ligase activity
GSM99_RS13610	COG0776	regulation of translation
GSM99_RS13615	COG4139	cobalamin transport
GSM99_RS13625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSM99_RS13630	COG0463	Glycosyl transferase, family 2
GSM99_RS13635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSM99_RS13635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSM99_RS13640	COG0726	polysaccharide deacetylase
GSM99_RS13645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSM99_RS13650	COG2076	Multidrug Resistance protein
GSM99_RS13655	COG2076	Multidrug Resistance protein
GSM99_RS13675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GSM99_RS13680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSM99_RS13685	COG4558	Periplasmic binding protein
GSM99_RS13690	COG3720	iron ion transport
GSM99_RS13695	COG4771	TonB-dependent receptor
GSM99_RS13700	COG4771	TonB-dependent receptor
GSM99_RS13710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GSM99_RS13725	COG0628	permease
GSM99_RS13765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSM99_RS13770	COG2166	iron-sulfur cluster assembly
GSM99_RS13775	COG1376	ErfK ybiS ycfS ynhG family protein
GSM99_RS13775	COG1388	LysM domain
GSM99_RS13805	COG0534	Mate efflux family protein
GSM99_RS13810	COG0307	riboflavin synthase, alpha
GSM99_RS13815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GSM99_RS13820	COG2814	Major facilitator Superfamily
GSM99_RS13825	COG0583	DNA-binding transcription factor activity
GSM99_RS13830	COG1609	Transcriptional regulator
GSM99_RS13840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSM99_RS13850	COG0730	response to heat
GSM99_RS13860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GSM99_RS13865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSM99_RS13870	COG0346	lactoylglutathione lyase activity
GSM99_RS13875	COG3313	Fe-S protein
GSM99_RS13900	COG3133	Outer membrane lipoprotein
GSM99_RS13905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GSM99_RS13910	COG0259	pyridoxamine-phosphate oxidase activity
GSM99_RS13915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GSM99_RS13940	COG4172	Belongs to the ABC transporter superfamily
GSM99_RS13945	COG4172	Belongs to the ABC transporter superfamily
GSM99_RS13965	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSM99_RS13970	COG1842	Phage shock protein A
GSM99_RS13980	COG1983	PspC domain protein
GSM99_RS13990	COG3106	COG3106 Predicted ATPase
GSM99_RS13995	COG3768	UPF0283 membrane protein
GSM99_RS14010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GSM99_RS14015	COG4166	transmembrane transport
GSM99_RS14030	COG0598	Magnesium transport protein CorA
GSM99_RS14075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSM99_RS14090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSM99_RS14105	COG1607	acyl-coa hydrolase
GSM99_RS14110	COG2917	probably involved in intracellular septation
GSM99_RS14135	COG0159	tryptophan synthase activity
GSM99_RS14145	COG0135	phosphoribosylanthranilate isomerase activity
GSM99_RS14145	COG0134	indole-3-glycerol-phosphate synthase activity
GSM99_RS14155	COG0512	Glutamine amidotransferase of anthranilate synthase
GSM99_RS14160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GSM99_RS14165	COG0613	PHP domain protein
GSM99_RS14170	COG0009	L-threonylcarbamoyladenylate synthase
GSM99_RS14175	COG1187	pseudouridine synthase activity
GSM99_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
GSM99_RS14195	COG0616	signal peptide processing
GSM99_RS14205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSM99_RS14215	COG0583	DNA-binding transcription factor activity
GSM99_RS14235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSM99_RS14240	COG0671	phosphoesterase, PA-phosphatase related
GSM99_RS14245	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GSM99_RS14250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GSM99_RS14255	COG0284	orotidine-5'-phosphate decarboxylase activity
GSM99_RS14260	COG0023	Translation Initiation Factor
GSM99_RS14265	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GSM99_RS14270	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GSM99_RS14285	COG4659	FMN binding
GSM99_RS14310	COG4657	Part of a membrane complex involved in electron transport
GSM99_RS14320	COG0673	inositol 2-dehydrogenase activity
GSM99_RS14345	COG5339	Protein conserved in bacteria
GSM99_RS14350	COG0114	fumarate hydratase activity
GSM99_RS14370	COG2814	Major facilitator Superfamily
GSM99_RS14375	COG0583	DNA-binding transcription factor activity
GSM99_RS14380	COG1940	carbohydrate kinase activity
GSM99_RS14385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GSM99_RS14400	COG4221	oxidoreductase activity
GSM99_RS14410	COG1275	C4-dicarboxylate transporter malic acid transport protein
GSM99_RS14415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSM99_RS14430	COG0640	Transcriptional regulator
GSM99_RS14435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GSM99_RS14445	COG2850	peptidyl-arginine hydroxylation
GSM99_RS14460	COG0640	Transcriptional regulator
GSM99_RS14485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSM99_RS14490	COG4628	conserved protein (DUF2132)
GSM99_RS14500	COG2207	Transcriptional regulator
GSM99_RS14500	COG1609	Transcriptional regulator
GSM99_RS14505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GSM99_RS14510	COG1757	Na H antiporter
GSM99_RS14545	COG0443	Heat shock 70 kDa protein
GSM99_RS14555	COG0583	DNA-binding transcription factor activity
GSM99_RS14575	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GSM99_RS14585	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GSM99_RS14615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSM99_RS14625	COG0402	S-adenosylhomocysteine deaminase activity
GSM99_RS14635	COG1671	Belongs to the UPF0178 family
GSM99_RS14640	COG0697	spore germination
GSM99_RS14645	COG1846	Transcriptional regulator
GSM99_RS14650	COG4771	TonB-dependent receptor
GSM99_RS14655	COG4558	Periplasmic binding protein
GSM99_RS14665	COG3721	Heme iron utilization protein
GSM99_RS14675	COG0488	(ABC) transporter
GSM99_RS14695	COG2814	Major facilitator Superfamily
GSM99_RS14700	COG1309	transcriptional regulator
GSM99_RS14705	COG0477	Major facilitator Superfamily
GSM99_RS14825	COG0110	maltose O-acetyltransferase activity
GSM99_RS14845	COG0583	DNA-binding transcription factor activity
GSM99_RS14850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GSM99_RS14855	COG1523	belongs to the glycosyl hydrolase 13 family
GSM99_RS14860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GSM99_RS14865	COG0297	glycogen (starch) synthase activity
GSM99_RS14870	COG0058	SHG alpha-glucan phosphorylase activity
GSM99_RS14890	COG0251	oxidation-reduction process
GSM99_RS14900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSM99_RS14910	COG2376	Dihydroxyacetone kinase
GSM99_RS14970	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS14975	COG3302	dmso reductase anchor subunit
GSM99_RS14980	COG3381	protein complex oligomerization
GSM99_RS15000	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GSM99_RS15005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GSM99_RS15010	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GSM99_RS15015	COG2205	protein histidine kinase activity
GSM99_RS15020	COG0745	RESPONSE REGULATOR receiver
GSM99_RS15040	COG0842	Transport permease protein
GSM99_RS15045	COG1129	ABC transporter
GSM99_RS15045	COG0842	Transport permease protein
GSM99_RS15050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSM99_RS15060	COG4974	Belongs to the 'phage' integrase family
GSM99_RS15065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GSM99_RS15095	COG0574	Belongs to the PEP-utilizing enzyme family
GSM99_RS15095	COG3848	Pyruvate phosphate dikinase
GSM99_RS15115	COG0450	alkyl hydroperoxide reductase
GSM99_RS15130	COG1695	Transcriptional regulator
GSM99_RS15155	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS15160	COG0243	molybdopterin cofactor binding
GSM99_RS15165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSM99_RS15170	COG0589	response to stress
GSM99_RS15175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GSM99_RS15180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GSM99_RS15190	COG0531	amino acid
GSM99_RS15195	COG1643	Atp-dependent helicase
GSM99_RS15210	COG3121	Chaperone
GSM99_RS15215	COG3188	usher protein
GSM99_RS15225	COG3784	Protein of unknown function (DUF1318)
GSM99_RS15235	COG2911	Protein conserved in bacteria
GSM99_RS15240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSM99_RS15260	COG3708	Transcriptional regulator
GSM99_RS15260	COG2207	Transcriptional regulator
GSM99_RS15275	COG4619	ABC transporter
GSM99_RS15280	COG0390	transport system, permease component
GSM99_RS15295	COG2983	Belongs to the UPF0260 family
GSM99_RS15300	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSM99_RS15310	COG3100	YcgL domain-containing protein
GSM99_RS15315	COG0850	regulation of cytokinetic process
GSM99_RS15320	COG2894	cell division
GSM99_RS15325	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GSM99_RS15330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GSM99_RS15335	COG0318	PFAM AMP-dependent synthetase and ligase
GSM99_RS15340	COG3065	identical protein binding
GSM99_RS15350	COG1199	ATP-dependent helicase activity
GSM99_RS15355	COG0251	oxidation-reduction process
GSM99_RS15360	COG0702	epimerase
GSM99_RS15365	COG2076	Multidrug Resistance protein
GSM99_RS15370	COG2076	Multidrug Resistance protein
GSM99_RS15375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GSM99_RS15380	COG1737	Transcriptional regulator
GSM99_RS15385	COG0469	pyruvate kinase activity
GSM99_RS15390	COG1560	Kdo2-lipid A biosynthetic process
GSM99_RS15395	COG0739	heme binding
GSM99_RS15400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GSM99_RS15405	COG1121	(ABC) transporter
GSM99_RS15410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSM99_RS15420	COG2255	four-way junction helicase activity
GSM99_RS15425	COG0632	four-way junction helicase activity
GSM99_RS15430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GSM99_RS15435	COG0217	transcriptional regulatory protein
GSM99_RS15440	COG0494	nUDIX hydrolase
GSM99_RS15450	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GSM99_RS15455	COG2226	methyltransferase
GSM99_RS15460	COG0500	methyltransferase
GSM99_RS15470	COG0488	(ABC) transporter
GSM99_RS15475	COG3142	Participates in the control of copper homeostasis
GSM99_RS15480	COG3102	Protein conserved in bacteria
GSM99_RS15510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSM99_RS15525	COG3381	protein complex oligomerization
GSM99_RS15550	COG0659	secondary active sulfate transmembrane transporter activity
GSM99_RS15555	COG1242	4 iron, 4 sulfur cluster binding
GSM99_RS15560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GSM99_RS15565	COG2912	Transglutaminase-like superfamily
GSM99_RS15575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GSM99_RS15580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GSM99_RS15585	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GSM99_RS15590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GSM99_RS15595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GSM99_RS15605	COG0193	aminoacyl-tRNA hydrolase activity
GSM99_RS15660	COG1122	ATPase activity
GSM99_RS15680	COG2186	Transcriptional regulator
GSM99_RS15685	COG0579	oxidoreductase
GSM99_RS15690	COG0583	DNA-binding transcription factor activity
GSM99_RS15720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSM99_RS15725	COG1271	oxidase subunit
GSM99_RS15730	COG1294	oxidase, subunit
GSM99_RS15740	COG3152	Membrane
GSM99_RS15750	COG3121	Chaperone
GSM99_RS15755	COG3121	Chaperone
GSM99_RS15775	COG3121	Chaperone
GSM99_RS15785	COG1702	phosphate starvation-inducible protein PhoH
GSM99_RS15795	COG2356	endonuclease I
GSM99_RS15805	COG3610	response to peptide
GSM99_RS15810	COG2966	Psort location CytoplasmicMembrane, score
GSM99_RS15820	COG0589	response to stress
GSM99_RS15830	COG0589	response to stress
GSM99_RS15850	COG0113	porphobilinogen synthase activity
GSM99_RS15870	COG0402	S-adenosylhomocysteine deaminase activity
GSM99_RS15875	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GSM99_RS15880	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GSM99_RS15890	COG1309	transcriptional regulator
GSM99_RS15895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSM99_RS15900	COG1280	lysine exporter protein (LysE YggA)
GSM99_RS15910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSM99_RS15945	COG0444	Belongs to the ABC transporter superfamily
GSM99_RS15950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSM99_RS15955	COG0601	transmembrane transport
GSM99_RS15975	COG2146	nitrite reductase [NAD(P)H] activity
GSM99_RS15980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSM99_RS15985	COG0747	negative chemotaxis
GSM99_RS15990	COG0601	transmembrane transport
GSM99_RS16000	COG0444	Belongs to the ABC transporter superfamily
GSM99_RS16005	COG4608	Belongs to the ABC transporter superfamily
GSM99_RS16010	COG2095	MarC family integral membrane protein
GSM99_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
GSM99_RS16015	COG1454	alcohol dehydrogenase
GSM99_RS16020	COG1435	thymidine kinase activity
GSM99_RS16025	COG2916	Histone family protein nucleoid-structuring protein H-NS
GSM99_RS16035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSM99_RS16040	COG0745	RESPONSE REGULATOR receiver
GSM99_RS16045	COG3012	SEC-C Motif Domain Protein
GSM99_RS16050	COG0788	formyltetrahydrofolate deformylase activity
GSM99_RS16065	COG0583	DNA-binding transcription factor activity
GSM99_RS16070	COG0708	Exodeoxyribonuclease III
GSM99_RS16075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSM99_RS16080	COG0709	Synthesizes selenophosphate from selenide and ATP
GSM99_RS16085	COG0778	Nitroreductase
GSM99_RS16090	COG0616	signal peptide processing
GSM99_RS16095	COG0252	asparaginase activity
GSM99_RS16100	COG1335	isochorismatase
GSM99_RS16105	COG3139	Protein of unknown function (DUF1315)
GSM99_RS16110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSM99_RS16125	COG3713	MltA-interacting MipA family protein
GSM99_RS16130	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GSM99_RS16140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSM99_RS16145	COG2186	Transcriptional regulator
GSM99_RS16150	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GSM99_RS16155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GSM99_RS16165	COG2076	Multidrug Resistance protein
GSM99_RS16190	COG2207	Transcriptional regulator
GSM99_RS16195	COG1979	alcohol dehydrogenase
GSM99_RS16270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GSM99_RS16275	COG0322	excinuclease ABC activity
GSM99_RS16280	COG2197	response regulator
GSM99_RS16300	COG1494	fructose-1,6-bisphosphatase
GSM99_RS16305	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GSM99_RS16360	COG3842	ATPase activity
GSM99_RS16370	COG0725	ABC transporter, periplasmic molybdate-binding protein
GSM99_RS16380	COG1324	tolerance protein
GSM99_RS16395	COG3541	Predicted nucleotidyltransferase
GSM99_RS16495	COG4691	Plasmid stability protein
GSM99_RS16515	COG0582	viral genome integration into host DNA
GSM99_RS16520	COG0519	Catalyzes the synthesis of GMP from XMP
GSM99_RS16520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSM99_RS16525	COG0517	IMP dehydrogenase activity
GSM99_RS16525	COG0516	GMP reductase activity
GSM99_RS16530	COG1570	exodeoxyribonuclease VII activity
GSM99_RS16535	COG4206	TonB-dependent receptor
GSM99_RS16535	COG1629	transport
GSM99_RS16540	COG1770	oligopeptidase
GSM99_RS16555	COG0280	phosphate acetyltransferase
GSM99_RS16555	COG0281	malic enzyme
GSM99_RS16560	COG2197	response regulator
GSM99_RS16570	COG1393	Belongs to the ArsC family
GSM99_RS16575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSM99_RS16580	COG1876	peptidase activity
GSM99_RS16585	COG2832	Protein of unknown function (DUF454)
GSM99_RS16595	COG1444	tRNA N-acetyltransferase activity
GSM99_RS16600	COG2707	UPF0756 membrane protein
GSM99_RS16605	COG2321	neutral zinc metallopeptidase
GSM99_RS16610	COG2378	regulation of single-species biofilm formation
GSM99_RS16620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GSM99_RS16630	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GSM99_RS16635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSM99_RS16640	COG2716	regulation of RNA biosynthetic process
GSM99_RS16645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GSM99_RS16650	COG0628	permease
GSM99_RS16655	COG4783	chaperone-mediated protein folding
GSM99_RS16660	COG1393	Belongs to the ArsC family
GSM99_RS16665	COG2211	Major facilitator Superfamily
GSM99_RS16670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSM99_RS16675	COG0668	transmembrane transport
GSM99_RS16680	COG2233	PERMEase
GSM99_RS16685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GSM99_RS16690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GSM99_RS16695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GSM99_RS16700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSM99_RS16705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GSM99_RS16710	COG0248	Ppx GppA phosphatase
GSM99_RS16715	COG2239	Acts as a magnesium transporter
GSM99_RS16730	COG3104	oligopeptide transport
GSM99_RS16735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSM99_RS16740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSM99_RS16745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSM99_RS16750	COG2205	protein histidine kinase activity
GSM99_RS16755	COG0745	RESPONSE REGULATOR receiver
GSM99_RS16765	COG1597	lipid kinase activity
GSM99_RS16770	COG1830	Aldolase
GSM99_RS16775	COG0351	phosphomethylpyrimidine kinase
GSM99_RS16785	COG1113	amino acid transport
GSM99_RS16800	COG0561	phosphatase activity
GSM99_RS16805	COG1114	Component of the transport system for branched-chain amino acids
GSM99_RS16810	COG3023	N-Acetylmuramoyl-L-alanine amidase
GSM99_RS16815	COG1115	amino acid carrier protein
GSM99_RS16830	COG3140	Belongs to the UPF0181 family
GSM99_RS16835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GSM99_RS16840	COG0494	nUDIX hydrolase
GSM99_RS16850	COG1971	Probably functions as a manganese efflux pump
GSM99_RS16855	COG2226	methyltransferase
GSM99_RS16870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GSM99_RS17005	COG4695	Portal protein
GSM99_RS17075	COG4974	Belongs to the 'phage' integrase family
GSM99_RS17085	COG3121	Chaperone
GSM99_RS17140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSM99_RS17145	COG0506	proline dehydrogenase activity
GSM99_RS17145	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GSM99_RS17145	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GSM99_RS17155	COG1191	sigma factor activity
GSM99_RS17190	COG2153	protein acetylation
GSM99_RS17215	COG3136	membrane protein required for alginate biosynthesis
GSM99_RS17225	COG1677	Flagellar hook-basal body complex protein FliE
GSM99_RS17230	COG1766	The M ring may be actively involved in energy transduction
GSM99_RS17235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSM99_RS17240	COG1317	bacterial-type flagellum organization
GSM99_RS17245	COG1157	protein secretion by the type III secretion system
GSM99_RS17250	COG2882	bacterial-type flagellum organization
GSM99_RS17260	COG1580	Controls the rotational direction of flagella during chemotaxis
GSM99_RS17275	COG3190	flagellar
GSM99_RS17280	COG1338	Plays a role in the flagellum-specific transport system
GSM99_RS17285	COG1987	bacterial-type flagellum assembly
GSM99_RS17310	COG1256	bacterial-type flagellum assembly
GSM99_RS17320	COG1706	bacterial-type flagellum-dependent cell motility
GSM99_RS17325	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GSM99_RS17330	COG4786	Flagellar basal body rod
GSM99_RS17340	COG1749	Flagellar hook protein flgE
GSM99_RS17345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GSM99_RS17350	COG1558	bacterial-type flagellum-dependent cell motility
GSM99_RS17355	COG1815	bacterial-type flagellum-dependent cell motility
GSM99_RS17380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSM99_RS17390	COG0745	RESPONSE REGULATOR receiver
GSM99_RS17395	COG2201	protein-glutamate methylesterase activity
GSM99_RS17405	COG0840	transmembrane signaling receptor activity
GSM99_RS17410	COG0840	transmembrane signaling receptor activity
GSM99_RS17415	COG0835	chemotaxis
GSM99_RS17420	COG2198	Histidine kinase
GSM99_RS17420	COG0643	Histidine kinase
GSM99_RS17425	COG1360	Flagellar Motor Protein
GSM99_RS17430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GSM99_RS17470	COG1278	Cold shock
GSM99_RS17485	COG2249	NAD(P)H dehydrogenase (quinone) activity
GSM99_RS17490	COG2207	Transcriptional regulator
GSM99_RS17510	COG0418	dihydroorotase activity
GSM99_RS17550	COG1560	Kdo2-lipid A biosynthetic process
GSM99_RS17555	COG2814	Major facilitator Superfamily
GSM99_RS17570	COG1607	acyl-coa hydrolase
GSM99_RS17590	COG1902	pentaerythritol trinitrate reductase activity
GSM99_RS17625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GSM99_RS17640	COG3247	response to pH
GSM99_RS17650	COG0668	transmembrane transport
GSM99_RS17660	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS17665	COG3302	dmso reductase anchor subunit
GSM99_RS17680	COG2207	Transcriptional regulator
GSM99_RS17680	COG3708	Transcriptional regulator
GSM99_RS17810	COG0642	Histidine kinase
GSM99_RS17810	COG2198	Histidine kinase
GSM99_RS17815	COG2197	response regulator
GSM99_RS17830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GSM99_RS17840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSM99_RS17845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSM99_RS17850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSM99_RS17860	COG0814	amino acid
GSM99_RS17880	COG1441	menaquinone biosynthetic process
GSM99_RS17885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GSM99_RS17890	COG0596	Alpha beta hydrolase
GSM99_RS17895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GSM99_RS17900	COG1169	isochorismate synthase
GSM99_RS17915	COG1007	ATP synthesis coupled electron transport
GSM99_RS17920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSM99_RS17930	COG0713	ATP synthesis coupled electron transport
GSM99_RS17935	COG0839	Belongs to the complex I subunit 6 family
GSM99_RS17940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSM99_RS17945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GSM99_RS17950	COG1034	ATP synthesis coupled electron transport
GSM99_RS17955	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GSM99_RS17960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GSM99_RS17965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSM99_RS17965	COG0649	NAD binding
GSM99_RS17970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSM99_RS17975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSM99_RS17980	COG0583	DNA-binding transcription factor activity
GSM99_RS17985	COG0436	Aminotransferase
GSM99_RS17990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GSM99_RS18000	COG0490	domain, Protein
GSM99_RS18000	COG0471	metal ion transport
GSM99_RS18010	COG3013	Belongs to the UPF0304 family
GSM99_RS18015	COG3092	negative regulation of chromosome organization
GSM99_RS18020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSM99_RS18050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSM99_RS18055	COG1609	Transcriptional regulator
GSM99_RS18060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GSM99_RS18065	COG0625	glutathione transferase activity
GSM99_RS18070	COG1090	epimerase
GSM99_RS18075	COG0163	prenyltransferase activity
GSM99_RS18080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GSM99_RS18085	COG1286	toxin biosynthetic process
GSM99_RS18090	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GSM99_RS18095	COG0285	dihydrofolate synthase activity
GSM99_RS18100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GSM99_RS18105	COG0586	Pfam SNARE associated Golgi protein
GSM99_RS18115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GSM99_RS18120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSM99_RS18125	COG2207	Transcriptional regulator
GSM99_RS18130	COG0697	spore germination
GSM99_RS18135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSM99_RS18140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSM99_RS18140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GSM99_RS18160	COG3101	peptidyl-lysine hydroxylation
GSM99_RS18165	COG0730	response to heat
GSM99_RS18175	COG2890	protein-(glutamine-N5) methyltransferase activity
GSM99_RS18180	COG2840	Smr protein MutS2
GSM99_RS18185	COG2062	phosphohistidine phosphatase, SixA
GSM99_RS18190	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSM99_RS18190	COG1024	Enoyl-CoA hydratase
GSM99_RS18195	COG0183	Belongs to the thiolase family
GSM99_RS18200	COG3691	Protein conserved in bacteria
GSM99_RS18205	COG2067	long-chain fatty acid transport protein
GSM99_RS18215	COG4319	ketosteroid isomerase
GSM99_RS18235	COG2207	Transcriptional regulator
GSM99_RS18250	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS18270	COG1396	sequence-specific DNA binding
GSM99_RS18315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSM99_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
GSM99_RS18340	COG3530	Putative quorum-sensing-regulated virulence factor
GSM99_RS18345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSM99_RS18350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSM99_RS18355	COG3115	cell septum assembly
GSM99_RS18370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSM99_RS18375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSM99_RS18380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSM99_RS18385	COG2190	(PTS) system
GSM99_RS18395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GSM99_RS18400	COG4208	sulfate ABC transporter
GSM99_RS18405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GSM99_RS18410	COG4150	thiosulfate binding
GSM99_RS18415	COG2837	iron assimilation
GSM99_RS18425	COG0456	acetyltransferase
GSM99_RS18430	COG0408	coproporphyrinogen oxidase activity
GSM99_RS18440	COG1160	GTP binding
GSM99_RS18445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSM99_RS18450	COG2976	Protein conserved in bacteria
GSM99_RS18455	COG0124	histidyl-tRNA synthetase
GSM99_RS18460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSM99_RS18475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSM99_RS18480	COG0105	UTP biosynthetic process
GSM99_RS18485	COG4953	penicillin-binding protein 1C
GSM99_RS18505	COG2975	iron-sulfur cluster assembly
GSM99_RS18510	COG0633	Ferredoxin
GSM99_RS18515	COG0443	Heat shock 70 kDa protein
GSM99_RS18520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GSM99_RS18525	COG0316	Belongs to the HesB IscA family
GSM99_RS18530	COG0822	iron-sulfur transferase activity
GSM99_RS18535	COG1104	cysteine desulfurase activity
GSM99_RS18540	COG1959	2 iron, 2 sulfur cluster binding
GSM99_RS18545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GSM99_RS18550	COG0483	inositol monophosphate 1-phosphatase activity
GSM99_RS18565	COG2814	Major facilitator Superfamily
GSM99_RS18570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSM99_RS18575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSM99_RS18575	COG1017	nitric oxide dioxygenase activity
GSM99_RS18585	COG0347	Belongs to the P(II) protein family
GSM99_RS18590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSM99_RS18590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GSM99_RS18595	COG2204	response regulator
GSM99_RS18600	COG3170	Tfp pilus assembly protein FimV
GSM99_RS18605	COG2205	protein histidine kinase activity
GSM99_RS18610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSM99_RS18610	COG0047	phosphoribosylformylglycinamidine synthase activity
GSM99_RS18615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GSM99_RS18640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSM99_RS18675	COG3736	Type IV secretory pathway, component VirB8
GSM99_RS18695	COG3451	type IV secretory pathway VirB4
GSM99_RS18875	COG3316	Transposase and inactivated derivatives
GSM99_RS18920	COG3316	Transposase and inactivated derivatives
GSM99_RS18935	COG2336	PFAM SpoVT AbrB
GSM99_RS18940	COG2337	Toxic component of a toxin-antitoxin (TA) module
GSM99_RS19010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GSM99_RS19020	COG1061	Type III restriction enzyme res subunit
GSM99_RS19025	COG1002	Type II restriction enzyme, methylase subunits
GSM99_RS19030	COG3316	Transposase and inactivated derivatives
GSM99_RS19035	COG4221	oxidoreductase activity
GSM99_RS19115	COG3316	Transposase and inactivated derivatives
GSM99_RS19150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSM99_RS19185	COG3316	Transposase and inactivated derivatives
GSM99_RS19250	COG3316	Transposase and inactivated derivatives
GSM99_RS19440	COG0681	Belongs to the peptidase S26 family
GSM99_RS19615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSM99_RS19620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSM99_RS19630	COG0629	single-stranded DNA binding
GSM99_RS19655	COG1192	Involved in chromosome partitioning
GSM99_RS19660	COG2336	PFAM SpoVT AbrB
GSM99_RS19665	COG2337	Toxic component of a toxin-antitoxin (TA) module
GSM99_RS19710	COG0437	4 iron, 4 sulfur cluster binding
GSM99_RS19720	COG0243	molybdopterin cofactor binding
GSM99_RS19730	COG0488	(ABC) transporter
GSM99_RS19735	COG0702	epimerase
GSM99_RS19755	COG0789	Transcriptional regulator
GSM99_RS19775	COG1192	Involved in chromosome partitioning