locus-tag	class	description
HRD54_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD54_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRD54_RS00020	COG0187	DNA topoisomerase II activity
HRD54_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD54_RS00030	COG4106	trans-aconitate 2-methyltransferase activity
HRD54_RS00050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRD54_RS00155	COG1561	YicC-like family, N-terminal region
HRD54_RS00160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRD54_RS00165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRD54_RS00170	COG1309	transcriptional regulator
HRD54_RS00175	COG0756	dUTP diphosphatase activity
HRD54_RS00180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRD54_RS00185	COG2003	Belongs to the UPF0758 family
HRD54_RS00190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD54_RS00195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD54_RS00200	COG0438	transferase activity, transferring glycosyl groups
HRD54_RS00210	COG0297	glycogen (starch) synthase activity
HRD54_RS00225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRD54_RS00230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRD54_RS00240	COG1519	Transferase
HRD54_RS00250	COG0438	transferase activity, transferring glycosyl groups
HRD54_RS00255	COG0859	PFAM glycosyl transferase family 9
HRD54_RS00270	COG0859	PFAM glycosyl transferase family 9
HRD54_RS00280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD54_RS00285	COG0156	8-amino-7-oxononanoate synthase activity
HRD54_RS00290	COG1063	alcohol dehydrogenase
HRD54_RS00295	COG2861	carbohydrate metabolic process
HRD54_RS00300	COG4942	peptidase
HRD54_RS00305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD54_RS00315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD54_RS00320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRD54_RS00330	COG1045	serine acetyltransferase
HRD54_RS00335	COG1045	serine acetyltransferase
HRD54_RS00340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRD54_RS00350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD54_RS00370	COG0438	transferase activity, transferring glycosyl groups
HRD54_RS00375	COG1442	glycosyl transferase family 8
HRD54_RS00375	COG1216	Glycosyl transferase, family 2
HRD54_RS00410	COG2205	protein histidine kinase activity
HRD54_RS00415	COG0745	RESPONSE REGULATOR receiver
HRD54_RS00420	COG3678	ATP-independent chaperone mediated protein folding
HRD54_RS00430	COG0438	transferase activity, transferring glycosyl groups
HRD54_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS00440	COG0205	6-phosphofructokinase activity
HRD54_RS00445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRD54_RS00450	COG0149	triose-phosphate isomerase activity
HRD54_RS00460	COG3152	Membrane
HRD54_RS00465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD54_RS00470	COG2814	Major facilitator Superfamily
HRD54_RS00475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD54_RS00485	COG3074	FtsZ-dependent cytokinesis
HRD54_RS00495	COG1396	sequence-specific DNA binding
HRD54_RS00500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD54_RS00505	COG1575	Belongs to the MenA family. Type 1 subfamily
HRD54_RS00510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRD54_RS00515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRD54_RS00520	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD54_RS00525	COG1609	Transcriptional regulator
HRD54_RS00530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRD54_RS00535	COG0254	rRNA binding
HRD54_RS00540	COG3550	peptidyl-serine autophosphorylation
HRD54_RS00545	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HRD54_RS00550	COG0626	cystathionine gamma-synthase activity
HRD54_RS00555	COG0460	homoserine dehydrogenase
HRD54_RS00555	COG0527	aspartate kinase activity
HRD54_RS00560	COG2862	Uncharacterized protein family, UPF0114
HRD54_RS00570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRD54_RS00575	COG1216	Glycosyl transferase, family 2
HRD54_RS00585	COG0477	Major facilitator Superfamily
HRD54_RS00590	COG0583	DNA-binding transcription factor activity
HRD54_RS00610	COG0028	Belongs to the TPP enzyme family
HRD54_RS00615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD54_RS00620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRD54_RS00625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD54_RS00630	COG0137	argininosuccinate synthase activity
HRD54_RS00635	COG0165	Argininosuccinate lyase
HRD54_RS00645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD54_RS00660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD54_RS00665	COG4206	TonB-dependent receptor
HRD54_RS00670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRD54_RS00705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRD54_RS00715	COG1072	(Pantothenic acid kinase))
HRD54_RS00755	COG0051	transcription antitermination factor activity, RNA binding
HRD54_RS00760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRD54_RS00765	COG0088	Forms part of the polypeptide exit tunnel
HRD54_RS00770	COG0089	rRNA binding
HRD54_RS00775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRD54_RS00780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRD54_RS00785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRD54_RS00795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRD54_RS00800	COG0255	Belongs to the universal ribosomal protein uL29 family
HRD54_RS00805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRD54_RS00810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRD54_RS00815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRD54_RS00820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRD54_RS00825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD54_RS00830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRD54_RS00835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRD54_RS00840	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRD54_RS00845	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRD54_RS00850	COG1841	ribosomal large subunit assembly
HRD54_RS00855	COG0200	Binds to the 23S rRNA
HRD54_RS00860	COG0201	protein transport
HRD54_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD54_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRD54_RS00880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD54_RS00890	COG0203	ribosomal protein L17
HRD54_RS00895	COG0789	Transcriptional regulator
HRD54_RS00900	COG3036	rescue of stalled ribosome
HRD54_RS00905	COG1970	mechanosensitive ion channel activity
HRD54_RS00910	COG0569	domain protein
HRD54_RS00915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRD54_RS00915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD54_RS00920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD54_RS00925	COG0242	peptide deformylase activity
HRD54_RS00930	COG0758	DNA mediated transformation
HRD54_RS00935	COG0551	DNA topoisomerase type I activity
HRD54_RS00940	COG0009	L-threonylcarbamoyladenylate synthase
HRD54_RS00945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD54_RS00955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRD54_RS00995	COG0583	DNA-binding transcription factor activity
HRD54_RS01000	COG3085	chromosome segregation
HRD54_RS01005	COG0606	chelatase, subunit chli
HRD54_RS01020	COG3978	acetolactate synthase activity
HRD54_RS01030	COG0129	dihydroxy-acid dehydratase activity
HRD54_RS01035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD54_RS01045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD54_RS01050	COG3041	Addiction module toxin RelE StbE family
HRD54_RS01060	COG0210	DNA helicase
HRD54_RS01065	COG0248	Ppx GppA phosphatase
HRD54_RS01070	COG0513	Belongs to the DEAD box helicase family
HRD54_RS01075	COG3118	belongs to the thioredoxin family
HRD54_RS01080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRD54_RS01085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD54_RS01095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRD54_RS01100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRD54_RS01105	COG1088	dTDP-glucose 4,6-dehydratase activity
HRD54_RS01110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRD54_RS01115	COG0456	acetyltransferase
HRD54_RS01120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD54_RS01125	COG2244	polysaccharide biosynthetic process
HRD54_RS01130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD54_RS01140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRD54_RS01170	COG0675	Transposase, IS605 OrfB family
HRD54_RS01180	COG3071	HemY protein
HRD54_RS01185	COG2959	enzyme of heme biosynthesis
HRD54_RS01195	COG0181	hydroxymethylbilane synthase activity
HRD54_RS01205	COG1965	Belongs to the frataxin family
HRD54_RS01210	COG5567	small periplasmic lipoprotein
HRD54_RS01215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRD54_RS01230	COG1011	Hydrolase
HRD54_RS01235	COG0210	DNA helicase
HRD54_RS01245	COG2962	Rard protein
HRD54_RS01250	COG2050	protein possibly involved in aromatic compounds catabolism
HRD54_RS01265	COG2267	carboxylic ester hydrolase activity
HRD54_RS01270	COG0561	phosphatase activity
HRD54_RS01280	COG3188	usher protein
HRD54_RS01285	COG3121	Chaperone
HRD54_RS01290	COG3539	Fimbrial protein
HRD54_RS01300	COG3264	Mechanosensitive ion channel
HRD54_RS01300	COG1511	domain protein
HRD54_RS01305	COG0688	phosphatidylethanolamine metabolic process
HRD54_RS01310	COG1162	GTPase activity
HRD54_RS01315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRD54_RS01345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRD54_RS01350	COG0802	atpase or kinase
HRD54_RS01355	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD54_RS01360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRD54_RS01365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRD54_RS01370	COG1923	regulation of RNA biosynthetic process
HRD54_RS01375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRD54_RS01380	COG0330	HflC and HflK could
HRD54_RS01385	COG0330	HflC and HflK could
HRD54_RS01390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRD54_RS01395	COG1959	2 iron, 2 sulfur cluster binding
HRD54_RS01400	COG0557	exoribonuclease II activity
HRD54_RS01405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD54_RS01410	COG0360	Binds together with S18 to 16S ribosomal RNA
HRD54_RS01415	COG2965	DNA replication, synthesis of RNA primer
HRD54_RS01420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD54_RS01425	COG0359	binds to the 23S rRNA
HRD54_RS01430	COG3061	Opacity-associated protein A
HRD54_RS01435	COG0254	rRNA binding
HRD54_RS01440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD54_RS01445	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRD54_RS01450	COG1012	belongs to the aldehyde dehydrogenase family
HRD54_RS01455	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD54_RS01465	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HRD54_RS01475	COG1253	flavin adenine dinucleotide binding
HRD54_RS01480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD54_RS01485	COG0729	surface antigen
HRD54_RS01490	COG2911	Protein conserved in bacteria
HRD54_RS01495	COG2105	PFAM AIG2 family protein
HRD54_RS01515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRD54_RS01520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRD54_RS01525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD54_RS01530	COG1438	arginine binding
HRD54_RS01535	COG0039	L-malate dehydrogenase activity
HRD54_RS01540	COG3423	Transcriptional regulator
HRD54_RS01555	COG0142	geranyltranstransferase activity
HRD54_RS01560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRD54_RS01565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRD54_RS01570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRD54_RS01575	COG2027	D-alanyl-D-alanine carboxypeptidase
HRD54_RS01585	COG1534	Rna-binding protein
HRD54_RS01590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRD54_RS01595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRD54_RS01600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRD54_RS01605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRD54_RS01610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRD54_RS01625	COG0779	Required for maturation of 30S ribosomal subunits
HRD54_RS01630	COG0195	Participates in both transcription termination and antitermination
HRD54_RS01635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRD54_RS01635	COG3064	Membrane
HRD54_RS01640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRD54_RS01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRD54_RS01650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRD54_RS01655	COG1185	polyribonucleotide nucleotidyltransferase activity
HRD54_RS01665	COG0513	Belongs to the DEAD box helicase family
HRD54_RS01670	COG2964	Protein conserved in bacteria
HRD54_RS01680	COG0251	oxidation-reduction process
HRD54_RS01685	COG2271	Major facilitator Superfamily
HRD54_RS01715	COG3275	phosphorelay sensor kinase activity
HRD54_RS01720	COG1566	PFAM secretion protein HlyD family protein
HRD54_RS01735	COG3539	Fimbrial protein
HRD54_RS01740	COG3121	Chaperone
HRD54_RS01745	COG3188	usher protein
HRD54_RS01750	COG3539	Fimbrial protein
HRD54_RS01755	COG3539	Fimbrial protein
HRD54_RS01775	COG0826	peptidase U32
HRD54_RS01780	COG0826	peptidase U32
HRD54_RS01785	COG3154	lipid carrier protein
HRD54_RS01790	COG3153	acetyltransferase
HRD54_RS01795	COG2827	Endonuclease containing a URI domain
HRD54_RS01820	COG0602	queuosine metabolic process
HRD54_RS01825	COG1328	CTP reductase activity
HRD54_RS01830	COG0251	oxidation-reduction process
HRD54_RS01835	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HRD54_RS01840	COG0540	Belongs to the ATCase OTCase family
HRD54_RS01850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRD54_RS01855	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HRD54_RS01870	COG0456	acetyltransferase
HRD54_RS01875	COG0525	valine-tRNA ligase activity
HRD54_RS01880	COG2927	DNA polymerase III (CHI subunit)
HRD54_RS01885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD54_RS01890	COG0795	lipopolysaccharide-transporting ATPase activity
HRD54_RS01895	COG0795	lipopolysaccharide-transporting ATPase activity
HRD54_RS01900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD54_RS01935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HRD54_RS01940	COG1690	Belongs to the RtcB family
HRD54_RS01945	COG1349	DNA-binding transcription factor activity
HRD54_RS01950	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRD54_RS01960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRD54_RS01965	COG1263	PTS System
HRD54_RS01965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS01985	COG0028	Belongs to the TPP enzyme family
HRD54_RS01990	COG0440	acetolactate synthase activity
HRD54_RS02010	COG2252	PERMEase
HRD54_RS02015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD54_RS02020	COG0025	NhaP-type Na H and K H
HRD54_RS02030	COG0583	DNA-binding transcription factor activity
HRD54_RS02035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRD54_RS02045	COG3753	Protein conserved in bacteria
HRD54_RS02060	COG0586	Pfam SNARE associated Golgi protein
HRD54_RS02065	COG1322	Protein conserved in bacteria
HRD54_RS02070	COG2226	methyltransferase
HRD54_RS02075	COG3165	ubiquinone biosynthetic process from chorismate
HRD54_RS02085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD54_RS02090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD54_RS02095	COG0805	protein transport
HRD54_RS02105	COG0675	Transposase, IS605 OrfB family
HRD54_RS02120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRD54_RS02130	COG0183	Belongs to the thiolase family
HRD54_RS02135	COG1024	Enoyl-CoA hydratase
HRD54_RS02135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD54_RS02140	COG0006	proline dipeptidase activity
HRD54_RS02145	COG1739	Uncharacterized protein family UPF0029
HRD54_RS02150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRD54_RS02185	COG1914	H( )-stimulated, divalent metal cation uptake system
HRD54_RS02190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRD54_RS02195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRD54_RS02200	COG4770	biotin carboxylase activity
HRD54_RS02205	COG0730	response to heat
HRD54_RS02220	COG0583	DNA-binding transcription factor activity
HRD54_RS02225	COG2197	response regulator
HRD54_RS02230	COG3850	Histidine kinase
HRD54_RS02235	COG2223	nitrite transmembrane transporter activity
HRD54_RS02240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HRD54_RS02245	COG1140	nitrate reductase beta subunit
HRD54_RS02250	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HRD54_RS02255	COG2181	nitrate reductase activity
HRD54_RS02260	COG1304	FMN binding
HRD54_RS02265	COG2194	sulfuric ester hydrolase activity
HRD54_RS02280	COG3604	Transcriptional regulator
HRD54_RS02285	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD54_RS02290	COG0375	protein maturation
HRD54_RS02295	COG0298	carbon dioxide binding
HRD54_RS02300	COG2076	Multidrug Resistance protein
HRD54_RS02305	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD54_RS02310	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD54_RS02315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD54_RS02320	COG1053	succinate dehydrogenase
HRD54_RS02325	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HRD54_RS02330	COG0584	glycerophosphoryl diester phosphodiesterase
HRD54_RS02335	COG2271	Major facilitator Superfamily
HRD54_RS02340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD54_RS02350	COG0247	lactate metabolic process
HRD54_RS02360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRD54_RS02365	COG0425	Belongs to the sulfur carrier protein TusA family
HRD54_RS02375	COG0675	Transposase, IS605 OrfB family
HRD54_RS02390	COG2217	Heavy metal translocating P-type atpase
HRD54_RS02395	COG3714	YhhN family
HRD54_RS02405	COG3776	membrane
HRD54_RS02410	COG0742	ribosomal rna small subunit methyltransferase
HRD54_RS02415	COG0552	protein localization to endoplasmic reticulum
HRD54_RS02420	COG2884	Cell division ATP-binding protein ftsE
HRD54_RS02425	COG2177	Part of the ABC transporter FtsEX involved in
HRD54_RS02435	COG1929	Belongs to the glycerate kinase type-1 family
HRD54_RS02445	COG2814	Major facilitator Superfamily
HRD54_RS02450	COG1846	Transcriptional regulator
HRD54_RS02455	COG0501	Belongs to the peptidase M48B family
HRD54_RS02460	COG3842	ATPase activity
HRD54_RS02465	COG0395	ABC-type sugar transport system, permease component
HRD54_RS02475	COG1653	transport
HRD54_RS02480	COG0584	glycerophosphoryl diester phosphodiesterase
HRD54_RS02485	COG2807	transmembrane transport
HRD54_RS02510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HRD54_RS02515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD54_RS02520	COG2264	protein methyltransferase activity
HRD54_RS02525	COG4145	pantothenate transmembrane transporter activity
HRD54_RS02530	COG3924	membrane
HRD54_RS02535	COG0439	Biotin carboxylase
HRD54_RS02540	COG0511	ligase activity, forming carbon-carbon bonds
HRD54_RS02545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRD54_RS02550	COG0604	alcohol dehydrogenase
HRD54_RS02555	COG1077	Cell shape determining protein MreB Mrl
HRD54_RS02560	COG1792	Involved in formation and maintenance of cell shape
HRD54_RS02565	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HRD54_RS02570	COG0424	maF-like protein
HRD54_RS02575	COG1530	ribonuclease E activity
HRD54_RS02580	COG3164	Protein of unknown function
HRD54_RS02585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD54_RS02590	COG0312	modulator of DNA gyrase
HRD54_RS02600	COG2732	(Barnase) inhibitor
HRD54_RS02605	COG3028	Belongs to the UPF0307 family
HRD54_RS02610	COG0312	modulator of DNA gyrase
HRD54_RS02615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD54_RS02620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD54_RS02625	COG1660	Displays ATPase and GTPase activities
HRD54_RS02635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD54_RS02640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HRD54_RS02645	COG1137	ATPase activity
HRD54_RS02650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRD54_RS02655	COG3117	lipopolysaccharide transmembrane transporter activity
HRD54_RS02660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRD54_RS02665	COG0517	IMP dehydrogenase activity
HRD54_RS02665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRD54_RS02670	COG0530	calcium, potassium:sodium antiporter activity
HRD54_RS02675	COG1127	ABC transporter
HRD54_RS02680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD54_RS02685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD54_RS02690	COG2854	intermembrane phospholipid transfer
HRD54_RS02700	COG5007	Belongs to the BolA IbaG family
HRD54_RS02705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRD54_RS02715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD54_RS02720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD54_RS02725	COG3105	Protein conserved in bacteria
HRD54_RS02730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HRD54_RS02735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRD54_RS02740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRD54_RS02745	COG0625	glutathione transferase activity
HRD54_RS02750	COG2969	positive regulation of protein catabolic process
HRD54_RS02760	COG1473	amidohydrolase
HRD54_RS02765	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD54_RS02770	COG0493	'glutamate synthase
HRD54_RS02775	COG0069	glutamate synthase activity
HRD54_RS02775	COG0067	glutamate synthase
HRD54_RS02775	COG0070	glutamate synthase
HRD54_RS02780	COG5002	protein histidine kinase activity
HRD54_RS02780	COG0784	Response regulator, receiver
HRD54_RS02780	COG2198	Histidine kinase
HRD54_RS02785	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HRD54_RS02790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD54_RS02795	COG2207	Transcriptional regulator
HRD54_RS02800	COG0829	nickel cation binding
HRD54_RS02805	COG0831	urea catabolic process
HRD54_RS02810	COG0832	Belongs to the urease beta subunit family
HRD54_RS02815	COG0804	urea catabolic process
HRD54_RS02820	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRD54_RS02825	COG0830	nickel cation binding
HRD54_RS02830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD54_RS02835	COG2823	Periplasmic or secreted lipoprotein
HRD54_RS02840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRD54_RS02845	COG0792	nuclease activity
HRD54_RS02855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRD54_RS02865	COG1741	Belongs to the pirin family
HRD54_RS02870	COG0583	DNA-binding transcription factor activity
HRD54_RS02875	COG2259	Doxx family
HRD54_RS02885	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HRD54_RS02890	COG4575	ribosome binding
HRD54_RS02895	COG0586	Pfam SNARE associated Golgi protein
HRD54_RS02900	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRD54_RS02905	COG1902	pentaerythritol trinitrate reductase activity
HRD54_RS02905	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD54_RS02915	COG0612	Peptidase, M16
HRD54_RS02920	COG4178	(ABC) transporter
HRD54_RS02925	COG4771	TonB-dependent receptor
HRD54_RS02935	COG1595	DNA-templated transcription, initiation
HRD54_RS02945	COG0488	(ABC) transporter
HRD54_RS02950	COG0741	lytic transglycosylase activity
HRD54_RS02955	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HRD54_RS02960	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HRD54_RS02965	COG0406	alpha-ribazole phosphatase activity
HRD54_RS02970	COG2207	Transcriptional regulator
HRD54_RS02970	COG3708	Transcriptional regulator
HRD54_RS02975	COG3045	CreA protein
HRD54_RS02980	COG0745	RESPONSE REGULATOR receiver
HRD54_RS02990	COG0083	homoserine kinase activity
HRD54_RS03005	COG3022	response to hydroperoxide
HRD54_RS03010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD54_RS03020	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRD54_RS03025	COG0443	Heat shock 70 kDa protein
HRD54_RS03030	COG0484	heat shock protein binding
HRD54_RS03035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD54_RS03040	COG0583	DNA-binding transcription factor activity
HRD54_RS03045	COG0268	Binds directly to 16S ribosomal RNA
HRD54_RS03055	COG0196	riboflavin kinase activity
HRD54_RS03060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRD54_RS03065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRD54_RS03070	COG1047	Peptidyl-prolyl cis-trans
HRD54_RS03075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRD54_RS03080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRD54_RS03100	COG1470	cell adhesion involved in biofilm formation
HRD54_RS03100	COG1388	LysM domain
HRD54_RS03110	COG1979	alcohol dehydrogenase
HRD54_RS03115	COG2226	methyltransferase
HRD54_RS03125	COG0626	cystathionine gamma-synthase activity
HRD54_RS03130	COG0811	peptide transport
HRD54_RS03135	COG0848	biopolymer transport protein
HRD54_RS03145	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRD54_RS03150	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS03155	COG5557	Pfam Polysulphide reductase, NrfD
HRD54_RS03160	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRD54_RS03165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD54_RS03170	COG1773	rubredoxin
HRD54_RS03175	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD54_RS03180	COG0298	carbon dioxide binding
HRD54_RS03185	COG0409	Hydrogenase expression formation protein
HRD54_RS03190	COG0309	Hydrogenase expression formation protein (HypE)
HRD54_RS03195	COG2391	methyltransferase activity
HRD54_RS03200	COG0425	Belongs to the sulfur carrier protein TusA family
HRD54_RS03205	COG2974	May be involved in recombination
HRD54_RS03215	COG0737	Belongs to the 5'-nucleotidase family
HRD54_RS03220	COG3719	Belongs to the RNase T2 family
HRD54_RS03225	COG0737	Belongs to the 5'-nucleotidase family
HRD54_RS03235	COG0419	ATPase involved in DNA repair
HRD54_RS03240	COG0420	3'-5' exonuclease activity
HRD54_RS03250	COG5002	protein histidine kinase activity
HRD54_RS03255	COG1114	Component of the transport system for branched-chain amino acids
HRD54_RS03290	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HRD54_RS03295	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS03305	COG2414	aldehyde ferredoxin oxidoreductase
HRD54_RS03310	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS03320	COG0450	alkyl hydroperoxide reductase
HRD54_RS03325	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HRD54_RS03330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRD54_RS03335	COG0343	queuine tRNA-ribosyltransferase activity
HRD54_RS03340	COG1862	Preprotein translocase
HRD54_RS03345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD54_RS03350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD54_RS03355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRD54_RS03360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD54_RS03360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD54_RS03365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRD54_RS03370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD54_RS03375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRD54_RS03380	COG2824	Alkylphosphonate utilization operon protein PhnA
HRD54_RS03385	COG1609	Transcriptional regulator
HRD54_RS03390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD54_RS03395	COG1879	ABC-type sugar transport system periplasmic component
HRD54_RS03400	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD54_RS03405	COG1129	ABC transporter
HRD54_RS03410	COG1869	D-ribose catabolic process
HRD54_RS03415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRD54_RS03420	COG0142	geranyltranstransferase activity
HRD54_RS03430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD54_RS03430	COG0301	tRNA thio-modification
HRD54_RS03445	COG0693	protein deglycase activity
HRD54_RS03450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HRD54_RS03455	COG1666	GTP binding
HRD54_RS03460	COG2814	Major facilitator Superfamily
HRD54_RS03465	COG0109	protoheme IX farnesyltransferase activity
HRD54_RS03470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRD54_RS03475	COG1845	cytochrome c oxidase, subunit III
HRD54_RS03480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD54_RS03485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRD54_RS03495	COG0513	Belongs to the DEAD box helicase family
HRD54_RS03500	COG2223	nitrite transmembrane transporter activity
HRD54_RS03505	COG3056	Lipoprotein
HRD54_RS03510	COG0271	Belongs to the BolA IbaG family
HRD54_RS03515	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD54_RS03520	COG0740	serine-type endopeptidase activity
HRD54_RS03525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRD54_RS03530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRD54_RS03535	COG0776	regulation of translation
HRD54_RS03540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD54_RS03545	COG1596	polysaccharide export
HRD54_RS03545	COG1555	photosystem II stabilization
HRD54_RS03550	COG0824	Thioesterase
HRD54_RS03555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD54_RS03560	COG1522	sequence-specific DNA binding
HRD54_RS03565	COG1132	(ABC) transporter
HRD54_RS03570	COG1132	(ABC) transporter
HRD54_RS03575	COG0347	Belongs to the P(II) protein family
HRD54_RS03580	COG0004	ammonium transporteR
HRD54_RS03585	COG1946	Acyl-CoA thioesterase
HRD54_RS03605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD54_RS03610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD54_RS03615	COG1309	transcriptional regulator
HRD54_RS03620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD54_RS03625	COG3264	Mechanosensitive ion channel
HRD54_RS03625	COG1196	nuclear chromosome segregation
HRD54_RS03640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRD54_RS03650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRD54_RS03655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRD54_RS03660	COG1966	Carbon starvation protein
HRD54_RS03665	COG2879	small protein
HRD54_RS03670	COG0523	cobalamin synthesis protein
HRD54_RS03680	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD54_RS03685	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD54_RS03695	COG0534	Mate efflux family protein
HRD54_RS03700	COG0673	inositol 2-dehydrogenase activity
HRD54_RS03705	COG5564	TIM-barrel signal transduction protein
HRD54_RS03710	COG5441	Belongs to the UPF0261 family
HRD54_RS03745	COG2132	Multicopper oxidase
HRD54_RS03755	COG0288	reversible hydration of carbon dioxide
HRD54_RS03760	COG1131	(ABC) transporter
HRD54_RS03765	COG0842	Transport permease protein
HRD54_RS03770	COG0477	Major facilitator Superfamily
HRD54_RS03780	COG0501	Belongs to the peptidase M48B family
HRD54_RS03795	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS03800	COG0243	molybdopterin cofactor binding
HRD54_RS03810	COG2837	iron assimilation
HRD54_RS03825	COG4633	Protein conserved in bacteria
HRD54_RS03835	COG2963	transposase activity
HRD54_RS03855	COG0754	glutathionylspermidine amidase activity
HRD54_RS03860	COG0583	DNA-binding transcription factor activity
HRD54_RS03865	COG2610	gluconate transmembrane transporter activity
HRD54_RS03870	COG3048	D-serine ammonia-lyase activity
HRD54_RS03875	COG3842	ATPase activity
HRD54_RS03885	COG1840	ABC-type Fe3 transport system, periplasmic component
HRD54_RS03890	COG2271	Major facilitator Superfamily
HRD54_RS03895	COG3851	Histidine kinase
HRD54_RS03905	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRD54_RS03910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRD54_RS03915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRD54_RS03920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRD54_RS03940	COG1489	DNA binding
HRD54_RS03945	COG1643	Atp-dependent helicase
HRD54_RS03950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD54_RS03955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD54_RS03960	COG0316	Belongs to the HesB IscA family
HRD54_RS03970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD54_RS03980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD54_RS03985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD54_RS03990	COG3956	TIGRFAM MazG family protein
HRD54_RS03995	COG0504	CTP synthase activity
HRD54_RS04000	COG0148	phosphopyruvate hydratase activity
HRD54_RS04005	COG0471	metal ion transport
HRD54_RS04010	COG3961	Belongs to the TPP enzyme family
HRD54_RS04015	COG0741	lytic transglycosylase activity
HRD54_RS04015	COG1388	LysM domain
HRD54_RS04020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD54_RS04025	COG2226	methyltransferase
HRD54_RS04030	COG0328	RNA-DNA hybrid ribonuclease activity
HRD54_RS04035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD54_RS04070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD54_RS04075	COG1120	ATPase activity
HRD54_RS04085	COG4264	IucA IucC family
HRD54_RS04095	COG0019	diaminopimelate decarboxylase activity
HRD54_RS04100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD54_RS04105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD54_RS04110	COG2814	Major facilitator Superfamily
HRD54_RS04125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRD54_RS04130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD54_RS04135	COG0126	phosphoglycerate kinase activity
HRD54_RS04145	COG2314	TM2 domain
HRD54_RS04150	COG3104	oligopeptide transport
HRD54_RS04165	COG1846	Transcriptional regulator
HRD54_RS04170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRD54_RS04185	COG1234	tRNA 3'-trailer cleavage
HRD54_RS04190	COG3539	Fimbrial protein
HRD54_RS04195	COG3188	usher protein
HRD54_RS04200	COG3121	Chaperone
HRD54_RS04205	COG3539	Fimbrial protein
HRD54_RS04210	COG3539	Fimbrial protein
HRD54_RS04230	COG0582	viral genome integration into host DNA
HRD54_RS04235	COG3539	Fimbrial protein
HRD54_RS04245	COG3188	usher protein
HRD54_RS04265	COG3539	Fimbrial protein
HRD54_RS04280	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HRD54_RS04290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD54_RS04295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD54_RS04350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD54_RS04355	COG1554	hydrolase, family 65, central catalytic
HRD54_RS04360	COG1263	PTS System
HRD54_RS04360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS04425	COG2207	Transcriptional regulator
HRD54_RS04425	COG3708	Transcriptional regulator
HRD54_RS04455	COG2274	protein secretion by the type I secretion system
HRD54_RS04465	COG1309	transcriptional regulator
HRD54_RS04470	COG0531	amino acid
HRD54_RS04475	COG1982	Orn Lys Arg decarboxylase major
HRD54_RS04505	COG0741	lytic transglycosylase activity
HRD54_RS04510	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HRD54_RS04515	COG1194	a g-specific adenine glycosylase
HRD54_RS04525	COG3171	Protein conserved in bacteria
HRD54_RS04530	COG2066	Belongs to the glutaminase family
HRD54_RS04540	COG4607	ABC-type enterochelin transport system periplasmic component
HRD54_RS04545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD54_RS04550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRD54_RS04555	COG0762	integral membrane protein
HRD54_RS04560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRD54_RS04565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRD54_RS04570	COG2805	Type II/IV secretion system protein
HRD54_RS04575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRD54_RS04580	COG1678	Uncharacterized ACR, COG1678
HRD54_RS04585	COG0189	ligase activity
HRD54_RS04590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRD54_RS04610	COG0583	DNA-binding transcription factor activity
HRD54_RS04615	COG0583	DNA-binding transcription factor activity
HRD54_RS04625	COG1960	acyl-CoA dehydrogenase activity
HRD54_RS04630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRD54_RS04635	COG0121	glutamine amidotransferase
HRD54_RS04640	COG3034	peptidoglycan biosynthetic process
HRD54_RS04645	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD54_RS04650	COG1805	sodium ion transport
HRD54_RS04655	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD54_RS04660	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD54_RS04665	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD54_RS04670	COG2871	sodium ion transport
HRD54_RS04675	COG1477	protein flavinylation
HRD54_RS04680	COG2991	Protein conserved in bacteria
HRD54_RS04685	COG3237	CsbD-like
HRD54_RS04695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD54_RS04700	COG4774	siderophore transport
HRD54_RS04705	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD54_RS04710	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HRD54_RS04725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRD54_RS04730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRD54_RS04735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD54_RS04740	COG0318	PFAM AMP-dependent synthetase and ligase
HRD54_RS04740	COG0204	Acyl-transferase
HRD54_RS04745	COG2814	Major facilitator Superfamily
HRD54_RS04750	COG1546	Belongs to the CinA family
HRD54_RS04755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRD54_RS04760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD54_RS04765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRD54_RS04795	COG2918	glutathione biosynthetic process
HRD54_RS04800	COG1854	S-ribosylhomocysteine lyase activity
HRD54_RS04805	COG4536	flavin adenine dinucleotide binding
HRD54_RS04810	COG4137	Cytochrome C assembly protein
HRD54_RS04815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRD54_RS04820	COG0228	four-way junction DNA binding
HRD54_RS04830	COG0336	Belongs to the RNA methyltransferase TrmD family
HRD54_RS04835	COG0335	large ribosomal subunit rRNA binding
HRD54_RS04840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD54_RS04845	COG1605	Chorismate mutase
HRD54_RS04845	COG0287	Prephenate dehydrogenase
HRD54_RS04860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD54_RS04865	COG0077	Prephenate dehydratase
HRD54_RS04865	COG1605	Chorismate mutase
HRD54_RS04870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD54_RS04875	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD54_RS04880	COG0564	pseudouridine synthase activity
HRD54_RS04890	COG0542	response to heat
HRD54_RS04920	COG5544	Lipoprotein
HRD54_RS04925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD54_RS04930	COG1042	CoA-binding domain protein
HRD54_RS04930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD54_RS04930	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD54_RS04940	COG5160	protein modification by small protein removal
HRD54_RS04945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD54_RS04950	COG2814	Major facilitator Superfamily
HRD54_RS04955	COG1566	PFAM secretion protein HlyD family protein
HRD54_RS04965	COG2814	Major facilitator Superfamily
HRD54_RS04970	COG1335	isochorismatase
HRD54_RS04975	COG1846	Transcriptional regulator
HRD54_RS04980	COG2814	Major facilitator Superfamily
HRD54_RS04985	COG1629	transport
HRD54_RS04990	COG2113	Glycine betaine
HRD54_RS04995	COG4176	ABC-type proline glycine betaine transport system permease component
HRD54_RS05000	COG4175	Glycine betaine
HRD54_RS05015	COG1780	Probably involved in ribonucleotide reductase function
HRD54_RS05040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRD54_RS05045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRD54_RS05050	COG0321	lipoyl(octanoyl) transferase activity
HRD54_RS05060	COG1686	Belongs to the peptidase S11 family
HRD54_RS05065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD54_RS05070	COG0772	Belongs to the SEDS family
HRD54_RS05075	COG0768	penicillin binding
HRD54_RS05080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HRD54_RS05085	COG0799	negative regulation of ribosome biogenesis
HRD54_RS05095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRD54_RS05100	COG1466	dna polymerase III delta subunit
HRD54_RS05105	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HRD54_RS05110	COG0495	leucyl-tRNA aminoacylation
HRD54_RS05115	COG1126	abc transporter atp-binding protein
HRD54_RS05120	COG0765	amino acid transport
HRD54_RS05125	COG0765	amino acid transport
HRD54_RS05150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD54_RS05160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRD54_RS05170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRD54_RS05175	COG1702	phosphate starvation-inducible protein PhoH
HRD54_RS05180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD54_RS05185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD54_RS05190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRD54_RS05240	COG1940	carbohydrate kinase activity
HRD54_RS05240	COG1846	Transcriptional regulator
HRD54_RS05245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD54_RS05250	COG0363	glucosamine-6-phosphate deaminase activity
HRD54_RS05260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD54_RS05275	COG0735	belongs to the Fur family
HRD54_RS05280	COG0716	FMN binding
HRD54_RS05290	COG0596	Alpha beta hydrolase
HRD54_RS05295	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HRD54_RS05300	COG0033	Phosphoglucomutase
HRD54_RS05305	COG4807	Protein conserved in bacteria
HRD54_RS05310	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HRD54_RS05325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRD54_RS05335	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRD54_RS05340	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRD54_RS05345	COG0714	Associated with various cellular activities
HRD54_RS05355	COG2814	Major facilitator Superfamily
HRD54_RS05375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HRD54_RS05380	COG1053	succinate dehydrogenase
HRD54_RS05390	COG0567	Dehydrogenase, E1 component
HRD54_RS05395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD54_RS05400	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD54_RS05405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD54_RS05410	COG1271	oxidase subunit
HRD54_RS05415	COG1294	oxidase, subunit
HRD54_RS05420	COG4890	Cyd operon protein YbgT
HRD54_RS05425	COG3790	cyd operon protein YbgE
HRD54_RS05430	COG0583	DNA-binding transcription factor activity
HRD54_RS05435	COG0477	Major facilitator Superfamily
HRD54_RS05445	COG0824	Thioesterase
HRD54_RS05450	COG0811	peptide transport
HRD54_RS05455	COG0848	biopolymer transport protein
HRD54_RS05460	COG3064	Membrane
HRD54_RS05465	COG0823	Involved in the tonB-independent uptake of proteins
HRD54_RS05470	COG2885	chlorophyll binding
HRD54_RS05475	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HRD54_RS05500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD54_RS05505	COG0588	phosphoglycerate mutase activity
HRD54_RS05510	COG1119	ATPase activity
HRD54_RS05515	COG2831	hemolysin activation secretion protein
HRD54_RS05530	COG2005	Transcriptional regulator
HRD54_RS05530	COG3585	molybdate ion transport
HRD54_RS05540	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRD54_RS05545	COG4149	molybdate abc transporter
HRD54_RS05550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HRD54_RS05555	COG0561	phosphatase activity
HRD54_RS05560	COG2706	6-phosphogluconolactonase activity
HRD54_RS05570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD54_RS05575	COG0156	8-amino-7-oxononanoate synthase activity
HRD54_RS05580	COG2226	methyltransferase
HRD54_RS05585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRD54_RS05590	COG0556	nucleotide-excision repair
HRD54_RS05600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD54_RS05605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRD54_RS05610	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD54_RS05615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRD54_RS05620	COG0314	molybdopterin synthase activity
HRD54_RS05625	COG0670	Belongs to the BI1 family
HRD54_RS05630	COG0842	Transport permease protein
HRD54_RS05635	COG0842	Transport permease protein
HRD54_RS05640	COG1131	(ABC) transporter
HRD54_RS05650	COG1309	transcriptional regulator
HRD54_RS05655	COG0513	Belongs to the DEAD box helicase family
HRD54_RS05660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD54_RS05670	COG2897	thiosulfate sulfurtransferase activity
HRD54_RS05680	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD54_RS05695	COG2079	MmgE PrpD family protein
HRD54_RS05700	COG0583	DNA-binding transcription factor activity
HRD54_RS05735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD54_RS05745	COG0477	Major facilitator Superfamily
HRD54_RS05750	COG0302	gtp cyclohydrolase
HRD54_RS05755	COG2311	Membrane
HRD54_RS05760	COG2949	membrane
HRD54_RS05765	COG0281	malic enzyme
HRD54_RS05770	COG0295	cytidine deaminase activity
HRD54_RS05775	COG1346	cytolysis
HRD54_RS05780	COG1380	Effector of murein hydrolase LrgA
HRD54_RS05785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD54_RS05785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD54_RS05790	COG0489	protein tyrosine kinase activity
HRD54_RS05795	COG0572	uridine kinase
HRD54_RS05800	COG0717	Belongs to the dCTP deaminase family
HRD54_RS05805	COG2982	Protein involved in outer membrane biogenesis
HRD54_RS05810	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD54_RS05815	COG1253	flavin adenine dinucleotide binding
HRD54_RS05825	COG0675	Transposase, IS605 OrfB family
HRD54_RS05830	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRD54_RS05835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD54_RS05840	COG1454	alcohol dehydrogenase
HRD54_RS05845	COG0140	phosphoribosyl-ATP diphosphatase activity
HRD54_RS05845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRD54_RS05850	COG0107	imidazoleglycerol-phosphate synthase activity
HRD54_RS05855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRD54_RS05860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRD54_RS05865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD54_RS05865	COG0131	Imidazoleglycerol-phosphate dehydratase
HRD54_RS05875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRD54_RS05880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRD54_RS05885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD54_RS05890	COG0625	glutathione transferase activity
HRD54_RS05895	COG1686	Belongs to the peptidase S11 family
HRD54_RS05900	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRD54_RS05905	COG1760	l-serine dehydratase
HRD54_RS05910	COG0814	amino acid
HRD54_RS05915	COG0671	phosphoesterase, PA-phosphatase related
HRD54_RS05920	COG0432	Pfam Uncharacterised protein family UPF0047
HRD54_RS05925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD54_RS05940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD54_RS05945	COG4160	amino acid transport
HRD54_RS05950	COG4215	(ABC) transporter
HRD54_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD54_RS05960	COG1126	abc transporter atp-binding protein
HRD54_RS05965	COG0702	epimerase
HRD54_RS05970	COG2431	L-lysine efflux transmembrane transporter activity
HRD54_RS05975	COG3593	DNA synthesis involved in DNA repair
HRD54_RS05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD54_RS05985	COG1136	(ABC) transporter
HRD54_RS05985	COG0577	efflux transmembrane transporter activity
HRD54_RS05990	COG1278	Cold shock
HRD54_RS05995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRD54_RS06000	COG0542	response to heat
HRD54_RS06005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD54_RS06010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRD54_RS06015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HRD54_RS06025	COG0492	ferredoxin-NADP+ reductase activity
HRD54_RS06035	COG3107	peptidoglycan biosynthetic process
HRD54_RS06035	COG1674	ftsk spoiiie
HRD54_RS06040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRD54_RS06045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRD54_RS06050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRD54_RS06060	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HRD54_RS06070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD54_RS06075	COG1882	Formate acetyltransferase
HRD54_RS06080	COG2116	formate transmembrane transporter activity
HRD54_RS06085	COG1944	ATP diphosphatase activity
HRD54_RS06090	COG0252	asparaginase activity
HRD54_RS06095	COG3210	domain, Protein
HRD54_RS06105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRD54_RS06110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD54_RS06115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRD54_RS06120	COG0539	negative regulation of cytoplasmic translation
HRD54_RS06125	COG0776	regulation of translation
HRD54_RS06130	COG0658	competence protein
HRD54_RS06130	COG2333	competence protein COMEC
HRD54_RS06135	COG1132	(ABC) transporter
HRD54_RS06140	COG1663	tetraacyldisaccharide 4'-kinase activity
HRD54_RS06150	COG2835	tetraacyldisaccharide 4'-kinase activity
HRD54_RS06155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRD54_RS06160	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRD54_RS06165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD54_RS06170	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HRD54_RS06175	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HRD54_RS06180	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRD54_RS06190	COG3700	Belongs to the class B bacterial acid phosphatase family
HRD54_RS06195	COG2989	Protein conserved in bacteria
HRD54_RS06200	COG3108	Peptidase M15
HRD54_RS06205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD54_RS06210	COG3157	Type VI secretion system effector, Hcp
HRD54_RS06300	COG3501	Rhs element vgr protein
HRD54_RS06400	COG1448	Aminotransferase
HRD54_RS06405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HRD54_RS06410	COG0017	Asparaginyl-tRNA synthetase
HRD54_RS06420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRD54_RS06425	COG0308	aminopeptidase N
HRD54_RS06435	COG0167	dihydroorotate dehydrogenase activity
HRD54_RS06445	COG0633	Ferredoxin
HRD54_RS06445	COG3217	Mosc domain protein beta barrel domain protein
HRD54_RS06450	COG0116	Belongs to the methyltransferase superfamily
HRD54_RS06450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD54_RS06455	COG0488	(ABC) transporter
HRD54_RS06460	COG2995	paraquat-inducible protein a
HRD54_RS06465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD54_RS06465	COG3008	intermembrane lipid transfer
HRD54_RS06470	COG3009	Protein conserved in bacteria
HRD54_RS06480	COG3130	regulation of translation
HRD54_RS06485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD54_RS06490	COG1067	ATP-dependent peptidase activity
HRD54_RS06495	COG3120	sequence-specific DNA binding
HRD54_RS06500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HRD54_RS06500	COG2885	chlorophyll binding
HRD54_RS06510	COG3070	regulator of competence-specific genes
HRD54_RS06515	COG1289	transmembrane transporter activity
HRD54_RS06520	COG0210	DNA helicase
HRD54_RS06525	COG1803	Methylglyoxal synthase
HRD54_RS06530	COG1832	CoA-binding protein
HRD54_RS06535	COG3785	DNA binding
HRD54_RS06540	COG1254	Belongs to the acylphosphatase family
HRD54_RS06545	COG2920	part of a sulfur-relay system
HRD54_RS06555	COG0456	acetyltransferase
HRD54_RS06565	COG3615	Tellurite resistance protein tehB
HRD54_RS06580	COG0583	DNA-binding transcription factor activity
HRD54_RS06585	COG0656	L-ascorbic acid biosynthetic process
HRD54_RS06595	COG3708	Transcriptional regulator
HRD54_RS06595	COG2207	Transcriptional regulator
HRD54_RS06610	COG1278	Cold shock
HRD54_RS06615	COG1560	Kdo2-lipid A biosynthetic process
HRD54_RS06640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HRD54_RS06650	COG1280	lysine exporter protein (LysE YggA)
HRD54_RS06660	COG3083	sulfuric ester hydrolase activity
HRD54_RS06665	COG3082	Protein of unknown function (DUF1414)
HRD54_RS06670	COG3081	Nucleoid-associated protein
HRD54_RS06675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRD54_RS06680	COG1061	Type III restriction enzyme res subunit
HRD54_RS06685	COG1187	pseudouridine synthase activity
HRD54_RS06690	COG2814	Major facilitator Superfamily
HRD54_RS06700	COG0791	NLP P60 protein
HRD54_RS06705	COG0671	phosphoesterase, PA-phosphatase related
HRD54_RS06720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD54_RS06730	COG0494	nUDIX hydrolase
HRD54_RS06735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRD54_RS06740	COG2855	membrane
HRD54_RS06745	COG0583	DNA-binding transcription factor activity
HRD54_RS06750	COG0833	amino acid
HRD54_RS06755	COG4771	TonB-dependent receptor
HRD54_RS06760	COG0531	amino acid
HRD54_RS06770	COG3961	Belongs to the TPP enzyme family
HRD54_RS06775	COG0583	DNA-binding transcription factor activity
HRD54_RS06780	COG0277	FAD linked oxidase domain protein
HRD54_RS06785	COG2925	Exonuclease
HRD54_RS06790	COG2211	Major facilitator Superfamily
HRD54_RS06795	COG2926	Belongs to the UPF0265 family
HRD54_RS06800	COG1530	ribonuclease E activity
HRD54_RS06805	COG0564	pseudouridine synthase activity
HRD54_RS06815	COG0424	maF-like protein
HRD54_RS06820	COG1399	metal-binding, possibly nucleic acid-binding protein
HRD54_RS06825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRD54_RS06830	COG0416	fatty acid biosynthetic process
HRD54_RS06835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRD54_RS06850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD54_RS06855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD54_RS06860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD54_RS06865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRD54_RS06870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRD54_RS06875	COG0470	DNA polymerase III
HRD54_RS06880	COG0084	hydrolase, TatD family'
HRD54_RS06885	COG0537	adenosine 5'-monophosphoramidase activity
HRD54_RS06890	COG5633	Lipoprotein
HRD54_RS06895	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HRD54_RS06905	COG1472	Belongs to the glycosyl hydrolase 3 family
HRD54_RS06915	COG1252	NADH dehydrogenase
HRD54_RS06920	COG3134	Outer membrane lipoprotein
HRD54_RS06925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRD54_RS06930	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD54_RS06940	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD54_RS06955	COG2850	peptidyl-arginine hydroxylation
HRD54_RS06960	COG2205	protein histidine kinase activity
HRD54_RS06965	COG0745	RESPONSE REGULATOR receiver
HRD54_RS06970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD54_RS06975	COG2915	High frequency lysogenization protein hflD homolog
HRD54_RS06980	COG0482	sulfurtransferase activity
HRD54_RS06990	COG1187	pseudouridine synthase activity
HRD54_RS06995	COG0538	isocitrate dehydrogenase activity
HRD54_RS07000	COG0582	viral genome integration into host DNA
HRD54_RS07010	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD54_RS07040	COG1846	Transcriptional regulator
HRD54_RS07050	COG1403	HNH endonuclease
HRD54_RS07070	COG1278	Cold shock
HRD54_RS07075	COG3477	response to acidic pH
HRD54_RS07080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD54_RS07085	COG4977	sequence-specific DNA binding
HRD54_RS07085	COG1917	Cupin 2, conserved barrel domain protein
HRD54_RS07105	COG3772	lysozyme
HRD54_RS07135	COG1802	Transcriptional regulator
HRD54_RS07135	COG4626	Terminase
HRD54_RS07240	COG0538	isocitrate dehydrogenase activity
HRD54_RS07260	COG1278	Cold shock
HRD54_RS07265	COG0071	Belongs to the small heat shock protein (HSP20) family
HRD54_RS07275	COG1733	regulation of RNA biosynthetic process
HRD54_RS07280	COG0702	epimerase
HRD54_RS07290	COG0572	uridine kinase
HRD54_RS07300	COG1475	DNA binding
HRD54_RS07305	COG3969	phosphoadenosine phosphosulfate
HRD54_RS07310	COG0500	methyltransferase
HRD54_RS07325	COG3272	Protein of unknown function (DUF1722)
HRD54_RS07335	COG2841	Protein conserved in bacteria
HRD54_RS07365	COG0024	Methionine aminopeptidase
HRD54_RS07375	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HRD54_RS07380	COG1598	PFAM Uncharacterised protein family UPF0150
HRD54_RS07385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HRD54_RS07405	COG1528	Iron-storage protein
HRD54_RS07410	COG2372	response to copper ion
HRD54_RS07415	COG1276	copper resistance
HRD54_RS07430	COG3008	intermembrane lipid transfer
HRD54_RS07435	COG2995	paraquat-inducible protein a
HRD54_RS07440	COG1956	GAF domain-containing protein
HRD54_RS07445	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HRD54_RS07460	COG0501	Belongs to the peptidase M48B family
HRD54_RS07475	COG1988	membrane-bound metal-dependent
HRD54_RS07480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD54_RS07490	COG3001	Fructosamine kinase
HRD54_RS07495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD54_RS07500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD54_RS07505	COG1121	(ABC) transporter
HRD54_RS07510	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD54_RS07530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD54_RS07540	COG3539	Fimbrial protein
HRD54_RS07545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRD54_RS07550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRD54_RS07555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRD54_RS07560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRD54_RS07570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRD54_RS07575	COG0072	phenylalanine-tRNA ligase activity
HRD54_RS07575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD54_RS07580	COG0776	regulation of translation
HRD54_RS07585	COG4139	cobalamin transport
HRD54_RS07590	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HRD54_RS07595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD54_RS07600	COG0463	Glycosyl transferase, family 2
HRD54_RS07605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD54_RS07605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD54_RS07610	COG0726	polysaccharide deacetylase
HRD54_RS07615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD54_RS07620	COG2076	Multidrug Resistance protein
HRD54_RS07625	COG2076	Multidrug Resistance protein
HRD54_RS07630	COG0791	NLP P60 protein
HRD54_RS07635	COG0095	Lipoate-protein ligase
HRD54_RS07640	COG2207	Transcriptional regulator
HRD54_RS07645	COG0579	oxidoreductase
HRD54_RS07650	COG2186	Transcriptional regulator
HRD54_RS07665	COG0586	Pfam SNARE associated Golgi protein
HRD54_RS07730	COG0012	GTP binding
HRD54_RS07735	COG0193	aminoacyl-tRNA hydrolase activity
HRD54_RS07745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRD54_RS07750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRD54_RS07755	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HRD54_RS07760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRD54_RS07765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRD54_RS07775	COG2912	Transglutaminase-like superfamily
HRD54_RS07780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRD54_RS07785	COG1242	4 iron, 4 sulfur cluster binding
HRD54_RS07795	COG0659	secondary active sulfate transmembrane transporter activity
HRD54_RS07805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD54_RS07820	COG3381	protein complex oligomerization
HRD54_RS07830	COG0477	Major facilitator Superfamily
HRD54_RS07835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD54_RS07840	COG0728	peptidoglycan biosynthetic process
HRD54_RS07850	COG0018	arginyl-trna synthetase
HRD54_RS07855	COG3102	Protein conserved in bacteria
HRD54_RS07860	COG3142	Participates in the control of copper homeostasis
HRD54_RS07870	COG0488	(ABC) transporter
HRD54_RS07875	COG0500	methyltransferase
HRD54_RS07880	COG2226	methyltransferase
HRD54_RS07885	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRD54_RS07890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRD54_RS07895	COG0494	nUDIX hydrolase
HRD54_RS07900	COG0217	transcriptional regulatory protein
HRD54_RS07905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRD54_RS07910	COG0632	four-way junction helicase activity
HRD54_RS07915	COG2255	four-way junction helicase activity
HRD54_RS07925	COG3501	Rhs element vgr protein
HRD54_RS07940	COG3209	COG3209 Rhs family protein
HRD54_RS07980	COG3209	COG3209 Rhs family protein
HRD54_RS08005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD54_RS08010	COG1121	(ABC) transporter
HRD54_RS08015	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HRD54_RS08020	COG0739	heme binding
HRD54_RS08025	COG1560	Kdo2-lipid A biosynthetic process
HRD54_RS08030	COG0469	pyruvate kinase activity
HRD54_RS08035	COG1737	Transcriptional regulator
HRD54_RS08040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRD54_RS08045	COG2076	Multidrug Resistance protein
HRD54_RS08050	COG2076	Multidrug Resistance protein
HRD54_RS08055	COG0702	epimerase
HRD54_RS08060	COG0251	oxidation-reduction process
HRD54_RS08065	COG1199	ATP-dependent helicase activity
HRD54_RS08075	COG3065	identical protein binding
HRD54_RS08080	COG0318	PFAM AMP-dependent synthetase and ligase
HRD54_RS08085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRD54_RS08090	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRD54_RS08095	COG2894	cell division
HRD54_RS08100	COG0850	regulation of cytokinetic process
HRD54_RS08105	COG3100	YcgL domain-containing protein
HRD54_RS08110	COG2951	lytic endotransglycosylase activity
HRD54_RS08115	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD54_RS08120	COG2983	Belongs to the UPF0260 family
HRD54_RS08125	COG0390	transport system, permease component
HRD54_RS08130	COG4619	ABC transporter
HRD54_RS08140	COG2207	Transcriptional regulator
HRD54_RS08140	COG3708	Transcriptional regulator
HRD54_RS08155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD54_RS08160	COG2911	Protein conserved in bacteria
HRD54_RS08170	COG3784	Protein of unknown function (DUF1318)
HRD54_RS08195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRD54_RS08210	COG1643	Atp-dependent helicase
HRD54_RS08225	COG3188	usher protein
HRD54_RS08230	COG3121	Chaperone
HRD54_RS08240	COG0531	amino acid
HRD54_RS08250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRD54_RS08255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRD54_RS08260	COG0589	response to stress
HRD54_RS08265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD54_RS08270	COG0243	molybdopterin cofactor binding
HRD54_RS08275	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS08290	COG0604	alcohol dehydrogenase
HRD54_RS08290	COG3321	synthase
HRD54_RS08300	COG1695	Transcriptional regulator
HRD54_RS08320	COG3634	alkyl hydroperoxide reductase activity
HRD54_RS08325	COG4974	Belongs to the 'phage' integrase family
HRD54_RS08395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD54_RS08400	COG4974	Belongs to the 'phage' integrase family
HRD54_RS08410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD54_RS08415	COG1129	ABC transporter
HRD54_RS08415	COG0842	Transport permease protein
HRD54_RS08420	COG0842	Transport permease protein
HRD54_RS08425	COG0745	RESPONSE REGULATOR receiver
HRD54_RS08430	COG2205	protein histidine kinase activity
HRD54_RS08435	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD54_RS08440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD54_RS08445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD54_RS08450	COG0666	response to abiotic stimulus
HRD54_RS08455	COG0590	tRNA wobble adenosine to inosine editing
HRD54_RS08460	COG3381	protein complex oligomerization
HRD54_RS08465	COG3302	dmso reductase anchor subunit
HRD54_RS08470	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS08475	COG0243	molybdopterin cofactor binding
HRD54_RS08480	COG1349	DNA-binding transcription factor activity
HRD54_RS08500	COG2376	Dihydroxyacetone kinase
HRD54_RS08510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD54_RS08520	COG0251	oxidation-reduction process
HRD54_RS08540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HRD54_RS08545	COG2169	Transcriptional regulator
HRD54_RS08545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD54_RS08560	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRD54_RS08580	COG1464	Belongs to the NlpA lipoprotein family
HRD54_RS08600	COG2814	Major facilitator Superfamily
HRD54_RS08610	COG0583	DNA-binding transcription factor activity
HRD54_RS08620	COG1309	transcriptional regulator
HRD54_RS08630	COG0488	(ABC) transporter
HRD54_RS08635	COG1671	Belongs to the UPF0178 family
HRD54_RS08640	COG0402	S-adenosylhomocysteine deaminase activity
HRD54_RS08650	COG2814	Major facilitator Superfamily
HRD54_RS08660	COG0477	Major facilitator Superfamily
HRD54_RS08665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HRD54_RS08680	COG1289	transmembrane transporter activity
HRD54_RS08685	COG1538	Outer membrane efflux protein
HRD54_RS08695	COG0443	Heat shock 70 kDa protein
HRD54_RS08715	COG1070	Carbohydrate kinase
HRD54_RS08720	COG2115	Belongs to the xylose isomerase family
HRD54_RS08725	COG1757	Na H antiporter
HRD54_RS08730	COG0436	Aminotransferase
HRD54_RS08735	COG1609	Transcriptional regulator
HRD54_RS08735	COG2207	Transcriptional regulator
HRD54_RS08740	COG4628	conserved protein (DUF2132)
HRD54_RS08805	COG4221	oxidoreductase activity
HRD54_RS08820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRD54_RS08825	COG1940	carbohydrate kinase activity
HRD54_RS08830	COG0583	DNA-binding transcription factor activity
HRD54_RS08835	COG2814	Major facilitator Superfamily
HRD54_RS08845	COG0114	fumarate hydratase activity
HRD54_RS08850	COG5339	Protein conserved in bacteria
HRD54_RS08860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD54_RS08865	COG0385	Bile acid
HRD54_RS08870	COG0673	inositol 2-dehydrogenase activity
HRD54_RS08880	COG4657	Part of a membrane complex involved in electron transport
HRD54_RS08890	COG4656	Part of a membrane complex involved in electron transport
HRD54_RS08900	COG4659	FMN binding
HRD54_RS08910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRD54_RS08915	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRD54_RS08920	COG0023	Translation Initiation Factor
HRD54_RS08925	COG0284	orotidine-5'-phosphate decarboxylase activity
HRD54_RS08930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HRD54_RS08935	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HRD54_RS08940	COG0671	phosphoesterase, PA-phosphatase related
HRD54_RS08945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD54_RS08960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRD54_RS08970	COG0583	DNA-binding transcription factor activity
HRD54_RS08995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD54_RS09005	COG0616	signal peptide processing
HRD54_RS09010	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS09025	COG1187	pseudouridine synthase activity
HRD54_RS09030	COG0009	L-threonylcarbamoyladenylate synthase
HRD54_RS09040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRD54_RS09045	COG0512	Glutamine amidotransferase of anthranilate synthase
HRD54_RS09050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD54_RS09060	COG0133	tryptophan synthase activity
HRD54_RS09065	COG0159	tryptophan synthase activity
HRD54_RS09075	COG3047	cAMP biosynthetic process
HRD54_RS09090	COG2917	probably involved in intracellular septation
HRD54_RS09110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD54_RS09125	COG0346	lactoylglutathione lyase activity
HRD54_RS09145	COG0598	Magnesium transport protein CorA
HRD54_RS09160	COG4166	transmembrane transport
HRD54_RS09165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRD54_RS09180	COG3768	UPF0283 membrane protein
HRD54_RS09185	COG3106	COG3106 Predicted ATPase
HRD54_RS09195	COG1983	PspC domain protein
HRD54_RS09205	COG1842	Phage shock protein A
HRD54_RS09210	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HRD54_RS09215	COG4166	transmembrane transport
HRD54_RS09225	COG4171	peptide transport system, permease
HRD54_RS09230	COG4172	Belongs to the ABC transporter superfamily
HRD54_RS09240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD54_RS09255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRD54_RS09260	COG0259	pyridoxamine-phosphate oxidase activity
HRD54_RS09265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRD54_RS09280	COG3313	Fe-S protein
HRD54_RS09285	COG0346	lactoylglutathione lyase activity
HRD54_RS09290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD54_RS09295	COG0675	Transposase, IS605 OrfB family
HRD54_RS09305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRD54_RS09310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRD54_RS09325	COG0730	response to heat
HRD54_RS09340	COG1609	Transcriptional regulator
HRD54_RS09345	COG0583	DNA-binding transcription factor activity
HRD54_RS09350	COG2814	Major facilitator Superfamily
HRD54_RS09355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD54_RS09360	COG0307	riboflavin synthase, alpha
HRD54_RS09365	COG0534	Mate efflux family protein
HRD54_RS09385	COG0531	amino acid
HRD54_RS09390	COG0076	glutamate decarboxylase activity
HRD54_RS09405	COG1388	LysM domain
HRD54_RS09405	COG1376	ErfK ybiS ycfS ynhG family protein
HRD54_RS09410	COG2166	iron-sulfur cluster assembly
HRD54_RS09415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD54_RS09420	COG0719	Fe-S assembly protein
HRD54_RS09425	COG0396	ATPase activity
HRD54_RS09430	COG0719	Fe-S assembly protein
HRD54_RS09435	COG0316	Belongs to the HesB IscA family
HRD54_RS09445	COG2050	protein possibly involved in aromatic compounds catabolism
HRD54_RS09450	COG0277	FAD linked oxidase domain protein
HRD54_RS09450	COG0247	lactate metabolic process
HRD54_RS09455	COG0628	permease
HRD54_RS09460	COG0574	Belongs to the PEP-utilizing enzyme family
HRD54_RS09460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD54_RS09465	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRD54_RS09470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD54_RS09485	COG4771	TonB-dependent receptor
HRD54_RS09490	COG3720	iron ion transport
HRD54_RS09495	COG4558	Periplasmic binding protein
HRD54_RS09500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD54_RS09505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD54_RS09515	COG1280	lysine exporter protein (LysE YggA)
HRD54_RS09520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD54_RS09525	COG1271	oxidase subunit
HRD54_RS09530	COG1294	oxidase, subunit
HRD54_RS09545	COG3152	Membrane
HRD54_RS09550	COG1702	phosphate starvation-inducible protein PhoH
HRD54_RS09560	COG2356	endonuclease I
HRD54_RS09570	COG3610	response to peptide
HRD54_RS09575	COG2966	Psort location CytoplasmicMembrane, score
HRD54_RS09600	COG0589	response to stress
HRD54_RS09610	COG0589	response to stress
HRD54_RS09630	COG0113	porphobilinogen synthase activity
HRD54_RS09640	COG0402	S-adenosylhomocysteine deaminase activity
HRD54_RS09645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HRD54_RS09650	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HRD54_RS09655	COG1012	belongs to the aldehyde dehydrogenase family
HRD54_RS09660	COG1309	transcriptional regulator
HRD54_RS09665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRD54_RS09670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD54_RS09685	COG3188	usher protein
HRD54_RS09695	COG3539	Fimbrial protein
HRD54_RS09705	COG1396	sequence-specific DNA binding
HRD54_RS09715	COG0444	Belongs to the ABC transporter superfamily
HRD54_RS09720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD54_RS09750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD54_RS09755	COG4166	transmembrane transport
HRD54_RS09760	COG0601	transmembrane transport
HRD54_RS09765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD54_RS09775	COG4608	Belongs to the ABC transporter superfamily
HRD54_RS09780	COG2095	MarC family integral membrane protein
HRD54_RS09785	COG1454	alcohol dehydrogenase
HRD54_RS09785	COG1012	belongs to the aldehyde dehydrogenase family
HRD54_RS09790	COG1435	thymidine kinase activity
HRD54_RS09805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD54_RS09810	COG0745	RESPONSE REGULATOR receiver
HRD54_RS09815	COG3012	SEC-C Motif Domain Protein
HRD54_RS09820	COG0788	formyltetrahydrofolate deformylase activity
HRD54_RS09830	COG0583	DNA-binding transcription factor activity
HRD54_RS09835	COG0708	Exodeoxyribonuclease III
HRD54_RS09840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD54_RS09845	COG0709	Synthesizes selenophosphate from selenide and ATP
HRD54_RS09850	COG0778	Nitroreductase
HRD54_RS09855	COG0616	signal peptide processing
HRD54_RS09860	COG0252	asparaginase activity
HRD54_RS09865	COG1335	isochorismatase
HRD54_RS09870	COG3139	Protein of unknown function (DUF1315)
HRD54_RS09875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD54_RS09890	COG3713	MltA-interacting MipA family protein
HRD54_RS09895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRD54_RS09900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRD54_RS09905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD54_RS09910	COG2186	Transcriptional regulator
HRD54_RS09915	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD54_RS09920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HRD54_RS09930	COG2076	Multidrug Resistance protein
HRD54_RS09950	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD54_RS09955	COG3683	transport system, periplasmic component
HRD54_RS09985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRD54_RS09990	COG0322	excinuclease ABC activity
HRD54_RS09995	COG2197	response regulator
HRD54_RS10000	COG0778	Nitroreductase
HRD54_RS10005	COG1494	fructose-1,6-bisphosphatase
HRD54_RS10010	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HRD54_RS10025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD54_RS10070	COG3842	ATPase activity
HRD54_RS10075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRD54_RS10080	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRD54_RS10085	COG2390	Transcriptional regulator
HRD54_RS10090	COG1324	tolerance protein
HRD54_RS10105	COG3541	Predicted nucleotidyltransferase
HRD54_RS10195	COG2246	polysaccharide biosynthetic process
HRD54_RS10285	COG1783	phage Terminase large subunit
HRD54_RS10315	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HRD54_RS10400	COG0582	viral genome integration into host DNA
HRD54_RS10405	COG0519	Catalyzes the synthesis of GMP from XMP
HRD54_RS10405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRD54_RS10410	COG0517	IMP dehydrogenase activity
HRD54_RS10410	COG0516	GMP reductase activity
HRD54_RS10415	COG1570	exodeoxyribonuclease VII activity
HRD54_RS10420	COG1629	transport
HRD54_RS10420	COG4206	TonB-dependent receptor
HRD54_RS10425	COG1770	oligopeptidase
HRD54_RS10440	COG0280	phosphate acetyltransferase
HRD54_RS10440	COG0281	malic enzyme
HRD54_RS10445	COG2197	response regulator
HRD54_RS10455	COG1393	Belongs to the ArsC family
HRD54_RS10460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD54_RS10465	COG1876	peptidase activity
HRD54_RS10475	COG0675	Transposase, IS605 OrfB family
HRD54_RS10480	COG2832	Protein of unknown function (DUF454)
HRD54_RS10490	COG1444	tRNA N-acetyltransferase activity
HRD54_RS10495	COG2707	UPF0756 membrane protein
HRD54_RS10500	COG2321	neutral zinc metallopeptidase
HRD54_RS10505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRD54_RS10510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HRD54_RS10515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD54_RS10520	COG2716	regulation of RNA biosynthetic process
HRD54_RS10525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRD54_RS10530	COG0628	permease
HRD54_RS10535	COG4783	chaperone-mediated protein folding
HRD54_RS10540	COG1393	Belongs to the ArsC family
HRD54_RS10545	COG2211	Major facilitator Superfamily
HRD54_RS10550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD54_RS10555	COG0668	transmembrane transport
HRD54_RS10560	COG2233	PERMEase
HRD54_RS10565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRD54_RS10570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRD54_RS10575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRD54_RS10580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD54_RS10585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRD54_RS10595	COG2239	Acts as a magnesium transporter
HRD54_RS10620	COG3104	oligopeptide transport
HRD54_RS10625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD54_RS10630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD54_RS10635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD54_RS10640	COG2205	protein histidine kinase activity
HRD54_RS10645	COG0745	RESPONSE REGULATOR receiver
HRD54_RS10655	COG1597	lipid kinase activity
HRD54_RS10660	COG1830	Aldolase
HRD54_RS10680	COG1113	amino acid transport
HRD54_RS10695	COG0561	phosphatase activity
HRD54_RS10700	COG1114	Component of the transport system for branched-chain amino acids
HRD54_RS10705	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD54_RS10710	COG1115	amino acid carrier protein
HRD54_RS10725	COG3140	Belongs to the UPF0181 family
HRD54_RS10735	COG0494	nUDIX hydrolase
HRD54_RS10740	COG1760	l-serine dehydratase
HRD54_RS10745	COG1971	Probably functions as a manganese efflux pump
HRD54_RS10750	COG2226	methyltransferase
HRD54_RS10760	COG0589	response to stress
HRD54_RS10775	COG1113	amino acid transport
HRD54_RS10785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD54_RS10790	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD54_RS10790	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD54_RS10790	COG0506	proline dehydrogenase activity
HRD54_RS10800	COG1191	sigma factor activity
HRD54_RS10845	COG1677	Flagellar hook-basal body complex protein FliE
HRD54_RS10850	COG1766	The M ring may be actively involved in energy transduction
HRD54_RS10865	COG1157	protein secretion by the type III secretion system
HRD54_RS10870	COG2882	bacterial-type flagellum organization
HRD54_RS10880	COG1580	Controls the rotational direction of flagella during chemotaxis
HRD54_RS10900	COG1338	Plays a role in the flagellum-specific transport system
HRD54_RS10905	COG1987	bacterial-type flagellum assembly
HRD54_RS10920	COG1256	bacterial-type flagellum assembly
HRD54_RS10930	COG1706	bacterial-type flagellum-dependent cell motility
HRD54_RS10935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HRD54_RS10960	COG1558	bacterial-type flagellum-dependent cell motility
HRD54_RS10965	COG1815	bacterial-type flagellum-dependent cell motility
HRD54_RS10985	COG3210	domain, Protein
HRD54_RS10995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD54_RS11010	COG0745	RESPONSE REGULATOR receiver
HRD54_RS11015	COG2201	protein-glutamate methylesterase activity
HRD54_RS11025	COG0840	transmembrane signaling receptor activity
HRD54_RS11030	COG0840	transmembrane signaling receptor activity
HRD54_RS11035	COG0835	chemotaxis
HRD54_RS11040	COG2198	Histidine kinase
HRD54_RS11040	COG0643	Histidine kinase
HRD54_RS11045	COG1360	Flagellar Motor Protein
HRD54_RS11065	COG1285	pathogenesis
HRD54_RS11105	COG0418	dihydroorotase activity
HRD54_RS11145	COG1560	Kdo2-lipid A biosynthetic process
HRD54_RS11150	COG2814	Major facilitator Superfamily
HRD54_RS11155	COG3104	oligopeptide transport
HRD54_RS11165	COG1607	acyl-coa hydrolase
HRD54_RS11180	COG1902	pentaerythritol trinitrate reductase activity
HRD54_RS11205	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRD54_RS11210	COG1396	sequence-specific DNA binding
HRD54_RS11220	COG3247	response to pH
HRD54_RS11225	COG0668	transmembrane transport
HRD54_RS11230	COG0243	molybdopterin cofactor binding
HRD54_RS11235	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS11240	COG3302	dmso reductase anchor subunit
HRD54_RS11370	COG0642	Histidine kinase
HRD54_RS11370	COG2198	Histidine kinase
HRD54_RS11375	COG2197	response regulator
HRD54_RS11380	COG0784	Response regulator, receiver
HRD54_RS11380	COG2205	protein histidine kinase activity
HRD54_RS11390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD54_RS11395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD54_RS11400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD54_RS11405	COG0633	Ferredoxin
HRD54_RS11415	COG0814	amino acid
HRD54_RS11435	COG1441	menaquinone biosynthetic process
HRD54_RS11440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRD54_RS11445	COG0596	Alpha beta hydrolase
HRD54_RS11450	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRD54_RS11455	COG1169	isochorismate synthase
HRD54_RS11470	COG1007	ATP synthesis coupled electron transport
HRD54_RS11475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD54_RS11480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD54_RS11485	COG0713	ATP synthesis coupled electron transport
HRD54_RS11490	COG0839	Belongs to the complex I subunit 6 family
HRD54_RS11495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD54_RS11500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD54_RS11510	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HRD54_RS11520	COG0649	NAD binding
HRD54_RS11520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD54_RS11525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD54_RS11530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD54_RS11535	COG0583	DNA-binding transcription factor activity
HRD54_RS11540	COG0436	Aminotransferase
HRD54_RS11545	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD54_RS11550	COG0471	metal ion transport
HRD54_RS11550	COG0490	domain, Protein
HRD54_RS11555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD54_RS11560	COG3013	Belongs to the UPF0304 family
HRD54_RS11565	COG3092	negative regulation of chromosome organization
HRD54_RS11570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD54_RS11575	COG0857	belongs to the CobB CobQ family
HRD54_RS11575	COG0280	phosphate acetyltransferase
HRD54_RS11605	COG3037	sugar-specific permease SgaT UlaA
HRD54_RS11615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD54_RS11625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD54_RS11630	COG0625	glutathione transferase activity
HRD54_RS11635	COG1090	epimerase
HRD54_RS11640	COG0163	prenyltransferase activity
HRD54_RS11645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRD54_RS11650	COG1286	toxin biosynthetic process
HRD54_RS11655	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HRD54_RS11660	COG0285	dihydrofolate synthase activity
HRD54_RS11665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRD54_RS11670	COG0586	Pfam SNARE associated Golgi protein
HRD54_RS11680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD54_RS11685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD54_RS11690	COG2207	Transcriptional regulator
HRD54_RS11695	COG0697	spore germination
HRD54_RS11700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD54_RS11705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRD54_RS11705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD54_RS11725	COG3101	peptidyl-lysine hydroxylation
HRD54_RS11730	COG0730	response to heat
HRD54_RS11735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRD54_RS11745	COG0783	Belongs to the Dps family
HRD54_RS11750	COG2840	Smr protein MutS2
HRD54_RS11755	COG2062	phosphohistidine phosphatase, SixA
HRD54_RS11760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD54_RS11760	COG1024	Enoyl-CoA hydratase
HRD54_RS11765	COG0183	Belongs to the thiolase family
HRD54_RS11770	COG3691	Protein conserved in bacteria
HRD54_RS11775	COG2067	long-chain fatty acid transport protein
HRD54_RS11955	COG0305	Participates in initiation and elongation during chromosome replication
HRD54_RS12040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD54_RS12045	COG3723	Recombinational DNA repair protein, rece pathway
HRD54_RS12050	COG0629	single-stranded DNA binding
HRD54_RS12125	COG1396	sequence-specific DNA binding
HRD54_RS12170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD54_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS12195	COG3530	Putative quorum-sensing-regulated virulence factor
HRD54_RS12200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD54_RS12205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD54_RS12210	COG3115	cell septum assembly
HRD54_RS12220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD54_RS12225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD54_RS12235	COG2190	(PTS) system
HRD54_RS12240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD54_RS12245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRD54_RS12250	COG4208	sulfate ABC transporter
HRD54_RS12255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRD54_RS12265	COG2837	iron assimilation
HRD54_RS12275	COG0456	acetyltransferase
HRD54_RS12280	COG0408	coproporphyrinogen oxidase activity
HRD54_RS12290	COG1160	GTP binding
HRD54_RS12295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD54_RS12300	COG2976	Protein conserved in bacteria
HRD54_RS12305	COG0124	histidyl-tRNA synthetase
HRD54_RS12310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRD54_RS12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRD54_RS12330	COG0105	UTP biosynthetic process
HRD54_RS12335	COG4953	penicillin-binding protein 1C
HRD54_RS12340	COG2373	Large extracellular alpha-helical protein
HRD54_RS12350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD54_RS12355	COG2975	iron-sulfur cluster assembly
HRD54_RS12360	COG0633	Ferredoxin
HRD54_RS12365	COG0443	Heat shock 70 kDa protein
HRD54_RS12370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD54_RS12375	COG0316	Belongs to the HesB IscA family
HRD54_RS12380	COG0822	iron-sulfur transferase activity
HRD54_RS12385	COG1104	cysteine desulfurase activity
HRD54_RS12390	COG1959	2 iron, 2 sulfur cluster binding
HRD54_RS12395	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRD54_RS12400	COG0483	inositol monophosphate 1-phosphatase activity
HRD54_RS12415	COG2814	Major facilitator Superfamily
HRD54_RS12420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRD54_RS12425	COG1017	nitric oxide dioxygenase activity
HRD54_RS12425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD54_RS12435	COG0347	Belongs to the P(II) protein family
HRD54_RS12440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD54_RS12440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD54_RS12445	COG2204	response regulator
HRD54_RS12450	COG3170	Tfp pilus assembly protein FimV
HRD54_RS12455	COG2205	protein histidine kinase activity
HRD54_RS12460	COG0047	phosphoribosylformylglycinamidine synthase activity
HRD54_RS12460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRD54_RS12465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRD54_RS12470	COG3539	Fimbrial protein
HRD54_RS12475	COG3188	usher protein
HRD54_RS12480	COG3121	Chaperone
HRD54_RS12485	COG3539	Fimbrial protein
HRD54_RS12490	COG3539	Fimbrial protein
HRD54_RS12500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD54_RS12505	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD54_RS12510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRD54_RS12515	COG1381	Involved in DNA repair and RecF pathway recombination
HRD54_RS12520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRD54_RS12525	COG0571	ribonuclease III activity
HRD54_RS12530	COG0681	Belongs to the peptidase S26 family
HRD54_RS12535	COG0481	GTPase activity
HRD54_RS12540	COG3086	response to oxidative stress
HRD54_RS12545	COG3026	antisigma factor binding
HRD54_RS12550	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HRD54_RS12555	COG1595	DNA-templated transcription, initiation
HRD54_RS12560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRD54_RS12565	COG0513	Belongs to the DEAD box helicase family
HRD54_RS12570	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HRD54_RS12575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD54_RS12580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD54_RS12585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRD54_RS12590	COG0497	DNA recombination
HRD54_RS12600	COG2914	Belongs to the UPF0125 (RnfH) family
HRD54_RS12605	COG2867	negative regulation of translational initiation
HRD54_RS12610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRD54_RS12645	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRD54_RS12650	COG0732	type I restriction modification DNA specificity domain
HRD54_RS12655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HRD54_RS12705	COG0579	oxidoreductase
HRD54_RS12720	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD54_RS12725	COG1620	l-lactate permease
HRD54_RS12730	COG0247	lactate metabolic process
HRD54_RS12735	COG1139	Iron-sulfur cluster binding protein
HRD54_RS12740	COG1556	Lactate utilization protein
HRD54_RS12755	COG0727	PFAM Uncharacterised protein family (UPF0153)
HRD54_RS12760	COG3738	Protein conserved in bacteria
HRD54_RS12770	COG2819	hydrolase of the alpha beta superfamily
HRD54_RS12775	COG4771	TonB-dependent receptor
HRD54_RS12785	COG1609	Transcriptional regulator
HRD54_RS12790	COG2017	converts alpha-aldose to the beta-anomer
HRD54_RS12795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRD54_RS12800	COG1085	galactose-1-phosphate uridylyltransferase
HRD54_RS12805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRD54_RS12815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRD54_RS12820	COG0589	response to stress
HRD54_RS12825	COG4574	serine-type endopeptidase inhibitor activity
HRD54_RS12830	COG2841	Protein conserved in bacteria
HRD54_RS12905	COG3188	usher protein
HRD54_RS12910	COG3121	Chaperone
HRD54_RS12915	COG3539	Fimbrial protein
HRD54_RS12955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRD54_RS12965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRD54_RS12970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD54_RS12980	COG0716	FMN binding
HRD54_RS12990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HRD54_RS12995	COG0354	folic acid binding
HRD54_RS13005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD54_RS13005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD54_RS13010	COG0509	glycine decarboxylation via glycine cleavage system
HRD54_RS13015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD54_RS13020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD54_RS13025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD54_RS13030	COG0006	proline dipeptidase activity
HRD54_RS13035	COG3079	Belongs to the UPF0149 family
HRD54_RS13040	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HRD54_RS13050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRD54_RS13060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD54_RS13070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD54_RS13075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRD54_RS13080	COG0583	DNA-binding transcription factor activity
HRD54_RS13100	COG1279	arginine transmembrane transporter activity
HRD54_RS13110	COG3112	Uncharacterised protein family (UPF0231)
HRD54_RS13130	COG3064	Membrane
HRD54_RS13130	COG1073	alpha beta
HRD54_RS13130	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRD54_RS13135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD54_RS13140	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD54_RS13145	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD54_RS13150	COG2186	Transcriptional regulator
HRD54_RS13155	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD54_RS13160	COG4969	Belongs to the N-Me-Phe pilin family
HRD54_RS13165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD54_RS13175	COG0237	dephospho-CoA kinase activity
HRD54_RS13180	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HRD54_RS13185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRD54_RS13210	COG0789	Transcriptional regulator
HRD54_RS13215	COG0653	protein targeting
HRD54_RS13230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HRD54_RS13240	COG0849	cell division
HRD54_RS13245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRD54_RS13255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD54_RS13260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD54_RS13265	COG0772	Belongs to the SEDS family
HRD54_RS13275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD54_RS13280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRD54_RS13285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRD54_RS13290	COG0768	penicillin binding
HRD54_RS13300	COG0275	rRNA processing
HRD54_RS13305	COG2001	Belongs to the MraZ family
HRD54_RS13315	COG1022	Amp-dependent synthetase and ligase
HRD54_RS13325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD54_RS13330	COG0473	3-isopropylmalate dehydrogenase activity
HRD54_RS13335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD54_RS13340	COG0066	3-isopropylmalate dehydratase activity
HRD54_RS13345	COG4533	DNA binding
HRD54_RS13350	COG3066	DNA modification
HRD54_RS13360	COG3657	addiction module killer protein
HRD54_RS13370	COG0010	Belongs to the arginase family
HRD54_RS13375	COG1166	arginine decarboxylase activity
HRD54_RS13380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRD54_RS13395	COG1192	Involved in chromosome partitioning
HRD54_RS13410	COG3118	belongs to the thioredoxin family
HRD54_RS13410	COG0457	Tetratricopeptide repeat
HRD54_RS13425	COG0640	Transcriptional regulator
HRD54_RS13430	COG3091	SprT-like family
HRD54_RS13435	COG2239	Acts as a magnesium transporter
HRD54_RS13445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD54_RS13450	COG1151	hydroxylamine reductase activity
HRD54_RS13460	COG1115	amino acid carrier protein
HRD54_RS13475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD54_RS13480	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HRD54_RS13485	COG2353	YceI-like domain
HRD54_RS13490	COG3038	cytochrome b561
HRD54_RS13500	COG5295	Hep Hag repeat protein
HRD54_RS13510	COG3119	arylsulfatase activity
HRD54_RS13540	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS13550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD54_RS13555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD54_RS13555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS13560	COG3716	PTS system mannose fructose sorbose family IID component
HRD54_RS13565	COG3715	PTS system
HRD54_RS13570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS13575	COG2222	sugar isomerase
HRD54_RS13585	COG1349	DNA-binding transcription factor activity
HRD54_RS13590	COG0641	radical SAM
HRD54_RS13595	COG3119	arylsulfatase activity
HRD54_RS13610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD54_RS13615	COG0800	Aldolase
HRD54_RS13630	COG0384	phenazine biosynthesis protein PhzF
HRD54_RS13635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD54_RS13640	COG0640	Transcriptional regulator
HRD54_RS13650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HRD54_RS13670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD54_RS13675	COG2501	S4 domain
HRD54_RS13680	COG1105	Belongs to the carbohydrate kinase PfkB family
HRD54_RS13685	COG0215	cysteine-tRNA ligase activity
HRD54_RS13690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD54_RS13695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD54_RS13700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRD54_RS13705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRD54_RS13715	COG0668	transmembrane transport
HRD54_RS13720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRD54_RS13725	COG4181	ATPase activity
HRD54_RS13730	COG2755	lipolytic protein G-D-S-L family
HRD54_RS13735	COG0300	oxidoreductase activity
HRD54_RS13740	COG3118	belongs to the thioredoxin family
HRD54_RS13745	COG0330	HflC and HflK could
HRD54_RS13755	COG0789	Transcriptional regulator
HRD54_RS13770	COG3735	TraB family
HRD54_RS13780	COG0737	Belongs to the 5'-nucleotidase family
HRD54_RS13785	COG4651	solute:proton antiporter activity
HRD54_RS13785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD54_RS13790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD54_RS13795	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD54_RS13800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRD54_RS13805	COG0563	adenylate kinase activity
HRD54_RS13810	COG0326	Molecular chaperone. Has ATPase activity
HRD54_RS13815	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRD54_RS13820	COG2962	Rard protein
HRD54_RS13840	COG4566	intracellular signal transduction
HRD54_RS13855	COG4589	Belongs to the CDS family
HRD54_RS13865	COG0583	DNA-binding transcription factor activity
HRD54_RS13875	COG0549	Belongs to the carbamate kinase family
HRD54_RS13885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD54_RS13890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD54_RS13895	COG1335	isochorismatase
HRD54_RS13910	COG0471	metal ion transport
HRD54_RS13935	COG3539	Fimbrial protein
HRD54_RS14005	COG0613	PHP domain protein
HRD54_RS14010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS14010	COG1263	PTS System
HRD54_RS14010	COG2190	(PTS) system
HRD54_RS14015	COG3711	transcriptional antiterminator
HRD54_RS14095	COG0786	glutamate:sodium symporter activity
HRD54_RS14110	COG0640	Transcriptional regulator
HRD54_RS14235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRD54_RS14420	COG3423	Transcriptional regulator
HRD54_RS14445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRD54_RS14455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HRD54_RS14465	COG0582	viral genome integration into host DNA
HRD54_RS14470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRD54_RS14480	COG1388	LysM domain
HRD54_RS14480	COG4942	peptidase
HRD54_RS14485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRD54_RS14490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRD54_RS14495	COG0585	pseudouridine synthase activity
HRD54_RS14500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRD54_RS14505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRD54_RS14520	COG2895	sulfate adenylyltransferase (ATP) activity
HRD54_RS14525	COG0175	sulfate reduction
HRD54_RS14530	COG1648	precorrin-2 dehydrogenase activity
HRD54_RS14530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD54_RS14535	COG0175	sulfate reduction
HRD54_RS14540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD54_RS14545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRD54_RS14550	COG0720	synthase
HRD54_RS14555	COG0602	queuosine metabolic process
HRD54_RS14610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD54_RS14615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD54_RS14620	COG2011	ABC-type metal ion transport system permease component
HRD54_RS14625	COG1464	Belongs to the NlpA lipoprotein family
HRD54_RS14635	COG1720	tRNA m6t6A37 methyltransferase activity
HRD54_RS14640	COG0442	prolyl-tRNA aminoacylation
HRD54_RS14645	COG3015	lipoprotein NlpE involved in copper resistance
HRD54_RS14650	COG4568	rho-dependent transcription termination
HRD54_RS14655	COG0037	tRNA processing
HRD54_RS14665	COG0825	malonyl-CoA metabolic process
HRD54_RS14675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRD54_RS14680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD54_RS14685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD54_RS14690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD54_RS14695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD54_RS14705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD54_RS14715	COG0575	Belongs to the CDS family
HRD54_RS14720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRD54_RS14725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD54_RS14730	COG0233	cytoplasmic translational termination
HRD54_RS14735	COG0528	UMP kinase activity
HRD54_RS14740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRD54_RS14745	COG0052	Belongs to the universal ribosomal protein uS2 family
HRD54_RS14755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRD54_RS14760	COG2171	N-acyltransferase activity
HRD54_RS14770	COG0716	FMN binding
HRD54_RS14780	COG1263	PTS System
HRD54_RS14780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS14790	COG3098	single-species biofilm formation
HRD54_RS14800	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD54_RS14800	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD54_RS14805	COG1611	Belongs to the LOG family
HRD54_RS14810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD54_RS14815	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HRD54_RS14820	COG2363	Small membrane protein
HRD54_RS14825	COG0583	DNA-binding transcription factor activity
HRD54_RS14830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD54_RS14835	COG2166	iron-sulfur cluster assembly
HRD54_RS14840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRD54_RS14845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRD54_RS14865	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD54_RS14870	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRD54_RS14870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD54_RS14875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRD54_RS14880	COG1074	ATP-dependent DNA helicase activity
HRD54_RS14885	COG1025	Belongs to the peptidase M16 family
HRD54_RS14890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HRD54_RS14920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRD54_RS14930	COG0494	nUDIX hydrolase
HRD54_RS14935	COG4143	(ABC) transporter
HRD54_RS14940	COG1178	ABC-type Fe3 transport system permease component
HRD54_RS14945	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HRD54_RS14950	COG0417	DNA replication proofreading
HRD54_RS14955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRD54_RS14960	COG0564	pseudouridine synthase activity
HRD54_RS14965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD54_RS14970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD54_RS14975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD54_RS14980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRD54_RS14985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRD54_RS14990	COG2967	ApaG domain
HRD54_RS14995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD54_RS15015	COG2132	Multicopper oxidase
HRD54_RS15020	COG0204	Acyl-transferase
HRD54_RS15025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRD54_RS15030	COG0187	DNA topoisomerase II activity
HRD54_RS15035	COG3150	esterase
HRD54_RS15040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRD54_RS15045	COG0494	nUDIX hydrolase
HRD54_RS15050	COG1538	Outer membrane efflux protein
HRD54_RS15055	COG5463	Belongs to the UPF0441 family
HRD54_RS15060	COG0754	glutathionylspermidine amidase activity
HRD54_RS15065	COG3384	dioxygenase
HRD54_RS15070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD54_RS15080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRD54_RS15080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRD54_RS15085	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRD54_RS15090	COG3025	triphosphatase activity
HRD54_RS15095	COG4991	sh3 domain protein
HRD54_RS15100	COG0617	tRNA 3'-terminal CCA addition
HRD54_RS15105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRD54_RS15110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRD54_RS15130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRD54_RS15135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD54_RS15140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRD54_RS15145	COG0358	DNA primase activity
HRD54_RS15165	COG3781	membrane
HRD54_RS15175	COG1294	oxidase, subunit
HRD54_RS15180	COG1271	oxidase subunit
HRD54_RS15185	COG0243	molybdopterin cofactor binding
HRD54_RS15190	COG0583	DNA-binding transcription factor activity
HRD54_RS15195	COG0840	transmembrane signaling receptor activity
HRD54_RS15200	COG0840	transmembrane signaling receptor activity
HRD54_RS15250	COG1358	cellular component organization or biogenesis
HRD54_RS15315	COG2376	Dihydroxyacetone kinase
HRD54_RS15320	COG1461	Dihydroxyacetone kinase
HRD54_RS15325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD54_RS15325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HRD54_RS15325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD54_RS15335	COG4191	Histidine kinase
HRD54_RS15345	COG2271	Major facilitator Superfamily
HRD54_RS15350	COG0469	pyruvate kinase activity
HRD54_RS15355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HRD54_RS15365	COG2851	Citrate transporter
HRD54_RS15370	COG0813	purine-nucleoside phosphorylase activity
HRD54_RS15375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD54_RS15380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRD54_RS15385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRD54_RS15390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD54_RS15395	COG0084	hydrolase, TatD family'
HRD54_RS15400	COG4667	esterase of the alpha-beta hydrolase superfamily
HRD54_RS15410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRD54_RS15435	COG2813	Specifically methylates the guanine in position
HRD54_RS15450	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRD54_RS15460	COG0675	Transposase, IS605 OrfB family
HRD54_RS15470	COG2382	esterase
HRD54_RS15490	COG0560	Phosphoserine phosphatase
HRD54_RS15495	COG3726	membrane protein affecting hemolysin expression
HRD54_RS15500	COG1328	CTP reductase activity
HRD54_RS15505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD54_RS15525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD54_RS15540	COG1216	Glycosyl transferase, family 2
HRD54_RS15545	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD54_RS15555	COG3260	NADH ubiquinone oxidoreductase 20
HRD54_RS15560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD54_RS15565	COG3261	NADH dehydrogenase
HRD54_RS15565	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HRD54_RS15570	COG0651	ATP synthesis coupled electron transport
HRD54_RS15575	COG4237	Hydrogenase 4 membrane
HRD54_RS15580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD54_RS15585	COG0650	Formate hydrogenlyase subunit 4
HRD54_RS15590	COG0651	ATP synthesis coupled electron transport
HRD54_RS15595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD54_RS15600	COG0698	ribose 5-phosphate isomerase
HRD54_RS15605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD54_RS15620	COG3188	usher protein
HRD54_RS15655	COG0702	epimerase
HRD54_RS15665	COG0675	Transposase, IS605 OrfB family
HRD54_RS15675	COG0459	protein refolding
HRD54_RS15680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD54_RS15695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD54_RS15700	COG1309	transcriptional regulator
HRD54_RS15715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HRD54_RS15720	COG1704	LemA family
HRD54_RS15735	COG2255	four-way junction helicase activity
HRD54_RS15740	COG2271	Major facilitator Superfamily
HRD54_RS15745	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HRD54_RS15750	COG0644	oxidoreductase
HRD54_RS15770	COG1960	acyl-CoA dehydrogenase activity
HRD54_RS15775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRD54_RS15780	COG0318	PFAM AMP-dependent synthetase and ligase
HRD54_RS15785	COG1024	Enoyl-CoA hydratase
HRD54_RS15805	COG3397	chitin binding
HRD54_RS15810	COG2137	regulation of response to DNA damage stimulus
HRD54_RS15830	COG2992	FlgJ-related protein
HRD54_RS15855	COG2610	gluconate transmembrane transporter activity
HRD54_RS15860	COG3265	gluconokinase activity
HRD54_RS15865	COG1609	Transcriptional regulator
HRD54_RS15880	COG1120	ATPase activity
HRD54_RS15885	COG0500	methyltransferase
HRD54_RS15890	COG0157	Belongs to the NadC ModD family
HRD54_RS15935	COG4790	Type iii secretion
HRD54_RS15980	COG2207	Transcriptional regulator
HRD54_RS16020	COG0789	Transcriptional regulator
HRD54_RS16035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD54_RS16085	COG4869	propanediol catabolic process
HRD54_RS16095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD54_RS16100	COG1882	Formate acetyltransferase
HRD54_RS16110	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HRD54_RS16115	COG1012	belongs to the aldehyde dehydrogenase family
HRD54_RS16115	COG1454	alcohol dehydrogenase
HRD54_RS16150	COG2873	o-acetylhomoserine
HRD54_RS16170	COG3188	usher protein
HRD54_RS16175	COG3539	Fimbrial protein
HRD54_RS16195	COG1177	transmembrane transport
HRD54_RS16220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD54_RS16240	COG1448	Aminotransferase
HRD54_RS16250	COG0814	amino acid
HRD54_RS16255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD54_RS16265	COG0735	belongs to the Fur family
HRD54_RS16270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD54_RS16275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRD54_RS16280	COG2937	Belongs to the GPAT DAPAT family
HRD54_RS16285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRD54_RS16290	COG3161	chorismate lyase activity
HRD54_RS16295	COG0166	Belongs to the GPI family
HRD54_RS16300	COG0527	aspartate kinase activity
HRD54_RS16315	COG0646	methionine synthase
HRD54_RS16315	COG1410	methionine synthase
HRD54_RS16325	COG0129	dihydroxy-acid dehydratase activity
HRD54_RS16330	COG0800	Aldolase
HRD54_RS16340	COG2224	Isocitrate lyase
HRD54_RS16345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRD54_RS16350	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRD54_RS16360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD54_RS16390	COG0138	bifunctional purine biosynthesis protein purh
HRD54_RS16395	COG0151	Belongs to the GarS family
HRD54_RS16410	COG3068	Protein conserved in bacteria
HRD54_RS16415	COG1515	deoxyribonuclease V activity
HRD54_RS16420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRD54_RS16425	COG2816	NAD+ diphosphatase activity
HRD54_RS16435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRD54_RS16440	COG0352	thiamine-phosphate diphosphorylase activity
HRD54_RS16445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD54_RS16450	COG2104	thiamine diphosphate biosynthetic process
HRD54_RS16455	COG2022	thiamine diphosphate biosynthetic process
HRD54_RS16465	COG5464	transposase or invertase
HRD54_RS16470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRD54_RS16475	COG0085	RNA polymerase activity
HRD54_RS16480	COG0222	ribosome binding
HRD54_RS16485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRD54_RS16490	COG0081	regulation of translation
HRD54_RS16495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRD54_RS16500	COG0250	Participates in transcription elongation, termination and antitermination
HRD54_RS16515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRD54_RS16520	COG0049	tRNA binding
HRD54_RS16525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRD54_RS16535	COG2923	Belongs to the DsrF TusC family
HRD54_RS16540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD54_RS16545	COG2964	Protein conserved in bacteria
HRD54_RS16555	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD54_RS16560	COG2900	Belongs to the SlyX family
HRD54_RS16565	COG1047	Peptidyl-prolyl cis-trans
HRD54_RS16570	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HRD54_RS16580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD54_RS16585	COG0488	(ABC) transporter
HRD54_RS16590	COG0840	transmembrane signaling receptor activity
HRD54_RS16595	COG0840	transmembrane signaling receptor activity
HRD54_RS16600	COG0840	transmembrane signaling receptor activity
HRD54_RS16615	COG0429	hydrolase of the alpha beta-hydrolase fold
HRD54_RS16625	COG3954	Phosphoribulokinase
HRD54_RS16630	COG1765	OsmC-like protein
HRD54_RS16635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD54_RS16640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD54_RS16650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD54_RS16660	COG0242	peptide deformylase activity
HRD54_RS16665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD54_RS16665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD54_RS16675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD54_RS16680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRD54_RS16685	COG3084	Protein conserved in bacteria
HRD54_RS16690	COG0746	molybdenum cofactor guanylyltransferase activity
HRD54_RS16695	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRD54_RS16710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD54_RS16715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRD54_RS16725	COG1295	ribonuclease BN
HRD54_RS16730	COG1942	4-Oxalocrotonate Tautomerase
HRD54_RS16740	COG2199	diguanylate cyclase activity
HRD54_RS16740	COG2200	EAL domain
HRD54_RS16745	COG3210	domain, Protein
HRD54_RS16750	COG4608	Belongs to the ABC transporter superfamily
HRD54_RS16755	COG0444	Belongs to the ABC transporter superfamily
HRD54_RS16760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD54_RS16765	COG0601	transmembrane transport
HRD54_RS16770	COG0747	negative chemotaxis
HRD54_RS16790	COG5645	(Lipo)protein
HRD54_RS16795	COG0569	domain protein
HRD54_RS16795	COG2985	domain, Protein
HRD54_RS16800	COG3977	Valine--pyruvate aminotransferase
HRD54_RS16805	COG2818	Glycosylase
HRD54_RS16810	COG0752	glycyl-tRNA synthetase alpha subunit
HRD54_RS16815	COG0751	glycine-tRNA ligase activity
HRD54_RS16830	COG0823	Involved in the tonB-independent uptake of proteins
HRD54_RS16835	COG2860	membrane
HRD54_RS16840	COG0194	GDP metabolic process
HRD54_RS16845	COG1758	RNA polymerase activity
HRD54_RS16850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD54_RS16855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD54_RS16860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRD54_RS16865	COG0786	glutamate:sodium symporter activity
HRD54_RS16870	COG2233	PERMEase
HRD54_RS16875	COG2982	Protein involved in outer membrane biogenesis
HRD54_RS16885	COG1187	pseudouridine synthase activity
HRD54_RS16890	COG0456	acetyltransferase
HRD54_RS16895	COG1490	D-aminoacyl-tRNA deacylase activity
HRD54_RS16900	COG1011	Hydrolase
HRD54_RS16945	COG3157	Type VI secretion system effector, Hcp
HRD54_RS17005	COG2183	response to ionizing radiation
HRD54_RS17010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD54_RS17015	COG0745	RESPONSE REGULATOR receiver
HRD54_RS17020	COG2205	protein histidine kinase activity
HRD54_RS17025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD54_RS17030	COG0573	inorganic phosphate transmembrane transporter activity
HRD54_RS17035	COG0581	inorganic phosphate transmembrane transporter activity
HRD54_RS17045	COG0704	Plays a role in the regulation of phosphate uptake
HRD54_RS17050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD54_RS17060	COG0765	amino acid transport
HRD54_RS17085	COG1136	(ABC) transporter
HRD54_RS17100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD54_RS17105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD54_RS17110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRD54_RS17115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD54_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS17125	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD54_RS17135	COG2252	PERMEase
HRD54_RS17140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD54_RS17160	COG1918	ferrous iron import across plasma membrane
HRD54_RS17165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRD54_RS17180	COG2267	carboxylic ester hydrolase activity
HRD54_RS17185	COG1040	competence protein
HRD54_RS17190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRD54_RS17190	COG0316	Belongs to the HesB IscA family
HRD54_RS17195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD54_RS17200	COG0705	Rhomboid family
HRD54_RS17205	COG1349	DNA-binding transcription factor activity
HRD54_RS17210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD54_RS17215	COG3189	MarR family transcriptional regulator
HRD54_RS17255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD54_RS17265	COG1069	ribulokinase activity
HRD54_RS17275	COG1124	(ABC) transporter
HRD54_RS17290	COG0601	transmembrane transport
HRD54_RS17295	COG0747	negative chemotaxis
HRD54_RS17300	COG2226	methyltransferase
HRD54_RS17315	COG3394	polysaccharide catabolic process
HRD54_RS17320	COG1486	melibiose metabolic process
HRD54_RS17325	COG1917	Cupin 2, conserved barrel domain protein
HRD54_RS17325	COG2169	Transcriptional regulator
HRD54_RS17330	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD54_RS17335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD54_RS17340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD54_RS17345	COG4607	ABC-type enterochelin transport system periplasmic component
HRD54_RS17350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD54_RS17355	COG4605	iron ion homeostasis
HRD54_RS17360	COG4604	ABC transporter, ATP-binding protein
HRD54_RS17380	COG0243	molybdopterin cofactor binding
HRD54_RS17385	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS17390	COG3302	dmso reductase anchor subunit
HRD54_RS17395	COG1609	Transcriptional regulator
HRD54_RS17405	COG2211	Major facilitator Superfamily
HRD54_RS17410	COG1285	pathogenesis
HRD54_RS17415	COG2755	lipolytic protein G-D-S-L family
HRD54_RS17415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRD54_RS17430	COG1737	Transcriptional regulator
HRD54_RS17435	COG2731	YhcH YjgK YiaL family protein
HRD54_RS17440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD54_RS17450	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HRD54_RS17455	COG3383	formate dehydrogenase (NAD+) activity
HRD54_RS17460	COG0733	neurotransmitter:sodium symporter activity
HRD54_RS17465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD54_RS17470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD54_RS17470	COG1263	PTS System
HRD54_RS17475	COG1737	Transcriptional regulator
HRD54_RS17480	COG1278	Cold shock
HRD54_RS17490	COG3122	Protein conserved in bacteria
HRD54_RS17505	COG3501	Rhs element vgr protein
HRD54_RS17555	COG3188	usher protein
HRD54_RS17590	COG0742	ribosomal rna small subunit methyltransferase
HRD54_RS17595	COG1028	Short-chain dehydrogenase reductase Sdr
HRD54_RS17605	COG0589	response to stress
HRD54_RS17615	COG0306	phosphate transporter
HRD54_RS17620	COG2081	HI0933 family
HRD54_RS17625	COG1741	Belongs to the pirin family
HRD54_RS17630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRD54_RS17635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HRD54_RS17640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HRD54_RS17650	COG0494	nUDIX hydrolase
HRD54_RS17660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD54_RS17680	COG4796	Type ii and iii secretion system protein
HRD54_RS17685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD54_RS17690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRD54_RS17705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD54_RS17710	COG0546	phosphoglycolate phosphatase activity
HRD54_RS17715	COG0180	Tryptophanyl-tRNA synthetase
HRD54_RS17720	COG2258	MOSC domain
HRD54_RS17725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRD54_RS17730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD54_RS17735	COG3162	membrane
HRD54_RS17740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD54_RS17745	COG2194	sulfuric ester hydrolase activity
HRD54_RS17750	COG1556	Lactate utilization protein
HRD54_RS17755	COG1139	Iron-sulfur cluster binding protein
HRD54_RS17760	COG0247	lactate metabolic process
HRD54_RS17785	COG2186	Transcriptional regulator
HRD54_RS17790	COG0477	Major facilitator Superfamily
HRD54_RS17795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD54_RS17800	COG0714	Associated with various cellular activities
HRD54_RS17805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRD54_RS17810	COG2502	aspartate--ammonia ligase
HRD54_RS17815	COG1522	sequence-specific DNA binding
HRD54_RS17820	COG0716	FMN binding
HRD54_RS17825	COG0445	tRNA wobble uridine modification
HRD54_RS17830	COG0357	Ribosomal RNA small subunit methyltransferase G
HRD54_RS17835	COG3312	ion transport
HRD54_RS17840	COG0356	it plays a direct role in the translocation of protons across the membrane
HRD54_RS17850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRD54_RS17855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD54_RS17860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRD54_RS17865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRD54_RS17870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRD54_RS17875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRD54_RS17880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRD54_RS17885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRD54_RS17890	COG3842	ATPase activity
HRD54_RS17895	COG1178	ABC-type Fe3 transport system permease component
HRD54_RS17900	COG1840	ABC-type Fe3 transport system, periplasmic component
HRD54_RS17905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD54_RS17920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD54_RS17930	COG1288	antiporter activity
HRD54_RS17965	COG3188	usher protein
HRD54_RS17990	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD54_RS18000	COG1940	carbohydrate kinase activity
HRD54_RS18010	COG1215	transferase activity, transferring glycosyl groups
HRD54_RS18020	COG0457	Tetratricopeptide repeat
HRD54_RS18030	COG3706	GGDEF domain
HRD54_RS18035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD54_RS18040	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HRD54_RS18045	COG1368	sulfuric ester hydrolase activity
HRD54_RS18050	COG3276	selenocysteine insertion sequence binding
HRD54_RS18055	COG1921	L-seryl-tRNASec selenium transferase activity
HRD54_RS18060	COG3058	Necessary for formate dehydrogenase activity
HRD54_RS18065	COG2864	formate dehydrogenase
HRD54_RS18070	COG0437	4 iron, 4 sulfur cluster binding
HRD54_RS18080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRD54_RS18095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD54_RS18100	COG0583	DNA-binding transcription factor activity
HRD54_RS18140	COG3550	peptidyl-serine autophosphorylation
HRD54_RS18200	COG0464	growth
HRD54_RS18215	COG1074	ATP-dependent DNA helicase activity
HRD54_RS18285	COG4974	Belongs to the 'phage' integrase family
HRD54_RS18290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRD54_RS18295	COG0706	membrane insertase activity
HRD54_RS18300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRD54_RS18305	COG0594	ribonuclease P activity
HRD54_RS18310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRD54_RS18460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD54_RS18465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD54_RS18475	COG0629	single-stranded DNA binding
HRD54_RS18490	COG3157	Type VI secretion system effector, Hcp
HRD54_RS18510	COG1192	Involved in chromosome partitioning
HRD54_RS18515	COG2336	PFAM SpoVT AbrB
HRD54_RS18520	COG2337	Toxic component of a toxin-antitoxin (TA) module
HRD54_RS18590	COG3173	Aminoglycoside phosphotransferase
HRD54_RS18625	COG0673	inositol 2-dehydrogenase activity
HRD54_RS18630	COG1324	tolerance protein
HRD54_RS18850	COG0681	Belongs to the peptidase S26 family