locus-tag class description HNS37_RS00025 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HNS37_RS00030 ENOG4105V0I UPF0267 protein HNS37_RS00035 ENOG4105C5H ABC transporter HNS37_RS00040 ENOG4105CPF Cell wall formation (By similarity) HNS37_RS00045 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HNS37_RS00060 ENOG4105D01 (LipO)protein HNS37_RS00065 ENOG4105C28 cystathionine HNS37_RS00070 ENOG4108Z9I -acetyltransferase HNS37_RS00080 ENOG4105E5W Transporter HNS37_RS00085 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HNS37_RS00090 ENOG4105CBN LysR family transcriptional regulator HNS37_RS00110 ENOG4105C5H ABC transporter HNS37_RS00115 ENOG4108UPT UPF0178 protein HNS37_RS00120 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HNS37_RS00130 ENOG4105CNH Multidrug resistance protein MdtL HNS37_RS00145 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HNS37_RS00155 ENOG4105J12 Multidrug resistance protein mdtN HNS37_RS00160 ENOG4108MI0 Resistance protein HNS37_RS00165 ENOG4105DFG type I secretion outer membrane protein HNS37_RS00185 ENOG4105CC0 LysR family Transcriptional regulator HNS37_RS00190 ENOG4105R8A Heat shock protein HNS37_RS00195 ENOG4105C5W Aldolase HNS37_RS00205 ENOG4108NIW Leucine export protein LeuE HNS37_RS00210 ENOG4105CMG Carbohydrate kinase HNS37_RS00215 ENOG4105C93 Xylose Isomerase HNS37_RS00230 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HNS37_RS00270 ENOG4105EMU Dehydrogenase HNS37_RS00275 ENOG4105M5Q UPF0482 protein HNS37_RS00285 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HNS37_RS00290 ENOG4105DAG ROK family HNS37_RS00295 ENOG4106NZI LysR family Transcriptional regulator HNS37_RS00300 ENOG4105D94 Major Facilitator Superfamily HNS37_RS00305 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HNS37_RS00310 ENOG4105C9Q fumarate hydratase class II HNS37_RS00315 ENOG4106J39 exported protein HNS37_RS00325 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HNS37_RS00330 ENOG4105DHU Bile acid HNS37_RS00335 ENOG4105D9R oxidoreductase HNS37_RS00340 ENOG4105M9B inner membrane protein ydgK HNS37_RS00345 ENOG4105DGN Electron transport complex HNS37_RS00355 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HNS37_RS00365 ENOG4108UQQ Electron transport complex HNS37_RS00375 ENOG4105CSM endonuclease III HNS37_RS00380 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HNS37_RS00385 ENOG4108ZJT translation initiation factor, Sui1 HNS37_RS00390 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HNS37_RS00395 ENOG4105CFV Tetratricopeptide repeat protein HNS37_RS00400 ENOG4105Q4A inner membrane protein yciS HNS37_RS00405 ENOG4105EYK Phosphatidylglycerophosphatase B HNS37_RS00410 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HNS37_RS00415 ENOG4105D01 (LipO)protein HNS37_RS00420 ENOG4107QM5 aconitate hydratase HNS37_RS00430 ENOG4107R11 Transcriptional regulator HNS37_RS00455 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HNS37_RS00460 ENOG4105RKX Protein of unknown function (DUF2498) HNS37_RS00465 ENOG4105ERU peptidase HNS37_RS00470 ENOG4105UBK short-chain dehydrogenase reductase HNS37_RS00475 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HNS37_RS00485 ENOG4105FE9 pseudouridine synthase HNS37_RS00490 ENOG4107RTD sua5 ycio yrdc ywlc family protein HNS37_RS00495 ENOG4105DB7 PHP domain protein HNS37_RS00500 ENOG4105CRQ synthase (Component I) HNS37_RS00505 ENOG4105DDQ anthranilate synthase HNS37_RS00510 ENOG4107QYG anthranilate phosphoribosyltransferase HNS37_RS00515 ENOG4105DK0 Indole-3-glycerol phosphate synthase HNS37_RS00520 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HNS37_RS00525 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HNS37_RS00535 ENOG4105EIF outer membrane protein W HNS37_RS00540 ENOG4108S3I UPF0259 membrane protein HNS37_RS00550 ENOG4107835 probably involved in intracellular septation (By similarity) HNS37_RS00555 ENOG4105NAU thioesterase Superfamily protein HNS37_RS00570 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HNS37_RS00580 ENOG4108T1M outer membrane protein x HNS37_RS00585 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HNS37_RS00605 ENOG4107RX3 Mg2 transporter protein cora family protein HNS37_RS00615 ENOG4105H38 Membrane HNS37_RS00620 ENOG4107QSI ABC, transporter HNS37_RS00625 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HNS37_RS00640 ENOG4106K28 UPF0283 membrane protein HNS37_RS00645 ENOG4105CM6 amino acid regulated cytosolic protein HNS37_RS00655 ENOG4105FM1 phage shock protein C HNS37_RS00660 ENOG4105YYT phage shock protein B HNS37_RS00665 ENOG41087YS Phage shock protein A HNS37_RS00670 ENOG4105E51 psp operon transcriptional activator HNS37_RS00675 ENOG4108HIY periplasmic HNS37_RS00680 ENOG4108EKA peptide transport system, permease HNS37_RS00685 ENOG4108EU3 peptide transport system, permease HNS37_RS00690 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HNS37_RS00695 ENOG4108JQ2 peptide transport system atp-binding protein HNS37_RS00700 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HNS37_RS00705 ENOG4108K3A Glutathione S-transferase HNS37_RS00710 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HNS37_RS00715 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HNS37_RS00720 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HNS37_RS00725 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HNS37_RS00730 ENOG4108XTF Outer Membrane Lipoprotein HNS37_RS00740 ENOG4105XZD Fe-S protein HNS37_RS00745 ENOG4108UYE Lactoylglutathione lyase HNS37_RS00750 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HNS37_RS00755 ENOG4105M2J Glutaredoxin HNS37_RS00760 ENOG4105NAE bifunctional deaminase-reductase domain protein HNS37_RS00775 ENOG4105HF0 Membrane HNS37_RS00780 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HNS37_RS00790 ENOG4105ETE Transcriptional regulator (LacI family HNS37_RS00795 ENOG4105F52 Transcriptional regulator HNS37_RS00800 ENOG4105CZQ inner membrane transport protein YdhC HNS37_RS00805 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HNS37_RS00810 ENOG4108R6K riboflavin synthase, subunit alpha HNS37_RS00815 ENOG4107QI1 Mate efflux family protein HNS37_RS00830 ENOG4105CA9 Pyruvate kinase HNS37_RS00835 ENOG4105E5D amino acid HNS37_RS00840 ENOG4105CVK Glutamate decarboxylase HNS37_RS00850 ENOG4105KMX major outer membrane lipoprotein HNS37_RS00860 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HNS37_RS00865 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HNS37_RS00870 ENOG4105C9B Cysteine desulfurase HNS37_RS00875 ENOG4105JRK feS assembly protein SufD HNS37_RS00880 ENOG4105C3K feS assembly ATPase SufC HNS37_RS00885 ENOG4105DIW FeS assembly protein SUFB HNS37_RS00890 ENOG4108Z4V iron-sulfur cluster assembly HNS37_RS00900 ENOG4105KA0 thioesterase Superfamily protein HNS37_RS00905 ENOG4105CQB FAD linked oxidase domain protein HNS37_RS00910 ENOG4105IPI Membrane HNS37_RS00915 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HNS37_RS00920 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HNS37_RS00925 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HNS37_RS00930 ENOG4107F3C Hemin uptake protein HNS37_RS00935 ENOG4107ENK receptor HNS37_RS00940 ENOG4107ENK receptor HNS37_RS00945 ENOG4106QJH hemin transport protein HNS37_RS00950 ENOG4107R4I Periplasmic binding protein HNS37_RS00955 ENOG4105EHG Permease protein HNS37_RS00960 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS00965 ENOG4105EW9 transcriptional regulator AsnC family HNS37_RS00970 ENOG4105N14 lysine exporter protein LysE YggA HNS37_RS00975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HNS37_RS00980 ENOG4105C4M (Ubiquinol oxidase) subunit I HNS37_RS00985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HNS37_RS01000 ENOG4105KAF membrAne HNS37_RS01005 ENOG4105D5M phosphate starvation-inducible protein HNS37_RS01015 ENOG4105RWS endonuclease I HNS37_RS01025 ENOG4107XM3 UPF0442 protein HNS37_RS01030 ENOG4105DWK Membrane HNS37_RS01040 ENOG4108U51 Universal stress protein HNS37_RS01050 ENOG4108U51 Universal stress protein HNS37_RS01055 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HNS37_RS01060 ENOG4105XVG cytoplasmic protein HNS37_RS01070 ENOG4105D52 delta-aminolevulinic acid dehydratase HNS37_RS01080 ENOG4105DZC cytosine deaminase HNS37_RS01085 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HNS37_RS01090 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HNS37_RS01095 ENOG4105C26 Dehydrogenase HNS37_RS01100 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HNS37_RS01105 ENOG4105C94 Transporter HNS37_RS01110 ENOG4105CIH Imidazole acetol-phosphate transaminase HNS37_RS01120 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HNS37_RS01125 ENOG4105CW0 outer membrane usher protein HNS37_RS01130 ENOG4108AF8 Chaperone HNS37_RS01135 ENOG4108S54 Fimbrial protein HNS37_RS01140 ENOG4108WDE Fimbrial protein HNS37_RS01145 ENOG4105ZUU Transcriptional regulator HNS37_RS01150 ENOG4108JQ7 (ABC) transporter HNS37_RS01155 ENOG4105C3U ABC transporter HNS37_RS01160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNS37_RS01165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HNS37_RS01170 ENOG4107QSI ABC, transporter HNS37_RS01175 ENOG4107QSI ABC, transporter HNS37_RS01185 ENOG4105WZK nitrite reductase NADPH small subunit HNS37_RS01190 ENOG4107QZF nitrite reductase NADPH large subunit HNS37_RS01200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HNS37_RS01205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNS37_RS01215 ENOG4108JQ7 (ABC) transporter HNS37_RS01220 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HNS37_RS01225 ENOG4105C0A alcohol dehydrogenase HNS37_RS01230 ENOG4107104 thymidine kinase HNS37_RS01245 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HNS37_RS01250 ENOG4105I93 response regulator HNS37_RS01255 ENOG4105K5B UPF0225 protein HNS37_RS01260 ENOG4105CIY formyltetrahydrofolate deformylase HNS37_RS01270 ENOG4105ETT transcriptional Regulator, LysR family HNS37_RS01275 ENOG4105CGK Exodeoxyribonuclease III HNS37_RS01280 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HNS37_RS01285 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HNS37_RS01290 ENOG41069NU Nitroreductase HNS37_RS01295 ENOG4105D07 Signal peptide peptidase, SppA HNS37_RS01300 ENOG4105HDK L-asparaginase HNS37_RS01305 ENOG4108RWI nicotinamidase HNS37_RS01315 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HNS37_RS01320 ENOG4105VUT cytoplasmic protein HNS37_RS01325 ENOG4105E0X reductase HNS37_RS01335 ENOG4105DSB aldose 1-epimerase HNS37_RS01340 ENOG4105GNX MltA-interacting MipA family protein HNS37_RS01345 ENOG4105C8H hydrogenase maturation protein Hypf HNS37_RS01350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HNS37_RS01355 ENOG4105MWK D-amino acid dehydrogenase, small subunit HNS37_RS01360 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HNS37_RS01365 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HNS37_RS01370 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HNS37_RS01380 ENOG410814C multidrug resistance protein HNS37_RS01385 ENOG4105F27 Major Facilitator HNS37_RS01430 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HNS37_RS01435 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HNS37_RS01440 ENOG4105WH1 Two component transcriptional regulator luxr family HNS37_RS01445 ENOG4108TVJ Nitroreductase HNS37_RS01450 ENOG4105CBT Fructose-1,6-bisphosphatase HNS37_RS01455 ENOG41080QX K07048 phosphotriesterase-related protein HNS37_RS01490 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HNS37_RS01515 ENOG4108VEN abc transporter atp-binding protein HNS37_RS01525 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein HNS37_RS01530 ENOG4105DKT Transcriptional regulator HNS37_RS01535 ENOG4105VF7 tolerance protein HNS37_RS01555 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HNS37_RS01560 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HNS37_RS01565 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HNS37_RS01575 ENOG4105CUG Oligopeptidase b HNS37_RS01590 ENOG4105C6K Malic enzyme HNS37_RS01595 ENOG4105WH1 Two component transcriptional regulator luxr family HNS37_RS01605 ENOG4105KUZ arsenate reductase HNS37_RS01610 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HNS37_RS01620 ENOG4105WD1 Membrane HNS37_RS01625 ENOG4105XYK UPF0370 protein HNS37_RS01630 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HNS37_RS01635 ENOG4108VMM UPF0756 membrane protein HNS37_RS01640 ENOG4105CGZ zinc metallopeptidase HNS37_RS01645 ENOG4105C8V SAICAR synthetase HNS37_RS01650 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HNS37_RS01655 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HNS37_RS01660 ENOG4105RH4 Glycine cleavage system transcriptional repressor HNS37_RS01665 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HNS37_RS01670 ENOG4105C02 permease HNS37_RS01675 ENOG4105ERG peptidase m48, ste24p HNS37_RS01680 ENOG4105K89 arsenate reductase HNS37_RS01685 ENOG4105EAA nucleoside HNS37_RS01690 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HNS37_RS01695 ENOG4105CUY Mechanosensitive ion channel HNS37_RS01700 ENOG4105C2W permease HNS37_RS01705 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HNS37_RS01710 ENOG4105CXB phosphoribosylaminoimidazole synthetase HNS37_RS01715 ENOG4108V3E phosphoribosylglycinamide formyltransferase HNS37_RS01720 ENOG4108MK9 spermidine N(1)-acetyltransferase HNS37_RS01725 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HNS37_RS01730 ENOG4105C9X ppx gppa phosphatase HNS37_RS01735 ENOG4105CJW magnesium transporter HNS37_RS01745 ENOG4105CSH Transporter HNS37_RS01750 ENOG4105DUX Transporter HNS37_RS01755 ENOG4105ENT Efflux transporter rnd family, mfp subunit HNS37_RS01760 ENOG4105BZS acriflavin resistance protein HNS37_RS01765 ENOG4105BZS acriflavin resistance protein HNS37_RS01770 ENOG4105EB3 Histidine kinase HNS37_RS01775 ENOG4105E3W Two component transcriptional regulator (Winged helix family HNS37_RS01780 ENOG4105CFP Peptidase U32 HNS37_RS01785 ENOG4107TE5 Lipid kinase HNS37_RS01790 ENOG4105EIE fructose-bisphosphate aldolase HNS37_RS01795 ENOG4105DWF phosphomethylpyrimidine kinase HNS37_RS01805 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HNS37_RS01810 ENOG4105C85 amino acid HNS37_RS01820 ENOG4108W3Q Transcriptional regulator HNS37_RS01825 ENOG410667J hydrolase HNS37_RS01830 ENOG4105CWM branched-chain amino acid transport system II carrier protein HNS37_RS01835 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HNS37_RS01840 ENOG4105BZG amino acid carrier protein HNS37_RS01845 ENOG4105MPK DNA polymerase III subunit theta HNS37_RS01855 ENOG4105X5C UPF0181 protein HNS37_RS01860 ENOG4105CRQ synthase (Component I) HNS37_RS01865 ENOG4105P8F nudix hydrolase HNS37_RS01870 ENOG4105EJQ L-serine dehydratase HNS37_RS01875 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HNS37_RS01880 ENOG4105DHI Methyltransferase HNS37_RS01885 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HNS37_RS01890 ENOG41081QV Universal stress protein HNS37_RS01900 ENOG4108U51 Universal stress protein HNS37_RS01905 ENOG4105C85 amino acid HNS37_RS01915 ENOG4105CK7 Sodium proline symporter HNS37_RS01920 ENOG4105C26 Dehydrogenase HNS37_RS01925 ENOG4108M9K flagella biosynthesis protein FliZ HNS37_RS01930 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNS37_RS01945 ENOG4105DTS flagellar hook-associated HNS37_RS01950 ENOG4105MQ3 flagellar protein FliS HNS37_RS01955 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HNS37_RS01980 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HNS37_RS01985 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HNS37_RS01990 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HNS37_RS01995 ENOG41090PJ Flagellar assembly protein HNS37_RS02000 ENOG4108JIR Flagellum-specific ATP synthase HNS37_RS02005 ENOG4105GSA Flagellar export protein flij HNS37_RS02010 ENOG4105WF4 Flagellar hook-length control protein HNS37_RS02015 ENOG4107ZI8 flagellar basal body-associated protein flil HNS37_RS02020 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HNS37_RS02025 ENOG4105DD5 Flagellar motor switch protein HNS37_RS02030 ENOG4105K0P flagellar biosynthesis protein HNS37_RS02035 ENOG4105CN7 Flagellar biosynthetic protein FliP HNS37_RS02045 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HNS37_RS02050 ENOG4105DTJ flagellar hook-associated protein HNS37_RS02055 ENOG4105E1Q flagellar hook-associated protein HNS37_RS02060 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HNS37_RS02065 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HNS37_RS02070 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HNS37_RS02075 ENOG4105CGA flagellar basal-body rod protein FlgG HNS37_RS02080 ENOG4108KPB Flagellar basal-body rod protein FlgF HNS37_RS02085 ENOG4105BZE flagellar hook protein, FlgE HNS37_RS02090 ENOG4105W00 Flagellar hook capping protein HNS37_RS02095 ENOG4108ZC9 flagellar basal-body rod protein flgc HNS37_RS02100 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HNS37_RS02105 ENOG4105CKS Flagella basal body P-ring formation protein flgA HNS37_RS02110 ENOG4105M9M anti-sigma28 factor FlgM HNS37_RS02115 ENOG4105QVD Flagella synthesis protein FlgN HNS37_RS02125 ENOG4105D7B Flagellar biosynthesis protein flha HNS37_RS02130 ENOG4105D00 flagellar biosynthetic protein flhB HNS37_RS02135 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HNS37_RS02140 ENOG4108VYJ response regulator receiver protein HNS37_RS02145 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HNS37_RS02150 ENOG4105BZU Histidine kinase HNS37_RS02155 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS02160 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS02165 ENOG4108V3W Chemotaxis protein, CheW HNS37_RS02170 ENOG4105CBS Chea signal transduction histidine kinase HNS37_RS02175 ENOG4105ER2 Ompa motb domain protein HNS37_RS02180 ENOG4107RD7 Flagellar Motor Protein, MotA HNS37_RS02185 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HNS37_RS02190 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HNS37_RS02195 ENOG4105KT7 mgtC SapB transporter HNS37_RS02210 ENOG4105GSJ Inner membrane protein ylaC HNS37_RS02235 ENOG4105EKE dihydroorotase HNS37_RS02240 ENOG4105PVA Biofilm formation regulatory protein BssS HNS37_RS02250 ENOG4105DB1 molybdopterin oxidoreductase HNS37_RS02255 ENOG4106WHD Tetrathionate reductase HNS37_RS02260 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HNS37_RS02265 ENOG4106AFQ Histidine kinase HNS37_RS02270 ENOG4108ZXC Two component transcriptional regulator, luxr family HNS37_RS02275 ENOG4105D1S lipid A biosynthesis HNS37_RS02280 ENOG4105C6X Major Facilitator HNS37_RS02285 ENOG4105DUX Transporter HNS37_RS02290 ENOG4105JAB phenazine biosynthesis protein, phzf family HNS37_RS02310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HNS37_RS02335 ENOG4108UMN azlc family HNS37_RS02340 ENOG4105WBV Transcriptional regulator HNS37_RS02345 ENOG4105F0I Aminotransferase HNS37_RS02350 ENOG4108YK4 Acid-resistance membrane protein HNS37_RS02355 ENOG4105CUY Mechanosensitive ion channel HNS37_RS02360 ENOG4107QY8 reductase HNS37_RS02365 ENOG4105QAX Iron-sulfur HNS37_RS02370 ENOG4107KGK dmso reductase anchor subunit HNS37_RS02500 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HNS37_RS02505 ENOG41068CG regulatoR HNS37_RS02510 ENOG4105BZU Histidine kinase HNS37_RS02515 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNS37_RS02520 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HNS37_RS02525 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HNS37_RS02530 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HNS37_RS02535 ENOG4105XPH Ferredoxin HNS37_RS02540 ENOG4105M5B (LipO)protein HNS37_RS02545 ENOG4105E0U tyrosine-specific transport protein HNS37_RS02550 ENOG4108UII YfaZ family HNS37_RS02555 ENOG4105CH6 catalase HNS37_RS02570 ENOG4105CEY Amp-dependent synthetase and ligase HNS37_RS02575 ENOG4105DNI Converts SHCHC to OSB (By similarity) HNS37_RS02580 ENOG4108IPT Naphthoate synthase HNS37_RS02585 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HNS37_RS02590 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HNS37_RS02595 ENOG4105E4F Isochorismate synthase HNS37_RS02610 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HNS37_RS02615 ENOG4105C8S subunit m HNS37_RS02620 ENOG4105D65 subunit l HNS37_RS02625 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HNS37_RS02630 ENOG4107UFS subunit j HNS37_RS02635 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HNS37_RS02640 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HNS37_RS02645 ENOG4108IEH NADH dehydrogenase subunit g HNS37_RS02650 ENOG4107QIZ NADH dehydrogenase HNS37_RS02655 ENOG4105GKE subunit e HNS37_RS02660 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HNS37_RS02665 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HNS37_RS02670 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HNS37_RS02675 ENOG4107NQ8 LysR family Transcriptional regulator HNS37_RS02680 ENOG4105CHM Aminotransferase HNS37_RS02685 ENOG4105DK2 UPF0207 protein HNS37_RS02690 ENOG4107QWE )-transporter HNS37_RS02695 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HNS37_RS02700 ENOG4105XWI UPF0304 protein HNS37_RS02705 ENOG4105PQ6 UPF0208 membrane protein HNS37_RS02710 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HNS37_RS02715 ENOG4105C6K Malic enzyme HNS37_RS02725 ENOG4105DZG Dehydrogenase HNS37_RS02730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HNS37_RS02735 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HNS37_RS02745 ENOG4106ETB IIa component HNS37_RS02755 ENOG4105PTV Nudix Hydrolase HNS37_RS02760 ENOG4105CYM Glutathione S-transferase HNS37_RS02765 ENOG4105ECP epimerase HNS37_RS02770 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HNS37_RS02775 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HNS37_RS02780 ENOG4105E96 Colicin v production protein HNS37_RS02785 ENOG4108S3P Sporulation domain protein HNS37_RS02790 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HNS37_RS02795 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HNS37_RS02800 ENOG4105DQR SNARE associated Golgi HNS37_RS02805 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HNS37_RS02810 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HNS37_RS02815 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HNS37_RS02820 ENOG4105Z68 AraC Family Transcriptional Regulator HNS37_RS02825 ENOG410631K Membrane HNS37_RS02830 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HNS37_RS02835 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HNS37_RS02840 ENOG4105XYF acetyltransferase HNS37_RS02850 ENOG4105MH2 YfcL protein HNS37_RS02855 ENOG4108BPE -transporting atpase HNS37_RS02860 ENOG4105EJ9 Membrane HNS37_RS02865 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HNS37_RS02870 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HNS37_RS02880 ENOG4108DG9 Smr protein MutS2 HNS37_RS02885 ENOG4108BY2 phosphohistidine phosphatase HNS37_RS02890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HNS37_RS02895 ENOG4105CHU acetyl-coa acetyltransferase HNS37_RS02900 ENOG4105KZW UPF0381 protein HNS37_RS02905 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HNS37_RS02910 ENOG410903C (LipO)protein HNS37_RS02935 ENOG4108J2R molybdopterin oxidoreductase HNS37_RS02940 ENOG4105QAX Iron-sulfur HNS37_RS02945 ENOG4108NWD Cytochrome HNS37_RS02950 ENOG4105ZUU Transcriptional regulator HNS37_RS02990 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HNS37_RS03005 ENOG4105CHR reductase HNS37_RS03015 ENOG4105VRT cytoplasmic protein HNS37_RS03020 ENOG4105D9N nucleoside HNS37_RS03025 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HNS37_RS03030 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HNS37_RS03035 ENOG4105EXN Sulfate transport protein CysZ HNS37_RS03040 ENOG4105C6T cysteine synthase HNS37_RS03050 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HNS37_RS03055 ENOG4105C5Y PTS System HNS37_RS03060 ENOG4105C6T cysteine synthase HNS37_RS03065 ENOG4108IJ6 ABC transporter HNS37_RS03070 ENOG4105ECW sulfate abc transporter HNS37_RS03075 ENOG4108I5D sulfate abc transporter HNS37_RS03080 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HNS37_RS03085 ENOG4105EZR dyp-type peroxidase family protein HNS37_RS03090 ENOG4105E7K (LipO)protein HNS37_RS03095 ENOG4108R6G acetyltransferase HNS37_RS03100 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HNS37_RS03110 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HNS37_RS03115 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HNS37_RS03120 ENOG4105N21 Membrane HNS37_RS03125 ENOG4105CUT histidyl-tRNA synthetase HNS37_RS03130 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HNS37_RS03135 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HNS37_RS03145 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HNS37_RS03150 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HNS37_RS03155 ENOG4108JQB penicillin-binding protein 1C HNS37_RS03160 ENOG4105DN3 alpha-2-macroglobulin domain protein HNS37_RS03165 ENOG4105YYA enhanced serine sensitivity protein SseB HNS37_RS03170 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HNS37_RS03175 ENOG4105WVQ Fe-S assembly protein IscX HNS37_RS03180 ENOG4108ZIT Ferredoxin, 2FE-2S HNS37_RS03185 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HNS37_RS03190 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HNS37_RS03195 ENOG4108Z4V iron-sulfur cluster assembly HNS37_RS03200 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HNS37_RS03205 ENOG4105C3J Cysteine desulfurase HNS37_RS03210 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HNS37_RS03215 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HNS37_RS03220 ENOG4105ECY inositol monophosphatase HNS37_RS03235 ENOG4105D8G Major Facilitator superfamily HNS37_RS03240 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HNS37_RS03245 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HNS37_RS03255 ENOG4108YZA Nitrogen regulatory protein pii HNS37_RS03260 ENOG4105C4K Nad synthetase HNS37_RS03265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HNS37_RS03270 ENOG4108SKK alpha helix protein HNS37_RS03275 ENOG4107WP9 Histidine kinase HNS37_RS03280 ENOG4107QIK phosphoribosylformylglycinamidine synthase HNS37_RS03285 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HNS37_RS03290 ENOG4108TH4 Major fimbrial subunit HNS37_RS03295 ENOG4106PG1 outer membrane usher protein HNS37_RS03300 ENOG4108FZ9 Chaperone HNS37_RS03305 ENOG4108MDY Fimbrial HNS37_RS03310 ENOG4108YUF Fimbrial HNS37_RS03315 ENOG4108Z6B deaminase HNS37_RS03320 ENOG4105N14 lysine exporter protein LysE YggA HNS37_RS03325 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HNS37_RS03330 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HNS37_RS03335 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HNS37_RS03340 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HNS37_RS03345 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HNS37_RS03350 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HNS37_RS03355 ENOG4105C3F Signal peptidase i HNS37_RS03360 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HNS37_RS03365 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HNS37_RS03370 ENOG4105VQK sigma E regulatory protein, MucB RseB HNS37_RS03375 ENOG41069PW sigma-e factor negative regulatory protein HNS37_RS03380 ENOG4105EMN RNA polymerase sigma factor HNS37_RS03385 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HNS37_RS03390 ENOG4105C1J atp-dependent rna helicase HNS37_RS03395 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HNS37_RS03400 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HNS37_RS03405 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HNS37_RS03410 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HNS37_RS03415 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HNS37_RS03420 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HNS37_RS03425 ENOG4105VDB UPF0125 protein HNS37_RS03430 ENOG4108Z1B Cyclase dehydrase HNS37_RS03435 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HNS37_RS03460 ENOG4105CNU cell division protein FtsK HNS37_RS03465 ENOG4105DZR Type I site-specific deoxyribonuclease HNS37_RS03470 ENOG4105EKX Restriction modification system DNA (Specificity HNS37_RS03520 ENOG4105DZR Type I site-specific deoxyribonuclease HNS37_RS03575 ENOG4105D5K Hemolysin activator protein HNS37_RS03580 ENOG41067NU HNS37_RS03670 ENOG4105DWT malate dehydrogenase (quinone) HNS37_RS03685 ENOG4105NF4 modulator of drug activity HNS37_RS03690 ENOG4105F27 Major Facilitator HNS37_RS03700 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HNS37_RS03705 ENOG4107QR9 Iron-sulfur cluster binding protein HNS37_RS03710 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HNS37_RS03725 ENOG4105PI0 Ferredoxin HNS37_RS03730 ENOG4108XC3 NADH ubiquinone oxidoreductase HNS37_RS03740 ENOG4105NIV Esterase HNS37_RS03745 ENOG4105D05 Receptor HNS37_RS03755 ENOG41060NJ transcriptional regulator HNS37_RS03760 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HNS37_RS03765 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HNS37_RS03770 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HNS37_RS03775 ENOG4105CMR udp-glucose 4-epimerase HNS37_RS03790 ENOG4108RW8 Universal stress protein F HNS37_RS03795 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) HNS37_RS03800 ENOG4105Z2P Protein of unknown function (DUF465) HNS37_RS03805 ENOG4105VVZ metal-binding protein HNS37_RS03815 ENOG4105VXR cytoplasmic protein HNS37_RS03820 ENOG4108YYQ gCN5-related N-acetyltransferase HNS37_RS03870 ENOG4105CRK lysyL-tRNA synthetase HNS37_RS03880 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HNS37_RS03885 ENOG4105T95 Thiol disulfide interChange protein HNS37_RS03890 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNS37_RS03895 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HNS37_RS03905 ENOG4105Y75 tpr repeat protein HNS37_RS03910 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HNS37_RS03920 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HNS37_RS03925 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HNS37_RS03930 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HNS37_RS03935 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HNS37_RS03940 ENOG4105D0A hydroxylase HNS37_RS03945 ENOG4107RAQ aminopeptidase HNS37_RS03950 ENOG4105E07 UPF0149 protein HNS37_RS03955 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HNS37_RS03965 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HNS37_RS03975 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HNS37_RS03980 ENOG4108JJA ABC, transporter HNS37_RS03990 ENOG4108JQ1 Dehydrogenase HNS37_RS03995 ENOG4105E66 phosphoriboisomerase A HNS37_RS04000 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HNS37_RS04015 ENOG4105MPN Membrane HNS37_RS04020 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HNS37_RS04025 ENOG4105D64 Mechanosensitive ion channel HNS37_RS04030 ENOG4108ZIG UPF0231 protein HNS37_RS04035 ENOG4107QIJ Aconitate hydratase 2 HNS37_RS04040 ENOG4107QN2 dihydrolipoyl dehydrogenase HNS37_RS04045 ENOG4107QSN dihydrolipoamide acetyltransferase HNS37_RS04050 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HNS37_RS04055 ENOG41073TP transcriptional regulator HNS37_RS04060 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HNS37_RS04065 ENOG4108ZUW Major pilin subunit HNS37_RS04070 ENOG4107QHF type ii secretion system protein e HNS37_RS04080 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HNS37_RS04085 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HNS37_RS04090 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HNS37_RS04100 ENOG4108I4D hemolysin HNS37_RS04105 ENOG4106IWJ hemolysin HNS37_RS04110 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HNS37_RS04115 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HNS37_RS04125 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HNS37_RS04130 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HNS37_RS04135 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HNS37_RS04140 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HNS37_RS04150 ENOG4105DFU Cell wall formation (By similarity) HNS37_RS04155 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HNS37_RS04160 ENOG4105CNI cell division protein FtsW HNS37_RS04165 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HNS37_RS04170 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HNS37_RS04175 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HNS37_RS04180 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HNS37_RS04185 ENOG4105CJN penicillin-binding protein HNS37_RS04190 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HNS37_RS04195 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HNS37_RS04200 ENOG4108V6E Cell division protein mraZ HNS37_RS04205 ENOG4107B7Y DNA-binding transcriptional regulator FruR HNS37_RS04210 ENOG4108IQE Amp-dependent synthetase and ligase HNS37_RS04215 ENOG41064T2 transcriptional regulator, lysR family HNS37_RS04220 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HNS37_RS04225 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HNS37_RS04230 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HNS37_RS04235 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HNS37_RS04240 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HNS37_RS04245 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HNS37_RS04255 ENOG4105VUH addiction module killer protein HNS37_RS04260 ENOG4105CHR reductase HNS37_RS04265 ENOG4105CYW agmatinase HNS37_RS04270 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HNS37_RS04275 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HNS37_RS04280 ENOG4105D1V cellulose synthase operon protein YhjU HNS37_RS04295 ENOG4107QZ7 Cellulose synthase catalytic subunit HNS37_RS04300 ENOG4107EEX Cellulose synthase regulator protein HNS37_RS04305 ENOG4105EJG cellulose synthase HNS37_RS04320 ENOG41080HT Transcriptional regulator, arsr family HNS37_RS04325 ENOG4105GPY SprT protein HNS37_RS04340 ENOG4105CJW magnesium transporter HNS37_RS04350 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HNS37_RS04355 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HNS37_RS04365 ENOG4105BZG amino acid carrier protein HNS37_RS04380 ENOG4107SVH Potassium channel protein HNS37_RS04385 ENOG4107QHE Choloylglycine hydrolase HNS37_RS04390 ENOG4108YYC ycei family HNS37_RS04395 ENOG4105DS1 cytochrome b561 HNS37_RS04415 ENOG4105CBG Sulfatase HNS37_RS04445 ENOG4105CHR reductase HNS37_RS04455 ENOG4105CE4 GlcNAc 6-P deacetylase HNS37_RS04460 ENOG4105DAS pts system HNS37_RS04465 ENOG4105F3R pts system mannose fructose sorbose family iid HNS37_RS04470 ENOG4105ETZ PTS System HNS37_RS04475 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HNS37_RS04480 ENOG4105E70 isomerase HNS37_RS04485 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HNS37_RS04490 ENOG4105E98 transcriptional regulator DeoR family HNS37_RS04495 ENOG4105C4X radical SAM domain protein HNS37_RS04500 ENOG4105ENH Sulfatase HNS37_RS04510 ENOG4105D2N Aldolase HNS37_RS04515 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HNS37_RS04520 ENOG4108UHU Aldolase HNS37_RS04530 ENOG4105MWK D-amino acid dehydrogenase, small subunit HNS37_RS04535 ENOG4107ZY0 Phenazine biosynthesis-like protein HNS37_RS04545 ENOG4105KBH arsR family transcriptional regulator HNS37_RS04555 ENOG4105RHY Pfam:UPF0157 HNS37_RS04575 ENOG4107YB6 acetyltransferase, (GNAT) family HNS37_RS04580 ENOG4105MPK DNA polymerase III subunit theta HNS37_RS04585 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HNS37_RS04590 ENOG4105CKK Glycosyl transferase, family 2 HNS37_RS04775 ENOG4105HGD Antitermination protein HNS37_RS04815 ENOG4105DH7 May be involved in recombination (By similarity) HNS37_RS04885 ENOG4105UMD exodeoxyribonuclease X HNS37_RS04895 ENOG4108UUM single-stranded DNA-binding protein HNS37_RS04935 ENOG4108KU3 Integrase HNS37_RS04945 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HNS37_RS04950 ENOG4105WQ3 Rna-binding protein HNS37_RS04955 ENOG4105DE4 1-phosphofructokinase HNS37_RS04960 ENOG4105C8N cysteinyl-tRNA synthetase HNS37_RS04965 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HNS37_RS04970 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HNS37_RS04975 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HNS37_RS04980 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HNS37_RS04990 ENOG4105D64 Mechanosensitive ion channel HNS37_RS05000 ENOG4108I0Y (ABC) transporter HNS37_RS05005 ENOG4108UJV acyl-CoA thioesterase i HNS37_RS05010 ENOG4105E1F short-chain dehydrogenase reductase HNS37_RS05015 ENOG4107QR8 Thioredoxin HNS37_RS05020 ENOG4107QX8 SPFH domain, Band 7 family protein HNS37_RS05030 ENOG4108Z6Z Transcriptional regulator HNS37_RS05035 ENOG4105C59 p-type ATPase HNS37_RS05045 ENOG4105MBR gumn family HNS37_RS05050 ENOG4108Z66 YbaK ebsC protein HNS37_RS05055 ENOG4105CGH 5'-nucleotidase HNS37_RS05060 ENOG4105CKD glutathione-regulated potassium-efflux system protein HNS37_RS05065 ENOG4107RE1 Inosine-guanosine kinase HNS37_RS05070 ENOG4108QY5 Ferric enterobactin transport protein HNS37_RS05075 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HNS37_RS05080 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HNS37_RS05085 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HNS37_RS05090 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HNS37_RS05095 ENOG4105FR1 rard protein HNS37_RS05100 ENOG4105D7K pfkb domain protein HNS37_RS05105 ENOG4108HKT sucrose-6-phosphate hydrolase HNS37_RS05110 ENOG4106NDP Transcriptional regulator HNS37_RS05115 ENOG4108ZXC Two component transcriptional regulator, luxr family HNS37_RS05130 ENOG4108HPI phosphatidate Cytidylyltransferase HNS37_RS05140 ENOG4107653 Transcriptional regulator HNS37_RS05150 ENOG4105C5B carbamate kinase HNS37_RS05155 ENOG4105G5A Protein of unknown function (DUF2877) HNS37_RS05160 ENOG4107REC cytoplasmic protein HNS37_RS05165 ENOG4107R1Q Membrane protein FdrA HNS37_RS05170 ENOG4105CHJ isochorismatase hydrolase HNS37_RS05175 ENOG4105EUB pirin domain protein HNS37_RS05185 ENOG4107QPK )-transporter HNS37_RS05210 ENOG4108T65 Fimbrial HNS37_RS05215 ENOG4105CW0 outer membrane usher protein HNS37_RS05225 ENOG4106EAR Fimbrial protein HNS37_RS05245 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR HNS37_RS05255 ENOG4106P2F Pfam:Pili_assembly_C HNS37_RS05260 ENOG4106PG1 outer membrane usher protein HNS37_RS05270 ENOG4105HMV Fimbrial protein HNS37_RS05280 ENOG4105DB7 PHP domain protein HNS37_RS05285 ENOG4105C5Y PTS System HNS37_RS05290 ENOG4105CID antiterminator HNS37_RS05295 ENOG4105K5X acetyltransferase HNS37_RS05300 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HNS37_RS05310 ENOG4108K5P (LipO)protein HNS37_RS05315 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HNS37_RS05320 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HNS37_RS05325 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HNS37_RS05330 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HNS37_RS05335 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HNS37_RS05340 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HNS37_RS05345 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HNS37_RS05350 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HNS37_RS05355 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HNS37_RS05360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HNS37_RS05365 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HNS37_RS05370 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HNS37_RS05375 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HNS37_RS05380 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HNS37_RS05385 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HNS37_RS05390 ENOG4105C85 amino acid HNS37_RS05440 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HNS37_RS05445 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS05450 ENOG4108UMI ABC transporter, permease HNS37_RS05455 ENOG4105D01 (LipO)protein HNS37_RS05465 ENOG4108R96 Methyltransferase, YaeB family HNS37_RS05470 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HNS37_RS05475 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HNS37_RS05480 ENOG4105M1T rho-binding antiterminator HNS37_RS05485 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HNS37_RS05490 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HNS37_RS05495 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HNS37_RS05500 ENOG4105C0B DNA polymerase III (alpha subunit) HNS37_RS05505 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HNS37_RS05510 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HNS37_RS05515 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HNS37_RS05520 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HNS37_RS05525 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HNS37_RS05530 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HNS37_RS05535 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HNS37_RS05545 ENOG4105KNE Phosphatidate cytidylyltransferase HNS37_RS05550 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HNS37_RS05555 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HNS37_RS05560 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HNS37_RS05565 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HNS37_RS05570 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HNS37_RS05575 ENOG4105CE9 30S ribosomal protein S2 HNS37_RS05580 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HNS37_RS05585 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HNS37_RS05590 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HNS37_RS05595 ENOG4108T8E UPF0325 protein HNS37_RS05600 ENOG4105QDK Flavodoxin HNS37_RS05610 ENOG4105CI1 PTS System HNS37_RS05615 ENOG4105DR9 pseudouridine synthase HNS37_RS05620 ENOG4105WP7 tRNA pseudouridine synthase C HNS37_RS05625 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HNS37_RS05630 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HNS37_RS05635 ENOG4105EWT decarboxylase family HNS37_RS05640 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HNS37_RS05645 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HNS37_RS05650 ENOG4105M08 Membrane HNS37_RS05655 ENOG4105ETT transcriptional Regulator, LysR family HNS37_RS05660 ENOG4105C9B Cysteine desulfurase HNS37_RS05665 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HNS37_RS05670 ENOG4105CUZ uba thif-type nad fad binding protein HNS37_RS05675 ENOG4105CA3 membrane-bound lytic murein transglycosylase HNS37_RS05695 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HNS37_RS05700 ENOG4107QZM n-acetylglutamate synthase HNS37_RS05705 ENOG4107QYX exodeoxyribonuclease v alpha HNS37_RS05710 ENOG4107QKA exodeoxyribonuclease V beta HNS37_RS05715 ENOG4107QXK peptidase HNS37_RS05720 ENOG4105DSY exodeoxyribonuclease V, gamma HNS37_RS05745 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HNS37_RS05750 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HNS37_RS05755 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HNS37_RS05760 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HNS37_RS05765 ENOG4105DP9 ABC transporter HNS37_RS05770 ENOG4106SMU thiamine transporter membrane protein HNS37_RS05775 ENOG4107T0D ABC, transporter HNS37_RS05780 ENOG4105VT3 DNA binding domain protein, excisionase family HNS37_RS05790 ENOG4105CQ2 DNA polymerase HNS37_RS05795 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HNS37_RS05800 ENOG4105D3G Pseudouridine synthase HNS37_RS05805 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HNS37_RS05810 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HNS37_RS05815 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HNS37_RS05820 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HNS37_RS05825 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HNS37_RS05830 ENOG4105NWN ApaG protein HNS37_RS05835 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HNS37_RS05840 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HNS37_RS05855 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HNS37_RS05860 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HNS37_RS05865 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNS37_RS05870 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNS37_RS05875 ENOG4105IPS esterase HNS37_RS05880 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HNS37_RS05885 ENOG41087AY ADP-Ribose pyrophosphatase HNS37_RS05890 ENOG4105DFG type I secretion outer membrane protein HNS37_RS05895 ENOG4105F1G UPF0441 protein HNS37_RS05900 ENOG4106032 Glutathionylspermidine synthase HNS37_RS05905 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HNS37_RS05910 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HNS37_RS05915 ENOG4105W0Z cytoplasmic protein HNS37_RS05920 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HNS37_RS05925 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HNS37_RS05930 ENOG4105I7R Adenylate cyclase HNS37_RS05935 ENOG4106MWK domain protein HNS37_RS05940 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HNS37_RS05945 ENOG4107ZVW dihydroneopterin aldolase HNS37_RS05950 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HNS37_RS05970 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HNS37_RS05975 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HNS37_RS05985 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HNS37_RS05990 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNS37_RS06005 ENOG4105GMB type VI secretion system effector, hcp1 family HNS37_RS06030 ENOG4105FFC UPF0187 protein HNS37_RS06040 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HNS37_RS06045 ENOG4105C4M (Ubiquinol oxidase) subunit I HNS37_RS06050 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HNS37_RS06055 ENOG4105DUM transcriptional regulator, lysR family HNS37_RS06060 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS06065 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS06115 ENOG4105DAX Pfam:DUF2983 HNS37_RS06170 ENOG4105CMT Dihydroxyacetone kinase HNS37_RS06175 ENOG4108UTZ Dihydroxyacetone kinase HNS37_RS06180 ENOG4105VDH Dihydroxyacetone kinase HNS37_RS06200 ENOG4105UGQ Fimbrial HNS37_RS06205 ENOG4108FZ9 Chaperone HNS37_RS06210 ENOG4106PG1 outer membrane usher protein HNS37_RS06220 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HNS37_RS06235 ENOG4105CXY transporter HNS37_RS06240 ENOG4105CA9 Pyruvate kinase HNS37_RS06245 ENOG4105KSC Transcriptional regulator, TraR DksA family HNS37_RS06255 ENOG4105D4T Citrate transporter HNS37_RS06260 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HNS37_RS06265 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HNS37_RS06270 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HNS37_RS06275 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HNS37_RS06280 ENOG4105D9N nucleoside HNS37_RS06285 ENOG4105EYA deoxyribonuclease HNS37_RS06290 ENOG4108NRW Phospholipase, patatin family HNS37_RS06300 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HNS37_RS06315 ENOG4108RS6 transposase HNS37_RS06320 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HNS37_RS06330 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HNS37_RS06345 ENOG4105EAM Na Pi-cotransporter HNS37_RS06350 ENOG4105G6Z alkaline phosphatase HNS37_RS06355 ENOG4105D7V transposase HNS37_RS06360 ENOG4108RS6 transposase HNS37_RS06365 ENOG4105E93 esterase HNS37_RS06375 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HNS37_RS06380 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HNS37_RS06385 ENOG4105EAC phosphoserine phosphatase HNS37_RS06390 ENOG41062Z9 Membrane HNS37_RS06395 ENOG4105G0K glycine radical enzyme YjjI family HNS37_RS06400 ENOG41076CZ activating enzyme HNS37_RS06410 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS06420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNS37_RS06435 ENOG4105K64 Glycosyl transferase, family 2 HNS37_RS06450 ENOG4108MG9 hydrogenase 3 maturation protease HNS37_RS06455 ENOG4105I6X formate hydrogenlyase maturation HNS37_RS06460 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HNS37_RS06470 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HNS37_RS06475 ENOG4108JPZ Monovalent cation H antiporter subunit D HNS37_RS06480 ENOG4107WQX hydrogenase 4 membrane subunit HNS37_RS06485 ENOG4105D65 subunit l HNS37_RS06490 ENOG4107TDF Formate hydrogenlyase subunit 4 HNS37_RS06495 ENOG4108JPZ Monovalent cation H antiporter subunit D HNS37_RS06500 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HNS37_RS06505 ENOG4108YZG isomerase HNS37_RS06510 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HNS37_RS06515 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HNS37_RS06525 ENOG4105CW0 outer membrane usher protein HNS37_RS06530 ENOG4108VCD Chaperone HNS37_RS06565 ENOG4108ZVF (LipO)protein HNS37_RS06575 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HNS37_RS06580 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HNS37_RS06595 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HNS37_RS06600 ENOG4108SIC Transcriptional regulator HNS37_RS06615 ENOG4105HA9 of methanol dehydrogenase type HNS37_RS06620 ENOG4108V0P LemA family HNS37_RS06635 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HNS37_RS06640 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HNS37_RS06645 ENOG4105WQV ferredoxin-like protein HNS37_RS06650 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HNS37_RS06655 ENOG4105C10 Electron transfer flavoprotein HNS37_RS06660 ENOG4105CV7 Electron transfer flavoprotein HNS37_RS06665 ENOG4105C1G acyl-Coa dehydrogenase HNS37_RS06670 ENOG4105CY2 Citrate transporter HNS37_RS06675 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HNS37_RS06685 ENOG4105CIZ coA-substrate-specific enzyme activase HNS37_RS06695 ENOG4105CEY Amp-dependent synthetase and ligase HNS37_RS06700 ENOG4105C54 Major Facilitator superfamily HNS37_RS06705 ENOG4105WQV ferredoxin-like protein HNS37_RS06710 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HNS37_RS06730 ENOG4105C1G acyl-Coa dehydrogenase HNS37_RS06735 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HNS37_RS06740 ENOG4105CEY Amp-dependent synthetase and ligase HNS37_RS06745 ENOG4106YT9 Enoyl-CoA hydratase HNS37_RS06755 ENOG4108XNW Transcriptional activatory protein CaiF HNS37_RS06760 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HNS37_RS06765 ENOG4108M1A Chitin-binding protein HNS37_RS06805 ENOG4105DEQ transcriptional regulator HNS37_RS06810 ENOG4105Y3E Modulates RecA activity (By similarity) HNS37_RS06830 ENOG4108UR8 BAX protein HNS37_RS06835 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HNS37_RS06855 ENOG4105C6Z Gluconate HNS37_RS06860 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HNS37_RS06865 ENOG4105DIQ Transcriptional regulator HNS37_RS06870 ENOG4105S10 periplasmic binding protein HNS37_RS06875 ENOG4105EHG Permease protein HNS37_RS06880 ENOG4105E0A ABC, transporter HNS37_RS06885 ENOG4108BSC Methyltransferase HNS37_RS06890 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HNS37_RS06915 ENOG4108Z19 type iii secretion HNS37_RS06920 ENOG4108M6W surface presentation of antigens protein SpaS HNS37_RS06925 ENOG4108TN6 type iii secretion HNS37_RS06930 ENOG4105U07 type iii secretion HNS37_RS06935 ENOG41075IY surface presentation of antigens protein SpaP HNS37_RS06955 ENOG4108JIR Flagellum-specific ATP synthase HNS37_RS06965 ENOG4108HR8 type iii secretion HNS37_RS06970 ENOG4108N8R Invasion protein HNS37_RS06980 ENOG41090HZ type iii secretion HNS37_RS06990 ENOG4105Y7Q type iii secretion HNS37_RS07000 ENOG4108RBT type iii secretion HNS37_RS07020 ENOG4108Z4X TRANSCRIPTIONal HNS37_RS07030 ENOG4107X8C Efflux transporter RND family MFP subunit HNS37_RS07035 ENOG4105BZS acriflavin resistance protein HNS37_RS07060 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HNS37_RS07065 ENOG4105KNY Microcompartments protein HNS37_RS07070 ENOG4105F1A Pyruvate formate-lyase HNS37_RS07075 ENOG4105C6N Formate acetyltransferase HNS37_RS07090 ENOG4105C0A alcohol dehydrogenase HNS37_RS07095 ENOG4105KNY Microcompartments protein HNS37_RS07100 ENOG4105KNY Microcompartments protein HNS37_RS07105 ENOG4105KNY Microcompartments protein HNS37_RS07135 ENOG4108WDE Fimbrial protein HNS37_RS07140 ENOG4108AF8 Chaperone HNS37_RS07145 ENOG4105CW0 outer membrane usher protein HNS37_RS07150 ENOG4108SQA Fimbrial HNS37_RS07165 ENOG4108HM4 ABC transporter HNS37_RS07170 ENOG4105D38 putrescine abc transporter HNS37_RS07190 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HNS37_RS07195 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HNS37_RS07200 ENOG4105CDU Replicative dna helicase HNS37_RS07205 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HNS37_RS07210 ENOG4105CGF Aromatic amino acid aminotransferase HNS37_RS07220 ENOG4105C44 Serine transporter HNS37_RS07225 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HNS37_RS07230 ENOG4108UUM single-stranded DNA-binding protein HNS37_RS07235 ENOG4105MYN Zinc uptake regulation protein HNS37_RS07240 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HNS37_RS07245 ENOG41080IJ Diacylglycerol kinase HNS37_RS07250 ENOG4105E55 glycerol-3-phosphate acyltransferase HNS37_RS07255 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HNS37_RS07260 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HNS37_RS07265 ENOG4107QP8 phosphohexose isomerase HNS37_RS07270 ENOG4105CFH Aspartokinase HNS37_RS07285 ENOG4105C3R Methionine synthase HNS37_RS07290 ENOG41069M3 Transcriptional regulator HNS37_RS07295 ENOG4105C01 Dihydroxy-acid dehydratase HNS37_RS07300 ENOG4108UHU Aldolase HNS37_RS07305 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HNS37_RS07310 ENOG4108I9X Isocitrate lyase HNS37_RS07315 ENOG4107QP3 malate synthase g HNS37_RS07320 ENOG4105CVG Homoserine O-transsuccinylase HNS37_RS07360 ENOG4105DC1 bifunctional purine biosynthesis protein purh HNS37_RS07365 ENOG4105C12 Phosphoribosylglycinamide synthetase HNS37_RS07370 ENOG4108T8B Protein of unknown function (DUF1481) HNS37_RS07380 ENOG4105R2J Conserved Protein HNS37_RS07385 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HNS37_RS07390 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HNS37_RS07395 ENOG4105E09 nadh pyrophosphatase HNS37_RS07405 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HNS37_RS07410 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HNS37_RS07415 ENOG4105D06 uba thif-type nad fad binding protein HNS37_RS07420 ENOG4105WHD thiamine biosynthesis protein ThiS HNS37_RS07425 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HNS37_RS07430 ENOG4105D41 biosynthesis protein thiH HNS37_RS07435 ENOG4105DNE Transposase HNS37_RS07440 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HNS37_RS07445 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HNS37_RS07450 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HNS37_RS07455 ENOG4108VZM 50s ribosomal protein L10 HNS37_RS07460 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HNS37_RS07465 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HNS37_RS07470 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HNS37_RS07475 ENOG4105PM1 preprotein translocase subunit SecE HNS37_RS07480 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HNS37_RS07485 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HNS37_RS07490 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HNS37_RS07495 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HNS37_RS07505 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HNS37_RS07510 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HNS37_RS07515 ENOG4105WWK YheO domain protein HNS37_RS07525 ENOG4108V1T peptidylprolyl cis-trans isomerase HNS37_RS07530 ENOG4105VRX Protein slyX homolog HNS37_RS07535 ENOG4108YZY peptidylprolyl cis-trans isomerase HNS37_RS07540 ENOG4105VKU nucleicacid-binding protein HNS37_RS07550 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HNS37_RS07555 ENOG4105C5H ABC transporter HNS37_RS07560 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS07565 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS07570 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HNS37_RS07575 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HNS37_RS07585 ENOG4105DNZ Alpha Beta Hydrolase HNS37_RS07590 ENOG4105YP7 UPF0270 protein HNS37_RS07595 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HNS37_RS07600 ENOG4108UKZ OsmC family HNS37_RS07610 ENOG4105C8Y Acetylornithine aminotransferase HNS37_RS07620 ENOG4105D7V transposase HNS37_RS07625 ENOG4108RS6 transposase HNS37_RS07630 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HNS37_RS07640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HNS37_RS07645 ENOG4105C2M dna polymerase I HNS37_RS07655 ENOG4108Z33 Thiol disulfide Interchange Protein HNS37_RS07660 ENOG4105E27 serine threonine protein kinase HNS37_RS07665 ENOG4105PC1 Conserved Protein HNS37_RS07670 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HNS37_RS07675 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HNS37_RS07680 ENOG4105CG3 alpha amylase, catalytic region HNS37_RS07690 ENOG4105MWK D-amino acid dehydrogenase, small subunit HNS37_RS07695 ENOG4105DC8 reductase HNS37_RS07700 ENOG4105D6S protein involved in catabolism of external DNA HNS37_RS07710 ENOG4107H3J ribonuclease HNS37_RS07715 ENOG4105VSH 4-oxalocrotonate tautomerase HNS37_RS07720 ENOG4105CS0 peptidase HNS37_RS07725 ENOG4105BZU Histidine kinase HNS37_RS07730 ENOG4105CKT filamentous hemagglutinin HNS37_RS07735 ENOG4108JQ7 (ABC) transporter HNS37_RS07740 ENOG4105C3U ABC transporter HNS37_RS07745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNS37_RS07750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HNS37_RS07755 ENOG4105DEF Extracellular solute-binding protein, family 5 HNS37_RS07760 ENOG4105D5K Hemolysin activator protein HNS37_RS07775 ENOG4105R2A (LipO)protein HNS37_RS07780 ENOG4105D0C transport protein HNS37_RS07785 ENOG4105JKW Valine--pyruvate aminotransferase HNS37_RS07790 ENOG4108R3E Dna-3-methyladenine glycosylase i HNS37_RS07795 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HNS37_RS07800 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HNS37_RS07815 ENOG4105D99 atp gtp-binding protein HNS37_RS07820 ENOG4105EN6 Membrane HNS37_RS07825 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HNS37_RS07830 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HNS37_RS07835 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HNS37_RS07840 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HNS37_RS07845 ENOG4105CB5 ATP-dependent DNA helicase recG HNS37_RS07850 ENOG4105D6U Sodium Glutamate Symporter HNS37_RS07855 ENOG4105C2W permease HNS37_RS07860 ENOG4105JV1 AsmA family HNS37_RS07870 ENOG4105FE9 pseudouridine synthase HNS37_RS07875 ENOG4105SUU thioesterase domain HNS37_RS07880 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HNS37_RS07885 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HNS37_RS07910 ENOG4105CI3 gtp-binding protein typa HNS37_RS07930 ENOG4105D4P Coproporphyrinogen iii oxidase HNS37_RS07935 ENOG4107Y60 (LipO)protein HNS37_RS07945 ENOG4106B0W Curli production assembly transport component CsgG HNS37_RS07950 ENOG4105BZM domain protein HNS37_RS07955 ENOG4108RRZ Transcription elongation factor GreB HNS37_RS07965 ENOG4105E0F Histidine kinase HNS37_RS07970 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HNS37_RS07975 ENOG4105C8U phosphate abc transporter HNS37_RS07980 ENOG4105E2Z phosphate ABC transporter (Permease HNS37_RS07990 ENOG4108UTW Plays a role in the regulation of phosphate uptake HNS37_RS07995 ENOG4105CT1 (ABC) transporter HNS37_RS08000 ENOG4105E5Q amino acid AbC transporter HNS37_RS08005 ENOG4105DRP amino acid AbC transporter HNS37_RS08030 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HNS37_RS08045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HNS37_RS08050 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HNS37_RS08055 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HNS37_RS08060 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HNS37_RS08070 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HNS37_RS08080 ENOG4105C7N Xanthine uracil vitamin C permease HNS37_RS08085 ENOG4105D9U N-acetyltransferase HNS37_RS08105 ENOG4105XFK Ferrous iron transport protein A HNS37_RS08110 ENOG4105CE1 Ferrous iron transport protein b HNS37_RS08115 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HNS37_RS08125 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HNS37_RS08130 ENOG4105MJ2 Competence protein HNS37_RS08135 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HNS37_RS08140 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HNS37_RS08145 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HNS37_RS08150 ENOG4105E98 transcriptional regulator DeoR family HNS37_RS08155 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HNS37_RS08160 ENOG4105K78 MarR family Transcriptional regulator HNS37_RS08165 ENOG4105SYT Methylenetetrahydrofolate reductase HNS37_RS08190 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HNS37_RS08200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HNS37_RS08220 ENOG4108S9F abc transporter, atp-binding protein HNS37_RS08235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HNS37_RS08240 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HNS37_RS08245 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HNS37_RS08255 ENOG4108T1M outer membrane protein x HNS37_RS08260 ENOG410901P UPF0249 protein HNS37_RS08265 ENOG4105F8D glycoside hydrolase family 4 HNS37_RS08270 ENOG4105EZV Transcriptional regulator HNS37_RS08275 ENOG4105VCP PTS System HNS37_RS08280 ENOG4105CK1 PTS System HNS37_RS08285 ENOG4105VZJ PTS System HNS37_RS08295 ENOG4105DHS permease protein HNS37_RS08300 ENOG4105CM4 permease protein HNS37_RS08305 ENOG4108IPW abc transporter atp-binding protein HNS37_RS08315 ENOG4105DJB Major Facilitator Superfamily HNS37_RS08320 ENOG4105CXK mandelate racemase muconate lactonizing HNS37_RS08325 ENOG4105DRR Transcriptional regulator, GntR family HNS37_RS08335 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HNS37_RS08340 ENOG4108UHU Aldolase HNS37_RS08355 ENOG4105D5Q Arginine ornithine antiporter HNS37_RS08360 ENOG4105CXN decarboxylase HNS37_RS08365 ENOG4105D5Q Arginine ornithine antiporter HNS37_RS08375 ENOG4107QY8 reductase HNS37_RS08380 ENOG4105QAX Iron-sulfur HNS37_RS08385 ENOG4107KGK dmso reductase anchor subunit HNS37_RS08390 ENOG4105ETE Transcriptional regulator (LacI family HNS37_RS08400 ENOG4105EAA nucleoside HNS37_RS08405 ENOG4105KT7 mgtC SapB transporter HNS37_RS08425 ENOG4105QEK Transcriptional regulator HNS37_RS08430 ENOG4108R66 Conserved Protein HNS37_RS08435 ENOG4107RJ1 sodium solute HNS37_RS08445 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HNS37_RS08450 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HNS37_RS08455 ENOG4105C8J )-transporter HNS37_RS08465 ENOG4105CI1 PTS System HNS37_RS08470 ENOG4108Q3X Transcriptional regulator HNS37_RS08480 ENOG4105D3G Pseudouridine synthase HNS37_RS08485 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HNS37_RS08490 ENOG4105N1F Hnh endonuclease HNS37_RS08495 ENOG4108WC9 type VI secretion system effector, hcp1 family HNS37_RS08500 ENOG4105CS6 Rhs element vgr protein HNS37_RS08535 ENOG4106PYX Receptor HNS37_RS08540 ENOG4108N3D putative enzyme HNS37_RS08625 ENOG4105DFP Integrase HNS37_RS08635 ENOG4105DGW oligopeptidase A HNS37_RS08640 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HNS37_RS08645 ENOG4108R85 Short chain dehydrogenase HNS37_RS08650 ENOG4105D82 Glutamate dehydrogenase HNS37_RS08655 ENOG4108M6U Universal stress protein A HNS37_RS08660 ENOG4108V6B universal stress protein B HNS37_RS08665 ENOG4105CJ3 phosphate transporter HNS37_RS08670 ENOG4105CBX hi0933 family HNS37_RS08680 ENOG4108WC9 type VI secretion system effector, hcp1 family HNS37_RS08685 ENOG4105C2I pirin domain protein HNS37_RS08690 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HNS37_RS08695 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HNS37_RS08700 ENOG4105VEJ Heat shock protein HNS37_RS08705 ENOG4105DQY intracellular growth attenuator HNS37_RS08710 ENOG4107RK2 ADP-ribose diphosphatase NudE HNS37_RS08715 ENOG4105D01 (LipO)protein HNS37_RS08720 ENOG4108JQC penicillin-binding protein 1A HNS37_RS08740 ENOG4105E4G Type IV pilus HNS37_RS08745 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HNS37_RS08750 ENOG4105D49 3-dehydroquinate synthase HNS37_RS08765 ENOG4105DJV ribulose-phosphate 3-epimerase HNS37_RS08770 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HNS37_RS08775 ENOG4105C31 Tryptophanyl-tRNA synthetase HNS37_RS08780 ENOG4108RPX mosc domain containing protein HNS37_RS08785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HNS37_RS08790 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HNS37_RS08795 ENOG41062QD Membrane HNS37_RS08800 ENOG4107QN1 sodium solute HNS37_RS08805 ENOG4105DIJ Phosphoethanolamine transferase HNS37_RS08810 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HNS37_RS08815 ENOG4107QR9 Iron-sulfur cluster binding protein HNS37_RS08820 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HNS37_RS08845 ENOG4107EJG GntR family transcriptional regulator HNS37_RS08850 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNS37_RS08855 ENOG4108RVA ribokinase HNS37_RS08860 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HNS37_RS08865 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HNS37_RS08870 ENOG4105CU9 asparagine synthetase A HNS37_RS08875 ENOG4108VVK transcriptional Regulator, AsnC HNS37_RS08880 ENOG4105QTB Flavodoxin HNS37_RS08885 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HNS37_RS08890 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HNS37_RS08895 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HNS37_RS08900 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HNS37_RS08905 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HNS37_RS08910 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HNS37_RS08915 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HNS37_RS08920 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HNS37_RS08925 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HNS37_RS08930 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HNS37_RS08935 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HNS37_RS08940 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HNS37_RS08945 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HNS37_RS08975 ENOG4108BUD transposase HNS37_RS08995 ENOG4108BUD transposase HNS37_RS09005 ENOG4108BUD transposase HNS37_RS09085 ENOG4108BUD transposase HNS37_RS09120 ENOG4108BUD transposase HNS37_RS09140 ENOG4108BUD transposase HNS37_RS09160 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HNS37_RS09165 ENOG4105EPC oxidoreductase HNS37_RS09170 ENOG4105VF7 tolerance protein HNS37_RS09175 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HNS37_RS09200 ENOG4108BUD transposase HNS37_RS09255 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS09265 ENOG4105C4Y ABC transporter HNS37_RS09270 ENOG41080HI glycine oxidase HNS37_RS09285 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HNS37_RS09330 ENOG4105E6S usher protein( HNS37_RS09355 ENOG4105H4F exported protein HNS37_RS09365 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HNS37_RS09375 ENOG4107QZ7 Cellulose synthase catalytic subunit HNS37_RS09385 ENOG4105EJG cellulose synthase HNS37_RS09395 ENOG4105BZU Histidine kinase HNS37_RS09400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HNS37_RS09405 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HNS37_RS09410 ENOG4107T7U Sulfatase HNS37_RS09415 ENOG4105EM7 Selenocysteine-specific translation elongation factor HNS37_RS09420 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HNS37_RS09425 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HNS37_RS09430 ENOG4108MG3 formate dehydrogenase HNS37_RS09435 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HNS37_RS09445 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HNS37_RS09470 ENOG4106P55 Transcriptional regulator HNS37_RS09490 ENOG41067XB TonB family HNS37_RS09505 ENOG4108UQ5 membrane protein YcdZ HNS37_RS09515 ENOG4108YUH HNS37_RS09585 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNS37_RS09590 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HNS37_RS09595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HNS37_RS09600 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HNS37_RS09605 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HNS37_RS09610 ENOG4105VG0 50S ribosomal protein l34 HNS37_RS09615 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HNS37_RS09620 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HNS37_RS09625 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HNS37_RS09630 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNS37_RS09635 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HNS37_RS09640 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HNS37_RS09660 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HNS37_RS09675 ENOG4105DSJ YicC domain protein HNS37_RS09680 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HNS37_RS09685 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HNS37_RS09690 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HNS37_RS09695 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HNS37_RS09700 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HNS37_RS09705 ENOG4105W5Q DNA repair protein (RadC HNS37_RS09710 ENOG4105KDC 50s ribosomal protein l28 HNS37_RS09715 ENOG4105W0E 50S ribosomal protein L33 HNS37_RS09720 ENOG4105CPK Glycosyl transferase (Group 1 HNS37_RS09730 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HNS37_RS09740 ENOG4108FRV O-antigen ligase HNS37_RS09745 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HNS37_RS09750 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HNS37_RS09760 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HNS37_RS09765 ENOG4105DKP glycosyl transferase, family 9 HNS37_RS09775 ENOG4105CPK Glycosyl transferase (Group 1 HNS37_RS09780 ENOG4108XNZ glycosyl transferase HNS37_RS09785 ENOG4107XU6 Glycosyl transferase (Group 1 HNS37_RS09800 ENOG4105D16 lipopolysaccharide heptosyltransferase i HNS37_RS09805 ENOG4105XA0 heptosyltransferase ii HNS37_RS09810 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HNS37_RS09815 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HNS37_RS09820 ENOG4105CPQ Dehydrogenase HNS37_RS09825 ENOG4105PXI polysaccharide deacetylase HNS37_RS09830 ENOG41063SB peptidase HNS37_RS09835 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HNS37_RS09845 ENOG4107YZP Rhodanese domain protein HNS37_RS09850 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HNS37_RS09860 ENOG4105D7W serine acetyltransferase HNS37_RS09865 ENOG4105D7W serine acetyltransferase HNS37_RS09870 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HNS37_RS09905 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HNS37_RS09935 ENOG4105E0F Histidine kinase HNS37_RS09940 ENOG4105E3W Two component transcriptional regulator (Winged helix family HNS37_RS09945 ENOG4105FMW periplasmic HNS37_RS09950 ENOG4105W08 virulence gene repressor rsal HNS37_RS09955 ENOG4105CHR reductase HNS37_RS09960 ENOG4105CTQ phosphohexokinase HNS37_RS09965 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HNS37_RS09970 ENOG4105CP7 Triose-phosphate isomerase HNS37_RS09975 ENOG4105EBK exported protein HNS37_RS09980 ENOG4108VTS Membrane HNS37_RS09985 ENOG4105DP0 ferredoxin-NADP reductase HNS37_RS09990 ENOG4105E5M Multidrug resistance protein D HNS37_RS09995 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HNS37_RS10000 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HNS37_RS10005 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HNS37_RS10015 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HNS37_RS10020 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HNS37_RS10025 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HNS37_RS10030 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HNS37_RS10035 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HNS37_RS10040 ENOG41063M6 Cell Division Protein HNS37_RS10045 ENOG4105ETE Transcriptional regulator (LacI family HNS37_RS10050 ENOG4105C25 Primosomal protein n' HNS37_RS10055 ENOG41082DI 50s ribosomal protein l31 HNS37_RS10065 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HNS37_RS10070 ENOG4105C28 cystathionine HNS37_RS10075 ENOG4105CFH Aspartokinase HNS37_RS10080 ENOG4108TEB UPF0114 protein HNS37_RS10090 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HNS37_RS10095 ENOG4105K64 Glycosyl transferase, family 2 HNS37_RS10100 ENOG4105CVP deoxyribo-dipyrimidine photolyase HNS37_RS10105 ENOG4105CSH Transporter HNS37_RS10110 ENOG4107R11 Transcriptional regulator HNS37_RS10130 ENOG4105C7K acetolactate synthase HNS37_RS10135 ENOG4105CWC Acetylornithine deacetylase HNS37_RS10140 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HNS37_RS10145 ENOG4105CAS nag kinase HNS37_RS10150 ENOG4105CDH Citrulline--aspartate ligase HNS37_RS10155 ENOG4105CH7 arginosuccinase HNS37_RS10160 ENOG4105C5Q Transcriptional regulator HNS37_RS10165 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HNS37_RS10175 ENOG4108Y73 Membrane HNS37_RS10180 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HNS37_RS10185 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HNS37_RS10190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HNS37_RS10225 ENOG4105D4A Cell wall formation (By similarity) HNS37_RS10230 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HNS37_RS10235 ENOG4105CS9 pantothenic acid kinase HNS37_RS10260 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HNS37_RS10280 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HNS37_RS10285 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HNS37_RS10290 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HNS37_RS10295 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HNS37_RS10300 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HNS37_RS10305 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HNS37_RS10315 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HNS37_RS10320 ENOG41083MP 50s ribosomal protein l29 HNS37_RS10325 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HNS37_RS10330 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HNS37_RS10335 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HNS37_RS10340 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HNS37_RS10345 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HNS37_RS10350 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HNS37_RS10355 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HNS37_RS10360 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HNS37_RS10365 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HNS37_RS10370 ENOG4105VPB 50S ribosomal protein L30 HNS37_RS10375 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HNS37_RS10380 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HNS37_RS10385 ENOG41067V7 50S ribosomal protein L36 HNS37_RS10390 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HNS37_RS10395 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HNS37_RS10400 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HNS37_RS10410 ENOG4108ZT0 50S ribosomal protein l17 HNS37_RS10415 ENOG4105W1Y Transcriptional regulator HNS37_RS10420 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HNS37_RS10425 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HNS37_RS10430 ENOG4105C1A potassium transporter peripheral membrane HNS37_RS10435 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HNS37_RS10440 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HNS37_RS10445 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HNS37_RS10450 ENOG4105C79 DNA protecting protein DprA HNS37_RS10455 ENOG4108WI1 Dna topoisomerase HNS37_RS10460 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HNS37_RS10465 ENOG4105E2X shikimate dehydrogenase HNS37_RS10470 ENOG4105SG3 Protein of unknown function (DUF1488) HNS37_RS10475 ENOG4108Z0R Transferase HNS37_RS10515 ENOG4105CVI Transcriptional regulator HNS37_RS10520 ENOG4108WFC UPF0438 protein yifE HNS37_RS10525 ENOG4105C0P Mg chelatase subunit ChlI HNS37_RS10540 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HNS37_RS10545 ENOG4105CM2 brancheD-chain amino acid aminotransferase HNS37_RS10550 ENOG4105C01 Dihydroxy-acid dehydratase HNS37_RS10555 ENOG4105C7B Threonine dehydratase HNS37_RS10560 ENOG4105EMY transcriptional regulator HNS37_RS10565 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HNS37_RS10580 ENOG4105C4R Atp-dependent dna helicase HNS37_RS10585 ENOG4105C9X ppx gppa phosphatase HNS37_RS10590 ENOG4105C1J atp-dependent rna helicase HNS37_RS10600 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HNS37_RS10605 ENOG4105ESV Glycosyl transferase, family 4 HNS37_RS10610 ENOG4105SFE lipopolysaccharide biosynthesis protein HNS37_RS10615 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HNS37_RS10620 ENOG4108IJ1 Dehydrogenase HNS37_RS10625 ENOG4105C1B dTDP-glucose 4-6-dehydratase HNS37_RS10630 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HNS37_RS10635 ENOG4108WJ1 acetyltransferase HNS37_RS10640 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HNS37_RS10645 ENOG4105EGZ biosynthesis protein HNS37_RS10650 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HNS37_RS10655 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HNS37_RS10660 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HNS37_RS10690 ENOG410601J HemY protein HNS37_RS10695 ENOG4105ECF c-methyltransferase HNS37_RS10705 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HNS37_RS10710 ENOG4107T0K Adenylate cyclase HNS37_RS10715 ENOG4105XQ6 frataxin-like protein HNS37_RS10720 ENOG4105S7Z (LipO)protein HNS37_RS10725 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HNS37_RS10730 ENOG4105CT0 Protein of unknown function, DUF484 HNS37_RS10735 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNS37_RS10740 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HNS37_RS10745 ENOG4105C4R Atp-dependent dna helicase HNS37_RS10755 ENOG4105FR1 rard protein HNS37_RS10760 ENOG4108VUY thioesterase Superfamily protein HNS37_RS10765 ENOG4105HDD phospholipase HNS37_RS10770 ENOG4105C9U ATP-dependent DNA helicase RecQ HNS37_RS10775 ENOG4108EUD Lysophospholipase HNS37_RS10780 ENOG4105DQF Hydrolase HNS37_RS10790 ENOG4105CW0 outer membrane usher protein HNS37_RS10795 ENOG4108AF8 Chaperone HNS37_RS10800 ENOG4108S54 Fimbrial protein HNS37_RS10810 ENOG4105EGS Mechanosensitive ion channel HNS37_RS10815 ENOG4105DJ4 phosphatidylserine decarboxylase HNS37_RS10820 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HNS37_RS10825 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HNS37_RS10845 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HNS37_RS10850 ENOG4105K8N protein family UPF0079, ATPase HNS37_RS10855 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HNS37_RS10860 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HNS37_RS10865 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HNS37_RS10870 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HNS37_RS10875 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HNS37_RS10880 ENOG4107QJR hflk protein HNS37_RS10885 ENOG4105EPW hflc protein HNS37_RS10890 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HNS37_RS10895 ENOG4105KPV Transcriptional regulator HNS37_RS10900 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HNS37_RS10905 ENOG4105C2N RNA methyltransferase TrmH family group 3 HNS37_RS10910 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HNS37_RS10915 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HNS37_RS10920 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HNS37_RS10925 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HNS37_RS10930 ENOG4105FHY Opacity-associated protein A HNS37_RS10935 ENOG4105NRA 50s ribosomal protein l31 type b HNS37_RS10940 ENOG4105YK5 50S ribosomal protein L36 HNS37_RS10945 ENOG4108MEK Metal-binding protein YodA HNS37_RS10955 ENOG4105C26 Dehydrogenase HNS37_RS10960 ENOG4108V1T peptidylprolyl cis-trans isomerase HNS37_RS10965 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HNS37_RS10970 ENOG4108UUE Transcriptional regulator HNS37_RS10975 ENOG41061GZ Protein of unknown function (DUF1107) HNS37_RS10980 ENOG4105C37 (CBS) domain HNS37_RS10985 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HNS37_RS10990 ENOG4105CFU surface antigen HNS37_RS10995 ENOG4105MA0 exported protein HNS37_RS11000 ENOG4108ZHD aig2 family HNS37_RS11020 ENOG4105F0N pyrophosphate phospho-hydrolase HNS37_RS11025 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HNS37_RS11030 ENOG4105DFU Cell wall formation (By similarity) HNS37_RS11035 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HNS37_RS11040 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HNS37_RS11045 ENOG4105HVQ Regulatory factor of maltose metabolism HNS37_RS11060 ENOG4105EAH synthase HNS37_RS11065 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HNS37_RS11070 ENOG4105K46 50S ribosomal protein l27 HNS37_RS11075 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HNS37_RS11080 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HNS37_RS11085 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HNS37_RS11090 ENOG4105HBR Rna-binding protein HNS37_RS11095 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HNS37_RS11100 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HNS37_RS11105 ENOG4105EEI dihydropteroate synthase HNS37_RS11110 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HNS37_RS11115 ENOG4105NTZ Preprotein translocase subunit SecG HNS37_RS11130 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HNS37_RS11135 ENOG4105CHV Transcription elongation factor NusA HNS37_RS11140 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HNS37_RS11145 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HNS37_RS11150 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HNS37_RS11155 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HNS37_RS11160 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HNS37_RS11170 ENOG4105C1J atp-dependent rna helicase HNS37_RS11185 ENOG4108NEV two component transcriptional regulator, LytTR family HNS37_RS11190 ENOG4108HRK Histidine kinase HNS37_RS11195 ENOG4105J12 Multidrug resistance protein mdtN HNS37_RS11225 ENOG4108YYD acetyltransferase HNS37_RS11230 ENOG41082IR Excinuclease ABC C subunit domain protein HNS37_RS11235 ENOG4105ZY9 UPF0379 protein ybiM HNS37_RS11255 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HNS37_RS11260 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HNS37_RS11265 ENOG4105KME endoribonuclease L-psp HNS37_RS11270 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HNS37_RS11275 ENOG4105CXT aspartate transcarbamylase HNS37_RS11285 ENOG4105DBV ornithine carbamoyltransferase HNS37_RS11295 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HNS37_RS11300 ENOG4105EUB pirin domain protein HNS37_RS11305 ENOG4105VYH HNS37_RS11310 ENOG4108MJ3 acetyltransferase HNS37_RS11315 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HNS37_RS11320 ENOG4105MYG DNA polymerase iii, chi subunit HNS37_RS11325 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HNS37_RS11330 ENOG4108M8S permease YjgP YjgQ family protein HNS37_RS11335 ENOG4108K5H permease YjgP YjgQ family protein HNS37_RS11340 ENOG4107R6D beta-lactam binding protein AmpH HNS37_RS11350 ENOG4105DFP Integrase HNS37_RS11385 ENOG4108S2Y peptide Chain Release factor HNS37_RS11395 ENOG4107FB0 transcriptional regulator DeoR family HNS37_RS11400 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HNS37_RS11410 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HNS37_RS11420 ENOG4105HX0 Transcriptional regulator HNS37_RS11435 ENOG4105C7K acetolactate synthase HNS37_RS11440 ENOG4105M71 acetolactate synthase 1 regulatory subunit HNS37_RS11460 ENOG4105C7N Xanthine uracil vitamin C permease HNS37_RS11465 ENOG4108MK9 spermidine N(1)-acetyltransferase HNS37_RS11470 ENOG4105EEQ Na H antiporter HNS37_RS11475 ENOG4105EMK carboxylate amino acid amine transporter HNS37_RS11480 ENOG4105DZ2 Transcriptional regulator HNS37_RS11485 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HNS37_RS11495 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HNS37_RS11500 ENOG4107SXA Phosphorylase HNS37_RS11510 ENOG4108KF1 Membrane HNS37_RS11515 ENOG4105CGY Dna recombination protein HNS37_RS11520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HNS37_RS11525 ENOG4105JC1 sterol-binding domain protein HNS37_RS11530 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HNS37_RS11535 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HNS37_RS11540 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HNS37_RS11545 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HNS37_RS11550 ENOG4105MDZ Transcriptional activator rfaH HNS37_RS11555 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) HNS37_RS11560 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HNS37_RS11570 ENOG4105CHU acetyl-coa acetyltransferase HNS37_RS11575 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HNS37_RS11580 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HNS37_RS11585 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HNS37_RS11590 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HNS37_RS11595 ENOG4108RR8 protoporphyrinogen oxidase HNS37_RS11625 ENOG4105C5A transporter HNS37_RS11630 ENOG4105E7W lamb ycsf family protein HNS37_RS11635 ENOG4105P4J Allophanate hydrolase, subunit 1 HNS37_RS11640 ENOG4108JIK carboxylase HNS37_RS11645 ENOG4105HF0 Membrane HNS37_RS11660 ENOG4105HEI LysR family (Transcriptional regulator HNS37_RS11665 ENOG4105WH1 Two component transcriptional regulator luxr family HNS37_RS11670 ENOG4105BZU Histidine kinase HNS37_RS11675 ENOG4105DQQ Major facilitator superfamily MFS_1 HNS37_RS11680 ENOG4105CRU nitrate reductase, alpha subunit HNS37_RS11685 ENOG4108IUE nitrate reductase beta subunit HNS37_RS11690 ENOG4105R3A Nitrate reductase HNS37_RS11695 ENOG41076YT nitrate reductase, gamma subunit HNS37_RS11705 ENOG4105DIJ Phosphoethanolamine transferase HNS37_RS11720 ENOG4108JUA Transcriptional regulator HNS37_RS11745 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HNS37_RS11750 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HNS37_RS11765 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HNS37_RS11770 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HNS37_RS11775 ENOG4105CXY transporter HNS37_RS11780 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HNS37_RS11790 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HNS37_RS11800 ENOG4105EX9 Membrane HNS37_RS11805 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HNS37_RS11820 ENOG4105C59 p-type ATPase HNS37_RS11825 ENOG4107FS9 Membrane HNS37_RS11835 ENOG4105MG3 Membrane HNS37_RS11840 ENOG4106H78 methyltransferase HNS37_RS11845 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HNS37_RS11850 ENOG4105CAK Cell division ATP-binding protein ftsE HNS37_RS11855 ENOG4105CRP Part of the ABC transporter FtsEX involved in HNS37_RS11860 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNS37_RS11865 ENOG4105BZW Glycerate kinase HNS37_RS11870 ENOG4105U59 -acetyltransferase HNS37_RS11880 ENOG4108INS Transcriptional regulator HNS37_RS11885 ENOG4108K0D peptidase, M48 HNS37_RS11890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS11895 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HNS37_RS11905 ENOG4105BZ7 extracellular solute-binding protein family 1 HNS37_RS11910 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HNS37_RS11915 ENOG4105DJ2 Major Facilitator Superfamily HNS37_RS11930 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HNS37_RS11940 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HNS37_RS11945 ENOG4108IA2 Sodium pantothenate symporter HNS37_RS11950 ENOG4105RG0 Membrane HNS37_RS11955 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HNS37_RS11960 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HNS37_RS11965 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HNS37_RS11970 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HNS37_RS11980 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HNS37_RS11985 ENOG4105VQ7 Rod shape-determining protein MreD HNS37_RS11990 ENOG4108Z03 MAF-like protein HNS37_RS11995 ENOG4105C03 ribonuclease HNS37_RS12000 ENOG4105QD6 exported protein HNS37_RS12010 ENOG4105D1U peptidase U62 modulator of DNA gyrase HNS37_RS12020 ENOG41067XF inhibitor HNS37_RS12025 ENOG4105N42 UPF0307 protein HNS37_RS12030 ENOG4105CMS peptidase U62, modulator of DNA gyrase HNS37_RS12035 ENOG4105NXH GreA GreB family elongation factor HNS37_RS12040 ENOG41080Z8 PHOSPHOCARRIER protein HNS37_RS12045 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HNS37_RS12050 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HNS37_RS12055 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HNS37_RS12060 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNS37_RS12065 ENOG4108IUZ ABC transporter HNS37_RS12070 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HNS37_RS12075 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HNS37_RS12080 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HNS37_RS12085 ENOG4105C2X Arabinose 5-phosphate isomerase HNS37_RS12090 ENOG4105FEU K -dependent Na -Ca exchanger HNS37_RS12095 ENOG4105DHJ ABC, transporter HNS37_RS12100 ENOG4105CY3 ABC transporter, permease HNS37_RS12105 ENOG4107PE3 Mammalian cell entry related domain protein HNS37_RS12110 ENOG4105E3I toluene tolerance HNS37_RS12120 ENOG4105VFK BolA family HNS37_RS12125 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HNS37_RS12145 ENOG4105C0H protease HNS37_RS12150 ENOG4105C0H protease HNS37_RS12155 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HNS37_RS12160 ENOG4105D6Z AFG1 family ATPase HNS37_RS12165 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HNS37_RS12170 ENOG4108UJD 30S ribosomal protein S9 HNS37_RS12175 ENOG4107MKT Stringent starvation protein a HNS37_RS12180 ENOG4105KB2 stringent starvation protein b HNS37_RS12190 ENOG4105CH2 amidohydrolase HNS37_RS12200 ENOG4105BZ8 glutamate synthase HNS37_RS12205 ENOG4105CBC glutamate synthase HNS37_RS12210 ENOG4105BZU Histidine kinase HNS37_RS12215 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HNS37_RS12220 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HNS37_RS12225 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HNS37_RS12230 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HNS37_RS12235 ENOG4108YZ9 Urea amidohydrolase subunit gamma HNS37_RS12240 ENOG4105KI2 Urea amidohydrolase subunit beta HNS37_RS12245 ENOG4105CQM Urea amidohydrolase subunit alpha HNS37_RS12250 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HNS37_RS12255 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HNS37_RS12260 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HNS37_RS12265 ENOG4105W4M Transport-associated protein HNS37_RS12270 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HNS37_RS12275 ENOG41082RQ UPF0102 protein HNS37_RS12285 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HNS37_RS12295 ENOG4108CNN domain protein HNS37_RS12300 ENOG4105CWB LysR family transcriptional Regulator HNS37_RS12305 ENOG4108VBZ doxx family HNS37_RS12315 ENOG41090KG Inner membrane protein YqjE HNS37_RS12320 ENOG4105NE1 Conserved Protein HNS37_RS12325 ENOG4106W5V Membrane HNS37_RS12330 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HNS37_RS12335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HNS37_RS12345 ENOG4107RAN Peptidase, M16 HNS37_RS12350 ENOG4105CQ0 ABC transporter HNS37_RS12355 ENOG4105PE1 Receptor HNS37_RS12365 ENOG4108SF5 RNA Polymerase HNS37_RS12375 ENOG4105C5H ABC transporter HNS37_RS12380 ENOG4107SC1 transglycosylase HNS37_RS12385 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HNS37_RS12390 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HNS37_RS12395 ENOG4105CVJ phosphoglycerate mutase HNS37_RS12400 ENOG4105UEI Transcriptional Regulator AraC Family HNS37_RS12405 ENOG4108RH0 Crea protein HNS37_RS12410 ENOG41065U4 response regulator HNS37_RS12420 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HNS37_RS12435 ENOG4105D1Q UPF0246 protein HNS37_RS12440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HNS37_RS12460 ENOG4108RIR Molybdenum cofactor biosynthesis protein HNS37_RS12465 ENOG4105CFG Acts as a chaperone (By similarity) HNS37_RS12470 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HNS37_RS12480 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HNS37_RS12485 ENOG41063Z6 transcriptional regulator, lysR family HNS37_RS12490 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HNS37_RS12500 ENOG4105DTN riboflavin biosynthesis protein ribF HNS37_RS12505 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HNS37_RS12510 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HNS37_RS12515 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HNS37_RS12520 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HNS37_RS12525 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HNS37_RS12535 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HNS37_RS12545 ENOG4105TNG K13735 adhesin invasin HNS37_RS12550 ENOG4105CV8 reductase HNS37_RS12555 ENOG4108I6A alcohol dehydrogenase HNS37_RS12560 ENOG4108I0C methyltransferase HNS37_RS12565 ENOG4108K81 inner membrane protein YghB HNS37_RS12570 ENOG4105C28 cystathionine HNS37_RS12575 ENOG4105CWK Biopolymer transport protein, ExbB HNS37_RS12580 ENOG4108ZZF transport protein (ExbD) HNS37_RS12585 ENOG4105E3S small subunit HNS37_RS12590 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HNS37_RS12595 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HNS37_RS12600 ENOG4105DPX Hydrogenase, large subunit HNS37_RS12605 ENOG4108USZ hydrogenase HNS37_RS12610 ENOG4108WGS hydrogenase 2-specific chaperone HNS37_RS12615 ENOG4107RSS Hydrogenase accessory protein HypB HNS37_RS12620 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HNS37_RS12625 ENOG4105CQS hydrogenase expression formation protein HypD HNS37_RS12630 ENOG4105C45 hydrogenase expression formation protein (HypE) HNS37_RS12635 ENOG41066VF YeeE YedE family protein HNS37_RS12645 ENOG4105DH7 May be involved in recombination (By similarity) HNS37_RS12655 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HNS37_RS12660 ENOG41083KI ribonuclease, T2 HNS37_RS12665 ENOG4105CGH 5'-nucleotidase HNS37_RS12675 ENOG4105EYH Exonuclease HNS37_RS12680 ENOG4107RH8 nuclease SbcCD subunit D HNS37_RS12685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNS37_RS12690 ENOG4105BZU Histidine kinase HNS37_RS12695 ENOG4105CWM branched-chain amino acid transport system II carrier protein HNS37_RS12705 ENOG4108NWD Cytochrome HNS37_RS12710 ENOG4108393 oxidoreductase Fe-S subunit HNS37_RS12715 ENOG4105JVW HNS37_RS12720 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HNS37_RS12725 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HNS37_RS12735 ENOG4105D3R alkyl hydroperoxide reductase HNS37_RS12740 ENOG4108ZYK Acyl carrier protein phosphodiesterase HNS37_RS12745 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HNS37_RS12750 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HNS37_RS12755 ENOG4105VIE preprotein translocase, subunit YajC HNS37_RS12760 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HNS37_RS12765 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HNS37_RS12770 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HNS37_RS12775 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HNS37_RS12780 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HNS37_RS12785 ENOG4107YIM Involved in the transcription termination process (By similarity) HNS37_RS12790 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HNS37_RS12795 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HNS37_RS12810 ENOG4105ETE Transcriptional regulator (LacI family HNS37_RS12815 ENOG4108RVA ribokinase HNS37_RS12820 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HNS37_RS12825 ENOG4105CNN ABC, transporter HNS37_RS12830 ENOG4105C2J ABC transporter HNS37_RS12835 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HNS37_RS12840 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HNS37_RS12845 ENOG4105CTB Polyprenyl synthetase HNS37_RS12850 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HNS37_RS12855 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HNS37_RS12860 ENOG4107S0N DJ-1 family HNS37_RS12865 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HNS37_RS12870 ENOG4108VPT UPF0234 protein HNS37_RS12875 ENOG4107RDB Major Facilitator HNS37_RS12880 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HNS37_RS12885 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HNS37_RS12890 ENOG4105CCU oxidase (Subunit III) HNS37_RS12895 ENOG4105BZ9 Cytochrome C oxidase, subunit I HNS37_RS12900 ENOG4105E2S oxidase) subunit II HNS37_RS12905 ENOG4108NFH Sugar hydrolase HNS37_RS12910 ENOG4105C1J atp-dependent rna helicase HNS37_RS12915 ENOG4105EYM Major Facilitator superfamily HNS37_RS12920 ENOG4105IEY (LipO)protein HNS37_RS12925 ENOG4108RS6 transposase HNS37_RS12930 ENOG4105D7V transposase HNS37_RS12935 ENOG4105M85 Bola protein HNS37_RS12940 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HNS37_RS12945 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HNS37_RS12950 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HNS37_RS12955 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HNS37_RS12960 ENOG4105K70 DNA-binding protein HNS37_RS12965 ENOG4105EIN peptidylprolyl cis-trans isomerase HNS37_RS12970 ENOG4105KQC Competence protein HNS37_RS12975 ENOG4108TGP Thioesterase superfamily protein HNS37_RS12980 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HNS37_RS12985 ENOG4108XM1 transcriptional regulator AsnC family HNS37_RS12990 ENOG4105BZ1 (ABC) transporter HNS37_RS12995 ENOG4105BZ1 (ABC) transporter HNS37_RS13000 ENOG4108YZA Nitrogen regulatory protein pii HNS37_RS13005 ENOG4105BZU Histidine kinase HNS37_RS13010 ENOG4105C29 acyl-CoA thioesterase HNS37_RS13020 ENOG4105KF5 hemolysin expression-modulating protein HNS37_RS13030 ENOG4105BZS acriflavin resistance protein HNS37_RS13035 ENOG4105C1P efflux transporter, rnd family, mfp subunit HNS37_RS13040 ENOG4107XI7 Tetr family transcriptional regulator HNS37_RS13045 ENOG41090EX DsrE family HNS37_RS13050 ENOG4105EGS Mechanosensitive ion channel HNS37_RS13065 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HNS37_RS13070 ENOG4107QMP dna polymerase iii subunits gamma and tau HNS37_RS13075 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HNS37_RS13080 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HNS37_RS13085 ENOG4105D22 carbon starvation protein HNS37_RS13090 ENOG4105VCD cytoplasmic protein HNS37_RS13095 ENOG4105CKI cobalamin synthesis protein HNS37_RS13105 ENOG4105CEE C4-dicarboxylate transporter HNS37_RS13110 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HNS37_RS13120 ENOG4105UQX Mate efflux family protein HNS37_RS13125 ENOG4105DGA Diaminopimelate dehydrogenase HNS37_RS13135 ENOG4105EQN UPF0261 protein HNS37_RS13165 ENOG4108ZRK uncharacterized protein yacC HNS37_RS13170 ENOG4105E3B Multicopper oxidase HNS37_RS13175 ENOG4108UGV hypoxanthine phosphoribosyltransferase HNS37_RS13180 ENOG41077A9 carbonic anhydrase HNS37_RS13185 ENOG4105DA5 (ABC) transporter HNS37_RS13190 ENOG4105E3A (ABC) transporter HNS37_RS13195 ENOG41079KZ Major Facilitator Superfamily HNS37_RS13200 ENOG4105R71 cytoplasmic protein HNS37_RS13205 ENOG4105D0M Protease HtpX homolog HNS37_RS13220 ENOG4105QAX Iron-sulfur HNS37_RS13225 ENOG4108J2R molybdopterin oxidoreductase HNS37_RS13235 ENOG4105DBE peroxidase HNS37_RS13250 ENOG4105WP5 HNS37_RS13265 ENOG4106032 Glutathionylspermidine synthase HNS37_RS13270 ENOG4105W8I Transcriptional regulator HNS37_RS13275 ENOG4105C6Z Gluconate HNS37_RS13280 ENOG4105BZC d-serine deaminase HNS37_RS13285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS13290 ENOG4107RCV ABC transporter, permease HNS37_RS13295 ENOG4105C4Y ABC transporter HNS37_RS13300 ENOG4105CXY transporter HNS37_RS13305 ENOG4105BZU Histidine kinase HNS37_RS13310 ENOG4108KX4 response regulator HNS37_RS13315 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HNS37_RS13320 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HNS37_RS13325 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HNS37_RS13330 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HNS37_RS13335 ENOG4105DJ0 Poly(A) Polymerase HNS37_RS13345 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HNS37_RS13350 ENOG4105PW4 Sugar fermentation stimulation protein homolog HNS37_RS13355 ENOG4105CQ7 ATP-dependent helicase HNS37_RS13360 ENOG4105BZ4 penicillin-binding protein HNS37_RS13365 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HNS37_RS13370 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HNS37_RS13380 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HNS37_RS13390 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HNS37_RS13395 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HNS37_RS13400 ENOG4105DXN mazG family HNS37_RS13405 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HNS37_RS13410 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HNS37_RS13415 ENOG4105C8P )-transporter HNS37_RS13420 ENOG4107RA9 decarboxylase HNS37_RS13425 ENOG4105E9H Lytic Murein transglycosylase HNS37_RS13430 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HNS37_RS13435 ENOG4105D1A Methyltransferase HNS37_RS13440 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HNS37_RS13445 ENOG4107RZZ dna polymerase iii epsilon subunit HNS37_RS13480 ENOG4105EHG Permease protein HNS37_RS13485 ENOG4105E0A ABC, transporter HNS37_RS13535 ENOG4105CV1 Transketolase (EC 2.2.1.1) HNS37_RS13540 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HNS37_RS13545 ENOG4105BZA Phosphoglycerate kinase HNS37_RS13550 ENOG4105D2N Aldolase HNS37_RS13555 ENOG4105YB8 TM2 domain containing protein HNS37_RS13560 ENOG4105DUX Transporter HNS37_RS13565 ENOG4107UWN reductase HNS37_RS13575 ENOG4108V8F Transcriptional regulator, MarR family HNS37_RS13580 ENOG4105C94 Transporter HNS37_RS13595 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HNS37_RS13600 ENOG4105HMV Fimbrial protein HNS37_RS13605 ENOG4106PG1 outer membrane usher protein HNS37_RS13610 ENOG4108FZ9 Chaperone HNS37_RS13625 ENOG4108W9T type 1 fimbriae regulatory protein HNS37_RS13630 ENOG4105HMV Fimbrial protein HNS37_RS13635 ENOG4108ZJG MrfB protein HNS37_RS13640 ENOG4106PG1 outer membrane usher protein HNS37_RS13645 ENOG4106P2F Pfam:Pili_assembly_C HNS37_RS13660 ENOG4105H8W Fimbrial protein HNS37_RS13675 ENOG4105CFC Transporter HNS37_RS13680 ENOG4105VTS DnaJ-like, subfamily C HNS37_RS13690 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HNS37_RS13695 ENOG4105DFG type I secretion outer membrane protein HNS37_RS13700 ENOG4107QZV Type I secretion membrane fusion protein HNS37_RS13705 ENOG4108JJ6 Type I secretion system ATPase HNS37_RS13710 ENOG4105QNJ serralysin (EC 3.4.24.40) HNS37_RS13740 ENOG4107URF beta-phospho-glucomutase HNS37_RS13745 ENOG4105C71 hydrolase family 65, central catalytic HNS37_RS13750 ENOG4105C5Y PTS System HNS37_RS13755 ENOG4105D4X repressor HNS37_RS13790 ENOG4108JJA ABC, transporter HNS37_RS13800 ENOG4108WUH Transcriptional regulator, TetR family HNS37_RS13805 ENOG4105D5Q Arginine ornithine antiporter HNS37_RS13810 ENOG4105CXN decarboxylase HNS37_RS13835 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HNS37_RS13840 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HNS37_RS13845 ENOG4105CEN a g-specific adenine glycosylase HNS37_RS13855 ENOG41090ED Protein with unknown function (DUF469) HNS37_RS13860 ENOG4105CSV Glutaminase HNS37_RS13865 ENOG4105K33 Periplasmic Protein HNS37_RS13875 ENOG4105CSA Coproporphyrinogen iii oxidase HNS37_RS13880 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HNS37_RS13885 ENOG4108VIA integral membrane protein HNS37_RS13890 ENOG4105II7 pyrroline-5-carboxylate reductase HNS37_RS13895 ENOG4105DFA alanine racemase domain protein HNS37_RS13900 ENOG4105CZX twitching motility protein HNS37_RS13905 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HNS37_RS13910 ENOG4108UJU UPF0301 protein HNS37_RS13915 ENOG4105D7Z glutathione synthase HNS37_RS13920 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HNS37_RS13940 ENOG4105EJC lysr family transcriptional regulator HNS37_RS13945 ENOG4105RQF LysR family Transcriptional regulator HNS37_RS13955 ENOG4107QPN acyl-Coa dehydrogenase HNS37_RS13960 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HNS37_RS13965 ENOG4105E7A Glutamine amidotransferase HNS37_RS13970 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HNS37_RS13975 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HNS37_RS13980 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HNS37_RS13985 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HNS37_RS13990 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HNS37_RS13995 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HNS37_RS14000 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HNS37_RS14005 ENOG4105CJ2 (LipO)protein HNS37_RS14015 ENOG4105VDW Csbd family HNS37_RS14025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HNS37_RS14030 ENOG4105E0K tonB-dependent siderophore receptor HNS37_RS14035 ENOG4105CIN aminoacyl-histidine dipeptidase HNS37_RS14040 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HNS37_RS14045 ENOG4105V1F Fermentation respiration switch protein HNS37_RS14050 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HNS37_RS14055 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HNS37_RS14060 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HNS37_RS14065 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HNS37_RS14070 ENOG4105CEY Amp-dependent synthetase and ligase HNS37_RS14075 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HNS37_RS14080 ENOG4107TH8 cina domain protein HNS37_RS14085 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HNS37_RS14090 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HNS37_RS14095 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HNS37_RS14125 ENOG4105D9M gamma-glutamylcysteine synthetase HNS37_RS14130 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HNS37_RS14135 ENOG4108JU6 CBS domain protein HNS37_RS14140 ENOG4106KVJ cytochrome C assembly protein HNS37_RS14145 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HNS37_RS14150 ENOG4105K5M 30s ribosomal protein S16 HNS37_RS14160 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HNS37_RS14165 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HNS37_RS14170 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HNS37_RS14185 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HNS37_RS14190 ENOG4105CQC Prephenate dehydratase HNS37_RS14195 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HNS37_RS14200 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HNS37_RS14205 ENOG4105C34 Pseudouridine synthase HNS37_RS14210 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HNS37_RS14215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HNS37_RS14245 ENOG4105T42 (LipO)protein HNS37_RS14250 ENOG4105JIM Phosphatidylserine synthase HNS37_RS14255 ENOG4105CD5 CoA-binding domain protein HNS37_RS14260 ENOG4106IUH DTW domain containing protein HNS37_RS14265 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is HNS37_RS14270 ENOG4105EIB trna rrna methyltransferase HNS37_RS14275 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNS37_RS14280 ENOG4105CW7 secretion protein, HlyD family HNS37_RS14290 ENOG4105C6X Major Facilitator HNS37_RS14295 ENOG4108UAU isochorismatase HNS37_RS14300 ENOG4105NTK Transcriptional repressor Mpra HNS37_RS14305 ENOG4105EQ0 Major Facilitator superfamily HNS37_RS14310 ENOG4105X58 receptor HNS37_RS14315 ENOG4105GIJ Glycine betaine HNS37_RS14320 ENOG4108HQS Glycine betaine HNS37_RS14325 ENOG4108IJ7 Glycine betaine HNS37_RS14340 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HNS37_RS14350 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HNS37_RS14365 ENOG4107Z6W Protein CrcB homolog HNS37_RS14370 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HNS37_RS14375 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HNS37_RS14380 ENOG4108Z43 UPF0250 protein HNS37_RS14385 ENOG4105DZ1 carboxypeptidase HNS37_RS14390 ENOG4105K6T rare lipoprotein A HNS37_RS14395 ENOG4105CNI cell division protein FtsW HNS37_RS14400 ENOG4105CJN penicillin-binding protein HNS37_RS14405 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HNS37_RS14410 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HNS37_RS14425 ENOG4105DJF DNA polymerase III, delta' subunit HNS37_RS14430 ENOG4108U2H Rare lipoprotein B HNS37_RS14435 ENOG4105C8T Leucyl-tRNA synthetase HNS37_RS14440 ENOG4105CDA abc transporter atp-binding protein HNS37_RS14445 ENOG4105DRP amino acid AbC transporter HNS37_RS14450 ENOG4105EAD ABC transporter HNS37_RS14455 ENOG4107RP9 extracellular solute-binding protein, family 3 HNS37_RS14475 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HNS37_RS14485 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HNS37_RS14490 ENOG4108JU5 Magnesium and cobalt efflux protein HNS37_RS14495 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HNS37_RS14500 ENOG4105C9A Phoh family HNS37_RS14505 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HNS37_RS14510 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HNS37_RS14565 ENOG4105E2R ROK family HNS37_RS14570 ENOG4105CE4 GlcNAc 6-P deacetylase HNS37_RS14575 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HNS37_RS14580 ENOG4105CI1 PTS System HNS37_RS14585 ENOG4105CX6 glutaminyL-tRNA synthetase HNS37_RS14595 ENOG4105NX3 Membrane HNS37_RS14600 ENOG41090R7 Ferric uptake HNS37_RS14605 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HNS37_RS14610 ENOG4105NNH LexA regulated protein HNS37_RS14615 ENOG4105EV9 Alpha Beta Hydrolase HNS37_RS14620 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HNS37_RS14625 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HNS37_RS14630 ENOG4108W15 Protein of unknown function (DUF1456) HNS37_RS14645 ENOG4105XIQ Protein of unknown function (DUF2517) HNS37_RS14650 ENOG4107QNR UPF0135 protein HNS37_RS14660 ENOG4105DEG Vwa containing coxe family protein HNS37_RS14665 ENOG4105RD5 HNS37_RS14670 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HNS37_RS14680 ENOG4105C2C drug resistance transporter, Bcr CflA HNS37_RS14690 ENOG4105BZN citrate synthase HNS37_RS14695 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HNS37_RS14700 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HNS37_RS14710 ENOG4105E33 succinate dehydrogenase HNS37_RS14715 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HNS37_RS14720 ENOG4105C7S Dehydrogenase HNS37_RS14725 ENOG4105CMV Succinyl-CoA synthetase subunit beta HNS37_RS14730 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HNS37_RS14735 ENOG4105C4M (Ubiquinol oxidase) subunit I HNS37_RS14740 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HNS37_RS14750 ENOG4105KJB cyd operon protein YbgE HNS37_RS14755 ENOG4105HEI LysR family (Transcriptional regulator HNS37_RS14760 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNS37_RS14770 ENOG4107YD3 Thioesterase HNS37_RS14775 ENOG4105E02 MotA TolQ exbB proton channel HNS37_RS14785 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HNS37_RS14790 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HNS37_RS14795 ENOG4105KCK Peptidoglycan-associated lipoprotein HNS37_RS14800 ENOG4105UFD tol-pal system protein YbgF HNS37_RS14820 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HNS37_RS14825 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HNS37_RS14830 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HNS37_RS14835 ENOG4105DKW ABC transporter HNS37_RS14875 ENOG4105F4R Transcriptional regulator mode HNS37_RS14885 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HNS37_RS14890 ENOG4105E0C molybdate abc transporter HNS37_RS14895 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS14900 ENOG4108K4B hydrolase HNS37_RS14905 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HNS37_RS14910 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HNS37_RS14915 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HNS37_RS14920 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HNS37_RS14925 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HNS37_RS14935 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HNS37_RS14945 ENOG4105CHW UPF0052 protein HNS37_RS14950 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HNS37_RS14955 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HNS37_RS14960 ENOG4105M00 molybdopterin converting factor, subunit 1 HNS37_RS14965 ENOG4108ZAF Molybdopterin HNS37_RS14970 ENOG4105HFZ Membrane HNS37_RS14985 ENOG4107QWP ABC-2 type transporter HNS37_RS14990 ENOG4107QWP ABC-2 type transporter HNS37_RS14995 ENOG4105CJ1 ABC, transporter HNS37_RS15005 ENOG4107MVR Transcriptional regulator HNS37_RS15010 ENOG4105C1J atp-dependent rna helicase HNS37_RS15015 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HNS37_RS15025 ENOG4105KHC sulfurtransferase HNS37_RS15035 ENOG4105CEE C4-dicarboxylate transporter HNS37_RS15045 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HNS37_RS15050 ENOG4108PGP mmge prpd family protein HNS37_RS15055 ENOG4107NQ8 LysR family Transcriptional regulator HNS37_RS15060 ENOG4105DVT helicase HNS37_RS15065 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HNS37_RS15075 ENOG4108URH decarboxylase HNS37_RS15090 ENOG4105D06 uba thif-type nad fad binding protein HNS37_RS15095 ENOG4105CVM Molybdenum cofactor synthesis domain protein HNS37_RS15100 ENOG4105CBP Major Facilitator HNS37_RS15105 ENOG4105EUJ GTP cyclohydrolase i HNS37_RS15110 ENOG4105DHF Membrane HNS37_RS15115 ENOG4107GZ4 SanA protein HNS37_RS15120 ENOG4107R1I NAD-dependent malic enzyme HNS37_RS15125 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HNS37_RS15130 ENOG41067MG lrgb family HNS37_RS15135 ENOG4105VAW lrga family HNS37_RS15140 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HNS37_RS15145 ENOG4105D1F ATP-binding protein HNS37_RS15150 ENOG4105DBI uridine monophosphokinase HNS37_RS15155 ENOG4105DHP deoxycytidine triphosphate deaminase HNS37_RS15160 ENOG4108GAE asmA family HNS37_RS15165 ENOG4105CEE C4-dicarboxylate transporter HNS37_RS15170 ENOG4105EE5 Membrane protein terC HNS37_RS15175 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HNS37_RS15180 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HNS37_RS15185 ENOG4105C0A alcohol dehydrogenase HNS37_RS15190 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HNS37_RS15195 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HNS37_RS15200 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HNS37_RS15205 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HNS37_RS15210 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HNS37_RS15220 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HNS37_RS15225 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HNS37_RS15230 ENOG4107SRH Nad-dependent epimerase dehydratase HNS37_RS15235 ENOG4108TGY Glutathione S-transferase HNS37_RS15240 ENOG4105DZ1 carboxypeptidase HNS37_RS15245 ENOG4105CKU formyltetrahydrofolate synthetase HNS37_RS15250 ENOG4105EJQ L-serine dehydratase HNS37_RS15255 ENOG4105C44 Serine transporter HNS37_RS15260 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HNS37_RS15265 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HNS37_RS15270 ENOG41090BQ Glutaredoxin HNS37_RS15275 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HNS37_RS15280 ENOG4108RMJ sensory transduction regulator HNS37_RS15285 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HNS37_RS15290 ENOG4105DMR ABC, transporter HNS37_RS15295 ENOG4105GBT ABC transporter HNS37_RS15300 ENOG4106PMH Extracellular solute-binding protein family 3 HNS37_RS15305 ENOG4105E5Z arginine transporter ATP-binding subunit HNS37_RS15310 ENOG4105CGD Nad-dependent epimerase dehydratase HNS37_RS15315 ENOG4105DWU Membrane HNS37_RS15320 ENOG4105CPB ATP-dependent endonuclease of the OLD family HNS37_RS15325 ENOG4105DJY efflux transporter, rnd family, mfp subunit HNS37_RS15330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HNS37_RS15335 ENOG4105VEQ Cold shock protein HNS37_RS15340 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HNS37_RS15345 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HNS37_RS15355 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HNS37_RS15360 ENOG4108JJ8 (ABC) transporter HNS37_RS15365 ENOG4108JJ9 ABC, transporter HNS37_RS15370 ENOG4105C3M thioredoxin reductase HNS37_RS15375 ENOG4105EW9 transcriptional regulator AsnC family HNS37_RS15380 ENOG4105CNU cell division protein FtsK HNS37_RS15385 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HNS37_RS15390 ENOG4105D1H recombination factor protein RarA HNS37_RS15395 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HNS37_RS15405 ENOG4105DG4 malate L-lactate dehydrogenase HNS37_RS15415 ENOG4105F1A Pyruvate formate-lyase HNS37_RS15420 ENOG4105C6N Formate acetyltransferase HNS37_RS15425 ENOG4105TMB Formate nitrite transporter HNS37_RS15430 ENOG4105DDY UPF0142 protein ycaO HNS37_RS15435 ENOG4105HDK L-asparaginase HNS37_RS15450 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HNS37_RS15455 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HNS37_RS15460 ENOG4105CAT Cytidine monophosphate kinase HNS37_RS15465 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HNS37_RS15470 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HNS37_RS15475 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HNS37_RS15480 ENOG4105BZ1 (ABC) transporter HNS37_RS15485 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HNS37_RS15495 ENOG4105W49 UPF0434 protein HNS37_RS15500 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HNS37_RS15505 ENOG4107S90 membrAne HNS37_RS15510 ENOG4106371 Methyltransferase HNS37_RS15515 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HNS37_RS15520 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HNS37_RS15525 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HNS37_RS15530 ENOG4108UY2 Chloramphenicol acetyltransferase HNS37_RS15535 ENOG4105F0S class B acid phosphatase HNS37_RS15540 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HNS37_RS15545 ENOG4105EAQ (twin-arginine translocation) pathway signal HNS37_RS15550 ENOG4105C5X domain protein HNS37_RS15555 ENOG4105GMB type VI secretion system effector, hcp1 family HNS37_RS15590 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HNS37_RS15640 ENOG4108WC9 type VI secretion system effector, hcp1 family HNS37_RS15645 ENOG4105CS6 Rhs element vgr protein HNS37_RS15670 ENOG4105CNA YD repeat protein HNS37_RS15785 ENOG4105CGF Aromatic amino acid aminotransferase HNS37_RS15790 ENOG4105FCK Membrane HNS37_RS15795 ENOG4105C5S asparaginyl-tRNA synthetase HNS37_RS15805 ENOG4107RH7 Nicotinate phosphoribosyltransferase HNS37_RS15810 ENOG4105CD8 aminopeptidase N HNS37_RS15815 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HNS37_RS15820 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HNS37_RS15825 ENOG4105QVC MOSC domain-containing protein HNS37_RS15830 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HNS37_RS15835 ENOG4105C5H ABC transporter HNS37_RS15840 ENOG4105F1S paraquat-inducible protein a HNS37_RS15845 ENOG4105DY2 Paraquat-inducible protein b HNS37_RS15850 ENOG4108Q2G (LipO)protein HNS37_RS15860 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HNS37_RS15865 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HNS37_RS15870 ENOG4105DAN ATP-dependent protease HNS37_RS15875 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HNS37_RS15895 ENOG4105EM2 membrane HNS37_RS15900 ENOG41088T4 Helicase IV HNS37_RS15905 ENOG4108Z5K methylglyoxal synthase HNS37_RS15910 ENOG4105K4P CoA-binding domain protein HNS37_RS15915 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HNS37_RS15920 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HNS37_RS15925 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HNS37_RS15945 ENOG4108YS1 cytoplasmic protein HNS37_RS15955 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HNS37_RS15960 ENOG4105HEI LysR family (Transcriptional regulator HNS37_RS15965 ENOG4105CV8 reductase HNS37_RS15975 ENOG4105UEI Transcriptional Regulator AraC Family HNS37_RS15995 ENOG4105D1S lipid A biosynthesis HNS37_RS16020 ENOG4105DTA methyltransferase HNS37_RS16120 ENOG4105CAR Terminase, large subunit HNS37_RS16125 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HNS37_RS16130 ENOG4105CDU Replicative dna helicase HNS37_RS16175 ENOG4105KUS lysozyme HNS37_RS16210 ENOG4108C66 Inherit from COG: DNA primase HNS37_RS16315 ENOG4107XU6 Glycosyl transferase (Group 1 HNS37_RS16330 ENOG4105E68 Sulfatase HNS37_RS16335 ENOG4105PAN UPF0352 protein HNS37_RS16340 ENOG4106V8H Nucleoid-associated protein HNS37_RS16345 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HNS37_RS16350 ENOG4105CFI type iii restriction protein res subunit HNS37_RS16355 ENOG4105I08 Pseudouridine synthase HNS37_RS16360 ENOG4105C2C drug resistance transporter, Bcr CflA HNS37_RS16370 ENOG4107TT5 NLP P60 protein HNS37_RS16375 ENOG41076MN Phosphoesterase, PA-phosphatase related HNS37_RS16390 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HNS37_RS16405 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HNS37_RS16410 ENOG4105HMI Membrane HNS37_RS16415 ENOG4105DUM transcriptional regulator, lysR family HNS37_RS16420 ENOG4108IQI permease HNS37_RS16425 ENOG4105D05 Receptor HNS37_RS16430 ENOG4105CUB amino acid HNS37_RS16440 ENOG4107RA9 decarboxylase HNS37_RS16445 ENOG4105C5Q Transcriptional regulator HNS37_RS16450 ENOG4105CXG d-lactate dehydrogenase HNS37_RS16455 ENOG4105CJB Exodeoxyribonuclease I HNS37_RS16460 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HNS37_RS16465 ENOG41090HJ UPF0265 protein HNS37_RS16470 ENOG4107QQB Ribonuclease E HNS37_RS16475 ENOG4105EI2 Pseudouridine synthase HNS37_RS16485 ENOG4108UHJ MAF-like protein HNS37_RS16490 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HNS37_RS16495 ENOG4105VGS 50s ribosomal protein l32 HNS37_RS16500 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HNS37_RS16505 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HNS37_RS16510 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HNS37_RS16515 ENOG4105CHR reductase HNS37_RS16520 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HNS37_RS16525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HNS37_RS16530 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HNS37_RS16535 ENOG4105HHA aminodeoxychorismate lyase HNS37_RS16540 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HNS37_RS16545 ENOG4107QRG dna polymerase iii HNS37_RS16550 ENOG4105F8V Hydrolase, tatD family HNS37_RS16555 ENOG4105K59 histidine triad (HIT) protein HNS37_RS16560 ENOG41090DQ Lipoprotein HNS37_RS16565 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HNS37_RS16570 ENOG4108KN0 Choline kinase HNS37_RS16575 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HNS37_RS16580 ENOG4105D0Y UPF0227 protein HNS37_RS16585 ENOG4105CEP NADH dehydrogenase HNS37_RS16590 ENOG4107MBR 17 kDa surface antigen HNS37_RS16595 ENOG4108JA2 transcriptioN-repair coupling factor HNS37_RS16600 ENOG4105D60 lipoprotein releasing system transmembrane protein HNS37_RS16610 ENOG4105D60 lipoprotein releasing system transmembrane protein HNS37_RS16625 ENOG4105EZE Cupin 4 family protein HNS37_RS16630 ENOG4105IFJ Histidine kinase HNS37_RS16635 ENOG4105XJC Two component transcriptional regulator (Winged helix family HNS37_RS16640 ENOG4107QTF adenylosuccinate lyase HNS37_RS16645 ENOG41075W9 High frequency lysogenization protein HflD homolog HNS37_RS16650 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HNS37_RS16660 ENOG4108R99 pseudouridine synthase HNS37_RS16665 ENOG4108HMX isocitrate dehydrogenase (NADP) HNS37_RS16670 ENOG4108I1J Integrase HNS37_RS16680 ENOG4108R7K Metal Dependent Phosphohydrolase HNS37_RS16695 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HNS37_RS16735 ENOG4108MXB Protein of unknown function (DUF968) HNS37_RS16740 ENOG4105HRS Antitermination protein HNS37_RS16745 ENOG4105VEQ Cold shock protein HNS37_RS16750 ENOG4108ZNX Heat shock protein HNS37_RS16775 ENOG4105KUS lysozyme HNS37_RS16810 ENOG4105CAR Terminase, large subunit HNS37_RS16915 ENOG4108HMX isocitrate dehydrogenase (NADP) HNS37_RS16965 ENOG4105VEQ Cold shock protein HNS37_RS16970 ENOG4108ZNX Heat shock protein HNS37_RS16980 ENOG4105KVH Transcriptional regulator HNS37_RS16985 ENOG4105ECR NmrA family HNS37_RS16995 ENOG4105DBI uridine monophosphokinase HNS37_RS17005 ENOG4105GTN ParB Domain Protein Nuclease HNS37_RS17010 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HNS37_RS17015 ENOG4108WF3 methyltransferase HNS37_RS17030 ENOG4107SEY Conserved Protein HNS37_RS17040 ENOG4105Z2P Protein of unknown function (DUF465) HNS37_RS17070 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HNS37_RS17075 ENOG4105HRS Antitermination protein HNS37_RS17085 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HNS37_RS17090 ENOG4107SSZ Phosphatase HNS37_RS17105 ENOG4108RW8 Universal stress protein F HNS37_RS17110 ENOG41090A1 ferritin HNS37_RS17115 ENOG4105FXM Copper resistance protein HNS37_RS17120 ENOG4108PNC copper resistance HNS37_RS17125 ENOG4105NKT exported protein HNS37_RS17135 ENOG4105DY2 Paraquat-inducible protein b HNS37_RS17140 ENOG4105H2K paraquat-inducible protein a HNS37_RS17145 ENOG4108ZGC gaf domain protein HNS37_RS17150 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HNS37_RS17155 ENOG4105CN1 protease HNS37_RS17165 ENOG4105D0M Protease HtpX homolog HNS37_RS17170 ENOG4108ETY sodium dicarboxylate symporter HNS37_RS17175 ENOG4107K5X Membrane-bound metal-dependent hydrolase HNS37_RS17180 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HNS37_RS17185 ENOG4107PN8 YfeABCD locus regulator HNS37_RS17195 ENOG4105CC5 ABC transporter HNS37_RS17200 ENOG4105CC5 ABC transporter HNS37_RS17205 ENOG4105DIK (ABC) transporter HNS37_RS17210 ENOG4105DSE periplasmic solute binding protein HNS37_RS17230 ENOG4108Z7R Chaperone CsaA HNS37_RS17245 ENOG4105C22 threonyL-tRNA synthetase HNS37_RS17250 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HNS37_RS17255 ENOG41082NX 50s ribosomal protein l35 HNS37_RS17260 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HNS37_RS17270 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HNS37_RS17275 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HNS37_RS17280 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HNS37_RS17285 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HNS37_RS17290 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HNS37_RS17295 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HNS37_RS17300 ENOG4105CKK Glycosyl transferase, family 2 HNS37_RS17305 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HNS37_RS17310 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HNS37_RS17315 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HNS37_RS17320 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HNS37_RS17325 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HNS37_RS17330 ENOG4108QBX (LipO)protein HNS37_RS17335 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HNS37_RS17345 ENOG4105D5U fad dependent oxidoreductase HNS37_RS17350 ENOG4107YCY Transcriptional regulator HNS37_RS17365 ENOG4107ZTW SNARE associated Golgi HNS37_RS17370 ENOG4105C7K acetolactate synthase HNS37_RS17420 ENOG4105C3G gtp-binding protein HNS37_RS17425 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HNS37_RS17430 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HNS37_RS17435 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HNS37_RS17440 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HNS37_RS17445 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HNS37_RS17450 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HNS37_RS17455 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HNS37_RS17460 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HNS37_RS17465 ENOG41063JG Transcriptional regulator HNS37_RS17470 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HNS37_RS17475 ENOG4105N5T Radical SAM Protein HNS37_RS17485 ENOG4105CHH sulfate transporter HNS37_RS17495 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HNS37_RS17510 ENOG4107XHZ cytoplasmic chaperone TorD family protein HNS37_RS17520 ENOG4105EV4 Multidrug resistance protein mdtH HNS37_RS17525 ENOG4105D9U N-acetyltransferase HNS37_RS17530 ENOG4105CJR Integral membrane protein (MviN HNS37_RS17540 ENOG4105C75 arginyL-tRNA synthetase HNS37_RS17545 ENOG4106ZCM YecM protein HNS37_RS17550 ENOG4106N3A copper homeostasis protein cutc HNS37_RS17560 ENOG4105C5H ABC transporter HNS37_RS17565 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HNS37_RS17570 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HNS37_RS17575 ENOG4105WJG Glutathione HNS37_RS17580 ENOG4105C9M aspartyl-trna synthetase HNS37_RS17585 ENOG4108TIT dATP pyrophosphohydrolase HNS37_RS17590 ENOG4105CDY transcriptional regulatory protein HNS37_RS17595 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HNS37_RS17600 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HNS37_RS17605 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HNS37_RS17610 ENOG4105FAV ABC, transporter HNS37_RS17615 ENOG4105FDK ABC transporter HNS37_RS17620 ENOG4105NXV High-affinity zinc uptake system protein HNS37_RS17625 ENOG4105DR5 peptidase HNS37_RS17630 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HNS37_RS17635 ENOG4105CA9 Pyruvate kinase HNS37_RS17640 ENOG4106KNT transcriptional regulator HNS37_RS17645 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HNS37_RS17650 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HNS37_RS17655 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HNS37_RS17660 ENOG4105CGD Nad-dependent epimerase dehydratase HNS37_RS17665 ENOG4105M4H endoribonuclease L-psp HNS37_RS17670 ENOG4105DVT helicase HNS37_RS17675 ENOG41072GX Peptidase M22 Glycoprotease HNS37_RS17680 ENOG4105Y4Z Outer Membrane Lipoprotein HNS37_RS17685 ENOG4105CEY Amp-dependent synthetase and ligase HNS37_RS17690 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HNS37_RS17695 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HNS37_RS17700 ENOG4107QMS site-determining protein HNS37_RS17705 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HNS37_RS17710 ENOG4105VNG YcgL domain-containing protein HNS37_RS17715 ENOG4105CVE Lytic murein transglycosylase HNS37_RS17720 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HNS37_RS17725 ENOG4108ZZ3 UPF0260 protein HNS37_RS17730 ENOG4105C4B ABC transporter, permease HNS37_RS17735 ENOG41083J0 (ABC) transporter HNS37_RS17745 ENOG4105UEI Transcriptional Regulator AraC Family HNS37_RS17755 ENOG4105C8Q Methyl-accepting chemotaxis HNS37_RS17760 ENOG4105C5I Dehydrogenase HNS37_RS17765 ENOG4107H52 Dicarboxylate transport HNS37_RS17770 ENOG410689M (LipO)protein HNS37_RS17775 ENOG4105WXT Conserved Protein HNS37_RS17790 ENOG4105CW0 outer membrane usher protein HNS37_RS17805 ENOG4105DQ6 Transposase HNS37_RS17830 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HNS37_RS17835 ENOG4105CQ7 ATP-dependent helicase HNS37_RS17850 ENOG4105CW0 outer membrane usher protein HNS37_RS17855 ENOG4108VCD Chaperone HNS37_RS17865 ENOG4105D5Q Arginine ornithine antiporter HNS37_RS17870 ENOG4105C5D exported protein HNS37_RS17875 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HNS37_RS17880 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HNS37_RS17885 ENOG4105Q9Y Universal stress protein HNS37_RS17890 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HNS37_RS17895 ENOG4107QY8 reductase HNS37_RS17900 ENOG4105QAX Iron-sulfur HNS37_RS17925 ENOG4105NTW Transcriptional regulator HNS37_RS17940 ENOG4105D3R alkyl hydroperoxide reductase HNS37_RS17945 ENOG4108JU3 Alkyl hydroperoxide reductase HNS37_RS17990 ENOG4105FYV Amp nucleosidase HNS37_RS17995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNS37_RS18000 ENOG4105D44 asparaginase HNS37_RS18005 ENOG4105D0S secretion protein (HlyD HNS37_RS18010 ENOG4105CJ1 ABC, transporter HNS37_RS18015 ENOG4105CMI transporter HNS37_RS18020 ENOG4105EEX Two component transcriptional regulator (Winged helix family HNS37_RS18025 ENOG4105C08 Histidine kinase HNS37_RS18030 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HNS37_RS18035 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HNS37_RS18040 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HNS37_RS18045 ENOG4107SNB ankyrin repeat protein YahD HNS37_RS18050 ENOG4107Y2X deaminase HNS37_RS18055 ENOG4108NEM leader-binding protein dmsD HNS37_RS18060 ENOG4107KGK dmso reductase anchor subunit HNS37_RS18065 ENOG4105QAX Iron-sulfur HNS37_RS18070 ENOG4107QY8 reductase HNS37_RS18075 ENOG4105E98 transcriptional regulator DeoR family HNS37_RS18095 ENOG4105CMT Dihydroxyacetone kinase HNS37_RS18105 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HNS37_RS18115 ENOG4105KME endoribonuclease L-psp