locus-tag	class	description
HNS37_RS00020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HNS37_RS00025	COG2169	Transcriptional regulator
HNS37_RS00025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HNS37_RS00040	COG1181	Belongs to the D-alanine--D-alanine ligase family
HNS37_RS00060	COG1464	Belongs to the NlpA lipoprotein family
HNS37_RS00070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNS37_RS00080	COG2814	Major facilitator Superfamily
HNS37_RS00090	COG0583	DNA-binding transcription factor activity
HNS37_RS00100	COG1309	transcriptional regulator
HNS37_RS00110	COG0488	(ABC) transporter
HNS37_RS00115	COG1671	Belongs to the UPF0178 family
HNS37_RS00120	COG0402	S-adenosylhomocysteine deaminase activity
HNS37_RS00130	COG2814	Major facilitator Superfamily
HNS37_RS00140	COG0477	Major facilitator Superfamily
HNS37_RS00145	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HNS37_RS00160	COG1289	transmembrane transporter activity
HNS37_RS00165	COG1538	Outer membrane efflux protein
HNS37_RS00185	COG0583	DNA-binding transcription factor activity
HNS37_RS00190	COG0443	Heat shock 70 kDa protein
HNS37_RS00205	COG1280	lysine exporter protein (LysE YggA)
HNS37_RS00210	COG1070	Carbohydrate kinase
HNS37_RS00215	COG2115	Belongs to the xylose isomerase family
HNS37_RS00230	COG4628	conserved protein (DUF2132)
HNS37_RS00270	COG4221	oxidoreductase activity
HNS37_RS00285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HNS37_RS00290	COG1940	carbohydrate kinase activity
HNS37_RS00295	COG0583	DNA-binding transcription factor activity
HNS37_RS00300	COG2814	Major facilitator Superfamily
HNS37_RS00310	COG0114	fumarate hydratase activity
HNS37_RS00315	COG5339	Protein conserved in bacteria
HNS37_RS00325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HNS37_RS00330	COG0385	Bile acid
HNS37_RS00335	COG0673	inositol 2-dehydrogenase activity
HNS37_RS00345	COG4657	Part of a membrane complex involved in electron transport
HNS37_RS00355	COG4656	Part of a membrane complex involved in electron transport
HNS37_RS00365	COG4659	FMN binding
HNS37_RS00375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HNS37_RS00380	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HNS37_RS00385	COG0023	Translation Initiation Factor
HNS37_RS00390	COG0284	orotidine-5'-phosphate decarboxylase activity
HNS37_RS00395	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HNS37_RS00400	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HNS37_RS00405	COG0671	phosphoesterase, PA-phosphatase related
HNS37_RS00410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HNS37_RS00415	COG1464	Belongs to the NlpA lipoprotein family
HNS37_RS00420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HNS37_RS00430	COG0583	DNA-binding transcription factor activity
HNS37_RS00455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HNS37_RS00465	COG0616	signal peptide processing
HNS37_RS00470	COG1028	Short-chain dehydrogenase reductase Sdr
HNS37_RS00485	COG1187	pseudouridine synthase activity
HNS37_RS00490	COG0009	L-threonylcarbamoyladenylate synthase
HNS37_RS00500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HNS37_RS00505	COG0512	Glutamine amidotransferase of anthranilate synthase
HNS37_RS00510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HNS37_RS00520	COG0133	tryptophan synthase activity
HNS37_RS00525	COG0159	tryptophan synthase activity
HNS37_RS00535	COG3047	cAMP biosynthetic process
HNS37_RS00550	COG2917	probably involved in intracellular septation
HNS37_RS00570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HNS37_RS00585	COG0346	lactoylglutathione lyase activity
HNS37_RS00605	COG0598	Magnesium transport protein CorA
HNS37_RS00620	COG4166	transmembrane transport
HNS37_RS00625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HNS37_RS00640	COG3768	UPF0283 membrane protein
HNS37_RS00645	COG3106	COG3106 Predicted ATPase
HNS37_RS00655	COG1983	PspC domain protein
HNS37_RS00665	COG1842	Phage shock protein A
HNS37_RS00670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HNS37_RS00675	COG4166	transmembrane transport
HNS37_RS00685	COG4171	peptide transport system, permease
HNS37_RS00690	COG4172	Belongs to the ABC transporter superfamily
HNS37_RS00700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HNS37_RS00715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HNS37_RS00720	COG0259	pyridoxamine-phosphate oxidase activity
HNS37_RS00725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HNS37_RS00740	COG3313	Fe-S protein
HNS37_RS00745	COG0346	lactoylglutathione lyase activity
HNS37_RS00750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HNS37_RS00755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HNS37_RS00760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HNS37_RS00775	COG0730	response to heat
HNS37_RS00790	COG1609	Transcriptional regulator
HNS37_RS00795	COG0583	DNA-binding transcription factor activity
HNS37_RS00800	COG2814	Major facilitator Superfamily
HNS37_RS00805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HNS37_RS00810	COG0307	riboflavin synthase, alpha
HNS37_RS00815	COG0534	Mate efflux family protein
HNS37_RS00835	COG0531	amino acid
HNS37_RS00840	COG0076	glutamate decarboxylase activity
HNS37_RS00860	COG1376	ErfK ybiS ycfS ynhG family protein
HNS37_RS00860	COG1388	LysM domain
HNS37_RS00865	COG2166	iron-sulfur cluster assembly
HNS37_RS00870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HNS37_RS00875	COG0719	Fe-S assembly protein
HNS37_RS00880	COG0396	ATPase activity
HNS37_RS00885	COG0719	Fe-S assembly protein
HNS37_RS00890	COG0316	Belongs to the HesB IscA family
HNS37_RS00900	COG2050	protein possibly involved in aromatic compounds catabolism
HNS37_RS00905	COG0247	lactate metabolic process
HNS37_RS00905	COG0277	FAD linked oxidase domain protein
HNS37_RS00910	COG0628	permease
HNS37_RS00915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HNS37_RS00915	COG0574	Belongs to the PEP-utilizing enzyme family
HNS37_RS00920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HNS37_RS00925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HNS37_RS00940	COG4771	TonB-dependent receptor
HNS37_RS00945	COG3720	iron ion transport
HNS37_RS00950	COG4558	Periplasmic binding protein
HNS37_RS00955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HNS37_RS00960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HNS37_RS00970	COG1280	lysine exporter protein (LysE YggA)
HNS37_RS00975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HNS37_RS00980	COG1271	oxidase subunit
HNS37_RS00985	COG1294	oxidase, subunit
HNS37_RS01000	COG3152	Membrane
HNS37_RS01005	COG1702	phosphate starvation-inducible protein PhoH
HNS37_RS01015	COG2356	endonuclease I
HNS37_RS01025	COG3610	response to peptide
HNS37_RS01030	COG2966	Psort location CytoplasmicMembrane, score
HNS37_RS01040	COG0589	response to stress
HNS37_RS01050	COG0589	response to stress
HNS37_RS01070	COG0113	porphobilinogen synthase activity
HNS37_RS01080	COG0402	S-adenosylhomocysteine deaminase activity
HNS37_RS01085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HNS37_RS01090	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HNS37_RS01095	COG1012	belongs to the aldehyde dehydrogenase family
HNS37_RS01100	COG1309	transcriptional regulator
HNS37_RS01105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HNS37_RS01110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNS37_RS01125	COG3188	usher protein
HNS37_RS01135	COG3539	Fimbrial protein
HNS37_RS01145	COG1396	sequence-specific DNA binding
HNS37_RS01155	COG0444	Belongs to the ABC transporter superfamily
HNS37_RS01160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HNS37_RS01190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNS37_RS01195	COG4166	transmembrane transport
HNS37_RS01200	COG0601	transmembrane transport
HNS37_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HNS37_RS01215	COG4608	Belongs to the ABC transporter superfamily
HNS37_RS01220	COG2095	MarC family integral membrane protein
HNS37_RS01225	COG1012	belongs to the aldehyde dehydrogenase family
HNS37_RS01225	COG1454	alcohol dehydrogenase
HNS37_RS01230	COG1435	thymidine kinase activity
HNS37_RS01245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HNS37_RS01250	COG0745	RESPONSE REGULATOR receiver
HNS37_RS01255	COG3012	SEC-C Motif Domain Protein
HNS37_RS01260	COG0788	formyltetrahydrofolate deformylase activity
HNS37_RS01270	COG0583	DNA-binding transcription factor activity
HNS37_RS01275	COG0708	Exodeoxyribonuclease III
HNS37_RS01280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HNS37_RS01285	COG0709	Synthesizes selenophosphate from selenide and ATP
HNS37_RS01290	COG0778	Nitroreductase
HNS37_RS01295	COG0616	signal peptide processing
HNS37_RS01300	COG0252	asparaginase activity
HNS37_RS01305	COG1335	isochorismatase
HNS37_RS01320	COG3139	Protein of unknown function (DUF1315)
HNS37_RS01335	COG0676	glucose-6-phosphate 1-epimerase activity
HNS37_RS01340	COG3713	MltA-interacting MipA family protein
HNS37_RS01345	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HNS37_RS01350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HNS37_RS01355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNS37_RS01360	COG2186	Transcriptional regulator
HNS37_RS01365	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HNS37_RS01370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HNS37_RS01380	COG2076	Multidrug Resistance protein
HNS37_RS01430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HNS37_RS01435	COG0322	excinuclease ABC activity
HNS37_RS01440	COG2197	response regulator
HNS37_RS01445	COG0778	Nitroreductase
HNS37_RS01450	COG1494	fructose-1,6-bisphosphatase
HNS37_RS01455	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HNS37_RS01515	COG3842	ATPase activity
HNS37_RS01520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HNS37_RS01525	COG0725	ABC transporter, periplasmic molybdate-binding protein
HNS37_RS01530	COG2390	Transcriptional regulator
HNS37_RS01535	COG1324	tolerance protein
HNS37_RS01555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HNS37_RS01555	COG0519	Catalyzes the synthesis of GMP from XMP
HNS37_RS01560	COG0517	IMP dehydrogenase activity
HNS37_RS01560	COG0516	GMP reductase activity
HNS37_RS01565	COG1570	exodeoxyribonuclease VII activity
HNS37_RS01570	COG1629	transport
HNS37_RS01570	COG4206	TonB-dependent receptor
HNS37_RS01575	COG1770	oligopeptidase
HNS37_RS01590	COG0280	phosphate acetyltransferase
HNS37_RS01590	COG0281	malic enzyme
HNS37_RS01595	COG2197	response regulator
HNS37_RS01605	COG1393	Belongs to the ArsC family
HNS37_RS01610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HNS37_RS01615	COG1876	peptidase activity
HNS37_RS01620	COG2832	Protein of unknown function (DUF454)
HNS37_RS01630	COG1444	tRNA N-acetyltransferase activity
HNS37_RS01635	COG2707	UPF0756 membrane protein
HNS37_RS01640	COG2321	neutral zinc metallopeptidase
HNS37_RS01645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HNS37_RS01650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HNS37_RS01655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HNS37_RS01660	COG2716	regulation of RNA biosynthetic process
HNS37_RS01665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HNS37_RS01670	COG0628	permease
HNS37_RS01675	COG4783	chaperone-mediated protein folding
HNS37_RS01680	COG1393	Belongs to the ArsC family
HNS37_RS01685	COG2211	Major facilitator Superfamily
HNS37_RS01690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HNS37_RS01695	COG0668	transmembrane transport
HNS37_RS01700	COG2233	PERMEase
HNS37_RS01705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HNS37_RS01710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HNS37_RS01715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HNS37_RS01720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNS37_RS01725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HNS37_RS01735	COG2239	Acts as a magnesium transporter
HNS37_RS01750	COG3104	oligopeptide transport
HNS37_RS01755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNS37_RS01760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNS37_RS01765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNS37_RS01770	COG2205	protein histidine kinase activity
HNS37_RS01775	COG0745	RESPONSE REGULATOR receiver
HNS37_RS01785	COG1597	lipid kinase activity
HNS37_RS01790	COG1830	Aldolase
HNS37_RS01810	COG1113	amino acid transport
HNS37_RS01825	COG0561	phosphatase activity
HNS37_RS01830	COG1114	Component of the transport system for branched-chain amino acids
HNS37_RS01835	COG3023	N-Acetylmuramoyl-L-alanine amidase
HNS37_RS01840	COG1115	amino acid carrier protein
HNS37_RS01855	COG3140	Belongs to the UPF0181 family
HNS37_RS01865	COG0494	nUDIX hydrolase
HNS37_RS01870	COG1760	l-serine dehydratase
HNS37_RS01875	COG1971	Probably functions as a manganese efflux pump
HNS37_RS01880	COG2226	methyltransferase
HNS37_RS01890	COG0589	response to stress
HNS37_RS01900	COG0589	response to stress
HNS37_RS01905	COG1113	amino acid transport
HNS37_RS01915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNS37_RS01920	COG0506	proline dehydrogenase activity
HNS37_RS01920	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HNS37_RS01920	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HNS37_RS01930	COG1191	sigma factor activity
HNS37_RS01980	COG1677	Flagellar hook-basal body complex protein FliE
HNS37_RS01985	COG1766	The M ring may be actively involved in energy transduction
HNS37_RS02000	COG1157	protein secretion by the type III secretion system
HNS37_RS02005	COG2882	bacterial-type flagellum organization
HNS37_RS02015	COG1580	Controls the rotational direction of flagella during chemotaxis
HNS37_RS02035	COG1338	Plays a role in the flagellum-specific transport system
HNS37_RS02040	COG1987	bacterial-type flagellum assembly
HNS37_RS02055	COG1256	bacterial-type flagellum assembly
HNS37_RS02065	COG1706	bacterial-type flagellum-dependent cell motility
HNS37_RS02070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HNS37_RS02095	COG1558	bacterial-type flagellum-dependent cell motility
HNS37_RS02100	COG1815	bacterial-type flagellum-dependent cell motility
HNS37_RS02130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HNS37_RS02140	COG0745	RESPONSE REGULATOR receiver
HNS37_RS02145	COG2201	protein-glutamate methylesterase activity
HNS37_RS02155	COG0840	transmembrane signaling receptor activity
HNS37_RS02160	COG0840	transmembrane signaling receptor activity
HNS37_RS02165	COG0835	chemotaxis
HNS37_RS02170	COG2198	Histidine kinase
HNS37_RS02170	COG0643	Histidine kinase
HNS37_RS02175	COG1360	Flagellar Motor Protein
HNS37_RS02195	COG1285	pathogenesis
HNS37_RS02235	COG0418	dihydroorotase activity
HNS37_RS02275	COG1560	Kdo2-lipid A biosynthetic process
HNS37_RS02280	COG2814	Major facilitator Superfamily
HNS37_RS02285	COG3104	oligopeptide transport
HNS37_RS02295	COG1607	acyl-coa hydrolase
HNS37_RS02310	COG1902	pentaerythritol trinitrate reductase activity
HNS37_RS02335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HNS37_RS02340	COG1396	sequence-specific DNA binding
HNS37_RS02350	COG3247	response to pH
HNS37_RS02355	COG0668	transmembrane transport
HNS37_RS02360	COG0243	molybdopterin cofactor binding
HNS37_RS02365	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS02370	COG3302	dmso reductase anchor subunit
HNS37_RS02500	COG2198	Histidine kinase
HNS37_RS02500	COG0642	Histidine kinase
HNS37_RS02505	COG2197	response regulator
HNS37_RS02510	COG0784	Response regulator, receiver
HNS37_RS02510	COG2205	protein histidine kinase activity
HNS37_RS02520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HNS37_RS02525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNS37_RS02530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNS37_RS02535	COG0633	Ferredoxin
HNS37_RS02545	COG0814	amino acid
HNS37_RS02575	COG1441	menaquinone biosynthetic process
HNS37_RS02580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HNS37_RS02585	COG0596	Alpha beta hydrolase
HNS37_RS02590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HNS37_RS02595	COG1169	isochorismate synthase
HNS37_RS02610	COG1007	ATP synthesis coupled electron transport
HNS37_RS02615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNS37_RS02620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HNS37_RS02625	COG0713	ATP synthesis coupled electron transport
HNS37_RS02630	COG0839	Belongs to the complex I subunit 6 family
HNS37_RS02635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNS37_RS02640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HNS37_RS02650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HNS37_RS02660	COG0649	NAD binding
HNS37_RS02660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNS37_RS02665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNS37_RS02670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNS37_RS02675	COG0583	DNA-binding transcription factor activity
HNS37_RS02680	COG0436	Aminotransferase
HNS37_RS02685	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HNS37_RS02690	COG0490	domain, Protein
HNS37_RS02690	COG0471	metal ion transport
HNS37_RS02695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNS37_RS02700	COG3013	Belongs to the UPF0304 family
HNS37_RS02705	COG3092	negative regulation of chromosome organization
HNS37_RS02710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HNS37_RS02715	COG0280	phosphate acetyltransferase
HNS37_RS02715	COG0857	belongs to the CobB CobQ family
HNS37_RS02735	COG3037	sugar-specific permease SgaT UlaA
HNS37_RS02745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNS37_RS02755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HNS37_RS02760	COG0625	glutathione transferase activity
HNS37_RS02765	COG1090	epimerase
HNS37_RS02770	COG0163	prenyltransferase activity
HNS37_RS02775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HNS37_RS02780	COG1286	toxin biosynthetic process
HNS37_RS02785	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HNS37_RS02790	COG0285	dihydrofolate synthase activity
HNS37_RS02795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HNS37_RS02800	COG0586	Pfam SNARE associated Golgi protein
HNS37_RS02805	COG0101	tRNA pseudouridine synthase activity
HNS37_RS02810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HNS37_RS02815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNS37_RS02820	COG2207	Transcriptional regulator
HNS37_RS02825	COG0697	spore germination
HNS37_RS02830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HNS37_RS02835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNS37_RS02835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HNS37_RS02855	COG3101	peptidyl-lysine hydroxylation
HNS37_RS02860	COG0730	response to heat
HNS37_RS02865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HNS37_RS02875	COG0783	Belongs to the Dps family
HNS37_RS02880	COG2840	Smr protein MutS2
HNS37_RS02885	COG2062	phosphohistidine phosphatase, SixA
HNS37_RS02890	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNS37_RS02890	COG1024	Enoyl-CoA hydratase
HNS37_RS02895	COG0183	Belongs to the thiolase family
HNS37_RS02900	COG3691	Protein conserved in bacteria
HNS37_RS02905	COG2067	long-chain fatty acid transport protein
HNS37_RS02950	COG1396	sequence-specific DNA binding
HNS37_RS02990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNS37_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
HNS37_RS03015	COG3530	Putative quorum-sensing-regulated virulence factor
HNS37_RS03020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HNS37_RS03025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HNS37_RS03030	COG3115	cell septum assembly
HNS37_RS03040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNS37_RS03045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNS37_RS03055	COG2190	(PTS) system
HNS37_RS03060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNS37_RS03065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HNS37_RS03070	COG4208	sulfate ABC transporter
HNS37_RS03075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HNS37_RS03085	COG2837	iron assimilation
HNS37_RS03095	COG0456	acetyltransferase
HNS37_RS03100	COG0408	coproporphyrinogen oxidase activity
HNS37_RS03110	COG1160	GTP binding
HNS37_RS03115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HNS37_RS03120	COG2976	Protein conserved in bacteria
HNS37_RS03125	COG0124	histidyl-tRNA synthetase
HNS37_RS03130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HNS37_RS03145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HNS37_RS03150	COG0105	UTP biosynthetic process
HNS37_RS03155	COG4953	penicillin-binding protein 1C
HNS37_RS03160	COG2373	Large extracellular alpha-helical protein
HNS37_RS03170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HNS37_RS03175	COG2975	iron-sulfur cluster assembly
HNS37_RS03180	COG0633	Ferredoxin
HNS37_RS03185	COG0443	Heat shock 70 kDa protein
HNS37_RS03190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HNS37_RS03195	COG0316	Belongs to the HesB IscA family
HNS37_RS03200	COG0822	iron-sulfur transferase activity
HNS37_RS03205	COG1104	cysteine desulfurase activity
HNS37_RS03210	COG1959	2 iron, 2 sulfur cluster binding
HNS37_RS03215	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HNS37_RS03220	COG0483	inositol monophosphate 1-phosphatase activity
HNS37_RS03235	COG2814	Major facilitator Superfamily
HNS37_RS03240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HNS37_RS03245	COG1017	nitric oxide dioxygenase activity
HNS37_RS03245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HNS37_RS03255	COG0347	Belongs to the P(II) protein family
HNS37_RS03260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNS37_RS03260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HNS37_RS03265	COG2204	response regulator
HNS37_RS03270	COG3170	Tfp pilus assembly protein FimV
HNS37_RS03275	COG2205	protein histidine kinase activity
HNS37_RS03280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HNS37_RS03280	COG0047	phosphoribosylformylglycinamidine synthase activity
HNS37_RS03285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HNS37_RS03290	COG3539	Fimbrial protein
HNS37_RS03295	COG3188	usher protein
HNS37_RS03300	COG3121	Chaperone
HNS37_RS03305	COG3539	Fimbrial protein
HNS37_RS03310	COG3539	Fimbrial protein
HNS37_RS03320	COG1280	lysine exporter protein (LysE YggA)
HNS37_RS03325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HNS37_RS03330	COG0736	holo-[acyl-carrier-protein] synthase activity
HNS37_RS03335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HNS37_RS03340	COG1381	Involved in DNA repair and RecF pathway recombination
HNS37_RS03345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HNS37_RS03350	COG0571	ribonuclease III activity
HNS37_RS03355	COG0681	Belongs to the peptidase S26 family
HNS37_RS03360	COG0481	GTPase activity
HNS37_RS03365	COG3086	response to oxidative stress
HNS37_RS03370	COG3026	antisigma factor binding
HNS37_RS03375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HNS37_RS03380	COG1595	DNA-templated transcription, initiation
HNS37_RS03385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HNS37_RS03390	COG0513	Belongs to the DEAD box helicase family
HNS37_RS03395	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HNS37_RS03400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HNS37_RS03405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HNS37_RS03410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HNS37_RS03415	COG0497	DNA recombination
HNS37_RS03425	COG2914	Belongs to the UPF0125 (RnfH) family
HNS37_RS03430	COG2867	negative regulation of translational initiation
HNS37_RS03435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HNS37_RS03460	COG1674	ftsk spoiiie
HNS37_RS03460	COG0531	amino acid
HNS37_RS03465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HNS37_RS03470	COG0732	type I restriction modification DNA specificity domain
HNS37_RS03520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HNS37_RS03575	COG2831	hemolysin activation secretion protein
HNS37_RS03580	COG3210	domain, Protein
HNS37_RS03670	COG0579	oxidoreductase
HNS37_RS03685	COG2249	NAD(P)H dehydrogenase (quinone) activity
HNS37_RS03690	COG2814	Major facilitator Superfamily
HNS37_RS03695	COG1620	l-lactate permease
HNS37_RS03700	COG0247	lactate metabolic process
HNS37_RS03705	COG1139	Iron-sulfur cluster binding protein
HNS37_RS03710	COG1556	Lactate utilization protein
HNS37_RS03725	COG0727	PFAM Uncharacterised protein family (UPF0153)
HNS37_RS03730	COG3738	Protein conserved in bacteria
HNS37_RS03740	COG2819	hydrolase of the alpha beta superfamily
HNS37_RS03745	COG4771	TonB-dependent receptor
HNS37_RS03755	COG1609	Transcriptional regulator
HNS37_RS03760	COG2017	converts alpha-aldose to the beta-anomer
HNS37_RS03765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HNS37_RS03770	COG1085	galactose-1-phosphate uridylyltransferase
HNS37_RS03775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HNS37_RS03785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HNS37_RS03790	COG0589	response to stress
HNS37_RS03795	COG4574	serine-type endopeptidase inhibitor activity
HNS37_RS03800	COG2841	Protein conserved in bacteria
HNS37_RS03870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HNS37_RS03880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HNS37_RS03885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HNS37_RS03895	COG0716	FMN binding
HNS37_RS03905	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HNS37_RS03910	COG0354	folic acid binding
HNS37_RS03920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HNS37_RS03920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HNS37_RS03925	COG0509	glycine decarboxylation via glycine cleavage system
HNS37_RS03930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HNS37_RS03935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNS37_RS03940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNS37_RS03945	COG0006	proline dipeptidase activity
HNS37_RS03950	COG3079	Belongs to the UPF0149 family
HNS37_RS03955	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HNS37_RS03965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HNS37_RS03975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNS37_RS03990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNS37_RS03995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HNS37_RS04000	COG0583	DNA-binding transcription factor activity
HNS37_RS04020	COG1279	arginine transmembrane transporter activity
HNS37_RS04030	COG3112	Uncharacterised protein family (UPF0231)
HNS37_RS04040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNS37_RS04045	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNS37_RS04050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HNS37_RS04055	COG2186	Transcriptional regulator
HNS37_RS04060	COG3023	N-Acetylmuramoyl-L-alanine amidase
HNS37_RS04065	COG4969	Belongs to the N-Me-Phe pilin family
HNS37_RS04070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HNS37_RS04080	COG0237	dephospho-CoA kinase activity
HNS37_RS04085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HNS37_RS04090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HNS37_RS04110	COG0653	protein targeting
HNS37_RS04125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HNS37_RS04135	COG0849	cell division
HNS37_RS04140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HNS37_RS04150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HNS37_RS04155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HNS37_RS04160	COG0772	Belongs to the SEDS family
HNS37_RS04165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HNS37_RS04170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNS37_RS04175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HNS37_RS04180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HNS37_RS04185	COG0768	penicillin binding
HNS37_RS04195	COG0275	rRNA processing
HNS37_RS04200	COG2001	Belongs to the MraZ family
HNS37_RS04210	COG1022	Amp-dependent synthetase and ligase
HNS37_RS04220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HNS37_RS04225	COG0473	3-isopropylmalate dehydrogenase activity
HNS37_RS04230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HNS37_RS04235	COG0066	3-isopropylmalate dehydratase activity
HNS37_RS04240	COG4533	DNA binding
HNS37_RS04245	COG3066	DNA modification
HNS37_RS04255	COG3657	addiction module killer protein
HNS37_RS04265	COG0010	Belongs to the arginase family
HNS37_RS04270	COG1166	arginine decarboxylase activity
HNS37_RS04275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HNS37_RS04300	COG1215	transferase activity, transferring glycosyl groups
HNS37_RS04305	COG0457	Tetratricopeptide repeat
HNS37_RS04305	COG3118	belongs to the thioredoxin family
HNS37_RS04320	COG0640	Transcriptional regulator
HNS37_RS04325	COG3091	SprT-like family
HNS37_RS04340	COG2239	Acts as a magnesium transporter
HNS37_RS04350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HNS37_RS04355	COG1151	hydroxylamine reductase activity
HNS37_RS04365	COG1115	amino acid carrier protein
HNS37_RS04380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HNS37_RS04385	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HNS37_RS04390	COG2353	YceI-like domain
HNS37_RS04395	COG3038	cytochrome b561
HNS37_RS04405	COG5295	Hep Hag repeat protein
HNS37_RS04415	COG3119	arylsulfatase activity
HNS37_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
HNS37_RS04455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HNS37_RS04460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS04460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNS37_RS04465	COG3716	PTS system mannose fructose sorbose family IID component
HNS37_RS04470	COG3715	PTS system
HNS37_RS04475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS04480	COG2222	sugar isomerase
HNS37_RS04490	COG1349	DNA-binding transcription factor activity
HNS37_RS04495	COG0641	radical SAM
HNS37_RS04500	COG3119	arylsulfatase activity
HNS37_RS04515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNS37_RS04520	COG0800	Aldolase
HNS37_RS04535	COG0384	phenazine biosynthesis protein PhzF
HNS37_RS04540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HNS37_RS04545	COG0640	Transcriptional regulator
HNS37_RS04555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HNS37_RS04575	COG2153	protein acetylation
HNS37_RS04585	COG2246	polysaccharide biosynthetic process
HNS37_RS04775	COG0484	heat shock protein binding
HNS37_RS04815	COG2974	May be involved in recombination
HNS37_RS04825	COG1846	Transcriptional regulator
HNS37_RS04885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HNS37_RS04935	COG0582	viral genome integration into host DNA
HNS37_RS04945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HNS37_RS04950	COG2501	S4 domain
HNS37_RS04955	COG1105	Belongs to the carbohydrate kinase PfkB family
HNS37_RS04960	COG0215	cysteine-tRNA ligase activity
HNS37_RS04965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HNS37_RS04970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNS37_RS04975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HNS37_RS04980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HNS37_RS04990	COG0668	transmembrane transport
HNS37_RS05000	COG4181	ATPase activity
HNS37_RS05005	COG2755	lipolytic protein G-D-S-L family
HNS37_RS05010	COG0300	oxidoreductase activity
HNS37_RS05015	COG3118	belongs to the thioredoxin family
HNS37_RS05020	COG0330	HflC and HflK could
HNS37_RS05030	COG0789	Transcriptional regulator
HNS37_RS05045	COG3735	TraB family
HNS37_RS05055	COG0737	Belongs to the 5'-nucleotidase family
HNS37_RS05060	COG4651	solute:proton antiporter activity
HNS37_RS05060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HNS37_RS05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNS37_RS05070	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HNS37_RS05075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HNS37_RS05080	COG0563	adenylate kinase activity
HNS37_RS05085	COG0326	Molecular chaperone. Has ATPase activity
HNS37_RS05090	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HNS37_RS05095	COG2962	Rard protein
HNS37_RS05115	COG4566	intracellular signal transduction
HNS37_RS05130	COG4589	Belongs to the CDS family
HNS37_RS05140	COG0583	DNA-binding transcription factor activity
HNS37_RS05150	COG0549	Belongs to the carbamate kinase family
HNS37_RS05160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HNS37_RS05165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HNS37_RS05170	COG1335	isochorismatase
HNS37_RS05185	COG0471	metal ion transport
HNS37_RS05210	COG3539	Fimbrial protein
HNS37_RS05280	COG0613	PHP domain protein
HNS37_RS05285	COG2190	(PTS) system
HNS37_RS05285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS05285	COG1263	PTS System
HNS37_RS05290	COG3711	transcriptional antiterminator
HNS37_RS05295	COG0456	acetyltransferase
HNS37_RS05300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HNS37_RS05310	COG4942	peptidase
HNS37_RS05310	COG1388	LysM domain
HNS37_RS05315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HNS37_RS05320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HNS37_RS05325	COG0585	pseudouridine synthase activity
HNS37_RS05330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HNS37_RS05335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HNS37_RS05345	COG0529	Catalyzes the synthesis of activated sulfate
HNS37_RS05350	COG2895	sulfate adenylyltransferase (ATP) activity
HNS37_RS05355	COG0175	sulfate reduction
HNS37_RS05360	COG1648	precorrin-2 dehydrogenase activity
HNS37_RS05360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HNS37_RS05365	COG0175	sulfate reduction
HNS37_RS05370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNS37_RS05375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HNS37_RS05380	COG0720	synthase
HNS37_RS05385	COG0602	queuosine metabolic process
HNS37_RS05440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HNS37_RS05445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HNS37_RS05450	COG2011	ABC-type metal ion transport system permease component
HNS37_RS05455	COG1464	Belongs to the NlpA lipoprotein family
HNS37_RS05465	COG1720	tRNA m6t6A37 methyltransferase activity
HNS37_RS05470	COG0442	prolyl-tRNA aminoacylation
HNS37_RS05475	COG3015	lipoprotein NlpE involved in copper resistance
HNS37_RS05480	COG4568	rho-dependent transcription termination
HNS37_RS05485	COG0037	tRNA processing
HNS37_RS05495	COG0825	malonyl-CoA metabolic process
HNS37_RS05505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HNS37_RS05510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNS37_RS05515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNS37_RS05520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HNS37_RS05525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNS37_RS05545	COG0575	Belongs to the CDS family
HNS37_RS05550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HNS37_RS05555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HNS37_RS05560	COG0233	cytoplasmic translational termination
HNS37_RS05565	COG0528	UMP kinase activity
HNS37_RS05570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HNS37_RS05575	COG0052	Belongs to the universal ribosomal protein uS2 family
HNS37_RS05585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HNS37_RS05590	COG2171	N-acyltransferase activity
HNS37_RS05600	COG0716	FMN binding
HNS37_RS05610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS05610	COG1263	PTS System
HNS37_RS05615	COG0564	pseudouridine synthase activity
HNS37_RS05620	COG3098	single-species biofilm formation
HNS37_RS05630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HNS37_RS05630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HNS37_RS05635	COG1611	Belongs to the LOG family
HNS37_RS05640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNS37_RS05645	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HNS37_RS05650	COG2363	Small membrane protein
HNS37_RS05655	COG0583	DNA-binding transcription factor activity
HNS37_RS05660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HNS37_RS05665	COG2166	iron-sulfur cluster assembly
HNS37_RS05670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HNS37_RS05675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HNS37_RS05695	COG0860	N-Acetylmuramoyl-L-alanine amidase
HNS37_RS05700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HNS37_RS05700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HNS37_RS05705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HNS37_RS05710	COG1074	ATP-dependent DNA helicase activity
HNS37_RS05715	COG1025	Belongs to the peptidase M16 family
HNS37_RS05720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HNS37_RS05750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HNS37_RS05760	COG0494	nUDIX hydrolase
HNS37_RS05765	COG4143	(ABC) transporter
HNS37_RS05770	COG1178	ABC-type Fe3 transport system permease component
HNS37_RS05775	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HNS37_RS05780	COG3311	Transcriptional regulator
HNS37_RS05790	COG0417	DNA replication proofreading
HNS37_RS05795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HNS37_RS05800	COG0564	pseudouridine synthase activity
HNS37_RS05805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HNS37_RS05810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HNS37_RS05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNS37_RS05820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HNS37_RS05825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HNS37_RS05830	COG2967	ApaG domain
HNS37_RS05835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HNS37_RS05855	COG2132	Multicopper oxidase
HNS37_RS05860	COG0204	Acyl-transferase
HNS37_RS05865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HNS37_RS05870	COG0187	DNA topoisomerase II activity
HNS37_RS05875	COG3150	esterase
HNS37_RS05880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HNS37_RS05885	COG0494	nUDIX hydrolase
HNS37_RS05890	COG1538	Outer membrane efflux protein
HNS37_RS05895	COG5463	Belongs to the UPF0441 family
HNS37_RS05900	COG0754	glutathionylspermidine amidase activity
HNS37_RS05905	COG3384	dioxygenase
HNS37_RS05910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HNS37_RS05920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HNS37_RS05920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNS37_RS05925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HNS37_RS05930	COG3025	triphosphatase activity
HNS37_RS05935	COG4991	sh3 domain protein
HNS37_RS05940	COG0617	tRNA 3'-terminal CCA addition
HNS37_RS05945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HNS37_RS05950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HNS37_RS05970	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HNS37_RS05975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HNS37_RS05980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HNS37_RS05985	COG0358	DNA primase activity
HNS37_RS06005	COG3157	Type VI secretion system effector, Hcp
HNS37_RS06030	COG3781	membrane
HNS37_RS06040	COG1294	oxidase, subunit
HNS37_RS06045	COG1271	oxidase subunit
HNS37_RS06050	COG0243	molybdopterin cofactor binding
HNS37_RS06055	COG0583	DNA-binding transcription factor activity
HNS37_RS06060	COG0840	transmembrane signaling receptor activity
HNS37_RS06065	COG0840	transmembrane signaling receptor activity
HNS37_RS06115	COG1358	cellular component organization or biogenesis
HNS37_RS06170	COG2376	Dihydroxyacetone kinase
HNS37_RS06175	COG1461	Dihydroxyacetone kinase
HNS37_RS06180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNS37_RS06180	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HNS37_RS06180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HNS37_RS06200	COG3539	Fimbrial protein
HNS37_RS06205	COG3121	Chaperone
HNS37_RS06210	COG3188	usher protein
HNS37_RS06235	COG2271	Major facilitator Superfamily
HNS37_RS06240	COG0469	pyruvate kinase activity
HNS37_RS06245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HNS37_RS06255	COG2851	Citrate transporter
HNS37_RS06260	COG0813	purine-nucleoside phosphorylase activity
HNS37_RS06265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HNS37_RS06270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HNS37_RS06275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HNS37_RS06280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HNS37_RS06285	COG0084	hydrolase, TatD family'
HNS37_RS06290	COG4667	esterase of the alpha-beta hydrolase superfamily
HNS37_RS06300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HNS37_RS06330	COG2813	Specifically methylates the guanine in position
HNS37_RS06345	COG1283	sodium-dependent phosphate transmembrane transporter activity
HNS37_RS06350	COG1785	Belongs to the alkaline phosphatase family
HNS37_RS06355	COG0675	Transposase, IS605 OrfB family
HNS37_RS06365	COG2382	esterase
HNS37_RS06385	COG0560	Phosphoserine phosphatase
HNS37_RS06390	COG3726	membrane protein affecting hemolysin expression
HNS37_RS06395	COG1328	CTP reductase activity
HNS37_RS06400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HNS37_RS06410	COG1124	(ABC) transporter
HNS37_RS06420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HNS37_RS06435	COG1216	Glycosyl transferase, family 2
HNS37_RS06450	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HNS37_RS06460	COG3260	NADH ubiquinone oxidoreductase 20
HNS37_RS06465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNS37_RS06470	COG3261	NADH dehydrogenase
HNS37_RS06470	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HNS37_RS06475	COG0651	ATP synthesis coupled electron transport
HNS37_RS06480	COG4237	Hydrogenase 4 membrane
HNS37_RS06485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HNS37_RS06490	COG0650	Formate hydrogenlyase subunit 4
HNS37_RS06495	COG0651	ATP synthesis coupled electron transport
HNS37_RS06500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HNS37_RS06505	COG0698	ribose 5-phosphate isomerase
HNS37_RS06510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HNS37_RS06525	COG3188	usher protein
HNS37_RS06530	COG3121	Chaperone
HNS37_RS06560	COG0702	epimerase
HNS37_RS06575	COG0459	protein refolding
HNS37_RS06580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HNS37_RS06595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HNS37_RS06600	COG1309	transcriptional regulator
HNS37_RS06615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HNS37_RS06620	COG1704	LemA family
HNS37_RS06635	COG2255	four-way junction helicase activity
HNS37_RS06640	COG4977	sequence-specific DNA binding
HNS37_RS06645	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HNS37_RS06650	COG0644	oxidoreductase
HNS37_RS06655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HNS37_RS06660	COG2086	electron transfer activity
HNS37_RS06665	COG1960	acyl-CoA dehydrogenase activity
HNS37_RS06670	COG2610	gluconate transmembrane transporter activity
HNS37_RS06685	COG1924	4 iron, 4 sulfur cluster binding
HNS37_RS06695	COG0318	PFAM AMP-dependent synthetase and ligase
HNS37_RS06700	COG2271	Major facilitator Superfamily
HNS37_RS06705	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HNS37_RS06710	COG0644	oxidoreductase
HNS37_RS06730	COG1960	acyl-CoA dehydrogenase activity
HNS37_RS06735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HNS37_RS06740	COG0318	PFAM AMP-dependent synthetase and ligase
HNS37_RS06745	COG1024	Enoyl-CoA hydratase
HNS37_RS06765	COG3397	chitin binding
HNS37_RS06805	COG0583	DNA-binding transcription factor activity
HNS37_RS06810	COG2137	regulation of response to DNA damage stimulus
HNS37_RS06830	COG2992	FlgJ-related protein
HNS37_RS06855	COG2610	gluconate transmembrane transporter activity
HNS37_RS06860	COG3265	gluconokinase activity
HNS37_RS06865	COG1609	Transcriptional regulator
HNS37_RS06880	COG1120	ATPase activity
HNS37_RS06885	COG0500	methyltransferase
HNS37_RS06890	COG0157	Belongs to the NadC ModD family
HNS37_RS06935	COG4790	Type iii secretion
HNS37_RS06980	COG2207	Transcriptional regulator
HNS37_RS07020	COG0789	Transcriptional regulator
HNS37_RS07030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNS37_RS07035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNS37_RS07060	COG4869	propanediol catabolic process
HNS37_RS07070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HNS37_RS07075	COG1882	Formate acetyltransferase
HNS37_RS07085	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HNS37_RS07090	COG1454	alcohol dehydrogenase
HNS37_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
HNS37_RS07125	COG2873	o-acetylhomoserine
HNS37_RS07145	COG3188	usher protein
HNS37_RS07150	COG3539	Fimbrial protein
HNS37_RS07170	COG1177	transmembrane transport
HNS37_RS07190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HNS37_RS07210	COG1448	Aminotransferase
HNS37_RS07220	COG0814	amino acid
HNS37_RS07225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HNS37_RS07235	COG0735	belongs to the Fur family
HNS37_RS07240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HNS37_RS07245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HNS37_RS07250	COG2937	Belongs to the GPAT DAPAT family
HNS37_RS07255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HNS37_RS07260	COG3161	chorismate lyase activity
HNS37_RS07265	COG0166	Belongs to the GPI family
HNS37_RS07270	COG0527	aspartate kinase activity
HNS37_RS07285	COG0646	methionine synthase
HNS37_RS07285	COG1410	methionine synthase
HNS37_RS07295	COG0129	dihydroxy-acid dehydratase activity
HNS37_RS07300	COG0800	Aldolase
HNS37_RS07305	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HNS37_RS07310	COG2224	Isocitrate lyase
HNS37_RS07315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HNS37_RS07320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HNS37_RS07330	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HNS37_RS07360	COG0138	bifunctional purine biosynthesis protein purh
HNS37_RS07365	COG0151	Belongs to the GarS family
HNS37_RS07380	COG3068	Protein conserved in bacteria
HNS37_RS07385	COG1515	deoxyribonuclease V activity
HNS37_RS07390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HNS37_RS07395	COG2816	NAD+ diphosphatase activity
HNS37_RS07405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HNS37_RS07410	COG0352	thiamine-phosphate diphosphorylase activity
HNS37_RS07415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HNS37_RS07420	COG2104	thiamine diphosphate biosynthetic process
HNS37_RS07425	COG2022	thiamine diphosphate biosynthetic process
HNS37_RS07435	COG5464	transposase or invertase
HNS37_RS07440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HNS37_RS07445	COG0085	RNA polymerase activity
HNS37_RS07450	COG0222	ribosome binding
HNS37_RS07455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HNS37_RS07460	COG0081	regulation of translation
HNS37_RS07465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HNS37_RS07470	COG0250	Participates in transcription elongation, termination and antitermination
HNS37_RS07485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HNS37_RS07490	COG0049	tRNA binding
HNS37_RS07495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HNS37_RS07505	COG2923	Belongs to the DsrF TusC family
HNS37_RS07510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HNS37_RS07515	COG2964	Protein conserved in bacteria
HNS37_RS07525	COG0545	Peptidyl-prolyl cis-trans isomerase
HNS37_RS07530	COG2900	Belongs to the SlyX family
HNS37_RS07535	COG1047	Peptidyl-prolyl cis-trans
HNS37_RS07540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HNS37_RS07550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HNS37_RS07555	COG0488	(ABC) transporter
HNS37_RS07560	COG0840	transmembrane signaling receptor activity
HNS37_RS07565	COG0840	transmembrane signaling receptor activity
HNS37_RS07570	COG0840	transmembrane signaling receptor activity
HNS37_RS07585	COG0429	hydrolase of the alpha beta-hydrolase fold
HNS37_RS07590	COG3089	Belongs to the UPF0270 family
HNS37_RS07595	COG3954	Phosphoribulokinase
HNS37_RS07600	COG1765	OsmC-like protein
HNS37_RS07605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HNS37_RS07610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HNS37_RS07620	COG0675	Transposase, IS605 OrfB family
HNS37_RS07630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HNS37_RS07640	COG0242	peptide deformylase activity
HNS37_RS07645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNS37_RS07645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNS37_RS07655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HNS37_RS07660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HNS37_RS07665	COG3084	Protein conserved in bacteria
HNS37_RS07670	COG0746	molybdenum cofactor guanylyltransferase activity
HNS37_RS07675	COG1763	Mo-molybdopterin cofactor biosynthetic process
HNS37_RS07680	COG0366	Alpha amylase catalytic
HNS37_RS07695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNS37_RS07700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HNS37_RS07710	COG1295	ribonuclease BN
HNS37_RS07715	COG1942	4-Oxalocrotonate Tautomerase
HNS37_RS07720	COG0612	Peptidase, M16
HNS37_RS07725	COG2199	diguanylate cyclase activity
HNS37_RS07725	COG2200	EAL domain
HNS37_RS07730	COG3210	domain, Protein
HNS37_RS07735	COG4608	Belongs to the ABC transporter superfamily
HNS37_RS07740	COG0444	Belongs to the ABC transporter superfamily
HNS37_RS07745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HNS37_RS07750	COG0601	transmembrane transport
HNS37_RS07755	COG0747	negative chemotaxis
HNS37_RS07760	COG2831	hemolysin activation secretion protein
HNS37_RS07775	COG5645	(Lipo)protein
HNS37_RS07780	COG0569	domain protein
HNS37_RS07780	COG2985	domain, Protein
HNS37_RS07785	COG3977	Valine--pyruvate aminotransferase
HNS37_RS07790	COG2818	Glycosylase
HNS37_RS07795	COG0752	glycyl-tRNA synthetase alpha subunit
HNS37_RS07800	COG0751	glycine-tRNA ligase activity
HNS37_RS07815	COG0823	Involved in the tonB-independent uptake of proteins
HNS37_RS07820	COG2860	membrane
HNS37_RS07825	COG0194	GDP metabolic process
HNS37_RS07830	COG1758	RNA polymerase activity
HNS37_RS07835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HNS37_RS07840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HNS37_RS07845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HNS37_RS07850	COG0786	glutamate:sodium symporter activity
HNS37_RS07855	COG2233	PERMEase
HNS37_RS07860	COG2982	Protein involved in outer membrane biogenesis
HNS37_RS07870	COG1187	pseudouridine synthase activity
HNS37_RS07875	COG0456	acetyltransferase
HNS37_RS07880	COG1490	D-aminoacyl-tRNA deacylase activity
HNS37_RS07885	COG1011	Hydrolase
HNS37_RS07950	COG2183	response to ionizing radiation
HNS37_RS07955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HNS37_RS07960	COG0745	RESPONSE REGULATOR receiver
HNS37_RS07965	COG2205	protein histidine kinase activity
HNS37_RS07970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HNS37_RS07975	COG0573	inorganic phosphate transmembrane transporter activity
HNS37_RS07980	COG0581	inorganic phosphate transmembrane transporter activity
HNS37_RS07990	COG0704	Plays a role in the regulation of phosphate uptake
HNS37_RS07995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HNS37_RS08005	COG0765	amino acid transport
HNS37_RS08030	COG1136	(ABC) transporter
HNS37_RS08045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HNS37_RS08050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HNS37_RS08055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HNS37_RS08060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HNS37_RS08070	COG0736	holo-[acyl-carrier-protein] synthase activity
HNS37_RS08080	COG2252	PERMEase
HNS37_RS08085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNS37_RS08105	COG1918	ferrous iron import across plasma membrane
HNS37_RS08110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HNS37_RS08125	COG2267	carboxylic ester hydrolase activity
HNS37_RS08135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HNS37_RS08135	COG0316	Belongs to the HesB IscA family
HNS37_RS08140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HNS37_RS08145	COG0705	Rhomboid family
HNS37_RS08150	COG1349	DNA-binding transcription factor activity
HNS37_RS08155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HNS37_RS08160	COG3189	MarR family transcriptional regulator
HNS37_RS08200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HNS37_RS08220	COG1124	(ABC) transporter
HNS37_RS08235	COG0601	transmembrane transport
HNS37_RS08240	COG0747	negative chemotaxis
HNS37_RS08245	COG2226	methyltransferase
HNS37_RS08260	COG3394	polysaccharide catabolic process
HNS37_RS08265	COG1486	melibiose metabolic process
HNS37_RS08270	COG2169	Transcriptional regulator
HNS37_RS08270	COG1917	Cupin 2, conserved barrel domain protein
HNS37_RS08275	COG1447	Phosphotransferase system cellobiose-specific component IIA
HNS37_RS08280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HNS37_RS08285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HNS37_RS08290	COG4607	ABC-type enterochelin transport system periplasmic component
HNS37_RS08295	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HNS37_RS08300	COG4605	iron ion homeostasis
HNS37_RS08305	COG4604	ABC transporter, ATP-binding protein
HNS37_RS08315	COG2271	Major facilitator Superfamily
HNS37_RS08320	COG4948	Mandelate Racemase Muconate Lactonizing
HNS37_RS08325	COG1802	Transcriptional regulator
HNS37_RS08335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNS37_RS08340	COG0800	Aldolase
HNS37_RS08355	COG0531	amino acid
HNS37_RS08360	COG1982	Orn Lys Arg decarboxylase major
HNS37_RS08365	COG0531	amino acid
HNS37_RS08375	COG0243	molybdopterin cofactor binding
HNS37_RS08380	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS08385	COG3302	dmso reductase anchor subunit
HNS37_RS08390	COG1609	Transcriptional regulator
HNS37_RS08400	COG2211	Major facilitator Superfamily
HNS37_RS08405	COG1285	pathogenesis
HNS37_RS08425	COG1737	Transcriptional regulator
HNS37_RS08430	COG2731	YhcH YjgK YiaL family protein
HNS37_RS08435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNS37_RS08445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HNS37_RS08450	COG3383	formate dehydrogenase (NAD+) activity
HNS37_RS08455	COG0733	neurotransmitter:sodium symporter activity
HNS37_RS08460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HNS37_RS08465	COG1263	PTS System
HNS37_RS08465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS08470	COG1737	Transcriptional regulator
HNS37_RS08475	COG1278	Cold shock
HNS37_RS08480	COG0564	pseudouridine synthase activity
HNS37_RS08485	COG3122	Protein conserved in bacteria
HNS37_RS08500	COG3501	Rhs element vgr protein
HNS37_RS08540	COG3188	usher protein
HNS37_RS08625	COG0582	viral genome integration into host DNA
HNS37_RS08640	COG0742	ribosomal rna small subunit methyltransferase
HNS37_RS08645	COG1028	Short-chain dehydrogenase reductase Sdr
HNS37_RS08655	COG0589	response to stress
HNS37_RS08665	COG0306	phosphate transporter
HNS37_RS08670	COG2081	HI0933 family
HNS37_RS08685	COG1741	Belongs to the pirin family
HNS37_RS08690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HNS37_RS08695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HNS37_RS08700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HNS37_RS08710	COG0494	nUDIX hydrolase
HNS37_RS08720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HNS37_RS08740	COG4796	Type ii and iii secretion system protein
HNS37_RS08745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HNS37_RS08750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HNS37_RS08765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HNS37_RS08770	COG0546	phosphoglycolate phosphatase activity
HNS37_RS08775	COG0180	Tryptophanyl-tRNA synthetase
HNS37_RS08780	COG2258	MOSC domain
HNS37_RS08785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HNS37_RS08790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HNS37_RS08795	COG3162	membrane
HNS37_RS08800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNS37_RS08805	COG2194	sulfuric ester hydrolase activity
HNS37_RS08810	COG1556	Lactate utilization protein
HNS37_RS08815	COG1139	Iron-sulfur cluster binding protein
HNS37_RS08820	COG0247	lactate metabolic process
HNS37_RS08845	COG2186	Transcriptional regulator
HNS37_RS08850	COG0477	Major facilitator Superfamily
HNS37_RS08855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNS37_RS08860	COG0714	Associated with various cellular activities
HNS37_RS08865	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HNS37_RS08870	COG2502	aspartate--ammonia ligase
HNS37_RS08875	COG1522	sequence-specific DNA binding
HNS37_RS08880	COG0716	FMN binding
HNS37_RS08885	COG0445	tRNA wobble uridine modification
HNS37_RS08890	COG0357	Ribosomal RNA small subunit methyltransferase G
HNS37_RS08895	COG3312	ion transport
HNS37_RS08900	COG0356	it plays a direct role in the translocation of protons across the membrane
HNS37_RS08910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HNS37_RS08915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HNS37_RS08920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HNS37_RS08925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HNS37_RS08930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HNS37_RS08935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HNS37_RS08940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HNS37_RS08945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HNS37_RS08985	COG3173	Aminoglycoside phosphotransferase
HNS37_RS09165	COG0673	inositol 2-dehydrogenase activity
HNS37_RS09170	COG1324	tolerance protein
HNS37_RS09255	COG3842	ATPase activity
HNS37_RS09260	COG1178	ABC-type Fe3 transport system permease component
HNS37_RS09265	COG1840	ABC-type Fe3 transport system, periplasmic component
HNS37_RS09270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNS37_RS09285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNS37_RS09295	COG1288	antiporter activity
HNS37_RS09330	COG3188	usher protein
HNS37_RS09355	COG3111	PFAM Bacterial OB fold (BOF) protein
HNS37_RS09365	COG1940	carbohydrate kinase activity
HNS37_RS09375	COG1215	transferase activity, transferring glycosyl groups
HNS37_RS09385	COG0457	Tetratricopeptide repeat
HNS37_RS09395	COG3706	GGDEF domain
HNS37_RS09400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HNS37_RS09405	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HNS37_RS09410	COG1368	sulfuric ester hydrolase activity
HNS37_RS09415	COG3276	selenocysteine insertion sequence binding
HNS37_RS09420	COG1921	L-seryl-tRNASec selenium transferase activity
HNS37_RS09425	COG3058	Necessary for formate dehydrogenase activity
HNS37_RS09430	COG2864	formate dehydrogenase
HNS37_RS09435	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS09445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HNS37_RS09465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNS37_RS09470	COG0583	DNA-binding transcription factor activity
HNS37_RS09515	COG1196	nuclear chromosome segregation
HNS37_RS09585	COG4974	Belongs to the 'phage' integrase family
HNS37_RS09590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HNS37_RS09595	COG0706	membrane insertase activity
HNS37_RS09600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HNS37_RS09605	COG0594	ribonuclease P activity
HNS37_RS09610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HNS37_RS09615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HNS37_RS09625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HNS37_RS09630	COG0187	DNA topoisomerase II activity
HNS37_RS09635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HNS37_RS09640	COG4106	trans-aconitate 2-methyltransferase activity
HNS37_RS09660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HNS37_RS09675	COG1561	YicC-like family, N-terminal region
HNS37_RS09680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HNS37_RS09685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HNS37_RS09690	COG1309	transcriptional regulator
HNS37_RS09695	COG0756	dUTP diphosphatase activity
HNS37_RS09700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HNS37_RS09705	COG2003	Belongs to the UPF0758 family
HNS37_RS09710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HNS37_RS09715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HNS37_RS09720	COG0438	transferase activity, transferring glycosyl groups
HNS37_RS09730	COG0297	glycogen (starch) synthase activity
HNS37_RS09745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HNS37_RS09750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HNS37_RS09760	COG1519	Transferase
HNS37_RS09765	COG0859	PFAM glycosyl transferase family 9
HNS37_RS09775	COG0438	transferase activity, transferring glycosyl groups
HNS37_RS09780	COG0859	PFAM glycosyl transferase family 9
HNS37_RS09785	COG0438	transferase activity, transferring glycosyl groups
HNS37_RS09800	COG0859	PFAM glycosyl transferase family 9
HNS37_RS09810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNS37_RS09815	COG0156	8-amino-7-oxononanoate synthase activity
HNS37_RS09820	COG1063	alcohol dehydrogenase
HNS37_RS09825	COG2861	carbohydrate metabolic process
HNS37_RS09830	COG4942	peptidase
HNS37_RS09835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNS37_RS09845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HNS37_RS09850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HNS37_RS09860	COG1045	serine acetyltransferase
HNS37_RS09865	COG1045	serine acetyltransferase
HNS37_RS09870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HNS37_RS09880	COG1442	glycosyl transferase family 8
HNS37_RS09880	COG1216	Glycosyl transferase, family 2
HNS37_RS09905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNS37_RS09935	COG2205	protein histidine kinase activity
HNS37_RS09940	COG0745	RESPONSE REGULATOR receiver
HNS37_RS09945	COG3678	ATP-independent chaperone mediated protein folding
HNS37_RS09950	COG2944	sequence-specific DNA binding
HNS37_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
HNS37_RS09960	COG0205	6-phosphofructokinase activity
HNS37_RS09965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HNS37_RS09970	COG0149	triose-phosphate isomerase activity
HNS37_RS09980	COG3152	Membrane
HNS37_RS09985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HNS37_RS09990	COG2814	Major facilitator Superfamily
HNS37_RS09995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HNS37_RS10005	COG3074	FtsZ-dependent cytokinesis
HNS37_RS10015	COG1396	sequence-specific DNA binding
HNS37_RS10020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HNS37_RS10025	COG1575	Belongs to the MenA family. Type 1 subfamily
HNS37_RS10030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HNS37_RS10035	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HNS37_RS10040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HNS37_RS10045	COG1609	Transcriptional regulator
HNS37_RS10050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HNS37_RS10055	COG0254	rRNA binding
HNS37_RS10065	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HNS37_RS10070	COG0626	cystathionine gamma-synthase activity
HNS37_RS10075	COG0527	aspartate kinase activity
HNS37_RS10075	COG0460	homoserine dehydrogenase
HNS37_RS10080	COG2862	Uncharacterized protein family, UPF0114
HNS37_RS10090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HNS37_RS10095	COG1216	Glycosyl transferase, family 2
HNS37_RS10105	COG0477	Major facilitator Superfamily
HNS37_RS10110	COG0583	DNA-binding transcription factor activity
HNS37_RS10130	COG0028	Belongs to the TPP enzyme family
HNS37_RS10135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HNS37_RS10140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HNS37_RS10145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HNS37_RS10150	COG0137	argininosuccinate synthase activity
HNS37_RS10155	COG0165	Argininosuccinate lyase
HNS37_RS10165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNS37_RS10180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HNS37_RS10185	COG4206	TonB-dependent receptor
HNS37_RS10190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HNS37_RS10225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HNS37_RS10235	COG1072	(Pantothenic acid kinase))
HNS37_RS10275	COG0051	transcription antitermination factor activity, RNA binding
HNS37_RS10280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HNS37_RS10285	COG0088	Forms part of the polypeptide exit tunnel
HNS37_RS10290	COG0089	rRNA binding
HNS37_RS10295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HNS37_RS10300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HNS37_RS10305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HNS37_RS10315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HNS37_RS10320	COG0255	Belongs to the universal ribosomal protein uL29 family
HNS37_RS10325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HNS37_RS10330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HNS37_RS10335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HNS37_RS10340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HNS37_RS10345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HNS37_RS10350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HNS37_RS10355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HNS37_RS10360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HNS37_RS10365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HNS37_RS10370	COG1841	ribosomal large subunit assembly
HNS37_RS10375	COG0200	Binds to the 23S rRNA
HNS37_RS10380	COG0201	protein transport
HNS37_RS10385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HNS37_RS10390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HNS37_RS10400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HNS37_RS10410	COG0203	ribosomal protein L17
HNS37_RS10415	COG0789	Transcriptional regulator
HNS37_RS10420	COG3036	rescue of stalled ribosome
HNS37_RS10425	COG1970	mechanosensitive ion channel activity
HNS37_RS10430	COG0569	domain protein
HNS37_RS10435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HNS37_RS10435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HNS37_RS10440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HNS37_RS10445	COG0242	peptide deformylase activity
HNS37_RS10450	COG0758	DNA mediated transformation
HNS37_RS10455	COG0551	DNA topoisomerase type I activity
HNS37_RS10460	COG0009	L-threonylcarbamoyladenylate synthase
HNS37_RS10465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HNS37_RS10475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HNS37_RS10515	COG0583	DNA-binding transcription factor activity
HNS37_RS10520	COG3085	chromosome segregation
HNS37_RS10525	COG0606	chelatase, subunit chli
HNS37_RS10540	COG3978	acetolactate synthase activity
HNS37_RS10550	COG0129	dihydroxy-acid dehydratase activity
HNS37_RS10555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HNS37_RS10565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HNS37_RS10580	COG0210	DNA helicase
HNS37_RS10585	COG0248	Ppx GppA phosphatase
HNS37_RS10590	COG0513	Belongs to the DEAD box helicase family
HNS37_RS10595	COG3118	belongs to the thioredoxin family
HNS37_RS10600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HNS37_RS10605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNS37_RS10615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HNS37_RS10620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HNS37_RS10625	COG1088	dTDP-glucose 4,6-dehydratase activity
HNS37_RS10630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HNS37_RS10635	COG0456	acetyltransferase
HNS37_RS10640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HNS37_RS10645	COG2244	polysaccharide biosynthetic process
HNS37_RS10650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HNS37_RS10660	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HNS37_RS10690	COG3071	HemY protein
HNS37_RS10695	COG2959	enzyme of heme biosynthesis
HNS37_RS10705	COG0181	hydroxymethylbilane synthase activity
HNS37_RS10715	COG1965	Belongs to the frataxin family
HNS37_RS10720	COG5567	small periplasmic lipoprotein
HNS37_RS10725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HNS37_RS10740	COG1011	Hydrolase
HNS37_RS10745	COG0210	DNA helicase
HNS37_RS10755	COG2962	Rard protein
HNS37_RS10760	COG2050	protein possibly involved in aromatic compounds catabolism
HNS37_RS10775	COG2267	carboxylic ester hydrolase activity
HNS37_RS10780	COG0561	phosphatase activity
HNS37_RS10790	COG3188	usher protein
HNS37_RS10795	COG3121	Chaperone
HNS37_RS10800	COG3539	Fimbrial protein
HNS37_RS10810	COG1511	domain protein
HNS37_RS10810	COG3264	Mechanosensitive ion channel
HNS37_RS10815	COG0688	phosphatidylethanolamine metabolic process
HNS37_RS10820	COG1162	GTPase activity
HNS37_RS10825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HNS37_RS10845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HNS37_RS10850	COG0802	atpase or kinase
HNS37_RS10855	COG0860	N-Acetylmuramoyl-L-alanine amidase
HNS37_RS10860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HNS37_RS10865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HNS37_RS10870	COG1923	regulation of RNA biosynthetic process
HNS37_RS10875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HNS37_RS10880	COG0330	HflC and HflK could
HNS37_RS10885	COG0330	HflC and HflK could
HNS37_RS10890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HNS37_RS10895	COG1959	2 iron, 2 sulfur cluster binding
HNS37_RS10900	COG0557	exoribonuclease II activity
HNS37_RS10905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HNS37_RS10910	COG0360	Binds together with S18 to 16S ribosomal RNA
HNS37_RS10915	COG2965	DNA replication, synthesis of RNA primer
HNS37_RS10920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HNS37_RS10925	COG0359	binds to the 23S rRNA
HNS37_RS10930	COG3061	Opacity-associated protein A
HNS37_RS10935	COG0254	rRNA binding
HNS37_RS10940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HNS37_RS10945	COG3443	Belongs to the bacterial solute-binding protein 9 family
HNS37_RS10955	COG1012	belongs to the aldehyde dehydrogenase family
HNS37_RS10960	COG0545	Peptidyl-prolyl cis-trans isomerase
HNS37_RS10970	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HNS37_RS10980	COG1253	flavin adenine dinucleotide binding
HNS37_RS10985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNS37_RS10990	COG0729	surface antigen
HNS37_RS10995	COG2911	Protein conserved in bacteria
HNS37_RS11000	COG2105	PFAM AIG2 family protein
HNS37_RS11020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HNS37_RS11025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HNS37_RS11030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HNS37_RS11035	COG1438	arginine binding
HNS37_RS11040	COG0039	L-malate dehydrogenase activity
HNS37_RS11045	COG3423	Transcriptional regulator
HNS37_RS11060	COG0142	geranyltranstransferase activity
HNS37_RS11065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HNS37_RS11070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HNS37_RS11075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HNS37_RS11080	COG2027	D-alanyl-D-alanine carboxypeptidase
HNS37_RS11090	COG1534	Rna-binding protein
HNS37_RS11095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HNS37_RS11100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HNS37_RS11105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HNS37_RS11110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HNS37_RS11115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HNS37_RS11130	COG0779	Required for maturation of 30S ribosomal subunits
HNS37_RS11135	COG0195	Participates in both transcription termination and antitermination
HNS37_RS11140	COG3064	Membrane
HNS37_RS11140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HNS37_RS11145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HNS37_RS11150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HNS37_RS11155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HNS37_RS11160	COG1185	polyribonucleotide nucleotidyltransferase activity
HNS37_RS11170	COG0513	Belongs to the DEAD box helicase family
HNS37_RS11190	COG3275	phosphorelay sensor kinase activity
HNS37_RS11195	COG1566	PFAM secretion protein HlyD family protein
HNS37_RS11210	COG0826	peptidase U32
HNS37_RS11215	COG0826	peptidase U32
HNS37_RS11220	COG3154	lipid carrier protein
HNS37_RS11225	COG3153	acetyltransferase
HNS37_RS11230	COG2827	Endonuclease containing a URI domain
HNS37_RS11255	COG0602	queuosine metabolic process
HNS37_RS11260	COG1328	CTP reductase activity
HNS37_RS11265	COG0251	oxidation-reduction process
HNS37_RS11270	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HNS37_RS11275	COG0540	Belongs to the ATCase OTCase family
HNS37_RS11285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HNS37_RS11295	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HNS37_RS11310	COG0456	acetyltransferase
HNS37_RS11315	COG0525	valine-tRNA ligase activity
HNS37_RS11320	COG2927	DNA polymerase III (CHI subunit)
HNS37_RS11325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HNS37_RS11330	COG0795	lipopolysaccharide-transporting ATPase activity
HNS37_RS11335	COG0795	lipopolysaccharide-transporting ATPase activity
HNS37_RS11340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNS37_RS11350	COG0582	viral genome integration into host DNA
HNS37_RS11365	COG1401	restriction endodeoxyribonuclease activity
HNS37_RS11385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HNS37_RS11390	COG1690	Belongs to the RtcB family
HNS37_RS11395	COG1349	DNA-binding transcription factor activity
HNS37_RS11400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HNS37_RS11410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HNS37_RS11415	COG1263	PTS System
HNS37_RS11415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS11435	COG0028	Belongs to the TPP enzyme family
HNS37_RS11440	COG0440	acetolactate synthase activity
HNS37_RS11460	COG2252	PERMEase
HNS37_RS11465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNS37_RS11470	COG0025	NhaP-type Na H and K H
HNS37_RS11480	COG0583	DNA-binding transcription factor activity
HNS37_RS11485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HNS37_RS11495	COG3753	Protein conserved in bacteria
HNS37_RS11510	COG0586	Pfam SNARE associated Golgi protein
HNS37_RS11515	COG1322	Protein conserved in bacteria
HNS37_RS11520	COG2226	methyltransferase
HNS37_RS11525	COG3165	ubiquinone biosynthetic process from chorismate
HNS37_RS11535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HNS37_RS11540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HNS37_RS11545	COG0805	protein transport
HNS37_RS11560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HNS37_RS11570	COG0183	Belongs to the thiolase family
HNS37_RS11575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNS37_RS11575	COG1024	Enoyl-CoA hydratase
HNS37_RS11580	COG0006	proline dipeptidase activity
HNS37_RS11585	COG1739	Uncharacterized protein family UPF0029
HNS37_RS11590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HNS37_RS11625	COG1914	H( )-stimulated, divalent metal cation uptake system
HNS37_RS11630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HNS37_RS11635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HNS37_RS11640	COG4770	biotin carboxylase activity
HNS37_RS11645	COG0730	response to heat
HNS37_RS11660	COG0583	DNA-binding transcription factor activity
HNS37_RS11665	COG2197	response regulator
HNS37_RS11670	COG3850	Histidine kinase
HNS37_RS11675	COG2223	nitrite transmembrane transporter activity
HNS37_RS11680	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HNS37_RS11685	COG1140	nitrate reductase beta subunit
HNS37_RS11690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HNS37_RS11695	COG2181	nitrate reductase activity
HNS37_RS11700	COG1304	FMN binding
HNS37_RS11720	COG3604	Transcriptional regulator
HNS37_RS11725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HNS37_RS11730	COG0375	protein maturation
HNS37_RS11735	COG0298	carbon dioxide binding
HNS37_RS11740	COG2076	Multidrug Resistance protein
HNS37_RS11745	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HNS37_RS11750	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HNS37_RS11755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HNS37_RS11760	COG1053	succinate dehydrogenase
HNS37_RS11765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HNS37_RS11770	COG0584	glycerophosphoryl diester phosphodiesterase
HNS37_RS11775	COG2271	Major facilitator Superfamily
HNS37_RS11780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HNS37_RS11790	COG0247	lactate metabolic process
HNS37_RS11800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HNS37_RS11805	COG0425	Belongs to the sulfur carrier protein TusA family
HNS37_RS11820	COG2217	Heavy metal translocating P-type atpase
HNS37_RS11825	COG3714	YhhN family
HNS37_RS11835	COG3776	membrane
HNS37_RS11840	COG0742	ribosomal rna small subunit methyltransferase
HNS37_RS11845	COG0552	protein localization to endoplasmic reticulum
HNS37_RS11850	COG2884	Cell division ATP-binding protein ftsE
HNS37_RS11855	COG2177	Part of the ABC transporter FtsEX involved in
HNS37_RS11865	COG1929	Belongs to the glycerate kinase type-1 family
HNS37_RS11875	COG2814	Major facilitator Superfamily
HNS37_RS11880	COG1846	Transcriptional regulator
HNS37_RS11885	COG0501	Belongs to the peptidase M48B family
HNS37_RS11890	COG3842	ATPase activity
HNS37_RS11895	COG0395	ABC-type sugar transport system, permease component
HNS37_RS11905	COG1653	transport
HNS37_RS11910	COG0584	glycerophosphoryl diester phosphodiesterase
HNS37_RS11915	COG2807	transmembrane transport
HNS37_RS11930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HNS37_RS11935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HNS37_RS11940	COG2264	protein methyltransferase activity
HNS37_RS11945	COG4145	pantothenate transmembrane transporter activity
HNS37_RS11950	COG3924	membrane
HNS37_RS11955	COG0439	Biotin carboxylase
HNS37_RS11960	COG0511	ligase activity, forming carbon-carbon bonds
HNS37_RS11965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HNS37_RS11970	COG0604	alcohol dehydrogenase
HNS37_RS11975	COG1077	Cell shape determining protein MreB Mrl
HNS37_RS11980	COG1792	Involved in formation and maintenance of cell shape
HNS37_RS11985	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HNS37_RS11990	COG0424	maF-like protein
HNS37_RS11995	COG1530	ribonuclease E activity
HNS37_RS12000	COG3164	Protein of unknown function
HNS37_RS12005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNS37_RS12010	COG0312	modulator of DNA gyrase
HNS37_RS12020	COG2732	(Barnase) inhibitor
HNS37_RS12025	COG3028	Belongs to the UPF0307 family
HNS37_RS12030	COG0312	modulator of DNA gyrase
HNS37_RS12035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HNS37_RS12040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HNS37_RS12045	COG1660	Displays ATPase and GTPase activities
HNS37_RS12055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HNS37_RS12060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HNS37_RS12065	COG1137	ATPase activity
HNS37_RS12070	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HNS37_RS12075	COG3117	lipopolysaccharide transmembrane transporter activity
HNS37_RS12080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HNS37_RS12085	COG0517	IMP dehydrogenase activity
HNS37_RS12085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HNS37_RS12090	COG0530	calcium, potassium:sodium antiporter activity
HNS37_RS12095	COG1127	ABC transporter
HNS37_RS12100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HNS37_RS12105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HNS37_RS12110	COG2854	intermembrane phospholipid transfer
HNS37_RS12120	COG5007	Belongs to the BolA IbaG family
HNS37_RS12125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HNS37_RS12145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNS37_RS12150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNS37_RS12155	COG3105	Protein conserved in bacteria
HNS37_RS12160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HNS37_RS12165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HNS37_RS12170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HNS37_RS12175	COG0625	glutathione transferase activity
HNS37_RS12180	COG2969	positive regulation of protein catabolic process
HNS37_RS12190	COG1473	amidohydrolase
HNS37_RS12195	COG3069	C4-dicarboxylate transmembrane transporter activity
HNS37_RS12200	COG0493	'glutamate synthase
HNS37_RS12205	COG0070	glutamate synthase
HNS37_RS12205	COG0069	glutamate synthase activity
HNS37_RS12205	COG0067	glutamate synthase
HNS37_RS12210	COG0784	Response regulator, receiver
HNS37_RS12210	COG5002	protein histidine kinase activity
HNS37_RS12210	COG2198	Histidine kinase
HNS37_RS12215	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HNS37_RS12220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNS37_RS12225	COG2207	Transcriptional regulator
HNS37_RS12230	COG0829	nickel cation binding
HNS37_RS12235	COG0831	urea catabolic process
HNS37_RS12240	COG0832	Belongs to the urease beta subunit family
HNS37_RS12245	COG0804	urea catabolic process
HNS37_RS12250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HNS37_RS12255	COG0830	nickel cation binding
HNS37_RS12260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HNS37_RS12265	COG2823	Periplasmic or secreted lipoprotein
HNS37_RS12270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HNS37_RS12275	COG0792	nuclease activity
HNS37_RS12285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HNS37_RS12295	COG1741	Belongs to the pirin family
HNS37_RS12300	COG0583	DNA-binding transcription factor activity
HNS37_RS12305	COG2259	Doxx family
HNS37_RS12315	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HNS37_RS12320	COG4575	ribosome binding
HNS37_RS12325	COG0586	Pfam SNARE associated Golgi protein
HNS37_RS12330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HNS37_RS12335	COG0446	pyridine nucleotide-disulphide oxidoreductase
HNS37_RS12335	COG1902	pentaerythritol trinitrate reductase activity
HNS37_RS12345	COG0612	Peptidase, M16
HNS37_RS12350	COG4178	(ABC) transporter
HNS37_RS12355	COG4771	TonB-dependent receptor
HNS37_RS12365	COG1595	DNA-templated transcription, initiation
HNS37_RS12375	COG0488	(ABC) transporter
HNS37_RS12380	COG0741	lytic transglycosylase activity
HNS37_RS12385	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HNS37_RS12390	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HNS37_RS12395	COG0406	alpha-ribazole phosphatase activity
HNS37_RS12400	COG3708	Transcriptional regulator
HNS37_RS12400	COG2207	Transcriptional regulator
HNS37_RS12405	COG3045	CreA protein
HNS37_RS12410	COG0745	RESPONSE REGULATOR receiver
HNS37_RS12420	COG0083	homoserine kinase activity
HNS37_RS12435	COG3022	response to hydroperoxide
HNS37_RS12440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HNS37_RS12460	COG0521	Mo-molybdopterin cofactor biosynthetic process
HNS37_RS12465	COG0443	Heat shock 70 kDa protein
HNS37_RS12470	COG0484	heat shock protein binding
HNS37_RS12480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HNS37_RS12485	COG0583	DNA-binding transcription factor activity
HNS37_RS12490	COG0268	Binds directly to 16S ribosomal RNA
HNS37_RS12500	COG0196	riboflavin kinase activity
HNS37_RS12505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HNS37_RS12510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HNS37_RS12515	COG1047	Peptidyl-prolyl cis-trans
HNS37_RS12520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HNS37_RS12525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HNS37_RS12545	COG1388	LysM domain
HNS37_RS12545	COG1470	cell adhesion involved in biofilm formation
HNS37_RS12555	COG1979	alcohol dehydrogenase
HNS37_RS12560	COG2226	methyltransferase
HNS37_RS12570	COG0626	cystathionine gamma-synthase activity
HNS37_RS12575	COG0811	peptide transport
HNS37_RS12580	COG0848	biopolymer transport protein
HNS37_RS12585	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HNS37_RS12590	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS12595	COG5557	Pfam Polysulphide reductase, NrfD
HNS37_RS12600	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HNS37_RS12605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HNS37_RS12610	COG1773	rubredoxin
HNS37_RS12615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HNS37_RS12620	COG0298	carbon dioxide binding
HNS37_RS12625	COG0409	Hydrogenase expression formation protein
HNS37_RS12630	COG0309	Hydrogenase expression formation protein (HypE)
HNS37_RS12635	COG2391	methyltransferase activity
HNS37_RS12640	COG0425	Belongs to the sulfur carrier protein TusA family
HNS37_RS12645	COG2974	May be involved in recombination
HNS37_RS12655	COG0737	Belongs to the 5'-nucleotidase family
HNS37_RS12660	COG3719	Belongs to the RNase T2 family
HNS37_RS12665	COG0737	Belongs to the 5'-nucleotidase family
HNS37_RS12675	COG0419	ATPase involved in DNA repair
HNS37_RS12680	COG0420	3'-5' exonuclease activity
HNS37_RS12690	COG5002	protein histidine kinase activity
HNS37_RS12695	COG1114	Component of the transport system for branched-chain amino acids
HNS37_RS12705	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HNS37_RS12710	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS12720	COG2414	aldehyde ferredoxin oxidoreductase
HNS37_RS12725	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS12735	COG0450	alkyl hydroperoxide reductase
HNS37_RS12740	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HNS37_RS12745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HNS37_RS12750	COG0343	queuine tRNA-ribosyltransferase activity
HNS37_RS12755	COG1862	Preprotein translocase
HNS37_RS12760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HNS37_RS12765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HNS37_RS12770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HNS37_RS12775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HNS37_RS12775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HNS37_RS12780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HNS37_RS12785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HNS37_RS12795	COG2824	Alkylphosphonate utilization operon protein PhnA
HNS37_RS12810	COG1609	Transcriptional regulator
HNS37_RS12815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNS37_RS12820	COG1879	ABC-type sugar transport system periplasmic component
HNS37_RS12825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HNS37_RS12830	COG1129	ABC transporter
HNS37_RS12835	COG1869	D-ribose catabolic process
HNS37_RS12840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HNS37_RS12845	COG0142	geranyltranstransferase activity
HNS37_RS12855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HNS37_RS12855	COG0301	tRNA thio-modification
HNS37_RS12860	COG0693	protein deglycase activity
HNS37_RS12865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HNS37_RS12870	COG1666	GTP binding
HNS37_RS12875	COG2814	Major facilitator Superfamily
HNS37_RS12880	COG0109	protoheme IX farnesyltransferase activity
HNS37_RS12885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HNS37_RS12890	COG1845	cytochrome c oxidase, subunit III
HNS37_RS12895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HNS37_RS12900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HNS37_RS12910	COG0513	Belongs to the DEAD box helicase family
HNS37_RS12915	COG2223	nitrite transmembrane transporter activity
HNS37_RS12920	COG3056	Lipoprotein
HNS37_RS12930	COG0675	Transposase, IS605 OrfB family
HNS37_RS12935	COG0271	Belongs to the BolA IbaG family
HNS37_RS12940	COG0544	peptidyl-prolyl cis-trans isomerase activity
HNS37_RS12945	COG0740	serine-type endopeptidase activity
HNS37_RS12950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HNS37_RS12955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HNS37_RS12960	COG0776	regulation of translation
HNS37_RS12965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNS37_RS12970	COG1555	photosystem II stabilization
HNS37_RS12970	COG1596	polysaccharide export
HNS37_RS12975	COG0824	Thioesterase
HNS37_RS12980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HNS37_RS12985	COG1522	sequence-specific DNA binding
HNS37_RS12990	COG1132	(ABC) transporter
HNS37_RS12995	COG1132	(ABC) transporter
HNS37_RS13000	COG0347	Belongs to the P(II) protein family
HNS37_RS13005	COG0004	ammonium transporteR
HNS37_RS13010	COG1946	Acyl-CoA thioesterase
HNS37_RS13030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNS37_RS13035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNS37_RS13040	COG1309	transcriptional regulator
HNS37_RS13045	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HNS37_RS13050	COG3264	Mechanosensitive ion channel
HNS37_RS13050	COG1196	nuclear chromosome segregation
HNS37_RS13065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HNS37_RS13075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HNS37_RS13080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HNS37_RS13085	COG1966	Carbon starvation protein
HNS37_RS13090	COG2879	small protein
HNS37_RS13095	COG0523	cobalamin synthesis protein
HNS37_RS13105	COG3069	C4-dicarboxylate transmembrane transporter activity
HNS37_RS13110	COG2195	Cleaves the N-terminal amino acid of tripeptides
HNS37_RS13120	COG0534	Mate efflux family protein
HNS37_RS13125	COG0673	inositol 2-dehydrogenase activity
HNS37_RS13130	COG5564	TIM-barrel signal transduction protein
HNS37_RS13135	COG5441	Belongs to the UPF0261 family
HNS37_RS13170	COG2132	Multicopper oxidase
HNS37_RS13180	COG0288	reversible hydration of carbon dioxide
HNS37_RS13185	COG1131	(ABC) transporter
HNS37_RS13190	COG0842	Transport permease protein
HNS37_RS13195	COG0477	Major facilitator Superfamily
HNS37_RS13205	COG0501	Belongs to the peptidase M48B family
HNS37_RS13220	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS13225	COG0243	molybdopterin cofactor binding
HNS37_RS13235	COG2837	iron assimilation
HNS37_RS13250	COG4633	Protein conserved in bacteria
HNS37_RS13265	COG0754	glutathionylspermidine amidase activity
HNS37_RS13270	COG0583	DNA-binding transcription factor activity
HNS37_RS13275	COG2610	gluconate transmembrane transporter activity
HNS37_RS13280	COG3048	D-serine ammonia-lyase activity
HNS37_RS13285	COG3842	ATPase activity
HNS37_RS13295	COG1840	ABC-type Fe3 transport system, periplasmic component
HNS37_RS13300	COG2271	Major facilitator Superfamily
HNS37_RS13305	COG3851	Histidine kinase
HNS37_RS13315	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HNS37_RS13320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HNS37_RS13325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HNS37_RS13330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HNS37_RS13350	COG1489	DNA binding
HNS37_RS13355	COG1643	Atp-dependent helicase
HNS37_RS13360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNS37_RS13365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HNS37_RS13370	COG0316	Belongs to the HesB IscA family
HNS37_RS13380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HNS37_RS13390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HNS37_RS13395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HNS37_RS13400	COG3956	TIGRFAM MazG family protein
HNS37_RS13405	COG0504	CTP synthase activity
HNS37_RS13410	COG0148	phosphopyruvate hydratase activity
HNS37_RS13415	COG0471	metal ion transport
HNS37_RS13420	COG3961	Belongs to the TPP enzyme family
HNS37_RS13425	COG0741	lytic transglycosylase activity
HNS37_RS13425	COG1388	LysM domain
HNS37_RS13430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNS37_RS13435	COG2226	methyltransferase
HNS37_RS13440	COG0328	RNA-DNA hybrid ribonuclease activity
HNS37_RS13445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HNS37_RS13480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HNS37_RS13485	COG1120	ATPase activity
HNS37_RS13495	COG4264	IucA IucC family
HNS37_RS13505	COG0019	diaminopimelate decarboxylase activity
HNS37_RS13510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNS37_RS13515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HNS37_RS13520	COG2814	Major facilitator Superfamily
HNS37_RS13535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HNS37_RS13540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HNS37_RS13545	COG0126	phosphoglycerate kinase activity
HNS37_RS13555	COG2314	TM2 domain
HNS37_RS13560	COG3104	oligopeptide transport
HNS37_RS13575	COG1846	Transcriptional regulator
HNS37_RS13580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HNS37_RS13595	COG1234	tRNA 3'-trailer cleavage
HNS37_RS13600	COG3539	Fimbrial protein
HNS37_RS13605	COG3188	usher protein
HNS37_RS13610	COG3121	Chaperone
HNS37_RS13625	COG0582	viral genome integration into host DNA
HNS37_RS13630	COG3539	Fimbrial protein
HNS37_RS13640	COG3188	usher protein
HNS37_RS13660	COG3539	Fimbrial protein
HNS37_RS13675	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HNS37_RS13685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HNS37_RS13690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HNS37_RS13740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNS37_RS13745	COG1554	hydrolase, family 65, central catalytic
HNS37_RS13750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HNS37_RS13750	COG1263	PTS System
HNS37_RS13760	COG2207	Transcriptional regulator
HNS37_RS13760	COG3708	Transcriptional regulator
HNS37_RS13790	COG2274	protein secretion by the type I secretion system
HNS37_RS13800	COG1309	transcriptional regulator
HNS37_RS13805	COG0531	amino acid
HNS37_RS13810	COG1982	Orn Lys Arg decarboxylase major
HNS37_RS13835	COG0741	lytic transglycosylase activity
HNS37_RS13840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HNS37_RS13845	COG1194	a g-specific adenine glycosylase
HNS37_RS13855	COG3171	Protein conserved in bacteria
HNS37_RS13860	COG2066	Belongs to the glutaminase family
HNS37_RS13870	COG4607	ABC-type enterochelin transport system periplasmic component
HNS37_RS13875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HNS37_RS13880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HNS37_RS13885	COG0762	integral membrane protein
HNS37_RS13890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HNS37_RS13895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HNS37_RS13900	COG2805	Type II/IV secretion system protein
HNS37_RS13905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HNS37_RS13910	COG1678	Uncharacterized ACR, COG1678
HNS37_RS13915	COG0189	ligase activity
HNS37_RS13920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HNS37_RS13940	COG0583	DNA-binding transcription factor activity
HNS37_RS13945	COG0583	DNA-binding transcription factor activity
HNS37_RS13955	COG1960	acyl-CoA dehydrogenase activity
HNS37_RS13960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HNS37_RS13965	COG0121	glutamine amidotransferase
HNS37_RS13970	COG3034	peptidoglycan biosynthetic process
HNS37_RS13975	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HNS37_RS13980	COG1805	sodium ion transport
HNS37_RS13985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HNS37_RS13990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HNS37_RS13995	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HNS37_RS14000	COG2871	sodium ion transport
HNS37_RS14005	COG1477	protein flavinylation
HNS37_RS14010	COG2991	Protein conserved in bacteria
HNS37_RS14015	COG3237	CsbD-like
HNS37_RS14025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HNS37_RS14030	COG4774	siderophore transport
HNS37_RS14035	COG2195	Cleaves the N-terminal amino acid of tripeptides
HNS37_RS14040	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HNS37_RS14055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HNS37_RS14060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HNS37_RS14065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HNS37_RS14070	COG0318	PFAM AMP-dependent synthetase and ligase
HNS37_RS14070	COG0204	Acyl-transferase
HNS37_RS14075	COG2814	Major facilitator Superfamily
HNS37_RS14080	COG1546	Belongs to the CinA family
HNS37_RS14085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HNS37_RS14090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HNS37_RS14095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HNS37_RS14125	COG2918	glutathione biosynthetic process
HNS37_RS14130	COG1854	S-ribosylhomocysteine lyase activity
HNS37_RS14135	COG4536	flavin adenine dinucleotide binding
HNS37_RS14140	COG4137	Cytochrome C assembly protein
HNS37_RS14145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HNS37_RS14150	COG0228	four-way junction DNA binding
HNS37_RS14160	COG0336	Belongs to the RNA methyltransferase TrmD family
HNS37_RS14165	COG0335	large ribosomal subunit rRNA binding
HNS37_RS14170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HNS37_RS14175	COG0287	Prephenate dehydrogenase
HNS37_RS14175	COG1605	Chorismate mutase
HNS37_RS14185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HNS37_RS14190	COG0077	Prephenate dehydratase
HNS37_RS14190	COG1605	Chorismate mutase
HNS37_RS14195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HNS37_RS14200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HNS37_RS14205	COG0564	pseudouridine synthase activity
HNS37_RS14215	COG0542	response to heat
HNS37_RS14245	COG5544	Lipoprotein
HNS37_RS14250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HNS37_RS14255	COG1042	CoA-binding domain protein
HNS37_RS14255	COG0045	succinate-CoA ligase (ADP-forming) activity
HNS37_RS14255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNS37_RS14265	COG5160	protein modification by small protein removal
HNS37_RS14270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HNS37_RS14275	COG2814	Major facilitator Superfamily
HNS37_RS14280	COG1566	PFAM secretion protein HlyD family protein
HNS37_RS14290	COG2814	Major facilitator Superfamily
HNS37_RS14295	COG1335	isochorismatase
HNS37_RS14300	COG1846	Transcriptional regulator
HNS37_RS14305	COG2814	Major facilitator Superfamily
HNS37_RS14310	COG1629	transport
HNS37_RS14315	COG2113	Glycine betaine
HNS37_RS14320	COG4176	ABC-type proline glycine betaine transport system permease component
HNS37_RS14325	COG4175	Glycine betaine
HNS37_RS14340	COG1780	Probably involved in ribonucleotide reductase function
HNS37_RS14350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HNS37_RS14365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HNS37_RS14370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HNS37_RS14375	COG0321	lipoyl(octanoyl) transferase activity
HNS37_RS14385	COG1686	Belongs to the peptidase S11 family
HNS37_RS14390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HNS37_RS14395	COG0772	Belongs to the SEDS family
HNS37_RS14400	COG0768	penicillin binding
HNS37_RS14405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HNS37_RS14410	COG0799	negative regulation of ribosome biogenesis
HNS37_RS14425	COG1466	dna polymerase III delta subunit
HNS37_RS14430	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HNS37_RS14435	COG0495	leucyl-tRNA aminoacylation
HNS37_RS14440	COG1126	abc transporter atp-binding protein
HNS37_RS14445	COG0765	amino acid transport
HNS37_RS14450	COG0765	amino acid transport
HNS37_RS14475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNS37_RS14485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HNS37_RS14495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HNS37_RS14500	COG1702	phosphate starvation-inducible protein PhoH
HNS37_RS14505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNS37_RS14510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNS37_RS14565	COG1846	Transcriptional regulator
HNS37_RS14565	COG1940	carbohydrate kinase activity
HNS37_RS14570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HNS37_RS14575	COG0363	glucosamine-6-phosphate deaminase activity
HNS37_RS14585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNS37_RS14595	COG3739	integral membrane protein
HNS37_RS14600	COG0735	belongs to the Fur family
HNS37_RS14605	COG0716	FMN binding
HNS37_RS14615	COG0596	Alpha beta hydrolase
HNS37_RS14620	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HNS37_RS14625	COG0033	Phosphoglucomutase
HNS37_RS14630	COG4807	Protein conserved in bacteria
HNS37_RS14635	COG3609	addiction module antidote protein, CC2985 family
HNS37_RS14650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HNS37_RS14660	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HNS37_RS14665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HNS37_RS14670	COG0714	Associated with various cellular activities
HNS37_RS14680	COG2814	Major facilitator Superfamily
HNS37_RS14700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HNS37_RS14705	COG1053	succinate dehydrogenase
HNS37_RS14715	COG0567	Dehydrogenase, E1 component
HNS37_RS14720	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNS37_RS14725	COG0045	succinate-CoA ligase (ADP-forming) activity
HNS37_RS14730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HNS37_RS14735	COG1271	oxidase subunit
HNS37_RS14740	COG1294	oxidase, subunit
HNS37_RS14745	COG4890	Cyd operon protein YbgT
HNS37_RS14750	COG3790	cyd operon protein YbgE
HNS37_RS14755	COG0583	DNA-binding transcription factor activity
HNS37_RS14760	COG0477	Major facilitator Superfamily
HNS37_RS14770	COG0824	Thioesterase
HNS37_RS14775	COG0811	peptide transport
HNS37_RS14780	COG0848	biopolymer transport protein
HNS37_RS14785	COG3064	Membrane
HNS37_RS14790	COG0823	Involved in the tonB-independent uptake of proteins
HNS37_RS14795	COG2885	chlorophyll binding
HNS37_RS14800	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HNS37_RS14825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HNS37_RS14830	COG0588	phosphoglycerate mutase activity
HNS37_RS14835	COG1119	ATPase activity
HNS37_RS14875	COG3585	molybdate ion transport
HNS37_RS14875	COG2005	Transcriptional regulator
HNS37_RS14885	COG0725	ABC transporter, periplasmic molybdate-binding protein
HNS37_RS14890	COG4149	molybdate abc transporter
HNS37_RS14895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HNS37_RS14900	COG0561	phosphatase activity
HNS37_RS14905	COG2706	6-phosphogluconolactonase activity
HNS37_RS14910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HNS37_RS14915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HNS37_RS14920	COG0156	8-amino-7-oxononanoate synthase activity
HNS37_RS14925	COG2226	methyltransferase
HNS37_RS14935	COG0556	nucleotide-excision repair
HNS37_RS14945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HNS37_RS14950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HNS37_RS14955	COG0315	cyclic pyranopterin monophosphate synthase activity
HNS37_RS14960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HNS37_RS14965	COG0314	molybdopterin synthase activity
HNS37_RS14970	COG0670	Belongs to the BI1 family
HNS37_RS14985	COG0842	Transport permease protein
HNS37_RS14990	COG0842	Transport permease protein
HNS37_RS14995	COG1131	(ABC) transporter
HNS37_RS15005	COG1309	transcriptional regulator
HNS37_RS15010	COG0513	Belongs to the DEAD box helicase family
HNS37_RS15015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HNS37_RS15025	COG2897	thiosulfate sulfurtransferase activity
HNS37_RS15035	COG3069	C4-dicarboxylate transmembrane transporter activity
HNS37_RS15050	COG2079	MmgE PrpD family protein
HNS37_RS15055	COG0583	DNA-binding transcription factor activity
HNS37_RS15060	COG1199	ATP-dependent helicase activity
HNS37_RS15090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HNS37_RS15100	COG0477	Major facilitator Superfamily
HNS37_RS15105	COG0302	gtp cyclohydrolase
HNS37_RS15110	COG2311	Membrane
HNS37_RS15115	COG2949	membrane
HNS37_RS15120	COG0281	malic enzyme
HNS37_RS15125	COG0295	cytidine deaminase activity
HNS37_RS15130	COG1346	cytolysis
HNS37_RS15135	COG1380	Effector of murein hydrolase LrgA
HNS37_RS15140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNS37_RS15140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNS37_RS15145	COG0489	protein tyrosine kinase activity
HNS37_RS15150	COG0572	uridine kinase
HNS37_RS15155	COG0717	Belongs to the dCTP deaminase family
HNS37_RS15160	COG2982	Protein involved in outer membrane biogenesis
HNS37_RS15165	COG3069	C4-dicarboxylate transmembrane transporter activity
HNS37_RS15170	COG1253	flavin adenine dinucleotide binding
HNS37_RS15175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HNS37_RS15180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HNS37_RS15185	COG1454	alcohol dehydrogenase
HNS37_RS15190	COG0140	phosphoribosyl-ATP diphosphatase activity
HNS37_RS15190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HNS37_RS15195	COG0107	imidazoleglycerol-phosphate synthase activity
HNS37_RS15200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HNS37_RS15205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HNS37_RS15210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HNS37_RS15210	COG0131	Imidazoleglycerol-phosphate dehydratase
HNS37_RS15220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HNS37_RS15225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HNS37_RS15230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNS37_RS15235	COG0625	glutathione transferase activity
HNS37_RS15240	COG1686	Belongs to the peptidase S11 family
HNS37_RS15245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HNS37_RS15250	COG1760	l-serine dehydratase
HNS37_RS15255	COG0814	amino acid
HNS37_RS15260	COG0671	phosphoesterase, PA-phosphatase related
HNS37_RS15265	COG0432	Pfam Uncharacterised protein family UPF0047
HNS37_RS15270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HNS37_RS15285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HNS37_RS15290	COG4160	amino acid transport
HNS37_RS15295	COG4215	(ABC) transporter
HNS37_RS15300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HNS37_RS15305	COG1126	abc transporter atp-binding protein
HNS37_RS15310	COG0702	epimerase
HNS37_RS15315	COG2431	L-lysine efflux transmembrane transporter activity
HNS37_RS15320	COG3593	DNA synthesis involved in DNA repair
HNS37_RS15325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNS37_RS15330	COG1136	(ABC) transporter
HNS37_RS15330	COG0577	efflux transmembrane transporter activity
HNS37_RS15335	COG1278	Cold shock
HNS37_RS15340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HNS37_RS15345	COG0542	response to heat
HNS37_RS15350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HNS37_RS15355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HNS37_RS15360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HNS37_RS15370	COG0492	ferredoxin-NADP+ reductase activity
HNS37_RS15380	COG3107	peptidoglycan biosynthetic process
HNS37_RS15380	COG1674	ftsk spoiiie
HNS37_RS15385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HNS37_RS15390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HNS37_RS15395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HNS37_RS15405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HNS37_RS15415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HNS37_RS15420	COG1882	Formate acetyltransferase
HNS37_RS15425	COG2116	formate transmembrane transporter activity
HNS37_RS15430	COG1944	ATP diphosphatase activity
HNS37_RS15435	COG0252	asparaginase activity
HNS37_RS15450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HNS37_RS15455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HNS37_RS15460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HNS37_RS15465	COG0539	negative regulation of cytoplasmic translation
HNS37_RS15470	COG0776	regulation of translation
HNS37_RS15475	COG2333	competence protein COMEC
HNS37_RS15475	COG0658	competence protein
HNS37_RS15480	COG1132	(ABC) transporter
HNS37_RS15485	COG1663	tetraacyldisaccharide 4'-kinase activity
HNS37_RS15495	COG2835	tetraacyldisaccharide 4'-kinase activity
HNS37_RS15500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HNS37_RS15505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HNS37_RS15510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HNS37_RS15515	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HNS37_RS15520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HNS37_RS15525	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HNS37_RS15535	COG3700	Belongs to the class B bacterial acid phosphatase family
HNS37_RS15540	COG2989	Protein conserved in bacteria
HNS37_RS15545	COG3108	Peptidase M15
HNS37_RS15550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNS37_RS15555	COG3157	Type VI secretion system effector, Hcp
HNS37_RS15645	COG3501	Rhs element vgr protein
HNS37_RS15670	COG3209	COG3209 Rhs family protein
HNS37_RS15785	COG1448	Aminotransferase
HNS37_RS15790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HNS37_RS15795	COG0017	Asparaginyl-tRNA synthetase
HNS37_RS15805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HNS37_RS15810	COG0308	aminopeptidase N
HNS37_RS15815	COG0167	dihydroorotate dehydrogenase activity
HNS37_RS15825	COG0633	Ferredoxin
HNS37_RS15825	COG3217	Mosc domain protein beta barrel domain protein
HNS37_RS15830	COG0116	Belongs to the methyltransferase superfamily
HNS37_RS15830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HNS37_RS15835	COG0488	(ABC) transporter
HNS37_RS15840	COG2995	paraquat-inducible protein a
HNS37_RS15845	COG3008	intermembrane lipid transfer
HNS37_RS15845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HNS37_RS15850	COG3009	Protein conserved in bacteria
HNS37_RS15860	COG3130	regulation of translation
HNS37_RS15865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HNS37_RS15870	COG1067	ATP-dependent peptidase activity
HNS37_RS15875	COG3120	sequence-specific DNA binding
HNS37_RS15880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HNS37_RS15880	COG2885	chlorophyll binding
HNS37_RS15890	COG3070	regulator of competence-specific genes
HNS37_RS15895	COG1289	transmembrane transporter activity
HNS37_RS15900	COG0210	DNA helicase
HNS37_RS15905	COG1803	Methylglyoxal synthase
HNS37_RS15910	COG1832	CoA-binding protein
HNS37_RS15915	COG3785	DNA binding
HNS37_RS15920	COG1254	Belongs to the acylphosphatase family
HNS37_RS15925	COG2920	part of a sulfur-relay system
HNS37_RS15945	COG3615	Tellurite resistance protein tehB
HNS37_RS15960	COG0583	DNA-binding transcription factor activity
HNS37_RS15965	COG0656	L-ascorbic acid biosynthetic process
HNS37_RS15975	COG2207	Transcriptional regulator
HNS37_RS15975	COG3708	Transcriptional regulator
HNS37_RS15990	COG1278	Cold shock
HNS37_RS15995	COG1560	Kdo2-lipid A biosynthetic process
HNS37_RS16020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HNS37_RS16120	COG1802	Transcriptional regulator
HNS37_RS16120	COG4626	Terminase
HNS37_RS16125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HNS37_RS16130	COG0305	Participates in initiation and elongation during chromosome replication
HNS37_RS16175	COG3772	lysozyme
HNS37_RS16210	COG2369	cell adhesion
HNS37_RS16315	COG0438	transferase activity, transferring glycosyl groups
HNS37_RS16330	COG3083	sulfuric ester hydrolase activity
HNS37_RS16335	COG3082	Protein of unknown function (DUF1414)
HNS37_RS16340	COG3081	Nucleoid-associated protein
HNS37_RS16345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HNS37_RS16350	COG1061	Type III restriction enzyme res subunit
HNS37_RS16355	COG1187	pseudouridine synthase activity
HNS37_RS16360	COG2814	Major facilitator Superfamily
HNS37_RS16370	COG0791	NLP P60 protein
HNS37_RS16375	COG0671	phosphoesterase, PA-phosphatase related
HNS37_RS16390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HNS37_RS16400	COG0494	nUDIX hydrolase
HNS37_RS16405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HNS37_RS16410	COG2855	membrane
HNS37_RS16415	COG0583	DNA-binding transcription factor activity
HNS37_RS16420	COG0833	amino acid
HNS37_RS16425	COG4771	TonB-dependent receptor
HNS37_RS16430	COG0531	amino acid
HNS37_RS16440	COG3961	Belongs to the TPP enzyme family
HNS37_RS16445	COG0583	DNA-binding transcription factor activity
HNS37_RS16450	COG0277	FAD linked oxidase domain protein
HNS37_RS16455	COG2925	Exonuclease
HNS37_RS16460	COG2211	Major facilitator Superfamily
HNS37_RS16465	COG2926	Belongs to the UPF0265 family
HNS37_RS16470	COG1530	ribonuclease E activity
HNS37_RS16475	COG0564	pseudouridine synthase activity
HNS37_RS16485	COG0424	maF-like protein
HNS37_RS16490	COG1399	metal-binding, possibly nucleic acid-binding protein
HNS37_RS16495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HNS37_RS16500	COG0416	fatty acid biosynthetic process
HNS37_RS16505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNS37_RS16520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HNS37_RS16525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HNS37_RS16530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HNS37_RS16535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HNS37_RS16540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HNS37_RS16545	COG0470	DNA polymerase III
HNS37_RS16550	COG0084	hydrolase, TatD family'
HNS37_RS16555	COG0537	adenosine 5'-monophosphoramidase activity
HNS37_RS16560	COG5633	Lipoprotein
HNS37_RS16565	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HNS37_RS16575	COG1472	Belongs to the glycosyl hydrolase 3 family
HNS37_RS16585	COG1252	NADH dehydrogenase
HNS37_RS16590	COG3134	Outer membrane lipoprotein
HNS37_RS16595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HNS37_RS16600	COG4591	ABC-type transport system involved in lipoprotein release permease component
HNS37_RS16610	COG4591	ABC-type transport system involved in lipoprotein release permease component
HNS37_RS16625	COG2850	peptidyl-arginine hydroxylation
HNS37_RS16630	COG2205	protein histidine kinase activity
HNS37_RS16635	COG0745	RESPONSE REGULATOR receiver
HNS37_RS16640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HNS37_RS16645	COG2915	High frequency lysogenization protein hflD homolog
HNS37_RS16650	COG0482	sulfurtransferase activity
HNS37_RS16660	COG1187	pseudouridine synthase activity
HNS37_RS16665	COG0538	isocitrate dehydrogenase activity
HNS37_RS16670	COG0582	viral genome integration into host DNA
HNS37_RS16680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HNS37_RS16695	COG0556	nucleotide-excision repair
HNS37_RS16725	COG1846	Transcriptional regulator
HNS37_RS16735	COG1403	HNH endonuclease
HNS37_RS16745	COG1278	Cold shock
HNS37_RS16750	COG0071	Belongs to the small heat shock protein (HSP20) family
HNS37_RS16775	COG3772	lysozyme
HNS37_RS16810	COG4626	Terminase
HNS37_RS16810	COG1802	Transcriptional regulator
HNS37_RS16915	COG0538	isocitrate dehydrogenase activity
HNS37_RS16965	COG1278	Cold shock
HNS37_RS16970	COG0071	Belongs to the small heat shock protein (HSP20) family
HNS37_RS16980	COG1733	regulation of RNA biosynthetic process
HNS37_RS16985	COG0702	epimerase
HNS37_RS16995	COG0572	uridine kinase
HNS37_RS17005	COG1475	DNA binding
HNS37_RS17010	COG3969	phosphoadenosine phosphosulfate
HNS37_RS17015	COG0500	methyltransferase
HNS37_RS17030	COG3272	Protein of unknown function (DUF1722)
HNS37_RS17040	COG2841	Protein conserved in bacteria
HNS37_RS17070	COG0024	Methionine aminopeptidase
HNS37_RS17080	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HNS37_RS17085	COG1598	PFAM Uncharacterised protein family UPF0150
HNS37_RS17090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HNS37_RS17110	COG1528	Iron-storage protein
HNS37_RS17115	COG2372	response to copper ion
HNS37_RS17120	COG1276	copper resistance
HNS37_RS17135	COG3008	intermembrane lipid transfer
HNS37_RS17140	COG2995	paraquat-inducible protein a
HNS37_RS17145	COG1956	GAF domain-containing protein
HNS37_RS17150	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HNS37_RS17165	COG0501	Belongs to the peptidase M48B family
HNS37_RS17175	COG1988	membrane-bound metal-dependent
HNS37_RS17180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNS37_RS17190	COG3001	Fructosamine kinase
HNS37_RS17195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HNS37_RS17200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HNS37_RS17205	COG1121	(ABC) transporter
HNS37_RS17210	COG0803	Belongs to the bacterial solute-binding protein 9 family
HNS37_RS17230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNS37_RS17245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HNS37_RS17250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HNS37_RS17255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HNS37_RS17260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HNS37_RS17270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HNS37_RS17275	COG0072	phenylalanine-tRNA ligase activity
HNS37_RS17275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNS37_RS17280	COG0776	regulation of translation
HNS37_RS17285	COG4139	cobalamin transport
HNS37_RS17290	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HNS37_RS17295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HNS37_RS17300	COG0463	Glycosyl transferase, family 2
HNS37_RS17305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNS37_RS17305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HNS37_RS17310	COG0726	polysaccharide deacetylase
HNS37_RS17315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HNS37_RS17320	COG2076	Multidrug Resistance protein
HNS37_RS17325	COG2076	Multidrug Resistance protein
HNS37_RS17330	COG0791	NLP P60 protein
HNS37_RS17335	COG0095	Lipoate-protein ligase
HNS37_RS17340	COG2207	Transcriptional regulator
HNS37_RS17345	COG0579	oxidoreductase
HNS37_RS17350	COG2186	Transcriptional regulator
HNS37_RS17365	COG0586	Pfam SNARE associated Golgi protein
HNS37_RS17420	COG0012	GTP binding
HNS37_RS17425	COG0193	aminoacyl-tRNA hydrolase activity
HNS37_RS17435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HNS37_RS17440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HNS37_RS17445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HNS37_RS17450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HNS37_RS17455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HNS37_RS17465	COG2912	Transglutaminase-like superfamily
HNS37_RS17470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HNS37_RS17475	COG1242	4 iron, 4 sulfur cluster binding
HNS37_RS17485	COG0659	secondary active sulfate transmembrane transporter activity
HNS37_RS17495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNS37_RS17510	COG3381	protein complex oligomerization
HNS37_RS17520	COG0477	Major facilitator Superfamily
HNS37_RS17525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNS37_RS17530	COG0728	peptidoglycan biosynthetic process
HNS37_RS17540	COG0018	arginyl-trna synthetase
HNS37_RS17545	COG3102	Protein conserved in bacteria
HNS37_RS17550	COG3142	Participates in the control of copper homeostasis
HNS37_RS17560	COG0488	(ABC) transporter
HNS37_RS17565	COG0500	methyltransferase
HNS37_RS17570	COG2226	methyltransferase
HNS37_RS17575	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HNS37_RS17580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HNS37_RS17585	COG0494	nUDIX hydrolase
HNS37_RS17590	COG0217	transcriptional regulatory protein
HNS37_RS17595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HNS37_RS17600	COG0632	four-way junction helicase activity
HNS37_RS17605	COG2255	four-way junction helicase activity
HNS37_RS17610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HNS37_RS17615	COG1121	(ABC) transporter
HNS37_RS17620	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HNS37_RS17625	COG0739	heme binding
HNS37_RS17630	COG1560	Kdo2-lipid A biosynthetic process
HNS37_RS17635	COG0469	pyruvate kinase activity
HNS37_RS17640	COG1737	Transcriptional regulator
HNS37_RS17645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HNS37_RS17650	COG2076	Multidrug Resistance protein
HNS37_RS17655	COG2076	Multidrug Resistance protein
HNS37_RS17660	COG0702	epimerase
HNS37_RS17665	COG0251	oxidation-reduction process
HNS37_RS17670	COG1199	ATP-dependent helicase activity
HNS37_RS17680	COG3065	identical protein binding
HNS37_RS17685	COG0318	PFAM AMP-dependent synthetase and ligase
HNS37_RS17690	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HNS37_RS17695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HNS37_RS17700	COG2894	cell division
HNS37_RS17705	COG0850	regulation of cytokinetic process
HNS37_RS17710	COG3100	YcgL domain-containing protein
HNS37_RS17715	COG2951	lytic endotransglycosylase activity
HNS37_RS17720	COG0179	Fumarylacetoacetate (FAA) hydrolase
HNS37_RS17725	COG2983	Belongs to the UPF0260 family
HNS37_RS17730	COG0390	transport system, permease component
HNS37_RS17735	COG4619	ABC transporter
HNS37_RS17745	COG2207	Transcriptional regulator
HNS37_RS17745	COG3708	Transcriptional regulator
HNS37_RS17755	COG0840	transmembrane signaling receptor activity
HNS37_RS17760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HNS37_RS17765	COG2911	Protein conserved in bacteria
HNS37_RS17775	COG3784	Protein of unknown function (DUF1318)
HNS37_RS17790	COG3188	usher protein
HNS37_RS17805	COG2801	Transposase and inactivated derivatives
HNS37_RS17830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HNS37_RS17835	COG1643	Atp-dependent helicase
HNS37_RS17850	COG3188	usher protein
HNS37_RS17865	COG0531	amino acid
HNS37_RS17875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HNS37_RS17880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HNS37_RS17885	COG0589	response to stress
HNS37_RS17890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HNS37_RS17895	COG0243	molybdopterin cofactor binding
HNS37_RS17900	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS17915	COG0604	alcohol dehydrogenase
HNS37_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
HNS37_RS17915	COG3321	synthase
HNS37_RS17925	COG1695	Transcriptional regulator
HNS37_RS17945	COG3634	alkyl hydroperoxide reductase activity
HNS37_RS17990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HNS37_RS17995	COG4974	Belongs to the 'phage' integrase family
HNS37_RS18005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNS37_RS18010	COG1129	ABC transporter
HNS37_RS18010	COG0842	Transport permease protein
HNS37_RS18015	COG0842	Transport permease protein
HNS37_RS18020	COG0745	RESPONSE REGULATOR receiver
HNS37_RS18025	COG2205	protein histidine kinase activity
HNS37_RS18030	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HNS37_RS18035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HNS37_RS18040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HNS37_RS18045	COG0666	response to abiotic stimulus
HNS37_RS18050	COG0590	tRNA wobble adenosine to inosine editing
HNS37_RS18055	COG3381	protein complex oligomerization
HNS37_RS18060	COG3302	dmso reductase anchor subunit
HNS37_RS18065	COG0437	4 iron, 4 sulfur cluster binding
HNS37_RS18070	COG0243	molybdopterin cofactor binding
HNS37_RS18075	COG1349	DNA-binding transcription factor activity
HNS37_RS18095	COG2376	Dihydroxyacetone kinase
HNS37_RS18105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HNS37_RS18115	COG0251	oxidation-reduction process