locus-tag	class	description
HPT03_RS00015	COG1454	alcohol dehydrogenase
HPT03_RS00015	COG1012	belongs to the aldehyde dehydrogenase family
HPT03_RS00020	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HPT03_RS00030	COG1882	Formate acetyltransferase
HPT03_RS00035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPT03_RS00045	COG4869	propanediol catabolic process
HPT03_RS00070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPT03_RS00085	COG0789	Transcriptional regulator
HPT03_RS00125	COG2207	Transcriptional regulator
HPT03_RS00170	COG4790	Type iii secretion
HPT03_RS00215	COG0157	Belongs to the NadC ModD family
HPT03_RS00220	COG0500	methyltransferase
HPT03_RS00225	COG1120	ATPase activity
HPT03_RS00240	COG1609	Transcriptional regulator
HPT03_RS00245	COG3265	gluconokinase activity
HPT03_RS00250	COG2610	gluconate transmembrane transporter activity
HPT03_RS00275	COG2992	FlgJ-related protein
HPT03_RS00295	COG2137	regulation of response to DNA damage stimulus
HPT03_RS00300	COG3397	chitin binding
HPT03_RS00320	COG1024	Enoyl-CoA hydratase
HPT03_RS00325	COG0318	PFAM AMP-dependent synthetase and ligase
HPT03_RS00330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPT03_RS00335	COG1960	acyl-CoA dehydrogenase activity
HPT03_RS00355	COG0644	oxidoreductase
HPT03_RS00360	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPT03_RS00365	COG2271	Major facilitator Superfamily
HPT03_RS00370	COG0318	PFAM AMP-dependent synthetase and ligase
HPT03_RS00380	COG1924	4 iron, 4 sulfur cluster binding
HPT03_RS00395	COG2610	gluconate transmembrane transporter activity
HPT03_RS00400	COG1960	acyl-CoA dehydrogenase activity
HPT03_RS00405	COG2086	electron transfer activity
HPT03_RS00410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPT03_RS00415	COG0644	oxidoreductase
HPT03_RS00420	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPT03_RS00425	COG4977	sequence-specific DNA binding
HPT03_RS00430	COG2255	four-way junction helicase activity
HPT03_RS00445	COG1704	LemA family
HPT03_RS00450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPT03_RS00470	COG1309	transcriptional regulator
HPT03_RS00475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPT03_RS00490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPT03_RS00495	COG0459	protein refolding
HPT03_RS00510	COG0702	epimerase
HPT03_RS00545	COG3188	usher protein
HPT03_RS00560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPT03_RS00565	COG0698	ribose 5-phosphate isomerase
HPT03_RS00570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPT03_RS00575	COG0651	ATP synthesis coupled electron transport
HPT03_RS00580	COG0650	Formate hydrogenlyase subunit 4
HPT03_RS00585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPT03_RS00590	COG4237	Hydrogenase 4 membrane
HPT03_RS00595	COG0651	ATP synthesis coupled electron transport
HPT03_RS00600	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HPT03_RS00600	COG3261	NADH dehydrogenase
HPT03_RS00605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPT03_RS00610	COG3260	NADH ubiquinone oxidoreductase 20
HPT03_RS00620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPT03_RS00625	COG1216	Glycosyl transferase, family 2
HPT03_RS00640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPT03_RS00660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPT03_RS00665	COG1328	CTP reductase activity
HPT03_RS00670	COG3726	membrane protein affecting hemolysin expression
HPT03_RS00675	COG0560	Phosphoserine phosphatase
HPT03_RS00695	COG2382	esterase
HPT03_RS00705	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPT03_RS00720	COG2813	Specifically methylates the guanine in position
HPT03_RS00750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPT03_RS00755	COG3620	sequence-specific DNA binding
HPT03_RS00760	COG3550	peptidyl-serine autophosphorylation
HPT03_RS00795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPT03_RS00845	COG1196	nuclear chromosome segregation
HPT03_RS00915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPT03_RS00930	COG0681	Belongs to the peptidase S26 family
HPT03_RS00955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPT03_RS00965	COG2356	endonuclease I
HPT03_RS00980	COG0629	single-stranded DNA binding
HPT03_RS01000	COG0714	Associated with various cellular activities
HPT03_RS01025	COG2003	Belongs to the UPF0758 family
HPT03_RS01045	COG1401	restriction endodeoxyribonuclease activity
HPT03_RS01110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPT03_RS01120	COG4667	esterase of the alpha-beta hydrolase superfamily
HPT03_RS01125	COG0084	hydrolase, TatD family'
HPT03_RS01130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPT03_RS01135	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPT03_RS01140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPT03_RS01145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPT03_RS01150	COG0813	purine-nucleoside phosphorylase activity
HPT03_RS01155	COG2851	Citrate transporter
HPT03_RS01165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPT03_RS01170	COG0469	pyruvate kinase activity
HPT03_RS01175	COG2271	Major facilitator Superfamily
HPT03_RS01185	COG4191	Histidine kinase
HPT03_RS01200	COG3188	usher protein
HPT03_RS01205	COG3121	Chaperone
HPT03_RS01210	COG3539	Fimbrial protein
HPT03_RS01230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPT03_RS01230	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HPT03_RS01230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPT03_RS01235	COG1461	Dihydroxyacetone kinase
HPT03_RS01240	COG2376	Dihydroxyacetone kinase
HPT03_RS01290	COG1358	cellular component organization or biogenesis
HPT03_RS01340	COG0840	transmembrane signaling receptor activity
HPT03_RS01345	COG0840	transmembrane signaling receptor activity
HPT03_RS01350	COG0583	DNA-binding transcription factor activity
HPT03_RS01355	COG0243	molybdopterin cofactor binding
HPT03_RS01360	COG1271	oxidase subunit
HPT03_RS01365	COG1294	oxidase, subunit
HPT03_RS01375	COG3781	membrane
HPT03_RS01400	COG0358	DNA primase activity
HPT03_RS01405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPT03_RS01410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPT03_RS01415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPT03_RS01435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPT03_RS01440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPT03_RS01445	COG0617	tRNA 3'-terminal CCA addition
HPT03_RS01450	COG4991	sh3 domain protein
HPT03_RS01455	COG3025	triphosphatase activity
HPT03_RS01460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPT03_RS01465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPT03_RS01465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPT03_RS01485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPT03_RS01490	COG3384	dioxygenase
HPT03_RS01495	COG0754	glutathionylspermidine amidase activity
HPT03_RS01500	COG5463	Belongs to the UPF0441 family
HPT03_RS01505	COG1538	Outer membrane efflux protein
HPT03_RS01510	COG0494	nUDIX hydrolase
HPT03_RS01515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPT03_RS01520	COG3150	esterase
HPT03_RS01525	COG0187	DNA topoisomerase II activity
HPT03_RS01530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPT03_RS01535	COG0204	Acyl-transferase
HPT03_RS01540	COG2132	Multicopper oxidase
HPT03_RS01560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPT03_RS01565	COG2967	ApaG domain
HPT03_RS01570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPT03_RS01575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPT03_RS01580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPT03_RS01585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPT03_RS01590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPT03_RS01595	COG0564	pseudouridine synthase activity
HPT03_RS01600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPT03_RS01605	COG0417	DNA replication proofreading
HPT03_RS01615	COG3311	Transcriptional regulator
HPT03_RS01620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPT03_RS01625	COG1178	ABC-type Fe3 transport system permease component
HPT03_RS01630	COG4143	(ABC) transporter
HPT03_RS01635	COG0494	nUDIX hydrolase
HPT03_RS01645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPT03_RS01685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPT03_RS01690	COG1025	Belongs to the peptidase M16 family
HPT03_RS01695	COG1074	ATP-dependent DNA helicase activity
HPT03_RS01700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPT03_RS01705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPT03_RS01705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPT03_RS01710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPT03_RS01730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPT03_RS01735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPT03_RS01740	COG2166	iron-sulfur cluster assembly
HPT03_RS01745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPT03_RS01750	COG0583	DNA-binding transcription factor activity
HPT03_RS01755	COG2363	Small membrane protein
HPT03_RS01760	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HPT03_RS01765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPT03_RS01770	COG1611	Belongs to the LOG family
HPT03_RS01775	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPT03_RS01775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPT03_RS01785	COG3098	single-species biofilm formation
HPT03_RS01795	COG1263	PTS System
HPT03_RS01795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS01805	COG0716	FMN binding
HPT03_RS01815	COG2171	N-acyltransferase activity
HPT03_RS01820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPT03_RS01830	COG0052	Belongs to the universal ribosomal protein uS2 family
HPT03_RS01835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPT03_RS01840	COG0528	UMP kinase activity
HPT03_RS01845	COG0233	cytoplasmic translational termination
HPT03_RS01850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPT03_RS01855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPT03_RS01860	COG0575	Belongs to the CDS family
HPT03_RS01880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPT03_RS01885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPT03_RS01890	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPT03_RS01895	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPT03_RS01900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPT03_RS01910	COG0825	malonyl-CoA metabolic process
HPT03_RS01920	COG0037	tRNA processing
HPT03_RS01925	COG4568	rho-dependent transcription termination
HPT03_RS01930	COG3015	lipoprotein NlpE involved in copper resistance
HPT03_RS01935	COG0442	prolyl-tRNA aminoacylation
HPT03_RS01940	COG1720	tRNA m6t6A37 methyltransferase activity
HPT03_RS01950	COG1464	Belongs to the NlpA lipoprotein family
HPT03_RS01955	COG2011	ABC-type metal ion transport system permease component
HPT03_RS01960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPT03_RS01965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPT03_RS02020	COG0602	queuosine metabolic process
HPT03_RS02025	COG0720	synthase
HPT03_RS02030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPT03_RS02035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPT03_RS02040	COG0175	sulfate reduction
HPT03_RS02045	COG1648	precorrin-2 dehydrogenase activity
HPT03_RS02045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPT03_RS02050	COG0175	sulfate reduction
HPT03_RS02055	COG2895	sulfate adenylyltransferase (ATP) activity
HPT03_RS02070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPT03_RS02075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPT03_RS02080	COG0585	pseudouridine synthase activity
HPT03_RS02085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPT03_RS02090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPT03_RS02095	COG4942	peptidase
HPT03_RS02095	COG1388	LysM domain
HPT03_RS02105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPT03_RS02125	COG3711	transcriptional antiterminator
HPT03_RS02130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS02130	COG2190	(PTS) system
HPT03_RS02130	COG1263	PTS System
HPT03_RS02135	COG0613	PHP domain protein
HPT03_RS02230	COG0471	metal ion transport
HPT03_RS02245	COG1335	isochorismatase
HPT03_RS02250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPT03_RS02255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPT03_RS02265	COG0549	Belongs to the carbamate kinase family
HPT03_RS02275	COG0583	DNA-binding transcription factor activity
HPT03_RS02285	COG4589	Belongs to the CDS family
HPT03_RS02300	COG4566	intracellular signal transduction
HPT03_RS02320	COG2962	Rard protein
HPT03_RS02325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPT03_RS02330	COG0326	Molecular chaperone. Has ATPase activity
HPT03_RS02335	COG0563	adenylate kinase activity
HPT03_RS02340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPT03_RS02345	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPT03_RS02350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPT03_RS02355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPT03_RS02355	COG4651	solute:proton antiporter activity
HPT03_RS02365	COG0675	Transposase, IS605 OrfB family
HPT03_RS02370	COG0737	Belongs to the 5'-nucleotidase family
HPT03_RS02380	COG3735	TraB family
HPT03_RS02395	COG0789	Transcriptional regulator
HPT03_RS02405	COG0330	HflC and HflK could
HPT03_RS02410	COG3118	belongs to the thioredoxin family
HPT03_RS02415	COG0300	oxidoreductase activity
HPT03_RS02420	COG2755	lipolytic protein G-D-S-L family
HPT03_RS02425	COG4181	ATPase activity
HPT03_RS02430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPT03_RS02435	COG0668	transmembrane transport
HPT03_RS02445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPT03_RS02450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPT03_RS02455	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPT03_RS02460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPT03_RS02465	COG0215	cysteine-tRNA ligase activity
HPT03_RS02470	COG1105	Belongs to the carbohydrate kinase PfkB family
HPT03_RS02475	COG2501	S4 domain
HPT03_RS02480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPT03_RS02550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPT03_RS02560	COG0640	Transcriptional regulator
HPT03_RS02565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPT03_RS02570	COG0384	phenazine biosynthesis protein PhzF
HPT03_RS02585	COG0800	Aldolase
HPT03_RS02590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPT03_RS02605	COG3119	arylsulfatase activity
HPT03_RS02610	COG0641	radical SAM
HPT03_RS02615	COG1349	DNA-binding transcription factor activity
HPT03_RS02625	COG2222	sugar isomerase
HPT03_RS02630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS02635	COG3715	PTS system
HPT03_RS02640	COG3716	PTS system mannose fructose sorbose family IID component
HPT03_RS02645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPT03_RS02645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS02650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPT03_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS02690	COG3119	arylsulfatase activity
HPT03_RS02700	COG5295	Hep Hag repeat protein
HPT03_RS02710	COG3038	cytochrome b561
HPT03_RS02715	COG2353	YceI-like domain
HPT03_RS02720	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPT03_RS02725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPT03_RS02740	COG1115	amino acid carrier protein
HPT03_RS02750	COG1151	hydroxylamine reductase activity
HPT03_RS02755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPT03_RS02765	COG2239	Acts as a magnesium transporter
HPT03_RS02770	COG3091	SprT-like family
HPT03_RS02775	COG0640	Transcriptional regulator
HPT03_RS02790	COG0457	Tetratricopeptide repeat
HPT03_RS02790	COG3118	belongs to the thioredoxin family
HPT03_RS02795	COG1215	transferase activity, transferring glycosyl groups
HPT03_RS02805	COG1192	Involved in chromosome partitioning
HPT03_RS02820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPT03_RS02825	COG1166	arginine decarboxylase activity
HPT03_RS02830	COG0010	Belongs to the arginase family
HPT03_RS02845	COG3066	DNA modification
HPT03_RS02850	COG4533	DNA binding
HPT03_RS02855	COG0066	3-isopropylmalate dehydratase activity
HPT03_RS02860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPT03_RS02865	COG0473	3-isopropylmalate dehydrogenase activity
HPT03_RS02870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPT03_RS02880	COG1022	Amp-dependent synthetase and ligase
HPT03_RS02890	COG2001	Belongs to the MraZ family
HPT03_RS02895	COG0275	rRNA processing
HPT03_RS02905	COG0768	penicillin binding
HPT03_RS02910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPT03_RS02915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPT03_RS02920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPT03_RS02930	COG0772	Belongs to the SEDS family
HPT03_RS02935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPT03_RS02940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPT03_RS02950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPT03_RS02955	COG0849	cell division
HPT03_RS02965	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPT03_RS02980	COG0653	protein targeting
HPT03_RS03000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HPT03_RS03005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPT03_RS03010	COG0237	dephospho-CoA kinase activity
HPT03_RS03020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPT03_RS03025	COG4969	Belongs to the N-Me-Phe pilin family
HPT03_RS03030	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPT03_RS03035	COG2186	Transcriptional regulator
HPT03_RS03040	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPT03_RS03045	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPT03_RS03050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPT03_RS03055	COG1073	alpha beta
HPT03_RS03055	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPT03_RS03055	COG3064	Membrane
HPT03_RS03075	COG3112	Uncharacterised protein family (UPF0231)
HPT03_RS03085	COG1279	arginine transmembrane transporter activity
HPT03_RS03105	COG0583	DNA-binding transcription factor activity
HPT03_RS03110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPT03_RS03115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPT03_RS03125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPT03_RS03135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPT03_RS03145	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPT03_RS03150	COG3079	Belongs to the UPF0149 family
HPT03_RS03155	COG0006	proline dipeptidase activity
HPT03_RS03160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPT03_RS03165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPT03_RS03170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPT03_RS03175	COG0509	glycine decarboxylation via glycine cleavage system
HPT03_RS03180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPT03_RS03180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPT03_RS03190	COG0354	folic acid binding
HPT03_RS03195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPT03_RS03205	COG0716	FMN binding
HPT03_RS03215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPT03_RS03220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPT03_RS03230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPT03_RS03300	COG2841	Protein conserved in bacteria
HPT03_RS03305	COG4574	serine-type endopeptidase inhibitor activity
HPT03_RS03310	COG0589	response to stress
HPT03_RS03315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPT03_RS03325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPT03_RS03330	COG1085	galactose-1-phosphate uridylyltransferase
HPT03_RS03335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPT03_RS03340	COG2017	converts alpha-aldose to the beta-anomer
HPT03_RS03345	COG1609	Transcriptional regulator
HPT03_RS03355	COG4771	TonB-dependent receptor
HPT03_RS03360	COG2819	hydrolase of the alpha beta superfamily
HPT03_RS03370	COG3738	Protein conserved in bacteria
HPT03_RS03375	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPT03_RS03390	COG1556	Lactate utilization protein
HPT03_RS03395	COG1139	Iron-sulfur cluster binding protein
HPT03_RS03400	COG0247	lactate metabolic process
HPT03_RS03405	COG1620	l-lactate permease
HPT03_RS03410	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPT03_RS03425	COG0579	oxidoreductase
HPT03_RS03490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPT03_RS03495	COG0732	type I restriction modification DNA specificity domain
HPT03_RS03500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPT03_RS03520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPT03_RS03525	COG2867	negative regulation of translational initiation
HPT03_RS03530	COG2914	Belongs to the UPF0125 (RnfH) family
HPT03_RS03540	COG0497	DNA recombination
HPT03_RS03545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPT03_RS03550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPT03_RS03555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPT03_RS03560	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPT03_RS03565	COG0513	Belongs to the DEAD box helicase family
HPT03_RS03570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPT03_RS03575	COG1595	DNA-templated transcription, initiation
HPT03_RS03580	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HPT03_RS03585	COG3026	antisigma factor binding
HPT03_RS03590	COG3086	response to oxidative stress
HPT03_RS03595	COG0481	GTPase activity
HPT03_RS03600	COG0681	Belongs to the peptidase S26 family
HPT03_RS03605	COG0571	ribonuclease III activity
HPT03_RS03610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPT03_RS03615	COG1381	Involved in DNA repair and RecF pathway recombination
HPT03_RS03620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPT03_RS03625	COG0736	holo-[acyl-carrier-protein] synthase activity
HPT03_RS03630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPT03_RS03640	COG3539	Fimbrial protein
HPT03_RS03645	COG3539	Fimbrial protein
HPT03_RS03650	COG3121	Chaperone
HPT03_RS03655	COG3188	usher protein
HPT03_RS03660	COG3539	Fimbrial protein
HPT03_RS03665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPT03_RS03670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPT03_RS03670	COG0047	phosphoribosylformylglycinamidine synthase activity
HPT03_RS03675	COG2205	protein histidine kinase activity
HPT03_RS03680	COG3170	Tfp pilus assembly protein FimV
HPT03_RS03685	COG2204	response regulator
HPT03_RS03690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPT03_RS03690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPT03_RS03695	COG0347	Belongs to the P(II) protein family
HPT03_RS03705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPT03_RS03705	COG1017	nitric oxide dioxygenase activity
HPT03_RS03710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPT03_RS03715	COG2814	Major facilitator Superfamily
HPT03_RS03730	COG0483	inositol monophosphate 1-phosphatase activity
HPT03_RS03735	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HPT03_RS03740	COG1959	2 iron, 2 sulfur cluster binding
HPT03_RS03745	COG1104	cysteine desulfurase activity
HPT03_RS03750	COG0822	iron-sulfur transferase activity
HPT03_RS03755	COG0316	Belongs to the HesB IscA family
HPT03_RS03760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPT03_RS03765	COG0443	Heat shock 70 kDa protein
HPT03_RS03770	COG0633	Ferredoxin
HPT03_RS03775	COG2975	iron-sulfur cluster assembly
HPT03_RS03780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPT03_RS03790	COG2373	Large extracellular alpha-helical protein
HPT03_RS03795	COG4953	penicillin-binding protein 1C
HPT03_RS03800	COG0105	UTP biosynthetic process
HPT03_RS03805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPT03_RS03820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPT03_RS03825	COG0124	histidyl-tRNA synthetase
HPT03_RS03830	COG2976	Protein conserved in bacteria
HPT03_RS03835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPT03_RS03840	COG1160	GTP binding
HPT03_RS03850	COG0408	coproporphyrinogen oxidase activity
HPT03_RS03855	COG0456	acetyltransferase
HPT03_RS03865	COG2837	iron assimilation
HPT03_RS03875	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPT03_RS03880	COG4208	sulfate ABC transporter
HPT03_RS03885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPT03_RS03890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPT03_RS03895	COG2190	(PTS) system
HPT03_RS03905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPT03_RS03910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPT03_RS03920	COG3115	cell septum assembly
HPT03_RS03925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPT03_RS03930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPT03_RS03935	COG3530	Putative quorum-sensing-regulated virulence factor
HPT03_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS03960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPT03_RS04000	COG1396	sequence-specific DNA binding
HPT03_RS04090	COG3723	Recombinational DNA repair protein, rece pathway
HPT03_RS04095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPT03_RS04170	COG0305	Participates in initiation and elongation during chromosome replication
HPT03_RS04365	COG3620	sequence-specific DNA binding
HPT03_RS04415	COG3594	Acyltransferase
HPT03_RS04435	COG2067	long-chain fatty acid transport protein
HPT03_RS04440	COG3691	Protein conserved in bacteria
HPT03_RS04445	COG0183	Belongs to the thiolase family
HPT03_RS04450	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPT03_RS04450	COG1024	Enoyl-CoA hydratase
HPT03_RS04455	COG2062	phosphohistidine phosphatase, SixA
HPT03_RS04460	COG2840	Smr protein MutS2
HPT03_RS04465	COG0783	Belongs to the Dps family
HPT03_RS04475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPT03_RS04480	COG0730	response to heat
HPT03_RS04485	COG3101	peptidyl-lysine hydroxylation
HPT03_RS04505	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPT03_RS04505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPT03_RS04510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPT03_RS04515	COG0697	spore germination
HPT03_RS04520	COG2207	Transcriptional regulator
HPT03_RS04525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPT03_RS04530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPT03_RS04540	COG0586	Pfam SNARE associated Golgi protein
HPT03_RS04545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPT03_RS04550	COG0285	dihydrofolate synthase activity
HPT03_RS04555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPT03_RS04560	COG1286	toxin biosynthetic process
HPT03_RS04565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPT03_RS04570	COG0163	prenyltransferase activity
HPT03_RS04575	COG1090	epimerase
HPT03_RS04580	COG0625	glutathione transferase activity
HPT03_RS04585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HPT03_RS04595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPT03_RS04605	COG3037	sugar-specific permease SgaT UlaA
HPT03_RS04640	COG0280	phosphate acetyltransferase
HPT03_RS04640	COG0857	belongs to the CobB CobQ family
HPT03_RS04645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPT03_RS04650	COG3092	negative regulation of chromosome organization
HPT03_RS04655	COG3013	Belongs to the UPF0304 family
HPT03_RS04660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPT03_RS04665	COG0490	domain, Protein
HPT03_RS04665	COG0471	metal ion transport
HPT03_RS04670	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPT03_RS04675	COG0436	Aminotransferase
HPT03_RS04680	COG0583	DNA-binding transcription factor activity
HPT03_RS04685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPT03_RS04690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPT03_RS04695	COG0649	NAD binding
HPT03_RS04695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPT03_RS04705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HPT03_RS04715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPT03_RS04720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPT03_RS04725	COG0839	Belongs to the complex I subunit 6 family
HPT03_RS04730	COG0713	ATP synthesis coupled electron transport
HPT03_RS04735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPT03_RS04740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPT03_RS04745	COG1007	ATP synthesis coupled electron transport
HPT03_RS04750	COG3157	Type VI secretion system effector, Hcp
HPT03_RS04770	COG1169	isochorismate synthase
HPT03_RS04775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPT03_RS04780	COG0596	Alpha beta hydrolase
HPT03_RS04785	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPT03_RS04790	COG1441	menaquinone biosynthetic process
HPT03_RS04810	COG0814	amino acid
HPT03_RS04820	COG0633	Ferredoxin
HPT03_RS04825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPT03_RS04830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPT03_RS04835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPT03_RS04845	COG0784	Response regulator, receiver
HPT03_RS04845	COG2205	protein histidine kinase activity
HPT03_RS04850	COG2197	response regulator
HPT03_RS04855	COG0642	Histidine kinase
HPT03_RS04855	COG2198	Histidine kinase
HPT03_RS04995	COG3302	dmso reductase anchor subunit
HPT03_RS05000	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS05005	COG0243	molybdopterin cofactor binding
HPT03_RS05010	COG0668	transmembrane transport
HPT03_RS05015	COG3247	response to pH
HPT03_RS05025	COG1396	sequence-specific DNA binding
HPT03_RS05030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPT03_RS05055	COG1902	pentaerythritol trinitrate reductase activity
HPT03_RS05070	COG1607	acyl-coa hydrolase
HPT03_RS05080	COG3104	oligopeptide transport
HPT03_RS05085	COG2814	Major facilitator Superfamily
HPT03_RS05090	COG1560	Kdo2-lipid A biosynthetic process
HPT03_RS05130	COG0418	dihydroorotase activity
HPT03_RS05170	COG1285	pathogenesis
HPT03_RS05190	COG1360	Flagellar Motor Protein
HPT03_RS05195	COG0643	Histidine kinase
HPT03_RS05195	COG2198	Histidine kinase
HPT03_RS05200	COG0835	chemotaxis
HPT03_RS05205	COG0840	transmembrane signaling receptor activity
HPT03_RS05210	COG0840	transmembrane signaling receptor activity
HPT03_RS05220	COG2201	protein-glutamate methylesterase activity
HPT03_RS05225	COG0745	RESPONSE REGULATOR receiver
HPT03_RS05240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPT03_RS05250	COG3210	domain, Protein
HPT03_RS05270	COG1815	bacterial-type flagellum-dependent cell motility
HPT03_RS05275	COG1558	bacterial-type flagellum-dependent cell motility
HPT03_RS05300	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPT03_RS05305	COG1706	bacterial-type flagellum-dependent cell motility
HPT03_RS05315	COG1256	bacterial-type flagellum assembly
HPT03_RS05330	COG1987	bacterial-type flagellum assembly
HPT03_RS05335	COG1338	Plays a role in the flagellum-specific transport system
HPT03_RS05355	COG1580	Controls the rotational direction of flagella during chemotaxis
HPT03_RS05365	COG2882	bacterial-type flagellum organization
HPT03_RS05370	COG1157	protein secretion by the type III secretion system
HPT03_RS05385	COG1766	The M ring may be actively involved in energy transduction
HPT03_RS05390	COG1677	Flagellar hook-basal body complex protein FliE
HPT03_RS05440	COG1191	sigma factor activity
HPT03_RS05450	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPT03_RS05450	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPT03_RS05450	COG0506	proline dehydrogenase activity
HPT03_RS05455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPT03_RS05465	COG1113	amino acid transport
HPT03_RS05480	COG0589	response to stress
HPT03_RS05490	COG2226	methyltransferase
HPT03_RS05495	COG1971	Probably functions as a manganese efflux pump
HPT03_RS05500	COG1760	l-serine dehydratase
HPT03_RS05505	COG0494	nUDIX hydrolase
HPT03_RS05515	COG3140	Belongs to the UPF0181 family
HPT03_RS05530	COG1115	amino acid carrier protein
HPT03_RS05535	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPT03_RS05540	COG1114	Component of the transport system for branched-chain amino acids
HPT03_RS05545	COG0561	phosphatase activity
HPT03_RS05560	COG1113	amino acid transport
HPT03_RS05580	COG1830	Aldolase
HPT03_RS05585	COG1597	lipid kinase activity
HPT03_RS05595	COG0745	RESPONSE REGULATOR receiver
HPT03_RS05600	COG2205	protein histidine kinase activity
HPT03_RS05605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPT03_RS05610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPT03_RS05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPT03_RS05620	COG3104	oligopeptide transport
HPT03_RS05640	COG2239	Acts as a magnesium transporter
HPT03_RS05650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPT03_RS05655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPT03_RS05660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPT03_RS05665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPT03_RS05670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPT03_RS05675	COG2233	PERMEase
HPT03_RS05680	COG0668	transmembrane transport
HPT03_RS05685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPT03_RS05690	COG2211	Major facilitator Superfamily
HPT03_RS05695	COG1393	Belongs to the ArsC family
HPT03_RS05700	COG4783	chaperone-mediated protein folding
HPT03_RS05705	COG0628	permease
HPT03_RS05710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPT03_RS05715	COG2716	regulation of RNA biosynthetic process
HPT03_RS05720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPT03_RS05725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPT03_RS05730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPT03_RS05735	COG2321	neutral zinc metallopeptidase
HPT03_RS05740	COG2707	UPF0756 membrane protein
HPT03_RS05745	COG1444	tRNA N-acetyltransferase activity
HPT03_RS05755	COG2832	Protein of unknown function (DUF454)
HPT03_RS05760	COG1876	peptidase activity
HPT03_RS05765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPT03_RS05770	COG1393	Belongs to the ArsC family
HPT03_RS05780	COG2197	response regulator
HPT03_RS05785	COG0281	malic enzyme
HPT03_RS05785	COG0280	phosphate acetyltransferase
HPT03_RS05800	COG1770	oligopeptidase
HPT03_RS05805	COG1629	transport
HPT03_RS05805	COG4206	TonB-dependent receptor
HPT03_RS05810	COG1570	exodeoxyribonuclease VII activity
HPT03_RS05815	COG0517	IMP dehydrogenase activity
HPT03_RS05815	COG0516	GMP reductase activity
HPT03_RS05820	COG0519	Catalyzes the synthesis of GMP from XMP
HPT03_RS05820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPT03_RS05825	COG3541	Predicted nucleotidyltransferase
HPT03_RS05840	COG1324	tolerance protein
HPT03_RS05845	COG2390	Transcriptional regulator
HPT03_RS05850	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPT03_RS05855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPT03_RS05860	COG3842	ATPase activity
HPT03_RS05905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPT03_RS05920	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HPT03_RS05925	COG1494	fructose-1,6-bisphosphatase
HPT03_RS05935	COG2197	response regulator
HPT03_RS05940	COG0322	excinuclease ABC activity
HPT03_RS05945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPT03_RS05975	COG3683	transport system, periplasmic component
HPT03_RS05980	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPT03_RS06000	COG2076	Multidrug Resistance protein
HPT03_RS06010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPT03_RS06015	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPT03_RS06020	COG2186	Transcriptional regulator
HPT03_RS06040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPT03_RS06045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPT03_RS06050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPT03_RS06055	COG3713	MltA-interacting MipA family protein
HPT03_RS06070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPT03_RS06075	COG3139	Protein of unknown function (DUF1315)
HPT03_RS06090	COG1335	isochorismatase
HPT03_RS06095	COG0252	asparaginase activity
HPT03_RS06100	COG0616	signal peptide processing
HPT03_RS06105	COG0778	Nitroreductase
HPT03_RS06110	COG0709	Synthesizes selenophosphate from selenide and ATP
HPT03_RS06115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPT03_RS06120	COG0708	Exodeoxyribonuclease III
HPT03_RS06125	COG0583	DNA-binding transcription factor activity
HPT03_RS06135	COG0788	formyltetrahydrofolate deformylase activity
HPT03_RS06140	COG3012	SEC-C Motif Domain Protein
HPT03_RS06145	COG0745	RESPONSE REGULATOR receiver
HPT03_RS06150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPT03_RS06165	COG1435	thymidine kinase activity
HPT03_RS06170	COG1012	belongs to the aldehyde dehydrogenase family
HPT03_RS06170	COG1454	alcohol dehydrogenase
HPT03_RS06175	COG2095	MarC family integral membrane protein
HPT03_RS06180	COG4608	Belongs to the ABC transporter superfamily
HPT03_RS06195	COG0601	transmembrane transport
HPT03_RS06200	COG4166	transmembrane transport
HPT03_RS06205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPT03_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPT03_RS06240	COG0444	Belongs to the ABC transporter superfamily
HPT03_RS06250	COG1396	sequence-specific DNA binding
HPT03_RS06260	COG3539	Fimbrial protein
HPT03_RS06270	COG3188	usher protein
HPT03_RS06285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPT03_RS06290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPT03_RS06295	COG1309	transcriptional regulator
HPT03_RS06300	COG1012	belongs to the aldehyde dehydrogenase family
HPT03_RS06305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HPT03_RS06310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPT03_RS06315	COG0402	S-adenosylhomocysteine deaminase activity
HPT03_RS06325	COG0113	porphobilinogen synthase activity
HPT03_RS06345	COG0589	response to stress
HPT03_RS06355	COG0589	response to stress
HPT03_RS06380	COG2966	Psort location CytoplasmicMembrane, score
HPT03_RS06385	COG3610	response to peptide
HPT03_RS06395	COG2356	endonuclease I
HPT03_RS06405	COG1702	phosphate starvation-inducible protein PhoH
HPT03_RS06410	COG3152	Membrane
HPT03_RS06425	COG1294	oxidase, subunit
HPT03_RS06430	COG1271	oxidase subunit
HPT03_RS06435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPT03_RS06440	COG1280	lysine exporter protein (LysE YggA)
HPT03_RS06450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPT03_RS06455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPT03_RS06460	COG4558	Periplasmic binding protein
HPT03_RS06465	COG3720	iron ion transport
HPT03_RS06470	COG4771	TonB-dependent receptor
HPT03_RS06475	COG4771	TonB-dependent receptor
HPT03_RS06485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPT03_RS06490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPT03_RS06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPT03_RS06495	COG0574	Belongs to the PEP-utilizing enzyme family
HPT03_RS06500	COG0628	permease
HPT03_RS06505	COG0247	lactate metabolic process
HPT03_RS06505	COG0277	FAD linked oxidase domain protein
HPT03_RS06510	COG2050	protein possibly involved in aromatic compounds catabolism
HPT03_RS06520	COG0316	Belongs to the HesB IscA family
HPT03_RS06525	COG0719	Fe-S assembly protein
HPT03_RS06530	COG0396	ATPase activity
HPT03_RS06535	COG0719	Fe-S assembly protein
HPT03_RS06540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPT03_RS06545	COG2166	iron-sulfur cluster assembly
HPT03_RS06550	COG1388	LysM domain
HPT03_RS06550	COG1376	ErfK ybiS ycfS ynhG family protein
HPT03_RS06565	COG0076	glutamate decarboxylase activity
HPT03_RS06570	COG0531	amino acid
HPT03_RS06590	COG0534	Mate efflux family protein
HPT03_RS06595	COG0307	riboflavin synthase, alpha
HPT03_RS06600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPT03_RS06605	COG2814	Major facilitator Superfamily
HPT03_RS06610	COG0583	DNA-binding transcription factor activity
HPT03_RS06615	COG1609	Transcriptional regulator
HPT03_RS06630	COG0730	response to heat
HPT03_RS06645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPT03_RS06650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPT03_RS06655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPT03_RS06660	COG0346	lactoylglutathione lyase activity
HPT03_RS06665	COG3313	Fe-S protein
HPT03_RS06680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPT03_RS06685	COG0259	pyridoxamine-phosphate oxidase activity
HPT03_RS06690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPT03_RS06705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPT03_RS06715	COG4172	Belongs to the ABC transporter superfamily
HPT03_RS06720	COG4171	peptide transport system, permease
HPT03_RS06730	COG4166	transmembrane transport
HPT03_RS06735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPT03_RS06740	COG1842	Phage shock protein A
HPT03_RS06750	COG1983	PspC domain protein
HPT03_RS06760	COG3106	COG3106 Predicted ATPase
HPT03_RS06765	COG3768	UPF0283 membrane protein
HPT03_RS06780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPT03_RS06785	COG4166	transmembrane transport
HPT03_RS06800	COG0598	Magnesium transport protein CorA
HPT03_RS06820	COG0346	lactoylglutathione lyase activity
HPT03_RS06835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPT03_RS06855	COG2917	probably involved in intracellular septation
HPT03_RS06870	COG3047	cAMP biosynthetic process
HPT03_RS06880	COG0159	tryptophan synthase activity
HPT03_RS06885	COG0133	tryptophan synthase activity
HPT03_RS06895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPT03_RS06900	COG0512	Glutamine amidotransferase of anthranilate synthase
HPT03_RS06905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPT03_RS06915	COG0009	L-threonylcarbamoyladenylate synthase
HPT03_RS06920	COG1187	pseudouridine synthase activity
HPT03_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS06940	COG0616	signal peptide processing
HPT03_RS06950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPT03_RS06975	COG0583	DNA-binding transcription factor activity
HPT03_RS06985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPT03_RS06995	COG1464	Belongs to the NlpA lipoprotein family
HPT03_RS07000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPT03_RS07005	COG0671	phosphoesterase, PA-phosphatase related
HPT03_RS07010	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPT03_RS07015	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPT03_RS07020	COG0284	orotidine-5'-phosphate decarboxylase activity
HPT03_RS07025	COG0023	Translation Initiation Factor
HPT03_RS07030	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HPT03_RS07035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPT03_RS07045	COG4659	FMN binding
HPT03_RS07055	COG4656	Part of a membrane complex involved in electron transport
HPT03_RS07065	COG4657	Part of a membrane complex involved in electron transport
HPT03_RS07075	COG0673	inositol 2-dehydrogenase activity
HPT03_RS07080	COG0385	Bile acid
HPT03_RS07085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPT03_RS07095	COG5339	Protein conserved in bacteria
HPT03_RS07100	COG0114	fumarate hydratase activity
HPT03_RS07110	COG2814	Major facilitator Superfamily
HPT03_RS07115	COG0583	DNA-binding transcription factor activity
HPT03_RS07120	COG1940	carbohydrate kinase activity
HPT03_RS07125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPT03_RS07140	COG4221	oxidoreductase activity
HPT03_RS07170	COG3157	Type VI secretion system effector, Hcp
HPT03_RS07195	COG4628	conserved protein (DUF2132)
HPT03_RS07200	COG1609	Transcriptional regulator
HPT03_RS07200	COG2207	Transcriptional regulator
HPT03_RS07205	COG0436	Aminotransferase
HPT03_RS07210	COG1757	Na H antiporter
HPT03_RS07215	COG2115	Belongs to the xylose isomerase family
HPT03_RS07220	COG1070	Carbohydrate kinase
HPT03_RS07240	COG0443	Heat shock 70 kDa protein
HPT03_RS07250	COG1538	Outer membrane efflux protein
HPT03_RS07255	COG1289	transmembrane transporter activity
HPT03_RS07270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HPT03_RS07275	COG0477	Major facilitator Superfamily
HPT03_RS07285	COG2814	Major facilitator Superfamily
HPT03_RS07295	COG0402	S-adenosylhomocysteine deaminase activity
HPT03_RS07300	COG1671	Belongs to the UPF0178 family
HPT03_RS07305	COG0488	(ABC) transporter
HPT03_RS07315	COG1309	transcriptional regulator
HPT03_RS07325	COG0583	DNA-binding transcription factor activity
HPT03_RS07335	COG2814	Major facilitator Superfamily
HPT03_RS07355	COG1464	Belongs to the NlpA lipoprotein family
HPT03_RS07375	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPT03_RS07390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPT03_RS07390	COG2169	Transcriptional regulator
HPT03_RS07395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPT03_RS07415	COG0251	oxidation-reduction process
HPT03_RS07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPT03_RS07435	COG2376	Dihydroxyacetone kinase
HPT03_RS07455	COG1349	DNA-binding transcription factor activity
HPT03_RS07460	COG0243	molybdopterin cofactor binding
HPT03_RS07465	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS07470	COG3302	dmso reductase anchor subunit
HPT03_RS07475	COG3381	protein complex oligomerization
HPT03_RS07480	COG0590	tRNA wobble adenosine to inosine editing
HPT03_RS07485	COG0666	response to abiotic stimulus
HPT03_RS07490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HPT03_RS07495	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPT03_RS07500	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPT03_RS07505	COG2205	protein histidine kinase activity
HPT03_RS07510	COG0745	RESPONSE REGULATOR receiver
HPT03_RS07515	COG0842	Transport permease protein
HPT03_RS07520	COG0842	Transport permease protein
HPT03_RS07520	COG1129	ABC transporter
HPT03_RS07525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPT03_RS07535	COG4974	Belongs to the 'phage' integrase family
HPT03_RS07540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPT03_RS07580	COG3634	alkyl hydroperoxide reductase activity
HPT03_RS07600	COG1695	Transcriptional regulator
HPT03_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS07610	COG3321	synthase
HPT03_RS07610	COG0604	alcohol dehydrogenase
HPT03_RS07625	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS07630	COG0243	molybdopterin cofactor binding
HPT03_RS07635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPT03_RS07640	COG0589	response to stress
HPT03_RS07645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPT03_RS07650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPT03_RS07660	COG0531	amino acid
HPT03_RS07675	COG3188	usher protein
HPT03_RS07725	COG3784	Protein of unknown function (DUF1318)
HPT03_RS07735	COG2911	Protein conserved in bacteria
HPT03_RS07740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPT03_RS07755	COG2207	Transcriptional regulator
HPT03_RS07755	COG3708	Transcriptional regulator
HPT03_RS07765	COG4619	ABC transporter
HPT03_RS07770	COG0390	transport system, permease component
HPT03_RS07775	COG2983	Belongs to the UPF0260 family
HPT03_RS07780	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPT03_RS07785	COG2951	lytic endotransglycosylase activity
HPT03_RS07790	COG3100	YcgL domain-containing protein
HPT03_RS07795	COG0850	regulation of cytokinetic process
HPT03_RS07800	COG2894	cell division
HPT03_RS07805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPT03_RS07810	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPT03_RS07815	COG0318	PFAM AMP-dependent synthetase and ligase
HPT03_RS07820	COG3065	identical protein binding
HPT03_RS07830	COG1199	ATP-dependent helicase activity
HPT03_RS07835	COG0251	oxidation-reduction process
HPT03_RS07840	COG0702	epimerase
HPT03_RS07845	COG2076	Multidrug Resistance protein
HPT03_RS07850	COG2076	Multidrug Resistance protein
HPT03_RS07855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPT03_RS07860	COG1737	Transcriptional regulator
HPT03_RS07865	COG0469	pyruvate kinase activity
HPT03_RS07870	COG1560	Kdo2-lipid A biosynthetic process
HPT03_RS07875	COG0739	heme binding
HPT03_RS07880	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPT03_RS07885	COG1121	(ABC) transporter
HPT03_RS07890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPT03_RS07995	COG2801	Transposase and inactivated derivatives
HPT03_RS08005	COG4290	ribonuclease
HPT03_RS08025	COG3209	COG3209 Rhs family protein
HPT03_RS08035	COG3501	Rhs element vgr protein
HPT03_RS08045	COG2255	four-way junction helicase activity
HPT03_RS08050	COG0632	four-way junction helicase activity
HPT03_RS08055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPT03_RS08060	COG0217	transcriptional regulatory protein
HPT03_RS08065	COG0494	nUDIX hydrolase
HPT03_RS08070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPT03_RS08075	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HPT03_RS08080	COG2226	methyltransferase
HPT03_RS08085	COG0500	methyltransferase
HPT03_RS08090	COG0488	(ABC) transporter
HPT03_RS08100	COG3142	Participates in the control of copper homeostasis
HPT03_RS08105	COG3102	Protein conserved in bacteria
HPT03_RS08110	COG0018	arginyl-trna synthetase
HPT03_RS08120	COG0728	peptidoglycan biosynthetic process
HPT03_RS08125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPT03_RS08130	COG0477	Major facilitator Superfamily
HPT03_RS08140	COG3381	protein complex oligomerization
HPT03_RS08155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPT03_RS08165	COG0659	secondary active sulfate transmembrane transporter activity
HPT03_RS08175	COG1242	4 iron, 4 sulfur cluster binding
HPT03_RS08180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPT03_RS08185	COG2912	Transglutaminase-like superfamily
HPT03_RS08195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPT03_RS08200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPT03_RS08205	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPT03_RS08210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPT03_RS08215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPT03_RS08225	COG0193	aminoacyl-tRNA hydrolase activity
HPT03_RS08230	COG0012	GTP binding
HPT03_RS08265	COG3209	COG3209 Rhs family protein
HPT03_RS08330	COG0586	Pfam SNARE associated Golgi protein
HPT03_RS08345	COG2186	Transcriptional regulator
HPT03_RS08350	COG0579	oxidoreductase
HPT03_RS08355	COG2207	Transcriptional regulator
HPT03_RS08360	COG0095	Lipoate-protein ligase
HPT03_RS08365	COG0791	NLP P60 protein
HPT03_RS08370	COG2076	Multidrug Resistance protein
HPT03_RS08375	COG2076	Multidrug Resistance protein
HPT03_RS08380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPT03_RS08385	COG0726	polysaccharide deacetylase
HPT03_RS08390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPT03_RS08390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPT03_RS08395	COG0463	Glycosyl transferase, family 2
HPT03_RS08400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPT03_RS08405	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPT03_RS08410	COG4139	cobalamin transport
HPT03_RS08415	COG0776	regulation of translation
HPT03_RS08420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPT03_RS08420	COG0072	phenylalanine-tRNA ligase activity
HPT03_RS08425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPT03_RS08435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPT03_RS08440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPT03_RS08445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPT03_RS08450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPT03_RS08455	COG3539	Fimbrial protein
HPT03_RS08465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPT03_RS08485	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPT03_RS08490	COG1121	(ABC) transporter
HPT03_RS08495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPT03_RS08500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPT03_RS08505	COG3001	Fructosamine kinase
HPT03_RS08515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPT03_RS08530	COG1988	membrane-bound metal-dependent
HPT03_RS08540	COG0501	Belongs to the peptidase M48B family
HPT03_RS08555	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPT03_RS08560	COG1956	GAF domain-containing protein
HPT03_RS08565	COG2995	paraquat-inducible protein a
HPT03_RS08570	COG3008	intermembrane lipid transfer
HPT03_RS08585	COG1276	copper resistance
HPT03_RS08590	COG2372	response to copper ion
HPT03_RS08595	COG1528	Iron-storage protein
HPT03_RS08615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPT03_RS08620	COG1598	PFAM Uncharacterised protein family UPF0150
HPT03_RS08625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPT03_RS08635	COG0024	Methionine aminopeptidase
HPT03_RS08665	COG2841	Protein conserved in bacteria
HPT03_RS08675	COG3272	Protein of unknown function (DUF1722)
HPT03_RS08690	COG0500	methyltransferase
HPT03_RS08695	COG3969	phosphoadenosine phosphosulfate
HPT03_RS08700	COG1475	DNA binding
HPT03_RS08710	COG0572	uridine kinase
HPT03_RS08720	COG0702	epimerase
HPT03_RS08725	COG1733	regulation of RNA biosynthetic process
HPT03_RS08735	COG0071	Belongs to the small heat shock protein (HSP20) family
HPT03_RS08740	COG1278	Cold shock
HPT03_RS08770	COG0538	isocitrate dehydrogenase activity
HPT03_RS08875	COG1802	Transcriptional regulator
HPT03_RS08875	COG4626	Terminase
HPT03_RS08920	COG3772	lysozyme
HPT03_RS08935	COG4581	dead DEAH box helicase
HPT03_RS08945	COG0071	Belongs to the small heat shock protein (HSP20) family
HPT03_RS08950	COG1278	Cold shock
HPT03_RS08960	COG1403	HNH endonuclease
HPT03_RS08970	COG1846	Transcriptional regulator
HPT03_RS09005	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPT03_RS09015	COG0582	viral genome integration into host DNA
HPT03_RS09020	COG0538	isocitrate dehydrogenase activity
HPT03_RS09025	COG1187	pseudouridine synthase activity
HPT03_RS09035	COG0482	sulfurtransferase activity
HPT03_RS09040	COG2915	High frequency lysogenization protein hflD homolog
HPT03_RS09045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPT03_RS09050	COG0745	RESPONSE REGULATOR receiver
HPT03_RS09055	COG2205	protein histidine kinase activity
HPT03_RS09060	COG2850	peptidyl-arginine hydroxylation
HPT03_RS09075	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPT03_RS09085	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPT03_RS09090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPT03_RS09095	COG3134	Outer membrane lipoprotein
HPT03_RS09100	COG1252	NADH dehydrogenase
HPT03_RS09110	COG1472	Belongs to the glycosyl hydrolase 3 family
HPT03_RS09120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HPT03_RS09125	COG5633	Lipoprotein
HPT03_RS09130	COG0537	adenosine 5'-monophosphoramidase activity
HPT03_RS09135	COG0084	hydrolase, TatD family'
HPT03_RS09140	COG0470	DNA polymerase III
HPT03_RS09145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPT03_RS09150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPT03_RS09155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPT03_RS09160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPT03_RS09165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPT03_RS09180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPT03_RS09185	COG0416	fatty acid biosynthetic process
HPT03_RS09190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPT03_RS09195	COG1399	metal-binding, possibly nucleic acid-binding protein
HPT03_RS09200	COG0424	maF-like protein
HPT03_RS09210	COG0564	pseudouridine synthase activity
HPT03_RS09215	COG1530	ribonuclease E activity
HPT03_RS09220	COG2926	Belongs to the UPF0265 family
HPT03_RS09225	COG2211	Major facilitator Superfamily
HPT03_RS09230	COG2925	Exonuclease
HPT03_RS09235	COG0277	FAD linked oxidase domain protein
HPT03_RS09240	COG0583	DNA-binding transcription factor activity
HPT03_RS09245	COG3961	Belongs to the TPP enzyme family
HPT03_RS09255	COG0531	amino acid
HPT03_RS09260	COG4771	TonB-dependent receptor
HPT03_RS09265	COG0833	amino acid
HPT03_RS09270	COG0583	DNA-binding transcription factor activity
HPT03_RS09275	COG2855	membrane
HPT03_RS09290	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPT03_RS09295	COG0494	nUDIX hydrolase
HPT03_RS09305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPT03_RS09320	COG0671	phosphoesterase, PA-phosphatase related
HPT03_RS09325	COG0791	NLP P60 protein
HPT03_RS09335	COG2814	Major facilitator Superfamily
HPT03_RS09340	COG1187	pseudouridine synthase activity
HPT03_RS09345	COG1061	Type III restriction enzyme res subunit
HPT03_RS09350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPT03_RS09355	COG3081	Nucleoid-associated protein
HPT03_RS09360	COG3082	Protein of unknown function (DUF1414)
HPT03_RS09365	COG3083	sulfuric ester hydrolase activity
HPT03_RS09475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPT03_RS09475	COG2755	lipolytic protein G-D-S-L family
HPT03_RS09485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPT03_RS09510	COG1560	Kdo2-lipid A biosynthetic process
HPT03_RS09515	COG1278	Cold shock
HPT03_RS09530	COG3708	Transcriptional regulator
HPT03_RS09530	COG2207	Transcriptional regulator
HPT03_RS09540	COG0656	L-ascorbic acid biosynthetic process
HPT03_RS09545	COG0583	DNA-binding transcription factor activity
HPT03_RS09560	COG3615	Tellurite resistance protein tehB
HPT03_RS09570	COG0456	acetyltransferase
HPT03_RS09580	COG2920	part of a sulfur-relay system
HPT03_RS09585	COG1254	Belongs to the acylphosphatase family
HPT03_RS09590	COG3785	DNA binding
HPT03_RS09595	COG1832	CoA-binding protein
HPT03_RS09600	COG1803	Methylglyoxal synthase
HPT03_RS09605	COG0210	DNA helicase
HPT03_RS09610	COG1289	transmembrane transporter activity
HPT03_RS09615	COG3070	regulator of competence-specific genes
HPT03_RS09625	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPT03_RS09625	COG2885	chlorophyll binding
HPT03_RS09630	COG3120	sequence-specific DNA binding
HPT03_RS09635	COG1067	ATP-dependent peptidase activity
HPT03_RS09640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPT03_RS09645	COG3130	regulation of translation
HPT03_RS09655	COG3009	Protein conserved in bacteria
HPT03_RS09660	COG3008	intermembrane lipid transfer
HPT03_RS09660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPT03_RS09665	COG2995	paraquat-inducible protein a
HPT03_RS09670	COG0488	(ABC) transporter
HPT03_RS09675	COG0116	Belongs to the methyltransferase superfamily
HPT03_RS09675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPT03_RS09680	COG0633	Ferredoxin
HPT03_RS09680	COG3217	Mosc domain protein beta barrel domain protein
HPT03_RS09690	COG0167	dihydroorotate dehydrogenase activity
HPT03_RS09700	COG0308	aminopeptidase N
HPT03_RS09705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPT03_RS09715	COG0017	Asparaginyl-tRNA synthetase
HPT03_RS09720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPT03_RS09725	COG1448	Aminotransferase
HPT03_RS09850	COG3501	Rhs element vgr protein
HPT03_RS09940	COG3157	Type VI secretion system effector, Hcp
HPT03_RS09945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPT03_RS09950	COG3108	Peptidase M15
HPT03_RS09955	COG2989	Protein conserved in bacteria
HPT03_RS09960	COG3700	Belongs to the class B bacterial acid phosphatase family
HPT03_RS09970	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HPT03_RS09975	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPT03_RS09980	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPT03_RS09985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPT03_RS09990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPT03_RS09995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPT03_RS10000	COG2835	tetraacyldisaccharide 4'-kinase activity
HPT03_RS10010	COG1663	tetraacyldisaccharide 4'-kinase activity
HPT03_RS10015	COG1132	(ABC) transporter
HPT03_RS10020	COG2333	competence protein COMEC
HPT03_RS10020	COG0658	competence protein
HPT03_RS10025	COG0776	regulation of translation
HPT03_RS10030	COG0539	negative regulation of cytoplasmic translation
HPT03_RS10035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPT03_RS10040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPT03_RS10045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPT03_RS10060	COG0252	asparaginase activity
HPT03_RS10065	COG1944	ATP diphosphatase activity
HPT03_RS10070	COG2116	formate transmembrane transporter activity
HPT03_RS10075	COG1882	Formate acetyltransferase
HPT03_RS10080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPT03_RS10090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPT03_RS10100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPT03_RS10105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPT03_RS10110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPT03_RS10115	COG3107	peptidoglycan biosynthetic process
HPT03_RS10115	COG1674	ftsk spoiiie
HPT03_RS10125	COG0492	ferredoxin-NADP+ reductase activity
HPT03_RS10135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPT03_RS10140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPT03_RS10145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPT03_RS10150	COG0542	response to heat
HPT03_RS10155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPT03_RS10160	COG1278	Cold shock
HPT03_RS10165	COG1136	(ABC) transporter
HPT03_RS10165	COG0577	efflux transmembrane transporter activity
HPT03_RS10170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPT03_RS10175	COG3593	DNA synthesis involved in DNA repair
HPT03_RS10180	COG2431	L-lysine efflux transmembrane transporter activity
HPT03_RS10185	COG0702	epimerase
HPT03_RS10190	COG1126	abc transporter atp-binding protein
HPT03_RS10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPT03_RS10200	COG4215	(ABC) transporter
HPT03_RS10205	COG4160	amino acid transport
HPT03_RS10210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPT03_RS10225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPT03_RS10230	COG0675	Transposase, IS605 OrfB family
HPT03_RS10240	COG0671	phosphoesterase, PA-phosphatase related
HPT03_RS10245	COG0814	amino acid
HPT03_RS10250	COG1760	l-serine dehydratase
HPT03_RS10255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPT03_RS10260	COG1686	Belongs to the peptidase S11 family
HPT03_RS10265	COG0625	glutathione transferase activity
HPT03_RS10270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPT03_RS10275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPT03_RS10280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPT03_RS10290	COG0131	Imidazoleglycerol-phosphate dehydratase
HPT03_RS10290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPT03_RS10295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPT03_RS10300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPT03_RS10305	COG0107	imidazoleglycerol-phosphate synthase activity
HPT03_RS10310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPT03_RS10310	COG0140	phosphoribosyl-ATP diphosphatase activity
HPT03_RS10315	COG1454	alcohol dehydrogenase
HPT03_RS10320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPT03_RS10325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPT03_RS10340	COG1253	flavin adenine dinucleotide binding
HPT03_RS10345	COG3069	C4-dicarboxylate transmembrane transporter activity
HPT03_RS10350	COG2982	Protein involved in outer membrane biogenesis
HPT03_RS10355	COG0717	Belongs to the dCTP deaminase family
HPT03_RS10360	COG0572	uridine kinase
HPT03_RS10365	COG0489	protein tyrosine kinase activity
HPT03_RS10370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPT03_RS10370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPT03_RS10375	COG1380	Effector of murein hydrolase LrgA
HPT03_RS10380	COG1346	cytolysis
HPT03_RS10385	COG0295	cytidine deaminase activity
HPT03_RS10390	COG0281	malic enzyme
HPT03_RS10395	COG2949	membrane
HPT03_RS10400	COG2311	Membrane
HPT03_RS10405	COG0302	gtp cyclohydrolase
HPT03_RS10410	COG0477	Major facilitator Superfamily
HPT03_RS10420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPT03_RS10460	COG2897	thiosulfate sulfurtransferase activity
HPT03_RS10470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPT03_RS10475	COG0513	Belongs to the DEAD box helicase family
HPT03_RS10480	COG1309	transcriptional regulator
HPT03_RS10490	COG1131	(ABC) transporter
HPT03_RS10495	COG0842	Transport permease protein
HPT03_RS10500	COG0842	Transport permease protein
HPT03_RS10505	COG0670	Belongs to the BI1 family
HPT03_RS10510	COG0314	molybdopterin synthase activity
HPT03_RS10515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPT03_RS10520	COG0315	cyclic pyranopterin monophosphate synthase activity
HPT03_RS10525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPT03_RS10530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPT03_RS10540	COG0556	nucleotide-excision repair
HPT03_RS10550	COG2226	methyltransferase
HPT03_RS10555	COG0156	8-amino-7-oxononanoate synthase activity
HPT03_RS10560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPT03_RS10570	COG2706	6-phosphogluconolactonase activity
HPT03_RS10575	COG0561	phosphatase activity
HPT03_RS10580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPT03_RS10585	COG4149	molybdate abc transporter
HPT03_RS10590	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPT03_RS10600	COG2005	Transcriptional regulator
HPT03_RS10600	COG3585	molybdate ion transport
HPT03_RS10615	COG2831	hemolysin activation secretion protein
HPT03_RS10620	COG1119	ATPase activity
HPT03_RS10625	COG0588	phosphoglycerate mutase activity
HPT03_RS10630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPT03_RS10655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HPT03_RS10660	COG2885	chlorophyll binding
HPT03_RS10665	COG0823	Involved in the tonB-independent uptake of proteins
HPT03_RS10670	COG3064	Membrane
HPT03_RS10675	COG0848	biopolymer transport protein
HPT03_RS10680	COG0811	peptide transport
HPT03_RS10685	COG0824	Thioesterase
HPT03_RS10695	COG0477	Major facilitator Superfamily
HPT03_RS10700	COG0583	DNA-binding transcription factor activity
HPT03_RS10705	COG3790	cyd operon protein YbgE
HPT03_RS10710	COG4890	Cyd operon protein YbgT
HPT03_RS10715	COG1294	oxidase, subunit
HPT03_RS10720	COG1271	oxidase subunit
HPT03_RS10725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPT03_RS10730	COG0045	succinate-CoA ligase (ADP-forming) activity
HPT03_RS10735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPT03_RS10740	COG0567	Dehydrogenase, E1 component
HPT03_RS10750	COG1053	succinate dehydrogenase
HPT03_RS10755	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPT03_RS10775	COG2814	Major facilitator Superfamily
HPT03_RS10785	COG0714	Associated with various cellular activities
HPT03_RS10790	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPT03_RS10795	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HPT03_RS10805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPT03_RS10820	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPT03_RS10825	COG4807	Protein conserved in bacteria
HPT03_RS10830	COG0033	Phosphoglucomutase
HPT03_RS10835	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPT03_RS10840	COG0596	Alpha beta hydrolase
HPT03_RS10850	COG0716	FMN binding
HPT03_RS10855	COG0735	belongs to the Fur family
HPT03_RS10870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPT03_RS10975	COG1674	ftsk spoiiie
HPT03_RS10975	COG1178	ABC-type Fe3 transport system permease component
HPT03_RS11090	COG3772	lysozyme
HPT03_RS11105	COG3477	response to acidic pH
HPT03_RS11135	COG0305	Participates in initiation and elongation during chromosome replication
HPT03_RS11265	COG0582	viral genome integration into host DNA
HPT03_RS11275	COG0363	glucosamine-6-phosphate deaminase activity
HPT03_RS11280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPT03_RS11285	COG1846	Transcriptional regulator
HPT03_RS11285	COG1940	carbohydrate kinase activity
HPT03_RS11335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HPT03_RS11340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPT03_RS11345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPT03_RS11350	COG1702	phosphate starvation-inducible protein PhoH
HPT03_RS11355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPT03_RS11365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPT03_RS11375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPT03_RS11400	COG0765	amino acid transport
HPT03_RS11405	COG0765	amino acid transport
HPT03_RS11410	COG1126	abc transporter atp-binding protein
HPT03_RS11415	COG0495	leucyl-tRNA aminoacylation
HPT03_RS11420	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPT03_RS11425	COG1466	dna polymerase III delta subunit
HPT03_RS11430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPT03_RS11440	COG0799	negative regulation of ribosome biogenesis
HPT03_RS11445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPT03_RS11450	COG0768	penicillin binding
HPT03_RS11455	COG0772	Belongs to the SEDS family
HPT03_RS11460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPT03_RS11465	COG1686	Belongs to the peptidase S11 family
HPT03_RS11475	COG0321	lipoyl(octanoyl) transferase activity
HPT03_RS11480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPT03_RS11485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPT03_RS11500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPT03_RS11510	COG1780	Probably involved in ribonucleotide reductase function
HPT03_RS11525	COG4175	Glycine betaine
HPT03_RS11530	COG4176	ABC-type proline glycine betaine transport system permease component
HPT03_RS11535	COG2113	Glycine betaine
HPT03_RS11540	COG1629	transport
HPT03_RS11545	COG2814	Major facilitator Superfamily
HPT03_RS11550	COG1846	Transcriptional regulator
HPT03_RS11555	COG1335	isochorismatase
HPT03_RS11560	COG2814	Major facilitator Superfamily
HPT03_RS11570	COG1566	PFAM secretion protein HlyD family protein
HPT03_RS11575	COG2814	Major facilitator Superfamily
HPT03_RS11580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPT03_RS11595	COG1042	CoA-binding domain protein
HPT03_RS11595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPT03_RS11595	COG0045	succinate-CoA ligase (ADP-forming) activity
HPT03_RS11600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPT03_RS11605	COG5544	Lipoprotein
HPT03_RS11635	COG0542	response to heat
HPT03_RS11645	COG0564	pseudouridine synthase activity
HPT03_RS11650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPT03_RS11655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPT03_RS11660	COG1605	Chorismate mutase
HPT03_RS11660	COG0077	Prephenate dehydratase
HPT03_RS11665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPT03_RS11680	COG1605	Chorismate mutase
HPT03_RS11680	COG0287	Prephenate dehydrogenase
HPT03_RS11685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPT03_RS11690	COG0335	large ribosomal subunit rRNA binding
HPT03_RS11695	COG0336	Belongs to the RNA methyltransferase TrmD family
HPT03_RS11705	COG0228	four-way junction DNA binding
HPT03_RS11710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPT03_RS11715	COG4137	Cytochrome C assembly protein
HPT03_RS11720	COG4536	flavin adenine dinucleotide binding
HPT03_RS11725	COG1854	S-ribosylhomocysteine lyase activity
HPT03_RS11730	COG2918	glutathione biosynthetic process
HPT03_RS11760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPT03_RS11765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPT03_RS11770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPT03_RS11775	COG1546	Belongs to the CinA family
HPT03_RS11780	COG2814	Major facilitator Superfamily
HPT03_RS11785	COG0318	PFAM AMP-dependent synthetase and ligase
HPT03_RS11785	COG0204	Acyl-transferase
HPT03_RS11790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPT03_RS11795	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPT03_RS11800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPT03_RS11815	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPT03_RS11820	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPT03_RS11825	COG4774	siderophore transport
HPT03_RS11830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPT03_RS11840	COG3237	CsbD-like
HPT03_RS11845	COG2991	Protein conserved in bacteria
HPT03_RS11850	COG1477	protein flavinylation
HPT03_RS11855	COG2871	sodium ion transport
HPT03_RS11860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPT03_RS11865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPT03_RS11870	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPT03_RS11875	COG1805	sodium ion transport
HPT03_RS11880	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPT03_RS11885	COG3034	peptidoglycan biosynthetic process
HPT03_RS11890	COG0121	glutamine amidotransferase
HPT03_RS11895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPT03_RS11900	COG1960	acyl-CoA dehydrogenase activity
HPT03_RS11910	COG0583	DNA-binding transcription factor activity
HPT03_RS11915	COG0583	DNA-binding transcription factor activity
HPT03_RS11935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPT03_RS11940	COG0189	ligase activity
HPT03_RS11945	COG1678	Uncharacterized ACR, COG1678
HPT03_RS11950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPT03_RS11955	COG2805	Type II/IV secretion system protein
HPT03_RS11960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPT03_RS11965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPT03_RS11970	COG0762	integral membrane protein
HPT03_RS11975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPT03_RS11980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPT03_RS11985	COG4607	ABC-type enterochelin transport system periplasmic component
HPT03_RS11995	COG2066	Belongs to the glutaminase family
HPT03_RS12000	COG3171	Protein conserved in bacteria
HPT03_RS12010	COG1194	a g-specific adenine glycosylase
HPT03_RS12015	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPT03_RS12020	COG0741	lytic transglycosylase activity
HPT03_RS12055	COG2368	4-hydroxyphenylacetate
HPT03_RS12125	COG1982	Orn Lys Arg decarboxylase major
HPT03_RS12130	COG0531	amino acid
HPT03_RS12135	COG1309	transcriptional regulator
HPT03_RS12145	COG1263	PTS System
HPT03_RS12145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS12150	COG1554	hydrolase, family 65, central catalytic
HPT03_RS12155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPT03_RS12210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPT03_RS12215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPT03_RS12225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPT03_RS12240	COG3539	Fimbrial protein
HPT03_RS12260	COG3188	usher protein
HPT03_RS12270	COG3539	Fimbrial protein
HPT03_RS12275	COG0582	viral genome integration into host DNA
HPT03_RS12295	COG3539	Fimbrial protein
HPT03_RS12300	COG3539	Fimbrial protein
HPT03_RS12305	COG3121	Chaperone
HPT03_RS12310	COG3188	usher protein
HPT03_RS12315	COG3539	Fimbrial protein
HPT03_RS12320	COG1234	tRNA 3'-trailer cleavage
HPT03_RS12335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPT03_RS12340	COG1846	Transcriptional regulator
HPT03_RS12355	COG3104	oligopeptide transport
HPT03_RS12360	COG2314	TM2 domain
HPT03_RS12370	COG0126	phosphoglycerate kinase activity
HPT03_RS12375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPT03_RS12380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPT03_RS12395	COG2814	Major facilitator Superfamily
HPT03_RS12400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPT03_RS12405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPT03_RS12410	COG0019	diaminopimelate decarboxylase activity
HPT03_RS12430	COG1120	ATPase activity
HPT03_RS12435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPT03_RS12445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPT03_RS12450	COG0328	RNA-DNA hybrid ribonuclease activity
HPT03_RS12455	COG2226	methyltransferase
HPT03_RS12460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPT03_RS12465	COG1388	LysM domain
HPT03_RS12465	COG0741	lytic transglycosylase activity
HPT03_RS12470	COG3961	Belongs to the TPP enzyme family
HPT03_RS12475	COG0471	metal ion transport
HPT03_RS12480	COG0148	phosphopyruvate hydratase activity
HPT03_RS12485	COG0504	CTP synthase activity
HPT03_RS12490	COG3956	TIGRFAM MazG family protein
HPT03_RS12495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPT03_RS12500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPT03_RS12510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPT03_RS12520	COG0316	Belongs to the HesB IscA family
HPT03_RS12525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPT03_RS12530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPT03_RS12535	COG1643	Atp-dependent helicase
HPT03_RS12540	COG1489	DNA binding
HPT03_RS12560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPT03_RS12565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPT03_RS12570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPT03_RS12575	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HPT03_RS12585	COG3851	Histidine kinase
HPT03_RS12590	COG2271	Major facilitator Superfamily
HPT03_RS12595	COG1840	ABC-type Fe3 transport system, periplasmic component
HPT03_RS12605	COG3842	ATPase activity
HPT03_RS12610	COG3048	D-serine ammonia-lyase activity
HPT03_RS12615	COG2610	gluconate transmembrane transporter activity
HPT03_RS12620	COG0583	DNA-binding transcription factor activity
HPT03_RS12625	COG0754	glutathionylspermidine amidase activity
HPT03_RS12640	COG4633	Protein conserved in bacteria
HPT03_RS12655	COG2837	iron assimilation
HPT03_RS12665	COG0243	molybdopterin cofactor binding
HPT03_RS12670	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS12685	COG0501	Belongs to the peptidase M48B family
HPT03_RS12695	COG0477	Major facilitator Superfamily
HPT03_RS12700	COG0842	Transport permease protein
HPT03_RS12705	COG1131	(ABC) transporter
HPT03_RS12710	COG0288	reversible hydration of carbon dioxide
HPT03_RS12720	COG2132	Multicopper oxidase
HPT03_RS12755	COG5441	Belongs to the UPF0261 family
HPT03_RS12760	COG5564	TIM-barrel signal transduction protein
HPT03_RS12765	COG0673	inositol 2-dehydrogenase activity
HPT03_RS12770	COG0534	Mate efflux family protein
HPT03_RS12780	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPT03_RS12785	COG3069	C4-dicarboxylate transmembrane transporter activity
HPT03_RS12795	COG0523	cobalamin synthesis protein
HPT03_RS12800	COG2879	small protein
HPT03_RS12805	COG1966	Carbon starvation protein
HPT03_RS12810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPT03_RS12815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPT03_RS12825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPT03_RS12840	COG1196	nuclear chromosome segregation
HPT03_RS12840	COG3264	Mechanosensitive ion channel
HPT03_RS12845	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPT03_RS12850	COG1309	transcriptional regulator
HPT03_RS12855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPT03_RS12860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPT03_RS12880	COG1946	Acyl-CoA thioesterase
HPT03_RS12885	COG0004	ammonium transporteR
HPT03_RS12890	COG0347	Belongs to the P(II) protein family
HPT03_RS12895	COG1132	(ABC) transporter
HPT03_RS12900	COG1132	(ABC) transporter
HPT03_RS12905	COG1522	sequence-specific DNA binding
HPT03_RS12910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPT03_RS12915	COG0824	Thioesterase
HPT03_RS12920	COG1555	photosystem II stabilization
HPT03_RS12920	COG1596	polysaccharide export
HPT03_RS12925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPT03_RS12930	COG0776	regulation of translation
HPT03_RS12935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPT03_RS12940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPT03_RS12945	COG0740	serine-type endopeptidase activity
HPT03_RS12950	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPT03_RS12955	COG0271	Belongs to the BolA IbaG family
HPT03_RS12960	COG3056	Lipoprotein
HPT03_RS12965	COG2223	nitrite transmembrane transporter activity
HPT03_RS12970	COG0513	Belongs to the DEAD box helicase family
HPT03_RS12980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPT03_RS12985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPT03_RS12990	COG1845	cytochrome c oxidase, subunit III
HPT03_RS12995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPT03_RS13000	COG0109	protoheme IX farnesyltransferase activity
HPT03_RS13005	COG2814	Major facilitator Superfamily
HPT03_RS13010	COG1666	GTP binding
HPT03_RS13015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPT03_RS13020	COG0693	protein deglycase activity
HPT03_RS13030	COG0301	tRNA thio-modification
HPT03_RS13030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPT03_RS13040	COG0142	geranyltranstransferase activity
HPT03_RS13045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPT03_RS13050	COG1869	D-ribose catabolic process
HPT03_RS13055	COG1129	ABC transporter
HPT03_RS13060	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPT03_RS13065	COG1879	ABC-type sugar transport system periplasmic component
HPT03_RS13070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPT03_RS13075	COG1609	Transcriptional regulator
HPT03_RS13080	COG0675	Transposase, IS605 OrfB family
HPT03_RS13090	COG2824	Alkylphosphonate utilization operon protein PhnA
HPT03_RS13100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPT03_RS13105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPT03_RS13110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPT03_RS13110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPT03_RS13115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPT03_RS13120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPT03_RS13125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPT03_RS13130	COG1862	Preprotein translocase
HPT03_RS13135	COG0343	queuine tRNA-ribosyltransferase activity
HPT03_RS13140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPT03_RS13145	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPT03_RS13150	COG0450	alkyl hydroperoxide reductase
HPT03_RS13160	COG3121	Chaperone
HPT03_RS13185	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS13190	COG2414	aldehyde ferredoxin oxidoreductase
HPT03_RS13200	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS13205	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPT03_RS13240	COG1114	Component of the transport system for branched-chain amino acids
HPT03_RS13245	COG5002	protein histidine kinase activity
HPT03_RS13255	COG0420	3'-5' exonuclease activity
HPT03_RS13260	COG0419	ATPase involved in DNA repair
HPT03_RS13280	COG0737	Belongs to the 5'-nucleotidase family
HPT03_RS13285	COG3719	Belongs to the RNase T2 family
HPT03_RS13290	COG0737	Belongs to the 5'-nucleotidase family
HPT03_RS13300	COG2974	May be involved in recombination
HPT03_RS13305	COG0425	Belongs to the sulfur carrier protein TusA family
HPT03_RS13310	COG2391	methyltransferase activity
HPT03_RS13315	COG0309	Hydrogenase expression formation protein (HypE)
HPT03_RS13320	COG0409	Hydrogenase expression formation protein
HPT03_RS13325	COG0298	carbon dioxide binding
HPT03_RS13330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPT03_RS13335	COG1773	rubredoxin
HPT03_RS13340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPT03_RS13345	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPT03_RS13350	COG5557	Pfam Polysulphide reductase, NrfD
HPT03_RS13355	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS13360	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPT03_RS13370	COG0848	biopolymer transport protein
HPT03_RS13375	COG0811	peptide transport
HPT03_RS13380	COG0626	cystathionine gamma-synthase activity
HPT03_RS13390	COG1979	alcohol dehydrogenase
HPT03_RS13420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPT03_RS13425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPT03_RS13430	COG1047	Peptidyl-prolyl cis-trans
HPT03_RS13435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPT03_RS13440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPT03_RS13445	COG0196	riboflavin kinase activity
HPT03_RS13455	COG0268	Binds directly to 16S ribosomal RNA
HPT03_RS13460	COG0583	DNA-binding transcription factor activity
HPT03_RS13465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPT03_RS13470	COG0484	heat shock protein binding
HPT03_RS13475	COG0443	Heat shock 70 kDa protein
HPT03_RS13480	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPT03_RS13495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPT03_RS13500	COG3022	response to hydroperoxide
HPT03_RS13515	COG0083	homoserine kinase activity
HPT03_RS13525	COG0745	RESPONSE REGULATOR receiver
HPT03_RS13530	COG3045	CreA protein
HPT03_RS13535	COG3708	Transcriptional regulator
HPT03_RS13535	COG2207	Transcriptional regulator
HPT03_RS13540	COG0406	alpha-ribazole phosphatase activity
HPT03_RS13545	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HPT03_RS13550	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPT03_RS13555	COG0741	lytic transglycosylase activity
HPT03_RS13560	COG0488	(ABC) transporter
HPT03_RS13570	COG1595	DNA-templated transcription, initiation
HPT03_RS13580	COG4771	TonB-dependent receptor
HPT03_RS13585	COG4178	(ABC) transporter
HPT03_RS13590	COG0612	Peptidase, M16
HPT03_RS13600	COG1902	pentaerythritol trinitrate reductase activity
HPT03_RS13600	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPT03_RS13605	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPT03_RS13610	COG0586	Pfam SNARE associated Golgi protein
HPT03_RS13615	COG4575	ribosome binding
HPT03_RS13620	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HPT03_RS13630	COG2259	Doxx family
HPT03_RS13635	COG0583	DNA-binding transcription factor activity
HPT03_RS13640	COG1741	Belongs to the pirin family
HPT03_RS13650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPT03_RS13660	COG0792	nuclease activity
HPT03_RS13665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPT03_RS13670	COG2823	Periplasmic or secreted lipoprotein
HPT03_RS13675	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPT03_RS13680	COG0830	nickel cation binding
HPT03_RS13685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HPT03_RS13690	COG0804	urea catabolic process
HPT03_RS13695	COG0832	Belongs to the urease beta subunit family
HPT03_RS13700	COG0831	urea catabolic process
HPT03_RS13705	COG0829	nickel cation binding
HPT03_RS13710	COG2207	Transcriptional regulator
HPT03_RS13715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPT03_RS13720	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPT03_RS13725	COG0784	Response regulator, receiver
HPT03_RS13725	COG5002	protein histidine kinase activity
HPT03_RS13725	COG2198	Histidine kinase
HPT03_RS13730	COG0067	glutamate synthase
HPT03_RS13730	COG0070	glutamate synthase
HPT03_RS13730	COG0069	glutamate synthase activity
HPT03_RS13735	COG0493	'glutamate synthase
HPT03_RS13740	COG3069	C4-dicarboxylate transmembrane transporter activity
HPT03_RS13745	COG1473	amidohydrolase
HPT03_RS13755	COG2969	positive regulation of protein catabolic process
HPT03_RS13760	COG0625	glutathione transferase activity
HPT03_RS13765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPT03_RS13770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPT03_RS13775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPT03_RS13780	COG3105	Protein conserved in bacteria
HPT03_RS13785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPT03_RS13790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPT03_RS13810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPT03_RS13815	COG5007	Belongs to the BolA IbaG family
HPT03_RS13825	COG2854	intermembrane phospholipid transfer
HPT03_RS13830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPT03_RS13835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPT03_RS13840	COG1127	ABC transporter
HPT03_RS13845	COG0530	calcium, potassium:sodium antiporter activity
HPT03_RS13850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPT03_RS13850	COG0517	IMP dehydrogenase activity
HPT03_RS13855	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPT03_RS13860	COG3117	lipopolysaccharide transmembrane transporter activity
HPT03_RS13865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPT03_RS13870	COG1137	ATPase activity
HPT03_RS13875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPT03_RS13880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPT03_RS13890	COG1660	Displays ATPase and GTPase activities
HPT03_RS13895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPT03_RS13900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPT03_RS13905	COG0312	modulator of DNA gyrase
HPT03_RS13910	COG3028	Belongs to the UPF0307 family
HPT03_RS13915	COG2732	(Barnase) inhibitor
HPT03_RS13925	COG0312	modulator of DNA gyrase
HPT03_RS13930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPT03_RS13935	COG3164	Protein of unknown function
HPT03_RS13940	COG1530	ribonuclease E activity
HPT03_RS13945	COG0424	maF-like protein
HPT03_RS13950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPT03_RS13955	COG1792	Involved in formation and maintenance of cell shape
HPT03_RS13960	COG1077	Cell shape determining protein MreB Mrl
HPT03_RS13965	COG0604	alcohol dehydrogenase
HPT03_RS13970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPT03_RS13975	COG0511	ligase activity, forming carbon-carbon bonds
HPT03_RS13980	COG0439	Biotin carboxylase
HPT03_RS13985	COG3924	membrane
HPT03_RS13990	COG4145	pantothenate transmembrane transporter activity
HPT03_RS13995	COG2264	protein methyltransferase activity
HPT03_RS14000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPT03_RS14005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPT03_RS14030	COG2807	transmembrane transport
HPT03_RS14035	COG0584	glycerophosphoryl diester phosphodiesterase
HPT03_RS14040	COG1653	transport
HPT03_RS14050	COG0395	ABC-type sugar transport system, permease component
HPT03_RS14055	COG3842	ATPase activity
HPT03_RS14060	COG0501	Belongs to the peptidase M48B family
HPT03_RS14065	COG1846	Transcriptional regulator
HPT03_RS14070	COG2814	Major facilitator Superfamily
HPT03_RS14080	COG1929	Belongs to the glycerate kinase type-1 family
HPT03_RS14090	COG2177	Part of the ABC transporter FtsEX involved in
HPT03_RS14095	COG2884	Cell division ATP-binding protein ftsE
HPT03_RS14100	COG0552	protein localization to endoplasmic reticulum
HPT03_RS14105	COG0742	ribosomal rna small subunit methyltransferase
HPT03_RS14110	COG3776	membrane
HPT03_RS14120	COG3714	YhhN family
HPT03_RS14125	COG2217	Heavy metal translocating P-type atpase
HPT03_RS14150	COG0425	Belongs to the sulfur carrier protein TusA family
HPT03_RS14155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPT03_RS14165	COG0247	lactate metabolic process
HPT03_RS14175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPT03_RS14180	COG2271	Major facilitator Superfamily
HPT03_RS14185	COG0584	glycerophosphoryl diester phosphodiesterase
HPT03_RS14190	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPT03_RS14195	COG1053	succinate dehydrogenase
HPT03_RS14200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPT03_RS14205	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPT03_RS14210	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPT03_RS14215	COG2076	Multidrug Resistance protein
HPT03_RS14220	COG0298	carbon dioxide binding
HPT03_RS14225	COG0375	protein maturation
HPT03_RS14230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPT03_RS14235	COG3604	Transcriptional regulator
HPT03_RS14250	COG2194	sulfuric ester hydrolase activity
HPT03_RS14255	COG1304	FMN binding
HPT03_RS14260	COG2181	nitrate reductase activity
HPT03_RS14265	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPT03_RS14270	COG1140	nitrate reductase beta subunit
HPT03_RS14275	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPT03_RS14280	COG2223	nitrite transmembrane transporter activity
HPT03_RS14285	COG3850	Histidine kinase
HPT03_RS14290	COG2197	response regulator
HPT03_RS14295	COG0583	DNA-binding transcription factor activity
HPT03_RS14310	COG0730	response to heat
HPT03_RS14315	COG4770	biotin carboxylase activity
HPT03_RS14320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPT03_RS14325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPT03_RS14330	COG1914	H( )-stimulated, divalent metal cation uptake system
HPT03_RS14365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPT03_RS14370	COG1739	Uncharacterized protein family UPF0029
HPT03_RS14375	COG0006	proline dipeptidase activity
HPT03_RS14380	COG1024	Enoyl-CoA hydratase
HPT03_RS14380	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPT03_RS14385	COG0183	Belongs to the thiolase family
HPT03_RS14395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPT03_RS14410	COG0805	protein transport
HPT03_RS14415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPT03_RS14420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPT03_RS14430	COG3165	ubiquinone biosynthetic process from chorismate
HPT03_RS14435	COG2226	methyltransferase
HPT03_RS14440	COG1322	Protein conserved in bacteria
HPT03_RS14445	COG0586	Pfam SNARE associated Golgi protein
HPT03_RS14460	COG3753	Protein conserved in bacteria
HPT03_RS14470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPT03_RS14475	COG0583	DNA-binding transcription factor activity
HPT03_RS14485	COG0025	NhaP-type Na H and K H
HPT03_RS14490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPT03_RS14495	COG2252	PERMEase
HPT03_RS14515	COG0440	acetolactate synthase activity
HPT03_RS14520	COG0028	Belongs to the TPP enzyme family
HPT03_RS14540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS14540	COG1263	PTS System
HPT03_RS14545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPT03_RS14555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPT03_RS14560	COG1349	DNA-binding transcription factor activity
HPT03_RS14565	COG1690	Belongs to the RtcB family
HPT03_RS14570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPT03_RS14585	COG0675	Transposase, IS605 OrfB family
HPT03_RS14610	COG2205	protein histidine kinase activity
HPT03_RS14630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPT03_RS14635	COG0795	lipopolysaccharide-transporting ATPase activity
HPT03_RS14640	COG0795	lipopolysaccharide-transporting ATPase activity
HPT03_RS14645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPT03_RS14650	COG2927	DNA polymerase III (CHI subunit)
HPT03_RS14655	COG0525	valine-tRNA ligase activity
HPT03_RS14660	COG0456	acetyltransferase
HPT03_RS14675	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HPT03_RS14680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPT03_RS14690	COG0540	Belongs to the ATCase OTCase family
HPT03_RS14695	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HPT03_RS14700	COG0251	oxidation-reduction process
HPT03_RS14705	COG1328	CTP reductase activity
HPT03_RS14710	COG0602	queuosine metabolic process
HPT03_RS14735	COG2827	Endonuclease containing a URI domain
HPT03_RS14740	COG3153	acetyltransferase
HPT03_RS14745	COG3154	lipid carrier protein
HPT03_RS14750	COG0826	peptidase U32
HPT03_RS14755	COG0826	peptidase U32
HPT03_RS14775	COG3539	Fimbrial protein
HPT03_RS14780	COG3539	Fimbrial protein
HPT03_RS14785	COG3188	usher protein
HPT03_RS14790	COG3121	Chaperone
HPT03_RS14795	COG3539	Fimbrial protein
HPT03_RS14810	COG1566	PFAM secretion protein HlyD family protein
HPT03_RS14815	COG3275	phosphorelay sensor kinase activity
HPT03_RS14835	COG0513	Belongs to the DEAD box helicase family
HPT03_RS14845	COG1185	polyribonucleotide nucleotidyltransferase activity
HPT03_RS14850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPT03_RS14855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPT03_RS14860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPT03_RS14865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPT03_RS14865	COG3064	Membrane
HPT03_RS14870	COG0195	Participates in both transcription termination and antitermination
HPT03_RS14875	COG0779	Required for maturation of 30S ribosomal subunits
HPT03_RS14890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPT03_RS14895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPT03_RS14900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPT03_RS14905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPT03_RS14910	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPT03_RS14915	COG1534	Rna-binding protein
HPT03_RS14925	COG2027	D-alanyl-D-alanine carboxypeptidase
HPT03_RS14930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPT03_RS14935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPT03_RS14940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPT03_RS14945	COG0142	geranyltranstransferase activity
HPT03_RS14960	COG3423	Transcriptional regulator
HPT03_RS14965	COG0039	L-malate dehydrogenase activity
HPT03_RS14970	COG1438	arginine binding
HPT03_RS14975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPT03_RS14980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPT03_RS14985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPT03_RS15005	COG2105	PFAM AIG2 family protein
HPT03_RS15010	COG2911	Protein conserved in bacteria
HPT03_RS15015	COG0729	surface antigen
HPT03_RS15020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPT03_RS15025	COG1253	flavin adenine dinucleotide binding
HPT03_RS15035	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPT03_RS15045	COG0545	Peptidyl-prolyl cis-trans isomerase
HPT03_RS15050	COG1012	belongs to the aldehyde dehydrogenase family
HPT03_RS15055	COG0675	Transposase, IS605 OrfB family
HPT03_RS15065	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPT03_RS15070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPT03_RS15075	COG0254	rRNA binding
HPT03_RS15080	COG3061	Opacity-associated protein A
HPT03_RS15085	COG0359	binds to the 23S rRNA
HPT03_RS15090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPT03_RS15095	COG2965	DNA replication, synthesis of RNA primer
HPT03_RS15100	COG0360	Binds together with S18 to 16S ribosomal RNA
HPT03_RS15105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPT03_RS15110	COG0557	exoribonuclease II activity
HPT03_RS15115	COG1959	2 iron, 2 sulfur cluster binding
HPT03_RS15120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPT03_RS15125	COG0330	HflC and HflK could
HPT03_RS15130	COG0330	HflC and HflK could
HPT03_RS15135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPT03_RS15140	COG1923	regulation of RNA biosynthetic process
HPT03_RS15145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPT03_RS15150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPT03_RS15155	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPT03_RS15160	COG0802	atpase or kinase
HPT03_RS15165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPT03_RS15195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPT03_RS15200	COG1162	GTPase activity
HPT03_RS15205	COG0688	phosphatidylethanolamine metabolic process
HPT03_RS15210	COG3264	Mechanosensitive ion channel
HPT03_RS15210	COG1511	domain protein
HPT03_RS15220	COG3539	Fimbrial protein
HPT03_RS15225	COG3121	Chaperone
HPT03_RS15230	COG3188	usher protein
HPT03_RS15245	COG0675	Transposase, IS605 OrfB family
HPT03_RS15250	COG0561	phosphatase activity
HPT03_RS15255	COG2267	carboxylic ester hydrolase activity
HPT03_RS15270	COG2050	protein possibly involved in aromatic compounds catabolism
HPT03_RS15275	COG2962	Rard protein
HPT03_RS15285	COG0210	DNA helicase
HPT03_RS15290	COG1011	Hydrolase
HPT03_RS15305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPT03_RS15310	COG5567	small periplasmic lipoprotein
HPT03_RS15315	COG1965	Belongs to the frataxin family
HPT03_RS15325	COG0181	hydroxymethylbilane synthase activity
HPT03_RS15335	COG2959	enzyme of heme biosynthesis
HPT03_RS15340	COG3071	HemY protein
HPT03_RS15370	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPT03_RS15380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPT03_RS15385	COG2244	polysaccharide biosynthetic process
HPT03_RS15390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPT03_RS15395	COG0456	acetyltransferase
HPT03_RS15400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPT03_RS15405	COG1088	dTDP-glucose 4,6-dehydratase activity
HPT03_RS15410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPT03_RS15415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPT03_RS15425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPT03_RS15430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPT03_RS15435	COG3118	belongs to the thioredoxin family
HPT03_RS15440	COG0513	Belongs to the DEAD box helicase family
HPT03_RS15445	COG0248	Ppx GppA phosphatase
HPT03_RS15450	COG0210	DNA helicase
HPT03_RS15460	COG3041	Addiction module toxin RelE StbE family
HPT03_RS15465	COG0675	Transposase, IS605 OrfB family
HPT03_RS15475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPT03_RS15490	COG0129	dihydroxy-acid dehydratase activity
HPT03_RS15500	COG3978	acetolactate synthase activity
HPT03_RS15515	COG0606	chelatase, subunit chli
HPT03_RS15520	COG3085	chromosome segregation
HPT03_RS15525	COG0583	DNA-binding transcription factor activity
HPT03_RS15565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPT03_RS15575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPT03_RS15580	COG0009	L-threonylcarbamoyladenylate synthase
HPT03_RS15585	COG0551	DNA topoisomerase type I activity
HPT03_RS15590	COG0758	DNA mediated transformation
HPT03_RS15595	COG0242	peptide deformylase activity
HPT03_RS15600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPT03_RS15605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPT03_RS15605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPT03_RS15610	COG0569	domain protein
HPT03_RS15615	COG1970	mechanosensitive ion channel activity
HPT03_RS15620	COG3036	rescue of stalled ribosome
HPT03_RS15625	COG0789	Transcriptional regulator
HPT03_RS15630	COG0203	ribosomal protein L17
HPT03_RS15640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPT03_RS15650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPT03_RS15655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPT03_RS15660	COG0201	protein transport
HPT03_RS15665	COG0200	Binds to the 23S rRNA
HPT03_RS15670	COG1841	ribosomal large subunit assembly
HPT03_RS15675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPT03_RS15680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPT03_RS15685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPT03_RS15690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPT03_RS15695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPT03_RS15700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPT03_RS15705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPT03_RS15710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPT03_RS15715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPT03_RS15720	COG0255	Belongs to the universal ribosomal protein uL29 family
HPT03_RS15725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPT03_RS15735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPT03_RS15740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPT03_RS15745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPT03_RS15750	COG0089	rRNA binding
HPT03_RS15755	COG0088	Forms part of the polypeptide exit tunnel
HPT03_RS15760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPT03_RS15765	COG0051	transcription antitermination factor activity, RNA binding
HPT03_RS15805	COG1072	(Pantothenic acid kinase))
HPT03_RS15815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPT03_RS15850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPT03_RS15855	COG4206	TonB-dependent receptor
HPT03_RS15860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPT03_RS15875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPT03_RS15885	COG0165	Argininosuccinate lyase
HPT03_RS15890	COG0137	argininosuccinate synthase activity
HPT03_RS15895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPT03_RS15900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPT03_RS15905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPT03_RS15910	COG0028	Belongs to the TPP enzyme family
HPT03_RS15930	COG0583	DNA-binding transcription factor activity
HPT03_RS15935	COG0477	Major facilitator Superfamily
HPT03_RS15945	COG1216	Glycosyl transferase, family 2
HPT03_RS15950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPT03_RS15960	COG2862	Uncharacterized protein family, UPF0114
HPT03_RS15965	COG0460	homoserine dehydrogenase
HPT03_RS15965	COG0527	aspartate kinase activity
HPT03_RS15970	COG0626	cystathionine gamma-synthase activity
HPT03_RS15975	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPT03_RS15985	COG0254	rRNA binding
HPT03_RS15990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPT03_RS15995	COG1609	Transcriptional regulator
HPT03_RS16000	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPT03_RS16005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPT03_RS16010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPT03_RS16015	COG1575	Belongs to the MenA family. Type 1 subfamily
HPT03_RS16020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPT03_RS16025	COG3074	FtsZ-dependent cytokinesis
HPT03_RS16035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPT03_RS16040	COG2814	Major facilitator Superfamily
HPT03_RS16045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPT03_RS16050	COG3152	Membrane
HPT03_RS16060	COG0149	triose-phosphate isomerase activity
HPT03_RS16065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPT03_RS16070	COG0205	6-phosphofructokinase activity
HPT03_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS16080	COG3678	ATP-independent chaperone mediated protein folding
HPT03_RS16085	COG0745	RESPONSE REGULATOR receiver
HPT03_RS16090	COG2205	protein histidine kinase activity
HPT03_RS16105	COG3475	LICD family
HPT03_RS16110	COG0438	transferase activity, transferring glycosyl groups
HPT03_RS16120	COG1216	Glycosyl transferase, family 2
HPT03_RS16125	COG1216	Glycosyl transferase, family 2
HPT03_RS16130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPT03_RS16145	COG2194	sulfuric ester hydrolase activity
HPT03_RS16150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPT03_RS16155	COG1216	Glycosyl transferase, family 2
HPT03_RS16160	COG1045	serine acetyltransferase
HPT03_RS16165	COG1045	serine acetyltransferase
HPT03_RS16175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPT03_RS16180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPT03_RS16190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPT03_RS16195	COG4942	peptidase
HPT03_RS16200	COG2861	carbohydrate metabolic process
HPT03_RS16210	COG1063	alcohol dehydrogenase
HPT03_RS16220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPT03_RS16235	COG1442	glycosyl transferase family 8
HPT03_RS16235	COG1216	Glycosyl transferase, family 2
HPT03_RS16240	COG0859	PFAM glycosyl transferase family 9
HPT03_RS16255	COG0438	transferase activity, transferring glycosyl groups
HPT03_RS16265	COG0859	PFAM glycosyl transferase family 9
HPT03_RS16270	COG1519	Transferase
HPT03_RS16280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPT03_RS16285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPT03_RS16300	COG0297	glycogen (starch) synthase activity
HPT03_RS16310	COG0438	transferase activity, transferring glycosyl groups
HPT03_RS16315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPT03_RS16320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPT03_RS16325	COG2003	Belongs to the UPF0758 family
HPT03_RS16330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPT03_RS16335	COG0756	dUTP diphosphatase activity
HPT03_RS16340	COG1309	transcriptional regulator
HPT03_RS16345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPT03_RS16350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPT03_RS16355	COG1561	YicC-like family, N-terminal region
HPT03_RS16375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPT03_RS16395	COG4106	trans-aconitate 2-methyltransferase activity
HPT03_RS16400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPT03_RS16405	COG0187	DNA topoisomerase II activity
HPT03_RS16410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPT03_RS16420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPT03_RS16425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPT03_RS16430	COG0594	ribonuclease P activity
HPT03_RS16435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPT03_RS16440	COG0706	membrane insertase activity
HPT03_RS16445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPT03_RS16455	COG3550	peptidyl-serine autophosphorylation
HPT03_RS16495	COG0583	DNA-binding transcription factor activity
HPT03_RS16500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPT03_RS16515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPT03_RS16525	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS16530	COG2864	formate dehydrogenase
HPT03_RS16535	COG3058	Necessary for formate dehydrogenase activity
HPT03_RS16540	COG1921	L-seryl-tRNASec selenium transferase activity
HPT03_RS16545	COG3276	selenocysteine insertion sequence binding
HPT03_RS16550	COG1368	sulfuric ester hydrolase activity
HPT03_RS16555	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPT03_RS16560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPT03_RS16565	COG3706	GGDEF domain
HPT03_RS16575	COG0457	Tetratricopeptide repeat
HPT03_RS16585	COG1215	transferase activity, transferring glycosyl groups
HPT03_RS16595	COG1940	carbohydrate kinase activity
HPT03_RS16605	COG3111	PFAM Bacterial OB fold (BOF) protein
HPT03_RS16630	COG3188	usher protein
HPT03_RS16665	COG1288	antiporter activity
HPT03_RS16675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPT03_RS16700	COG0675	Transposase, IS605 OrfB family
HPT03_RS16710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPT03_RS16715	COG1840	ABC-type Fe3 transport system, periplasmic component
HPT03_RS16720	COG1178	ABC-type Fe3 transport system permease component
HPT03_RS16725	COG3842	ATPase activity
HPT03_RS16780	COG4221	oxidoreductase activity
HPT03_RS16965	COG3344	reverse transcriptase
HPT03_RS17015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPT03_RS17020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPT03_RS17025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPT03_RS17030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPT03_RS17035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPT03_RS17040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPT03_RS17045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPT03_RS17050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPT03_RS17060	COG0356	it plays a direct role in the translocation of protons across the membrane
HPT03_RS17065	COG3312	ion transport
HPT03_RS17070	COG0357	Ribosomal RNA small subunit methyltransferase G
HPT03_RS17075	COG0445	tRNA wobble uridine modification
HPT03_RS17080	COG0716	FMN binding
HPT03_RS17085	COG1522	sequence-specific DNA binding
HPT03_RS17090	COG2502	aspartate--ammonia ligase
HPT03_RS17095	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPT03_RS17100	COG0714	Associated with various cellular activities
HPT03_RS17105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPT03_RS17110	COG0477	Major facilitator Superfamily
HPT03_RS17115	COG2186	Transcriptional regulator
HPT03_RS17140	COG0247	lactate metabolic process
HPT03_RS17145	COG1139	Iron-sulfur cluster binding protein
HPT03_RS17150	COG1556	Lactate utilization protein
HPT03_RS17155	COG2194	sulfuric ester hydrolase activity
HPT03_RS17160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPT03_RS17165	COG3162	membrane
HPT03_RS17170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPT03_RS17175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPT03_RS17180	COG2258	MOSC domain
HPT03_RS17190	COG0675	Transposase, IS605 OrfB family
HPT03_RS17195	COG0180	Tryptophanyl-tRNA synthetase
HPT03_RS17200	COG0546	phosphoglycolate phosphatase activity
HPT03_RS17205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPT03_RS17220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPT03_RS17225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPT03_RS17230	COG4796	Type ii and iii secretion system protein
HPT03_RS17250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPT03_RS17260	COG0494	nUDIX hydrolase
HPT03_RS17270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPT03_RS17275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPT03_RS17280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPT03_RS17285	COG1741	Belongs to the pirin family
HPT03_RS17295	COG2081	HI0933 family
HPT03_RS17300	COG0306	phosphate transporter
HPT03_RS17310	COG0589	response to stress
HPT03_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS17325	COG0742	ribosomal rna small subunit methyltransferase
HPT03_RS17370	COG3188	usher protein
HPT03_RS17410	COG3501	Rhs element vgr protein
HPT03_RS17425	COG3122	Protein conserved in bacteria
HPT03_RS17430	COG0564	pseudouridine synthase activity
HPT03_RS17435	COG1278	Cold shock
HPT03_RS17440	COG1737	Transcriptional regulator
HPT03_RS17445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPT03_RS17445	COG1263	PTS System
HPT03_RS17450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPT03_RS17455	COG0733	neurotransmitter:sodium symporter activity
HPT03_RS17460	COG3383	formate dehydrogenase (NAD+) activity
HPT03_RS17470	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPT03_RS17470	COG2755	lipolytic protein G-D-S-L family
HPT03_RS17475	COG1285	pathogenesis
HPT03_RS17480	COG2211	Major facilitator Superfamily
HPT03_RS17490	COG1609	Transcriptional regulator
HPT03_RS17495	COG3302	dmso reductase anchor subunit
HPT03_RS17500	COG0437	4 iron, 4 sulfur cluster binding
HPT03_RS17505	COG0243	molybdopterin cofactor binding
HPT03_RS17515	COG0531	amino acid
HPT03_RS17520	COG1982	Orn Lys Arg decarboxylase major
HPT03_RS17525	COG0531	amino acid
HPT03_RS17540	COG4604	ABC transporter, ATP-binding protein
HPT03_RS17545	COG4605	iron ion homeostasis
HPT03_RS17550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPT03_RS17555	COG4607	ABC-type enterochelin transport system periplasmic component
HPT03_RS17560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPT03_RS17565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPT03_RS17570	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPT03_RS17575	COG2169	Transcriptional regulator
HPT03_RS17575	COG1917	Cupin 2, conserved barrel domain protein
HPT03_RS17580	COG1486	melibiose metabolic process
HPT03_RS17585	COG3394	polysaccharide catabolic process
HPT03_RS17600	COG1073	alpha beta
HPT03_RS17600	COG2226	methyltransferase
HPT03_RS17605	COG0747	negative chemotaxis
HPT03_RS17610	COG0601	transmembrane transport
HPT03_RS17625	COG1124	(ABC) transporter
HPT03_RS17645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPT03_RS17685	COG3189	MarR family transcriptional regulator
HPT03_RS17690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPT03_RS17695	COG1349	DNA-binding transcription factor activity
HPT03_RS17700	COG0705	Rhomboid family
HPT03_RS17705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPT03_RS17710	COG0316	Belongs to the HesB IscA family
HPT03_RS17710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPT03_RS17715	COG1040	competence protein
HPT03_RS17720	COG2267	carboxylic ester hydrolase activity
HPT03_RS17735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPT03_RS17740	COG1918	ferrous iron import across plasma membrane
HPT03_RS17760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPT03_RS17765	COG2252	PERMEase
HPT03_RS17775	COG0736	holo-[acyl-carrier-protein] synthase activity
HPT03_RS17780	COG1028	Short-chain dehydrogenase reductase Sdr
HPT03_RS17785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPT03_RS17790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPT03_RS17795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPT03_RS17800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPT03_RS17815	COG1136	(ABC) transporter
HPT03_RS17840	COG0765	amino acid transport
HPT03_RS17850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPT03_RS17855	COG0704	Plays a role in the regulation of phosphate uptake
HPT03_RS17865	COG0581	inorganic phosphate transmembrane transporter activity
HPT03_RS17870	COG0573	inorganic phosphate transmembrane transporter activity
HPT03_RS17875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPT03_RS17880	COG2205	protein histidine kinase activity
HPT03_RS17885	COG0745	RESPONSE REGULATOR receiver
HPT03_RS17890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPT03_RS17895	COG2183	response to ionizing radiation
HPT03_RS17940	COG1011	Hydrolase
HPT03_RS17945	COG1490	D-aminoacyl-tRNA deacylase activity
HPT03_RS17950	COG0456	acetyltransferase
HPT03_RS17955	COG1187	pseudouridine synthase activity
HPT03_RS17965	COG2982	Protein involved in outer membrane biogenesis
HPT03_RS17970	COG2233	PERMEase
HPT03_RS17975	COG0786	glutamate:sodium symporter activity
HPT03_RS17980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPT03_RS17985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPT03_RS17990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPT03_RS17995	COG1758	RNA polymerase activity
HPT03_RS18000	COG0194	GDP metabolic process
HPT03_RS18005	COG2860	membrane
HPT03_RS18010	COG0823	Involved in the tonB-independent uptake of proteins
HPT03_RS18025	COG0751	glycine-tRNA ligase activity
HPT03_RS18030	COG0752	glycyl-tRNA synthetase alpha subunit
HPT03_RS18035	COG2818	Glycosylase
HPT03_RS18070	COG3121	Chaperone
HPT03_RS18080	COG0569	domain protein
HPT03_RS18080	COG2985	domain, Protein
HPT03_RS18085	COG5645	(Lipo)protein
HPT03_RS18100	COG2831	hemolysin activation secretion protein
HPT03_RS18105	COG0747	negative chemotaxis
HPT03_RS18110	COG0601	transmembrane transport
HPT03_RS18115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPT03_RS18120	COG0444	Belongs to the ABC transporter superfamily
HPT03_RS18125	COG4608	Belongs to the ABC transporter superfamily
HPT03_RS18135	COG2200	EAL domain
HPT03_RS18135	COG2199	diguanylate cyclase activity
HPT03_RS18145	COG1942	4-Oxalocrotonate Tautomerase
HPT03_RS18150	COG1295	ribonuclease BN
HPT03_RS18160	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPT03_RS18165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPT03_RS18180	COG0366	Alpha amylase catalytic
HPT03_RS18185	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPT03_RS18190	COG0746	molybdenum cofactor guanylyltransferase activity
HPT03_RS18195	COG3084	Protein conserved in bacteria
HPT03_RS18200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPT03_RS18205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPT03_RS18215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPT03_RS18215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPT03_RS18220	COG0242	peptide deformylase activity
HPT03_RS18230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPT03_RS18240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPT03_RS18245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPT03_RS18250	COG1765	OsmC-like protein
HPT03_RS18255	COG3954	Phosphoribulokinase
HPT03_RS18260	COG3089	Belongs to the UPF0270 family
HPT03_RS18265	COG0429	hydrolase of the alpha beta-hydrolase fold
HPT03_RS18280	COG0840	transmembrane signaling receptor activity
HPT03_RS18285	COG0840	transmembrane signaling receptor activity
HPT03_RS18290	COG0840	transmembrane signaling receptor activity
HPT03_RS18295	COG0488	(ABC) transporter
HPT03_RS18300	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPT03_RS18310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HPT03_RS18315	COG1047	Peptidyl-prolyl cis-trans
HPT03_RS18320	COG2900	Belongs to the SlyX family
HPT03_RS18325	COG0545	Peptidyl-prolyl cis-trans isomerase
HPT03_RS18335	COG2964	Protein conserved in bacteria
HPT03_RS18340	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPT03_RS18345	COG2923	Belongs to the DsrF TusC family
HPT03_RS18355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPT03_RS18360	COG0049	tRNA binding
HPT03_RS18365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPT03_RS18380	COG0250	Participates in transcription elongation, termination and antitermination
HPT03_RS18385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPT03_RS18390	COG0081	regulation of translation
HPT03_RS18395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPT03_RS18400	COG0222	ribosome binding
HPT03_RS18405	COG0085	RNA polymerase activity
HPT03_RS18410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPT03_RS18415	COG5464	transposase or invertase
HPT03_RS18425	COG2022	thiamine diphosphate biosynthetic process
HPT03_RS18430	COG2104	thiamine diphosphate biosynthetic process
HPT03_RS18435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPT03_RS18440	COG0352	thiamine-phosphate diphosphorylase activity
HPT03_RS18445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPT03_RS18455	COG2816	NAD+ diphosphatase activity
HPT03_RS18460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPT03_RS18465	COG1515	deoxyribonuclease V activity
HPT03_RS18470	COG3068	Protein conserved in bacteria
HPT03_RS18485	COG0151	Belongs to the GarS family
HPT03_RS18490	COG0138	bifunctional purine biosynthesis protein purh
HPT03_RS18520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HPT03_RS18530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPT03_RS18535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPT03_RS18540	COG2224	Isocitrate lyase
HPT03_RS18550	COG0800	Aldolase
HPT03_RS18555	COG0129	dihydroxy-acid dehydratase activity
HPT03_RS18565	COG0646	methionine synthase
HPT03_RS18565	COG1410	methionine synthase
HPT03_RS18580	COG0527	aspartate kinase activity
HPT03_RS18585	COG0166	Belongs to the GPI family
HPT03_RS18590	COG3161	chorismate lyase activity
HPT03_RS18595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPT03_RS18600	COG2937	Belongs to the GPAT DAPAT family
HPT03_RS18605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPT03_RS18610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPT03_RS18615	COG0735	belongs to the Fur family
HPT03_RS18625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPT03_RS18630	COG0814	amino acid
HPT03_RS18640	COG1448	Aminotransferase
HPT03_RS18660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPT03_RS18680	COG1177	transmembrane transport
HPT03_RS18700	COG3539	Fimbrial protein
HPT03_RS18705	COG3188	usher protein
HPT03_RS18725	COG2873	o-acetylhomoserine