locus-tag	class	description
I0U46_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I0U46_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0U46_RS00020	COG0187	DNA topoisomerase II activity
I0U46_RS00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0U46_RS00030	COG4106	trans-aconitate 2-methyltransferase activity
I0U46_RS00050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I0U46_RS00085	COG3012	SEC-C Motif Domain Protein
I0U46_RS00160	COG2856	Zn peptidase
I0U46_RS00180	COG1561	YicC-like family, N-terminal region
I0U46_RS00185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I0U46_RS00190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I0U46_RS00195	COG1309	transcriptional regulator
I0U46_RS00200	COG0756	dUTP diphosphatase activity
I0U46_RS00205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0U46_RS00210	COG2003	Belongs to the UPF0758 family
I0U46_RS00215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I0U46_RS00220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I0U46_RS00225	COG0438	transferase activity, transferring glycosyl groups
I0U46_RS00235	COG0297	glycogen (starch) synthase activity
I0U46_RS00250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I0U46_RS00255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I0U46_RS00265	COG1519	Transferase
I0U46_RS00275	COG0438	transferase activity, transferring glycosyl groups
I0U46_RS00280	COG0859	PFAM glycosyl transferase family 9
I0U46_RS00305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0U46_RS00310	COG0156	8-amino-7-oxononanoate synthase activity
I0U46_RS00315	COG1063	alcohol dehydrogenase
I0U46_RS00320	COG2861	carbohydrate metabolic process
I0U46_RS00325	COG4942	peptidase
I0U46_RS00330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0U46_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0U46_RS00345	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I0U46_RS00355	COG1045	serine acetyltransferase
I0U46_RS00360	COG1045	serine acetyltransferase
I0U46_RS00365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I0U46_RS00370	COG2194	sulfuric ester hydrolase activity
I0U46_RS00380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0U46_RS00385	COG1216	Glycosyl transferase, family 2
I0U46_RS00390	COG1216	Glycosyl transferase, family 2
I0U46_RS00400	COG0438	transferase activity, transferring glycosyl groups
I0U46_RS00405	COG3475	LICD family
I0U46_RS00430	COG2205	protein histidine kinase activity
I0U46_RS00435	COG0745	RESPONSE REGULATOR receiver
I0U46_RS00440	COG3678	ATP-independent chaperone mediated protein folding
I0U46_RS00450	COG0438	transferase activity, transferring glycosyl groups
I0U46_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS00460	COG0205	6-phosphofructokinase activity
I0U46_RS00465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I0U46_RS00470	COG0149	triose-phosphate isomerase activity
I0U46_RS00480	COG3152	Membrane
I0U46_RS00485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0U46_RS00490	COG2814	Major facilitator Superfamily
I0U46_RS00495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I0U46_RS00505	COG3074	FtsZ-dependent cytokinesis
I0U46_RS00510	COG3550	peptidyl-serine autophosphorylation
I0U46_RS00515	COG1396	sequence-specific DNA binding
I0U46_RS00520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I0U46_RS00525	COG1575	Belongs to the MenA family. Type 1 subfamily
I0U46_RS00530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I0U46_RS00535	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I0U46_RS00540	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I0U46_RS00545	COG1609	Transcriptional regulator
I0U46_RS00550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I0U46_RS00555	COG0254	rRNA binding
I0U46_RS00560	COG3550	peptidyl-serine autophosphorylation
I0U46_RS00565	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I0U46_RS00570	COG0626	cystathionine gamma-synthase activity
I0U46_RS00575	COG0460	homoserine dehydrogenase
I0U46_RS00575	COG0527	aspartate kinase activity
I0U46_RS00580	COG2862	Uncharacterized protein family, UPF0114
I0U46_RS00590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I0U46_RS00595	COG1216	Glycosyl transferase, family 2
I0U46_RS00605	COG0477	Major facilitator Superfamily
I0U46_RS00610	COG0583	DNA-binding transcription factor activity
I0U46_RS00630	COG0028	Belongs to the TPP enzyme family
I0U46_RS00635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0U46_RS00640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I0U46_RS00645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I0U46_RS00650	COG0137	argininosuccinate synthase activity
I0U46_RS00655	COG0165	Argininosuccinate lyase
I0U46_RS00665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0U46_RS00680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I0U46_RS00685	COG4206	TonB-dependent receptor
I0U46_RS00690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I0U46_RS00725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I0U46_RS00735	COG1072	(Pantothenic acid kinase))
I0U46_RS00775	COG0051	transcription antitermination factor activity, RNA binding
I0U46_RS00780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I0U46_RS00785	COG0088	Forms part of the polypeptide exit tunnel
I0U46_RS00790	COG0089	rRNA binding
I0U46_RS00795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I0U46_RS00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I0U46_RS00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I0U46_RS00815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I0U46_RS00820	COG0255	Belongs to the universal ribosomal protein uL29 family
I0U46_RS00825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I0U46_RS00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I0U46_RS00835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I0U46_RS00840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I0U46_RS00845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I0U46_RS00850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I0U46_RS00855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I0U46_RS00860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I0U46_RS00865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I0U46_RS00870	COG1841	ribosomal large subunit assembly
I0U46_RS00875	COG0200	Binds to the 23S rRNA
I0U46_RS00880	COG0201	protein transport
I0U46_RS00885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I0U46_RS00890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I0U46_RS00900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I0U46_RS00910	COG0203	ribosomal protein L17
I0U46_RS00915	COG0789	Transcriptional regulator
I0U46_RS00920	COG3036	rescue of stalled ribosome
I0U46_RS00925	COG1970	mechanosensitive ion channel activity
I0U46_RS00930	COG0569	domain protein
I0U46_RS00935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I0U46_RS00935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0U46_RS00940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0U46_RS00945	COG0242	peptide deformylase activity
I0U46_RS00950	COG0758	DNA mediated transformation
I0U46_RS00955	COG0551	DNA topoisomerase type I activity
I0U46_RS00960	COG0009	L-threonylcarbamoyladenylate synthase
I0U46_RS00965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I0U46_RS00975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I0U46_RS01015	COG0583	DNA-binding transcription factor activity
I0U46_RS01020	COG3085	chromosome segregation
I0U46_RS01025	COG0606	chelatase, subunit chli
I0U46_RS01040	COG3978	acetolactate synthase activity
I0U46_RS01050	COG0129	dihydroxy-acid dehydratase activity
I0U46_RS01065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I0U46_RS01075	COG0675	Transposase, IS605 OrfB family
I0U46_RS01080	COG3041	Addiction module toxin RelE StbE family
I0U46_RS01090	COG0210	DNA helicase
I0U46_RS01095	COG0248	Ppx GppA phosphatase
I0U46_RS01100	COG0513	Belongs to the DEAD box helicase family
I0U46_RS01105	COG3118	belongs to the thioredoxin family
I0U46_RS01110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I0U46_RS01115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0U46_RS01125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I0U46_RS01130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I0U46_RS01135	COG1088	dTDP-glucose 4,6-dehydratase activity
I0U46_RS01140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I0U46_RS01145	COG0456	acetyltransferase
I0U46_RS01150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0U46_RS01155	COG2244	polysaccharide biosynthetic process
I0U46_RS01160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I0U46_RS01170	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I0U46_RS01200	COG3071	HemY protein
I0U46_RS01205	COG2959	enzyme of heme biosynthesis
I0U46_RS01215	COG0181	hydroxymethylbilane synthase activity
I0U46_RS01225	COG1965	Belongs to the frataxin family
I0U46_RS01230	COG5567	small periplasmic lipoprotein
I0U46_RS01235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I0U46_RS01250	COG1011	Hydrolase
I0U46_RS01255	COG0210	DNA helicase
I0U46_RS01265	COG2962	Rard protein
I0U46_RS01270	COG2050	protein possibly involved in aromatic compounds catabolism
I0U46_RS01285	COG2267	carboxylic ester hydrolase activity
I0U46_RS01290	COG0561	phosphatase activity
I0U46_RS01300	COG3188	usher protein
I0U46_RS01305	COG3121	Chaperone
I0U46_RS01310	COG3539	Fimbrial protein
I0U46_RS01320	COG1511	domain protein
I0U46_RS01320	COG3264	Mechanosensitive ion channel
I0U46_RS01325	COG0688	phosphatidylethanolamine metabolic process
I0U46_RS01330	COG1162	GTPase activity
I0U46_RS01335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I0U46_RS01365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I0U46_RS01370	COG0802	atpase or kinase
I0U46_RS01375	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0U46_RS01380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I0U46_RS01385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I0U46_RS01390	COG1923	regulation of RNA biosynthetic process
I0U46_RS01395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0U46_RS01400	COG0330	HflC and HflK could
I0U46_RS01405	COG0330	HflC and HflK could
I0U46_RS01410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I0U46_RS01415	COG1959	2 iron, 2 sulfur cluster binding
I0U46_RS01420	COG0557	exoribonuclease II activity
I0U46_RS01425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0U46_RS01430	COG0360	Binds together with S18 to 16S ribosomal RNA
I0U46_RS01435	COG2965	DNA replication, synthesis of RNA primer
I0U46_RS01440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I0U46_RS01445	COG0359	binds to the 23S rRNA
I0U46_RS01450	COG3061	Opacity-associated protein A
I0U46_RS01455	COG0254	rRNA binding
I0U46_RS01460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I0U46_RS01465	COG3443	Belongs to the bacterial solute-binding protein 9 family
I0U46_RS01475	COG0675	Transposase, IS605 OrfB family
I0U46_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
I0U46_RS01485	COG0545	Peptidyl-prolyl cis-trans isomerase
I0U46_RS01495	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I0U46_RS01505	COG1253	flavin adenine dinucleotide binding
I0U46_RS01510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0U46_RS01515	COG0729	surface antigen
I0U46_RS01520	COG2911	Protein conserved in bacteria
I0U46_RS01525	COG2105	PFAM AIG2 family protein
I0U46_RS01545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I0U46_RS01550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I0U46_RS01555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I0U46_RS01560	COG1438	arginine binding
I0U46_RS01565	COG0039	L-malate dehydrogenase activity
I0U46_RS01570	COG3423	Transcriptional regulator
I0U46_RS01585	COG0142	geranyltranstransferase activity
I0U46_RS01590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I0U46_RS01595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I0U46_RS01600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I0U46_RS01605	COG2027	D-alanyl-D-alanine carboxypeptidase
I0U46_RS01615	COG1534	Rna-binding protein
I0U46_RS01620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I0U46_RS01625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0U46_RS01630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I0U46_RS01635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0U46_RS01640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0U46_RS01655	COG0779	Required for maturation of 30S ribosomal subunits
I0U46_RS01660	COG0195	Participates in both transcription termination and antitermination
I0U46_RS01665	COG3064	Membrane
I0U46_RS01665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I0U46_RS01670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I0U46_RS01675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I0U46_RS01680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I0U46_RS01685	COG1185	polyribonucleotide nucleotidyltransferase activity
I0U46_RS01695	COG0513	Belongs to the DEAD box helicase family
I0U46_RS01700	COG2964	Protein conserved in bacteria
I0U46_RS01710	COG0251	oxidation-reduction process
I0U46_RS01715	COG2271	Major facilitator Superfamily
I0U46_RS01745	COG3275	phosphorelay sensor kinase activity
I0U46_RS01750	COG1566	PFAM secretion protein HlyD family protein
I0U46_RS01765	COG3539	Fimbrial protein
I0U46_RS01770	COG3121	Chaperone
I0U46_RS01775	COG3188	usher protein
I0U46_RS01780	COG3539	Fimbrial protein
I0U46_RS01785	COG3539	Fimbrial protein
I0U46_RS01790	COG3539	Fimbrial protein
I0U46_RS01795	COG0826	peptidase U32
I0U46_RS01800	COG0826	peptidase U32
I0U46_RS01805	COG3154	lipid carrier protein
I0U46_RS01810	COG3153	acetyltransferase
I0U46_RS01815	COG2827	Endonuclease containing a URI domain
I0U46_RS01840	COG0602	queuosine metabolic process
I0U46_RS01845	COG1328	CTP reductase activity
I0U46_RS01850	COG0251	oxidation-reduction process
I0U46_RS01855	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I0U46_RS01860	COG0540	Belongs to the ATCase OTCase family
I0U46_RS01870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I0U46_RS01880	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I0U46_RS01895	COG0456	acetyltransferase
I0U46_RS01900	COG0525	valine-tRNA ligase activity
I0U46_RS01905	COG2927	DNA polymerase III (CHI subunit)
I0U46_RS01910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I0U46_RS01915	COG0795	lipopolysaccharide-transporting ATPase activity
I0U46_RS01920	COG0795	lipopolysaccharide-transporting ATPase activity
I0U46_RS01925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0U46_RS01935	COG0582	viral genome integration into host DNA
I0U46_RS01985	COG4735	regulation of single-species biofilm formation
I0U46_RS02020	COG1192	Involved in chromosome partitioning
I0U46_RS02035	COG0675	Transposase, IS605 OrfB family
I0U46_RS02045	COG0702	epimerase
I0U46_RS02080	COG3188	usher protein
I0U46_RS02095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I0U46_RS02100	COG0698	ribose 5-phosphate isomerase
I0U46_RS02105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I0U46_RS02110	COG0651	ATP synthesis coupled electron transport
I0U46_RS02115	COG0650	Formate hydrogenlyase subunit 4
I0U46_RS02120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0U46_RS02125	COG4237	Hydrogenase 4 membrane
I0U46_RS02130	COG0651	ATP synthesis coupled electron transport
I0U46_RS02135	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I0U46_RS02135	COG3261	NADH dehydrogenase
I0U46_RS02140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0U46_RS02145	COG3260	NADH ubiquinone oxidoreductase 20
I0U46_RS02155	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I0U46_RS02160	COG1216	Glycosyl transferase, family 2
I0U46_RS02175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0U46_RS02195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I0U46_RS02200	COG1328	CTP reductase activity
I0U46_RS02205	COG3726	membrane protein affecting hemolysin expression
I0U46_RS02210	COG0560	Phosphoserine phosphatase
I0U46_RS02230	COG2382	esterase
I0U46_RS02235	COG1785	Belongs to the alkaline phosphatase family
I0U46_RS02240	COG1283	sodium-dependent phosphate transmembrane transporter activity
I0U46_RS02255	COG2813	Specifically methylates the guanine in position
I0U46_RS02275	COG1401	restriction endodeoxyribonuclease activity
I0U46_RS02290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I0U46_RS02300	COG4667	esterase of the alpha-beta hydrolase superfamily
I0U46_RS02305	COG0084	hydrolase, TatD family'
I0U46_RS02310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0U46_RS02315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I0U46_RS02320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I0U46_RS02325	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I0U46_RS02330	COG0813	purine-nucleoside phosphorylase activity
I0U46_RS02335	COG2851	Citrate transporter
I0U46_RS02345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I0U46_RS02350	COG0469	pyruvate kinase activity
I0U46_RS02355	COG2271	Major facilitator Superfamily
I0U46_RS02365	COG4191	Histidine kinase
I0U46_RS02375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I0U46_RS02375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0U46_RS02375	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I0U46_RS02380	COG1461	Dihydroxyacetone kinase
I0U46_RS02385	COG2376	Dihydroxyacetone kinase
I0U46_RS02440	COG1358	cellular component organization or biogenesis
I0U46_RS02490	COG0840	transmembrane signaling receptor activity
I0U46_RS02495	COG0840	transmembrane signaling receptor activity
I0U46_RS02500	COG0583	DNA-binding transcription factor activity
I0U46_RS02505	COG0243	molybdopterin cofactor binding
I0U46_RS02510	COG1271	oxidase subunit
I0U46_RS02515	COG1294	oxidase, subunit
I0U46_RS02525	COG3781	membrane
I0U46_RS02545	COG0358	DNA primase activity
I0U46_RS02550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I0U46_RS02555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I0U46_RS02560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I0U46_RS02580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I0U46_RS02585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I0U46_RS02590	COG0617	tRNA 3'-terminal CCA addition
I0U46_RS02595	COG4991	sh3 domain protein
I0U46_RS02600	COG3025	triphosphatase activity
I0U46_RS02605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I0U46_RS02610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I0U46_RS02610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I0U46_RS02620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I0U46_RS02625	COG3384	dioxygenase
I0U46_RS02630	COG0754	glutathionylspermidine amidase activity
I0U46_RS02635	COG5463	Belongs to the UPF0441 family
I0U46_RS02640	COG1538	Outer membrane efflux protein
I0U46_RS02645	COG0494	nUDIX hydrolase
I0U46_RS02650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I0U46_RS02655	COG3150	esterase
I0U46_RS02660	COG0187	DNA topoisomerase II activity
I0U46_RS02665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0U46_RS02670	COG0204	Acyl-transferase
I0U46_RS02675	COG2132	Multicopper oxidase
I0U46_RS02695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0U46_RS02700	COG2967	ApaG domain
I0U46_RS02705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I0U46_RS02710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I0U46_RS02715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0U46_RS02720	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I0U46_RS02725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I0U46_RS02730	COG0564	pseudouridine synthase activity
I0U46_RS02735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0U46_RS02740	COG0417	DNA replication proofreading
I0U46_RS02750	COG3311	Transcriptional regulator
I0U46_RS02755	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I0U46_RS02760	COG1178	ABC-type Fe3 transport system permease component
I0U46_RS02765	COG4143	(ABC) transporter
I0U46_RS02770	COG0494	nUDIX hydrolase
I0U46_RS02780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I0U46_RS02785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I0U46_RS02820	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I0U46_RS02825	COG1025	Belongs to the peptidase M16 family
I0U46_RS02830	COG1074	ATP-dependent DNA helicase activity
I0U46_RS02835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0U46_RS02840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I0U46_RS02840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I0U46_RS02845	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0U46_RS02865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I0U46_RS02870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I0U46_RS02875	COG2166	iron-sulfur cluster assembly
I0U46_RS02880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I0U46_RS02885	COG0583	DNA-binding transcription factor activity
I0U46_RS02890	COG2363	Small membrane protein
I0U46_RS02895	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I0U46_RS02900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0U46_RS02905	COG1611	Belongs to the LOG family
I0U46_RS02910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I0U46_RS02910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I0U46_RS02920	COG3098	single-species biofilm formation
I0U46_RS02930	COG1263	PTS System
I0U46_RS02930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS02940	COG0716	FMN binding
I0U46_RS02950	COG2171	N-acyltransferase activity
I0U46_RS02955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I0U46_RS02965	COG0052	Belongs to the universal ribosomal protein uS2 family
I0U46_RS02970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I0U46_RS02975	COG0528	UMP kinase activity
I0U46_RS02980	COG0233	cytoplasmic translational termination
I0U46_RS02985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I0U46_RS02990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I0U46_RS02995	COG0575	Belongs to the CDS family
I0U46_RS03015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0U46_RS03020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0U46_RS03025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0U46_RS03030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0U46_RS03035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I0U46_RS03045	COG0825	malonyl-CoA metabolic process
I0U46_RS03055	COG0037	tRNA processing
I0U46_RS03060	COG4568	rho-dependent transcription termination
I0U46_RS03065	COG3015	lipoprotein NlpE involved in copper resistance
I0U46_RS03070	COG0442	prolyl-tRNA aminoacylation
I0U46_RS03075	COG1720	tRNA m6t6A37 methyltransferase activity
I0U46_RS03085	COG1464	Belongs to the NlpA lipoprotein family
I0U46_RS03090	COG2011	ABC-type metal ion transport system permease component
I0U46_RS03095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0U46_RS03100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I0U46_RS03155	COG0602	queuosine metabolic process
I0U46_RS03160	COG0720	synthase
I0U46_RS03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I0U46_RS03170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0U46_RS03175	COG0175	sulfate reduction
I0U46_RS03180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0U46_RS03180	COG1648	precorrin-2 dehydrogenase activity
I0U46_RS03185	COG0175	sulfate reduction
I0U46_RS03190	COG2895	sulfate adenylyltransferase (ATP) activity
I0U46_RS03205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I0U46_RS03210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I0U46_RS03215	COG0585	pseudouridine synthase activity
I0U46_RS03220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I0U46_RS03225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I0U46_RS03230	COG4942	peptidase
I0U46_RS03230	COG1388	LysM domain
I0U46_RS03240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I0U46_RS03250	COG3711	transcriptional antiterminator
I0U46_RS03255	COG2190	(PTS) system
I0U46_RS03255	COG1263	PTS System
I0U46_RS03255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS03260	COG0613	PHP domain protein
I0U46_RS03330	COG3539	Fimbrial protein
I0U46_RS03355	COG0471	metal ion transport
I0U46_RS03370	COG1335	isochorismatase
I0U46_RS03375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0U46_RS03380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0U46_RS03390	COG0549	Belongs to the carbamate kinase family
I0U46_RS03400	COG0583	DNA-binding transcription factor activity
I0U46_RS03410	COG4589	Belongs to the CDS family
I0U46_RS03425	COG4566	intracellular signal transduction
I0U46_RS03445	COG2962	Rard protein
I0U46_RS03450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I0U46_RS03455	COG0326	Molecular chaperone. Has ATPase activity
I0U46_RS03460	COG0563	adenylate kinase activity
I0U46_RS03465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I0U46_RS03470	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I0U46_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0U46_RS03480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0U46_RS03480	COG4651	solute:proton antiporter activity
I0U46_RS03485	COG0737	Belongs to the 5'-nucleotidase family
I0U46_RS03495	COG3735	TraB family
I0U46_RS03510	COG0789	Transcriptional regulator
I0U46_RS03520	COG0330	HflC and HflK could
I0U46_RS03525	COG3118	belongs to the thioredoxin family
I0U46_RS03530	COG0300	oxidoreductase activity
I0U46_RS03535	COG2755	lipolytic protein G-D-S-L family
I0U46_RS03540	COG4181	ATPase activity
I0U46_RS03545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I0U46_RS03550	COG0668	transmembrane transport
I0U46_RS03560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I0U46_RS03565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I0U46_RS03570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0U46_RS03575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I0U46_RS03580	COG0215	cysteine-tRNA ligase activity
I0U46_RS03585	COG1105	Belongs to the carbohydrate kinase PfkB family
I0U46_RS03590	COG2501	S4 domain
I0U46_RS03595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I0U46_RS03615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0U46_RS03625	COG0640	Transcriptional regulator
I0U46_RS03630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0U46_RS03635	COG0384	phenazine biosynthesis protein PhzF
I0U46_RS03650	COG0800	Aldolase
I0U46_RS03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0U46_RS03670	COG3119	arylsulfatase activity
I0U46_RS03675	COG0641	radical SAM
I0U46_RS03680	COG1349	DNA-binding transcription factor activity
I0U46_RS03690	COG2222	sugar isomerase
I0U46_RS03695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS03700	COG3715	PTS system
I0U46_RS03705	COG3716	PTS system mannose fructose sorbose family IID component
I0U46_RS03710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0U46_RS03710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS03715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I0U46_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS03755	COG3119	arylsulfatase activity
I0U46_RS03765	COG5295	Hep Hag repeat protein
I0U46_RS03775	COG3038	cytochrome b561
I0U46_RS03780	COG2353	YceI-like domain
I0U46_RS03785	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I0U46_RS03790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0U46_RS03805	COG1115	amino acid carrier protein
I0U46_RS03815	COG1151	hydroxylamine reductase activity
I0U46_RS03820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0U46_RS03830	COG2239	Acts as a magnesium transporter
I0U46_RS03845	COG3091	SprT-like family
I0U46_RS03850	COG0640	Transcriptional regulator
I0U46_RS03865	COG0457	Tetratricopeptide repeat
I0U46_RS03865	COG3118	belongs to the thioredoxin family
I0U46_RS03870	COG1215	transferase activity, transferring glycosyl groups
I0U46_RS03880	COG1192	Involved in chromosome partitioning
I0U46_RS03890	COG2194	sulfuric ester hydrolase activity
I0U46_RS03895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I0U46_RS03900	COG1166	arginine decarboxylase activity
I0U46_RS03905	COG0010	Belongs to the arginase family
I0U46_RS03915	COG3657	addiction module killer protein
I0U46_RS03925	COG3066	DNA modification
I0U46_RS03930	COG4533	DNA binding
I0U46_RS03935	COG0066	3-isopropylmalate dehydratase activity
I0U46_RS03940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I0U46_RS03945	COG0473	3-isopropylmalate dehydrogenase activity
I0U46_RS03950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0U46_RS03960	COG1022	Amp-dependent synthetase and ligase
I0U46_RS03970	COG2001	Belongs to the MraZ family
I0U46_RS03975	COG0275	rRNA processing
I0U46_RS03985	COG0768	penicillin binding
I0U46_RS03990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I0U46_RS03995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0U46_RS04000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0U46_RS04010	COG0772	Belongs to the SEDS family
I0U46_RS04015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I0U46_RS04020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I0U46_RS04030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I0U46_RS04035	COG0849	cell division
I0U46_RS04045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I0U46_RS04060	COG0653	protein targeting
I0U46_RS04065	COG0789	Transcriptional regulator
I0U46_RS04090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I0U46_RS04095	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I0U46_RS04100	COG0237	dephospho-CoA kinase activity
I0U46_RS04110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I0U46_RS04115	COG4969	Belongs to the N-Me-Phe pilin family
I0U46_RS04120	COG3023	N-Acetylmuramoyl-L-alanine amidase
I0U46_RS04125	COG2186	Transcriptional regulator
I0U46_RS04130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I0U46_RS04135	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0U46_RS04140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0U46_RS04145	COG1073	alpha beta
I0U46_RS04145	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I0U46_RS04145	COG3064	Membrane
I0U46_RS04165	COG3112	Uncharacterised protein family (UPF0231)
I0U46_RS04175	COG1279	arginine transmembrane transporter activity
I0U46_RS04195	COG0583	DNA-binding transcription factor activity
I0U46_RS04200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I0U46_RS04205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0U46_RS04215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0U46_RS04225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I0U46_RS04235	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I0U46_RS04240	COG3079	Belongs to the UPF0149 family
I0U46_RS04245	COG0006	proline dipeptidase activity
I0U46_RS04250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0U46_RS04255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0U46_RS04260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0U46_RS04265	COG0509	glycine decarboxylation via glycine cleavage system
I0U46_RS04270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I0U46_RS04270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I0U46_RS04280	COG0354	folic acid binding
I0U46_RS04285	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I0U46_RS04295	COG0716	FMN binding
I0U46_RS04305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0U46_RS04310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0U46_RS04320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I0U46_RS04390	COG2841	Protein conserved in bacteria
I0U46_RS04395	COG4574	serine-type endopeptidase inhibitor activity
I0U46_RS04400	COG0589	response to stress
I0U46_RS04405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0U46_RS04415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0U46_RS04420	COG1085	galactose-1-phosphate uridylyltransferase
I0U46_RS04425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I0U46_RS04430	COG2017	converts alpha-aldose to the beta-anomer
I0U46_RS04435	COG1609	Transcriptional regulator
I0U46_RS04445	COG4771	TonB-dependent receptor
I0U46_RS04450	COG2819	hydrolase of the alpha beta superfamily
I0U46_RS04460	COG3738	Protein conserved in bacteria
I0U46_RS04465	COG0727	PFAM Uncharacterised protein family (UPF0153)
I0U46_RS04480	COG1556	Lactate utilization protein
I0U46_RS04485	COG1139	Iron-sulfur cluster binding protein
I0U46_RS04490	COG0247	lactate metabolic process
I0U46_RS04495	COG1620	l-lactate permease
I0U46_RS04500	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0U46_RS04515	COG0579	oxidoreductase
I0U46_RS04540	COG2831	hemolysin activation secretion protein
I0U46_RS04575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0U46_RS04580	COG0697	spore germination
I0U46_RS04600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I0U46_RS04605	COG1479	Protein of unknown function DUF262
I0U46_RS04635	COG0494	nUDIX hydrolase
I0U46_RS04650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I0U46_RS04655	COG2867	negative regulation of translational initiation
I0U46_RS04660	COG2914	Belongs to the UPF0125 (RnfH) family
I0U46_RS04670	COG0497	DNA recombination
I0U46_RS04675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I0U46_RS04680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I0U46_RS04685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I0U46_RS04690	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I0U46_RS04695	COG0513	Belongs to the DEAD box helicase family
I0U46_RS04700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I0U46_RS04705	COG1595	DNA-templated transcription, initiation
I0U46_RS04710	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I0U46_RS04715	COG3026	antisigma factor binding
I0U46_RS04720	COG3086	response to oxidative stress
I0U46_RS04725	COG0481	GTPase activity
I0U46_RS04730	COG0681	Belongs to the peptidase S26 family
I0U46_RS04735	COG0571	ribonuclease III activity
I0U46_RS04740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I0U46_RS04745	COG1381	Involved in DNA repair and RecF pathway recombination
I0U46_RS04750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I0U46_RS04755	COG0736	holo-[acyl-carrier-protein] synthase activity
I0U46_RS04760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I0U46_RS04770	COG3539	Fimbrial protein
I0U46_RS04775	COG3539	Fimbrial protein
I0U46_RS04780	COG3121	Chaperone
I0U46_RS04785	COG3188	usher protein
I0U46_RS04790	COG3539	Fimbrial protein
I0U46_RS04795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I0U46_RS04800	COG0047	phosphoribosylformylglycinamidine synthase activity
I0U46_RS04800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0U46_RS04805	COG2205	protein histidine kinase activity
I0U46_RS04810	COG3170	Tfp pilus assembly protein FimV
I0U46_RS04815	COG2204	response regulator
I0U46_RS04820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I0U46_RS04820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0U46_RS04825	COG0347	Belongs to the P(II) protein family
I0U46_RS04835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0U46_RS04835	COG1017	nitric oxide dioxygenase activity
I0U46_RS04840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I0U46_RS04845	COG2814	Major facilitator Superfamily
I0U46_RS04860	COG0483	inositol monophosphate 1-phosphatase activity
I0U46_RS04865	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I0U46_RS04870	COG1959	2 iron, 2 sulfur cluster binding
I0U46_RS04875	COG1104	cysteine desulfurase activity
I0U46_RS04880	COG0822	iron-sulfur transferase activity
I0U46_RS04885	COG0316	Belongs to the HesB IscA family
I0U46_RS04890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I0U46_RS04895	COG0443	Heat shock 70 kDa protein
I0U46_RS04900	COG0633	Ferredoxin
I0U46_RS04905	COG2975	iron-sulfur cluster assembly
I0U46_RS04910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I0U46_RS04920	COG2373	Large extracellular alpha-helical protein
I0U46_RS04925	COG4953	penicillin-binding protein 1C
I0U46_RS04930	COG0105	UTP biosynthetic process
I0U46_RS04935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I0U46_RS04950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I0U46_RS04955	COG0124	histidyl-tRNA synthetase
I0U46_RS04960	COG2976	Protein conserved in bacteria
I0U46_RS04965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I0U46_RS04970	COG1160	GTP binding
I0U46_RS04980	COG0408	coproporphyrinogen oxidase activity
I0U46_RS04985	COG0456	acetyltransferase
I0U46_RS04995	COG2837	iron assimilation
I0U46_RS05005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I0U46_RS05010	COG4208	sulfate ABC transporter
I0U46_RS05015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I0U46_RS05020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0U46_RS05025	COG2190	(PTS) system
I0U46_RS05035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0U46_RS05040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0U46_RS05050	COG3115	cell septum assembly
I0U46_RS05055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I0U46_RS05060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0U46_RS05065	COG3530	Putative quorum-sensing-regulated virulence factor
I0U46_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS05090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I0U46_RS05150	COG1396	sequence-specific DNA binding
I0U46_RS05190	COG2067	long-chain fatty acid transport protein
I0U46_RS05195	COG3691	Protein conserved in bacteria
I0U46_RS05200	COG0183	Belongs to the thiolase family
I0U46_RS05205	COG1024	Enoyl-CoA hydratase
I0U46_RS05205	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0U46_RS05210	COG2062	phosphohistidine phosphatase, SixA
I0U46_RS05215	COG2840	Smr protein MutS2
I0U46_RS05220	COG0783	Belongs to the Dps family
I0U46_RS05230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I0U46_RS05235	COG0730	response to heat
I0U46_RS05240	COG3101	peptidyl-lysine hydroxylation
I0U46_RS05260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I0U46_RS05260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0U46_RS05265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0U46_RS05270	COG0697	spore germination
I0U46_RS05275	COG2207	Transcriptional regulator
I0U46_RS05280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0U46_RS05285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0U46_RS05295	COG0586	Pfam SNARE associated Golgi protein
I0U46_RS05300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I0U46_RS05305	COG0285	dihydrofolate synthase activity
I0U46_RS05310	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I0U46_RS05315	COG1286	toxin biosynthetic process
I0U46_RS05320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I0U46_RS05325	COG0163	prenyltransferase activity
I0U46_RS05330	COG1090	epimerase
I0U46_RS05335	COG0625	glutathione transferase activity
I0U46_RS05340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I0U46_RS05350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0U46_RS05360	COG3037	sugar-specific permease SgaT UlaA
I0U46_RS05390	COG0280	phosphate acetyltransferase
I0U46_RS05390	COG0857	belongs to the CobB CobQ family
I0U46_RS05395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I0U46_RS05400	COG3092	negative regulation of chromosome organization
I0U46_RS05405	COG3013	Belongs to the UPF0304 family
I0U46_RS05410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0U46_RS05415	COG0490	domain, Protein
I0U46_RS05415	COG0471	metal ion transport
I0U46_RS05420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I0U46_RS05425	COG0436	Aminotransferase
I0U46_RS05430	COG0583	DNA-binding transcription factor activity
I0U46_RS05435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0U46_RS05440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0U46_RS05445	COG0649	NAD binding
I0U46_RS05445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0U46_RS05455	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I0U46_RS05465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I0U46_RS05470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0U46_RS05475	COG0839	Belongs to the complex I subunit 6 family
I0U46_RS05480	COG0713	ATP synthesis coupled electron transport
I0U46_RS05485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0U46_RS05490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0U46_RS05495	COG1007	ATP synthesis coupled electron transport
I0U46_RS05510	COG1169	isochorismate synthase
I0U46_RS05515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I0U46_RS05520	COG0596	Alpha beta hydrolase
I0U46_RS05525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I0U46_RS05530	COG1441	menaquinone biosynthetic process
I0U46_RS05550	COG0814	amino acid
I0U46_RS05560	COG0633	Ferredoxin
I0U46_RS05565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0U46_RS05570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0U46_RS05575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0U46_RS05585	COG2205	protein histidine kinase activity
I0U46_RS05585	COG0784	Response regulator, receiver
I0U46_RS05590	COG2197	response regulator
I0U46_RS05595	COG0642	Histidine kinase
I0U46_RS05595	COG2198	Histidine kinase
I0U46_RS05725	COG3302	dmso reductase anchor subunit
I0U46_RS05730	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS05735	COG0243	molybdopterin cofactor binding
I0U46_RS05740	COG0668	transmembrane transport
I0U46_RS05745	COG3247	response to pH
I0U46_RS05755	COG1396	sequence-specific DNA binding
I0U46_RS05760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I0U46_RS05785	COG1902	pentaerythritol trinitrate reductase activity
I0U46_RS05800	COG1607	acyl-coa hydrolase
I0U46_RS05815	COG2814	Major facilitator Superfamily
I0U46_RS05820	COG1560	Kdo2-lipid A biosynthetic process
I0U46_RS05860	COG0418	dihydroorotase activity
I0U46_RS05900	COG1285	pathogenesis
I0U46_RS05920	COG1360	Flagellar Motor Protein
I0U46_RS05925	COG2198	Histidine kinase
I0U46_RS05925	COG0643	Histidine kinase
I0U46_RS05930	COG0835	chemotaxis
I0U46_RS05935	COG0840	transmembrane signaling receptor activity
I0U46_RS05940	COG0840	transmembrane signaling receptor activity
I0U46_RS05950	COG2201	protein-glutamate methylesterase activity
I0U46_RS05955	COG0745	RESPONSE REGULATOR receiver
I0U46_RS05970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0U46_RS05985	COG3210	domain, Protein
I0U46_RS06005	COG1815	bacterial-type flagellum-dependent cell motility
I0U46_RS06010	COG1558	bacterial-type flagellum-dependent cell motility
I0U46_RS06035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I0U46_RS06040	COG1706	bacterial-type flagellum-dependent cell motility
I0U46_RS06050	COG1256	bacterial-type flagellum assembly
I0U46_RS06065	COG1987	bacterial-type flagellum assembly
I0U46_RS06070	COG1338	Plays a role in the flagellum-specific transport system
I0U46_RS06090	COG1580	Controls the rotational direction of flagella during chemotaxis
I0U46_RS06100	COG2882	bacterial-type flagellum organization
I0U46_RS06105	COG1157	protein secretion by the type III secretion system
I0U46_RS06120	COG1766	The M ring may be actively involved in energy transduction
I0U46_RS06125	COG1677	Flagellar hook-basal body complex protein FliE
I0U46_RS06175	COG1191	sigma factor activity
I0U46_RS06185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I0U46_RS06185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I0U46_RS06185	COG0506	proline dehydrogenase activity
I0U46_RS06190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0U46_RS06200	COG1113	amino acid transport
I0U46_RS06215	COG0589	response to stress
I0U46_RS06225	COG2226	methyltransferase
I0U46_RS06230	COG1971	Probably functions as a manganese efflux pump
I0U46_RS06235	COG1760	l-serine dehydratase
I0U46_RS06240	COG0494	nUDIX hydrolase
I0U46_RS06250	COG3140	Belongs to the UPF0181 family
I0U46_RS06265	COG1115	amino acid carrier protein
I0U46_RS06270	COG3023	N-Acetylmuramoyl-L-alanine amidase
I0U46_RS06275	COG1114	Component of the transport system for branched-chain amino acids
I0U46_RS06280	COG0561	phosphatase activity
I0U46_RS06295	COG1113	amino acid transport
I0U46_RS06315	COG1830	Aldolase
I0U46_RS06320	COG1597	lipid kinase activity
I0U46_RS06325	COG0826	peptidase U32
I0U46_RS06330	COG0745	RESPONSE REGULATOR receiver
I0U46_RS06335	COG2205	protein histidine kinase activity
I0U46_RS06340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0U46_RS06345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0U46_RS06350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0U46_RS06360	COG0675	Transposase, IS605 OrfB family
I0U46_RS06385	COG2239	Acts as a magnesium transporter
I0U46_RS06395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I0U46_RS06400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0U46_RS06405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I0U46_RS06410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I0U46_RS06415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I0U46_RS06420	COG2233	PERMEase
I0U46_RS06425	COG0668	transmembrane transport
I0U46_RS06430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I0U46_RS06435	COG2211	Major facilitator Superfamily
I0U46_RS06440	COG1393	Belongs to the ArsC family
I0U46_RS06445	COG4783	chaperone-mediated protein folding
I0U46_RS06450	COG0628	permease
I0U46_RS06455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I0U46_RS06460	COG2716	regulation of RNA biosynthetic process
I0U46_RS06465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0U46_RS06470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I0U46_RS06475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I0U46_RS06480	COG2321	neutral zinc metallopeptidase
I0U46_RS06485	COG2707	UPF0756 membrane protein
I0U46_RS06490	COG1444	tRNA N-acetyltransferase activity
I0U46_RS06500	COG2832	Protein of unknown function (DUF454)
I0U46_RS06505	COG1876	peptidase activity
I0U46_RS06510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0U46_RS06515	COG1393	Belongs to the ArsC family
I0U46_RS06525	COG2197	response regulator
I0U46_RS06530	COG0281	malic enzyme
I0U46_RS06530	COG0280	phosphate acetyltransferase
I0U46_RS06545	COG1770	oligopeptidase
I0U46_RS06550	COG4206	TonB-dependent receptor
I0U46_RS06550	COG1629	transport
I0U46_RS06555	COG1570	exodeoxyribonuclease VII activity
I0U46_RS06560	COG0517	IMP dehydrogenase activity
I0U46_RS06560	COG0516	GMP reductase activity
I0U46_RS06565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I0U46_RS06565	COG0519	Catalyzes the synthesis of GMP from XMP
I0U46_RS06570	COG0582	viral genome integration into host DNA
I0U46_RS06670	COG1484	DNA-dependent DNA replication
I0U46_RS06680	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I0U46_RS06705	COG1783	phage Terminase large subunit
I0U46_RS06805	COG2246	polysaccharide biosynthetic process
I0U46_RS06830	COG3541	Predicted nucleotidyltransferase
I0U46_RS06845	COG1324	tolerance protein
I0U46_RS06855	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0U46_RS06860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I0U46_RS06865	COG3842	ATPase activity
I0U46_RS06910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0U46_RS06925	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I0U46_RS06930	COG1494	fructose-1,6-bisphosphatase
I0U46_RS06935	COG0778	Nitroreductase
I0U46_RS06940	COG2197	response regulator
I0U46_RS06945	COG0322	excinuclease ABC activity
I0U46_RS06950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I0U46_RS06980	COG3683	transport system, periplasmic component
I0U46_RS06985	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I0U46_RS07005	COG2076	Multidrug Resistance protein
I0U46_RS07015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I0U46_RS07020	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I0U46_RS07025	COG2186	Transcriptional regulator
I0U46_RS07040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0U46_RS07045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0U46_RS07050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I0U46_RS07055	COG3713	MltA-interacting MipA family protein
I0U46_RS07070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0U46_RS07075	COG3139	Protein of unknown function (DUF1315)
I0U46_RS07080	COG1335	isochorismatase
I0U46_RS07085	COG0252	asparaginase activity
I0U46_RS07090	COG0616	signal peptide processing
I0U46_RS07095	COG0778	Nitroreductase
I0U46_RS07100	COG0709	Synthesizes selenophosphate from selenide and ATP
I0U46_RS07105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0U46_RS07110	COG0708	Exodeoxyribonuclease III
I0U46_RS07115	COG0583	DNA-binding transcription factor activity
I0U46_RS07125	COG0788	formyltetrahydrofolate deformylase activity
I0U46_RS07130	COG3012	SEC-C Motif Domain Protein
I0U46_RS07135	COG0745	RESPONSE REGULATOR receiver
I0U46_RS07140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0U46_RS07155	COG1435	thymidine kinase activity
I0U46_RS07160	COG1012	belongs to the aldehyde dehydrogenase family
I0U46_RS07160	COG1454	alcohol dehydrogenase
I0U46_RS07165	COG2095	MarC family integral membrane protein
I0U46_RS07170	COG4608	Belongs to the ABC transporter superfamily
I0U46_RS07180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0U46_RS07185	COG0601	transmembrane transport
I0U46_RS07190	COG4166	transmembrane transport
I0U46_RS07195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0U46_RS07225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0U46_RS07230	COG0444	Belongs to the ABC transporter superfamily
I0U46_RS07240	COG1396	sequence-specific DNA binding
I0U46_RS07250	COG3539	Fimbrial protein
I0U46_RS07260	COG3188	usher protein
I0U46_RS07275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0U46_RS07280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0U46_RS07285	COG1309	transcriptional regulator
I0U46_RS07290	COG1012	belongs to the aldehyde dehydrogenase family
I0U46_RS07295	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I0U46_RS07300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I0U46_RS07305	COG0402	S-adenosylhomocysteine deaminase activity
I0U46_RS07310	COG0675	Transposase, IS605 OrfB family
I0U46_RS07325	COG0113	porphobilinogen synthase activity
I0U46_RS07345	COG0589	response to stress
I0U46_RS07355	COG0589	response to stress
I0U46_RS07380	COG2966	Psort location CytoplasmicMembrane, score
I0U46_RS07385	COG3610	response to peptide
I0U46_RS07395	COG2356	endonuclease I
I0U46_RS07405	COG1702	phosphate starvation-inducible protein PhoH
I0U46_RS07410	COG3152	Membrane
I0U46_RS07425	COG1294	oxidase, subunit
I0U46_RS07430	COG1271	oxidase subunit
I0U46_RS07435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0U46_RS07440	COG1280	lysine exporter protein (LysE YggA)
I0U46_RS07450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I0U46_RS07455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0U46_RS07460	COG4558	Periplasmic binding protein
I0U46_RS07465	COG3720	iron ion transport
I0U46_RS07470	COG4771	TonB-dependent receptor
I0U46_RS07485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I0U46_RS07490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I0U46_RS07495	COG0574	Belongs to the PEP-utilizing enzyme family
I0U46_RS07495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I0U46_RS07500	COG0628	permease
I0U46_RS07505	COG0277	FAD linked oxidase domain protein
I0U46_RS07505	COG0247	lactate metabolic process
I0U46_RS07510	COG2050	protein possibly involved in aromatic compounds catabolism
I0U46_RS07520	COG0316	Belongs to the HesB IscA family
I0U46_RS07525	COG0719	Fe-S assembly protein
I0U46_RS07530	COG0396	ATPase activity
I0U46_RS07535	COG0719	Fe-S assembly protein
I0U46_RS07540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I0U46_RS07545	COG2166	iron-sulfur cluster assembly
I0U46_RS07550	COG1388	LysM domain
I0U46_RS07550	COG1376	ErfK ybiS ycfS ynhG family protein
I0U46_RS07565	COG0076	glutamate decarboxylase activity
I0U46_RS07570	COG0531	amino acid
I0U46_RS07590	COG0534	Mate efflux family protein
I0U46_RS07595	COG0307	riboflavin synthase, alpha
I0U46_RS07600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0U46_RS07605	COG2814	Major facilitator Superfamily
I0U46_RS07610	COG0583	DNA-binding transcription factor activity
I0U46_RS07615	COG1609	Transcriptional regulator
I0U46_RS07630	COG0730	response to heat
I0U46_RS07645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0U46_RS07650	COG0582	viral genome integration into host DNA
I0U46_RS07695	COG0629	single-stranded DNA binding
I0U46_RS07700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I0U46_RS07705	COG5532	Uncharacterized conserved protein (DUF2303)
I0U46_RS07760	COG1403	HNH endonuclease
I0U46_RS07795	COG3772	lysozyme
I0U46_RS07820	COG1802	Transcriptional regulator
I0U46_RS07820	COG4626	Terminase
I0U46_RS07825	COG4695	Portal protein
I0U46_RS07830	COG0740	serine-type endopeptidase activity
I0U46_RS07950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I0U46_RS07960	COG0675	Transposase, IS605 OrfB family
I0U46_RS07965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0U46_RS07970	COG0346	lactoylglutathione lyase activity
I0U46_RS07975	COG3313	Fe-S protein
I0U46_RS07990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I0U46_RS07995	COG0259	pyridoxamine-phosphate oxidase activity
I0U46_RS08000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I0U46_RS08015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I0U46_RS08025	COG4172	Belongs to the ABC transporter superfamily
I0U46_RS08030	COG4171	peptide transport system, permease
I0U46_RS08040	COG4166	transmembrane transport
I0U46_RS08045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I0U46_RS08050	COG1842	Phage shock protein A
I0U46_RS08060	COG1983	PspC domain protein
I0U46_RS08070	COG3106	COG3106 Predicted ATPase
I0U46_RS08075	COG3768	UPF0283 membrane protein
I0U46_RS08090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I0U46_RS08095	COG4166	transmembrane transport
I0U46_RS08110	COG0598	Magnesium transport protein CorA
I0U46_RS08130	COG0346	lactoylglutathione lyase activity
I0U46_RS08145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0U46_RS08165	COG2917	probably involved in intracellular septation
I0U46_RS08180	COG3047	cAMP biosynthetic process
I0U46_RS08190	COG0159	tryptophan synthase activity
I0U46_RS08195	COG0133	tryptophan synthase activity
I0U46_RS08205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0U46_RS08210	COG0512	Glutamine amidotransferase of anthranilate synthase
I0U46_RS08215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I0U46_RS08225	COG0009	L-threonylcarbamoyladenylate synthase
I0U46_RS08230	COG1187	pseudouridine synthase activity
I0U46_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS08250	COG0616	signal peptide processing
I0U46_RS08260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0U46_RS08275	COG3501	Rhs element vgr protein
I0U46_RS08295	COG0583	DNA-binding transcription factor activity
I0U46_RS08305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I0U46_RS08315	COG1464	Belongs to the NlpA lipoprotein family
I0U46_RS08320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I0U46_RS08325	COG0671	phosphoesterase, PA-phosphatase related
I0U46_RS08330	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I0U46_RS08335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I0U46_RS08340	COG0284	orotidine-5'-phosphate decarboxylase activity
I0U46_RS08345	COG0023	Translation Initiation Factor
I0U46_RS08350	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I0U46_RS08355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I0U46_RS08365	COG4659	FMN binding
I0U46_RS08375	COG4656	Part of a membrane complex involved in electron transport
I0U46_RS08385	COG4657	Part of a membrane complex involved in electron transport
I0U46_RS08395	COG0673	inositol 2-dehydrogenase activity
I0U46_RS08400	COG0385	Bile acid
I0U46_RS08405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I0U46_RS08415	COG5339	Protein conserved in bacteria
I0U46_RS08420	COG0114	fumarate hydratase activity
I0U46_RS08430	COG2814	Major facilitator Superfamily
I0U46_RS08435	COG0583	DNA-binding transcription factor activity
I0U46_RS08440	COG1940	carbohydrate kinase activity
I0U46_RS08445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I0U46_RS08460	COG4221	oxidoreductase activity
I0U46_RS08520	COG4628	conserved protein (DUF2132)
I0U46_RS08525	COG1609	Transcriptional regulator
I0U46_RS08525	COG2207	Transcriptional regulator
I0U46_RS08530	COG0436	Aminotransferase
I0U46_RS08535	COG1757	Na H antiporter
I0U46_RS08540	COG2115	Belongs to the xylose isomerase family
I0U46_RS08545	COG1070	Carbohydrate kinase
I0U46_RS08565	COG0443	Heat shock 70 kDa protein
I0U46_RS08575	COG1538	Outer membrane efflux protein
I0U46_RS08580	COG1289	transmembrane transporter activity
I0U46_RS08595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I0U46_RS08600	COG0477	Major facilitator Superfamily
I0U46_RS08610	COG2814	Major facilitator Superfamily
I0U46_RS08620	COG0402	S-adenosylhomocysteine deaminase activity
I0U46_RS08625	COG1671	Belongs to the UPF0178 family
I0U46_RS08630	COG0488	(ABC) transporter
I0U46_RS08640	COG1309	transcriptional regulator
I0U46_RS08650	COG0583	DNA-binding transcription factor activity
I0U46_RS08660	COG2814	Major facilitator Superfamily
I0U46_RS08680	COG1464	Belongs to the NlpA lipoprotein family
I0U46_RS08700	COG1181	Belongs to the D-alanine--D-alanine ligase family
I0U46_RS08705	COG0488	(ABC) transporter
I0U46_RS08710	COG3097	Belongs to the UPF0267 family
I0U46_RS08715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0U46_RS08715	COG2169	Transcriptional regulator
I0U46_RS08720	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0U46_RS08740	COG0251	oxidation-reduction process
I0U46_RS08750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0U46_RS08760	COG2376	Dihydroxyacetone kinase
I0U46_RS08780	COG1349	DNA-binding transcription factor activity
I0U46_RS08785	COG0243	molybdopterin cofactor binding
I0U46_RS08790	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS08795	COG3302	dmso reductase anchor subunit
I0U46_RS08800	COG3381	protein complex oligomerization
I0U46_RS08805	COG0590	tRNA wobble adenosine to inosine editing
I0U46_RS08810	COG0666	response to abiotic stimulus
I0U46_RS08815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I0U46_RS08820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I0U46_RS08825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I0U46_RS08830	COG2205	protein histidine kinase activity
I0U46_RS08835	COG0745	RESPONSE REGULATOR receiver
I0U46_RS08840	COG0842	Transport permease protein
I0U46_RS08845	COG1129	ABC transporter
I0U46_RS08845	COG0842	Transport permease protein
I0U46_RS08850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0U46_RS08860	COG4974	Belongs to the 'phage' integrase family
I0U46_RS08865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0U46_RS08895	COG3634	alkyl hydroperoxide reductase activity
I0U46_RS08915	COG1695	Transcriptional regulator
I0U46_RS08925	COG3321	synthase
I0U46_RS08925	COG0604	alcohol dehydrogenase
I0U46_RS08925	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS08940	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS08945	COG0243	molybdopterin cofactor binding
I0U46_RS08950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0U46_RS08955	COG0589	response to stress
I0U46_RS08960	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I0U46_RS08965	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I0U46_RS08975	COG0531	amino acid
I0U46_RS08985	COG3121	Chaperone
I0U46_RS08990	COG3188	usher protein
I0U46_RS09000	COG1643	Atp-dependent helicase
I0U46_RS09020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I0U46_RS09030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I0U46_RS09055	COG3784	Protein of unknown function (DUF1318)
I0U46_RS09065	COG2911	Protein conserved in bacteria
I0U46_RS09070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0U46_RS09085	COG3708	Transcriptional regulator
I0U46_RS09085	COG2207	Transcriptional regulator
I0U46_RS09095	COG4619	ABC transporter
I0U46_RS09100	COG0390	transport system, permease component
I0U46_RS09105	COG2983	Belongs to the UPF0260 family
I0U46_RS09110	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0U46_RS09115	COG2951	lytic endotransglycosylase activity
I0U46_RS09120	COG3100	YcgL domain-containing protein
I0U46_RS09125	COG0850	regulation of cytokinetic process
I0U46_RS09130	COG2894	cell division
I0U46_RS09135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I0U46_RS09140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I0U46_RS09145	COG0318	PFAM AMP-dependent synthetase and ligase
I0U46_RS09150	COG3065	identical protein binding
I0U46_RS09160	COG1199	ATP-dependent helicase activity
I0U46_RS09165	COG0251	oxidation-reduction process
I0U46_RS09170	COG0702	epimerase
I0U46_RS09175	COG2076	Multidrug Resistance protein
I0U46_RS09180	COG2076	Multidrug Resistance protein
I0U46_RS09185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0U46_RS09190	COG1737	Transcriptional regulator
I0U46_RS09195	COG0469	pyruvate kinase activity
I0U46_RS09200	COG1560	Kdo2-lipid A biosynthetic process
I0U46_RS09205	COG0739	heme binding
I0U46_RS09210	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I0U46_RS09215	COG1121	(ABC) transporter
I0U46_RS09220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0U46_RS09225	COG2255	four-way junction helicase activity
I0U46_RS09230	COG0632	four-way junction helicase activity
I0U46_RS09235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I0U46_RS09240	COG0217	transcriptional regulatory protein
I0U46_RS09245	COG0494	nUDIX hydrolase
I0U46_RS09250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I0U46_RS09255	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I0U46_RS09260	COG2226	methyltransferase
I0U46_RS09265	COG0500	methyltransferase
I0U46_RS09270	COG0488	(ABC) transporter
I0U46_RS09280	COG3142	Participates in the control of copper homeostasis
I0U46_RS09285	COG3102	Protein conserved in bacteria
I0U46_RS09290	COG0018	arginyl-trna synthetase
I0U46_RS09300	COG0728	peptidoglycan biosynthetic process
I0U46_RS09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0U46_RS09310	COG0477	Major facilitator Superfamily
I0U46_RS09320	COG3381	protein complex oligomerization
I0U46_RS09335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0U46_RS09345	COG0659	secondary active sulfate transmembrane transporter activity
I0U46_RS09360	COG1242	4 iron, 4 sulfur cluster binding
I0U46_RS09365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I0U46_RS09370	COG2912	Transglutaminase-like superfamily
I0U46_RS09380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I0U46_RS09385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I0U46_RS09390	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I0U46_RS09395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I0U46_RS09400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I0U46_RS09410	COG0193	aminoacyl-tRNA hydrolase activity
I0U46_RS09415	COG0012	GTP binding
I0U46_RS09485	COG0586	Pfam SNARE associated Golgi protein
I0U46_RS09500	COG2186	Transcriptional regulator
I0U46_RS09505	COG0579	oxidoreductase
I0U46_RS09510	COG2207	Transcriptional regulator
I0U46_RS09515	COG0095	Lipoate-protein ligase
I0U46_RS09520	COG0791	NLP P60 protein
I0U46_RS09525	COG2076	Multidrug Resistance protein
I0U46_RS09530	COG2076	Multidrug Resistance protein
I0U46_RS09535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I0U46_RS09540	COG0726	polysaccharide deacetylase
I0U46_RS09545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0U46_RS09545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0U46_RS09550	COG0463	Glycosyl transferase, family 2
I0U46_RS09555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0U46_RS09560	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I0U46_RS09565	COG4139	cobalamin transport
I0U46_RS09570	COG0776	regulation of translation
I0U46_RS09575	COG0072	phenylalanine-tRNA ligase activity
I0U46_RS09575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0U46_RS09580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I0U46_RS09590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I0U46_RS09595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I0U46_RS09600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I0U46_RS09605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0U46_RS09610	COG3539	Fimbrial protein
I0U46_RS09620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0U46_RS09640	COG0803	Belongs to the bacterial solute-binding protein 9 family
I0U46_RS09645	COG1121	(ABC) transporter
I0U46_RS09650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0U46_RS09655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0U46_RS09660	COG3001	Fructosamine kinase
I0U46_RS09670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0U46_RS09675	COG1988	membrane-bound metal-dependent
I0U46_RS09680	COG1823	symporter activity
I0U46_RS09690	COG0501	Belongs to the peptidase M48B family
I0U46_RS09705	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I0U46_RS09710	COG1956	GAF domain-containing protein
I0U46_RS09715	COG2995	paraquat-inducible protein a
I0U46_RS09720	COG3008	intermembrane lipid transfer
I0U46_RS09735	COG1276	copper resistance
I0U46_RS09740	COG2372	response to copper ion
I0U46_RS09745	COG1528	Iron-storage protein
I0U46_RS09765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I0U46_RS09770	COG1598	PFAM Uncharacterised protein family UPF0150
I0U46_RS09775	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I0U46_RS09785	COG0024	Methionine aminopeptidase
I0U46_RS09815	COG2841	Protein conserved in bacteria
I0U46_RS09825	COG3272	Protein of unknown function (DUF1722)
I0U46_RS09840	COG0500	methyltransferase
I0U46_RS09845	COG3969	phosphoadenosine phosphosulfate
I0U46_RS09850	COG1475	DNA binding
I0U46_RS09860	COG0572	uridine kinase
I0U46_RS09870	COG0702	epimerase
I0U46_RS09875	COG1733	regulation of RNA biosynthetic process
I0U46_RS09885	COG0071	Belongs to the small heat shock protein (HSP20) family
I0U46_RS09890	COG1278	Cold shock
I0U46_RS09925	COG0538	isocitrate dehydrogenase activity
I0U46_RS09930	COG1187	pseudouridine synthase activity
I0U46_RS09940	COG0482	sulfurtransferase activity
I0U46_RS09945	COG2915	High frequency lysogenization protein hflD homolog
I0U46_RS09950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I0U46_RS09955	COG0745	RESPONSE REGULATOR receiver
I0U46_RS09960	COG2205	protein histidine kinase activity
I0U46_RS09965	COG2850	peptidyl-arginine hydroxylation
I0U46_RS09980	COG4591	ABC-type transport system involved in lipoprotein release permease component
I0U46_RS09990	COG4591	ABC-type transport system involved in lipoprotein release permease component
I0U46_RS09995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I0U46_RS10000	COG3134	Outer membrane lipoprotein
I0U46_RS10005	COG1252	NADH dehydrogenase
I0U46_RS10015	COG1472	Belongs to the glycosyl hydrolase 3 family
I0U46_RS10025	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I0U46_RS10030	COG5633	Lipoprotein
I0U46_RS10035	COG0537	adenosine 5'-monophosphoramidase activity
I0U46_RS10040	COG0084	hydrolase, TatD family'
I0U46_RS10045	COG0470	DNA polymerase III
I0U46_RS10050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I0U46_RS10055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I0U46_RS10060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0U46_RS10065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0U46_RS10070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0U46_RS10085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0U46_RS10090	COG0416	fatty acid biosynthetic process
I0U46_RS10095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I0U46_RS10100	COG1399	metal-binding, possibly nucleic acid-binding protein
I0U46_RS10105	COG0424	maF-like protein
I0U46_RS10115	COG0564	pseudouridine synthase activity
I0U46_RS10120	COG1530	ribonuclease E activity
I0U46_RS10125	COG2926	Belongs to the UPF0265 family
I0U46_RS10130	COG2211	Major facilitator Superfamily
I0U46_RS10135	COG2925	Exonuclease
I0U46_RS10140	COG0277	FAD linked oxidase domain protein
I0U46_RS10145	COG0583	DNA-binding transcription factor activity
I0U46_RS10150	COG3961	Belongs to the TPP enzyme family
I0U46_RS10160	COG0531	amino acid
I0U46_RS10165	COG4771	TonB-dependent receptor
I0U46_RS10170	COG0833	amino acid
I0U46_RS10175	COG0583	DNA-binding transcription factor activity
I0U46_RS10180	COG2855	membrane
I0U46_RS10185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I0U46_RS10190	COG0494	nUDIX hydrolase
I0U46_RS10200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I0U46_RS10215	COG0671	phosphoesterase, PA-phosphatase related
I0U46_RS10220	COG0791	NLP P60 protein
I0U46_RS10230	COG2814	Major facilitator Superfamily
I0U46_RS10235	COG1187	pseudouridine synthase activity
I0U46_RS10240	COG1061	Type III restriction enzyme res subunit
I0U46_RS10245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I0U46_RS10250	COG3081	Nucleoid-associated protein
I0U46_RS10255	COG3082	Protein of unknown function (DUF1414)
I0U46_RS10260	COG3083	sulfuric ester hydrolase activity
I0U46_RS10270	COG1280	lysine exporter protein (LysE YggA)
I0U46_RS10280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I0U46_RS10305	COG1560	Kdo2-lipid A biosynthetic process
I0U46_RS10310	COG1278	Cold shock
I0U46_RS10325	COG2207	Transcriptional regulator
I0U46_RS10325	COG3708	Transcriptional regulator
I0U46_RS10335	COG0656	L-ascorbic acid biosynthetic process
I0U46_RS10340	COG0583	DNA-binding transcription factor activity
I0U46_RS10355	COG3615	Tellurite resistance protein tehB
I0U46_RS10365	COG0456	acetyltransferase
I0U46_RS10375	COG2920	part of a sulfur-relay system
I0U46_RS10380	COG1254	Belongs to the acylphosphatase family
I0U46_RS10385	COG3785	DNA binding
I0U46_RS10390	COG1832	CoA-binding protein
I0U46_RS10395	COG1803	Methylglyoxal synthase
I0U46_RS10400	COG0210	DNA helicase
I0U46_RS10405	COG1289	transmembrane transporter activity
I0U46_RS10410	COG3070	regulator of competence-specific genes
I0U46_RS10420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I0U46_RS10420	COG2885	chlorophyll binding
I0U46_RS10425	COG3120	sequence-specific DNA binding
I0U46_RS10430	COG1067	ATP-dependent peptidase activity
I0U46_RS10435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0U46_RS10440	COG3130	regulation of translation
I0U46_RS10450	COG3009	Protein conserved in bacteria
I0U46_RS10455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I0U46_RS10455	COG3008	intermembrane lipid transfer
I0U46_RS10460	COG2995	paraquat-inducible protein a
I0U46_RS10465	COG0488	(ABC) transporter
I0U46_RS10470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I0U46_RS10470	COG0116	Belongs to the methyltransferase superfamily
I0U46_RS10475	COG0633	Ferredoxin
I0U46_RS10475	COG3217	Mosc domain protein beta barrel domain protein
I0U46_RS10485	COG0167	dihydroorotate dehydrogenase activity
I0U46_RS10495	COG0308	aminopeptidase N
I0U46_RS10500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I0U46_RS10510	COG0017	Asparaginyl-tRNA synthetase
I0U46_RS10515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I0U46_RS10520	COG1448	Aminotransferase
I0U46_RS10615	COG0675	Transposase, IS605 OrfB family
I0U46_RS10660	COG3501	Rhs element vgr protein
I0U46_RS10750	COG3157	Type VI secretion system effector, Hcp
I0U46_RS10755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0U46_RS10760	COG3108	Peptidase M15
I0U46_RS10765	COG2989	Protein conserved in bacteria
I0U46_RS10770	COG3700	Belongs to the class B bacterial acid phosphatase family
I0U46_RS10780	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I0U46_RS10785	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I0U46_RS10790	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I0U46_RS10795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0U46_RS10800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I0U46_RS10805	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I0U46_RS10810	COG2835	tetraacyldisaccharide 4'-kinase activity
I0U46_RS10820	COG1663	tetraacyldisaccharide 4'-kinase activity
I0U46_RS10825	COG1132	(ABC) transporter
I0U46_RS10830	COG2333	competence protein COMEC
I0U46_RS10830	COG0658	competence protein
I0U46_RS10835	COG0776	regulation of translation
I0U46_RS10840	COG0539	negative regulation of cytoplasmic translation
I0U46_RS10845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I0U46_RS10850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I0U46_RS10855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I0U46_RS10865	COG3210	domain, Protein
I0U46_RS10870	COG0252	asparaginase activity
I0U46_RS10875	COG1944	ATP diphosphatase activity
I0U46_RS10880	COG2116	formate transmembrane transporter activity
I0U46_RS10885	COG1882	Formate acetyltransferase
I0U46_RS10890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I0U46_RS10900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I0U46_RS10910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I0U46_RS10915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I0U46_RS10920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I0U46_RS10925	COG3107	peptidoglycan biosynthetic process
I0U46_RS10925	COG1674	ftsk spoiiie
I0U46_RS10935	COG0492	ferredoxin-NADP+ reductase activity
I0U46_RS10945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I0U46_RS10950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I0U46_RS10955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I0U46_RS10960	COG0542	response to heat
I0U46_RS10965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I0U46_RS10970	COG1278	Cold shock
I0U46_RS10975	COG0577	efflux transmembrane transporter activity
I0U46_RS10975	COG1136	(ABC) transporter
I0U46_RS10980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0U46_RS10985	COG3593	DNA synthesis involved in DNA repair
I0U46_RS10990	COG2431	L-lysine efflux transmembrane transporter activity
I0U46_RS10995	COG0702	epimerase
I0U46_RS11000	COG1126	abc transporter atp-binding protein
I0U46_RS11005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0U46_RS11010	COG4215	(ABC) transporter
I0U46_RS11015	COG4160	amino acid transport
I0U46_RS11020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I0U46_RS11035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I0U46_RS11040	COG0432	Pfam Uncharacterised protein family UPF0047
I0U46_RS11045	COG0671	phosphoesterase, PA-phosphatase related
I0U46_RS11050	COG0814	amino acid
I0U46_RS11055	COG1760	l-serine dehydratase
I0U46_RS11060	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I0U46_RS11065	COG1686	Belongs to the peptidase S11 family
I0U46_RS11070	COG0625	glutathione transferase activity
I0U46_RS11075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0U46_RS11080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I0U46_RS11085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I0U46_RS11095	COG0131	Imidazoleglycerol-phosphate dehydratase
I0U46_RS11095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I0U46_RS11100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I0U46_RS11105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I0U46_RS11110	COG0107	imidazoleglycerol-phosphate synthase activity
I0U46_RS11115	COG0140	phosphoribosyl-ATP diphosphatase activity
I0U46_RS11115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I0U46_RS11120	COG1454	alcohol dehydrogenase
I0U46_RS11125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I0U46_RS11130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I0U46_RS11135	COG1253	flavin adenine dinucleotide binding
I0U46_RS11140	COG3069	C4-dicarboxylate transmembrane transporter activity
I0U46_RS11145	COG2982	Protein involved in outer membrane biogenesis
I0U46_RS11150	COG0717	Belongs to the dCTP deaminase family
I0U46_RS11155	COG0572	uridine kinase
I0U46_RS11160	COG0489	protein tyrosine kinase activity
I0U46_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0U46_RS11165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0U46_RS11170	COG1380	Effector of murein hydrolase LrgA
I0U46_RS11175	COG1346	cytolysis
I0U46_RS11180	COG0295	cytidine deaminase activity
I0U46_RS11185	COG0281	malic enzyme
I0U46_RS11190	COG2949	membrane
I0U46_RS11195	COG2311	Membrane
I0U46_RS11200	COG0302	gtp cyclohydrolase
I0U46_RS11205	COG0477	Major facilitator Superfamily
I0U46_RS11215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0U46_RS11250	COG0583	DNA-binding transcription factor activity
I0U46_RS11255	COG2079	MmgE PrpD family protein
I0U46_RS11270	COG3069	C4-dicarboxylate transmembrane transporter activity
I0U46_RS11280	COG2897	thiosulfate sulfurtransferase activity
I0U46_RS11295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0U46_RS11300	COG0513	Belongs to the DEAD box helicase family
I0U46_RS11305	COG1309	transcriptional regulator
I0U46_RS11315	COG1131	(ABC) transporter
I0U46_RS11320	COG0842	Transport permease protein
I0U46_RS11325	COG0842	Transport permease protein
I0U46_RS11330	COG0670	Belongs to the BI1 family
I0U46_RS11335	COG0314	molybdopterin synthase activity
I0U46_RS11340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I0U46_RS11345	COG0315	cyclic pyranopterin monophosphate synthase activity
I0U46_RS11350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0U46_RS11355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I0U46_RS11365	COG0556	nucleotide-excision repair
I0U46_RS11375	COG2226	methyltransferase
I0U46_RS11380	COG0156	8-amino-7-oxononanoate synthase activity
I0U46_RS11385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I0U46_RS11395	COG2706	6-phosphogluconolactonase activity
I0U46_RS11400	COG0561	phosphatase activity
I0U46_RS11405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I0U46_RS11410	COG4149	molybdate abc transporter
I0U46_RS11415	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0U46_RS11425	COG3585	molybdate ion transport
I0U46_RS11425	COG2005	Transcriptional regulator
I0U46_RS11450	COG2831	hemolysin activation secretion protein
I0U46_RS11455	COG1119	ATPase activity
I0U46_RS11460	COG0588	phosphoglycerate mutase activity
I0U46_RS11465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I0U46_RS11490	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I0U46_RS11495	COG2885	chlorophyll binding
I0U46_RS11500	COG0823	Involved in the tonB-independent uptake of proteins
I0U46_RS11505	COG3064	Membrane
I0U46_RS11510	COG0848	biopolymer transport protein
I0U46_RS11515	COG0811	peptide transport
I0U46_RS11520	COG0824	Thioesterase
I0U46_RS11530	COG0477	Major facilitator Superfamily
I0U46_RS11535	COG0583	DNA-binding transcription factor activity
I0U46_RS11540	COG3790	cyd operon protein YbgE
I0U46_RS11545	COG4890	Cyd operon protein YbgT
I0U46_RS11550	COG1294	oxidase, subunit
I0U46_RS11555	COG1271	oxidase subunit
I0U46_RS11560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0U46_RS11565	COG0045	succinate-CoA ligase (ADP-forming) activity
I0U46_RS11570	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0U46_RS11575	COG0567	Dehydrogenase, E1 component
I0U46_RS11585	COG1053	succinate dehydrogenase
I0U46_RS11590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I0U46_RS11610	COG2814	Major facilitator Superfamily
I0U46_RS11620	COG0714	Associated with various cellular activities
I0U46_RS11625	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I0U46_RS11630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I0U46_RS11640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0U46_RS11655	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I0U46_RS11660	COG4807	Protein conserved in bacteria
I0U46_RS11665	COG0033	Phosphoglucomutase
I0U46_RS11670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I0U46_RS11675	COG0596	Alpha beta hydrolase
I0U46_RS11685	COG0716	FMN binding
I0U46_RS11690	COG0735	belongs to the Fur family
I0U46_RS11705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I0U46_RS11715	COG0363	glucosamine-6-phosphate deaminase activity
I0U46_RS11720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I0U46_RS11725	COG1846	Transcriptional regulator
I0U46_RS11725	COG1940	carbohydrate kinase activity
I0U46_RS11775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I0U46_RS11780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0U46_RS11785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0U46_RS11790	COG1702	phosphate starvation-inducible protein PhoH
I0U46_RS11795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I0U46_RS11805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I0U46_RS11815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0U46_RS11840	COG0765	amino acid transport
I0U46_RS11845	COG0765	amino acid transport
I0U46_RS11850	COG1126	abc transporter atp-binding protein
I0U46_RS11855	COG0495	leucyl-tRNA aminoacylation
I0U46_RS11860	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I0U46_RS11865	COG1466	dna polymerase III delta subunit
I0U46_RS11870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I0U46_RS11880	COG0799	negative regulation of ribosome biogenesis
I0U46_RS11885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I0U46_RS11890	COG0768	penicillin binding
I0U46_RS11895	COG0772	Belongs to the SEDS family
I0U46_RS11900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I0U46_RS11905	COG1686	Belongs to the peptidase S11 family
I0U46_RS11915	COG0321	lipoyl(octanoyl) transferase activity
I0U46_RS11920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I0U46_RS11925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I0U46_RS11935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0U46_RS11945	COG1780	Probably involved in ribonucleotide reductase function
I0U46_RS11960	COG4175	Glycine betaine
I0U46_RS11965	COG4176	ABC-type proline glycine betaine transport system permease component
I0U46_RS11970	COG2113	Glycine betaine
I0U46_RS11975	COG1629	transport
I0U46_RS11980	COG2814	Major facilitator Superfamily
I0U46_RS11985	COG1846	Transcriptional regulator
I0U46_RS11990	COG1335	isochorismatase
I0U46_RS11995	COG2814	Major facilitator Superfamily
I0U46_RS12005	COG1566	PFAM secretion protein HlyD family protein
I0U46_RS12010	COG2814	Major facilitator Superfamily
I0U46_RS12015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0U46_RS12020	COG5160	protein modification by small protein removal
I0U46_RS12025	COG3148	PFAM DTW domain containing protein
I0U46_RS12030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0U46_RS12030	COG0045	succinate-CoA ligase (ADP-forming) activity
I0U46_RS12030	COG1042	CoA-binding domain protein
I0U46_RS12035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0U46_RS12040	COG5544	Lipoprotein
I0U46_RS12070	COG0542	response to heat
I0U46_RS12075	COG1496	oxidoreductase activity
I0U46_RS12080	COG0564	pseudouridine synthase activity
I0U46_RS12085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I0U46_RS12090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I0U46_RS12095	COG0077	Prephenate dehydratase
I0U46_RS12095	COG1605	Chorismate mutase
I0U46_RS12100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I0U46_RS12115	COG0287	Prephenate dehydrogenase
I0U46_RS12115	COG1605	Chorismate mutase
I0U46_RS12120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I0U46_RS12125	COG0335	large ribosomal subunit rRNA binding
I0U46_RS12130	COG0336	Belongs to the RNA methyltransferase TrmD family
I0U46_RS12140	COG0228	four-way junction DNA binding
I0U46_RS12145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I0U46_RS12150	COG4137	Cytochrome C assembly protein
I0U46_RS12155	COG4536	flavin adenine dinucleotide binding
I0U46_RS12160	COG1854	S-ribosylhomocysteine lyase activity
I0U46_RS12165	COG2918	glutathione biosynthetic process
I0U46_RS12195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I0U46_RS12200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0U46_RS12205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I0U46_RS12210	COG1546	Belongs to the CinA family
I0U46_RS12215	COG2814	Major facilitator Superfamily
I0U46_RS12220	COG0204	Acyl-transferase
I0U46_RS12220	COG0318	PFAM AMP-dependent synthetase and ligase
I0U46_RS12225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I0U46_RS12230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I0U46_RS12235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I0U46_RS12245	COG1073	alpha beta
I0U46_RS12250	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I0U46_RS12255	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0U46_RS12260	COG4774	siderophore transport
I0U46_RS12265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0U46_RS12275	COG3237	CsbD-like
I0U46_RS12280	COG2991	Protein conserved in bacteria
I0U46_RS12285	COG1477	protein flavinylation
I0U46_RS12290	COG2871	sodium ion transport
I0U46_RS12295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I0U46_RS12300	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I0U46_RS12305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I0U46_RS12310	COG1805	sodium ion transport
I0U46_RS12315	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I0U46_RS12320	COG3034	peptidoglycan biosynthetic process
I0U46_RS12325	COG0121	glutamine amidotransferase
I0U46_RS12330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I0U46_RS12335	COG1960	acyl-CoA dehydrogenase activity
I0U46_RS12345	COG0583	DNA-binding transcription factor activity
I0U46_RS12350	COG0583	DNA-binding transcription factor activity
I0U46_RS12370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I0U46_RS12375	COG0189	ligase activity
I0U46_RS12380	COG1678	Uncharacterized ACR, COG1678
I0U46_RS12385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I0U46_RS12390	COG2805	Type II/IV secretion system protein
I0U46_RS12395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I0U46_RS12400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0U46_RS12405	COG0762	integral membrane protein
I0U46_RS12410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I0U46_RS12415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0U46_RS12420	COG4607	ABC-type enterochelin transport system periplasmic component
I0U46_RS12430	COG2066	Belongs to the glutaminase family
I0U46_RS12435	COG3171	Protein conserved in bacteria
I0U46_RS12445	COG1194	a g-specific adenine glycosylase
I0U46_RS12450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I0U46_RS12455	COG0741	lytic transglycosylase activity
I0U46_RS12465	COG2801	Transposase and inactivated derivatives
I0U46_RS12495	COG1982	Orn Lys Arg decarboxylase major
I0U46_RS12500	COG0531	amino acid
I0U46_RS12505	COG1309	transcriptional regulator
I0U46_RS12545	COG2274	protein secretion by the type I secretion system
I0U46_RS12575	COG3708	Transcriptional regulator
I0U46_RS12575	COG2207	Transcriptional regulator
I0U46_RS12640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS12640	COG1263	PTS System
I0U46_RS12645	COG1554	hydrolase, family 65, central catalytic
I0U46_RS12650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0U46_RS12705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I0U46_RS12710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0U46_RS12720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I0U46_RS12735	COG3539	Fimbrial protein
I0U46_RS12755	COG3188	usher protein
I0U46_RS12765	COG3539	Fimbrial protein
I0U46_RS12770	COG0582	viral genome integration into host DNA
I0U46_RS12810	COG3539	Fimbrial protein
I0U46_RS12815	COG3539	Fimbrial protein
I0U46_RS12820	COG3121	Chaperone
I0U46_RS12825	COG3188	usher protein
I0U46_RS12830	COG3539	Fimbrial protein
I0U46_RS12835	COG1234	tRNA 3'-trailer cleavage
I0U46_RS12850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0U46_RS12855	COG1846	Transcriptional regulator
I0U46_RS12870	COG3104	oligopeptide transport
I0U46_RS12875	COG2314	TM2 domain
I0U46_RS12885	COG0126	phosphoglycerate kinase activity
I0U46_RS12890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0U46_RS12895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I0U46_RS12910	COG2814	Major facilitator Superfamily
I0U46_RS12915	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I0U46_RS12920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0U46_RS12925	COG0019	diaminopimelate decarboxylase activity
I0U46_RS12935	COG4264	IucA IucC family
I0U46_RS12945	COG1120	ATPase activity
I0U46_RS12950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0U46_RS12985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0U46_RS12990	COG0328	RNA-DNA hybrid ribonuclease activity
I0U46_RS12995	COG2226	methyltransferase
I0U46_RS13000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0U46_RS13005	COG1388	LysM domain
I0U46_RS13005	COG0741	lytic transglycosylase activity
I0U46_RS13010	COG3961	Belongs to the TPP enzyme family
I0U46_RS13015	COG0471	metal ion transport
I0U46_RS13020	COG0148	phosphopyruvate hydratase activity
I0U46_RS13025	COG0504	CTP synthase activity
I0U46_RS13030	COG3956	TIGRFAM MazG family protein
I0U46_RS13035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0U46_RS13040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I0U46_RS13050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0U46_RS13070	COG0316	Belongs to the HesB IscA family
I0U46_RS13075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I0U46_RS13080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0U46_RS13085	COG1643	Atp-dependent helicase
I0U46_RS13090	COG1489	DNA binding
I0U46_RS13110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I0U46_RS13115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I0U46_RS13120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I0U46_RS13125	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I0U46_RS13135	COG3851	Histidine kinase
I0U46_RS13140	COG2271	Major facilitator Superfamily
I0U46_RS13145	COG1840	ABC-type Fe3 transport system, periplasmic component
I0U46_RS13155	COG3842	ATPase activity
I0U46_RS13160	COG3048	D-serine ammonia-lyase activity
I0U46_RS13165	COG2610	gluconate transmembrane transporter activity
I0U46_RS13170	COG0583	DNA-binding transcription factor activity
I0U46_RS13175	COG0754	glutathionylspermidine amidase activity
I0U46_RS13190	COG3157	Type VI secretion system effector, Hcp
I0U46_RS13195	COG2963	transposase activity
I0U46_RS13205	COG4633	Protein conserved in bacteria
I0U46_RS13220	COG2837	iron assimilation
I0U46_RS13230	COG0243	molybdopterin cofactor binding
I0U46_RS13235	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS13250	COG0501	Belongs to the peptidase M48B family
I0U46_RS13260	COG0477	Major facilitator Superfamily
I0U46_RS13265	COG0842	Transport permease protein
I0U46_RS13270	COG1131	(ABC) transporter
I0U46_RS13275	COG0288	reversible hydration of carbon dioxide
I0U46_RS13285	COG2132	Multicopper oxidase
I0U46_RS13320	COG5441	Belongs to the UPF0261 family
I0U46_RS13325	COG5564	TIM-barrel signal transduction protein
I0U46_RS13330	COG0673	inositol 2-dehydrogenase activity
I0U46_RS13335	COG0534	Mate efflux family protein
I0U46_RS13345	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0U46_RS13350	COG3069	C4-dicarboxylate transmembrane transporter activity
I0U46_RS13360	COG0523	cobalamin synthesis protein
I0U46_RS13365	COG2879	small protein
I0U46_RS13370	COG1966	Carbon starvation protein
I0U46_RS13375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I0U46_RS13380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I0U46_RS13390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0U46_RS13405	COG1196	nuclear chromosome segregation
I0U46_RS13405	COG3264	Mechanosensitive ion channel
I0U46_RS13410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I0U46_RS13415	COG1309	transcriptional regulator
I0U46_RS13420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0U46_RS13425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0U46_RS13445	COG1946	Acyl-CoA thioesterase
I0U46_RS13450	COG0004	ammonium transporteR
I0U46_RS13455	COG0347	Belongs to the P(II) protein family
I0U46_RS13460	COG1132	(ABC) transporter
I0U46_RS13465	COG1132	(ABC) transporter
I0U46_RS13470	COG1522	sequence-specific DNA binding
I0U46_RS13475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I0U46_RS13480	COG0824	Thioesterase
I0U46_RS13485	COG1555	photosystem II stabilization
I0U46_RS13485	COG1596	polysaccharide export
I0U46_RS13490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0U46_RS13495	COG0776	regulation of translation
I0U46_RS13500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I0U46_RS13505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I0U46_RS13510	COG0740	serine-type endopeptidase activity
I0U46_RS13515	COG0544	peptidyl-prolyl cis-trans isomerase activity
I0U46_RS13520	COG0271	Belongs to the BolA IbaG family
I0U46_RS13525	COG3056	Lipoprotein
I0U46_RS13530	COG2223	nitrite transmembrane transporter activity
I0U46_RS13535	COG0513	Belongs to the DEAD box helicase family
I0U46_RS13545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0U46_RS13550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0U46_RS13555	COG1845	cytochrome c oxidase, subunit III
I0U46_RS13560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I0U46_RS13565	COG0109	protoheme IX farnesyltransferase activity
I0U46_RS13570	COG2814	Major facilitator Superfamily
I0U46_RS13575	COG1666	GTP binding
I0U46_RS13580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0U46_RS13585	COG0693	protein deglycase activity
I0U46_RS13600	COG0301	tRNA thio-modification
I0U46_RS13600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0U46_RS13610	COG0142	geranyltranstransferase activity
I0U46_RS13615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I0U46_RS13620	COG1869	D-ribose catabolic process
I0U46_RS13625	COG1129	ABC transporter
I0U46_RS13630	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0U46_RS13635	COG1879	ABC-type sugar transport system periplasmic component
I0U46_RS13640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0U46_RS13645	COG1609	Transcriptional regulator
I0U46_RS13660	COG2824	Alkylphosphonate utilization operon protein PhnA
I0U46_RS13670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0U46_RS13675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I0U46_RS13680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0U46_RS13680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0U46_RS13685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I0U46_RS13690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0U46_RS13695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0U46_RS13700	COG1862	Preprotein translocase
I0U46_RS13705	COG0343	queuine tRNA-ribosyltransferase activity
I0U46_RS13710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I0U46_RS13715	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I0U46_RS13720	COG0450	alkyl hydroperoxide reductase
I0U46_RS13730	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS13735	COG2414	aldehyde ferredoxin oxidoreductase
I0U46_RS13745	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS13750	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I0U46_RS13780	COG1114	Component of the transport system for branched-chain amino acids
I0U46_RS13785	COG5002	protein histidine kinase activity
I0U46_RS13795	COG0420	3'-5' exonuclease activity
I0U46_RS13800	COG0419	ATPase involved in DNA repair
I0U46_RS13810	COG0737	Belongs to the 5'-nucleotidase family
I0U46_RS13815	COG3719	Belongs to the RNase T2 family
I0U46_RS13820	COG0737	Belongs to the 5'-nucleotidase family
I0U46_RS13830	COG2974	May be involved in recombination
I0U46_RS13835	COG0425	Belongs to the sulfur carrier protein TusA family
I0U46_RS13840	COG2391	methyltransferase activity
I0U46_RS13845	COG0309	Hydrogenase expression formation protein (HypE)
I0U46_RS13850	COG0409	Hydrogenase expression formation protein
I0U46_RS13855	COG0298	carbon dioxide binding
I0U46_RS13860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I0U46_RS13865	COG1773	rubredoxin
I0U46_RS13870	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I0U46_RS13875	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I0U46_RS13880	COG5557	Pfam Polysulphide reductase, NrfD
I0U46_RS13885	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS13890	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I0U46_RS13895	COG0848	biopolymer transport protein
I0U46_RS13900	COG0811	peptide transport
I0U46_RS13905	COG0626	cystathionine gamma-synthase activity
I0U46_RS13915	COG2226	methyltransferase
I0U46_RS13920	COG1979	alcohol dehydrogenase
I0U46_RS13930	COG1388	LysM domain
I0U46_RS13930	COG1470	cell adhesion involved in biofilm formation
I0U46_RS13950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I0U46_RS13955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I0U46_RS13960	COG1047	Peptidyl-prolyl cis-trans
I0U46_RS13965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I0U46_RS13970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I0U46_RS13975	COG0196	riboflavin kinase activity
I0U46_RS13980	COG0268	Binds directly to 16S ribosomal RNA
I0U46_RS13985	COG0583	DNA-binding transcription factor activity
I0U46_RS13990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I0U46_RS13995	COG0484	heat shock protein binding
I0U46_RS14000	COG0443	Heat shock 70 kDa protein
I0U46_RS14005	COG0521	Mo-molybdopterin cofactor biosynthetic process
I0U46_RS14015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I0U46_RS14020	COG3022	response to hydroperoxide
I0U46_RS14035	COG0083	homoserine kinase activity
I0U46_RS14045	COG0745	RESPONSE REGULATOR receiver
I0U46_RS14050	COG3045	CreA protein
I0U46_RS14055	COG2207	Transcriptional regulator
I0U46_RS14055	COG3708	Transcriptional regulator
I0U46_RS14060	COG0406	alpha-ribazole phosphatase activity
I0U46_RS14065	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I0U46_RS14070	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I0U46_RS14075	COG0741	lytic transglycosylase activity
I0U46_RS14080	COG0488	(ABC) transporter
I0U46_RS14090	COG1595	DNA-templated transcription, initiation
I0U46_RS14100	COG4771	TonB-dependent receptor
I0U46_RS14105	COG4178	(ABC) transporter
I0U46_RS14110	COG0612	Peptidase, M16
I0U46_RS14120	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0U46_RS14120	COG1902	pentaerythritol trinitrate reductase activity
I0U46_RS14125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I0U46_RS14130	COG0586	Pfam SNARE associated Golgi protein
I0U46_RS14135	COG4575	ribosome binding
I0U46_RS14140	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I0U46_RS14150	COG2259	Doxx family
I0U46_RS14155	COG0583	DNA-binding transcription factor activity
I0U46_RS14160	COG1741	Belongs to the pirin family
I0U46_RS14170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I0U46_RS14180	COG0792	nuclease activity
I0U46_RS14185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I0U46_RS14190	COG2823	Periplasmic or secreted lipoprotein
I0U46_RS14195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I0U46_RS14200	COG0830	nickel cation binding
I0U46_RS14205	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I0U46_RS14210	COG0804	urea catabolic process
I0U46_RS14215	COG0832	Belongs to the urease beta subunit family
I0U46_RS14220	COG0831	urea catabolic process
I0U46_RS14225	COG0829	nickel cation binding
I0U46_RS14230	COG2207	Transcriptional regulator
I0U46_RS14235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0U46_RS14240	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I0U46_RS14245	COG2198	Histidine kinase
I0U46_RS14245	COG0784	Response regulator, receiver
I0U46_RS14245	COG5002	protein histidine kinase activity
I0U46_RS14250	COG0070	glutamate synthase
I0U46_RS14250	COG0069	glutamate synthase activity
I0U46_RS14250	COG0067	glutamate synthase
I0U46_RS14255	COG0493	'glutamate synthase
I0U46_RS14260	COG3069	C4-dicarboxylate transmembrane transporter activity
I0U46_RS14265	COG1473	amidohydrolase
I0U46_RS14275	COG2969	positive regulation of protein catabolic process
I0U46_RS14280	COG0625	glutathione transferase activity
I0U46_RS14285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I0U46_RS14290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I0U46_RS14295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I0U46_RS14300	COG3105	Protein conserved in bacteria
I0U46_RS14305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0U46_RS14310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0U46_RS14330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I0U46_RS14335	COG5007	Belongs to the BolA IbaG family
I0U46_RS14345	COG2854	intermembrane phospholipid transfer
I0U46_RS14350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I0U46_RS14355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I0U46_RS14360	COG1127	ABC transporter
I0U46_RS14365	COG0530	calcium, potassium:sodium antiporter activity
I0U46_RS14370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I0U46_RS14370	COG0517	IMP dehydrogenase activity
I0U46_RS14375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I0U46_RS14380	COG3117	lipopolysaccharide transmembrane transporter activity
I0U46_RS14385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I0U46_RS14390	COG1137	ATPase activity
I0U46_RS14395	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I0U46_RS14400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I0U46_RS14410	COG1660	Displays ATPase and GTPase activities
I0U46_RS14415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0U46_RS14420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0U46_RS14425	COG0312	modulator of DNA gyrase
I0U46_RS14430	COG3028	Belongs to the UPF0307 family
I0U46_RS14435	COG2732	(Barnase) inhibitor
I0U46_RS14445	COG0312	modulator of DNA gyrase
I0U46_RS14450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0U46_RS14455	COG3164	Protein of unknown function
I0U46_RS14460	COG1530	ribonuclease E activity
I0U46_RS14465	COG0424	maF-like protein
I0U46_RS14470	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I0U46_RS14475	COG1792	Involved in formation and maintenance of cell shape
I0U46_RS14480	COG1077	Cell shape determining protein MreB Mrl
I0U46_RS14485	COG0604	alcohol dehydrogenase
I0U46_RS14490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I0U46_RS14495	COG0511	ligase activity, forming carbon-carbon bonds
I0U46_RS14500	COG0439	Biotin carboxylase
I0U46_RS14505	COG3924	membrane
I0U46_RS14510	COG4145	pantothenate transmembrane transporter activity
I0U46_RS14515	COG2264	protein methyltransferase activity
I0U46_RS14520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0U46_RS14525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I0U46_RS14550	COG2807	transmembrane transport
I0U46_RS14555	COG0584	glycerophosphoryl diester phosphodiesterase
I0U46_RS14560	COG1653	transport
I0U46_RS14570	COG0395	ABC-type sugar transport system, permease component
I0U46_RS14575	COG3842	ATPase activity
I0U46_RS14580	COG0501	Belongs to the peptidase M48B family
I0U46_RS14585	COG1846	Transcriptional regulator
I0U46_RS14590	COG2814	Major facilitator Superfamily
I0U46_RS14600	COG1929	Belongs to the glycerate kinase type-1 family
I0U46_RS14610	COG2177	Part of the ABC transporter FtsEX involved in
I0U46_RS14615	COG2884	Cell division ATP-binding protein ftsE
I0U46_RS14620	COG0552	protein localization to endoplasmic reticulum
I0U46_RS14625	COG0742	ribosomal rna small subunit methyltransferase
I0U46_RS14630	COG3776	membrane
I0U46_RS14640	COG3714	YhhN family
I0U46_RS14645	COG2217	Heavy metal translocating P-type atpase
I0U46_RS14660	COG0675	Transposase, IS605 OrfB family
I0U46_RS14670	COG0425	Belongs to the sulfur carrier protein TusA family
I0U46_RS14675	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I0U46_RS14685	COG0247	lactate metabolic process
I0U46_RS14695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I0U46_RS14700	COG2271	Major facilitator Superfamily
I0U46_RS14705	COG0584	glycerophosphoryl diester phosphodiesterase
I0U46_RS14710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I0U46_RS14715	COG1053	succinate dehydrogenase
I0U46_RS14720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I0U46_RS14725	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I0U46_RS14730	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I0U46_RS14735	COG2076	Multidrug Resistance protein
I0U46_RS14740	COG0298	carbon dioxide binding
I0U46_RS14745	COG0375	protein maturation
I0U46_RS14750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I0U46_RS14755	COG3604	Transcriptional regulator
I0U46_RS14770	COG2194	sulfuric ester hydrolase activity
I0U46_RS14775	COG1304	FMN binding
I0U46_RS14780	COG2181	nitrate reductase activity
I0U46_RS14785	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I0U46_RS14790	COG1140	nitrate reductase beta subunit
I0U46_RS14795	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I0U46_RS14800	COG2223	nitrite transmembrane transporter activity
I0U46_RS14805	COG3850	Histidine kinase
I0U46_RS14810	COG2197	response regulator
I0U46_RS14815	COG0583	DNA-binding transcription factor activity
I0U46_RS14830	COG0730	response to heat
I0U46_RS14835	COG4770	biotin carboxylase activity
I0U46_RS14840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I0U46_RS14845	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I0U46_RS14850	COG1914	H( )-stimulated, divalent metal cation uptake system
I0U46_RS14885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0U46_RS14890	COG1739	Uncharacterized protein family UPF0029
I0U46_RS14895	COG0006	proline dipeptidase activity
I0U46_RS14900	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0U46_RS14900	COG1024	Enoyl-CoA hydratase
I0U46_RS14905	COG0183	Belongs to the thiolase family
I0U46_RS14915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I0U46_RS14930	COG0805	protein transport
I0U46_RS14935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I0U46_RS14940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I0U46_RS14950	COG3165	ubiquinone biosynthetic process from chorismate
I0U46_RS14955	COG2226	methyltransferase
I0U46_RS14960	COG1322	Protein conserved in bacteria
I0U46_RS14965	COG0586	Pfam SNARE associated Golgi protein
I0U46_RS14970	COG2365	Tyrosine phosphatase family
I0U46_RS14980	COG3753	Protein conserved in bacteria
I0U46_RS14990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I0U46_RS14995	COG0583	DNA-binding transcription factor activity
I0U46_RS15005	COG0025	NhaP-type Na H and K H
I0U46_RS15010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0U46_RS15015	COG2252	PERMEase
I0U46_RS15035	COG0440	acetolactate synthase activity
I0U46_RS15040	COG0028	Belongs to the TPP enzyme family
I0U46_RS15060	COG1263	PTS System
I0U46_RS15060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS15065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I0U46_RS15075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I0U46_RS15080	COG1349	DNA-binding transcription factor activity
I0U46_RS15085	COG1690	Belongs to the RtcB family
I0U46_RS15090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I0U46_RS15105	COG0675	Transposase, IS605 OrfB family
I0U46_RS15115	COG0459	protein refolding
I0U46_RS15120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I0U46_RS15135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I0U46_RS15140	COG1309	transcriptional regulator
I0U46_RS15155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I0U46_RS15160	COG1704	LemA family
I0U46_RS15175	COG2255	four-way junction helicase activity
I0U46_RS15180	COG4977	sequence-specific DNA binding
I0U46_RS15185	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I0U46_RS15190	COG0644	oxidoreductase
I0U46_RS15195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I0U46_RS15200	COG2086	electron transfer activity
I0U46_RS15205	COG1960	acyl-CoA dehydrogenase activity
I0U46_RS15210	COG2610	gluconate transmembrane transporter activity
I0U46_RS15225	COG1924	4 iron, 4 sulfur cluster binding
I0U46_RS15235	COG0318	PFAM AMP-dependent synthetase and ligase
I0U46_RS15240	COG2271	Major facilitator Superfamily
I0U46_RS15245	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I0U46_RS15250	COG0644	oxidoreductase
I0U46_RS15270	COG1960	acyl-CoA dehydrogenase activity
I0U46_RS15275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I0U46_RS15280	COG0318	PFAM AMP-dependent synthetase and ligase
I0U46_RS15285	COG1024	Enoyl-CoA hydratase
I0U46_RS15305	COG3397	chitin binding
I0U46_RS15310	COG2137	regulation of response to DNA damage stimulus
I0U46_RS15330	COG2992	FlgJ-related protein
I0U46_RS15355	COG2610	gluconate transmembrane transporter activity
I0U46_RS15360	COG3265	gluconokinase activity
I0U46_RS15365	COG1609	Transcriptional regulator
I0U46_RS15370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0U46_RS15375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0U46_RS15380	COG1120	ATPase activity
I0U46_RS15385	COG0500	methyltransferase
I0U46_RS15390	COG0157	Belongs to the NadC ModD family
I0U46_RS15435	COG4790	Type iii secretion
I0U46_RS15480	COG2207	Transcriptional regulator
I0U46_RS15520	COG0789	Transcriptional regulator
I0U46_RS15535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0U46_RS15560	COG4869	propanediol catabolic process
I0U46_RS15570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I0U46_RS15575	COG1882	Formate acetyltransferase
I0U46_RS15585	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I0U46_RS15590	COG1012	belongs to the aldehyde dehydrogenase family
I0U46_RS15590	COG1454	alcohol dehydrogenase
I0U46_RS15625	COG2873	o-acetylhomoserine
I0U46_RS15645	COG3188	usher protein
I0U46_RS15650	COG3539	Fimbrial protein
I0U46_RS15670	COG1177	transmembrane transport
I0U46_RS15690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0U46_RS15710	COG1448	Aminotransferase
I0U46_RS15720	COG0814	amino acid
I0U46_RS15725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I0U46_RS15735	COG0735	belongs to the Fur family
I0U46_RS15740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I0U46_RS15745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I0U46_RS15750	COG2937	Belongs to the GPAT DAPAT family
I0U46_RS15755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I0U46_RS15760	COG3161	chorismate lyase activity
I0U46_RS15765	COG0166	Belongs to the GPI family
I0U46_RS15770	COG0527	aspartate kinase activity
I0U46_RS15785	COG0646	methionine synthase
I0U46_RS15785	COG1410	methionine synthase
I0U46_RS15795	COG0129	dihydroxy-acid dehydratase activity
I0U46_RS15800	COG0800	Aldolase
I0U46_RS15810	COG2224	Isocitrate lyase
I0U46_RS15815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I0U46_RS15820	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I0U46_RS15830	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I0U46_RS15860	COG0138	bifunctional purine biosynthesis protein purh
I0U46_RS15865	COG0151	Belongs to the GarS family
I0U46_RS15880	COG3068	Protein conserved in bacteria
I0U46_RS15885	COG1515	deoxyribonuclease V activity
I0U46_RS15890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I0U46_RS15895	COG2816	NAD+ diphosphatase activity
I0U46_RS15905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I0U46_RS15910	COG0352	thiamine-phosphate diphosphorylase activity
I0U46_RS15915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0U46_RS15920	COG2104	thiamine diphosphate biosynthetic process
I0U46_RS15925	COG2022	thiamine diphosphate biosynthetic process
I0U46_RS15935	COG5464	transposase or invertase
I0U46_RS15940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I0U46_RS15945	COG0085	RNA polymerase activity
I0U46_RS15950	COG0222	ribosome binding
I0U46_RS15955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I0U46_RS15960	COG0081	regulation of translation
I0U46_RS15965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I0U46_RS15970	COG0250	Participates in transcription elongation, termination and antitermination
I0U46_RS15985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I0U46_RS15990	COG0049	tRNA binding
I0U46_RS15995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I0U46_RS16005	COG2923	Belongs to the DsrF TusC family
I0U46_RS16010	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I0U46_RS16015	COG2964	Protein conserved in bacteria
I0U46_RS16025	COG0545	Peptidyl-prolyl cis-trans isomerase
I0U46_RS16030	COG2900	Belongs to the SlyX family
I0U46_RS16035	COG1047	Peptidyl-prolyl cis-trans
I0U46_RS16040	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I0U46_RS16050	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0U46_RS16055	COG0488	(ABC) transporter
I0U46_RS16060	COG0840	transmembrane signaling receptor activity
I0U46_RS16065	COG0840	transmembrane signaling receptor activity
I0U46_RS16070	COG0840	transmembrane signaling receptor activity
I0U46_RS16085	COG0429	hydrolase of the alpha beta-hydrolase fold
I0U46_RS16090	COG3089	Belongs to the UPF0270 family
I0U46_RS16095	COG3954	Phosphoribulokinase
I0U46_RS16100	COG1765	OsmC-like protein
I0U46_RS16105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0U46_RS16110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0U46_RS16120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I0U46_RS16130	COG0242	peptide deformylase activity
I0U46_RS16135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0U46_RS16135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0U46_RS16145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0U46_RS16150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0U46_RS16155	COG3084	Protein conserved in bacteria
I0U46_RS16160	COG0746	molybdenum cofactor guanylyltransferase activity
I0U46_RS16165	COG1763	Mo-molybdopterin cofactor biosynthetic process
I0U46_RS16180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0U46_RS16185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I0U46_RS16195	COG1295	ribonuclease BN
I0U46_RS16200	COG1942	4-Oxalocrotonate Tautomerase
I0U46_RS16210	COG2200	EAL domain
I0U46_RS16210	COG2199	diguanylate cyclase activity
I0U46_RS16215	COG3210	domain, Protein
I0U46_RS16220	COG4608	Belongs to the ABC transporter superfamily
I0U46_RS16225	COG0444	Belongs to the ABC transporter superfamily
I0U46_RS16230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0U46_RS16235	COG0601	transmembrane transport
I0U46_RS16240	COG0747	negative chemotaxis
I0U46_RS16245	COG2831	hemolysin activation secretion protein
I0U46_RS16260	COG5645	(Lipo)protein
I0U46_RS16265	COG0569	domain protein
I0U46_RS16265	COG2985	domain, Protein
I0U46_RS16270	COG3977	Valine--pyruvate aminotransferase
I0U46_RS16275	COG2818	Glycosylase
I0U46_RS16280	COG0752	glycyl-tRNA synthetase alpha subunit
I0U46_RS16285	COG0751	glycine-tRNA ligase activity
I0U46_RS16310	COG0823	Involved in the tonB-independent uptake of proteins
I0U46_RS16315	COG2860	membrane
I0U46_RS16320	COG0194	GDP metabolic process
I0U46_RS16325	COG1758	RNA polymerase activity
I0U46_RS16330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0U46_RS16335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0U46_RS16340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I0U46_RS16345	COG0786	glutamate:sodium symporter activity
I0U46_RS16350	COG2233	PERMEase
I0U46_RS16355	COG2982	Protein involved in outer membrane biogenesis
I0U46_RS16365	COG1187	pseudouridine synthase activity
I0U46_RS16370	COG0456	acetyltransferase
I0U46_RS16375	COG1490	D-aminoacyl-tRNA deacylase activity
I0U46_RS16380	COG1011	Hydrolase
I0U46_RS16400	COG1217	gtp-binding protein TYPA
I0U46_RS16440	COG2183	response to ionizing radiation
I0U46_RS16445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0U46_RS16460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0U46_RS16465	COG0573	inorganic phosphate transmembrane transporter activity
I0U46_RS16470	COG0581	inorganic phosphate transmembrane transporter activity
I0U46_RS16480	COG0704	Plays a role in the regulation of phosphate uptake
I0U46_RS16485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0U46_RS16490	COG0765	amino acid transport
I0U46_RS16495	COG0765	amino acid transport
I0U46_RS16520	COG1136	(ABC) transporter
I0U46_RS16535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0U46_RS16540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0U46_RS16545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0U46_RS16550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0U46_RS16555	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS16560	COG0736	holo-[acyl-carrier-protein] synthase activity
I0U46_RS16570	COG2252	PERMEase
I0U46_RS16575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0U46_RS16595	COG1918	ferrous iron import across plasma membrane
I0U46_RS16600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0U46_RS16615	COG2267	carboxylic ester hydrolase activity
I0U46_RS16620	COG1040	competence protein
I0U46_RS16625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I0U46_RS16625	COG0316	Belongs to the HesB IscA family
I0U46_RS16630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0U46_RS16635	COG0705	Rhomboid family
I0U46_RS16640	COG1349	DNA-binding transcription factor activity
I0U46_RS16645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I0U46_RS16650	COG3189	MarR family transcriptional regulator
I0U46_RS16690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0U46_RS16700	COG1069	ribulokinase activity
I0U46_RS16710	COG1124	(ABC) transporter
I0U46_RS16725	COG0601	transmembrane transport
I0U46_RS16730	COG0747	negative chemotaxis
I0U46_RS16735	COG2226	methyltransferase
I0U46_RS16750	COG3394	polysaccharide catabolic process
I0U46_RS16755	COG1486	melibiose metabolic process
I0U46_RS16760	COG1917	Cupin 2, conserved barrel domain protein
I0U46_RS16760	COG2169	Transcriptional regulator
I0U46_RS16765	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0U46_RS16770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0U46_RS16775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0U46_RS16780	COG4607	ABC-type enterochelin transport system periplasmic component
I0U46_RS16785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0U46_RS16790	COG4605	iron ion homeostasis
I0U46_RS16795	COG4604	ABC transporter, ATP-binding protein
I0U46_RS16805	COG2271	Major facilitator Superfamily
I0U46_RS16810	COG4948	Mandelate Racemase Muconate Lactonizing
I0U46_RS16815	COG1802	Transcriptional regulator
I0U46_RS16820	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS16825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0U46_RS16830	COG0800	Aldolase
I0U46_RS16850	COG0243	molybdopterin cofactor binding
I0U46_RS16855	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS16860	COG3302	dmso reductase anchor subunit
I0U46_RS16865	COG1609	Transcriptional regulator
I0U46_RS16875	COG2211	Major facilitator Superfamily
I0U46_RS16880	COG1285	pathogenesis
I0U46_RS16900	COG1737	Transcriptional regulator
I0U46_RS16905	COG2731	YhcH YjgK YiaL family protein
I0U46_RS16910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0U46_RS16920	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I0U46_RS16925	COG3383	formate dehydrogenase (NAD+) activity
I0U46_RS16930	COG0733	neurotransmitter:sodium symporter activity
I0U46_RS16935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I0U46_RS16940	COG1263	PTS System
I0U46_RS16940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0U46_RS16945	COG1737	Transcriptional regulator
I0U46_RS16950	COG1278	Cold shock
I0U46_RS16955	COG0564	pseudouridine synthase activity
I0U46_RS16960	COG3122	Protein conserved in bacteria
I0U46_RS16980	COG3188	usher protein
I0U46_RS17025	COG0742	ribosomal rna small subunit methyltransferase
I0U46_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
I0U46_RS17040	COG0589	response to stress
I0U46_RS17050	COG0306	phosphate transporter
I0U46_RS17055	COG2081	HI0933 family
I0U46_RS17065	COG1741	Belongs to the pirin family
I0U46_RS17070	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I0U46_RS17075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I0U46_RS17080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I0U46_RS17090	COG0494	nUDIX hydrolase
I0U46_RS17100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0U46_RS17120	COG4796	Type ii and iii secretion system protein
I0U46_RS17125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I0U46_RS17130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I0U46_RS17145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I0U46_RS17150	COG0546	phosphoglycolate phosphatase activity
I0U46_RS17155	COG0180	Tryptophanyl-tRNA synthetase
I0U46_RS17160	COG0675	Transposase, IS605 OrfB family
I0U46_RS17170	COG2258	MOSC domain
I0U46_RS17175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0U46_RS17180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0U46_RS17185	COG3162	membrane
I0U46_RS17190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0U46_RS17195	COG2194	sulfuric ester hydrolase activity
I0U46_RS17200	COG1556	Lactate utilization protein
I0U46_RS17205	COG1139	Iron-sulfur cluster binding protein
I0U46_RS17210	COG0247	lactate metabolic process
I0U46_RS17235	COG2186	Transcriptional regulator
I0U46_RS17240	COG0477	Major facilitator Superfamily
I0U46_RS17245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0U46_RS17250	COG0714	Associated with various cellular activities
I0U46_RS17255	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I0U46_RS17260	COG2502	aspartate--ammonia ligase
I0U46_RS17265	COG1522	sequence-specific DNA binding
I0U46_RS17270	COG0716	FMN binding
I0U46_RS17275	COG0445	tRNA wobble uridine modification
I0U46_RS17280	COG0357	Ribosomal RNA small subunit methyltransferase G
I0U46_RS17285	COG3312	ion transport
I0U46_RS17290	COG0356	it plays a direct role in the translocation of protons across the membrane
I0U46_RS17300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I0U46_RS17305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I0U46_RS17310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I0U46_RS17315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I0U46_RS17320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I0U46_RS17325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I0U46_RS17330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I0U46_RS17335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I0U46_RS17340	COG3842	ATPase activity
I0U46_RS17345	COG1178	ABC-type Fe3 transport system permease component
I0U46_RS17350	COG1840	ABC-type Fe3 transport system, periplasmic component
I0U46_RS17355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0U46_RS17370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0U46_RS17380	COG1288	antiporter activity
I0U46_RS17415	COG3188	usher protein
I0U46_RS17440	COG3111	PFAM Bacterial OB fold (BOF) protein
I0U46_RS17450	COG1940	carbohydrate kinase activity
I0U46_RS17460	COG1215	transferase activity, transferring glycosyl groups
I0U46_RS17470	COG0457	Tetratricopeptide repeat
I0U46_RS17480	COG3706	GGDEF domain
I0U46_RS17485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0U46_RS17490	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I0U46_RS17495	COG1368	sulfuric ester hydrolase activity
I0U46_RS17500	COG3276	selenocysteine insertion sequence binding
I0U46_RS17505	COG1921	L-seryl-tRNASec selenium transferase activity
I0U46_RS17510	COG3058	Necessary for formate dehydrogenase activity
I0U46_RS17515	COG2864	formate dehydrogenase
I0U46_RS17520	COG0437	4 iron, 4 sulfur cluster binding
I0U46_RS17530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0U46_RS17545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0U46_RS17550	COG0583	DNA-binding transcription factor activity
I0U46_RS17590	COG3550	peptidyl-serine autophosphorylation
I0U46_RS17750	COG0464	growth
I0U46_RS17765	COG1074	ATP-dependent DNA helicase activity
I0U46_RS17845	COG4974	Belongs to the 'phage' integrase family
I0U46_RS17850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I0U46_RS17855	COG0706	membrane insertase activity
I0U46_RS17860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I0U46_RS17865	COG0594	ribonuclease P activity
I0U46_RS17870	COG0230	Belongs to the bacterial ribosomal protein bL34 family