locus-tag	class	description
I6G31_RS00010	COG3121	Chaperone
I6G31_RS00020	COG3152	Membrane
I6G31_RS00030	COG1294	oxidase, subunit
I6G31_RS00040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G31_RS00065	COG0583	DNA-binding transcription factor activity
I6G31_RS00070	COG0579	oxidoreductase
I6G31_RS00075	COG2186	Transcriptional regulator
I6G31_RS00095	COG1122	ATPase activity
I6G31_RS00130	COG3527	Alpha-acetolactate decarboxylase
I6G31_RS00170	COG0012	GTP binding
I6G31_RS00175	COG0193	aminoacyl-tRNA hydrolase activity
I6G31_RS00185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G31_RS00190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G31_RS00195	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G31_RS00200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G31_RS00205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G31_RS00210	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G31_RS00220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G31_RS00225	COG1242	4 iron, 4 sulfur cluster binding
I6G31_RS00230	COG0659	secondary active sulfate transmembrane transporter activity
I6G31_RS00240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G31_RS00255	COG3381	protein complex oligomerization
I6G31_RS00265	COG0477	Major facilitator Superfamily
I6G31_RS00270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G31_RS00275	COG0728	peptidoglycan biosynthetic process
I6G31_RS00285	COG0018	arginyl-trna synthetase
I6G31_RS00290	COG3102	Protein conserved in bacteria
I6G31_RS00295	COG3142	Participates in the control of copper homeostasis
I6G31_RS00300	COG0488	(ABC) transporter
I6G31_RS00310	COG0500	methyltransferase
I6G31_RS00315	COG2226	methyltransferase
I6G31_RS00320	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6G31_RS00325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G31_RS00330	COG0494	nUDIX hydrolase
I6G31_RS00335	COG0217	transcriptional regulatory protein
I6G31_RS00340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G31_RS00345	COG0632	four-way junction helicase activity
I6G31_RS00350	COG2255	four-way junction helicase activity
I6G31_RS00355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G31_RS00360	COG1121	(ABC) transporter
I6G31_RS00365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G31_RS00370	COG0739	heme binding
I6G31_RS00375	COG1560	Kdo2-lipid A biosynthetic process
I6G31_RS00380	COG0469	pyruvate kinase activity
I6G31_RS00385	COG1737	Transcriptional regulator
I6G31_RS00390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G31_RS00395	COG2076	Multidrug Resistance protein
I6G31_RS00400	COG2076	Multidrug Resistance protein
I6G31_RS00405	COG0702	epimerase
I6G31_RS00410	COG0251	oxidation-reduction process
I6G31_RS00415	COG1199	ATP-dependent helicase activity
I6G31_RS00425	COG3065	identical protein binding
I6G31_RS00430	COG0318	PFAM AMP-dependent synthetase and ligase
I6G31_RS00435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6G31_RS00440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G31_RS00445	COG2894	cell division
I6G31_RS00450	COG0850	regulation of cytokinetic process
I6G31_RS00455	COG3100	YcgL domain-containing protein
I6G31_RS00465	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G31_RS00470	COG2983	Belongs to the UPF0260 family
I6G31_RS00475	COG0390	transport system, permease component
I6G31_RS00480	COG4619	ABC transporter
I6G31_RS00490	COG3708	Transcriptional regulator
I6G31_RS00490	COG2207	Transcriptional regulator
I6G31_RS00510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G31_RS00525	COG3784	Protein of unknown function (DUF1318)
I6G31_RS00535	COG3188	usher protein
I6G31_RS00555	COG1643	Atp-dependent helicase
I6G31_RS00560	COG0531	amino acid
I6G31_RS00570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G31_RS00575	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G31_RS00580	COG0589	response to stress
I6G31_RS00585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G31_RS00590	COG0243	molybdopterin cofactor binding
I6G31_RS00595	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS00610	COG3321	synthase
I6G31_RS00610	COG0604	alcohol dehydrogenase
I6G31_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
I6G31_RS00620	COG1695	Transcriptional regulator
I6G31_RS00680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G31_RS00685	COG4974	Belongs to the 'phage' integrase family
I6G31_RS00690	COG1446	asparaginase
I6G31_RS00695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G31_RS00700	COG0842	Transport permease protein
I6G31_RS00700	COG1129	ABC transporter
I6G31_RS00705	COG0842	Transport permease protein
I6G31_RS00720	COG0745	RESPONSE REGULATOR receiver
I6G31_RS00725	COG2205	protein histidine kinase activity
I6G31_RS00735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G31_RS00740	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G31_RS00750	COG0666	response to abiotic stimulus
I6G31_RS00755	COG0590	tRNA wobble adenosine to inosine editing
I6G31_RS00760	COG3381	protein complex oligomerization
I6G31_RS00765	COG3302	dmso reductase anchor subunit
I6G31_RS00770	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS00775	COG0243	molybdopterin cofactor binding
I6G31_RS00825	COG2376	Dihydroxyacetone kinase
I6G31_RS00835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G31_RS00850	COG0058	SHG alpha-glucan phosphorylase activity
I6G31_RS00860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G31_RS00865	COG1523	belongs to the glycosyl hydrolase 13 family
I6G31_RS00870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G31_RS00875	COG0583	DNA-binding transcription factor activity
I6G31_RS00905	COG2169	Transcriptional regulator
I6G31_RS00905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G31_RS00915	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G31_RS00930	COG1464	Belongs to the NlpA lipoprotein family
I6G31_RS00955	COG2814	Major facilitator Superfamily
I6G31_RS00965	COG0583	DNA-binding transcription factor activity
I6G31_RS00975	COG1309	transcriptional regulator
I6G31_RS00990	COG0488	(ABC) transporter
I6G31_RS00995	COG1671	Belongs to the UPF0178 family
I6G31_RS01005	COG0402	S-adenosylhomocysteine deaminase activity
I6G31_RS01025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G31_RS01040	COG1289	transmembrane transporter activity
I6G31_RS01050	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6G31_RS01060	COG0443	Heat shock 70 kDa protein
I6G31_RS01085	COG1757	Na H antiporter
I6G31_RS01090	COG0436	Aminotransferase
I6G31_RS01095	COG2207	Transcriptional regulator
I6G31_RS01095	COG1609	Transcriptional regulator
I6G31_RS01100	COG4628	conserved protein (DUF2132)
I6G31_RS01105	COG2814	Major facilitator Superfamily
I6G31_RS01115	COG2850	peptidyl-arginine hydroxylation
I6G31_RS01125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G31_RS01130	COG0640	Transcriptional regulator
I6G31_RS01145	COG4221	oxidoreductase activity
I6G31_RS01160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G31_RS01165	COG1940	carbohydrate kinase activity
I6G31_RS01170	COG0583	DNA-binding transcription factor activity
I6G31_RS01175	COG2814	Major facilitator Superfamily
I6G31_RS01190	COG0114	fumarate hydratase activity
I6G31_RS01205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G31_RS01210	COG0385	Bile acid
I6G31_RS01215	COG0673	inositol 2-dehydrogenase activity
I6G31_RS01225	COG4657	Part of a membrane complex involved in electron transport
I6G31_RS01235	COG4656	Part of a membrane complex involved in electron transport
I6G31_RS01245	COG4659	FMN binding
I6G31_RS01255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G31_RS01260	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6G31_RS01265	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6G31_RS01270	COG0023	Translation Initiation Factor
I6G31_RS01275	COG0284	orotidine-5'-phosphate decarboxylase activity
I6G31_RS01280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G31_RS01285	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6G31_RS01290	COG0671	phosphoesterase, PA-phosphatase related
I6G31_RS01295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G31_RS01305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G31_RS01315	COG0583	DNA-binding transcription factor activity
I6G31_RS01325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G31_RS01335	COG0616	signal peptide processing
I6G31_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
I6G31_RS01355	COG1187	pseudouridine synthase activity
I6G31_RS01360	COG0009	L-threonylcarbamoyladenylate synthase
I6G31_RS01365	COG0613	PHP domain protein
I6G31_RS01370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G31_RS01375	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G31_RS01380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G31_RS01390	COG0133	tryptophan synthase activity
I6G31_RS01395	COG0159	tryptophan synthase activity
I6G31_RS01420	COG2917	probably involved in intracellular septation
I6G31_RS01440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G31_RS01475	COG0037	tRNA processing
I6G31_RS01480	COG0598	Magnesium transport protein CorA
I6G31_RS01495	COG4166	transmembrane transport
I6G31_RS01500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G31_RS01515	COG3768	UPF0283 membrane protein
I6G31_RS01520	COG3106	COG3106 Predicted ATPase
I6G31_RS01530	COG1983	PspC domain protein
I6G31_RS01540	COG1842	Phage shock protein A
I6G31_RS01545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G31_RS01550	COG4166	transmembrane transport
I6G31_RS01555	COG4168	peptide transport system, permease
I6G31_RS01560	COG4171	peptide transport system, permease
I6G31_RS01565	COG4172	Belongs to the ABC transporter superfamily
I6G31_RS01570	COG4172	Belongs to the ABC transporter superfamily
I6G31_RS01575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G31_RS01590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G31_RS01595	COG0259	pyridoxamine-phosphate oxidase activity
I6G31_RS01600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G31_RS01615	COG3313	Fe-S protein
I6G31_RS01620	COG0346	lactoylglutathione lyase activity
I6G31_RS01625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G31_RS01630	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G31_RS01635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G31_RS01645	COG0730	response to heat
I6G31_RS01660	COG1609	Transcriptional regulator
I6G31_RS01665	COG0583	DNA-binding transcription factor activity
I6G31_RS01670	COG2814	Major facilitator Superfamily
I6G31_RS01675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G31_RS01680	COG0307	riboflavin synthase, alpha
I6G31_RS01685	COG0534	Mate efflux family protein
I6G31_RS01720	COG1376	ErfK ybiS ycfS ynhG family protein
I6G31_RS01720	COG1388	LysM domain
I6G31_RS01725	COG2166	iron-sulfur cluster assembly
I6G31_RS01730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G31_RS01735	COG0719	Fe-S assembly protein
I6G31_RS01740	COG0396	ATPase activity
I6G31_RS01745	COG0719	Fe-S assembly protein
I6G31_RS01750	COG0316	Belongs to the HesB IscA family
I6G31_RS01760	COG2050	protein possibly involved in aromatic compounds catabolism
I6G31_RS01765	COG0247	lactate metabolic process
I6G31_RS01765	COG0277	FAD linked oxidase domain protein
I6G31_RS01770	COG0628	permease
I6G31_RS01775	COG0574	Belongs to the PEP-utilizing enzyme family
I6G31_RS01775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G31_RS01780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G31_RS01785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G31_RS01795	COG4771	TonB-dependent receptor
I6G31_RS01800	COG4771	TonB-dependent receptor
I6G31_RS01805	COG3720	iron ion transport
I6G31_RS01810	COG4558	Periplasmic binding protein
I6G31_RS01815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G31_RS01820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6G31_RS01825	COG2207	Transcriptional regulator
I6G31_RS01835	COG0791	NLP P60 protein
I6G31_RS01840	COG2076	Multidrug Resistance protein
I6G31_RS01845	COG2076	Multidrug Resistance protein
I6G31_RS01850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G31_RS01855	COG0726	polysaccharide deacetylase
I6G31_RS01860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G31_RS01860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G31_RS01865	COG0463	Glycosyl transferase, family 2
I6G31_RS01870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G31_RS01875	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6G31_RS01880	COG4139	cobalamin transport
I6G31_RS01885	COG0776	regulation of translation
I6G31_RS01890	COG0072	phenylalanine-tRNA ligase activity
I6G31_RS01890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G31_RS01895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G31_RS01905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G31_RS01910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G31_RS01915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G31_RS01920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G31_RS01930	COG4977	sequence-specific DNA binding
I6G31_RS01930	COG1917	Cupin 2, conserved barrel domain protein
I6G31_RS01935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G31_RS01955	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G31_RS01960	COG1121	(ABC) transporter
I6G31_RS01965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G31_RS01970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G31_RS01975	COG3001	Fructosamine kinase
I6G31_RS01985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G31_RS01995	COG1823	symporter activity
I6G31_RS02005	COG0501	Belongs to the peptidase M48B family
I6G31_RS02020	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6G31_RS02025	COG1956	GAF domain-containing protein
I6G31_RS02030	COG2995	paraquat-inducible protein a
I6G31_RS02035	COG3008	intermembrane lipid transfer
I6G31_RS02050	COG1276	copper resistance
I6G31_RS02055	COG2372	response to copper ion
I6G31_RS02060	COG1528	Iron-storage protein
I6G31_RS02080	COG0840	transmembrane signaling receptor activity
I6G31_RS02085	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G31_RS02090	COG1598	PFAM Uncharacterised protein family UPF0150
I6G31_RS02095	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6G31_RS02115	COG2841	Protein conserved in bacteria
I6G31_RS02150	COG3272	Protein of unknown function (DUF1722)
I6G31_RS02170	COG0500	methyltransferase
I6G31_RS02175	COG3969	phosphoadenosine phosphosulfate
I6G31_RS02180	COG1475	DNA binding
I6G31_RS02185	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G31_RS02190	COG1278	Cold shock
I6G31_RS02195	COG3477	response to acidic pH
I6G31_RS02205	COG0582	viral genome integration into host DNA
I6G31_RS02215	COG1078	dGTPase activity
I6G31_RS02315	COG4626	Terminase
I6G31_RS02315	COG1802	Transcriptional regulator
I6G31_RS02345	COG3772	lysozyme
I6G31_RS02385	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G31_RS02390	COG1278	Cold shock
I6G31_RS02410	COG1403	HNH endonuclease
I6G31_RS02420	COG1846	Transcriptional regulator
I6G31_RS02450	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G31_RS02460	COG0582	viral genome integration into host DNA
I6G31_RS02490	COG0210	DNA helicase
I6G31_RS02605	COG0740	serine-type endopeptidase activity
I6G31_RS02645	COG3772	lysozyme
I6G31_RS02655	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6G31_RS02670	COG3423	Transcriptional regulator
I6G31_RS02705	COG0582	viral genome integration into host DNA
I6G31_RS02710	COG0538	isocitrate dehydrogenase activity
I6G31_RS02715	COG1187	pseudouridine synthase activity
I6G31_RS02725	COG0482	sulfurtransferase activity
I6G31_RS02730	COG2915	High frequency lysogenization protein hflD homolog
I6G31_RS02735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G31_RS02740	COG0745	RESPONSE REGULATOR receiver
I6G31_RS02750	COG2850	peptidyl-arginine hydroxylation
I6G31_RS02770	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G31_RS02775	COG1136	(ABC) transporter
I6G31_RS02780	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G31_RS02785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G31_RS02790	COG3134	Outer membrane lipoprotein
I6G31_RS02795	COG1252	NADH dehydrogenase
I6G31_RS02805	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G31_RS02815	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6G31_RS02820	COG5633	Lipoprotein
I6G31_RS02825	COG0537	adenosine 5'-monophosphoramidase activity
I6G31_RS02830	COG0084	hydrolase, TatD family'
I6G31_RS02835	COG0470	DNA polymerase III
I6G31_RS02840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G31_RS02845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G31_RS02850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G31_RS02855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G31_RS02860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G31_RS02875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G31_RS02880	COG0416	fatty acid biosynthetic process
I6G31_RS02885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G31_RS02890	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G31_RS02895	COG0424	maF-like protein
I6G31_RS02905	COG0564	pseudouridine synthase activity
I6G31_RS02910	COG1530	ribonuclease E activity
I6G31_RS02915	COG2926	Belongs to the UPF0265 family
I6G31_RS02920	COG2211	Major facilitator Superfamily
I6G31_RS02925	COG2925	Exonuclease
I6G31_RS02930	COG0277	FAD linked oxidase domain protein
I6G31_RS02935	COG0583	DNA-binding transcription factor activity
I6G31_RS02940	COG3961	Belongs to the TPP enzyme family
I6G31_RS02980	COG3210	domain, Protein
I6G31_RS02980	COG3210	domain, Protein
I6G31_RS02985	COG2831	hemolysin activation secretion protein
I6G31_RS02990	COG0531	amino acid
I6G31_RS03000	COG1120	ATPase activity
I6G31_RS03005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G31_RS03010	COG0833	amino acid
I6G31_RS03015	COG0583	DNA-binding transcription factor activity
I6G31_RS03020	COG2855	membrane
I6G31_RS03025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6G31_RS03030	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G31_RS03035	COG0494	nUDIX hydrolase
I6G31_RS03045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G31_RS03065	COG0791	NLP P60 protein
I6G31_RS03075	COG2814	Major facilitator Superfamily
I6G31_RS03080	COG1187	pseudouridine synthase activity
I6G31_RS03085	COG1061	Type III restriction enzyme res subunit
I6G31_RS03090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G31_RS03095	COG3081	Nucleoid-associated protein
I6G31_RS03100	COG3082	Protein of unknown function (DUF1414)
I6G31_RS03105	COG3083	sulfuric ester hydrolase activity
I6G31_RS03155	COG1560	Kdo2-lipid A biosynthetic process
I6G31_RS03160	COG1278	Cold shock
I6G31_RS03180	COG2207	Transcriptional regulator
I6G31_RS03180	COG3708	Transcriptional regulator
I6G31_RS03195	COG1473	amidohydrolase
I6G31_RS03230	COG2920	part of a sulfur-relay system
I6G31_RS03235	COG1254	Belongs to the acylphosphatase family
I6G31_RS03240	COG3785	DNA binding
I6G31_RS03245	COG1832	CoA-binding protein
I6G31_RS03250	COG1803	Methylglyoxal synthase
I6G31_RS03255	COG0210	DNA helicase
I6G31_RS03260	COG1289	transmembrane transporter activity
I6G31_RS03275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G31_RS03275	COG2885	chlorophyll binding
I6G31_RS03280	COG3120	sequence-specific DNA binding
I6G31_RS03285	COG1067	ATP-dependent peptidase activity
I6G31_RS03290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G31_RS03295	COG3130	regulation of translation
I6G31_RS03305	COG3009	Protein conserved in bacteria
I6G31_RS03310	COG3008	intermembrane lipid transfer
I6G31_RS03310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G31_RS03315	COG2995	paraquat-inducible protein a
I6G31_RS03320	COG0488	(ABC) transporter
I6G31_RS03325	COG0116	Belongs to the methyltransferase superfamily
I6G31_RS03325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G31_RS03340	COG0167	dihydroorotate dehydrogenase activity
I6G31_RS03345	COG0308	aminopeptidase N
I6G31_RS03350	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G31_RS03355	COG0017	Asparaginyl-tRNA synthetase
I6G31_RS03360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G31_RS03365	COG1448	Aminotransferase
I6G31_RS03370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G31_RS03375	COG3108	Peptidase M15
I6G31_RS03380	COG2989	Protein conserved in bacteria
I6G31_RS03385	COG3700	Belongs to the class B bacterial acid phosphatase family
I6G31_RS03390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6G31_RS03395	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6G31_RS03400	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6G31_RS03405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G31_RS03410	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G31_RS03420	COG0579	oxidoreductase
I6G31_RS03430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G31_RS03435	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G31_RS03445	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G31_RS03450	COG1132	(ABC) transporter
I6G31_RS03455	COG2333	competence protein COMEC
I6G31_RS03455	COG0658	competence protein
I6G31_RS03460	COG0776	regulation of translation
I6G31_RS03465	COG0539	negative regulation of cytoplasmic translation
I6G31_RS03470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G31_RS03475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G31_RS03480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G31_RS03490	COG3210	domain, Protein
I6G31_RS03495	COG3210	domain, Protein
I6G31_RS03500	COG0252	asparaginase activity
I6G31_RS03505	COG1944	ATP diphosphatase activity
I6G31_RS03510	COG2116	formate transmembrane transporter activity
I6G31_RS03515	COG1882	Formate acetyltransferase
I6G31_RS03520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G31_RS03530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G31_RS03540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G31_RS03545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G31_RS03550	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G31_RS03555	COG3107	peptidoglycan biosynthetic process
I6G31_RS03555	COG1674	ftsk spoiiie
I6G31_RS03565	COG0492	ferredoxin-NADP+ reductase activity
I6G31_RS03575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G31_RS03580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G31_RS03585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G31_RS03590	COG0542	response to heat
I6G31_RS03595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G31_RS03600	COG1278	Cold shock
I6G31_RS03610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G31_RS03615	COG3593	DNA synthesis involved in DNA repair
I6G31_RS03620	COG2431	L-lysine efflux transmembrane transporter activity
I6G31_RS03625	COG0702	epimerase
I6G31_RS03630	COG1126	abc transporter atp-binding protein
I6G31_RS03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G31_RS03640	COG4215	(ABC) transporter
I6G31_RS03645	COG4160	amino acid transport
I6G31_RS03650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G31_RS03665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G31_RS03670	COG0432	Pfam Uncharacterised protein family UPF0047
I6G31_RS03675	COG0671	phosphoesterase, PA-phosphatase related
I6G31_RS03680	COG0814	amino acid
I6G31_RS03685	COG1760	l-serine dehydratase
I6G31_RS03690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G31_RS03695	COG1686	Belongs to the peptidase S11 family
I6G31_RS03700	COG0625	glutathione transferase activity
I6G31_RS03705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G31_RS03710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G31_RS03715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G31_RS03720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G31_RS03725	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G31_RS03725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G31_RS03730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G31_RS03735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G31_RS03740	COG0107	imidazoleglycerol-phosphate synthase activity
I6G31_RS03745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G31_RS03745	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G31_RS03750	COG1454	alcohol dehydrogenase
I6G31_RS03755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G31_RS03760	COG1301	dicarboxylic acid transport
I6G31_RS03770	COG3188	usher protein
I6G31_RS03780	COG3121	Chaperone
I6G31_RS03795	COG3121	Chaperone
I6G31_RS03815	COG1253	flavin adenine dinucleotide binding
I6G31_RS03820	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G31_RS03825	COG2982	Protein involved in outer membrane biogenesis
I6G31_RS03830	COG0717	Belongs to the dCTP deaminase family
I6G31_RS03835	COG0572	uridine kinase
I6G31_RS03840	COG0489	protein tyrosine kinase activity
I6G31_RS03845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G31_RS03845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G31_RS03850	COG1380	Effector of murein hydrolase LrgA
I6G31_RS03855	COG1346	cytolysis
I6G31_RS03860	COG0295	cytidine deaminase activity
I6G31_RS03865	COG0281	malic enzyme
I6G31_RS03870	COG2949	membrane
I6G31_RS03875	COG2311	Membrane
I6G31_RS03880	COG0302	gtp cyclohydrolase
I6G31_RS03885	COG0477	Major facilitator Superfamily
I6G31_RS03890	COG0303	'Molybdopterin
I6G31_RS03895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G31_RS03915	COG5006	permease, DMT superfamily
I6G31_RS03930	COG0583	DNA-binding transcription factor activity
I6G31_RS03935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G31_RS03955	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G31_RS03965	COG2897	thiosulfate sulfurtransferase activity
I6G31_RS03970	COG2261	transglycosylase associated protein
I6G31_RS03975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G31_RS03980	COG0513	Belongs to the DEAD box helicase family
I6G31_RS03985	COG1309	transcriptional regulator
I6G31_RS03995	COG1131	(ABC) transporter
I6G31_RS04000	COG0842	Transport permease protein
I6G31_RS04005	COG0842	Transport permease protein
I6G31_RS04010	COG0670	Belongs to the BI1 family
I6G31_RS04015	COG0314	molybdopterin synthase activity
I6G31_RS04020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G31_RS04025	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G31_RS04030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G31_RS04045	COG0556	nucleotide-excision repair
I6G31_RS04055	COG2226	methyltransferase
I6G31_RS04060	COG0156	8-amino-7-oxononanoate synthase activity
I6G31_RS04065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G31_RS04070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G31_RS04075	COG2706	6-phosphogluconolactonase activity
I6G31_RS04080	COG0561	phosphatase activity
I6G31_RS04085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6G31_RS04090	COG4149	molybdate abc transporter
I6G31_RS04095	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G31_RS04105	COG2005	Transcriptional regulator
I6G31_RS04105	COG3585	molybdate ion transport
I6G31_RS04170	COG2831	hemolysin activation secretion protein
I6G31_RS04180	COG0588	phosphoglycerate mutase activity
I6G31_RS04185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G31_RS04210	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G31_RS04215	COG2885	chlorophyll binding
I6G31_RS04220	COG0823	Involved in the tonB-independent uptake of proteins
I6G31_RS04225	COG3064	Membrane
I6G31_RS04230	COG0848	biopolymer transport protein
I6G31_RS04235	COG0811	peptide transport
I6G31_RS04240	COG0824	Thioesterase
I6G31_RS04250	COG2814	Major facilitator Superfamily
I6G31_RS04255	COG0583	DNA-binding transcription factor activity
I6G31_RS04260	COG3790	cyd operon protein YbgE
I6G31_RS04270	COG1294	oxidase, subunit
I6G31_RS04275	COG1271	oxidase subunit
I6G31_RS04280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G31_RS04285	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G31_RS04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G31_RS04295	COG0567	Dehydrogenase, E1 component
I6G31_RS04310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G31_RS04330	COG2814	Major facilitator Superfamily
I6G31_RS04340	COG0714	Associated with various cellular activities
I6G31_RS04345	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6G31_RS04350	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6G31_RS04360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G31_RS04370	COG4807	Protein conserved in bacteria
I6G31_RS04375	COG0033	Phosphoglucomutase
I6G31_RS04380	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G31_RS04385	COG0596	Alpha beta hydrolase
I6G31_RS04395	COG0716	FMN binding
I6G31_RS04400	COG0735	belongs to the Fur family
I6G31_RS04405	COG3739	integral membrane protein
I6G31_RS04415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G31_RS04420	COG1263	PTS System
I6G31_RS04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G31_RS04420	COG2190	(PTS) system
I6G31_RS04425	COG0363	glucosamine-6-phosphate deaminase activity
I6G31_RS04430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G31_RS04435	COG1940	carbohydrate kinase activity
I6G31_RS04435	COG1846	Transcriptional regulator
I6G31_RS04485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G31_RS04490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G31_RS04495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G31_RS04500	COG1702	phosphate starvation-inducible protein PhoH
I6G31_RS04505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G31_RS04515	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G31_RS04520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G31_RS04540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G31_RS04545	COG0765	amino acid transport
I6G31_RS04550	COG0765	amino acid transport
I6G31_RS04555	COG1126	abc transporter atp-binding protein
I6G31_RS04560	COG0495	leucyl-tRNA aminoacylation
I6G31_RS04565	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6G31_RS04570	COG1466	dna polymerase III delta subunit
I6G31_RS04575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G31_RS04585	COG0799	negative regulation of ribosome biogenesis
I6G31_RS04590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G31_RS04595	COG0768	penicillin binding
I6G31_RS04600	COG0772	Belongs to the SEDS family
I6G31_RS04605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G31_RS04610	COG1686	Belongs to the peptidase S11 family
I6G31_RS04620	COG0321	lipoyl(octanoyl) transferase activity
I6G31_RS04625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G31_RS04630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G31_RS04640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G31_RS04650	COG1780	Probably involved in ribonucleotide reductase function
I6G31_RS04655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G31_RS04665	COG4175	Glycine betaine
I6G31_RS04670	COG4176	ABC-type proline glycine betaine transport system permease component
I6G31_RS04675	COG2113	Glycine betaine
I6G31_RS04685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G31_RS04690	COG2267	carboxylic ester hydrolase activity
I6G31_RS04695	COG0671	phosphoesterase, PA-phosphatase related
I6G31_RS04695	COG2453	phosphatase
I6G31_RS04705	COG2814	Major facilitator Superfamily
I6G31_RS04710	COG1846	Transcriptional regulator
I6G31_RS04715	COG1566	PFAM secretion protein HlyD family protein
I6G31_RS04720	COG2814	Major facilitator Superfamily
I6G31_RS04725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G31_RS04735	COG3148	PFAM DTW domain containing protein
I6G31_RS04740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G31_RS04740	COG1042	CoA-binding domain protein
I6G31_RS04740	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G31_RS04745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G31_RS04750	COG5544	Lipoprotein
I6G31_RS04780	COG0542	response to heat
I6G31_RS04790	COG0564	pseudouridine synthase activity
I6G31_RS04795	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G31_RS04800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G31_RS04805	COG0077	Prephenate dehydratase
I6G31_RS04805	COG1605	Chorismate mutase
I6G31_RS04810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G31_RS04815	COG1605	Chorismate mutase
I6G31_RS04815	COG0287	Prephenate dehydrogenase
I6G31_RS04820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G31_RS04825	COG0335	large ribosomal subunit rRNA binding
I6G31_RS04830	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G31_RS04840	COG0228	four-way junction DNA binding
I6G31_RS04845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G31_RS04850	COG4137	Cytochrome C assembly protein
I6G31_RS04855	COG4536	flavin adenine dinucleotide binding
I6G31_RS04860	COG1854	S-ribosylhomocysteine lyase activity
I6G31_RS04865	COG2918	glutathione biosynthetic process
I6G31_RS04895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G31_RS04900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G31_RS04905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G31_RS04910	COG1546	Belongs to the CinA family
I6G31_RS04915	COG2814	Major facilitator Superfamily
I6G31_RS04920	COG0204	Acyl-transferase
I6G31_RS04920	COG0318	PFAM AMP-dependent synthetase and ligase
I6G31_RS04925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G31_RS04930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G31_RS04935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G31_RS04945	COG1073	alpha beta
I6G31_RS04950	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G31_RS04955	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G31_RS04960	COG4774	siderophore transport
I6G31_RS04965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G31_RS04975	COG3237	CsbD-like
I6G31_RS04980	COG2991	Protein conserved in bacteria
I6G31_RS04985	COG1477	protein flavinylation
I6G31_RS04990	COG2871	sodium ion transport
I6G31_RS04995	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G31_RS05000	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G31_RS05005	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G31_RS05010	COG1805	sodium ion transport
I6G31_RS05015	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G31_RS05020	COG3034	peptidoglycan biosynthetic process
I6G31_RS05025	COG0121	glutamine amidotransferase
I6G31_RS05030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G31_RS05035	COG1960	acyl-CoA dehydrogenase activity
I6G31_RS05045	COG0583	DNA-binding transcription factor activity
I6G31_RS05050	COG0583	DNA-binding transcription factor activity
I6G31_RS05070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G31_RS05075	COG0189	ligase activity
I6G31_RS05080	COG1678	Uncharacterized ACR, COG1678
I6G31_RS05085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G31_RS05090	COG2805	Type II/IV secretion system protein
I6G31_RS05095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G31_RS05100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G31_RS05105	COG0762	integral membrane protein
I6G31_RS05110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G31_RS05115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G31_RS05120	COG4607	ABC-type enterochelin transport system periplasmic component
I6G31_RS05130	COG2066	Belongs to the glutaminase family
I6G31_RS05135	COG3171	Protein conserved in bacteria
I6G31_RS05150	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G31_RS05155	COG0741	lytic transglycosylase activity
I6G31_RS05175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G31_RS05180	COG2207	Transcriptional regulator
I6G31_RS05185	COG0402	S-adenosylhomocysteine deaminase activity
I6G31_RS05280	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6G31_RS05295	COG3539	Fimbrial protein
I6G31_RS05315	COG3188	usher protein
I6G31_RS05325	COG3539	Fimbrial protein
I6G31_RS05330	COG0582	viral genome integration into host DNA
I6G31_RS05335	COG1690	Belongs to the RtcB family
I6G31_RS05345	COG4650	regulator
I6G31_RS05350	COG1234	tRNA 3'-trailer cleavage
I6G31_RS05365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G31_RS05370	COG1846	Transcriptional regulator
I6G31_RS05390	COG0126	phosphoglycerate kinase activity
I6G31_RS05395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G31_RS05400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G31_RS05420	COG0328	RNA-DNA hybrid ribonuclease activity
I6G31_RS05425	COG2226	methyltransferase
I6G31_RS05430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G31_RS05435	COG0741	lytic transglycosylase activity
I6G31_RS05435	COG1388	LysM domain
I6G31_RS05440	COG0471	metal ion transport
I6G31_RS05445	COG0148	phosphopyruvate hydratase activity
I6G31_RS05450	COG0504	CTP synthase activity
I6G31_RS05455	COG3956	TIGRFAM MazG family protein
I6G31_RS05470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G31_RS05475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G31_RS05485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G31_RS05495	COG0316	Belongs to the HesB IscA family
I6G31_RS05500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G31_RS05505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G31_RS05510	COG1643	Atp-dependent helicase
I6G31_RS05515	COG1489	DNA binding
I6G31_RS05525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G31_RS05530	COG0617	tRNA 3'-terminal CCA addition
I6G31_RS05535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G31_RS05540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G31_RS05545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G31_RS05550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6G31_RS05570	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G31_RS05580	COG3842	ATPase activity
I6G31_RS05595	COG3048	D-serine ammonia-lyase activity
I6G31_RS05600	COG2610	gluconate transmembrane transporter activity
I6G31_RS05605	COG0583	DNA-binding transcription factor activity
I6G31_RS05610	COG0754	glutathionylspermidine amidase activity
I6G31_RS05625	COG4633	Protein conserved in bacteria
I6G31_RS05640	COG2837	iron assimilation
I6G31_RS05650	COG0243	molybdopterin cofactor binding
I6G31_RS05655	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS05680	COG0477	Major facilitator Superfamily
I6G31_RS05685	COG0842	Transport permease protein
I6G31_RS05690	COG1131	(ABC) transporter
I6G31_RS05695	COG0288	reversible hydration of carbon dioxide
I6G31_RS05700	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G31_RS05705	COG2132	Multicopper oxidase
I6G31_RS05720	COG1846	Transcriptional regulator
I6G31_RS05720	COG0456	acetyltransferase
I6G31_RS05750	COG5441	Belongs to the UPF0261 family
I6G31_RS05755	COG5564	TIM-barrel signal transduction protein
I6G31_RS05760	COG0673	inositol 2-dehydrogenase activity
I6G31_RS05775	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G31_RS05780	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G31_RS05790	COG0523	cobalamin synthesis protein
I6G31_RS05795	COG2879	small protein
I6G31_RS05800	COG1966	Carbon starvation protein
I6G31_RS05820	COG4245	von Willebrand factor, type A
I6G31_RS05825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G31_RS05830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G31_RS05840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G31_RS05855	COG3264	Mechanosensitive ion channel
I6G31_RS05855	COG1196	nuclear chromosome segregation
I6G31_RS05860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G31_RS05865	COG1309	transcriptional regulator
I6G31_RS05870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G31_RS05875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G31_RS05895	COG1946	Acyl-CoA thioesterase
I6G31_RS05900	COG0004	ammonium transporteR
I6G31_RS05905	COG0347	Belongs to the P(II) protein family
I6G31_RS05910	COG1132	(ABC) transporter
I6G31_RS05915	COG1132	(ABC) transporter
I6G31_RS05920	COG1522	sequence-specific DNA binding
I6G31_RS05925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G31_RS05930	COG0824	Thioesterase
I6G31_RS05935	COG1555	photosystem II stabilization
I6G31_RS05935	COG1596	polysaccharide export
I6G31_RS05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G31_RS05945	COG0776	regulation of translation
I6G31_RS05950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G31_RS05955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G31_RS05960	COG0740	serine-type endopeptidase activity
I6G31_RS05965	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G31_RS05970	COG0271	Belongs to the BolA IbaG family
I6G31_RS05975	COG3056	Lipoprotein
I6G31_RS05980	COG2223	nitrite transmembrane transporter activity
I6G31_RS05985	COG0513	Belongs to the DEAD box helicase family
I6G31_RS05995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G31_RS06000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G31_RS06005	COG1845	cytochrome c oxidase, subunit III
I6G31_RS06010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G31_RS06015	COG0109	protoheme IX farnesyltransferase activity
I6G31_RS06020	COG2814	Major facilitator Superfamily
I6G31_RS06025	COG1666	GTP binding
I6G31_RS06030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G31_RS06035	COG0693	protein deglycase activity
I6G31_RS06040	COG0301	tRNA thio-modification
I6G31_RS06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G31_RS06045	COG1722	exodeoxyribonuclease VII activity
I6G31_RS06050	COG0142	geranyltranstransferase activity
I6G31_RS06055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G31_RS06060	COG1869	D-ribose catabolic process
I6G31_RS06065	COG1129	ABC transporter
I6G31_RS06070	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G31_RS06075	COG1879	ABC-type sugar transport system periplasmic component
I6G31_RS06080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G31_RS06085	COG1609	Transcriptional regulator
I6G31_RS06090	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G31_RS06095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G31_RS06100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G31_RS06105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G31_RS06110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G31_RS06110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G31_RS06115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G31_RS06120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G31_RS06125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G31_RS06130	COG1862	Preprotein translocase
I6G31_RS06135	COG0343	queuine tRNA-ribosyltransferase activity
I6G31_RS06140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G31_RS06145	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6G31_RS06150	COG0450	alkyl hydroperoxide reductase
I6G31_RS06160	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS06165	COG2414	aldehyde ferredoxin oxidoreductase
I6G31_RS06175	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS06180	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6G31_RS06200	COG1114	Component of the transport system for branched-chain amino acids
I6G31_RS06205	COG5002	protein histidine kinase activity
I6G31_RS06215	COG0420	3'-5' exonuclease activity
I6G31_RS06220	COG0419	ATPase involved in DNA repair
I6G31_RS06245	COG3719	Belongs to the RNase T2 family
I6G31_RS06250	COG0737	Belongs to the 5'-nucleotidase family
I6G31_RS06260	COG2974	May be involved in recombination
I6G31_RS06265	COG0425	Belongs to the sulfur carrier protein TusA family
I6G31_RS06275	COG0309	Hydrogenase expression formation protein (HypE)
I6G31_RS06280	COG0409	Hydrogenase expression formation protein
I6G31_RS06285	COG0298	carbon dioxide binding
I6G31_RS06290	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G31_RS06295	COG1773	rubredoxin
I6G31_RS06300	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G31_RS06305	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G31_RS06310	COG5557	Pfam Polysulphide reductase, NrfD
I6G31_RS06315	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS06320	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G31_RS06325	COG0848	biopolymer transport protein
I6G31_RS06330	COG0811	peptide transport
I6G31_RS06335	COG0626	cystathionine gamma-synthase activity
I6G31_RS06350	COG1979	alcohol dehydrogenase
I6G31_RS06355	COG0656	L-ascorbic acid biosynthetic process
I6G31_RS06360	COG1388	LysM domain
I6G31_RS06360	COG1470	cell adhesion involved in biofilm formation
I6G31_RS06375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G31_RS06385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G31_RS06390	COG1047	Peptidyl-prolyl cis-trans
I6G31_RS06395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G31_RS06400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G31_RS06405	COG0196	riboflavin kinase activity
I6G31_RS06410	COG0268	Binds directly to 16S ribosomal RNA
I6G31_RS06415	COG0583	DNA-binding transcription factor activity
I6G31_RS06420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G31_RS06430	COG0484	heat shock protein binding
I6G31_RS06435	COG0443	Heat shock 70 kDa protein
I6G31_RS06440	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G31_RS06450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G31_RS06455	COG3022	response to hydroperoxide
I6G31_RS06470	COG0083	homoserine kinase activity
I6G31_RS06480	COG0745	RESPONSE REGULATOR receiver
I6G31_RS06485	COG3045	CreA protein
I6G31_RS06490	COG2207	Transcriptional regulator
I6G31_RS06490	COG3708	Transcriptional regulator
I6G31_RS06495	COG0406	alpha-ribazole phosphatase activity
I6G31_RS06500	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6G31_RS06505	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6G31_RS06510	COG0741	lytic transglycosylase activity
I6G31_RS06515	COG0488	(ABC) transporter
I6G31_RS06535	COG4771	TonB-dependent receptor
I6G31_RS06540	COG4178	(ABC) transporter
I6G31_RS06555	COG1902	pentaerythritol trinitrate reductase activity
I6G31_RS06555	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G31_RS06560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G31_RS06565	COG0586	Pfam SNARE associated Golgi protein
I6G31_RS06570	COG4575	ribosome binding
I6G31_RS06575	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6G31_RS06585	COG2259	Doxx family
I6G31_RS06590	COG0583	DNA-binding transcription factor activity
I6G31_RS06595	COG1741	Belongs to the pirin family
I6G31_RS06605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G31_RS06615	COG0792	nuclease activity
I6G31_RS06620	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G31_RS06625	COG2823	Periplasmic or secreted lipoprotein
I6G31_RS06630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G31_RS06635	COG0830	nickel cation binding
I6G31_RS06640	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6G31_RS06650	COG0832	Belongs to the urease beta subunit family
I6G31_RS06665	COG2207	Transcriptional regulator
I6G31_RS06670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G31_RS06675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G31_RS06680	COG5002	protein histidine kinase activity
I6G31_RS06680	COG0784	Response regulator, receiver
I6G31_RS06680	COG2198	Histidine kinase
I6G31_RS06685	COG0069	glutamate synthase activity
I6G31_RS06685	COG0070	glutamate synthase
I6G31_RS06685	COG0067	glutamate synthase
I6G31_RS06690	COG0493	'glutamate synthase
I6G31_RS06695	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G31_RS06700	COG1473	amidohydrolase
I6G31_RS06705	COG2969	positive regulation of protein catabolic process
I6G31_RS06710	COG0625	glutathione transferase activity
I6G31_RS06715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G31_RS06720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G31_RS06730	COG3105	Protein conserved in bacteria
I6G31_RS06735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G31_RS06755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G31_RS06760	COG5007	Belongs to the BolA IbaG family
I6G31_RS06770	COG2854	intermembrane phospholipid transfer
I6G31_RS06775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G31_RS06780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G31_RS06785	COG1127	ABC transporter
I6G31_RS06790	COG0530	calcium, potassium:sodium antiporter activity
I6G31_RS06795	COG0517	IMP dehydrogenase activity
I6G31_RS06795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G31_RS06800	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G31_RS06805	COG3117	lipopolysaccharide transmembrane transporter activity
I6G31_RS06810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G31_RS06815	COG1137	ATPase activity
I6G31_RS06820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G31_RS06825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G31_RS06835	COG1660	Displays ATPase and GTPase activities
I6G31_RS06840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G31_RS06845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G31_RS06850	COG0312	modulator of DNA gyrase
I6G31_RS06855	COG3028	Belongs to the UPF0307 family
I6G31_RS06865	COG4290	ribonuclease
I6G31_RS06870	COG0312	modulator of DNA gyrase
I6G31_RS06875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G31_RS06885	COG1530	ribonuclease E activity
I6G31_RS06895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G31_RS06900	COG1792	Involved in formation and maintenance of cell shape
I6G31_RS06905	COG1077	Cell shape determining protein MreB Mrl
I6G31_RS06910	COG0604	alcohol dehydrogenase
I6G31_RS06915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G31_RS06920	COG0511	ligase activity, forming carbon-carbon bonds
I6G31_RS06925	COG0439	Biotin carboxylase
I6G31_RS06930	COG3924	membrane
I6G31_RS06935	COG4145	pantothenate transmembrane transporter activity
I6G31_RS06940	COG2264	protein methyltransferase activity
I6G31_RS06945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G31_RS06950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6G31_RS06975	COG2807	transmembrane transport
I6G31_RS06980	COG0549	Belongs to the carbamate kinase family
I6G31_RS06985	COG0584	glycerophosphoryl diester phosphodiesterase
I6G31_RS06990	COG1653	transport
I6G31_RS06995	COG1175	transmembrane transport
I6G31_RS07000	COG0395	ABC-type sugar transport system, permease component
I6G31_RS07005	COG3842	ATPase activity
I6G31_RS07010	COG0501	Belongs to the peptidase M48B family
I6G31_RS07015	COG1846	Transcriptional regulator
I6G31_RS07020	COG2814	Major facilitator Superfamily
I6G31_RS07025	COG0456	acetyltransferase
I6G31_RS07030	COG1929	Belongs to the glycerate kinase type-1 family
I6G31_RS07040	COG2177	Part of the ABC transporter FtsEX involved in
I6G31_RS07045	COG2884	Cell division ATP-binding protein ftsE
I6G31_RS07050	COG0552	protein localization to endoplasmic reticulum
I6G31_RS07055	COG0742	ribosomal rna small subunit methyltransferase
I6G31_RS07060	COG3776	membrane
I6G31_RS07070	COG3714	YhhN family
I6G31_RS07075	COG2217	Heavy metal translocating P-type atpase
I6G31_RS07080	COG0425	Belongs to the sulfur carrier protein TusA family
I6G31_RS07085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G31_RS07100	COG0247	lactate metabolic process
I6G31_RS07115	COG2271	Major facilitator Superfamily
I6G31_RS07120	COG0584	glycerophosphoryl diester phosphodiesterase
I6G31_RS07145	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6G31_RS07150	COG1053	succinate dehydrogenase
I6G31_RS07155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G31_RS07160	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G31_RS07165	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G31_RS07170	COG2076	Multidrug Resistance protein
I6G31_RS07175	COG0298	carbon dioxide binding
I6G31_RS07180	COG0375	protein maturation
I6G31_RS07185	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G31_RS07190	COG3604	Transcriptional regulator
I6G31_RS07205	COG2194	sulfuric ester hydrolase activity
I6G31_RS07210	COG1304	FMN binding
I6G31_RS07215	COG1335	isochorismatase
I6G31_RS07220	COG2181	nitrate reductase activity
I6G31_RS07225	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G31_RS07230	COG1140	nitrate reductase beta subunit
I6G31_RS07235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G31_RS07240	COG2223	nitrite transmembrane transporter activity
I6G31_RS07245	COG3850	Histidine kinase
I6G31_RS07250	COG2197	response regulator
I6G31_RS07255	COG0583	DNA-binding transcription factor activity
I6G31_RS07270	COG0730	response to heat
I6G31_RS07275	COG4770	biotin carboxylase activity
I6G31_RS07280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G31_RS07285	COG4336	lyase activity
I6G31_RS07290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G31_RS07295	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G31_RS07330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G31_RS07335	COG1739	Uncharacterized protein family UPF0029
I6G31_RS07340	COG0006	proline dipeptidase activity
I6G31_RS07345	COG1024	Enoyl-CoA hydratase
I6G31_RS07345	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G31_RS07350	COG0183	Belongs to the thiolase family
I6G31_RS07360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G31_RS07375	COG0805	protein transport
I6G31_RS07380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G31_RS07385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G31_RS07395	COG3165	ubiquinone biosynthetic process from chorismate
I6G31_RS07400	COG2226	methyltransferase
I6G31_RS07405	COG1322	Protein conserved in bacteria
I6G31_RS07410	COG0586	Pfam SNARE associated Golgi protein
I6G31_RS07425	COG3753	Protein conserved in bacteria
I6G31_RS07435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G31_RS07440	COG0583	DNA-binding transcription factor activity
I6G31_RS07450	COG0025	NhaP-type Na H and K H
I6G31_RS07455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G31_RS07460	COG2252	PERMEase
I6G31_RS07480	COG0440	acetolactate synthase activity
I6G31_RS07485	COG0028	Belongs to the TPP enzyme family
I6G31_RS07495	COG1288	antiporter activity
I6G31_RS07500	COG0549	Belongs to the carbamate kinase family
I6G31_RS07505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G31_RS07525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G31_RS07525	COG1263	PTS System
I6G31_RS07530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G31_RS07540	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G31_RS07545	COG1349	DNA-binding transcription factor activity
I6G31_RS07555	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G31_RS07560	COG2271	Major facilitator Superfamily
I6G31_RS07565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G31_RS07575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G31_RS07580	COG3829	transcription factor binding
I6G31_RS07605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G31_RS07610	COG3811	Belongs to the UPF0386 family
I6G31_RS07615	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G31_RS07645	COG0438	transferase activity, transferring glycosyl groups
I6G31_RS07665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G31_RS07670	COG0795	lipopolysaccharide-transporting ATPase activity
I6G31_RS07675	COG0795	lipopolysaccharide-transporting ATPase activity
I6G31_RS07680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G31_RS07685	COG2927	DNA polymerase III (CHI subunit)
I6G31_RS07690	COG0525	valine-tRNA ligase activity
I6G31_RS07695	COG0456	acetyltransferase
I6G31_RS07710	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6G31_RS07715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G31_RS07725	COG0540	Belongs to the ATCase OTCase family
I6G31_RS07730	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6G31_RS07735	COG0251	oxidation-reduction process
I6G31_RS07740	COG1328	CTP reductase activity
I6G31_RS07745	COG0602	queuosine metabolic process
I6G31_RS07775	COG0633	Ferredoxin
I6G31_RS07800	COG2827	Endonuclease containing a URI domain
I6G31_RS07805	COG3153	acetyltransferase
I6G31_RS07810	COG3154	lipid carrier protein
I6G31_RS07815	COG0826	peptidase U32
I6G31_RS07820	COG0826	peptidase U32
I6G31_RS07835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G31_RS07840	COG3275	phosphorelay sensor kinase activity
I6G31_RS07850	COG0513	Belongs to the DEAD box helicase family
I6G31_RS07860	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G31_RS07865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G31_RS07870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G31_RS07875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G31_RS07880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G31_RS07885	COG0195	Participates in both transcription termination and antitermination
I6G31_RS07890	COG0779	Required for maturation of 30S ribosomal subunits
I6G31_RS07905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G31_RS07910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G31_RS07915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G31_RS07920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G31_RS07925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G31_RS07930	COG1534	Rna-binding protein
I6G31_RS07940	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G31_RS07945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G31_RS07950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G31_RS07955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G31_RS07960	COG0142	geranyltranstransferase activity
I6G31_RS07975	COG3423	Transcriptional regulator
I6G31_RS07980	COG0039	L-malate dehydrogenase activity
I6G31_RS07985	COG1438	arginine binding
I6G31_RS07990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G31_RS07995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G31_RS08000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G31_RS08020	COG2105	PFAM AIG2 family protein
I6G31_RS08025	COG2911	Protein conserved in bacteria
I6G31_RS08030	COG0729	surface antigen
I6G31_RS08035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G31_RS08040	COG1253	flavin adenine dinucleotide binding
I6G31_RS08050	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G31_RS08060	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G31_RS08065	COG1012	belongs to the aldehyde dehydrogenase family
I6G31_RS08070	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G31_RS08075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G31_RS08080	COG0254	rRNA binding
I6G31_RS08095	COG0359	binds to the 23S rRNA
I6G31_RS08100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G31_RS08105	COG2965	DNA replication, synthesis of RNA primer
I6G31_RS08110	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G31_RS08115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G31_RS08120	COG0557	exoribonuclease II activity
I6G31_RS08125	COG1959	2 iron, 2 sulfur cluster binding
I6G31_RS08130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G31_RS08140	COG0330	HflC and HflK could
I6G31_RS08145	COG0330	HflC and HflK could
I6G31_RS08150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G31_RS08155	COG1923	regulation of RNA biosynthetic process
I6G31_RS08160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G31_RS08165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G31_RS08170	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G31_RS08175	COG0802	atpase or kinase
I6G31_RS08180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G31_RS08195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G31_RS08200	COG1162	GTPase activity
I6G31_RS08205	COG0688	phosphatidylethanolamine metabolic process
I6G31_RS08210	COG1511	domain protein
I6G31_RS08210	COG3264	Mechanosensitive ion channel
I6G31_RS08220	COG3539	Fimbrial protein
I6G31_RS08230	COG3188	usher protein
I6G31_RS08240	COG0561	phosphatase activity
I6G31_RS08245	COG2267	carboxylic ester hydrolase activity
I6G31_RS08260	COG2050	protein possibly involved in aromatic compounds catabolism
I6G31_RS08265	COG2962	Rard protein
I6G31_RS08275	COG0210	DNA helicase
I6G31_RS08280	COG1011	Hydrolase
I6G31_RS08295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G31_RS08305	COG1965	Belongs to the frataxin family
I6G31_RS08315	COG0181	hydroxymethylbilane synthase activity
I6G31_RS08325	COG2959	enzyme of heme biosynthesis
I6G31_RS08330	COG3071	HemY protein
I6G31_RS08360	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6G31_RS08370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G31_RS08375	COG2244	polysaccharide biosynthetic process
I6G31_RS08380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G31_RS08385	COG0456	acetyltransferase
I6G31_RS08390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G31_RS08395	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G31_RS08400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G31_RS08405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G31_RS08415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G31_RS08420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G31_RS08425	COG3118	belongs to the thioredoxin family
I6G31_RS08430	COG0513	Belongs to the DEAD box helicase family
I6G31_RS08435	COG0248	Ppx GppA phosphatase
I6G31_RS08450	COG3041	Addiction module toxin RelE StbE family
I6G31_RS08455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G31_RS08470	COG0129	dihydroxy-acid dehydratase activity
I6G31_RS08480	COG3978	acetolactate synthase activity
I6G31_RS08495	COG0606	chelatase, subunit chli
I6G31_RS08500	COG3085	chromosome segregation
I6G31_RS08505	COG0583	DNA-binding transcription factor activity
I6G31_RS08540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G31_RS08550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G31_RS08555	COG0009	L-threonylcarbamoyladenylate synthase
I6G31_RS08560	COG0551	DNA topoisomerase type I activity
I6G31_RS08565	COG0758	DNA mediated transformation
I6G31_RS08570	COG0242	peptide deformylase activity
I6G31_RS08575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G31_RS08580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G31_RS08580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G31_RS08585	COG0569	domain protein
I6G31_RS08590	COG1970	mechanosensitive ion channel activity
I6G31_RS08595	COG3036	rescue of stalled ribosome
I6G31_RS08600	COG0789	Transcriptional regulator
I6G31_RS08605	COG0203	ribosomal protein L17
I6G31_RS08615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G31_RS08625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G31_RS08630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G31_RS08635	COG0201	protein transport
I6G31_RS08640	COG0200	Binds to the 23S rRNA
I6G31_RS08645	COG1841	ribosomal large subunit assembly
I6G31_RS08650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G31_RS08655	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G31_RS08660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G31_RS08665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G31_RS08670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G31_RS08675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G31_RS08680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G31_RS08685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G31_RS08690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G31_RS08695	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G31_RS08700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G31_RS08710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G31_RS08715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G31_RS08720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G31_RS08725	COG0089	rRNA binding
I6G31_RS08730	COG0088	Forms part of the polypeptide exit tunnel
I6G31_RS08735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G31_RS08740	COG0051	transcription antitermination factor activity, RNA binding
I6G31_RS08880	COG3036	rescue of stalled ribosome
I6G31_RS08915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G31_RS08950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G31_RS08965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G31_RS08970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G31_RS08975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G31_RS08980	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G31_RS08985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G31_RS08995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G31_RS09000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G31_RS09005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G31_RS09010	COG0089	rRNA binding
I6G31_RS09015	COG0088	Forms part of the polypeptide exit tunnel
I6G31_RS09020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G31_RS09025	COG0051	transcription antitermination factor activity, RNA binding
I6G31_RS09065	COG1072	(Pantothenic acid kinase))
I6G31_RS09110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G31_RS09115	COG4206	TonB-dependent receptor
I6G31_RS09120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G31_RS09135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G31_RS09145	COG0165	Argininosuccinate lyase
I6G31_RS09150	COG0137	argininosuccinate synthase activity
I6G31_RS09155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G31_RS09160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G31_RS09165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G31_RS09170	COG0028	Belongs to the TPP enzyme family
I6G31_RS09190	COG0583	DNA-binding transcription factor activity
I6G31_RS09205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G31_RS09210	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6G31_RS09220	COG2862	Uncharacterized protein family, UPF0114
I6G31_RS09225	COG0460	homoserine dehydrogenase
I6G31_RS09225	COG0527	aspartate kinase activity
I6G31_RS09230	COG0626	cystathionine gamma-synthase activity
I6G31_RS09235	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6G31_RS09240	COG0254	rRNA binding
I6G31_RS09245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G31_RS09250	COG1609	Transcriptional regulator
I6G31_RS09255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G31_RS09260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G31_RS09265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G31_RS09270	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G31_RS09275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G31_RS09280	COG3074	FtsZ-dependent cytokinesis
I6G31_RS09290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G31_RS09295	COG2814	Major facilitator Superfamily
I6G31_RS09300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G31_RS09305	COG3152	Membrane
I6G31_RS09315	COG0149	triose-phosphate isomerase activity
I6G31_RS09320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G31_RS09325	COG0205	6-phosphofructokinase activity
I6G31_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
I6G31_RS09350	COG3678	ATP-independent chaperone mediated protein folding
I6G31_RS09355	COG0745	RESPONSE REGULATOR receiver
I6G31_RS09360	COG2205	protein histidine kinase activity
I6G31_RS09380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G31_RS09385	COG1045	serine acetyltransferase
I6G31_RS09390	COG1045	serine acetyltransferase
I6G31_RS09400	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6G31_RS09405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G31_RS09410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G31_RS09415	COG4942	peptidase
I6G31_RS09420	COG2861	carbohydrate metabolic process
I6G31_RS09425	COG1063	alcohol dehydrogenase
I6G31_RS09435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G31_RS09445	COG0859	PFAM glycosyl transferase family 9
I6G31_RS09450	COG0859	PFAM glycosyl transferase family 9
I6G31_RS09460	COG0859	PFAM glycosyl transferase family 9
I6G31_RS09465	COG0438	transferase activity, transferring glycosyl groups
I6G31_RS09470	COG0438	transferase activity, transferring glycosyl groups
I6G31_RS09475	COG1519	Transferase
I6G31_RS09485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G31_RS09490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G31_RS09515	COG0438	transferase activity, transferring glycosyl groups
I6G31_RS09520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G31_RS09525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G31_RS09530	COG2003	Belongs to the UPF0758 family
I6G31_RS09535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G31_RS09540	COG0756	dUTP diphosphatase activity
I6G31_RS09545	COG1309	transcriptional regulator
I6G31_RS09550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G31_RS09555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G31_RS09560	COG1561	YicC-like family, N-terminal region
I6G31_RS09570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G31_RS09595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G31_RS09600	COG0187	DNA topoisomerase II activity
I6G31_RS09605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G31_RS09615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G31_RS09620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G31_RS09625	COG0594	ribonuclease P activity
I6G31_RS09630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G31_RS09635	COG0706	membrane insertase activity
I6G31_RS09640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G31_RS09645	COG1396	sequence-specific DNA binding
I6G31_RS09650	COG3550	peptidyl-serine autophosphorylation
I6G31_RS09690	COG0583	DNA-binding transcription factor activity
I6G31_RS09710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G31_RS09720	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS09725	COG2864	formate dehydrogenase
I6G31_RS09730	COG3058	Necessary for formate dehydrogenase activity
I6G31_RS09740	COG3276	selenocysteine insertion sequence binding
I6G31_RS09745	COG1368	sulfuric ester hydrolase activity
I6G31_RS09770	COG1584	GPR1 FUN34 yaaH family protein
I6G31_RS09775	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G31_RS09785	COG1288	antiporter activity
I6G31_RS09795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G31_RS09805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G31_RS09810	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G31_RS09815	COG1178	ABC-type Fe3 transport system permease component
I6G31_RS09820	COG3842	ATPase activity
I6G31_RS09830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G31_RS09835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G31_RS09840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G31_RS09845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G31_RS09850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G31_RS09855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G31_RS09860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G31_RS09865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G31_RS09875	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G31_RS09880	COG3312	ion transport
I6G31_RS09885	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G31_RS09890	COG0445	tRNA wobble uridine modification
I6G31_RS09895	COG0716	FMN binding
I6G31_RS09900	COG1522	sequence-specific DNA binding
I6G31_RS09905	COG2502	aspartate--ammonia ligase
I6G31_RS09910	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6G31_RS09915	COG0714	Associated with various cellular activities
I6G31_RS09920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G31_RS09925	COG0477	Major facilitator Superfamily
I6G31_RS09930	COG2186	Transcriptional regulator
I6G31_RS09960	COG0247	lactate metabolic process
I6G31_RS09965	COG1139	Iron-sulfur cluster binding protein
I6G31_RS09970	COG1556	Lactate utilization protein
I6G31_RS09975	COG2194	sulfuric ester hydrolase activity
I6G31_RS09980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G31_RS09985	COG3162	membrane
I6G31_RS09990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G31_RS09995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G31_RS10000	COG2258	MOSC domain
I6G31_RS10005	COG0180	Tryptophanyl-tRNA synthetase
I6G31_RS10010	COG0546	phosphoglycolate phosphatase activity
I6G31_RS10015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G31_RS10030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G31_RS10035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G31_RS10040	COG4796	Type ii and iii secretion system protein
I6G31_RS10060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G31_RS10065	COG0494	nUDIX hydrolase
I6G31_RS10075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G31_RS10080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G31_RS10085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6G31_RS10090	COG1741	Belongs to the pirin family
I6G31_RS10095	COG2081	HI0933 family
I6G31_RS10100	COG0306	phosphate transporter
I6G31_RS10110	COG0589	response to stress
I6G31_RS10120	COG1028	Short-chain dehydrogenase reductase Sdr
I6G31_RS10125	COG0742	ribosomal rna small subunit methyltransferase
I6G31_RS10140	COG3210	domain, Protein
I6G31_RS10190	COG2831	hemolysin activation secretion protein
I6G31_RS10195	COG1403	HNH endonuclease
I6G31_RS10200	COG3122	Protein conserved in bacteria
I6G31_RS10210	COG0564	pseudouridine synthase activity
I6G31_RS10220	COG1737	Transcriptional regulator
I6G31_RS10225	COG1263	PTS System
I6G31_RS10225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G31_RS10230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G31_RS10255	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6G31_RS10265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G31_RS10270	COG2731	YhcH YjgK YiaL family protein
I6G31_RS10275	COG1737	Transcriptional regulator
I6G31_RS10290	COG1285	pathogenesis
I6G31_RS10295	COG2211	Major facilitator Superfamily
I6G31_RS10315	COG3302	dmso reductase anchor subunit
I6G31_RS10320	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS10325	COG0243	molybdopterin cofactor binding
I6G31_RS10335	COG0531	amino acid
I6G31_RS10345	COG0531	amino acid
I6G31_RS10360	COG4604	ABC transporter, ATP-binding protein
I6G31_RS10365	COG4605	iron ion homeostasis
I6G31_RS10370	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G31_RS10375	COG4607	ABC-type enterochelin transport system periplasmic component
I6G31_RS10380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G31_RS10385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G31_RS10390	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G31_RS10395	COG1917	Cupin 2, conserved barrel domain protein
I6G31_RS10395	COG2169	Transcriptional regulator
I6G31_RS10400	COG1486	melibiose metabolic process
I6G31_RS10405	COG3394	polysaccharide catabolic process
I6G31_RS10430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G31_RS10440	COG1136	(ABC) transporter
I6G31_RS10475	COG1073	alpha beta
I6G31_RS10475	COG2226	methyltransferase
I6G31_RS10480	COG0747	negative chemotaxis
I6G31_RS10485	COG0601	transmembrane transport
I6G31_RS10490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G31_RS10500	COG1124	(ABC) transporter
I6G31_RS10515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G31_RS10555	COG3189	MarR family transcriptional regulator
I6G31_RS10560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G31_RS10565	COG1349	DNA-binding transcription factor activity
I6G31_RS10570	COG0705	Rhomboid family
I6G31_RS10575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G31_RS10580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G31_RS10580	COG0316	Belongs to the HesB IscA family
I6G31_RS10590	COG2267	carboxylic ester hydrolase activity
I6G31_RS10605	COG1918	ferrous iron import across plasma membrane
I6G31_RS10625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G31_RS10630	COG2252	PERMEase
I6G31_RS10635	COG0765	amino acid transport
I6G31_RS10640	COG0765	amino acid transport
I6G31_RS10645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G31_RS10650	COG0704	Plays a role in the regulation of phosphate uptake
I6G31_RS10660	COG0581	inorganic phosphate transmembrane transporter activity
I6G31_RS10665	COG0573	inorganic phosphate transmembrane transporter activity
I6G31_RS10670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G31_RS10685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G31_RS10690	COG2183	response to ionizing radiation
I6G31_RS10710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G31_RS10730	COG1217	gtp-binding protein TYPA
I6G31_RS10735	COG1011	Hydrolase
I6G31_RS10745	COG0456	acetyltransferase
I6G31_RS10760	COG2982	Protein involved in outer membrane biogenesis
I6G31_RS10765	COG2233	PERMEase
I6G31_RS10770	COG0786	glutamate:sodium symporter activity
I6G31_RS10775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G31_RS10780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G31_RS10785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G31_RS10790	COG1758	RNA polymerase activity
I6G31_RS10795	COG0194	GDP metabolic process
I6G31_RS10800	COG2860	membrane
I6G31_RS10805	COG0823	Involved in the tonB-independent uptake of proteins
I6G31_RS10815	COG0751	glycine-tRNA ligase activity
I6G31_RS10820	COG0752	glycyl-tRNA synthetase alpha subunit
I6G31_RS10825	COG2818	Glycosylase
I6G31_RS10830	COG3977	Valine--pyruvate aminotransferase
I6G31_RS10835	COG0569	domain protein
I6G31_RS10835	COG2985	domain, Protein
I6G31_RS10840	COG5645	(Lipo)protein
I6G31_RS10855	COG2831	hemolysin activation secretion protein
I6G31_RS10860	COG0747	negative chemotaxis
I6G31_RS10865	COG0601	transmembrane transport
I6G31_RS10870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G31_RS10875	COG0444	Belongs to the ABC transporter superfamily
I6G31_RS10880	COG4608	Belongs to the ABC transporter superfamily
I6G31_RS10885	COG2199	diguanylate cyclase activity
I6G31_RS10885	COG2200	EAL domain
I6G31_RS10890	COG0612	Peptidase, M16
I6G31_RS10900	COG1942	4-Oxalocrotonate Tautomerase
I6G31_RS10905	COG1295	ribonuclease BN
I6G31_RS10915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G31_RS10920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G31_RS10925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G31_RS10935	COG1609	Transcriptional regulator
I6G31_RS10940	COG0366	Alpha amylase catalytic
I6G31_RS10945	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G31_RS10950	COG0746	molybdenum cofactor guanylyltransferase activity
I6G31_RS10955	COG3084	Protein conserved in bacteria
I6G31_RS10960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G31_RS10965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G31_RS10970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G31_RS10970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G31_RS10975	COG0242	peptide deformylase activity
I6G31_RS10985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G31_RS10995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G31_RS11000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G31_RS11005	COG1765	OsmC-like protein
I6G31_RS11010	COG3954	Phosphoribulokinase
I6G31_RS11015	COG3089	Belongs to the UPF0270 family
I6G31_RS11020	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G31_RS11035	COG0840	transmembrane signaling receptor activity
I6G31_RS11040	COG0840	transmembrane signaling receptor activity
I6G31_RS11045	COG0840	transmembrane signaling receptor activity
I6G31_RS11050	COG0488	(ABC) transporter
I6G31_RS11065	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G31_RS11070	COG1047	Peptidyl-prolyl cis-trans
I6G31_RS11075	COG2900	Belongs to the SlyX family
I6G31_RS11080	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G31_RS11095	COG2964	Protein conserved in bacteria
I6G31_RS11100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G31_RS11105	COG2923	Belongs to the DsrF TusC family
I6G31_RS11115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G31_RS11120	COG0049	tRNA binding
I6G31_RS11125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G31_RS11140	COG0250	Participates in transcription elongation, termination and antitermination
I6G31_RS11145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G31_RS11150	COG0081	regulation of translation
I6G31_RS11155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G31_RS11160	COG0222	ribosome binding
I6G31_RS11165	COG0085	RNA polymerase activity
I6G31_RS11170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G31_RS11175	COG0726	polysaccharide deacetylase
I6G31_RS11180	COG5464	transposase or invertase
I6G31_RS11190	COG2022	thiamine diphosphate biosynthetic process
I6G31_RS11195	COG2104	thiamine diphosphate biosynthetic process
I6G31_RS11200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G31_RS11205	COG0352	thiamine-phosphate diphosphorylase activity
I6G31_RS11210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G31_RS11220	COG2816	NAD+ diphosphatase activity
I6G31_RS11225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G31_RS11230	COG1515	deoxyribonuclease V activity
I6G31_RS11235	COG3068	Protein conserved in bacteria
I6G31_RS11255	COG0138	bifunctional purine biosynthesis protein purh
I6G31_RS11285	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G31_RS11290	COG0371	Dehydrogenase
I6G31_RS11295	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G31_RS11300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G31_RS11305	COG2224	Isocitrate lyase
I6G31_RS11315	COG0800	Aldolase
I6G31_RS11320	COG0129	dihydroxy-acid dehydratase activity
I6G31_RS11330	COG1410	methionine synthase
I6G31_RS11330	COG0646	methionine synthase
I6G31_RS11340	COG0527	aspartate kinase activity
I6G31_RS11345	COG0166	Belongs to the GPI family
I6G31_RS11350	COG3161	chorismate lyase activity
I6G31_RS11355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G31_RS11360	COG2937	Belongs to the GPAT DAPAT family
I6G31_RS11365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G31_RS11370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G31_RS11380	COG0735	belongs to the Fur family
I6G31_RS11395	COG0814	amino acid
I6G31_RS11405	COG1448	Aminotransferase
I6G31_RS11430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G31_RS11435	COG3196	Protein conserved in bacteria
I6G31_RS11455	COG1177	transmembrane transport
I6G31_RS11465	COG1396	sequence-specific DNA binding
I6G31_RS11475	COG3539	Fimbrial protein
I6G31_RS11480	COG3188	usher protein
I6G31_RS11500	COG2873	o-acetylhomoserine
I6G31_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
I6G31_RS11535	COG1454	alcohol dehydrogenase
I6G31_RS11540	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6G31_RS11550	COG1882	Formate acetyltransferase
I6G31_RS11565	COG4869	propanediol catabolic process
I6G31_RS11590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G31_RS11605	COG0789	Transcriptional regulator
I6G31_RS11645	COG2207	Transcriptional regulator
I6G31_RS11690	COG4790	Type iii secretion
I6G31_RS11730	COG4771	TonB-dependent receptor
I6G31_RS11735	COG0157	Belongs to the NadC ModD family
I6G31_RS11740	COG0500	methyltransferase
I6G31_RS11745	COG1120	ATPase activity
I6G31_RS11750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G31_RS11755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G31_RS11760	COG1609	Transcriptional regulator
I6G31_RS11765	COG3265	gluconokinase activity
I6G31_RS11770	COG2610	gluconate transmembrane transporter activity
I6G31_RS11775	COG0840	transmembrane signaling receptor activity
I6G31_RS11795	COG2992	FlgJ-related protein
I6G31_RS11815	COG2137	regulation of response to DNA damage stimulus
I6G31_RS11820	COG0583	DNA-binding transcription factor activity
I6G31_RS11865	COG3397	chitin binding
I6G31_RS11885	COG1024	Enoyl-CoA hydratase
I6G31_RS11890	COG0318	PFAM AMP-dependent synthetase and ligase
I6G31_RS11895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G31_RS11900	COG1960	acyl-CoA dehydrogenase activity
I6G31_RS11920	COG0644	oxidoreductase
I6G31_RS11925	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G31_RS11930	COG2271	Major facilitator Superfamily
I6G31_RS11935	COG0318	PFAM AMP-dependent synthetase and ligase
I6G31_RS11945	COG1924	4 iron, 4 sulfur cluster binding
I6G31_RS11960	COG2610	gluconate transmembrane transporter activity
I6G31_RS11965	COG1960	acyl-CoA dehydrogenase activity
I6G31_RS11970	COG2086	electron transfer activity
I6G31_RS11975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G31_RS11985	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G31_RS11990	COG4977	sequence-specific DNA binding
I6G31_RS12000	COG1309	transcriptional regulator
I6G31_RS12005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G31_RS12010	COG1027	Aspartate ammonia-lyase
I6G31_RS12020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G31_RS12025	COG0459	protein refolding
I6G31_RS12035	COG1509	lysine 2,3-aminomutase activity
I6G31_RS12040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G31_RS12045	COG0698	ribose 5-phosphate isomerase
I6G31_RS12050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G31_RS12055	COG0651	ATP synthesis coupled electron transport
I6G31_RS12060	COG0650	Formate hydrogenlyase subunit 4
I6G31_RS12065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G31_RS12070	COG4237	Hydrogenase 4 membrane
I6G31_RS12075	COG0651	ATP synthesis coupled electron transport
I6G31_RS12080	COG3261	NADH dehydrogenase
I6G31_RS12080	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G31_RS12085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G31_RS12090	COG3260	NADH ubiquinone oxidoreductase 20
I6G31_RS12100	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G31_RS12105	COG1216	Glycosyl transferase, family 2
I6G31_RS12120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G31_RS12130	COG1124	(ABC) transporter
I6G31_RS12140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G31_RS12145	COG1328	CTP reductase activity
I6G31_RS12150	COG3726	membrane protein affecting hemolysin expression
I6G31_RS12155	COG0560	Phosphoserine phosphatase
I6G31_RS12175	COG2382	esterase
I6G31_RS12205	COG2813	Specifically methylates the guanine in position
I6G31_RS12220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G31_RS12230	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G31_RS12235	COG0084	hydrolase, TatD family'
I6G31_RS12240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G31_RS12245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G31_RS12250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G31_RS12255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G31_RS12260	COG0813	purine-nucleoside phosphorylase activity
I6G31_RS12275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G31_RS12300	COG0469	pyruvate kinase activity
I6G31_RS12305	COG2271	Major facilitator Superfamily
I6G31_RS12330	COG1461	Dihydroxyacetone kinase
I6G31_RS12335	COG2376	Dihydroxyacetone kinase
I6G31_RS12400	COG4245	von Willebrand factor, type A
I6G31_RS12415	COG1358	cellular component organization or biogenesis
I6G31_RS12470	COG0840	transmembrane signaling receptor activity
I6G31_RS12480	COG3539	Fimbrial protein
I6G31_RS12495	COG3188	usher protein
I6G31_RS12520	COG0358	DNA primase activity
I6G31_RS12525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G31_RS12530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G31_RS12535	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G31_RS12540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G31_RS12545	COG0617	tRNA 3'-terminal CCA addition
I6G31_RS12550	COG4991	sh3 domain protein
I6G31_RS12555	COG3025	triphosphatase activity
I6G31_RS12560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G31_RS12565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G31_RS12565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G31_RS12570	COG2188	Transcriptional regulator
I6G31_RS12590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G31_RS12595	COG3384	dioxygenase
I6G31_RS12600	COG0754	glutathionylspermidine amidase activity
I6G31_RS12605	COG5463	Belongs to the UPF0441 family
I6G31_RS12610	COG1538	Outer membrane efflux protein
I6G31_RS12615	COG0494	nUDIX hydrolase
I6G31_RS12620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G31_RS12625	COG3150	esterase
I6G31_RS12630	COG0187	DNA topoisomerase II activity
I6G31_RS12640	COG0204	Acyl-transferase
I6G31_RS12645	COG2132	Multicopper oxidase
I6G31_RS12660	COG1280	lysine exporter protein (LysE YggA)
I6G31_RS12665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G31_RS12670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G31_RS12675	COG2967	ApaG domain
I6G31_RS12680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G31_RS12685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G31_RS12690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G31_RS12695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G31_RS12700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G31_RS12705	COG0564	pseudouridine synthase activity
I6G31_RS12710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G31_RS12715	COG0417	DNA replication proofreading
I6G31_RS12720	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G31_RS12725	COG1178	ABC-type Fe3 transport system permease component
I6G31_RS12730	COG4143	(ABC) transporter
I6G31_RS12735	COG0494	nUDIX hydrolase
I6G31_RS12745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G31_RS12750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G31_RS12775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G31_RS12785	COG1074	ATP-dependent DNA helicase activity
I6G31_RS12790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G31_RS12795	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G31_RS12795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G31_RS12800	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G31_RS12820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G31_RS12825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G31_RS12830	COG2166	iron-sulfur cluster assembly
I6G31_RS12835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G31_RS12840	COG0583	DNA-binding transcription factor activity
I6G31_RS12845	COG2363	Small membrane protein
I6G31_RS12850	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6G31_RS12855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G31_RS12860	COG1611	Belongs to the LOG family
I6G31_RS12865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G31_RS12865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G31_RS12880	COG0564	pseudouridine synthase activity
I6G31_RS12905	COG2171	N-acyltransferase activity
I6G31_RS12910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G31_RS12920	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G31_RS12925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G31_RS12930	COG0528	UMP kinase activity
I6G31_RS12935	COG0233	cytoplasmic translational termination
I6G31_RS12940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G31_RS12945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G31_RS12950	COG0575	Belongs to the CDS family
I6G31_RS12960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G31_RS12970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G31_RS12975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G31_RS12980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G31_RS12985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G31_RS12990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G31_RS13000	COG0825	malonyl-CoA metabolic process
I6G31_RS13010	COG0037	tRNA processing
I6G31_RS13015	COG4568	rho-dependent transcription termination
I6G31_RS13020	COG3015	lipoprotein NlpE involved in copper resistance
I6G31_RS13025	COG0442	prolyl-tRNA aminoacylation
I6G31_RS13030	COG1720	tRNA m6t6A37 methyltransferase activity
I6G31_RS13040	COG1464	Belongs to the NlpA lipoprotein family
I6G31_RS13045	COG2011	ABC-type metal ion transport system permease component
I6G31_RS13050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G31_RS13055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G31_RS13085	COG3021	interspecies interaction between organisms
I6G31_RS13110	COG0602	queuosine metabolic process
I6G31_RS13115	COG0720	synthase
I6G31_RS13120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G31_RS13130	COG0175	sulfate reduction
I6G31_RS13135	COG1648	precorrin-2 dehydrogenase activity
I6G31_RS13135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G31_RS13140	COG0175	sulfate reduction
I6G31_RS13145	COG2895	sulfate adenylyltransferase (ATP) activity
I6G31_RS13150	COG0529	Catalyzes the synthesis of activated sulfate
I6G31_RS13155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6G31_RS13160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G31_RS13165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G31_RS13170	COG0585	pseudouridine synthase activity
I6G31_RS13175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6G31_RS13180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G31_RS13185	COG4942	peptidase
I6G31_RS13185	COG1388	LysM domain
I6G31_RS13205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G31_RS13210	COG0582	viral genome integration into host DNA
I6G31_RS13220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G31_RS13230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G31_RS13245	COG1674	ftsk spoiiie
I6G31_RS13255	COG3423	Transcriptional regulator
I6G31_RS13345	COG2720	vancomycin resistance protein
I6G31_RS13365	COG3539	Fimbrial protein
I6G31_RS13380	COG3539	Fimbrial protein
I6G31_RS13390	COG0471	metal ion transport
I6G31_RS13395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G31_RS13400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G31_RS13410	COG0549	Belongs to the carbamate kinase family
I6G31_RS13420	COG0583	DNA-binding transcription factor activity
I6G31_RS13430	COG4589	Belongs to the CDS family
I6G31_RS13445	COG4566	intracellular signal transduction
I6G31_RS13465	COG2962	Rard protein
I6G31_RS13470	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G31_RS13480	COG0563	adenylate kinase activity
I6G31_RS13485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G31_RS13490	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6G31_RS13495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G31_RS13510	COG1902	pentaerythritol trinitrate reductase activity
I6G31_RS13515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G31_RS13515	COG4651	solute:proton antiporter activity
I6G31_RS13520	COG0737	Belongs to the 5'-nucleotidase family
I6G31_RS13530	COG3735	TraB family
I6G31_RS13555	COG0330	HflC and HflK could
I6G31_RS13560	COG3118	belongs to the thioredoxin family
I6G31_RS13565	COG0300	oxidoreductase activity
I6G31_RS13570	COG2755	lipolytic protein G-D-S-L family
I6G31_RS13575	COG4181	ATPase activity
I6G31_RS13580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G31_RS13585	COG1982	Orn Lys Arg decarboxylase major
I6G31_RS13590	COG0668	transmembrane transport
I6G31_RS13600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G31_RS13605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G31_RS13610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G31_RS13615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G31_RS13620	COG0215	cysteine-tRNA ligase activity
I6G31_RS13630	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G31_RS13635	COG2501	S4 domain
I6G31_RS13640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G31_RS13680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G31_RS13725	COG4725	Belongs to the MT-A70-like family
I6G31_RS13745	COG1403	HNH endonuclease
I6G31_RS13810	COG1802	Transcriptional regulator
I6G31_RS13810	COG4626	Terminase
I6G31_RS13910	COG0582	viral genome integration into host DNA
I6G31_RS14055	COG0800	Aldolase
I6G31_RS14060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G31_RS14075	COG3119	arylsulfatase activity
I6G31_RS14080	COG0641	radical SAM
I6G31_RS14085	COG1349	DNA-binding transcription factor activity
I6G31_RS14095	COG2222	sugar isomerase
I6G31_RS14100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G31_RS14105	COG3715	PTS system
I6G31_RS14110	COG3716	PTS system mannose fructose sorbose family IID component
I6G31_RS14115	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G31_RS14115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G31_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
I6G31_RS14160	COG3119	arylsulfatase activity
I6G31_RS14180	COG3038	cytochrome b561
I6G31_RS14185	COG2353	YceI-like domain
I6G31_RS14195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G31_RS14210	COG1115	amino acid carrier protein
I6G31_RS14220	COG1151	hydroxylamine reductase activity
I6G31_RS14225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G31_RS14235	COG2239	Acts as a magnesium transporter
I6G31_RS14240	COG3091	SprT-like family
I6G31_RS14245	COG0640	Transcriptional regulator
I6G31_RS14260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G31_RS14265	COG1166	arginine decarboxylase activity
I6G31_RS14270	COG0010	Belongs to the arginase family
I6G31_RS14280	COG3066	DNA modification
I6G31_RS14285	COG4533	DNA binding
I6G31_RS14290	COG0066	3-isopropylmalate dehydratase activity
I6G31_RS14295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G31_RS14300	COG0473	3-isopropylmalate dehydrogenase activity
I6G31_RS14305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G31_RS14315	COG1022	Amp-dependent synthetase and ligase
I6G31_RS14325	COG2001	Belongs to the MraZ family
I6G31_RS14330	COG0275	rRNA processing
I6G31_RS14340	COG0768	penicillin binding
I6G31_RS14345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G31_RS14350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G31_RS14355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G31_RS14360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G31_RS14365	COG0772	Belongs to the SEDS family
I6G31_RS14370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G31_RS14375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G31_RS14385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G31_RS14390	COG0849	cell division
I6G31_RS14395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G31_RS14400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6G31_RS14415	COG0653	protein targeting
I6G31_RS14445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G31_RS14450	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6G31_RS14455	COG0237	dephospho-CoA kinase activity
I6G31_RS14460	COG1459	type II secretion system
I6G31_RS14465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G31_RS14470	COG4969	Belongs to the N-Me-Phe pilin family
I6G31_RS14475	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G31_RS14485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G31_RS14490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G31_RS14495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G31_RS14505	COG3112	Uncharacterised protein family (UPF0231)
I6G31_RS14515	COG1279	arginine transmembrane transporter activity
I6G31_RS14525	COG0583	DNA-binding transcription factor activity
I6G31_RS14530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G31_RS14535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G31_RS14540	COG2274	protein secretion by the type I secretion system
I6G31_RS14555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G31_RS14565	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6G31_RS14570	COG3079	Belongs to the UPF0149 family
I6G31_RS14575	COG0006	proline dipeptidase activity
I6G31_RS14580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G31_RS14585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G31_RS14590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G31_RS14595	COG0509	glycine decarboxylation via glycine cleavage system
I6G31_RS14600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G31_RS14600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G31_RS14610	COG0354	folic acid binding
I6G31_RS14615	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G31_RS14625	COG0716	FMN binding
I6G31_RS14635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G31_RS14640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G31_RS14650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G31_RS14660	COG0840	transmembrane signaling receptor activity
I6G31_RS14725	COG2841	Protein conserved in bacteria
I6G31_RS14730	COG4574	serine-type endopeptidase inhibitor activity
I6G31_RS14735	COG0589	response to stress
I6G31_RS14740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G31_RS14750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G31_RS14755	COG1085	galactose-1-phosphate uridylyltransferase
I6G31_RS14760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G31_RS14765	COG2017	converts alpha-aldose to the beta-anomer
I6G31_RS14770	COG1609	Transcriptional regulator
I6G31_RS14800	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G31_RS14815	COG1556	Lactate utilization protein
I6G31_RS14820	COG1139	Iron-sulfur cluster binding protein
I6G31_RS14825	COG0247	lactate metabolic process
I6G31_RS14830	COG1620	l-lactate permease
I6G31_RS14840	COG0583	DNA-binding transcription factor activity
I6G31_RS14845	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G31_RS14850	COG0840	transmembrane signaling receptor activity
I6G31_RS14860	COG0384	phenazine biosynthesis protein PhzF
I6G31_RS14865	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6G31_RS14875	COG2205	protein histidine kinase activity
I6G31_RS14880	COG0745	RESPONSE REGULATOR receiver
I6G31_RS14915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G31_RS14920	COG2867	negative regulation of translational initiation
I6G31_RS14925	COG2914	Belongs to the UPF0125 (RnfH) family
I6G31_RS14935	COG0497	DNA recombination
I6G31_RS14940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G31_RS14945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G31_RS14950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G31_RS14955	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6G31_RS14960	COG0513	Belongs to the DEAD box helicase family
I6G31_RS14965	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G31_RS14970	COG1595	DNA-templated transcription, initiation
I6G31_RS14975	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6G31_RS14980	COG3026	antisigma factor binding
I6G31_RS14985	COG3086	response to oxidative stress
I6G31_RS14990	COG0481	GTPase activity
I6G31_RS14995	COG0681	Belongs to the peptidase S26 family
I6G31_RS15000	COG0571	ribonuclease III activity
I6G31_RS15005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G31_RS15010	COG1381	Involved in DNA repair and RecF pathway recombination
I6G31_RS15015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G31_RS15020	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G31_RS15025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G31_RS15035	COG3539	Fimbrial protein
I6G31_RS15040	COG3539	Fimbrial protein
I6G31_RS15045	COG3121	Chaperone
I6G31_RS15050	COG3188	usher protein
I6G31_RS15055	COG3539	Fimbrial protein
I6G31_RS15060	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G31_RS15065	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G31_RS15065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G31_RS15070	COG2205	protein histidine kinase activity
I6G31_RS15075	COG3170	Tfp pilus assembly protein FimV
I6G31_RS15080	COG2204	response regulator
I6G31_RS15085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G31_RS15085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G31_RS15090	COG0347	Belongs to the P(II) protein family
I6G31_RS15100	COG1017	nitric oxide dioxygenase activity
I6G31_RS15100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G31_RS15105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G31_RS15110	COG2814	Major facilitator Superfamily
I6G31_RS15115	COG0483	inositol monophosphate 1-phosphatase activity
I6G31_RS15120	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G31_RS15125	COG1959	2 iron, 2 sulfur cluster binding
I6G31_RS15130	COG1104	cysteine desulfurase activity
I6G31_RS15135	COG0822	iron-sulfur transferase activity
I6G31_RS15140	COG0316	Belongs to the HesB IscA family
I6G31_RS15145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G31_RS15150	COG0443	Heat shock 70 kDa protein
I6G31_RS15155	COG0633	Ferredoxin
I6G31_RS15160	COG2975	iron-sulfur cluster assembly
I6G31_RS15165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G31_RS15175	COG2373	Large extracellular alpha-helical protein
I6G31_RS15180	COG4953	penicillin-binding protein 1C
I6G31_RS15185	COG0105	UTP biosynthetic process
I6G31_RS15190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G31_RS15205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G31_RS15210	COG0124	histidyl-tRNA synthetase
I6G31_RS15215	COG2976	Protein conserved in bacteria
I6G31_RS15220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G31_RS15225	COG1160	GTP binding
I6G31_RS15235	COG0408	coproporphyrinogen oxidase activity
I6G31_RS15240	COG0456	acetyltransferase
I6G31_RS15250	COG2837	iron assimilation
I6G31_RS15260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G31_RS15265	COG4208	sulfate ABC transporter
I6G31_RS15270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G31_RS15275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G31_RS15280	COG2190	(PTS) system
I6G31_RS15285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G31_RS15290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G31_RS15295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G31_RS15310	COG3115	cell septum assembly
I6G31_RS15315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G31_RS15320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G31_RS15325	COG3530	Putative quorum-sensing-regulated virulence factor
I6G31_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
I6G31_RS15350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G31_RS15390	COG1396	sequence-specific DNA binding
I6G31_RS15415	COG2207	Transcriptional regulator
I6G31_RS15475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G31_RS15555	COG0305	Participates in initiation and elongation during chromosome replication
I6G31_RS15820	COG2067	long-chain fatty acid transport protein
I6G31_RS15825	COG3691	Protein conserved in bacteria
I6G31_RS15830	COG0183	Belongs to the thiolase family
I6G31_RS15835	COG1024	Enoyl-CoA hydratase
I6G31_RS15835	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G31_RS15845	COG2840	Smr protein MutS2
I6G31_RS15860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G31_RS15865	COG0730	response to heat
I6G31_RS15870	COG3101	peptidyl-lysine hydroxylation
I6G31_RS15890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G31_RS15890	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G31_RS15895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G31_RS15900	COG0697	spore germination
I6G31_RS15905	COG2207	Transcriptional regulator
I6G31_RS15910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G31_RS15915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G31_RS15925	COG0586	Pfam SNARE associated Golgi protein
I6G31_RS15930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G31_RS15935	COG0285	dihydrofolate synthase activity
I6G31_RS15940	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G31_RS15945	COG1286	toxin biosynthetic process
I6G31_RS15950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G31_RS15955	COG0163	prenyltransferase activity
I6G31_RS15960	COG1090	epimerase
I6G31_RS15965	COG0625	glutathione transferase activity
I6G31_RS15970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G31_RS15975	COG1609	Transcriptional regulator
I6G31_RS15980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G31_RS15990	COG3037	sugar-specific permease SgaT UlaA
I6G31_RS16005	COG0857	belongs to the CobB CobQ family
I6G31_RS16005	COG0280	phosphate acetyltransferase
I6G31_RS16010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G31_RS16015	COG3092	negative regulation of chromosome organization
I6G31_RS16020	COG3013	Belongs to the UPF0304 family
I6G31_RS16025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G31_RS16030	COG0490	domain, Protein
I6G31_RS16030	COG0471	metal ion transport
I6G31_RS16040	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G31_RS16045	COG0436	Aminotransferase
I6G31_RS16050	COG0583	DNA-binding transcription factor activity
I6G31_RS16055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G31_RS16060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G31_RS16065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G31_RS16065	COG0649	NAD binding
I6G31_RS16075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6G31_RS16085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6G31_RS16090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G31_RS16095	COG0839	Belongs to the complex I subunit 6 family
I6G31_RS16100	COG0713	ATP synthesis coupled electron transport
I6G31_RS16105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G31_RS16110	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G31_RS16115	COG1007	ATP synthesis coupled electron transport
I6G31_RS16130	COG1169	isochorismate synthase
I6G31_RS16135	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G31_RS16140	COG0596	Alpha beta hydrolase
I6G31_RS16145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G31_RS16150	COG1441	menaquinone biosynthetic process
I6G31_RS16175	COG0814	amino acid
I6G31_RS16185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G31_RS16190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G31_RS16195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G31_RS16200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G31_RS16210	COG2205	protein histidine kinase activity
I6G31_RS16210	COG0784	Response regulator, receiver
I6G31_RS16245	COG3708	Transcriptional regulator
I6G31_RS16245	COG2207	Transcriptional regulator
I6G31_RS16260	COG3302	dmso reductase anchor subunit
I6G31_RS16265	COG0437	4 iron, 4 sulfur cluster binding
I6G31_RS16270	COG0243	molybdopterin cofactor binding
I6G31_RS16275	COG0668	transmembrane transport
I6G31_RS16290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G31_RS16305	COG1902	pentaerythritol trinitrate reductase activity
I6G31_RS16325	COG1607	acyl-coa hydrolase
I6G31_RS16340	COG2814	Major facilitator Superfamily
I6G31_RS16345	COG1560	Kdo2-lipid A biosynthetic process
I6G31_RS16385	COG0418	dihydroorotase activity
I6G31_RS16405	COG2207	Transcriptional regulator
I6G31_RS16410	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G31_RS16435	COG1285	pathogenesis
I6G31_RS16450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G31_RS16455	COG1360	Flagellar Motor Protein
I6G31_RS16465	COG0835	chemotaxis
I6G31_RS16470	COG0840	transmembrane signaling receptor activity
I6G31_RS16475	COG0840	transmembrane signaling receptor activity
I6G31_RS16485	COG2201	protein-glutamate methylesterase activity
I6G31_RS16490	COG0745	RESPONSE REGULATOR receiver
I6G31_RS16500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G31_RS16540	COG1815	bacterial-type flagellum-dependent cell motility
I6G31_RS16545	COG1558	bacterial-type flagellum-dependent cell motility
I6G31_RS16570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G31_RS16575	COG1706	bacterial-type flagellum-dependent cell motility
I6G31_RS16610	COG1987	bacterial-type flagellum assembly
I6G31_RS16615	COG1338	Plays a role in the flagellum-specific transport system
I6G31_RS16635	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G31_RS16645	COG2882	bacterial-type flagellum organization
I6G31_RS16650	COG1157	protein secretion by the type III secretion system
I6G31_RS16655	COG1317	bacterial-type flagellum organization
I6G31_RS16670	COG1677	Flagellar hook-basal body complex protein FliE
I6G31_RS16710	COG1191	sigma factor activity
I6G31_RS16720	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G31_RS16720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G31_RS16720	COG0506	proline dehydrogenase activity
I6G31_RS16725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G31_RS16750	COG3188	usher protein
I6G31_RS16765	COG3121	Chaperone
I6G31_RS16775	COG1113	amino acid transport
I6G31_RS16790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G31_RS16795	COG0589	response to stress
I6G31_RS16805	COG2226	methyltransferase
I6G31_RS16810	COG1971	Probably functions as a manganese efflux pump
I6G31_RS16815	COG1760	l-serine dehydratase
I6G31_RS16825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G31_RS16830	COG3140	Belongs to the UPF0181 family
I6G31_RS16845	COG1115	amino acid carrier protein
I6G31_RS16850	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G31_RS16855	COG1114	Component of the transport system for branched-chain amino acids
I6G31_RS16860	COG0561	phosphatase activity
I6G31_RS16875	COG1113	amino acid transport
I6G31_RS16890	COG0351	phosphomethylpyrimidine kinase
I6G31_RS16895	COG1830	Aldolase
I6G31_RS16900	COG1597	lipid kinase activity
I6G31_RS16905	COG0826	peptidase U32
I6G31_RS16910	COG0745	RESPONSE REGULATOR receiver
I6G31_RS16915	COG2205	protein histidine kinase activity
I6G31_RS16920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G31_RS16925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G31_RS16930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G31_RS16935	COG3104	oligopeptide transport
I6G31_RS16950	COG2239	Acts as a magnesium transporter
I6G31_RS16955	COG0248	Ppx GppA phosphatase
I6G31_RS16960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G31_RS16965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G31_RS16970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G31_RS16975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G31_RS16980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G31_RS16985	COG2233	PERMEase
I6G31_RS16995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G31_RS17000	COG2211	Major facilitator Superfamily
I6G31_RS17005	COG1393	Belongs to the ArsC family
I6G31_RS17010	COG4783	chaperone-mediated protein folding
I6G31_RS17015	COG0628	permease
I6G31_RS17020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G31_RS17025	COG2716	regulation of RNA biosynthetic process
I6G31_RS17030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G31_RS17035	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G31_RS17045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G31_RS17055	COG2378	regulation of single-species biofilm formation
I6G31_RS17060	COG2321	neutral zinc metallopeptidase
I6G31_RS17065	COG2707	UPF0756 membrane protein
I6G31_RS17070	COG1444	tRNA N-acetyltransferase activity
I6G31_RS17080	COG2832	Protein of unknown function (DUF454)
I6G31_RS17085	COG1876	peptidase activity
I6G31_RS17090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G31_RS17095	COG1393	Belongs to the ArsC family
I6G31_RS17105	COG2197	response regulator
I6G31_RS17110	COG0280	phosphate acetyltransferase
I6G31_RS17110	COG0281	malic enzyme
I6G31_RS17125	COG1770	oligopeptidase
I6G31_RS17135	COG1570	exodeoxyribonuclease VII activity
I6G31_RS17140	COG0517	IMP dehydrogenase activity
I6G31_RS17140	COG0516	GMP reductase activity
I6G31_RS17145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G31_RS17145	COG0519	Catalyzes the synthesis of GMP from XMP
I6G31_RS17150	COG3541	Predicted nucleotidyltransferase
I6G31_RS17165	COG1324	tolerance protein
I6G31_RS17170	COG2390	Transcriptional regulator
I6G31_RS17175	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G31_RS17180	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G31_RS17185	COG3842	ATPase activity
I6G31_RS17235	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6G31_RS17240	COG1494	fructose-1,6-bisphosphatase
I6G31_RS17255	COG2197	response regulator
I6G31_RS17260	COG0322	excinuclease ABC activity
I6G31_RS17265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G31_RS17315	COG2076	Multidrug Resistance protein
I6G31_RS17325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G31_RS17330	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G31_RS17335	COG2186	Transcriptional regulator
I6G31_RS17340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G31_RS17345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G31_RS17350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G31_RS17355	COG3713	MltA-interacting MipA family protein
I6G31_RS17370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G31_RS17375	COG3139	Protein of unknown function (DUF1315)
I6G31_RS17380	COG1335	isochorismatase
I6G31_RS17385	COG0252	asparaginase activity
I6G31_RS17390	COG0616	signal peptide processing
I6G31_RS17395	COG0778	Nitroreductase
I6G31_RS17400	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G31_RS17405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G31_RS17410	COG0708	Exodeoxyribonuclease III
I6G31_RS17415	COG0583	DNA-binding transcription factor activity
I6G31_RS17425	COG0788	formyltetrahydrofolate deformylase activity
I6G31_RS17430	COG3012	SEC-C Motif Domain Protein
I6G31_RS17435	COG0745	RESPONSE REGULATOR receiver
I6G31_RS17440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G31_RS17450	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G31_RS17455	COG1435	thymidine kinase activity
I6G31_RS17460	COG1454	alcohol dehydrogenase
I6G31_RS17460	COG1012	belongs to the aldehyde dehydrogenase family
I6G31_RS17465	COG2095	MarC family integral membrane protein
I6G31_RS17470	COG4608	Belongs to the ABC transporter superfamily
I6G31_RS17475	COG0444	Belongs to the ABC transporter superfamily
I6G31_RS17480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G31_RS17485	COG0601	transmembrane transport
I6G31_RS17505	COG0601	transmembrane transport
I6G31_RS17510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G31_RS17515	COG0444	Belongs to the ABC transporter superfamily
I6G31_RS17525	COG1396	sequence-specific DNA binding
I6G31_RS17535	COG3539	Fimbrial protein
I6G31_RS17545	COG3188	usher protein
I6G31_RS17560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G31_RS17565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G31_RS17570	COG1309	transcriptional regulator
I6G31_RS17575	COG1012	belongs to the aldehyde dehydrogenase family
I6G31_RS17580	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G31_RS17585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G31_RS17590	COG0402	S-adenosylhomocysteine deaminase activity
I6G31_RS17610	COG0113	porphobilinogen synthase activity
I6G31_RS17630	COG0589	response to stress
I6G31_RS17640	COG0589	response to stress
I6G31_RS17645	COG2966	Psort location CytoplasmicMembrane, score
I6G31_RS17650	COG3610	response to peptide
I6G31_RS17660	COG2356	endonuclease I
I6G31_RS17670	COG1702	phosphate starvation-inducible protein PhoH
I6G31_RS17680	COG3121	Chaperone
I6G31_RS17685	COG3188	usher protein