locus-tag class description H0910_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H0910_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H0910_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H0910_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0910_RS00025 ENOG4105YVM Phosphoesterase, PA-phosphatase related H0910_RS00030 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0910_RS00035 ENOG4105CNH Multidrug resistance protein MdtL H0910_RS00105 ENOG4105D2S major facilitator superfamily H0910_RS00145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H0910_RS00150 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H0910_RS00155 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H0910_RS00160 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H0910_RS00165 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H0910_RS00170 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H0910_RS00175 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0910_RS00180 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0910_RS00185 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0910_RS00190 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) H0910_RS00195 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation H0910_RS00200 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) H0910_RS00205 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H0910_RS00210 ENOG4105QTB Flavodoxin H0910_RS00215 ENOG4108VVK transcriptional Regulator, AsnC H0910_RS00220 ENOG4105CU9 asparagine synthetase A H0910_RS00225 ENOG4105EV2 VWA domain protein interacting with AAA ATPase H0910_RS00230 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) H0910_RS00235 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) H0910_RS00240 ENOG4105C2J ABC transporter H0910_RS00245 ENOG4105CNN ABC, transporter H0910_RS00250 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0910_RS00255 ENOG4108RVA ribokinase H0910_RS00260 ENOG4105ETE Transcriptional regulator (LacI family H0910_RS00265 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0910_RS00270 ENOG4107EJG GntR family transcriptional regulator H0910_RS00305 ENOG4107QN1 sodium solute H0910_RS00310 ENOG41062QD Membrane H0910_RS00315 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H0910_RS00320 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0910_RS00325 ENOG4108RPX mosc domain containing protein H0910_RS00330 ENOG4105EJC lysr family transcriptional regulator H0910_RS00335 ENOG4105EUB pirin domain protein H0910_RS00345 ENOG4105C31 Tryptophanyl-tRNA synthetase H0910_RS00350 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H0910_RS00355 ENOG4105DJV ribulose-phosphate 3-epimerase H0910_RS00370 ENOG4105D49 3-dehydroquinate synthase H0910_RS00375 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H0910_RS00380 ENOG4105E4G Type IV pilus H0910_RS00400 ENOG4108JQC penicillin-binding protein 1A H0910_RS00405 ENOG4107RK2 ADP-ribose diphosphatase NudE H0910_RS00410 ENOG4105DQY intracellular growth attenuator H0910_RS00415 ENOG4105VEJ Heat shock protein H0910_RS00420 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) H0910_RS00425 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase H0910_RS00430 ENOG4105C2I pirin domain protein H0910_RS00435 ENOG4105CBX hi0933 family H0910_RS00440 ENOG4105CJ3 phosphate transporter H0910_RS00445 ENOG4108V6B universal stress protein B H0910_RS00455 ENOG4105D82 Glutamate dehydrogenase H0910_RS00460 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) H0910_RS00465 ENOG4105DGW oligopeptidase A H0910_RS00475 ENOG4105DFP Integrase H0910_RS00490 ENOG4108BUD transposase H0910_RS00570 ENOG4108QDQ Ubiquinol-cytochrome C chaperone H0910_RS00595 ENOG4106549 Antirestriction protein H0910_RS00600 ENOG4105MFG Antirestriction protein H0910_RS00605 ENOG4106H6R UPF0380 protein H0910_RS00610 ENOG4108XS9 dna repair protein H0910_RS00615 ENOG4105ZS6 Protein of unknown function (DUF987) H0910_RS00655 ENOG4105WT3 Transcriptional regulator H0910_RS00670 ENOG4106PG1 outer membrane usher protein H0910_RS00675 ENOG4108FZ9 Chaperone H0910_RS00710 ENOG4108YYI Protein of unknown function (DUF2810) H0910_RS00725 ENOG4106PG1 outer membrane usher protein H0910_RS00730 ENOG4106P2F Pfam:Pili_assembly_C H0910_RS00770 ENOG4108FZ9 Chaperone H0910_RS00775 ENOG4106PG1 outer membrane usher protein H0910_RS00795 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme H0910_RS00800 ENOG4105D3G Pseudouridine synthase H0910_RS00805 ENOG4105VEQ Cold shock protein H0910_RS00825 ENOG4108N3D putative enzyme H0910_RS00830 ENOG4106PYX Receptor H0910_RS00840 ENOG4107QY8 reductase H0910_RS00845 ENOG4105QAX Iron-sulfur H0910_RS00850 ENOG4107KGK dmso reductase anchor subunit H0910_RS00855 ENOG4108NEM leader-binding protein dmsD H0910_RS00860 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) H0910_RS00870 ENOG4107ZY3 Histidine kinase H0910_RS00875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0910_RS00880 ENOG4105DZC cytosine deaminase H0910_RS00885 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin H0910_RS00895 ENOG4105CH2 amidohydrolase H0910_RS00900 ENOG4105CE7 Amidase, hydantoinase carbamoylase family H0910_RS00905 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) H0910_RS00915 ENOG4105TNG K13735 adhesin invasin H0910_RS00945 ENOG4108RBT type iii secretion H0910_RS00965 ENOG4108K2B transcriptional regulator H0910_RS00980 ENOG4108HR8 type iii secretion H0910_RS01000 ENOG4105NIV Esterase H0910_RS01005 ENOG4105D05 Receptor H0910_RS01010 ENOG4105CW7 secretion protein, HlyD family H0910_RS01015 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0910_RS01020 ENOG4108Z0R Transferase H0910_RS01025 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein H0910_RS01030 ENOG4105DZS Phenylacetate-CoA ligase H0910_RS01035 ENOG4105CHU acetyl-coa acetyltransferase H0910_RS01040 ENOG4108ZJI phenylacetic acid degradation protein H0910_RS01045 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H0910_RS01050 ENOG4108UKI Enoyl-CoA hydratase H0910_RS01055 ENOG4105E39 Enoyl-CoA hydratase H0910_RS01060 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0910_RS01065 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit H0910_RS01070 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit H0910_RS01075 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit H0910_RS01080 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit H0910_RS01085 ENOG4105DXM phenylacetic acid degradation protein H0910_RS01100 ENOG4105N0V mono-oxygenase ydhR H0910_RS01115 ENOG4105CVP deoxyribo-dipyrimidine photolyase H0910_RS01120 ENOG4105CSH Transporter H0910_RS01125 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0910_RS01130 ENOG4105C7K acetolactate synthase H0910_RS01135 ENOG4105D03 DNA-3-methyladenine glycosylase II H0910_RS01145 ENOG4105K78 MarR family Transcriptional regulator H0910_RS01155 ENOG4105C5H ABC transporter H0910_RS01160 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H0910_RS01165 ENOG4105E98 transcriptional regulator DeoR family H0910_RS01170 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) H0910_RS01175 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) H0910_RS01180 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) H0910_RS01185 ENOG4105MJ2 Competence protein H0910_RS01190 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) H0910_RS01205 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) H0910_RS01210 ENOG4105CE1 Ferrous iron transport protein b H0910_RS01215 ENOG4105XFK Ferrous iron transport protein A H0910_RS01220 ENOG4105BZM domain protein H0910_RS01225 ENOG4108RRZ Transcription elongation factor GreB H0910_RS01235 ENOG4105E0F Histidine kinase H0910_RS01240 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H0910_RS01245 ENOG4105C8U phosphate abc transporter H0910_RS01250 ENOG4105E2Z phosphate ABC transporter (Permease H0910_RS01260 ENOG4108UTW Plays a role in the regulation of phosphate uptake H0910_RS01265 ENOG4105CT1 (ABC) transporter H0910_RS01270 ENOG4105E5Q amino acid AbC transporter H0910_RS01275 ENOG4105DRP amino acid AbC transporter H0910_RS01280 ENOG4105C7N Xanthine uracil vitamin C permease H0910_RS01290 ENOG4105D4P Coproporphyrinogen iii oxidase H0910_RS01295 ENOG41066YJ Beta-lactamase H0910_RS01300 ENOG4105ETT transcriptional Regulator, LysR family H0910_RS01310 ENOG4108IMY Transcriptional regulator H0910_RS01335 ENOG4105CW0 outer membrane usher protein H0910_RS01380 ENOG4105CW0 outer membrane usher protein H0910_RS01390 ENOG4108ZI2 Fimbrial protein H0910_RS01410 ENOG4105CW0 outer membrane usher protein H0910_RS01415 ENOG4108VCD Chaperone H0910_RS01440 ENOG4105NTW Transcriptional regulator H0910_RS01445 ENOG4105CI3 gtp-binding protein typa H0910_RS01450 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 H0910_RS01455 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H0910_RS01460 ENOG4105SUU thioesterase domain H0910_RS01465 ENOG4105JV1 AsmA family H0910_RS01470 ENOG4105C2W permease H0910_RS01475 ENOG4105D6U Sodium Glutamate Symporter H0910_RS01480 ENOG4105CB5 ATP-dependent DNA helicase recG H0910_RS01485 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase H0910_RS01490 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0910_RS01500 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H0910_RS01505 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) H0910_RS01510 ENOG4105EN6 Membrane H0910_RS01515 ENOG4105D99 atp gtp-binding protein H0910_RS01520 ENOG4105R2A (LipO)protein H0910_RS01525 ENOG4105D0C transport protein H0910_RS01530 ENOG4105JKW Valine--pyruvate aminotransferase H0910_RS01535 ENOG4108R3E Dna-3-methyladenine glycosylase i H0910_RS01545 ENOG4105C38 Glycyl-tRNA synthetase beta subunit H0910_RS01555 ENOG4105DEF Extracellular solute-binding protein, family 5 H0910_RS01560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0910_RS01565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0910_RS01570 ENOG4105C3U ABC transporter H0910_RS01575 ENOG4108JQ7 (ABC) transporter H0910_RS01580 ENOG4105BZU Histidine kinase H0910_RS01585 ENOG4105CS0 peptidase H0910_RS01595 ENOG4105EA8 2-Nitropropane dioxygenase H0910_RS01600 ENOG4107H3J ribonuclease H0910_RS01610 ENOG4105D6S protein involved in catabolism of external DNA H0910_RS01615 ENOG4105DC8 reductase H0910_RS01625 ENOG4108X7A Terpene synthase metal-binding domain-containing protein H0910_RS01635 ENOG4105D29 Helix-turn-helix type 11 domain protein H0910_RS01655 ENOG4108IJ9 (ABC) transporter H0910_RS01660 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H0910_RS01670 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b H0910_RS01675 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H0910_RS01680 ENOG4105PC1 Conserved Protein H0910_RS01685 ENOG4105E27 serine threonine protein kinase H0910_RS01690 ENOG4108Z33 Thiol disulfide Interchange Protein H0910_RS01695 ENOG4105C2M dna polymerase I H0910_RS01700 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) H0910_RS01705 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0910_RS01715 ENOG4105C8Y Acetylornithine aminotransferase H0910_RS01735 ENOG4108UKZ OsmC family H0910_RS01740 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) H0910_RS01745 ENOG4105YP7 UPF0270 protein H0910_RS01750 ENOG4105DNZ Alpha Beta Hydrolase H0910_RS01760 ENOG4105C5Y PTS System H0910_RS01765 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H0910_RS01770 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) H0910_RS01775 ENOG4105CXN decarboxylase H0910_RS01790 ENOG4105C5H ABC transporter H0910_RS01795 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein H0910_RS01805 ENOG4105VKU nucleicacid-binding protein H0910_RS01810 ENOG4108YZY peptidylprolyl cis-trans isomerase H0910_RS01820 ENOG4105VRX Protein slyX homolog H0910_RS01825 ENOG4108V1T peptidylprolyl cis-trans isomerase H0910_RS01835 ENOG4105WWK YheO domain protein H0910_RS01840 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) H0910_RS01855 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H0910_RS01860 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H0910_RS01865 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H0910_RS01870 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H0910_RS01875 ENOG4105PM1 preprotein translocase subunit SecE H0910_RS01880 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H0910_RS01885 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H0910_RS01895 ENOG4108VZM 50s ribosomal protein L10 H0910_RS01900 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) H0910_RS01905 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0910_RS01910 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0910_RS01930 ENOG4105CEE C4-dicarboxylate transporter H0910_RS01935 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H0910_RS01940 ENOG4105D41 biosynthesis protein thiH H0910_RS01945 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H0910_RS01950 ENOG4105WHD thiamine biosynthesis protein ThiS H0910_RS01955 ENOG4105D06 uba thif-type nad fad binding protein H0910_RS01960 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H0910_RS01965 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) H0910_RS01975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0910_RS01985 ENOG4108I5D sulfate abc transporter H0910_RS01995 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H0910_RS02000 ENOG4105E09 nadh pyrophosphatase H0910_RS02005 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H0910_RS02010 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) H0910_RS02015 ENOG4105R2J Conserved Protein H0910_RS02025 ENOG4108T8B Protein of unknown function (DUF1481) H0910_RS02030 ENOG4105C12 Phosphoribosylglycinamide synthetase H0910_RS02035 ENOG4105DC1 bifunctional purine biosynthesis protein purh H0910_RS02065 ENOG4107QP3 malate synthase g H0910_RS02070 ENOG4108I9X Isocitrate lyase H0910_RS02075 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) H0910_RS02080 ENOG4108UHU Aldolase H0910_RS02085 ENOG4105C01 Dihydroxy-acid dehydratase H0910_RS02100 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H0910_RS02105 ENOG41069M3 Transcriptional regulator H0910_RS02110 ENOG4105C3R Methionine synthase H0910_RS02130 ENOG4105CFH Aspartokinase H0910_RS02135 ENOG4107QP8 phosphohexose isomerase H0910_RS02140 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) H0910_RS02145 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) H0910_RS02150 ENOG4105E55 glycerol-3-phosphate acyltransferase H0910_RS02155 ENOG41080IJ Diacylglycerol kinase H0910_RS02160 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) H0910_RS02165 ENOG4105MYN Zinc uptake regulation protein H0910_RS02175 ENOG4106PG1 outer membrane usher protein H0910_RS02180 ENOG4106P2F Pfam:Pili_assembly_C H0910_RS02220 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0910_RS02225 ENOG4108BSC Methyltransferase H0910_RS02230 ENOG4105E0A ABC, transporter H0910_RS02235 ENOG4105EHG Permease protein H0910_RS02245 ENOG4105DIQ Transcriptional regulator H0910_RS02250 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H0910_RS02255 ENOG4105C6Z Gluconate H0910_RS02295 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H0910_RS02300 ENOG4108UR8 BAX protein H0910_RS02330 ENOG4105Y3E Modulates RecA activity (By similarity) H0910_RS02335 ENOG4105CEE C4-dicarboxylate transporter H0910_RS02340 ENOG4105C44 Serine transporter H0910_RS02345 ENOG4108IQK o-acetylhomoserine H0910_RS02350 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) H0910_RS02360 ENOG4105BZS acriflavin resistance protein H0910_RS02365 ENOG410624X efflux transporter, rnd family, mfp subunit H0910_RS02370 ENOG4108Z4X TRANSCRIPTIONal H0910_RS02390 ENOG4106IPI cyclase, family H0910_RS02435 ENOG4105ERH Fumarylacetoacetate hydrolase H0910_RS02455 ENOG4105EEQ Na H antiporter H0910_RS02475 ENOG4105EW6 flavin reductase domain protein, FMN-binding H0910_RS02485 ENOG4105HMV Fimbrial protein H0910_RS02495 ENOG4106PG1 outer membrane usher protein H0910_RS02500 ENOG4106P2F Pfam:Pili_assembly_C H0910_RS02535 ENOG410662B Type-1 fimbrial protein H0910_RS02540 ENOG4105CW0 outer membrane usher protein H0910_RS02545 ENOG4108MQF Chaperone H0910_RS02560 ENOG4105TNG K13735 adhesin invasin H0910_RS02570 ENOG4107FB0 transcriptional regulator DeoR family H0910_RS02575 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) H0910_RS02585 ENOG4105EDR glucose galactose transporter H0910_RS02600 ENOG4105D64 Mechanosensitive ion channel H0910_RS02605 ENOG4105CXN decarboxylase H0910_RS02610 ENOG4105DU0 nucleoside hydrolase H0910_RS02625 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0910_RS02635 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H0910_RS02640 ENOG4105CDU Replicative dna helicase H0910_RS02645 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0910_RS02650 ENOG4105CGF Aromatic amino acid aminotransferase H0910_RS02655 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H0910_RS02660 ENOG4108UUM single-stranded DNA-binding protein H0910_RS02670 ENOG4105C7K acetolactate synthase H0910_RS02675 ENOG4105M71 acetolactate synthase 1 regulatory subunit H0910_RS02695 ENOG4105C7N Xanthine uracil vitamin C permease H0910_RS02700 ENOG4105EEQ Na H antiporter H0910_RS02705 ENOG4105EMK carboxylate amino acid amine transporter H0910_RS02710 ENOG4105DZ2 Transcriptional regulator H0910_RS02715 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H0910_RS02725 ENOG4105ZXK Dehydrogenase H0910_RS02730 ENOG4105G63 Type III effector Hrp-dependent H0910_RS02735 ENOG4105FB2 class II Aldolase H0910_RS02740 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H0910_RS02745 ENOG4105MVE transcriptional regulator H0910_RS02750 ENOG4105EXW epimerase dehydratase H0910_RS02755 ENOG4105C6Z Gluconate H0910_RS02760 ENOG4108I5U Uridine phosphorylase H0910_RS02770 ENOG4108KF1 Membrane H0910_RS02775 ENOG4105CGY Dna recombination protein H0910_RS02780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H0910_RS02785 ENOG4105JC1 sterol-binding domain protein H0910_RS02790 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) H0910_RS02795 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H0910_RS02800 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) H0910_RS02805 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H0910_RS02810 ENOG4105MDZ Transcriptional activator rfaH H0910_RS02815 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) H0910_RS02820 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H0910_RS02830 ENOG4105CHU acetyl-coa acetyltransferase H0910_RS02835 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H0910_RS02840 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) H0910_RS02845 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H0910_RS02850 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) H0910_RS02855 ENOG4108RR8 protoporphyrinogen oxidase H0910_RS02880 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) H0910_RS02885 ENOG4105WH1 Two component transcriptional regulator luxr family H0910_RS02890 ENOG4105BZU Histidine kinase H0910_RS02895 ENOG4105CKW Inner membrane protein yedI H0910_RS02900 ENOG4105K64 Glycosyl transferase, family 2 H0910_RS02910 ENOG4105CJP fad dependent oxidoreductase H0910_RS02920 ENOG4105C26 Dehydrogenase H0910_RS02925 ENOG4108UAJ Transcriptional regulator H0910_RS02930 ENOG4105CUB amino acid H0910_RS02965 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) H0910_RS02975 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H0910_RS02980 ENOG4105EJC lysr family transcriptional regulator H0910_RS02985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0910_RS02990 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H0910_RS03005 ENOG4108NRW Phospholipase, patatin family H0910_RS03010 ENOG4105EYA deoxyribonuclease H0910_RS03015 ENOG4105D9N nucleoside H0910_RS03020 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) H0910_RS03025 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) H0910_RS03030 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) H0910_RS03040 ENOG4105WCN acetyltransferase H0910_RS03050 ENOG4107RAN Peptidase, M16 H0910_RS03055 ENOG4105CQ0 ABC transporter H0910_RS03060 ENOG4105PE1 Receptor H0910_RS03070 ENOG4108SF5 RNA Polymerase H0910_RS03080 ENOG41062Z9 Membrane H0910_RS03085 ENOG4105EAC phosphoserine phosphatase H0910_RS03090 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H0910_RS03095 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase H0910_RS03100 ENOG4105C5H ABC transporter H0910_RS03115 ENOG4107SC1 transglycosylase H0910_RS03120 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) H0910_RS03125 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H0910_RS03130 ENOG4105CVJ phosphoglycerate mutase H0910_RS03135 ENOG4105UEI Transcriptional Regulator AraC Family H0910_RS03140 ENOG4108RH0 Crea protein H0910_RS03150 ENOG41065U4 response regulator H0910_RS03165 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) H0910_RS03185 ENOG4105CPC Aldo Keto reductase H0910_RS03190 ENOG4105D1Q UPF0246 protein H0910_RS03195 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0910_RS03200 ENOG4108RIR Molybdenum cofactor biosynthesis protein H0910_RS03205 ENOG4106HK8 GPR1 FUN34 yaaH family protein H0910_RS03210 ENOG4105CFG Acts as a chaperone (By similarity) H0910_RS03215 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H0910_RS03220 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) H0910_RS03230 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0910_RS03235 ENOG41063Z6 transcriptional regulator, lysR family H0910_RS03240 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) H0910_RS03245 ENOG4105DTN riboflavin biosynthesis protein ribF H0910_RS03250 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H0910_RS03255 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) H0910_RS03260 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase H0910_RS03265 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H0910_RS03270 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H0910_RS03275 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H0910_RS03280 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H0910_RS03285 ENOG4107ZY0 Phenazine biosynthesis-like protein H0910_RS03290 ENOG4108K81 inner membrane protein YghB H0910_RS03295 ENOG4105C28 cystathionine H0910_RS03300 ENOG4105CWK Biopolymer transport protein, ExbB H0910_RS03305 ENOG4108ZZF transport protein (ExbD) H0910_RS03310 ENOG41066VF YeeE YedE family protein H0910_RS03325 ENOG4105DH7 May be involved in recombination (By similarity) H0910_RS03335 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic H0910_RS03350 ENOG4105EYH Exonuclease H0910_RS03355 ENOG4107RH8 nuclease SbcCD subunit D H0910_RS03360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0910_RS03365 ENOG4105BZU Histidine kinase H0910_RS03370 ENOG4105CWM branched-chain amino acid transport system II carrier protein H0910_RS03380 ENOG4105D3R alkyl hydroperoxide reductase H0910_RS03385 ENOG4108ZYK Acyl carrier protein phosphodiesterase H0910_RS03390 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H0910_RS03400 ENOG4105VIE preprotein translocase, subunit YajC H0910_RS03405 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0910_RS03410 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0910_RS03415 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) H0910_RS03420 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H0910_RS03425 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H0910_RS03430 ENOG4107YIM Involved in the transcription termination process (By similarity) H0910_RS03435 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H0910_RS03440 ENOG4108ZAI phosphatidylglycerophosphatase a H0910_RS03450 ENOG4108NAE Fimbrial chaperone protein H0910_RS03475 ENOG4108FZ9 Chaperone H0910_RS03480 ENOG4105CW0 outer membrane usher protein H0910_RS03490 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H0910_RS03495 ENOG4105CTB Polyprenyl synthetase H0910_RS03505 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) H0910_RS03510 ENOG4107S0N DJ-1 family H0910_RS03515 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H0910_RS03520 ENOG4108VPT UPF0234 protein H0910_RS03525 ENOG4107RDB Major Facilitator H0910_RS03530 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H0910_RS03535 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) H0910_RS03540 ENOG4105CCU oxidase (Subunit III) H0910_RS03545 ENOG4105BZ9 Cytochrome C oxidase, subunit I H0910_RS03550 ENOG4105E2S oxidase) subunit II H0910_RS03555 ENOG4108NFH Sugar hydrolase H0910_RS03560 ENOG4105EYM Major Facilitator superfamily H0910_RS03565 ENOG4105IEY (LipO)protein H0910_RS03570 ENOG4105M85 Bola protein H0910_RS03575 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H0910_RS03580 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H0910_RS03585 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H0910_RS03590 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H0910_RS03595 ENOG4105K70 DNA-binding protein H0910_RS03600 ENOG4105EIN peptidylprolyl cis-trans isomerase H0910_RS03605 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein H0910_RS03610 ENOG4108TGP Thioesterase superfamily protein H0910_RS03615 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) H0910_RS03620 ENOG4108XM1 transcriptional regulator AsnC family H0910_RS03625 ENOG4105BZ1 (ABC) transporter H0910_RS03630 ENOG4105BZ1 (ABC) transporter H0910_RS03635 ENOG4105C29 acyl-CoA thioesterase H0910_RS03650 ENOG4105KF5 hemolysin expression-modulating protein H0910_RS03655 ENOG4108UKR Biofilm formation regulator YbaJ H0910_RS03660 ENOG4105E9H Lytic Murein transglycosylase H0910_RS03665 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H0910_RS03670 ENOG4105D1A Methyltransferase H0910_RS03675 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0910_RS03680 ENOG4107RZZ dna polymerase iii epsilon subunit H0910_RS03710 ENOG4106H6R UPF0380 protein H0910_RS03715 ENOG4105MFG Antirestriction protein H0910_RS03720 ENOG4105TS0 gtp-binding protein H0910_RS03775 ENOG4105JXR Protein of unknown function (DUF3296) H0910_RS03790 ENOG410679B prophage CP4-57 regulatory protein alpA H0910_RS03800 ENOG4105DFP Integrase H0910_RS03840 ENOG4105CV1 Transketolase (EC 2.2.1.1) H0910_RS03845 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H0910_RS03850 ENOG4105BZA Phosphoglycerate kinase H0910_RS03855 ENOG4105D2N Aldolase H0910_RS03890 ENOG4106P2F Pfam:Pili_assembly_C H0910_RS03895 ENOG4106PG1 outer membrane usher protein H0910_RS03905 ENOG4105HMV Fimbrial protein H0910_RS03920 ENOG4107UWN reductase H0910_RS03925 ENOG4105EFA 4-hydroxyphenylacetate H0910_RS03950 ENOG4105C26 Dehydrogenase H0910_RS03955 ENOG4105C2C drug resistance transporter, Bcr CflA H0910_RS03965 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase H0910_RS03970 ENOG4105C26 Dehydrogenase H0910_RS03980 ENOG4105ERH Fumarylacetoacetate hydrolase H0910_RS03985 ENOG4108V8F Transcriptional regulator, MarR family H0910_RS03990 ENOG4105D5K Hemolysin activator protein H0910_RS04005 ENOG4105C94 Transporter H0910_RS04015 ENOG4105DIJ Phosphoethanolamine transferase H0910_RS04020 ENOG4107SVH Potassium channel protein H0910_RS04030 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) H0910_RS04035 ENOG4105K63 Thioredoxin H0910_RS04045 ENOG4105ETE Transcriptional regulator (LacI family H0910_RS04050 ENOG4105CNN ABC, transporter H0910_RS04055 ENOG4105C2J ABC transporter H0910_RS04060 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0910_RS04065 ENOG4105CPQ Dehydrogenase H0910_RS04105 ENOG4105E6S usher protein( H0910_RS04130 ENOG4105CW0 outer membrane usher protein H0910_RS04135 ENOG4108AF8 Chaperone H0910_RS04140 ENOG4108ZI2 Fimbrial protein H0910_RS04155 ENOG4105EJC lysr family transcriptional regulator H0910_RS04165 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H0910_RS04175 ENOG4105HX0 Transcriptional regulator H0910_RS04190 ENOG4105DU0 nucleoside hydrolase H0910_RS04200 ENOG4106H6R UPF0380 protein H0910_RS04205 ENOG4106549 Antirestriction protein H0910_RS04230 ENOG4108QDQ Ubiquinol-cytochrome C chaperone H0910_RS04270 ENOG4105CMR udp-glucose 4-epimerase H0910_RS04300 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H0910_RS04310 ENOG4105MFV ABC-2 type transporter H0910_RS04315 ENOG4105EY8 ABC transporter H0910_RS04385 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division H0910_RS04390 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) H0910_RS04395 ENOG4105CEN a g-specific adenine glycosylase H0910_RS04400 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H0910_RS04405 ENOG41090ED Protein with unknown function (DUF469) H0910_RS04410 ENOG4105CSV Glutaminase H0910_RS04415 ENOG4105K33 Periplasmic Protein H0910_RS04425 ENOG4105CSA Coproporphyrinogen iii oxidase H0910_RS04430 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H0910_RS04435 ENOG4108VIA integral membrane protein H0910_RS04440 ENOG4105II7 pyrroline-5-carboxylate reductase H0910_RS04445 ENOG4105DFA alanine racemase domain protein H0910_RS04450 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H0910_RS04455 ENOG4108UJU UPF0301 protein H0910_RS04460 ENOG4105D7Z glutathione synthase H0910_RS04465 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H0910_RS04470 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) H0910_RS04485 ENOG4105EJC lysr family transcriptional regulator H0910_RS04490 ENOG4105RQF LysR family Transcriptional regulator H0910_RS04505 ENOG4107QPN acyl-Coa dehydrogenase H0910_RS04510 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H0910_RS04515 ENOG4105E7A Glutamine amidotransferase H0910_RS04520 ENOG4105F7V ErfK ybiS ycfS ynhG family protein H0910_RS04525 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0910_RS04530 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0910_RS04535 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0910_RS04540 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0910_RS04545 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0910_RS04550 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) H0910_RS04555 ENOG4105CJ2 (LipO)protein H0910_RS04575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0910_RS04580 ENOG4105CIN aminoacyl-histidine dipeptidase H0910_RS04585 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) H0910_RS04590 ENOG4105V1F Fermentation respiration switch protein H0910_RS04595 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) H0910_RS04600 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H0910_RS04605 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) H0910_RS04610 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H0910_RS04615 ENOG4105CEY Amp-dependent synthetase and ligase H0910_RS04620 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) H0910_RS04625 ENOG4107TH8 cina domain protein H0910_RS04630 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H0910_RS04635 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H0910_RS04640 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H0910_RS04665 ENOG4105D9M gamma-glutamylcysteine synthetase H0910_RS04675 ENOG4108JU6 CBS domain protein H0910_RS04680 ENOG4106KVJ cytochrome C assembly protein H0910_RS04685 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H0910_RS04690 ENOG4105K5M 30s ribosomal protein S16 H0910_RS04700 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H0910_RS04705 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H0910_RS04710 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0910_RS04715 ENOG4105EHE chorismate mutase- prephenate dehydrogenase H0910_RS04720 ENOG4105C8Q Methyl-accepting chemotaxis H0910_RS04730 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA H0910_RS04735 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0910_RS04740 ENOG4105C34 Pseudouridine synthase H0910_RS04745 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H0910_RS04750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0910_RS04785 ENOG4105T42 (LipO)protein H0910_RS04790 ENOG4105JIM Phosphatidylserine synthase H0910_RS04795 ENOG4105CD5 CoA-binding domain protein H0910_RS04800 ENOG4106IUH DTW domain containing protein H0910_RS04805 ENOG4105EIB trna rrna methyltransferase H0910_RS04810 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0910_RS04815 ENOG4105CW7 secretion protein, HlyD family H0910_RS04820 ENOG4105NTK Transcriptional repressor Mpra H0910_RS04825 ENOG4105EQ0 Major Facilitator superfamily H0910_RS04830 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0910_RS04840 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) H0910_RS04850 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0910_RS04855 ENOG4105VEQ Cold shock protein H0910_RS04860 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H0910_RS04870 ENOG4108Z43 UPF0250 protein H0910_RS04875 ENOG4105DZ1 carboxypeptidase H0910_RS04880 ENOG4105K6T rare lipoprotein A H0910_RS04885 ENOG4105CNI cell division protein FtsW H0910_RS04890 ENOG4105CJN penicillin-binding protein H0910_RS04895 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H0910_RS04900 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H0910_RS04910 ENOG4105DJF DNA polymerase III, delta' subunit H0910_RS04915 ENOG4108U2H Rare lipoprotein B H0910_RS04920 ENOG4105C8T Leucyl-tRNA synthetase H0910_RS04925 ENOG4105CDA abc transporter atp-binding protein H0910_RS04930 ENOG4105DRP amino acid AbC transporter H0910_RS04935 ENOG4105EAD ABC transporter H0910_RS04940 ENOG4107RP9 extracellular solute-binding protein, family 3 H0910_RS04950 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0910_RS04955 ENOG4105K63 Thioredoxin H0910_RS04975 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H0910_RS04980 ENOG4108JU5 Magnesium and cobalt efflux protein H0910_RS04985 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H0910_RS04990 ENOG4105C9A Phoh family H0910_RS04995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H0910_RS05000 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0910_RS05005 ENOG4105KVH Transcriptional regulator H0910_RS05010 ENOG4108RCM Nitroreductase H0910_RS05015 ENOG4105CK2 sodium dicarboxylate symporter H0910_RS05050 ENOG4105E2R ROK family H0910_RS05055 ENOG4105CE4 GlcNAc 6-P deacetylase H0910_RS05060 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) H0910_RS05065 ENOG4105CI1 PTS System H0910_RS05080 ENOG4105CX6 glutaminyL-tRNA synthetase H0910_RS05090 ENOG4105E0K tonB-dependent siderophore receptor H0910_RS05095 ENOG4105M0Y H0910_RS05100 ENOG4105EEX Two component transcriptional regulator (Winged helix family H0910_RS05105 ENOG4105C08 Histidine kinase H0910_RS05110 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) H0910_RS05115 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H0910_RS05120 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H0910_RS05130 ENOG4105XIQ Protein of unknown function (DUF2517) H0910_RS05140 ENOG4107QNR UPF0135 protein H0910_RS05150 ENOG4105C2C drug resistance transporter, Bcr CflA H0910_RS05160 ENOG4105BZN citrate synthase H0910_RS05165 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit H0910_RS05170 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein H0910_RS05175 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H0910_RS05180 ENOG4105E33 succinate dehydrogenase H0910_RS05185 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H0910_RS05190 ENOG4105C7S Dehydrogenase H0910_RS05195 ENOG4105CMV Succinyl-CoA synthetase subunit beta H0910_RS05200 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H0910_RS05205 ENOG4105C4M (Ubiquinol oxidase) subunit I H0910_RS05210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0910_RS05225 ENOG4107YD3 Thioesterase H0910_RS05230 ENOG4105E02 MotA TolQ exbB proton channel H0910_RS05240 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA H0910_RS05245 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) H0910_RS05250 ENOG4105KCK Peptidoglycan-associated lipoprotein H0910_RS05255 ENOG4105UFD tol-pal system protein YbgF H0910_RS05290 ENOG4106Z1T Nicotinamide Mononucleotide Transporter H0910_RS05295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0910_RS05310 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H0910_RS05320 ENOG4105DKW ABC transporter H0910_RS05325 ENOG4105F4R Transcriptional regulator mode H0910_RS05345 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H0910_RS05350 ENOG4105E0C molybdate abc transporter H0910_RS05355 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) H0910_RS05360 ENOG4108K4B hydrolase H0910_RS05365 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H0910_RS05370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H0910_RS05375 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H0910_RS05385 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H0910_RS05395 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H0910_RS05400 ENOG4105CXY transporter H0910_RS05405 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC H0910_RS05415 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta H0910_RS05420 ENOG4105CHW UPF0052 protein H0910_RS05430 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H0910_RS05435 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H0910_RS05440 ENOG4105M00 molybdopterin converting factor, subunit 1 H0910_RS05445 ENOG4108ZAF Molybdopterin H0910_RS05450 ENOG4105HFZ Membrane H0910_RS05455 ENOG4107QWP ABC-2 type transporter H0910_RS05460 ENOG4107QWP ABC-2 type transporter H0910_RS05465 ENOG4105CJ1 ABC, transporter H0910_RS05470 ENOG4105D0S secretion protein (HlyD H0910_RS05475 ENOG4107MVR Transcriptional regulator H0910_RS05480 ENOG4105C1J atp-dependent rna helicase H0910_RS05485 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) H0910_RS05490 ENOG4105Y3U Transglycosylase-associated protein H0910_RS05495 ENOG4105KHC sulfurtransferase H0910_RS05505 ENOG4105DVT helicase H0910_RS05515 ENOG4107AQZ Membrane H0910_RS05520 ENOG4108URH decarboxylase H0910_RS05530 ENOG4105C5H ABC transporter H0910_RS05535 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H0910_RS05540 ENOG4105D06 uba thif-type nad fad binding protein H0910_RS05545 ENOG4105CVM Molybdenum cofactor synthesis domain protein H0910_RS05550 ENOG4105EUJ GTP cyclohydrolase i H0910_RS05555 ENOG4105DHF Membrane H0910_RS05560 ENOG4107GZ4 SanA protein H0910_RS05565 ENOG4107U91 Rhomboid family H0910_RS05570 ENOG4107R1I NAD-dependent malic enzyme H0910_RS05590 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) H0910_RS05595 ENOG41067MG lrgb family H0910_RS05600 ENOG4105VAW lrga family H0910_RS05605 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H0910_RS05610 ENOG4105D1F ATP-binding protein H0910_RS05620 ENOG4105D0M Protease HtpX homolog H0910_RS05625 ENOG4105DBI uridine monophosphokinase H0910_RS05630 ENOG4105DHP deoxycytidine triphosphate deaminase H0910_RS05635 ENOG4108GAE asmA family H0910_RS05645 ENOG4105EE5 Membrane protein terC H0910_RS05650 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H0910_RS05670 ENOG4108KXH Ybak prolyl-tRNA synthetase associated H0910_RS05675 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H0910_RS05680 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H0910_RS05685 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H0910_RS05690 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H0910_RS05695 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H0910_RS05700 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H0910_RS05705 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H0910_RS05710 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H0910_RS05715 ENOG4107SRH Nad-dependent epimerase dehydratase H0910_RS05720 ENOG4108TGY Glutathione S-transferase H0910_RS05725 ENOG4105DZ1 carboxypeptidase H0910_RS05735 ENOG4105EJQ L-serine dehydratase H0910_RS05740 ENOG4105C44 Serine transporter H0910_RS05745 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H0910_RS05750 ENOG41090BQ Glutaredoxin H0910_RS05755 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress H0910_RS05760 ENOG4108RMJ sensory transduction regulator H0910_RS05765 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) H0910_RS05780 ENOG4105DMR ABC, transporter H0910_RS05785 ENOG4105GBT ABC transporter H0910_RS05790 ENOG4106PMH Extracellular solute-binding protein family 3 H0910_RS05795 ENOG4105E5Z arginine transporter ATP-binding subunit H0910_RS05800 ENOG4105CGD Nad-dependent epimerase dehydratase H0910_RS05805 ENOG4105DWU Membrane H0910_RS05810 ENOG4105CPB ATP-dependent endonuclease of the OLD family H0910_RS05815 ENOG4105DJY efflux transporter, rnd family, mfp subunit H0910_RS05820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0910_RS05835 ENOG4105ES4 Nitrilase H0910_RS05840 ENOG4108FUF Transcriptional regulator, IclR family H0910_RS05850 ENOG4105VEQ Cold shock protein H0910_RS05855 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) H0910_RS05860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0910_RS05870 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) H0910_RS05875 ENOG4108JJ8 (ABC) transporter H0910_RS05880 ENOG4108JJ9 ABC, transporter H0910_RS05885 ENOG4108MAJ Membrane H0910_RS05890 ENOG4105C3M thioredoxin reductase H0910_RS05900 ENOG4105CNU cell division protein FtsK H0910_RS05905 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) H0910_RS05910 ENOG4105D1H recombination factor protein RarA H0910_RS05915 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H0910_RS05925 ENOG4105F1A Pyruvate formate-lyase H0910_RS05930 ENOG4105C6N Formate acetyltransferase H0910_RS05935 ENOG4105TMB Formate nitrite transporter H0910_RS05940 ENOG4105DDY UPF0142 protein ycaO H0910_RS05945 ENOG4105HDK L-asparaginase H0910_RS05955 ENOG41090R7 Ferric uptake H0910_RS05960 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) H0910_RS05965 ENOG4105NNH LexA regulated protein H0910_RS05975 ENOG4105C42 Type I secretion membrane fusion protein (HlyD H0910_RS05985 ENOG4105EV9 Alpha Beta Hydrolase H0910_RS05990 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) H0910_RS05995 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 H0910_RS06000 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H0910_RS06005 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H0910_RS06010 ENOG4105CAT Cytidine monophosphate kinase H0910_RS06015 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H0910_RS06020 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H0910_RS06025 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 H0910_RS06030 ENOG4105BZ1 (ABC) transporter H0910_RS06035 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H0910_RS06040 ENOG4105VEQ Cold shock protein H0910_RS06045 ENOG4105W49 UPF0434 protein H0910_RS06050 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) H0910_RS06055 ENOG4107S90 membrAne H0910_RS06060 ENOG4106371 Methyltransferase H0910_RS06065 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) H0910_RS06070 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) H0910_RS06075 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) H0910_RS06095 ENOG4105F0S class B acid phosphatase H0910_RS06100 ENOG4105DIT ErfK YbiS YcfS YnhG family protein H0910_RS06105 ENOG4105EAQ (twin-arginine translocation) pathway signal H0910_RS06110 ENOG4105C5X domain protein H0910_RS06130 ENOG4105CGF Aromatic amino acid aminotransferase H0910_RS06135 ENOG4105FCK Membrane H0910_RS06140 ENOG4105C5S asparaginyl-tRNA synthetase H0910_RS06145 ENOG4107RH7 Nicotinate phosphoribosyltransferase H0910_RS06150 ENOG4105CD8 aminopeptidase N H0910_RS06155 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H0910_RS06160 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) H0910_RS06165 ENOG4105QVC MOSC domain-containing protein H0910_RS06170 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H0910_RS06175 ENOG4105C5H ABC transporter H0910_RS06180 ENOG4105F1S paraquat-inducible protein a H0910_RS06185 ENOG4105DY2 Paraquat-inducible protein b H0910_RS06190 ENOG4108Q2G (LipO)protein H0910_RS06195 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) H0910_RS06200 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) H0910_RS06205 ENOG4105DAN ATP-dependent protease H0910_RS06220 ENOG4105UYK outer membrane protein a H0910_RS06225 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) H0910_RS06230 ENOG4108RZ1 DNA transformation protein H0910_RS06235 ENOG4105EM2 membrane H0910_RS06240 ENOG41088T4 Helicase IV H0910_RS06245 ENOG4108Z5K methylglyoxal synthase H0910_RS06250 ENOG4105K4P CoA-binding domain protein H0910_RS06255 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) H0910_RS06260 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 H0910_RS06265 ENOG4108Z0T Part of a sulfur-relay system (By similarity) H0910_RS06315 ENOG4105CV8 reductase H0910_RS06320 ENOG4105HEI LysR family (Transcriptional regulator H0910_RS06330 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0910_RS06335 ENOG4105F27 Major Facilitator H0910_RS06360 ENOG4105EWI Short-chain dehydrogenase reductase Sdr H0910_RS06370 ENOG4107RSM transcriptional regulator H0910_RS06375 ENOG41082BV acetyltransferase H0910_RS06390 ENOG4105MWK D-amino acid dehydrogenase, small subunit H0910_RS06410 ENOG41077A9 carbonic anhydrase H0910_RS06415 ENOG4105F4R Transcriptional regulator mode H0910_RS06425 ENOG4105NAE bifunctional deaminase-reductase domain protein H0910_RS06435 ENOG4105KK4 UPF0060 membrane protein H0910_RS06450 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0910_RS06455 ENOG4108MG3 formate dehydrogenase H0910_RS06475 ENOG4108RW8 Universal stress protein F H0910_RS06485 ENOG4105C44 Serine transporter H0910_RS06495 ENOG4105JAB phenazine biosynthesis protein, phzf family H0910_RS06500 ENOG4105DUX Transporter H0910_RS06505 ENOG4105C6X Major Facilitator H0910_RS06510 ENOG4105D1S lipid A biosynthesis H0910_RS06515 ENOG4108ZXC Two component transcriptional regulator, luxr family H0910_RS06520 ENOG4106AFQ Histidine kinase H0910_RS06525 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0910_RS06530 ENOG4106WHD Tetrathionate reductase H0910_RS06535 ENOG4105DB1 molybdopterin oxidoreductase H0910_RS06540 ENOG4105C72 UPF0176 protein H0910_RS06550 ENOG4105PVA Biofilm formation regulatory protein BssS H0910_RS06555 ENOG4105EKE dihydroorotase H0910_RS06575 ENOG4105GSJ Inner membrane protein ylaC H0910_RS06585 ENOG4105KT7 mgtC SapB transporter H0910_RS06590 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic H0910_RS06605 ENOG4108M9K flagella biosynthesis protein FliZ H0910_RS06610 ENOG4105C26 Dehydrogenase H0910_RS06615 ENOG4105CK7 Sodium proline symporter H0910_RS06620 ENOG4105C85 amino acid H0910_RS06635 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) H0910_RS06640 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region H0910_RS06645 ENOG4107RD7 Flagellar Motor Protein, MotA H0910_RS06650 ENOG4105ER2 Ompa motb domain protein H0910_RS06655 ENOG4105CBS Chea signal transduction histidine kinase H0910_RS06660 ENOG4108V3W Chemotaxis protein, CheW H0910_RS06665 ENOG4105C8Q Methyl-accepting chemotaxis H0910_RS06670 ENOG4105C8Q Methyl-accepting chemotaxis H0910_RS06675 ENOG4105BZU Histidine kinase H0910_RS06680 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) H0910_RS06685 ENOG4108VYJ response regulator receiver protein H0910_RS06690 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) H0910_RS06705 ENOG4105N1F Hnh endonuclease H0910_RS06710 ENOG4105D00 flagellar biosynthetic protein flhB H0910_RS06715 ENOG4105D7B Flagellar biosynthesis protein flha H0910_RS06720 ENOG4105QVD Flagella synthesis protein FlgN H0910_RS06725 ENOG4105M9M anti-sigma28 factor FlgM H0910_RS06730 ENOG4105CKS Flagella basal body P-ring formation protein flgA H0910_RS06735 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H0910_RS06740 ENOG4108ZC9 flagellar basal-body rod protein flgc H0910_RS06745 ENOG4105W00 Flagellar hook capping protein H0910_RS06750 ENOG4105BZE flagellar hook protein, FlgE H0910_RS06755 ENOG4108KPB Flagellar basal-body rod protein FlgF H0910_RS06760 ENOG4105CGA flagellar basal-body rod protein FlgG H0910_RS06765 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) H0910_RS06770 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) H0910_RS06775 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj H0910_RS06780 ENOG4105E1Q flagellar hook-associated protein H0910_RS06785 ENOG4105DTJ flagellar hook-associated protein H0910_RS06790 ENOG4105D19 Role in flagellar biosynthesis (By similarity) H0910_RS06795 ENOG4105VS8 Flagellar biosynthetic protein fliq H0910_RS06800 ENOG4105CN7 Flagellar biosynthetic protein FliP H0910_RS06810 ENOG4105DD5 Flagellar motor switch protein H0910_RS06815 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H0910_RS06820 ENOG4107ZI8 flagellar basal body-associated protein flil H0910_RS06825 ENOG4105WF4 Flagellar hook-length control protein H0910_RS06830 ENOG4105GSA Flagellar export protein flij H0910_RS06835 ENOG4108JIR Flagellum-specific ATP synthase H0910_RS06840 ENOG41090PJ Flagellar assembly protein H0910_RS06845 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H0910_RS06850 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) H0910_RS06855 ENOG4105VQ0 flagellar hook-basal body complex protein fliE H0910_RS06880 ENOG4108UQ5 membrane protein YcdZ H0910_RS06920 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H0910_RS06925 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) H0910_RS06930 ENOG4105MQ3 flagellar protein FliS H0910_RS06935 ENOG4105DTS flagellar hook-associated H0910_RS06945 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0910_RS06960 ENOG4105C94 Transporter H0910_RS06965 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) H0910_RS06970 ENOG4105C26 Dehydrogenase H0910_RS06975 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) H0910_RS06985 ENOG4105VF7 tolerance protein H0910_RS06990 ENOG4107QPK )-transporter H0910_RS07000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0910_RS07005 ENOG4105D4T Citrate transporter H0910_RS07010 ENOG4107RBI VanW family H0910_RS07025 ENOG4105C7F AcnD-accessory protein PrpF H0910_RS07030 ENOG4107QPK )-transporter H0910_RS07045 ENOG4105CHY citrate lyase, alpha H0910_RS07050 ENOG4105CI0 Citrate lyase H0910_RS07055 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) H0910_RS07060 ENOG4105DUA (citrate (pro-3S)-lyase ligase H0910_RS07065 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H0910_RS07070 ENOG4106YYS transcriptional regulatory protein H0910_RS07075 ENOG4108V06 Glutathione peroxidase H0910_RS07085 ENOG4105DUX Transporter H0910_RS07090 ENOG4105CBT Fructose-1,6-bisphosphatase H0910_RS07115 ENOG4108VY7 phosphate-starvation-inducible protein PsiE H0910_RS07120 ENOG4105CFC Transporter H0910_RS07125 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H0910_RS07130 ENOG4105WH1 Two component transcriptional regulator luxr family H0910_RS07135 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H0910_RS07140 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase H0910_RS07170 ENOG4105RKW reductase (By H0910_RS07185 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H0910_RS07195 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC H0910_RS07205 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia H0910_RS07210 ENOG4107P2S Transcriptional regulator H0910_RS07225 ENOG4105EF1 ribulokinase H0910_RS07240 ENOG4105C4B ABC transporter, permease H0910_RS07245 ENOG41083J0 (ABC) transporter H0910_RS07265 ENOG4105R71 cytoplasmic protein H0910_RS07270 ENOG4108IMY Transcriptional regulator H0910_RS07290 ENOG4105PI0 Ferredoxin H0910_RS07295 ENOG4108ETY sodium dicarboxylate symporter H0910_RS07300 ENOG4107K5X Membrane-bound metal-dependent hydrolase H0910_RS07305 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H0910_RS07310 ENOG4107PN8 YfeABCD locus regulator H0910_RS07320 ENOG4105CC5 ABC transporter H0910_RS07325 ENOG4105CC5 ABC transporter H0910_RS07330 ENOG4105DIK (ABC) transporter H0910_RS07335 ENOG4105DSE periplasmic solute binding protein H0910_RS07340 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division H0910_RS07345 ENOG41082NP Multiple antibiotic resistance H0910_RS07365 ENOG4105C22 threonyL-tRNA synthetase H0910_RS07370 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H0910_RS07375 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H0910_RS07380 ENOG41082NX 50s ribosomal protein l35 H0910_RS07385 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H0910_RS07395 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H0910_RS07400 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H0910_RS07405 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) H0910_RS07415 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) H0910_RS07420 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) H0910_RS07425 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0910_RS07430 ENOG4105CKK Glycosyl transferase, family 2 H0910_RS07435 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) H0910_RS07440 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) H0910_RS07445 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) H0910_RS07450 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) H0910_RS07455 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) H0910_RS07460 ENOG4108QBX (LipO)protein H0910_RS07530 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0910_RS07535 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) H0910_RS07540 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H0910_RS07550 ENOG4105IPI Membrane H0910_RS07555 ENOG4105CQB FAD linked oxidase domain protein H0910_RS07560 ENOG4105KA0 thioesterase Superfamily protein H0910_RS07565 ENOG4108Z4V iron-sulfur cluster assembly H0910_RS07570 ENOG4105DIW FeS assembly protein SUFB H0910_RS07575 ENOG4105C3K feS assembly ATPase SufC H0910_RS07580 ENOG4105JRK feS assembly protein SufD H0910_RS07585 ENOG4105C9B Cysteine desulfurase H0910_RS07590 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H0910_RS07595 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H0910_RS07600 ENOG4105KMX major outer membrane lipoprotein H0910_RS07605 ENOG4105CA9 Pyruvate kinase H0910_RS07625 ENOG4107QI1 Mate efflux family protein H0910_RS07630 ENOG4108R6K riboflavin synthase, subunit alpha H0910_RS07645 ENOG4105CZQ inner membrane transport protein YdhC H0910_RS07650 ENOG4105F52 Transcriptional regulator H0910_RS07655 ENOG4105ETE Transcriptional regulator (LacI family H0910_RS07665 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0910_RS07670 ENOG4105M2J Glutaredoxin H0910_RS07675 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) H0910_RS07680 ENOG4108UYE Lactoylglutathione lyase H0910_RS07685 ENOG4105XZD Fe-S protein H0910_RS07690 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) H0910_RS07695 ENOG4108XTF Outer Membrane Lipoprotein H0910_RS07700 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) H0910_RS07705 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) H0910_RS07710 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H0910_RS07715 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H0910_RS07720 ENOG4108K3A Glutathione S-transferase H0910_RS07725 ENOG4105NX3 Membrane H0910_RS07730 ENOG4108JQ2 peptide transport system atp-binding protein H0910_RS07735 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein H0910_RS07740 ENOG4108EU3 peptide transport system, permease H0910_RS07745 ENOG4108EKA peptide transport system, permease H0910_RS07750 ENOG4108HIY periplasmic H0910_RS07755 ENOG4105E51 psp operon transcriptional activator H0910_RS07760 ENOG41087YS Phage shock protein A H0910_RS07765 ENOG4105YYT phage shock protein B H0910_RS07770 ENOG4105FM1 phage shock protein C H0910_RS07775 ENOG4105CM6 amino acid regulated cytosolic protein H0910_RS07780 ENOG4106K28 UPF0283 membrane protein H0910_RS07800 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H0910_RS07805 ENOG4107QSI ABC, transporter H0910_RS07810 ENOG4107RX3 Mg2 transporter protein cora family protein H0910_RS07815 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) H0910_RS07825 ENOG4108ZNX Heat shock protein H0910_RS07830 ENOG4105R3P Inner membrane protein yagU H0910_RS07845 ENOG4105XXV Acid-resistance protein H0910_RS07850 ENOG4105XH3 H0910_RS07855 ENOG4105VEQ Cold shock protein H0910_RS07880 ENOG4108UY0 (LipO)protein H0910_RS07885 ENOG4108U51 Universal stress protein H0910_RS07895 ENOG4108RW8 Universal stress protein F H0910_RS07915 ENOG4105DWK Membrane H0910_RS07920 ENOG4107XM3 UPF0442 protein H0910_RS07925 ENOG4105RWS endonuclease I H0910_RS07930 ENOG4105D5M phosphate starvation-inducible protein H0910_RS07935 ENOG4105Q26 Siderophore-interacting protein H0910_RS07945 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0910_RS07950 ENOG4105C4M (Ubiquinol oxidase) subunit I H0910_RS07955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0910_RS07960 ENOG4105N14 lysine exporter protein LysE YggA H0910_RS07965 ENOG4105EW9 transcriptional regulator AsnC family H0910_RS07985 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding H0910_RS08020 ENOG4108J5G 6-phosphogluconate dehydrogenase H0910_RS08030 ENOG4107QNK )-transporter H0910_RS08035 ENOG4105C3G gtp-binding protein H0910_RS08040 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H0910_RS08045 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria H0910_RS08050 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H0910_RS08055 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H0910_RS08060 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) H0910_RS08065 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H0910_RS08070 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H0910_RS08075 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H0910_RS08080 ENOG41063JG Transcriptional regulator H0910_RS08085 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H0910_RS08090 ENOG4105N5T Radical SAM Protein H0910_RS08095 ENOG41082ND Uncharacterized protein yjcO H0910_RS08100 ENOG4105CHH sulfate transporter H0910_RS08110 ENOG41077RS Phosphatase H0910_RS08115 ENOG4105E8V Alpha Beta Hydrolase Fold protein H0910_RS08120 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase H0910_RS08135 ENOG4107QMZ Dehydrogenase H0910_RS08140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0910_RS08145 ENOG4105C26 Dehydrogenase H0910_RS08150 ENOG4105BZG amino acid carrier protein H0910_RS08160 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase H0910_RS08165 ENOG4107XHZ cytoplasmic chaperone TorD family protein H0910_RS08175 ENOG4105F3T (LipO)protein H0910_RS08180 ENOG4105EV4 Multidrug resistance protein mdtH H0910_RS08185 ENOG4105D9U N-acetyltransferase H0910_RS08190 ENOG4105CJR Integral membrane protein (MviN H0910_RS08195 ENOG4105BZU Histidine kinase H0910_RS08200 ENOG4108YZA Nitrogen regulatory protein pii H0910_RS08205 ENOG4105C75 arginyL-tRNA synthetase H0910_RS08210 ENOG4106ZCM YecM protein H0910_RS08215 ENOG4106N3A copper homeostasis protein cutc H0910_RS08225 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) H0910_RS08230 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) H0910_RS08235 ENOG4105WJG Glutathione H0910_RS08240 ENOG4105M6F mutator MutT protein H0910_RS08250 ENOG4105C9M aspartyl-trna synthetase H0910_RS08255 ENOG4108TIT dATP pyrophosphohydrolase H0910_RS08260 ENOG4105CDY transcriptional regulatory protein H0910_RS08265 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H0910_RS08270 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H0910_RS08275 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H0910_RS08285 ENOG4105FAV ABC, transporter H0910_RS08290 ENOG4105FDK ABC transporter H0910_RS08295 ENOG4105NXV High-affinity zinc uptake system protein H0910_RS08300 ENOG4105DR5 peptidase H0910_RS08305 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase H0910_RS08325 ENOG4105CW0 outer membrane usher protein H0910_RS08335 ENOG4105CA9 Pyruvate kinase H0910_RS08340 ENOG4106KNT transcriptional regulator H0910_RS08345 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H0910_RS08355 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H0910_RS08360 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) H0910_RS08365 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) H0910_RS08390 ENOG4105M4H endoribonuclease L-psp H0910_RS08395 ENOG4105DVT helicase H0910_RS08400 ENOG41072GX Peptidase M22 Glycoprotease H0910_RS08405 ENOG4105Y4Z Outer Membrane Lipoprotein H0910_RS08410 ENOG4105CEY Amp-dependent synthetase and ligase H0910_RS08435 ENOG4108DNJ Pfam:TonB H0910_RS08440 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) H0910_RS08445 ENOG4107QMS site-determining protein H0910_RS08450 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) H0910_RS08455 ENOG4105VNG YcgL domain-containing protein H0910_RS08460 ENOG4105CVE Lytic murein transglycosylase H0910_RS08465 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H0910_RS08470 ENOG4108ZZ3 UPF0260 protein H0910_RS08475 ENOG4108T1W Fimbrial subunit type 3 H0910_RS08500 ENOG4105E9S glutaredoxin 2 H0910_RS08510 ENOG4105C5I Dehydrogenase H0910_RS08520 ENOG4107H52 Dicarboxylate transport H0910_RS08525 ENOG410689M (LipO)protein H0910_RS08530 ENOG4105WXT Conserved Protein H0910_RS08535 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H0910_RS08540 ENOG4105CQ7 ATP-dependent helicase H0910_RS08550 ENOG4105D5Q Arginine ornithine antiporter H0910_RS08555 ENOG4105C5D exported protein H0910_RS08560 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0910_RS08565 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0910_RS08570 ENOG4105Q9Y Universal stress protein H0910_RS08575 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H0910_RS08590 ENOG4105E0U tyrosine-specific transport protein H0910_RS08605 ENOG4105C5H ABC transporter H0910_RS08615 ENOG4105D0S secretion protein (HlyD H0910_RS08620 ENOG4105CJ1 ABC, transporter H0910_RS08625 ENOG4105CMI transporter H0910_RS08630 ENOG4105D3R alkyl hydroperoxide reductase H0910_RS08635 ENOG4108JU3 Alkyl hydroperoxide reductase H0910_RS08640 ENOG4107S01 Repressor protein MetJ H0910_RS08670 ENOG4105FYV Amp nucleosidase H0910_RS08680 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H0910_RS08690 ENOG4108W15 Protein of unknown function (DUF1456) H0910_RS08705 ENOG4108NIW Leucine export protein LeuE H0910_RS08745 ENOG4105CPF Cell wall formation (By similarity) H0910_RS08765 ENOG4105V0I UPF0267 protein H0910_RS08775 ENOG4108PCN EamA-like transporter family H0910_RS08780 ENOG4105K6H D-cysteine desulfhydrase H0910_RS08795 ENOG4105EQD regulatoR H0910_RS08800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0910_RS08805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0910_RS08810 ENOG4105E5W Transporter H0910_RS08815 ENOG4108I6A alcohol dehydrogenase H0910_RS08860 ENOG4105KKX ATPase associated with various cellular activities aaa_5 H0910_RS08870 ENOG4108ZT1 Transcriptional regulator H0910_RS08875 ENOG4108KTG Membrane protein, drug metabolite transporter H0910_RS08880 ENOG4105CF1 Alkylated DNA repair protein H0910_RS08890 ENOG4108UPT UPF0178 protein H0910_RS08895 ENOG4105E82 cytochrome subunit of dehydrogenase H0910_RS08905 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) H0910_RS08915 ENOG4106032 Glutathionylspermidine synthase H0910_RS08920 ENOG4105FCK Membrane H0910_RS08945 ENOG4105DXI Major Facilitator superfamily H0910_RS08965 ENOG4105VYA Uncharacterized conserved protein (DUF2132) H0910_RS08970 ENOG4105EZE Cupin 4 family protein H0910_RS08980 ENOG4107ZUJ lipid metabolic process H0910_RS08985 ENOG4105EMU Dehydrogenase H0910_RS08995 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H0910_RS09000 ENOG4105DAG ROK family H0910_RS09005 ENOG4106NZI LysR family Transcriptional regulator H0910_RS09010 ENOG4105D94 Major Facilitator Superfamily H0910_RS09015 ENOG4108M1A Chitin-binding protein H0910_RS09020 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) H0910_RS09025 ENOG4105C9Q fumarate hydratase class II H0910_RS09030 ENOG4105EIP mannose-6-phosphate isomerase H0910_RS09035 ENOG4106J39 exported protein H0910_RS09040 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) H0910_RS09045 ENOG4105DHU Bile acid H0910_RS09050 ENOG4105D9R oxidoreductase H0910_RS09055 ENOG4105M9B inner membrane protein ydgK H0910_RS09060 ENOG4105DGN Electron transport complex H0910_RS09070 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) H0910_RS09075 ENOG4105D6A Electron transport complex H0910_RS09080 ENOG4108UQQ Electron transport complex H0910_RS09090 ENOG4105CSM endonuclease III H0910_RS09095 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) H0910_RS09100 ENOG41061RM osmotically inducible lipoprotein H0910_RS09105 ENOG4108ZJT translation initiation factor, Sui1 H0910_RS09110 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) H0910_RS09115 ENOG4105CFV Tetratricopeptide repeat protein H0910_RS09120 ENOG4105Q4A inner membrane protein yciS H0910_RS09125 ENOG4105EYK Phosphatidylglycerophosphatase B H0910_RS09130 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) H0910_RS09135 ENOG4105D52 delta-aminolevulinic acid dehydratase H0910_RS09145 ENOG4107QM5 aconitate hydratase H0910_RS09150 ENOG4107R11 Transcriptional regulator H0910_RS09155 ENOG4105C9K Endothelin-converting enzyme 1 H0910_RS09165 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0910_RS09170 ENOG4105RKX Protein of unknown function (DUF2498) H0910_RS09175 ENOG4105ERU peptidase H0910_RS09180 ENOG4105UBK short-chain dehydrogenase reductase H0910_RS09185 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H0910_RS09195 ENOG4105FE9 pseudouridine synthase H0910_RS09200 ENOG4107RTD sua5 ycio yrdc ywlc family protein H0910_RS09205 ENOG4105DB7 PHP domain protein H0910_RS09210 ENOG4105CRQ synthase (Component I) H0910_RS09220 ENOG4108EFP Anthranilate synthase component II H0910_RS09225 ENOG4105DK0 Indole-3-glycerol phosphate synthase H0910_RS09230 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H0910_RS09235 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H0910_RS09240 ENOG4105EIF outer membrane protein W H0910_RS09245 ENOG4108S3I UPF0259 membrane protein H0910_RS09255 ENOG4107835 probably involved in intracellular septation (By similarity) H0910_RS09260 ENOG4105NAU thioesterase Superfamily protein H0910_RS09275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H0910_RS09280 ENOG4108W5H UPF0263 protein H0910_RS09290 ENOG4108JQ7 (ABC) transporter H0910_RS09295 ENOG4105C3U ABC transporter H0910_RS09300 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0910_RS09305 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0910_RS09310 ENOG4107QSI ABC, transporter H0910_RS09315 ENOG4107QSI ABC, transporter H0910_RS09320 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H0910_RS09325 ENOG4105C0A alcohol dehydrogenase H0910_RS09330 ENOG4108NAE Fimbrial chaperone protein H0910_RS09335 ENOG4107104 thymidine kinase H0910_RS09345 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H0910_RS09350 ENOG4105I93 response regulator H0910_RS09355 ENOG4105K5B UPF0225 protein H0910_RS09360 ENOG4105CIY formyltetrahydrofolate deformylase H0910_RS09375 ENOG4105CGK Exodeoxyribonuclease III H0910_RS09385 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0910_RS09390 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H0910_RS09395 ENOG41069NU Nitroreductase H0910_RS09400 ENOG4105D07 Signal peptide peptidase, SppA H0910_RS09405 ENOG4105HDK L-asparaginase H0910_RS09410 ENOG4108RWI nicotinamidase H0910_RS09415 ENOG4105VUT cytoplasmic protein H0910_RS09430 ENOG4105DSB aldose 1-epimerase H0910_RS09435 ENOG4105GNX MltA-interacting MipA family protein H0910_RS09440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0910_RS09445 ENOG4105MWK D-amino acid dehydrogenase, small subunit H0910_RS09450 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) H0910_RS09455 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0910_RS09460 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H0910_RS09475 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) H0910_RS09480 ENOG4105XVG cytoplasmic protein H0910_RS09495 ENOG4105D0M Protease HtpX homolog H0910_RS09505 ENOG4105CN1 protease H0910_RS09510 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) H0910_RS09515 ENOG4108ZGC gaf domain protein H0910_RS09520 ENOG4105H2K paraquat-inducible protein a H0910_RS09525 ENOG4105DY2 Paraquat-inducible protein b H0910_RS09530 ENOG4105WT8 Protein of unknown function (DUF1480) H0910_RS09535 ENOG4105NKT exported protein H0910_RS09540 ENOG4108PNC copper resistance H0910_RS09545 ENOG4105FXM Copper resistance protein H0910_RS09550 ENOG41090A1 ferritin H0910_RS09555 ENOG4105MPK DNA polymerase III subunit theta H0910_RS09560 ENOG4105VBS Inherit from NOG: Secreted protein H0910_RS09565 ENOG4105X5C UPF0181 protein H0910_RS09575 ENOG4105P8F nudix hydrolase H0910_RS09580 ENOG4105EJQ L-serine dehydratase H0910_RS09585 ENOG4105DAS pts system H0910_RS09590 ENOG4105ETZ PTS System H0910_RS09595 ENOG4105F3R pts system mannose fructose sorbose family iid H0910_RS09600 ENOG4108NK4 UPF0266 membrane protein H0910_RS09605 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) H0910_RS09610 ENOG4105DHI Methyltransferase H0910_RS09625 ENOG4107SSZ Phosphatase H0910_RS09630 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0910_RS09645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H0910_RS09650 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H0910_RS09655 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H0910_RS09680 ENOG4105CUG Oligopeptidase b H0910_RS09695 ENOG4105C6K Malic enzyme H0910_RS09700 ENOG4105WH1 Two component transcriptional regulator luxr family H0910_RS09705 ENOG4105KUZ arsenate reductase H0910_RS09710 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) H0910_RS09720 ENOG4105WD1 Membrane H0910_RS09725 ENOG4105XYK UPF0370 protein H0910_RS09730 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) H0910_RS09735 ENOG4108VMM UPF0756 membrane protein H0910_RS09755 ENOG4108JJB ABC transporter H0910_RS09765 ENOG4105C8V SAICAR synthetase H0910_RS09775 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0910_RS09785 ENOG4105RH4 Glycine cleavage system transcriptional repressor H0910_RS09790 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0910_RS09795 ENOG4105C02 permease H0910_RS09800 ENOG4105ERG peptidase m48, ste24p H0910_RS09805 ENOG4105K89 arsenate reductase H0910_RS09810 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) H0910_RS09815 ENOG4105C2W permease H0910_RS09820 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H0910_RS09825 ENOG4105CXB phosphoribosylaminoimidazole synthetase H0910_RS09830 ENOG4108V3E phosphoribosylglycinamide formyltransferase H0910_RS09840 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) H0910_RS09850 ENOG41090JH (ATPase)-like protein H0910_RS09855 ENOG4108MK9 spermidine N(1)-acetyltransferase H0910_RS09860 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H0910_RS09865 ENOG4105C9X ppx gppa phosphatase H0910_RS09870 ENOG4105CJW magnesium transporter H0910_RS09875 ENOG4105CSH Transporter H0910_RS09890 ENOG4105BZS acriflavin resistance protein H0910_RS09895 ENOG4105BZS acriflavin resistance protein H0910_RS09900 ENOG4105EB3 Histidine kinase H0910_RS09905 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0910_RS09910 ENOG4105CFP Peptidase U32 H0910_RS09915 ENOG4105DWF phosphomethylpyrimidine kinase H0910_RS09920 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) H0910_RS09925 ENOG4105C85 amino acid H0910_RS09940 ENOG410667J hydrolase H0910_RS09945 ENOG4105CWM branched-chain amino acid transport system II carrier protein H0910_RS09970 ENOG4105BZG amino acid carrier protein H0910_RS09995 ENOG4105CIH Imidazole acetol-phosphate transaminase H0910_RS10005 ENOG4108I0C methyltransferase H0910_RS10015 ENOG4105RA2 Membrane H0910_RS10030 ENOG4105KAF membrAne H0910_RS10040 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H0910_RS10045 ENOG4105CHJ isochorismatase hydrolase H0910_RS10155 ENOG4105EFC phage portal protein HK97 family H0910_RS10200 ENOG4105KUS lysozyme H0910_RS10225 ENOG41060V2 Acid-resistance protein H0910_RS10235 ENOG4108MXB Protein of unknown function (DUF968) H0910_RS10295 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H0910_RS10325 ENOG4108I1J Integrase H0910_RS10335 ENOG4108HMX isocitrate dehydrogenase (NADP) H0910_RS10340 ENOG4108R99 pseudouridine synthase H0910_RS10350 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H0910_RS10355 ENOG41075W9 High frequency lysogenization protein HflD homolog H0910_RS10360 ENOG4107QTF adenylosuccinate lyase H0910_RS10365 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0910_RS10375 ENOG4105EZE Cupin 4 family protein H0910_RS10395 ENOG4108TEB UPF0114 protein H0910_RS10405 ENOG4108IND Tetr family transcriptional regulator H0910_RS10420 ENOG4105D60 lipoprotein releasing system transmembrane protein H0910_RS10425 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H0910_RS10430 ENOG4105D60 lipoprotein releasing system transmembrane protein H0910_RS10435 ENOG4108JA2 transcriptioN-repair coupling factor H0910_RS10450 ENOG4105CEP NADH dehydrogenase H0910_RS10455 ENOG4105CGH 5'-nucleotidase H0910_RS10465 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) H0910_RS10475 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) H0910_RS10480 ENOG41090DQ Lipoprotein H0910_RS10485 ENOG4105K59 histidine triad (HIT) protein H0910_RS10490 ENOG4105F8V Hydrolase, tatD family H0910_RS10495 ENOG4107QRG dna polymerase iii H0910_RS10500 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) H0910_RS10505 ENOG4105HHA aminodeoxychorismate lyase H0910_RS10510 ENOG4105YAZ 4-amino-4-deoxychorismate lyase H0910_RS10515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0910_RS10520 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H0910_RS10525 ENOG4105CHR reductase H0910_RS10530 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H0910_RS10535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0910_RS10540 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) H0910_RS10545 ENOG4105VGS 50s ribosomal protein l32 H0910_RS10550 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H0910_RS10555 ENOG4108UHJ MAF-like protein H0910_RS10560 ENOG4105EI2 Pseudouridine synthase H0910_RS10565 ENOG4107QQB Ribonuclease E H0910_RS10570 ENOG41090HJ UPF0265 protein H0910_RS10575 ENOG4105CJB Exodeoxyribonuclease I H0910_RS10580 ENOG4105CXG d-lactate dehydrogenase H0910_RS10585 ENOG4105CUB amino acid H0910_RS10595 ENOG4105D05 Receptor H0910_RS10600 ENOG4108IQI permease H0910_RS10605 ENOG4105DUM transcriptional regulator, lysR family H0910_RS10610 ENOG4105HMI Membrane H0910_RS10615 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) H0910_RS10620 ENOG4105DE4 1-phosphofructokinase H0910_RS10635 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H0910_RS10645 ENOG4107TT5 NLP P60 protein H0910_RS10650 ENOG4105HG6 H0910_RS10655 ENOG4105C2C drug resistance transporter, Bcr CflA H0910_RS10660 ENOG4105I08 Pseudouridine synthase H0910_RS10665 ENOG4105CFI type iii restriction protein res subunit H0910_RS10670 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H0910_RS10675 ENOG4106V8H Nucleoid-associated protein H0910_RS10680 ENOG4105PAN UPF0352 protein H0910_RS10685 ENOG4105E68 Sulfatase H0910_RS10720 ENOG4105CDV Ompa motb domain protein H0910_RS10730 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0910_RS10820 ENOG4105D3W isochorismatase H0910_RS10830 ENOG4105CUY Mechanosensitive ion channel H0910_RS10835 ENOG4107QY8 reductase H0910_RS10840 ENOG4105QAX Iron-sulfur H0910_RS10845 ENOG4107KGK dmso reductase anchor subunit H0910_RS10850 ENOG4108NEM leader-binding protein dmsD H0910_RS10865 ENOG4108JIK carboxylase H0910_RS10870 ENOG4105P4J Allophanate hydrolase, subunit 1 H0910_RS10880 ENOG4105E7W lamb ycsf family protein H0910_RS10885 ENOG4105C5A transporter H0910_RS10895 ENOG4105CK2 sodium dicarboxylate symporter H0910_RS10905 ENOG4108I6E Sulfatase H0910_RS10920 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC H0910_RS10925 ENOG41068CG regulatoR H0910_RS10930 ENOG4105BZU Histidine kinase H0910_RS10935 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0910_RS10940 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H0910_RS10945 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0910_RS10950 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0910_RS10955 ENOG4105XPH Ferredoxin H0910_RS10960 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H0910_RS10965 ENOG4105E0U tyrosine-specific transport protein H0910_RS10970 ENOG4108UII YfaZ family H0910_RS10975 ENOG4105CH6 catalase H0910_RS10980 ENOG4105CEY Amp-dependent synthetase and ligase H0910_RS10985 ENOG4105DNI Converts SHCHC to OSB (By similarity) H0910_RS10990 ENOG4108IPT Naphthoate synthase H0910_RS11000 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) H0910_RS11005 ENOG4105E4F Isochorismate synthase H0910_RS11020 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0910_RS11025 ENOG4105C8S subunit m H0910_RS11030 ENOG4105D65 subunit l H0910_RS11040 ENOG4107UFS subunit j H0910_RS11045 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0910_RS11050 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H0910_RS11055 ENOG4108IEH NADH dehydrogenase subunit g H0910_RS11060 ENOG4107QIZ NADH dehydrogenase H0910_RS11065 ENOG4105GKE subunit e H0910_RS11070 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0910_RS11075 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0910_RS11080 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H0910_RS11085 ENOG4107NQ8 LysR family Transcriptional regulator H0910_RS11090 ENOG4105CHM Aminotransferase H0910_RS11100 ENOG4105DK2 UPF0207 protein H0910_RS11115 ENOG4107QWE )-transporter H0910_RS11120 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 H0910_RS11125 ENOG4105XWI UPF0304 protein H0910_RS11130 ENOG4105PQ6 UPF0208 membrane protein H0910_RS11135 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H0910_RS11140 ENOG4105C6K Malic enzyme H0910_RS11150 ENOG4105PTV Nudix Hydrolase H0910_RS11155 ENOG4105ECP epimerase H0910_RS11160 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H0910_RS11165 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H0910_RS11170 ENOG4105E96 Colicin v production protein H0910_RS11175 ENOG4108S3P Sporulation domain protein H0910_RS11180 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H0910_RS11185 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) H0910_RS11190 ENOG4105DQR SNARE associated Golgi H0910_RS11195 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H0910_RS11200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0910_RS11205 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) H0910_RS11225 ENOG4105DHQ Histidine kinase H0910_RS11270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0910_RS11275 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) H0910_RS11280 ENOG4105XYF acetyltransferase H0910_RS11285 ENOG4105MH2 YfcL protein H0910_RS11290 ENOG4108BPE -transporting atpase H0910_RS11295 ENOG4105EJ9 Membrane H0910_RS11300 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H0910_RS11305 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H0910_RS11310 ENOG4105C85 amino acid H0910_RS11315 ENOG4105C84 Histidine ammonia-lyase H0910_RS11330 ENOG4105CI2 imidazolone-5-propionate hydrolase H0910_RS11335 ENOG4108DG9 Smr protein MutS2 H0910_RS11340 ENOG4108BY2 phosphohistidine phosphatase H0910_RS11345 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H0910_RS11350 ENOG4105CHU acetyl-coa acetyltransferase H0910_RS11355 ENOG4105KZW UPF0381 protein H0910_RS11360 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation H0910_RS11365 ENOG410903C (LipO)protein H0910_RS11395 ENOG4105D01 (LipO)protein H0910_RS11405 ENOG4105E1J oxidoreductase H0910_RS11410 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0910_RS11415 ENOG4108UMI ABC transporter, permease H0910_RS11425 ENOG4105ZUU Transcriptional regulator H0910_RS11460 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H0910_RS11480 ENOG4105VRT cytoplasmic protein H0910_RS11485 ENOG4105D9N nucleoside H0910_RS11490 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H0910_RS11495 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) H0910_RS11500 ENOG4105EXN Sulfate transport protein CysZ H0910_RS11505 ENOG4105C6T cysteine synthase H0910_RS11515 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0910_RS11520 ENOG4105C5Y PTS System H0910_RS11525 ENOG4105C6T cysteine synthase H0910_RS11530 ENOG4108IJ6 ABC transporter H0910_RS11535 ENOG4105ECW sulfate abc transporter H0910_RS11540 ENOG4108I5D sulfate abc transporter H0910_RS11545 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein H0910_RS11550 ENOG4105EZR dyp-type peroxidase family protein H0910_RS11560 ENOG4108R6G acetyltransferase H0910_RS11565 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) H0910_RS11575 ENOG4105FE9 pseudouridine synthase H0910_RS11585 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0910_RS11590 ENOG4105N21 Membrane H0910_RS11595 ENOG4105CUT histidyl-tRNA synthetase H0910_RS11600 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H0910_RS11610 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H0910_RS11615 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H0910_RS11620 ENOG4108JQB penicillin-binding protein 1C H0910_RS11625 ENOG4105DN3 alpha-2-macroglobulin domain protein H0910_RS11630 ENOG4105YYA enhanced serine sensitivity protein SseB H0910_RS11635 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H0910_RS11640 ENOG4105WVQ Fe-S assembly protein IscX H0910_RS11645 ENOG4108ZIT Ferredoxin, 2FE-2S H0910_RS11650 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB H0910_RS11655 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) H0910_RS11660 ENOG4108Z4V iron-sulfur cluster assembly H0910_RS11665 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H0910_RS11670 ENOG4105C3J Cysteine desulfurase H0910_RS11675 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family H0910_RS11680 ENOG4105CVS RNA methyltransferase TrmH family, group 1 H0910_RS11685 ENOG4105ECY inositol monophosphatase H0910_RS11690 ENOG4105D8G Major Facilitator superfamily H0910_RS11695 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H0910_RS11700 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0910_RS11710 ENOG4105C4K Nad synthetase H0910_RS11715 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0910_RS11720 ENOG4108SKK alpha helix protein H0910_RS11725 ENOG4107WP9 Histidine kinase H0910_RS11735 ENOG4108KX4 response regulator H0910_RS11740 ENOG4105BZU Histidine kinase H0910_RS11745 ENOG4105CXY transporter H0910_RS11750 ENOG4105C4Y ABC transporter H0910_RS11755 ENOG4107RCV ABC transporter, permease H0910_RS11760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0910_RS11765 ENOG4107QIK phosphoribosylformylglycinamidine synthase H0910_RS11775 ENOG4108Z6B deaminase H0910_RS11780 ENOG4108NIW Leucine export protein LeuE H0910_RS11790 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H0910_RS11795 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) H0910_RS11800 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) H0910_RS11815 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H0910_RS11820 ENOG4105C3F Signal peptidase i H0910_RS11825 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H0910_RS11830 ENOG4105WMJ Positive regulator of sigma E, RseC MucC H0910_RS11850 ENOG4108IYU L-aspartate oxidase H0910_RS11855 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) H0910_RS11865 ENOG41088SP formiminoglutamate hydrolase H0910_RS11870 ENOG4105D6U Sodium Glutamate Symporter H0910_RS11875 ENOG4105C1J atp-dependent rna helicase H0910_RS11890 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H0910_RS11895 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H0910_RS11900 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H0910_RS11905 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H0910_RS11910 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0910_RS11915 ENOG4105VDB UPF0125 protein H0910_RS11920 ENOG4108Z1B Cyclase dehydrase H0910_RS11925 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H0910_RS11945 ENOG4105C7F AcnD-accessory protein PrpF H0910_RS11950 ENOG4105F04 LysR family Transcriptional regulator H0910_RS11970 ENOG4105W5Q DNA repair protein (RadC H0910_RS11995 ENOG4105DFP Integrase H0910_RS12015 ENOG4108BUD transposase H0910_RS12090 ENOG4108ZHR arsR family transcriptional regulator H0910_RS12105 ENOG4105D6U Sodium Glutamate Symporter H0910_RS12130 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H0910_RS12135 ENOG4105D44 asparaginase H0910_RS12140 ENOG4105DZC cytosine deaminase H0910_RS12145 ENOG4105C5B carbamate kinase H0910_RS12155 ENOG4107REC cytoplasmic protein H0910_RS12160 ENOG4107R1Q Membrane protein FdrA H0910_RS12165 ENOG4105N16 Protein of unknown function (DUF2877) H0910_RS12170 ENOG4107SNB ankyrin repeat protein YahD H0910_RS12175 ENOG4108NUU Transcriptional regulator H0910_RS12185 ENOG4105DJ2 Major Facilitator Superfamily H0910_RS12195 ENOG4105HEI LysR family (Transcriptional regulator H0910_RS12200 ENOG4107F3C Hemin uptake protein H0910_RS12205 ENOG4107ENK receptor H0910_RS12210 ENOG4106QJH hemin transport protein H0910_RS12215 ENOG4107R4I Periplasmic binding protein H0910_RS12220 ENOG4105EHG Permease protein H0910_RS12230 ENOG4105FFC UPF0187 protein H0910_RS12240 ENOG4108ISG Major Facilitator H0910_RS12245 ENOG4108JU7 Transcriptional regulator H0910_RS12250 ENOG4105CR4 methylisocitrate lyase H0910_RS12255 ENOG4105BZN citrate synthase H0910_RS12260 ENOG4105DXD 2-methylcitrate dehydratase H0910_RS12265 ENOG4105C1J atp-dependent rna helicase H0910_RS12270 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H0910_RS12275 ENOG41076HS cation diffusion facilitator family transporter H0910_RS12280 ENOG4108RW8 Universal stress protein F H0910_RS12285 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) H0910_RS12295 ENOG4105VXR cytoplasmic protein H0910_RS12300 ENOG4108KB1 transcriptional regulator, arac family H0910_RS12305 ENOG410801I Peptidyl-prolyl cis-trans isomerase H0910_RS12315 ENOG4105CRK lysyL-tRNA synthetase H0910_RS12325 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H0910_RS12330 ENOG4105T95 Thiol disulfide interChange protein H0910_RS12335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0910_RS12340 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) H0910_RS12345 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB H0910_RS12350 ENOG4105Y75 tpr repeat protein H0910_RS12355 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) H0910_RS12365 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor H0910_RS12370 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) H0910_RS12375 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H0910_RS12380 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0910_RS12385 ENOG4105D0A hydroxylase H0910_RS12390 ENOG4107RAQ aminopeptidase H0910_RS12395 ENOG4105E07 UPF0149 protein H0910_RS12400 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) H0910_RS12410 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H0910_RS12415 ENOG4108JQ1 Dehydrogenase H0910_RS12420 ENOG4105E66 phosphoriboisomerase A H0910_RS12425 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) H0910_RS12430 ENOG4105MPN Membrane H0910_RS12435 ENOG4108ZUB Lysine exporter protein (Lyse ygga) H0910_RS12440 ENOG4105D64 Mechanosensitive ion channel H0910_RS12445 ENOG4108ZIG UPF0231 protein H0910_RS12450 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase H0910_RS12455 ENOG4107QIJ Aconitate hydratase 2 H0910_RS12475 ENOG4107QN2 dihydrolipoyl dehydrogenase H0910_RS12480 ENOG4107QSN dihydrolipoamide acetyltransferase H0910_RS12485 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H0910_RS12490 ENOG41073TP transcriptional regulator H0910_RS12495 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0910_RS12500 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H0910_RS12505 ENOG4108ZUW Major pilin subunit H0910_RS12510 ENOG4107QHF type ii secretion system protein e H0910_RS12520 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H0910_RS12525 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) H0910_RS12535 ENOG4105M6F mutator MutT protein H0910_RS12540 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H0910_RS12545 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) H0910_RS12555 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0910_RS12560 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H0910_RS12565 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H0910_RS12570 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H0910_RS12575 ENOG4105CPF Cell wall formation (By similarity) H0910_RS12580 ENOG4105DFU Cell wall formation (By similarity) H0910_RS12585 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H0910_RS12590 ENOG4105CNI cell division protein FtsW H0910_RS12595 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H0910_RS12600 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H0910_RS12605 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H0910_RS12610 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H0910_RS12615 ENOG4105CJN penicillin-binding protein H0910_RS12620 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H0910_RS12625 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H0910_RS12630 ENOG4108V6E Cell division protein mraZ H0910_RS12635 ENOG4107B7Y DNA-binding transcriptional regulator FruR H0910_RS12640 ENOG4108ZP8 Acetolactate synthase small subunit H0910_RS12645 ENOG4105C7K acetolactate synthase H0910_RS12650 ENOG4108IQE Amp-dependent synthetase and ligase H0910_RS12655 ENOG41064T2 transcriptional regulator, lysR family H0910_RS12665 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0910_RS12670 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H0910_RS12680 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) H0910_RS12685 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) H0910_RS12690 ENOG4105EE5 Membrane protein terC H0910_RS12705 ENOG4105CYW agmatinase H0910_RS12710 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) H0910_RS12715 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H0910_RS12730 ENOG41080HT Transcriptional regulator, arsr family H0910_RS12735 ENOG4105GPY SprT protein H0910_RS12740 ENOG4105CJW magnesium transporter H0910_RS12745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0910_RS12750 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) H0910_RS12765 ENOG4107QHE Choloylglycine hydrolase H0910_RS12775 ENOG4108YYC ycei family H0910_RS12780 ENOG4105DS1 cytochrome b561 H0910_RS12810 ENOG4108RYK Nad-dependent epimerase dehydratase H0910_RS12820 ENOG4105UEI Transcriptional Regulator AraC Family H0910_RS12835 ENOG4105KWW Biogenesis protein H0910_RS12840 ENOG4107QX9 Thiol disulfide interChange protein H0910_RS12845 ENOG4105DA4 cytochrome c-type biogenesis protein H0910_RS12855 ENOG4105X3C heme exporter protein H0910_RS12860 ENOG41060IM Heme exporter protein H0910_RS12865 ENOG4105CUW cytochrome C-TYPE protein H0910_RS12870 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) H0910_RS12875 ENOG4105GXZ Ferredoxin-type protein NapH H0910_RS12880 ENOG4108BGM Quinol dehydrogenase periplasmic component H0910_RS12890 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase H0910_RS12895 ENOG4108ZNS ferredoxin-type protein NapF H0910_RS12900 ENOG4105EAU Plays a role in nitrite reduction (By similarity) H0910_RS12905 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit H0910_RS12910 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0910_RS12915 ENOG4105DVI reductase, NrfD H0910_RS12920 ENOG4108QKW cytochrome c-type biogenesis protein H0910_RS12925 ENOG4108W0S formate-dependent nitrite reductase complex H0910_RS12940 ENOG4105R8A Heat shock protein H0910_RS12945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0910_RS12950 ENOG4107Z6A sulfate abc transporter permease H0910_RS12955 ENOG4107QKW extracellular solute-binding protein family 1 H0910_RS12960 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin H0910_RS12965 ENOG4108T65 Fimbrial H0910_RS12970 ENOG4108SQA Fimbrial H0910_RS12975 ENOG4105CW0 outer membrane usher protein H0910_RS12980 ENOG4108NAE Fimbrial chaperone protein H0910_RS12985 ENOG4108S54 Fimbrial protein H0910_RS12990 ENOG4108RQP Major type 1 subunit fimbrin H0910_RS13000 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit H0910_RS13025 ENOG4108KZE transcriptional regulator H0910_RS13030 ENOG4106H6R UPF0380 protein H0910_RS13035 ENOG4106549 Antirestriction protein H0910_RS13080 ENOG4105KBH arsR family transcriptional regulator H0910_RS13105 ENOG4107RRE RNA-directed DNA polymerase H0910_RS13120 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H0910_RS13125 ENOG4105WQ3 Rna-binding protein H0910_RS13135 ENOG4105C8N cysteinyl-tRNA synthetase H0910_RS13140 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0910_RS13145 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H0910_RS13150 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H0910_RS13155 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H0910_RS13170 ENOG4105CV6 ABC transporter, permease H0910_RS13175 ENOG4108I0Y (ABC) transporter H0910_RS13180 ENOG4108UJV acyl-CoA thioesterase i H0910_RS13185 ENOG4105E1F short-chain dehydrogenase reductase H0910_RS13190 ENOG4107QR8 Thioredoxin H0910_RS13195 ENOG4107QX8 SPFH domain, Band 7 family protein H0910_RS13200 ENOG4105G5H Membrane H0910_RS13205 ENOG4108Z6Z Transcriptional regulator H0910_RS13210 ENOG4105C59 p-type ATPase H0910_RS13215 ENOG4108YK4 Acid-resistance membrane protein H0910_RS13220 ENOG4105MBR gumn family H0910_RS13225 ENOG4108Z66 YbaK ebsC protein H0910_RS13230 ENOG4105CGH 5'-nucleotidase H0910_RS13235 ENOG4105EU0 Major facilitator Superfamily H0910_RS13240 ENOG4105CKD glutathione-regulated potassium-efflux system protein H0910_RS13250 ENOG4105E98 transcriptional regulator DeoR family H0910_RS13265 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H0910_RS13270 ENOG4105ENY Ethanolamine utilization protein eutH H0910_RS13275 ENOG4107RE1 Inosine-guanosine kinase H0910_RS13280 ENOG4108QY5 Ferric enterobactin transport protein H0910_RS13290 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H0910_RS13295 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H0910_RS13300 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H0910_RS13305 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H0910_RS13310 ENOG4107QMP dna polymerase iii subunits gamma and tau H0910_RS13315 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) H0910_RS13330 ENOG4105EGS Mechanosensitive ion channel H0910_RS13335 ENOG41090EX DsrE family H0910_RS13340 ENOG4107XI7 Tetr family transcriptional regulator H0910_RS13345 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0910_RS13350 ENOG4105BZS acriflavin resistance protein H0910_RS13365 ENOG4105C8P )-transporter H0910_RS13375 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H0910_RS13380 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H0910_RS13385 ENOG4105DXN mazG family H0910_RS13390 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0910_RS13395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H0910_RS13405 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) H0910_RS13410 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H0910_RS13415 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H0910_RS13420 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H0910_RS13425 ENOG4105BZ4 penicillin-binding protein H0910_RS13430 ENOG4105CQ7 ATP-dependent helicase H0910_RS13435 ENOG4105PW4 Sugar fermentation stimulation protein homolog H0910_RS13440 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters H0910_RS13445 ENOG4105DJ0 Poly(A) Polymerase H0910_RS13450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H0910_RS13455 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H0910_RS13460 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) H0910_RS13465 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H0910_RS13470 ENOG4105E3A (ABC) transporter H0910_RS13475 ENOG4105DA5 (ABC) transporter H0910_RS13480 ENOG41077A9 carbonic anhydrase H0910_RS13485 ENOG4108UGV hypoxanthine phosphoribosyltransferase H0910_RS13490 ENOG4105E3B Multicopper oxidase H0910_RS13495 ENOG4108ZRK uncharacterized protein yacC H0910_RS13510 ENOG4105EQN UPF0261 protein H0910_RS13525 ENOG4105DGA Diaminopimelate dehydrogenase H0910_RS13530 ENOG4105UQX Mate efflux family protein H0910_RS13540 ENOG4105CKI cobalamin synthesis protein H0910_RS13545 ENOG4105VCD cytoplasmic protein H0910_RS13550 ENOG4105D22 carbon starvation protein H0910_RS13560 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) H0910_RS13570 ENOG4105FR1 rard protein H0910_RS13575 ENOG4108ZXC Two component transcriptional regulator, luxr family H0910_RS13580 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H0910_RS13585 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) H0910_RS13600 ENOG4105WP5 H0910_RS13610 ENOG410650H (LipO)protein H0910_RS13615 ENOG4105DBE peroxidase H0910_RS13630 ENOG4105DUM transcriptional regulator, lysR family H0910_RS13640 ENOG4105C7N Xanthine uracil vitamin C permease H0910_RS13650 ENOG4105D6U Sodium Glutamate Symporter H0910_RS13655 ENOG4105RQF LysR family Transcriptional regulator H0910_RS13660 ENOG4105MWK D-amino acid dehydrogenase, small subunit H0910_RS13665 ENOG4105M4H endoribonuclease L-psp H0910_RS13670 ENOG4107RA9 decarboxylase H0910_RS13675 ENOG4105KHU inner membrane protein YohD H0910_RS13685 ENOG4107RA9 decarboxylase H0910_RS13690 ENOG4108KB2 LysR family Transcriptional regulator H0910_RS13695 ENOG4105MZU cell filamentation protein H0910_RS13730 ENOG4105XIV Mercuric transport protein, periplasmic component H0910_RS13745 ENOG4108X6F Transcriptional regulator MerD H0910_RS13775 ENOG4108ZHR arsR family transcriptional regulator H0910_RS13885 ENOG4108BUD transposase H0910_RS13935 ENOG4105EUV Phenol 2-monooxygenase H0910_RS13950 ENOG4108BUD transposase H0910_RS13975 ENOG4108BUD transposase H0910_RS13985 ENOG4108BUD transposase H0910_RS14000 ENOG410607W Transposase H0910_RS14065 ENOG4105HVQ Regulatory factor of maltose metabolism H0910_RS14090 ENOG4105DZR Type I site-specific deoxyribonuclease H0910_RS14100 ENOG4105CVR type I restriction-modification system H0910_RS14110 ENOG4107R08 Integrase H0910_RS14115 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) H0910_RS14120 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase H0910_RS14130 ENOG4108K5P (LipO)protein H0910_RS14140 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) H0910_RS14145 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) H0910_RS14150 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) H0910_RS14155 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) H0910_RS14160 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H0910_RS14165 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) H0910_RS14170 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) H0910_RS14175 ENOG4105C11 sulfate adenylyltransferase), subunit 2 H0910_RS14180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H0910_RS14185 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) H0910_RS14190 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H0910_RS14195 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H0910_RS14200 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H0910_RS14205 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H0910_RS14210 ENOG4105C85 amino acid H0910_RS14230 ENOG4108XC3 NADH ubiquinone oxidoreductase H0910_RS14235 ENOG4107NA1 Endonuclease Exonuclease phosphatase H0910_RS14265 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H0910_RS14270 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0910_RS14275 ENOG4108UMI ABC transporter, permease H0910_RS14280 ENOG4105D01 (LipO)protein H0910_RS14290 ENOG4108R96 Methyltransferase, YaeB family H0910_RS14295 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H0910_RS14300 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion H0910_RS14305 ENOG4105M1T rho-binding antiterminator H0910_RS14310 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H0910_RS14320 ENOG4105C0B DNA polymerase III (alpha subunit) H0910_RS14325 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0910_RS14330 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0910_RS14335 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0910_RS14340 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H0910_RS14345 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0910_RS14350 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) H0910_RS14355 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0910_RS14360 ENOG4105DZP Membrane-associated zinc metalloprotease H0910_RS14365 ENOG4105KNE Phosphatidate cytidylyltransferase H0910_RS14370 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H0910_RS14375 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H0910_RS14380 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H0910_RS14385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H0910_RS14390 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H0910_RS14400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H0910_RS14405 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) H0910_RS14410 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) H0910_RS14415 ENOG4108T8E UPF0325 protein H0910_RS14420 ENOG4105QDK Flavodoxin H0910_RS14425 ENOG4105DR9 pseudouridine synthase H0910_RS14430 ENOG4105WP7 tRNA pseudouridine synthase C H0910_RS14440 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) H0910_RS14445 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) H0910_RS14450 ENOG4105EWT decarboxylase family H0910_RS14455 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease H0910_RS14460 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) H0910_RS14465 ENOG4105M08 Membrane H0910_RS14470 ENOG4105ETT transcriptional Regulator, LysR family H0910_RS14475 ENOG4105C9B Cysteine desulfurase H0910_RS14480 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H0910_RS14485 ENOG4105CUZ uba thif-type nad fad binding protein H0910_RS14490 ENOG4105CA3 membrane-bound lytic murein transglycosylase H0910_RS14510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0910_RS14515 ENOG4107QZM n-acetylglutamate synthase H0910_RS14525 ENOG4107QYX exodeoxyribonuclease v alpha H0910_RS14530 ENOG4107QKA exodeoxyribonuclease V beta H0910_RS14535 ENOG4107QXK peptidase H0910_RS14540 ENOG4105DSY exodeoxyribonuclease V, gamma H0910_RS14565 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H0910_RS14570 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H0910_RS14575 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase H0910_RS14580 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H0910_RS14585 ENOG4105DP9 ABC transporter H0910_RS14590 ENOG4106SMU thiamine transporter membrane protein H0910_RS14595 ENOG4107T0D ABC, transporter H0910_RS14600 ENOG4105CQ2 DNA polymerase H0910_RS14605 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H0910_RS14610 ENOG4105D3G Pseudouridine synthase H0910_RS14615 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) H0910_RS14620 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H0910_RS14625 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0910_RS14635 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H0910_RS14640 ENOG4105NWN ApaG protein H0910_RS14645 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H0910_RS14650 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H0910_RS14655 ENOG4105N14 lysine exporter protein LysE YggA H0910_RS14660 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) H0910_RS14665 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase H0910_RS14670 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0910_RS14675 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0910_RS14680 ENOG4105IPS esterase H0910_RS14685 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H0910_RS14690 ENOG41087AY ADP-Ribose pyrophosphatase H0910_RS14695 ENOG4105DFG type I secretion outer membrane protein H0910_RS14700 ENOG4105F1G UPF0441 protein H0910_RS14705 ENOG4106032 Glutathionylspermidine synthase H0910_RS14710 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H0910_RS14715 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H0910_RS14720 ENOG4105W0Z cytoplasmic protein H0910_RS14725 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) H0910_RS14730 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) H0910_RS14735 ENOG4105I7R Adenylate cyclase H0910_RS14740 ENOG4106MWK domain protein H0910_RS14750 ENOG4107ZVW dihydroneopterin aldolase H0910_RS14755 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) H0910_RS14760 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor H0910_RS14765 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H0910_RS14775 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H0910_RS14780 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0910_RS14790 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0910_RS14795 ENOG4105JQN Transcriptional regulator H0910_RS14800 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H0910_RS14805 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H0910_RS14810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0910_RS14815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0910_RS14820 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein H0910_RS14825 ENOG4105C45 hydrogenase expression formation protein (HypE) H0910_RS14830 ENOG4105CQS hydrogenase expression formation protein HypD H0910_RS14835 ENOG41082MF Hydrogenase assembly chaperone hypC hupF H0910_RS14840 ENOG4107RSS Hydrogenase accessory protein HypB H0910_RS14845 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) H0910_RS14850 ENOG4108WGS hydrogenase 2-specific chaperone H0910_RS14855 ENOG4108USZ hydrogenase H0910_RS14860 ENOG4105DPX Hydrogenase, large subunit H0910_RS14865 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit H0910_RS14870 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0910_RS14875 ENOG4105E3S small subunit H0910_RS14880 ENOG4105C8H hydrogenase maturation protein Hypf H0910_RS14905 ENOG4108FZ9 Chaperone H0910_RS14910 ENOG4106PG1 outer membrane usher protein H0910_RS14940 ENOG4108P8R H0910_RS14945 ENOG4105JXR Protein of unknown function (DUF3296) H0910_RS14980 ENOG4105UYK outer membrane protein a H0910_RS14990 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0910_RS15070 ENOG4105TS0 gtp-binding protein H0910_RS15075 ENOG4106549 Antirestriction protein H0910_RS15080 ENOG4106549 Antirestriction protein H0910_RS15085 ENOG4106H6R UPF0380 protein H0910_RS15095 ENOG4105T40 surface antigen msp4 family protein H0910_RS15120 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) H0910_RS15130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0910_RS15135 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) H0910_RS15145 ENOG4105DU1 integral membrane protein, terc H0910_RS15150 ENOG4106W5V Membrane H0910_RS15155 ENOG4105NE1 Conserved Protein H0910_RS15160 ENOG41090KG Inner membrane protein YqjE H0910_RS15170 ENOG4108VBZ doxx family H0910_RS15175 ENOG4105CWB LysR family transcriptional Regulator H0910_RS15180 ENOG4108CNN domain protein H0910_RS15185 ENOG4105EMD TRANSCRIPTIONal H0910_RS15215 ENOG41069H0 dihydroorotase EC 3.5.2.3 H0910_RS15230 ENOG4105HEE Binding Domain protein H0910_RS15240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H0910_RS15250 ENOG41082RQ UPF0102 protein H0910_RS15255 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) H0910_RS15260 ENOG4105W4M Transport-associated protein H0910_RS15265 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase H0910_RS15270 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain H0910_RS15275 ENOG4105BZU Histidine kinase H0910_RS15280 ENOG4105BZ8 glutamate synthase H0910_RS15285 ENOG4105KB2 stringent starvation protein b H0910_RS15290 ENOG4107MKT Stringent starvation protein a H0910_RS15295 ENOG4108UJD 30S ribosomal protein S9 H0910_RS15300 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H0910_RS15305 ENOG4105D6Z AFG1 family ATPase H0910_RS15310 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III H0910_RS15315 ENOG4105C0H protease H0910_RS15320 ENOG4105C0H protease H0910_RS15325 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H0910_RS15330 ENOG4105VFK BolA family H0910_RS15340 ENOG4105E3I toluene tolerance H0910_RS15345 ENOG4107PE3 Mammalian cell entry related domain protein H0910_RS15350 ENOG4105CY3 ABC transporter, permease H0910_RS15355 ENOG4105DHJ ABC, transporter H0910_RS15360 ENOG4105C2X Arabinose 5-phosphate isomerase H0910_RS15365 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase H0910_RS15370 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) H0910_RS15375 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H0910_RS15380 ENOG4108IUZ ABC transporter H0910_RS15385 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0910_RS15390 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA H0910_RS15395 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN H0910_RS15400 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H0910_RS15405 ENOG41080Z8 PHOSPHOCARRIER protein H0910_RS15410 ENOG4105NXH GreA GreB family elongation factor H0910_RS15415 ENOG4105CMS peptidase U62, modulator of DNA gyrase H0910_RS15420 ENOG4105N42 UPF0307 protein H0910_RS15430 ENOG41067XF inhibitor H0910_RS15440 ENOG4105D1U peptidase U62 modulator of DNA gyrase H0910_RS15450 ENOG4105QD6 exported protein H0910_RS15455 ENOG4105C03 ribonuclease H0910_RS15460 ENOG4108Z03 MAF-like protein H0910_RS15465 ENOG4105VQ7 Rod shape-determining protein MreD H0910_RS15470 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H0910_RS15480 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H0910_RS15485 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) H0910_RS15490 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H0910_RS15495 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H0910_RS15500 ENOG4105RG0 Membrane H0910_RS15505 ENOG4108IA2 Sodium pantothenate symporter H0910_RS15510 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H0910_RS15520 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) H0910_RS15540 ENOG4105C8Q Methyl-accepting chemotaxis H0910_RS15560 ENOG4105S66 prophage protein H0910_RS15565 ENOG4105D2S major facilitator superfamily H0910_RS15580 ENOG4105CZE histidine utilization repressor H0910_RS15585 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H0910_RS15590 ENOG4105C10 Electron transfer flavoprotein H0910_RS15595 ENOG4105BZJ Electron transfer flavoprotein H0910_RS15600 ENOG4105ETS cytosine purines uracil thiamine allantoin H0910_RS15605 ENOG4105C1G acyl-Coa dehydrogenase H0910_RS15615 ENOG4105CGP Urocanate hydratase H0910_RS15625 ENOG4108IV0 ABC, transporter H0910_RS15630 ENOG4105C0Z ABC transporter H0910_RS15635 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H0910_RS15640 ENOG4105C32 Amino acid ABC transporter (Permease) H0910_RS15645 ENOG4105CP9 extracellular ligand-binding receptor H0910_RS15650 ENOG4105U59 -acetyltransferase H0910_RS15655 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H0910_RS15660 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0910_RS15665 ENOG4105CRP Part of the ABC transporter FtsEX involved in H0910_RS15670 ENOG4105CAK Cell division ATP-binding protein ftsE H0910_RS15675 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H0910_RS15675 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H0910_RS15680 ENOG4106H78 methyltransferase H0910_RS15685 ENOG4105MG3 Membrane H0910_RS15695 ENOG4107FS9 Membrane H0910_RS15705 ENOG4105DNE Transposase H0910_RS15715 ENOG4105EX9 Membrane H0910_RS15720 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H0910_RS15730 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A H0910_RS15735 ENOG4105CXY transporter H0910_RS15740 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H0910_RS15750 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) H0910_RS15765 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) H0910_RS15770 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) H0910_RS15780 ENOG4105CSH Transporter H0910_RS15790 ENOG4105HVQ Regulatory factor of maltose metabolism H0910_RS15800 ENOG4108594 Permease of the drug metabolite transporter H0910_RS15805 ENOG4105D22 carbon starvation protein H0910_RS15810 ENOG4105VCD cytoplasmic protein H0910_RS15815 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H0910_RS15820 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H0910_RS15825 ENOG4108ZVF (LipO)protein H0910_RS15830 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H0910_RS15835 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) H0910_RS15845 ENOG4108IJ0 Aspartate ammonia-lyase H0910_RS15850 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H0910_RS15855 ENOG4105ZUU Transcriptional regulator H0910_RS15890 ENOG4108NAE Fimbrial chaperone protein H0910_RS15930 ENOG4108NNI Beta-lactamase domain-containing protein H0910_RS15935 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase H0910_RS15940 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0910_RS15945 ENOG4105BZW Glycerate kinase H0910_RS15950 ENOG4108WRK Transcriptional regulator H0910_RS15955 ENOG4108SIC Transcriptional regulator H0910_RS16020 ENOG4105C4R Atp-dependent dna helicase H0910_RS16025 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H0910_RS16060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0910_RS16125 ENOG4105CS6 Rhs element vgr protein H0910_RS16180 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis H0910_RS16225 ENOG4105TS0 gtp-binding protein H0910_RS16230 ENOG4106549 Antirestriction protein H0910_RS16235 ENOG4106H6R UPF0380 protein H0910_RS16240 ENOG4105T40 surface antigen msp4 family protein H0910_RS16260 ENOG4105D7K pfkb domain protein H0910_RS16265 ENOG4106NDP Transcriptional regulator H0910_RS16275 ENOG4108HKT sucrose-6-phosphate hydrolase H0910_RS16280 ENOG4108Q3X Transcriptional regulator H0910_RS16285 ENOG4105CI1 PTS System H0910_RS16300 ENOG4105DNE Transposase H0910_RS16305 ENOG4107T6V glycerophosphoryl diester phosphodiesterase H0910_RS16325 ENOG4105BZ7 extracellular solute-binding protein family 1 H0910_RS16330 ENOG4105CFC Transporter H0910_RS16335 ENOG4105VTS DnaJ-like, subfamily C H0910_RS16340 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) H0910_RS16345 ENOG4108Z7R Chaperone CsaA H0910_RS16365 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) H0910_RS16370 ENOG4105KNY Microcompartments protein H0910_RS16375 ENOG4105F1A Pyruvate formate-lyase H0910_RS16380 ENOG4105C6N Formate acetyltransferase H0910_RS16395 ENOG4105C0A alcohol dehydrogenase H0910_RS16400 ENOG4105KNY Microcompartments protein H0910_RS16405 ENOG4105KNY Microcompartments protein H0910_RS16410 ENOG4105KNY Microcompartments protein H0910_RS16435 ENOG4107RUE extracellular solute-binding protein family 1 H0910_RS16440 ENOG4105D38 putrescine abc transporter H0910_RS16455 ENOG4107GFK fumarate H0910_RS16460 ENOG4107BJW polysaccharide deacetylase H0910_RS16465 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H0910_RS16470 ENOG4105E98 transcriptional regulator DeoR family H0910_RS16480 ENOG4105C2J ABC transporter H0910_RS16485 ENOG4105CNN ABC, transporter H0910_RS16490 ENOG4105F5R ABC transporter H0910_RS16495 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase H0910_RS16500 ENOG4105CMG Carbohydrate kinase H0910_RS16505 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein H0910_RS16520 ENOG4108IPW abc transporter atp-binding protein H0910_RS16525 ENOG4105CM4 permease protein H0910_RS16530 ENOG4105DHS permease protein H0910_RS16540 ENOG4105CG3 alpha amylase, catalytic region H0910_RS16555 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) H0910_RS16560 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) H0910_RS16565 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H0910_RS16590 ENOG4107RCV ABC transporter, permease H0910_RS16595 ENOG4105C4Y ABC transporter H0910_RS16615 ENOG4108JUA Transcriptional regulator H0910_RS16620 ENOG4108RC0 Electron transport protein H0910_RS16635 ENOG4105C6K Malic enzyme H0910_RS16640 ENOG4105C9Q fumarate hydratase class II H0910_RS16645 ENOG4108MG9 hydrogenase 3 maturation protease H0910_RS16650 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit H0910_RS16660 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0910_RS16665 ENOG4108JPZ Monovalent cation H antiporter subunit D H0910_RS16670 ENOG4107WQX hydrogenase 4 membrane subunit H0910_RS16675 ENOG4105D65 subunit l H0910_RS16680 ENOG4107TDF Formate hydrogenlyase subunit 4 H0910_RS16685 ENOG4108JPZ Monovalent cation H antiporter subunit D H0910_RS16690 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) H0910_RS16695 ENOG4105CA0 peroxidase H0910_RS16705 ENOG41069AG Ankyrin repeat H0910_RS16715 ENOG4105M6F mutator MutT protein H0910_RS16730 ENOG4105ZS6 Protein of unknown function (DUF987) H0910_RS16735 ENOG4108XS9 dna repair protein H0910_RS16740 ENOG4106H6R UPF0380 protein H0910_RS16745 ENOG4106549 Antirestriction protein H0910_RS16775 ENOG4106J9S Prophage H0910_RS16810 ENOG4105C0D helicase H0910_RS16820 ENOG4108I5C dEAD DEAH box helicase H0910_RS16825 ENOG4105C4R Atp-dependent dna helicase H0910_RS16865 ENOG4107R6D beta-lactam binding protein AmpH H0910_RS16870 ENOG4108K5H permease YjgP YjgQ family protein H0910_RS16875 ENOG4108M8S permease YjgP YjgQ family protein H0910_RS16880 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H0910_RS16885 ENOG4105MYG DNA polymerase iii, chi subunit H0910_RS16890 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H0910_RS16895 ENOG4108MJ3 acetyltransferase H0910_RS16910 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) H0910_RS16915 ENOG4105DBV ornithine carbamoyltransferase H0910_RS16925 ENOG4107STF Involved in phosphonate degradation (By similarity) H0910_RS16930 ENOG4106S9K Transcriptional regulator H0910_RS16935 ENOG4105CY5 solute-binding protein H0910_RS16945 ENOG4108MP3 ABC transporter, permease H0910_RS16950 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component H0910_RS16965 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) H0910_RS16970 ENOG4105KME endoribonuclease L-psp H0910_RS16975 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase H0910_RS16980 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) H0910_RS16985 ENOG4108ZPB UPF0306 protein H0910_RS16990 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction H0910_RS17000 ENOG4108YYD acetyltransferase H0910_RS17035 ENOG4107V40 secretion protein, HlyD family H0910_RS17040 ENOG4108HRK Histidine kinase H0910_RS17045 ENOG4108NEV two component transcriptional regulator, LytTR family H0910_RS17050 ENOG41062WK cellular response to acidity H0910_RS17055 ENOG4105C1J atp-dependent rna helicase H0910_RS17065 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H0910_RS17070 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H0910_RS17075 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H0910_RS17080 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H0910_RS17085 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H0910_RS17090 ENOG4105CHV Transcription elongation factor NusA H0910_RS17095 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) H0910_RS17110 ENOG4105NTZ Preprotein translocase subunit SecG H0910_RS17115 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H0910_RS17120 ENOG4105EEI dihydropteroate synthase H0910_RS17125 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H0910_RS17130 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) H0910_RS17135 ENOG4105HBR Rna-binding protein H0910_RS17140 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H0910_RS17145 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase H0910_RS17150 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H0910_RS17155 ENOG4105K46 50S ribosomal protein l27 H0910_RS17160 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H0910_RS17165 ENOG4105EAH synthase H0910_RS17180 ENOG4105HVQ Regulatory factor of maltose metabolism H0910_RS17185 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H0910_RS17190 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) H0910_RS17200 ENOG4105DFU Cell wall formation (By similarity) H0910_RS17205 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H0910_RS17210 ENOG4105F0N pyrophosphate phospho-hydrolase H0910_RS17215 ENOG4108ZHD aig2 family H0910_RS17220 ENOG4105MA0 exported protein H0910_RS17225 ENOG4105CFU surface antigen H0910_RS17230 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H0910_RS17235 ENOG4105C37 (CBS) domain H0910_RS17240 ENOG41061GZ Protein of unknown function (DUF1107) H0910_RS17245 ENOG4108UUE Transcriptional regulator H0910_RS17250 ENOG4105DHQ Histidine kinase H0910_RS17255 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0910_RS17260 ENOG4105H4F exported protein H0910_RS17265 ENOG4107VIJ nudix hydrolase H0910_RS17275 ENOG4105DWT malate dehydrogenase (quinone) H0910_RS17280 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase H0910_RS17285 ENOG4108V1T peptidylprolyl cis-trans isomerase H0910_RS17290 ENOG4105FHY Opacity-associated protein A H0910_RS17295 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) H0910_RS17300 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H0910_RS17305 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H0910_RS17310 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) H0910_RS17315 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) H0910_RS17320 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0910_RS17325 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H0910_RS17330 ENOG4105KPV Transcriptional regulator H0910_RS17335 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H0910_RS17340 ENOG4105EPW hflc protein H0910_RS17345 ENOG4107QJR hflk protein H0910_RS17350 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H0910_RS17355 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H0910_RS17360 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H0910_RS17365 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H0910_RS17370 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0910_RS17375 ENOG4105K8N protein family UPF0079, ATPase H0910_RS17380 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H0910_RS17405 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H0910_RS17410 ENOG4105DJ4 phosphatidylserine decarboxylase H0910_RS17415 ENOG4105EGS Mechanosensitive ion channel H0910_RS17430 ENOG4105DQF Hydrolase H0910_RS17435 ENOG4108EUD Lysophospholipase H0910_RS17440 ENOG4105C9U ATP-dependent DNA helicase RecQ H0910_RS17445 ENOG4105HDD phospholipase H0910_RS17450 ENOG4108VUY thioesterase Superfamily protein H0910_RS17455 ENOG4105FR1 rard protein H0910_RS17460 ENOG4105CUB amino acid H0910_RS17480 ENOG4108S2Y peptide Chain Release factor H0910_RS17500 ENOG4105C4R Atp-dependent dna helicase H0910_RS17505 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant H0910_RS17510 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0910_RS17515 ENOG4105CT0 Protein of unknown function, DUF484 H0910_RS17520 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H0910_RS17525 ENOG4105S7Z (LipO)protein H0910_RS17530 ENOG4105XQ6 frataxin-like protein H0910_RS17535 ENOG4107T0K Adenylate cyclase H0910_RS17540 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H0910_RS17545 ENOG41076E6 Uroporphyrinogen-III Synthase H0910_RS17550 ENOG4105ECF c-methyltransferase H0910_RS17555 ENOG410601J HemY protein H0910_RS17585 ENOG4105C85 amino acid H0910_RS17590 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family H0910_RS17595 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) H0910_RS17600 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) H0910_RS17605 ENOG4105EGZ biosynthesis protein H0910_RS17610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0910_RS17620 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H0910_RS17625 ENOG4105C1B dTDP-glucose 4-6-dehydratase H0910_RS17630 ENOG4108IJ1 Dehydrogenase H0910_RS17635 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H0910_RS17640 ENOG4105SFE lipopolysaccharide biosynthesis protein H0910_RS17645 ENOG4105ESV Glycosyl transferase, family 4 H0910_RS17650 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H0910_RS17660 ENOG4105C1J atp-dependent rna helicase H0910_RS17665 ENOG4105C9X ppx gppa phosphatase H0910_RS17670 ENOG4105C4R Atp-dependent dna helicase H0910_RS17675 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H0910_RS17680 ENOG4105EMY transcriptional regulator H0910_RS17685 ENOG4105C7B Threonine dehydratase H0910_RS17690 ENOG4105C01 Dihydroxy-acid dehydratase H0910_RS17695 ENOG4105CM2 brancheD-chain amino acid aminotransferase H0910_RS17700 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit H0910_RS17715 ENOG4105C0P Mg chelatase subunit ChlI H0910_RS17720 ENOG4108WFC UPF0438 protein yifE H0910_RS17725 ENOG4105CVI Transcriptional regulator H0910_RS17765 ENOG4108Z0R Transferase H0910_RS17770 ENOG4105SG3 Protein of unknown function (DUF1488) H0910_RS17775 ENOG4105E2X shikimate dehydrogenase H0910_RS17780 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H0910_RS17785 ENOG4108WI1 Dna topoisomerase H0910_RS17790 ENOG4105C79 DNA protecting protein DprA H0910_RS17795 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H0910_RS17800 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H0910_RS17805 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H0910_RS17810 ENOG4105C1A potassium transporter peripheral membrane H0910_RS17815 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H0910_RS17825 ENOG4105W1Y Transcriptional regulator H0910_RS17830 ENOG4108ZT0 50S ribosomal protein l17 H0910_RS17840 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H0910_RS17845 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) H0910_RS17850 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H0910_RS17855 ENOG41067V7 50S ribosomal protein L36 H0910_RS17860 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H0910_RS17865 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H0910_RS17870 ENOG4105VPB 50S ribosomal protein L30 H0910_RS17875 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H0910_RS17880 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H0910_RS17885 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H0910_RS17890 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H0910_RS17895 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H0910_RS17900 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H0910_RS17905 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H0910_RS17910 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) H0910_RS17915 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H0910_RS17920 ENOG41083MP 50s ribosomal protein l29 H0910_RS17925 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H0910_RS17930 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H0910_RS17935 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H0910_RS17945 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H0910_RS17950 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H0910_RS17955 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H0910_RS17960 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H0910_RS17980 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H0910_RS18005 ENOG4105CS9 pantothenic acid kinase H0910_RS18010 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H0910_RS18015 ENOG4105D4A Cell wall formation (By similarity) H0910_RS18050 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H0910_RS18055 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) H0910_RS18060 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) H0910_RS18065 ENOG4108Y73 Membrane H0910_RS18075 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) H0910_RS18080 ENOG4105C5Q Transcriptional regulator H0910_RS18090 ENOG4105CH7 arginosuccinase H0910_RS18095 ENOG4105CDH Citrulline--aspartate ligase H0910_RS18100 ENOG4105CAS nag kinase H0910_RS18105 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H0910_RS18110 ENOG4105CWC Acetylornithine deacetylase H0910_RS18115 ENOG4105SYT Methylenetetrahydrofolate reductase H0910_RS18120 ENOG4105CVK Glutamate decarboxylase H0910_RS18125 ENOG4105E5D amino acid H0910_RS18130 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) H0910_RS18135 ENOG4105CFH Aspartokinase H0910_RS18140 ENOG4105C28 cystathionine H0910_RS18145 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) H0910_RS18150 ENOG4105T40 surface antigen msp4 family protein H0910_RS18165 ENOG4105C25 Primosomal protein n' H0910_RS18170 ENOG4105ETE Transcriptional regulator (LacI family H0910_RS18175 ENOG41063M6 Cell Division Protein H0910_RS18180 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) H0910_RS18185 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) H0910_RS18190 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H0910_RS18195 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) H0910_RS18200 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) H0910_RS18205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H0910_RS18210 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H0910_RS18220 ENOG4105E5M Multidrug resistance protein D H0910_RS18225 ENOG4105DP0 ferredoxin-NADP reductase H0910_RS18230 ENOG4108VTS Membrane H0910_RS18235 ENOG4105EBK exported protein H0910_RS18240 ENOG4105CP7 Triose-phosphate isomerase H0910_RS18250 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H0910_RS18255 ENOG4105CTQ phosphohexokinase H0910_RS18260 ENOG4108HPI phosphatidate Cytidylyltransferase H0910_RS18270 ENOG4108K0D peptidase, M48 H0910_RS18275 ENOG41090B9 response to stress H0910_RS18280 ENOG4105FMW periplasmic H0910_RS18285 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0910_RS18290 ENOG4105E0F Histidine kinase H0910_RS18295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H0910_RS18305 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0910_RS18340 ENOG4105CG5 Glycosyl transferase (Group 1 H0910_RS18345 ENOG4105DMT epimerase dehydratase H0910_RS18350 ENOG4105CMR udp-glucose 4-epimerase H0910_RS18360 ENOG4105DAY polysaccharide export protein H0910_RS18365 ENOG4105KJF protein tyrosine phosphatase H0910_RS18370 ENOG4105D75 Capsular exopolysaccharide family H0910_RS18375 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H0910_RS18380 ENOG4105VTW prevent-host-death family H0910_RS18385 ENOG4105KRQ Addiction module toxin, Txe YoeB family H0910_RS18390 ENOG4105D7W serine acetyltransferase H0910_RS18395 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H0910_RS18400 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) H0910_RS18405 ENOG4107YZP Rhodanese domain protein H0910_RS18410 ENOG41063SB peptidase H0910_RS18415 ENOG4105PXI polysaccharide deacetylase H0910_RS18420 ENOG4105CPQ Dehydrogenase H0910_RS18425 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0910_RS18430 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) H0910_RS18435 ENOG4105XA0 heptosyltransferase ii H0910_RS18440 ENOG4105D16 lipopolysaccharide heptosyltransferase i H0910_RS18450 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H0910_RS18455 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H0910_RS18460 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H0910_RS18465 ENOG41068PG O-Antigen polymerase H0910_RS18470 ENOG4105K64 Glycosyl transferase, family 2 H0910_RS18475 ENOG4108I6E Sulfatase H0910_RS18480 ENOG4108I6E Sulfatase H0910_RS18485 ENOG4105X1N Glycosyl transferase family 8 H0910_RS18490 ENOG4106AH0 Glycosyl Transferase H0910_RS18495 ENOG4107543 (lipo)polysaccharide H0910_RS18500 ENOG4107RJ7 Glycosyl transferase (Group 1 H0910_RS18505 ENOG4105DKP glycosyl transferase, family 9 H0910_RS18515 ENOG4105KDC 50s ribosomal protein l28 H0910_RS18520 ENOG4105W5Q DNA repair protein (RadC H0910_RS18525 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H0910_RS18530 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H0910_RS18535 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) H0910_RS18540 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) H0910_RS18545 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H0910_RS18550 ENOG4105DSJ YicC domain protein H0910_RS18560 ENOG4105EAA nucleoside H0910_RS18585 ENOG4107T7U Sulfatase H0910_RS18590 ENOG4105EM7 Selenocysteine-specific translation elongation factor H0910_RS18595 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) H0910_RS18600 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) H0910_RS18610 ENOG4108MG3 formate dehydrogenase H0910_RS18615 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0910_RS18625 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H0910_RS18635 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H0910_RS18640 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H0910_RS18645 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H0910_RS18650 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) H0910_RS18655 ENOG4105VG0 50S ribosomal protein l34