locus-tag	class	description
pBML2531_RS00010	COG1522	sequence-specific DNA binding
pBML2531_RS00015	COG0492	ferredoxin-NADP+ reductase activity
pBML2531_RS00020	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
pBML2531_RS00030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
pBML2531_RS00035	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
pBML2531_RS00040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
pBML2531_RS00045	COG0542	response to heat
pBML2531_RS00050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
pBML2531_RS00055	COG1278	Cold shock
pBML2531_RS00065	COG1414	Transcriptional regulator
pBML2531_RS00070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
pBML2531_RS00070	COG3153	acetyltransferase
pBML2531_RS00080	COG2186	Transcriptional regulator
pBML2531_RS00085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
pBML2531_RS00085	COG0473	3-isopropylmalate dehydrogenase activity
pBML2531_RS00090	COG2271	Major facilitator Superfamily
pBML2531_RS00100	COG0577	efflux transmembrane transporter activity
pBML2531_RS00100	COG1136	(ABC) transporter
pBML2531_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
pBML2531_RS00110	COG3593	DNA synthesis involved in DNA repair
pBML2531_RS00115	COG2431	L-lysine efflux transmembrane transporter activity
pBML2531_RS00120	COG0702	epimerase
pBML2531_RS00125	COG1126	abc transporter atp-binding protein
pBML2531_RS00130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
pBML2531_RS00135	COG4215	(ABC) transporter
pBML2531_RS00140	COG4160	amino acid transport
pBML2531_RS00150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
pBML2531_RS00170	COG0432	Pfam Uncharacterised protein family UPF0047
pBML2531_RS00175	COG0671	phosphoesterase, PA-phosphatase related
pBML2531_RS00180	COG0814	amino acid
pBML2531_RS00185	COG1760	l-serine dehydratase
pBML2531_RS00190	COG1686	Belongs to the peptidase S11 family
pBML2531_RS00195	COG0625	glutathione transferase activity
pBML2531_RS00200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
pBML2531_RS00210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
pBML2531_RS00215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
pBML2531_RS00215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
pBML2531_RS00220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
pBML2531_RS00220	COG0131	Imidazoleglycerol-phosphate dehydratase
pBML2531_RS00230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
pBML2531_RS00235	COG0107	imidazoleglycerol-phosphate synthase activity
pBML2531_RS00240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
pBML2531_RS00240	COG0140	phosphoribosyl-ATP diphosphatase activity
pBML2531_RS00255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
pBML2531_RS00280	COG1253	flavin adenine dinucleotide binding
pBML2531_RS00290	COG2982	Protein involved in outer membrane biogenesis
pBML2531_RS00295	COG0717	Belongs to the dCTP deaminase family
pBML2531_RS00300	COG0572	uridine kinase
pBML2531_RS00305	COG0501	Belongs to the peptidase M48B family
pBML2531_RS00315	COG0489	protein tyrosine kinase activity
pBML2531_RS00320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
pBML2531_RS00320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
pBML2531_RS00325	COG1380	Effector of murein hydrolase LrgA
pBML2531_RS00330	COG1346	cytolysis
pBML2531_RS00370	COG0281	malic enzyme
pBML2531_RS00390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS00390	COG1263	PTS System
pBML2531_RS00405	COG2949	membrane
pBML2531_RS00410	COG2311	Membrane
pBML2531_RS00415	COG0302	gtp cyclohydrolase
pBML2531_RS00420	COG0303	'Molybdopterin
pBML2531_RS00425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
pBML2531_RS00430	COG2824	Alkylphosphonate utilization operon protein PhnA
pBML2531_RS00435	COG0488	(ABC) transporter
pBML2531_RS00450	COG5006	permease, DMT superfamily
pBML2531_RS00470	COG2897	thiosulfate sulfurtransferase activity
pBML2531_RS00475	COG2261	transglycosylase associated protein
pBML2531_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
pBML2531_RS00485	COG0513	Belongs to the DEAD box helicase family
pBML2531_RS00490	COG1309	transcriptional regulator
pBML2531_RS00500	COG1131	(ABC) transporter
pBML2531_RS00505	COG0842	Transport permease protein
pBML2531_RS00510	COG0842	Transport permease protein
pBML2531_RS00515	COG0670	Belongs to the BI1 family
pBML2531_RS00520	COG0314	molybdopterin synthase activity
pBML2531_RS00525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
pBML2531_RS00535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
pBML2531_RS00545	COG0556	nucleotide-excision repair
pBML2531_RS00555	COG2226	methyltransferase
pBML2531_RS00565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
pBML2531_RS00575	COG2706	6-phosphogluconolactonase activity
pBML2531_RS00580	COG0561	phosphatase activity
pBML2531_RS00590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
pBML2531_RS00600	COG0477	Major facilitator Superfamily
pBML2531_RS00605	COG0246	Mannitol dehydrogenase
pBML2531_RS00610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
pBML2531_RS00615	COG4149	molybdate abc transporter
pBML2531_RS00620	COG0725	ABC transporter, periplasmic molybdate-binding protein
pBML2531_RS00640	COG2005	Transcriptional regulator
pBML2531_RS00640	COG3585	molybdate ion transport
pBML2531_RS00645	COG1119	ATPase activity
pBML2531_RS00665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
pBML2531_RS00665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS00665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
pBML2531_RS00665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS00665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS00665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS00670	COG0383	alpha-mannosidase activity
pBML2531_RS00675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
pBML2531_RS00675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
pBML2531_RS00675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
pBML2531_RS00680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
pBML2531_RS00690	COG0588	phosphoglycerate mutase activity
pBML2531_RS00705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
pBML2531_RS00715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
pBML2531_RS00740	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
pBML2531_RS00745	COG2885	chlorophyll binding
pBML2531_RS00750	COG0823	Involved in the tonB-independent uptake of proteins
pBML2531_RS00755	COG3064	Membrane
pBML2531_RS00760	COG0848	biopolymer transport protein
pBML2531_RS00765	COG0811	peptide transport
pBML2531_RS00770	COG0824	Thioesterase
pBML2531_RS00780	COG4890	Cyd operon protein YbgT
pBML2531_RS00785	COG1294	oxidase, subunit
pBML2531_RS00790	COG1271	oxidase subunit
pBML2531_RS00795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
pBML2531_RS00800	COG0045	succinate-CoA ligase (ADP-forming) activity
pBML2531_RS00805	COG0508	dehydrogenase complex catalyzes the overall conversion of
pBML2531_RS00810	COG0567	Dehydrogenase, E1 component
pBML2531_RS00820	COG1053	succinate dehydrogenase
pBML2531_RS00825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
pBML2531_RS00845	COG2814	Major facilitator Superfamily
pBML2531_RS00850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
pBML2531_RS00880	COG3501	Rhs element vgr protein
pBML2531_RS00890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
pBML2531_RS00910	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
pBML2531_RS00915	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
pBML2531_RS00920	COG2205	protein histidine kinase activity
pBML2531_RS00925	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS00935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
pBML2531_RS00955	COG2190	(PTS) system
pBML2531_RS00955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS00955	COG1263	PTS System
pBML2531_RS00960	COG0363	glucosamine-6-phosphate deaminase activity
pBML2531_RS00965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
pBML2531_RS00970	COG1940	carbohydrate kinase activity
pBML2531_RS00970	COG1846	Transcriptional regulator
pBML2531_RS01015	COG1301	dicarboxylic acid transport
pBML2531_RS01020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
pBML2531_RS01025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
pBML2531_RS01030	COG1702	phosphate starvation-inducible protein PhoH
pBML2531_RS01035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
pBML2531_RS01040	COG4535	Mg2 and Co2 transporter CorC
pBML2531_RS01045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
pBML2531_RS01070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
pBML2531_RS01075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
pBML2531_RS01075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
pBML2531_RS01095	COG0765	amino acid transport
pBML2531_RS01100	COG0765	amino acid transport
pBML2531_RS01105	COG1126	abc transporter atp-binding protein
pBML2531_RS01110	COG0495	leucyl-tRNA aminoacylation
pBML2531_RS01115	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
pBML2531_RS01120	COG1466	dna polymerase III delta subunit
pBML2531_RS01135	COG0799	negative regulation of ribosome biogenesis
pBML2531_RS01140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
pBML2531_RS01145	COG0768	penicillin binding
pBML2531_RS01150	COG0772	Belongs to the SEDS family
pBML2531_RS01155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
pBML2531_RS01160	COG1686	Belongs to the peptidase S11 family
pBML2531_RS01165	COG2921	Belongs to the UPF0250 family
pBML2531_RS01170	COG0321	lipoyl(octanoyl) transferase activity
pBML2531_RS01175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
pBML2531_RS01180	COG1278	Cold shock
pBML2531_RS01185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
pBML2531_RS01190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
pBML2531_RS01195	COG1780	Probably involved in ribonucleotide reductase function
pBML2531_RS01210	COG4175	Glycine betaine
pBML2531_RS01215	COG4176	ABC-type proline glycine betaine transport system permease component
pBML2531_RS01220	COG2113	Glycine betaine
pBML2531_RS01225	COG2814	Major facilitator Superfamily
pBML2531_RS01230	COG1846	Transcriptional regulator
pBML2531_RS01235	COG1566	PFAM secretion protein HlyD family protein
pBML2531_RS01240	COG2814	Major facilitator Superfamily
pBML2531_RS01245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
pBML2531_RS01260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
pBML2531_RS01265	COG5544	Lipoprotein
pBML2531_RS01280	COG0640	Transcriptional regulator
pBML2531_RS01315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
pBML2531_RS01320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
pBML2531_RS01325	COG2011	ABC-type metal ion transport system permease component
pBML2531_RS01330	COG1464	Belongs to the NlpA lipoprotein family
pBML2531_RS01340	COG1720	tRNA m6t6A37 methyltransferase activity
pBML2531_RS01345	COG0442	prolyl-tRNA aminoacylation
pBML2531_RS01355	COG1486	melibiose metabolic process
pBML2531_RS01360	COG1917	Cupin 2, conserved barrel domain protein
pBML2531_RS01360	COG2169	Transcriptional regulator
pBML2531_RS01365	COG1447	Phosphotransferase system cellobiose-specific component IIA
pBML2531_RS01370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
pBML2531_RS01375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
pBML2531_RS01380	COG3015	lipoprotein NlpE involved in copper resistance
pBML2531_RS01385	COG4568	rho-dependent transcription termination
pBML2531_RS01390	COG0037	tRNA processing
pBML2531_RS01410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
pBML2531_RS01415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
pBML2531_RS01420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
pBML2531_RS01425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
pBML2531_RS01430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
pBML2531_RS01440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
pBML2531_RS01445	COG0750	zinc metalloprotease
pBML2531_RS01450	COG0575	Belongs to the CDS family
pBML2531_RS01455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
pBML2531_RS01460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
pBML2531_RS01465	COG0233	cytoplasmic translational termination
pBML2531_RS01470	COG0528	UMP kinase activity
pBML2531_RS01475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
pBML2531_RS01490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
pBML2531_RS01505	COG0716	FMN binding
pBML2531_RS01510	COG0564	pseudouridine synthase activity
pBML2531_RS01515	COG3098	single-species biofilm formation
pBML2531_RS01535	COG1611	Belongs to the LOG family
pBML2531_RS01550	COG2363	Small membrane protein
pBML2531_RS01555	COG0583	DNA-binding transcription factor activity
pBML2531_RS01560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
pBML2531_RS01565	COG2166	iron-sulfur cluster assembly
pBML2531_RS01570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
pBML2531_RS01575	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
pBML2531_RS01595	COG0860	N-Acetylmuramoyl-L-alanine amidase
pBML2531_RS01600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
pBML2531_RS01600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
pBML2531_RS01610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
pBML2531_RS01615	COG1074	ATP-dependent DNA helicase activity
pBML2531_RS01625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
pBML2531_RS01655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
pBML2531_RS01665	COG0494	nUDIX hydrolase
pBML2531_RS01670	COG4143	(ABC) transporter
pBML2531_RS01675	COG1178	ABC-type Fe3 transport system permease component
pBML2531_RS01680	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
pBML2531_RS01685	COG0417	DNA replication proofreading
pBML2531_RS01690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
pBML2531_RS01695	COG0564	pseudouridine synthase activity
pBML2531_RS01700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
pBML2531_RS01705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
pBML2531_RS01710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
pBML2531_RS01715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
pBML2531_RS01720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
pBML2531_RS01725	COG2967	ApaG domain
pBML2531_RS01730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
pBML2531_RS01735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
pBML2531_RS01740	COG1280	lysine exporter protein (LysE YggA)
pBML2531_RS01745	COG2132	Multicopper oxidase
pBML2531_RS01750	COG0204	Acyl-transferase
pBML2531_RS01760	COG0187	DNA topoisomerase II activity
pBML2531_RS01765	COG3150	esterase
pBML2531_RS01770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
pBML2531_RS01775	COG0494	nUDIX hydrolase
pBML2531_RS01785	COG5463	Belongs to the UPF0441 family
pBML2531_RS01790	COG0754	glutathionylspermidine amidase activity
pBML2531_RS01795	COG3384	dioxygenase
pBML2531_RS01800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
pBML2531_RS01815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
pBML2531_RS01815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
pBML2531_RS01820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
pBML2531_RS01825	COG3025	triphosphatase activity
pBML2531_RS01830	COG4991	sh3 domain protein
pBML2531_RS01835	COG0617	tRNA 3'-terminal CCA addition
pBML2531_RS01840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
pBML2531_RS01845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
pBML2531_RS01850	COG0840	transmembrane signaling receptor activity
pBML2531_RS01855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
pBML2531_RS01860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
pBML2531_RS01865	COG0358	DNA primase activity
pBML2531_RS01880	COG2814	Major facilitator Superfamily
pBML2531_RS01895	COG2271	Major facilitator Superfamily
pBML2531_RS01905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
pBML2531_RS01930	COG2226	methyltransferase
pBML2531_RS01980	COG1124	(ABC) transporter
pBML2531_RS01990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
pBML2531_RS02030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
pBML2531_RS02035	COG0830	nickel cation binding
pBML2531_RS02045	COG0309	Hydrogenase expression formation protein (HypE)
pBML2531_RS02050	COG0409	Hydrogenase expression formation protein
pBML2531_RS02055	COG0298	carbon dioxide binding
pBML2531_RS02060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
pBML2531_RS02070	COG1773	rubredoxin
pBML2531_RS02075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
pBML2531_RS02080	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
pBML2531_RS02085	COG5557	Pfam Polysulphide reductase, NrfD
pBML2531_RS02090	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS02095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
pBML2531_RS02100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
pBML2531_RS02110	COG2146	nitrite reductase [NAD(P)H] activity
pBML2531_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS02130	COG1414	Transcriptional regulator
pBML2531_RS02145	COG2271	Major facilitator Superfamily
pBML2531_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS02165	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
pBML2531_RS02170	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS02180	COG0590	tRNA wobble adenosine to inosine editing
pBML2531_RS02250	COG3501	Rhs element vgr protein
pBML2531_RS02280	COG0446	pyridine nucleotide-disulphide oxidoreductase
pBML2531_RS02280	COG1902	pentaerythritol trinitrate reductase activity
pBML2531_RS02285	COG1469	GTP cyclohydrolase I activity
pBML2531_RS02295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
pBML2531_RS02300	COG0861	Integral membrane protein TerC family
pBML2531_RS02305	COG0586	Pfam SNARE associated Golgi protein
pBML2531_RS02310	COG4575	ribosome binding
pBML2531_RS02315	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
pBML2531_RS02325	COG2259	Doxx family
pBML2531_RS02330	COG0583	DNA-binding transcription factor activity
pBML2531_RS02335	COG1741	Belongs to the pirin family
pBML2531_RS02340	COG3711	transcriptional antiterminator
pBML2531_RS02340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS02370	COG3964	amidohydrolase
pBML2531_RS02385	COG0348	domain, Protein
pBML2531_RS02395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
pBML2531_RS02405	COG0792	nuclease activity
pBML2531_RS02410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
pBML2531_RS02415	COG2823	Periplasmic or secreted lipoprotein
pBML2531_RS02420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
pBML2531_RS02425	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
pBML2531_RS02430	COG0784	Response regulator, receiver
pBML2531_RS02430	COG2198	Histidine kinase
pBML2531_RS02430	COG5002	protein histidine kinase activity
pBML2531_RS02435	COG0493	'glutamate synthase
pBML2531_RS02440	COG2969	positive regulation of protein catabolic process
pBML2531_RS02445	COG0625	glutathione transferase activity
pBML2531_RS02450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
pBML2531_RS02455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
pBML2531_RS02460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
pBML2531_RS02465	COG3105	Protein conserved in bacteria
pBML2531_RS02470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
pBML2531_RS02475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
pBML2531_RS02480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
pBML2531_RS02485	COG5007	Belongs to the BolA IbaG family
pBML2531_RS02495	COG2854	intermembrane phospholipid transfer
pBML2531_RS02500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
pBML2531_RS02505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
pBML2531_RS02510	COG1127	ABC transporter
pBML2531_RS02515	COG0517	IMP dehydrogenase activity
pBML2531_RS02515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
pBML2531_RS02520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
pBML2531_RS02525	COG3117	lipopolysaccharide transmembrane transporter activity
pBML2531_RS02530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
pBML2531_RS02535	COG1137	ATPase activity
pBML2531_RS02540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
pBML2531_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
pBML2531_RS02555	COG1660	Displays ATPase and GTPase activities
pBML2531_RS02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS02565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
pBML2531_RS02570	COG0312	modulator of DNA gyrase
pBML2531_RS02575	COG3028	Belongs to the UPF0307 family
pBML2531_RS02595	COG2732	(Barnase) inhibitor
pBML2531_RS02605	COG0312	modulator of DNA gyrase
pBML2531_RS02610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
pBML2531_RS02615	COG3164	Protein of unknown function
pBML2531_RS02620	COG1530	ribonuclease E activity
pBML2531_RS02625	COG0424	maF-like protein
pBML2531_RS02630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
pBML2531_RS02635	COG1792	Involved in formation and maintenance of cell shape
pBML2531_RS02640	COG1077	Cell shape determining protein MreB Mrl
pBML2531_RS02645	COG0604	alcohol dehydrogenase
pBML2531_RS02650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
pBML2531_RS02655	COG0511	ligase activity, forming carbon-carbon bonds
pBML2531_RS02660	COG0439	Biotin carboxylase
pBML2531_RS02665	COG3924	membrane
pBML2531_RS02670	COG4145	pantothenate transmembrane transporter activity
pBML2531_RS02675	COG2264	protein methyltransferase activity
pBML2531_RS02680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
pBML2531_RS02685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
pBML2531_RS02690	COG0840	transmembrane signaling receptor activity
pBML2531_RS02695	COG4771	TonB-dependent receptor
pBML2531_RS02705	COG0814	amino acid
pBML2531_RS02755	COG2086	electron transfer activity
pBML2531_RS02760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
pBML2531_RS02765	COG1960	acyl-CoA dehydrogenase activity
pBML2531_RS02775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
pBML2531_RS02795	COG4177	L-phenylalanine transmembrane transporter activity
pBML2531_RS02800	COG0559	Belongs to the binding-protein-dependent transport system permease family
pBML2531_RS02805	COG0683	leucine binding
pBML2531_RS02810	COG0456	acetyltransferase
pBML2531_RS02815	COG0346	lactoylglutathione lyase activity
pBML2531_RS02825	COG2177	Part of the ABC transporter FtsEX involved in
pBML2531_RS02830	COG2884	Cell division ATP-binding protein ftsE
pBML2531_RS02835	COG0552	protein localization to endoplasmic reticulum
pBML2531_RS02835	COG0552	protein localization to endoplasmic reticulum
pBML2531_RS02840	COG0742	ribosomal rna small subunit methyltransferase
pBML2531_RS02845	COG3776	membrane
pBML2531_RS02855	COG3714	YhhN family
pBML2531_RS02865	COG5464	transposase or invertase
pBML2531_RS02875	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
pBML2531_RS02880	COG0247	lactate metabolic process
pBML2531_RS02890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
pBML2531_RS02895	COG2271	Major facilitator Superfamily
pBML2531_RS02900	COG0584	glycerophosphoryl diester phosphodiesterase
pBML2531_RS02910	COG1053	succinate dehydrogenase
pBML2531_RS02915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
pBML2531_RS02920	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
pBML2531_RS02925	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
pBML2531_RS02940	COG0477	Major facilitator Superfamily
pBML2531_RS02955	COG0477	Major facilitator Superfamily
pBML2531_RS02965	COG3423	Transcriptional regulator
pBML2531_RS02970	COG2076	Multidrug Resistance protein
pBML2531_RS02980	COG1966	Carbon starvation protein
pBML2531_RS02985	COG2879	small protein
pBML2531_RS02990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
pBML2531_RS02995	COG1509	lysine 2,3-aminomutase activity
pBML2531_RS03020	COG1027	Aspartate ammonia-lyase
pBML2531_RS03025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
pBML2531_RS03035	COG1309	transcriptional regulator
pBML2531_RS03055	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
pBML2531_RS03065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
pBML2531_RS03070	COG2731	YhcH YjgK YiaL family protein
pBML2531_RS03075	COG1737	Transcriptional regulator
pBML2531_RS03085	COG0500	methyltransferase
pBML2531_RS03100	COG2197	response regulator
pBML2531_RS03115	COG3188	usher protein
pBML2531_RS03135	COG3188	usher protein
pBML2531_RS03140	COG3121	Chaperone
pBML2531_RS03155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
pBML2531_RS03170	COG2207	Transcriptional regulator
pBML2531_RS03170	COG3708	Transcriptional regulator
pBML2531_RS03180	COG3609	addiction module antidote protein, CC2985 family
pBML2531_RS03185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
pBML2531_RS03185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
pBML2531_RS03205	COG4869	propanediol catabolic process
pBML2531_RS03215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
pBML2531_RS03220	COG1882	Formate acetyltransferase
pBML2531_RS03235	COG1454	alcohol dehydrogenase
pBML2531_RS03235	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS03260	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS03280	COG1177	transmembrane transport
pBML2531_RS03295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
pBML2531_RS03295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
pBML2531_RS03310	COG3121	Chaperone
pBML2531_RS03315	COG3188	usher protein
pBML2531_RS03335	COG0583	DNA-binding transcription factor activity
pBML2531_RS03355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
pBML2531_RS03360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
pBML2531_RS03385	COG3239	Fatty acid desaturase
pBML2531_RS03390	COG0726	polysaccharide deacetylase
pBML2531_RS03400	COG2271	Major facilitator Superfamily
pBML2531_RS03415	COG2721	sulfolactate sulfo-lyase activity
pBML2531_RS03430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS03430	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS03440	COG3716	PTS system mannose fructose sorbose family IID component
pBML2531_RS03455	COG1349	DNA-binding transcription factor activity
pBML2531_RS03465	COG1129	ABC transporter
pBML2531_RS03470	COG1172	Belongs to the binding-protein-dependent transport system permease family
pBML2531_RS03475	COG1172	Belongs to the binding-protein-dependent transport system permease family
pBML2531_RS03480	COG3623	hexulose-6-phosphate isomerase
pBML2531_RS03485	COG1070	Carbohydrate kinase
pBML2531_RS03490	COG2194	sulfuric ester hydrolase activity
pBML2531_RS03500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS03505	COG2814	Major facilitator Superfamily
pBML2531_RS03510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
pBML2531_RS03520	COG1609	Transcriptional regulator
pBML2531_RS03525	COG0583	DNA-binding transcription factor activity
pBML2531_RS03530	COG2610	gluconate transmembrane transporter activity
pBML2531_RS03535	COG3048	D-serine ammonia-lyase activity
pBML2531_RS03540	COG1363	Peptidase, m42
pBML2531_RS03545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
pBML2531_RS03555	COG0444	Belongs to the ABC transporter superfamily
pBML2531_RS03565	COG0747	negative chemotaxis
pBML2531_RS03575	COG3573	Dehydrogenase
pBML2531_RS03595	COG0318	PFAM AMP-dependent synthetase and ligase
pBML2531_RS03600	COG0625	glutathione transferase activity
pBML2531_RS03610	COG1840	ABC-type Fe3 transport system, periplasmic component
pBML2531_RS03615	COG3842	ATPase activity
pBML2531_RS03620	COG0318	PFAM AMP-dependent synthetase and ligase
pBML2531_RS03620	COG0204	Acyl-transferase
pBML2531_RS03625	COG1858	cytochrome C peroxidase
pBML2531_RS03630	COG2211	Major facilitator Superfamily
pBML2531_RS03635	COG1397	ADP-ribosylglycohydrolase
pBML2531_RS03640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS03645	COG2188	Transcriptional regulator
pBML2531_RS03655	COG3302	dmso reductase anchor subunit
pBML2531_RS03660	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS03665	COG0243	molybdopterin cofactor binding
pBML2531_RS03685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
pBML2531_RS03690	COG1538	Outer membrane efflux protein
pBML2531_RS03695	COG0577	efflux transmembrane transporter activity
pBML2531_RS03695	COG1136	(ABC) transporter
pBML2531_RS03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
pBML2531_RS03705	COG1132	(ABC) transporter
pBML2531_RS03735	COG3539	Fimbrial protein
pBML2531_RS03745	COG3121	Chaperone
pBML2531_RS03750	COG3188	usher protein
pBML2531_RS03760	COG3539	Fimbrial protein
pBML2531_RS03780	COG2205	protein histidine kinase activity
pBML2531_RS03785	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS03790	COG0582	viral genome integration into host DNA
pBML2531_RS03800	COG1396	sequence-specific DNA binding
pBML2531_RS03815	COG3188	usher protein
pBML2531_RS03820	COG3121	Chaperone
pBML2531_RS03865	COG3069	C4-dicarboxylate transmembrane transporter activity
pBML2531_RS03870	COG1473	amidohydrolase
pBML2531_RS03890	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
pBML2531_RS03900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
pBML2531_RS03915	COG1070	Carbohydrate kinase
pBML2531_RS03920	COG4806	L-rhamnose isomerase
pBML2531_RS03935	COG1454	alcohol dehydrogenase
pBML2531_RS03940	COG3254	rhamnose metabolic process
pBML2531_RS03945	COG1917	Cupin 2, conserved barrel domain protein
pBML2531_RS03945	COG4977	sequence-specific DNA binding
pBML2531_RS03950	COG4977	sequence-specific DNA binding
pBML2531_RS03960	COG3121	Chaperone
pBML2531_RS03965	COG3188	usher protein
pBML2531_RS03975	COG3069	C4-dicarboxylate transmembrane transporter activity
pBML2531_RS03995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
pBML2531_RS04000	COG0583	DNA-binding transcription factor activity
pBML2531_RS04050	COG3157	Type VI secretion system effector, Hcp
pBML2531_RS04070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
pBML2531_RS04085	COG0795	lipopolysaccharide-transporting ATPase activity
pBML2531_RS04090	COG0795	lipopolysaccharide-transporting ATPase activity
pBML2531_RS04095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
pBML2531_RS04100	COG2927	DNA polymerase III (CHI subunit)
pBML2531_RS04105	COG0525	valine-tRNA ligase activity
pBML2531_RS04120	COG1285	pathogenesis
pBML2531_RS04125	COG2211	Major facilitator Superfamily
pBML2531_RS04135	COG1609	Transcriptional regulator
pBML2531_RS04140	COG1085	galactose-1-phosphate uridylyltransferase
pBML2531_RS04160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
pBML2531_RS04175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
pBML2531_RS04185	COG2188	Transcriptional regulator
pBML2531_RS04215	COG0540	Belongs to the ATCase OTCase family
pBML2531_RS04220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
pBML2531_RS04225	COG0251	oxidation-reduction process
pBML2531_RS04230	COG1328	CTP reductase activity
pBML2531_RS04235	COG0602	queuosine metabolic process
pBML2531_RS04240	COG3787	Belongs to the UPF0306 family
pBML2531_RS04250	COG2827	Endonuclease containing a URI domain
pBML2531_RS04255	COG3153	acetyltransferase
pBML2531_RS04260	COG3154	lipid carrier protein
pBML2531_RS04265	COG0826	peptidase U32
pBML2531_RS04270	COG0826	peptidase U32
pBML2531_RS04280	COG3077	Addiction module antitoxin, RelB DinJ family
pBML2531_RS04300	COG3275	phosphorelay sensor kinase activity
pBML2531_RS04320	COG0513	Belongs to the DEAD box helicase family
pBML2531_RS04340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
pBML2531_RS04345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
pBML2531_RS04350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
pBML2531_RS04355	COG0195	Participates in both transcription termination and antitermination
pBML2531_RS04360	COG0779	Required for maturation of 30S ribosomal subunits
pBML2531_RS04375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
pBML2531_RS04380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
pBML2531_RS04385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
pBML2531_RS04390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
pBML2531_RS04395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
pBML2531_RS04400	COG1534	Rna-binding protein
pBML2531_RS04410	COG2027	D-alanyl-D-alanine carboxypeptidase
pBML2531_RS04415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
pBML2531_RS04420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
pBML2531_RS04425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
pBML2531_RS04430	COG0142	geranyltranstransferase activity
pBML2531_RS04445	COG3423	Transcriptional regulator
pBML2531_RS04450	COG0039	L-malate dehydrogenase activity
pBML2531_RS04455	COG1438	arginine binding
pBML2531_RS04465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
pBML2531_RS04470	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
pBML2531_RS04480	COG2105	PFAM AIG2 family protein
pBML2531_RS04485	COG2911	Protein conserved in bacteria
pBML2531_RS04490	COG0729	surface antigen
pBML2531_RS04495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
pBML2531_RS04500	COG1253	flavin adenine dinucleotide binding
pBML2531_RS04510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
pBML2531_RS04515	COG0642	Histidine kinase
pBML2531_RS04525	COG3111	PFAM Bacterial OB fold (BOF) protein
pBML2531_RS04530	COG0494	nUDIX hydrolase
pBML2531_RS04540	COG0579	oxidoreductase
pBML2531_RS04550	COG0545	Peptidyl-prolyl cis-trans isomerase
pBML2531_RS04555	COG3061	Opacity-associated protein A
pBML2531_RS04565	COG0359	binds to the 23S rRNA
pBML2531_RS04570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
pBML2531_RS04575	COG2965	DNA replication, synthesis of RNA primer
pBML2531_RS04580	COG0360	Binds together with S18 to 16S ribosomal RNA
pBML2531_RS04585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
pBML2531_RS04590	COG0557	exoribonuclease II activity
pBML2531_RS04595	COG1959	2 iron, 2 sulfur cluster binding
pBML2531_RS04600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
pBML2531_RS04605	COG0330	HflC and HflK could
pBML2531_RS04610	COG0330	HflC and HflK could
pBML2531_RS04615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
pBML2531_RS04620	COG1923	regulation of RNA biosynthetic process
pBML2531_RS04625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
pBML2531_RS04630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
pBML2531_RS04640	COG0802	atpase or kinase
pBML2531_RS04645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
pBML2531_RS04670	COG1162	GTPase activity
pBML2531_RS04675	COG0688	phosphatidylethanolamine metabolic process
pBML2531_RS04680	COG1511	domain protein
pBML2531_RS04680	COG3264	Mechanosensitive ion channel
pBML2531_RS04695	COG0561	phosphatase activity
pBML2531_RS04700	COG2267	carboxylic ester hydrolase activity
pBML2531_RS04715	COG2050	protein possibly involved in aromatic compounds catabolism
pBML2531_RS04725	COG0531	amino acid
pBML2531_RS04740	COG1690	Belongs to the RtcB family
pBML2531_RS04745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
pBML2531_RS04765	COG0210	DNA helicase
pBML2531_RS04770	COG1011	Hydrolase
pBML2531_RS04785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
pBML2531_RS04790	COG5567	small periplasmic lipoprotein
pBML2531_RS04795	COG1965	Belongs to the frataxin family
pBML2531_RS04815	COG2959	enzyme of heme biosynthesis
pBML2531_RS04820	COG3071	HemY protein
pBML2531_RS04855	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
pBML2531_RS04865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
pBML2531_RS04870	COG2244	polysaccharide biosynthetic process
pBML2531_RS04875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
pBML2531_RS04885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
pBML2531_RS04890	COG1088	dTDP-glucose 4,6-dehydratase activity
pBML2531_RS04895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
pBML2531_RS04900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
pBML2531_RS04905	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
pBML2531_RS04910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
pBML2531_RS04915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
pBML2531_RS04920	COG3118	belongs to the thioredoxin family
pBML2531_RS04925	COG0513	Belongs to the DEAD box helicase family
pBML2531_RS04935	COG0210	DNA helicase
pBML2531_RS04940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
pBML2531_RS04955	COG0129	dihydroxy-acid dehydratase activity
pBML2531_RS04965	COG3978	acetolactate synthase activity
pBML2531_RS04980	COG0606	chelatase, subunit chli
pBML2531_RS04985	COG3085	chromosome segregation
pBML2531_RS04990	COG0583	DNA-binding transcription factor activity
pBML2531_RS05025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
pBML2531_RS05030	COG4206	TonB-dependent receptor
pBML2531_RS05035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
pBML2531_RS05050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
pBML2531_RS05070	COG0165	Argininosuccinate lyase
pBML2531_RS05075	COG0137	argininosuccinate synthase activity
pBML2531_RS05080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
pBML2531_RS05085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
pBML2531_RS05090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
pBML2531_RS05095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
pBML2531_RS05100	COG0076	glutamate decarboxylase activity
pBML2531_RS05105	COG0531	amino acid
pBML2531_RS05110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
pBML2531_RS05120	COG0460	homoserine dehydrogenase
pBML2531_RS05120	COG0527	aspartate kinase activity
pBML2531_RS05125	COG0626	cystathionine gamma-synthase activity
pBML2531_RS05140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
pBML2531_RS05145	COG1609	Transcriptional regulator
pBML2531_RS05150	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
pBML2531_RS05155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
pBML2531_RS05160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
pBML2531_RS05165	COG1575	Belongs to the MenA family. Type 1 subfamily
pBML2531_RS05170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
pBML2531_RS05175	COG3074	FtsZ-dependent cytokinesis
pBML2531_RS05185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
pBML2531_RS05195	COG2814	Major facilitator Superfamily
pBML2531_RS05205	COG3152	Membrane
pBML2531_RS05215	COG0149	triose-phosphate isomerase activity
pBML2531_RS05225	COG1472	Belongs to the glycosyl hydrolase 3 family
pBML2531_RS05240	COG0205	6-phosphofructokinase activity
pBML2531_RS05245	COG4589	Belongs to the CDS family
pBML2531_RS05255	COG0501	Belongs to the peptidase M48B family
pBML2531_RS05265	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
pBML2531_RS05275	COG3678	ATP-independent chaperone mediated protein folding
pBML2531_RS05280	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS05285	COG2205	protein histidine kinase activity
pBML2531_RS05300	COG1442	glycosyl transferase family 8
pBML2531_RS05300	COG1216	Glycosyl transferase, family 2
pBML2531_RS05310	COG0438	transferase activity, transferring glycosyl groups
pBML2531_RS05310	COG0297	glycogen (starch) synthase activity
pBML2531_RS05330	COG1215	transferase activity, transferring glycosyl groups
pBML2531_RS05335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
pBML2531_RS05340	COG1596	polysaccharide export
pBML2531_RS05345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
pBML2531_RS05350	COG3206	protein involved in exopolysaccharide biosynthesis
pBML2531_RS05350	COG0489	protein tyrosine kinase activity
pBML2531_RS05355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
pBML2531_RS05360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
pBML2531_RS05365	COG2337	Toxic component of a toxin-antitoxin (TA) module
pBML2531_RS05375	COG1045	serine acetyltransferase
pBML2531_RS05380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
pBML2531_RS05390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
pBML2531_RS05395	COG4942	peptidase
pBML2531_RS05400	COG2861	carbohydrate metabolic process
pBML2531_RS05405	COG1063	alcohol dehydrogenase
pBML2531_RS05410	COG0156	8-amino-7-oxononanoate synthase activity
pBML2531_RS05415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
pBML2531_RS05425	COG0859	PFAM glycosyl transferase family 9
pBML2531_RS05440	COG1519	Transferase
pBML2531_RS05445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
pBML2531_RS05450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
pBML2531_RS05475	COG0515	serine threonine protein kinase
pBML2531_RS05480	COG0438	transferase activity, transferring glycosyl groups
pBML2531_RS05485	COG0859	PFAM glycosyl transferase family 9
pBML2531_RS05495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
pBML2531_RS05505	COG2003	Belongs to the UPF0758 family
pBML2531_RS05510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
pBML2531_RS05515	COG0756	dUTP diphosphatase activity
pBML2531_RS05520	COG1309	transcriptional regulator
pBML2531_RS05525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
pBML2531_RS05530	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
pBML2531_RS05535	COG1561	YicC-like family, N-terminal region
pBML2531_RS05540	COG2271	Major facilitator Superfamily
pBML2531_RS05545	COG0473	3-isopropylmalate dehydrogenase activity
pBML2531_RS05545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
pBML2531_RS05550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
pBML2531_RS05560	COG2211	Major facilitator Superfamily
pBML2531_RS05575	COG1940	carbohydrate kinase activity
pBML2531_RS05575	COG1846	Transcriptional regulator
pBML2531_RS05585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
pBML2531_RS05600	COG1368	sulfuric ester hydrolase activity
pBML2531_RS05605	COG3276	selenocysteine insertion sequence binding
pBML2531_RS05610	COG1921	L-seryl-tRNASec selenium transferase activity
pBML2531_RS05615	COG3058	Necessary for formate dehydrogenase activity
pBML2531_RS05635	COG1312	Catalyzes the dehydration of D-mannonate
pBML2531_RS05640	COG2186	Transcriptional regulator
pBML2531_RS05645	COG4948	Mandelate Racemase Muconate Lactonizing
pBML2531_RS05650	COG1063	alcohol dehydrogenase
pBML2531_RS05655	COG0477	Major facilitator Superfamily
pBML2531_RS05660	COG0246	Mannitol dehydrogenase
pBML2531_RS05675	COG0679	Auxin Efflux Carrier
pBML2531_RS05680	COG0028	Belongs to the TPP enzyme family
pBML2531_RS05690	COG2864	formate dehydrogenase
pBML2531_RS05695	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS05705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
pBML2531_RS05710	COG3550	peptidyl-serine autophosphorylation
pBML2531_RS05720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
pBML2531_RS05725	COG0706	membrane insertase activity
pBML2531_RS05730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
pBML2531_RS05735	COG0594	ribonuclease P activity
pBML2531_RS05740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
pBML2531_RS05745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
pBML2531_RS05750	COG0592	DNA-directed DNA polymerase activity
pBML2531_RS05755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
pBML2531_RS05760	COG0187	DNA topoisomerase II activity
pBML2531_RS05770	COG2194	sulfuric ester hydrolase activity
pBML2531_RS05780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
pBML2531_RS05785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
pBML2531_RS05790	COG0254	rRNA binding
pBML2531_RS05800	COG1940	carbohydrate kinase activity
pBML2531_RS05860	COG4264	IucA IucC family
pBML2531_RS05865	COG4774	siderophore transport
pBML2531_RS05870	COG0019	diaminopimelate decarboxylase activity
pBML2531_RS05875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
pBML2531_RS05880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
pBML2531_RS05885	COG2814	Major facilitator Superfamily
pBML2531_RS05970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
pBML2531_RS05975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
pBML2531_RS05980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
pBML2531_RS05985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
pBML2531_RS05990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
pBML2531_RS05995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
pBML2531_RS06000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
pBML2531_RS06015	COG0356	it plays a direct role in the translocation of protons across the membrane
pBML2531_RS06020	COG3312	ion transport
pBML2531_RS06025	COG0357	Ribosomal RNA small subunit methyltransferase G
pBML2531_RS06030	COG0445	tRNA wobble uridine modification
pBML2531_RS06035	COG0716	FMN binding
pBML2531_RS06040	COG1522	sequence-specific DNA binding
pBML2531_RS06045	COG2502	aspartate--ammonia ligase
pBML2531_RS06050	COG2425	protein containing a von Willebrand factor type A (vWA) domain
pBML2531_RS06055	COG0714	Associated with various cellular activities
pBML2531_RS06065	COG1129	ABC transporter
pBML2531_RS06070	COG1172	Belongs to the binding-protein-dependent transport system permease family
pBML2531_RS06080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS06085	COG1609	Transcriptional regulator
pBML2531_RS06090	COG0477	Major facilitator Superfamily
pBML2531_RS06095	COG2186	Transcriptional regulator
pBML2531_RS06135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
pBML2531_RS06145	COG1072	(Pantothenic acid kinase))
pBML2531_RS06185	COG0051	transcription antitermination factor activity, RNA binding
pBML2531_RS06190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
pBML2531_RS06195	COG0088	Forms part of the polypeptide exit tunnel
pBML2531_RS06200	COG0089	rRNA binding
pBML2531_RS06205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
pBML2531_RS06215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
pBML2531_RS06225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
pBML2531_RS06235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
pBML2531_RS06240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
pBML2531_RS06245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
pBML2531_RS06250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
pBML2531_RS06255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
pBML2531_RS06260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
pBML2531_RS06265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
pBML2531_RS06270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
pBML2531_RS06275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
pBML2531_RS06280	COG1841	ribosomal large subunit assembly
pBML2531_RS06285	COG0200	Binds to the 23S rRNA
pBML2531_RS06290	COG0201	protein transport
pBML2531_RS06295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
pBML2531_RS06300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
pBML2531_RS06310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
pBML2531_RS06325	COG0789	Transcriptional regulator
pBML2531_RS06330	COG3036	rescue of stalled ribosome
pBML2531_RS06340	COG0569	domain protein
pBML2531_RS06350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
pBML2531_RS06360	COG0758	DNA mediated transformation
pBML2531_RS06365	COG0551	DNA topoisomerase type I activity
pBML2531_RS06370	COG0009	L-threonylcarbamoyladenylate synthase
pBML2531_RS06375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
pBML2531_RS06385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
pBML2531_RS06415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
pBML2531_RS06420	COG3162	membrane
pBML2531_RS06425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
pBML2531_RS06430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
pBML2531_RS06435	COG0443	Heat shock 70 kDa protein
pBML2531_RS06445	COG2258	MOSC domain
pBML2531_RS06470	COG1335	isochorismatase
pBML2531_RS06475	COG2353	YceI-like domain
pBML2531_RS06480	COG1304	FMN binding
pBML2531_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS06490	COG0180	Tryptophanyl-tRNA synthetase
pBML2531_RS06495	COG0546	phosphoglycolate phosphatase activity
pBML2531_RS06500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
pBML2531_RS06515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
pBML2531_RS06520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
pBML2531_RS06525	COG4796	Type ii and iii secretion system protein
pBML2531_RS06545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
pBML2531_RS06550	COG0494	nUDIX hydrolase
pBML2531_RS06560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
pBML2531_RS06565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
pBML2531_RS06570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
pBML2531_RS06575	COG1741	Belongs to the pirin family
pBML2531_RS06580	COG2081	HI0933 family
pBML2531_RS06585	COG0306	phosphate transporter
pBML2531_RS06595	COG0589	response to stress
pBML2531_RS06600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
pBML2531_RS06605	COG0742	ribosomal rna small subunit methyltransferase
pBML2531_RS06655	COG3122	Protein conserved in bacteria
pBML2531_RS06665	COG1278	Cold shock
pBML2531_RS06670	COG1737	Transcriptional regulator
pBML2531_RS06675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS06675	COG1263	PTS System
pBML2531_RS06680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
pBML2531_RS06845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
pBML2531_RS06850	COG0477	Major facilitator Superfamily
pBML2531_RS06865	COG0402	S-adenosylhomocysteine deaminase activity
pBML2531_RS06870	COG0549	Belongs to the carbamate kinase family
pBML2531_RS06880	COG1304	FMN binding
pBML2531_RS06885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
pBML2531_RS06895	COG0666	response to abiotic stimulus
pBML2531_RS06900	COG0583	DNA-binding transcription factor activity
pBML2531_RS06905	COG2819	hydrolase of the alpha beta superfamily
pBML2531_RS06910	COG4771	TonB-dependent receptor
pBML2531_RS06915	COG1566	PFAM secretion protein HlyD family protein
pBML2531_RS06920	COG2814	Major facilitator Superfamily
pBML2531_RS06925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
pBML2531_RS06930	COG3327	negative regulation of DNA-templated transcription, initiation
pBML2531_RS06935	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
pBML2531_RS06940	COG0183	Belongs to the thiolase family
pBML2531_RS06945	COG2050	protein possibly involved in aromatic compounds catabolism
pBML2531_RS06950	COG1250	3-hydroxyacyl-CoA dehydrogenase
pBML2531_RS06955	COG1024	Enoyl-CoA hydratase
pBML2531_RS06960	COG1024	Enoyl-CoA hydratase
pBML2531_RS06965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
pBML2531_RS06970	COG2151	metal-sulfur cluster biosynthetic enzyme
pBML2531_RS06975	COG3396	Phenylacetate-CoA oxygenase
pBML2531_RS06980	COG3460	Phenylacetate-CoA oxygenase
pBML2531_RS06985	COG3396	Phenylacetate-CoA oxygenase
pBML2531_RS06990	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS06990	COG2030	dehydratase
pBML2531_RS06995	COG2226	methyltransferase
pBML2531_RS07010	COG0477	Major facilitator Superfamily
pBML2531_RS07015	COG0028	Belongs to the TPP enzyme family
pBML2531_RS07020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
pBML2531_RS07030	COG3189	MarR family transcriptional regulator
pBML2531_RS07045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
pBML2531_RS07050	COG1349	DNA-binding transcription factor activity
pBML2531_RS07055	COG0705	Rhomboid family
pBML2531_RS07060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
pBML2531_RS07065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
pBML2531_RS07065	COG0316	Belongs to the HesB IscA family
pBML2531_RS07075	COG2267	carboxylic ester hydrolase activity
pBML2531_RS07090	COG1918	ferrous iron import across plasma membrane
pBML2531_RS07095	COG2183	response to ionizing radiation
pBML2531_RS07100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
pBML2531_RS07110	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS07115	COG2205	protein histidine kinase activity
pBML2531_RS07120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
pBML2531_RS07125	COG0573	inorganic phosphate transmembrane transporter activity
pBML2531_RS07130	COG0581	inorganic phosphate transmembrane transporter activity
pBML2531_RS07140	COG0704	Plays a role in the regulation of phosphate uptake
pBML2531_RS07145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
pBML2531_RS07155	COG0765	amino acid transport
pBML2531_RS07160	COG2252	PERMEase
pBML2531_RS07170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
pBML2531_RS07210	COG3539	Fimbrial protein
pBML2531_RS07215	COG3539	Fimbrial protein
pBML2531_RS07250	COG1695	Transcriptional regulator
pBML2531_RS07265	COG1011	Hydrolase
pBML2531_RS07275	COG0456	acetyltransferase
pBML2531_RS07280	COG2982	Protein involved in outer membrane biogenesis
pBML2531_RS07285	COG2233	PERMEase
pBML2531_RS07290	COG0786	glutamate:sodium symporter activity
pBML2531_RS07295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
pBML2531_RS07300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
pBML2531_RS07305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
pBML2531_RS07310	COG1758	RNA polymerase activity
pBML2531_RS07320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
pBML2531_RS07325	COG2860	membrane
pBML2531_RS07330	COG0823	Involved in the tonB-independent uptake of proteins
pBML2531_RS07335	COG5645	(Lipo)protein
pBML2531_RS07345	COG3977	Valine--pyruvate aminotransferase
pBML2531_RS07350	COG2818	Glycosylase
pBML2531_RS07360	COG0751	glycine-tRNA ligase activity
pBML2531_RS07370	COG2831	hemolysin activation secretion protein
pBML2531_RS07375	COG0747	negative chemotaxis
pBML2531_RS07380	COG0601	transmembrane transport
pBML2531_RS07385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
pBML2531_RS07390	COG0444	Belongs to the ABC transporter superfamily
pBML2531_RS07395	COG4608	Belongs to the ABC transporter superfamily
pBML2531_RS07405	COG0612	Peptidase, M16
pBML2531_RS07410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
pBML2531_RS07420	COG1295	ribonuclease BN
pBML2531_RS07430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
pBML2531_RS07435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
pBML2531_RS07445	COG2378	regulation of single-species biofilm formation
pBML2531_RS07455	COG2723	6-phospho-beta-galactosidase activity
pBML2531_RS07470	COG1763	Mo-molybdopterin cofactor biosynthetic process
pBML2531_RS07475	COG0746	molybdenum cofactor guanylyltransferase activity
pBML2531_RS07480	COG3084	Protein conserved in bacteria
pBML2531_RS07485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
pBML2531_RS07490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
pBML2531_RS07495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
pBML2531_RS07495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
pBML2531_RS07500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
pBML2531_RS07525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
pBML2531_RS07530	COG1765	OsmC-like protein
pBML2531_RS07535	COG3954	Phosphoribulokinase
pBML2531_RS07545	COG0429	hydrolase of the alpha beta-hydrolase fold
pBML2531_RS07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS07565	COG1263	PTS System
pBML2531_RS07570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
pBML2531_RS07580	COG1982	Orn Lys Arg decarboxylase major
pBML2531_RS07585	COG0488	(ABC) transporter
pBML2531_RS07590	COG2249	NAD(P)H dehydrogenase (quinone) activity
pBML2531_RS07600	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
pBML2531_RS07605	COG1047	Peptidyl-prolyl cis-trans
pBML2531_RS07610	COG2900	Belongs to the SlyX family
pBML2531_RS07615	COG0545	Peptidyl-prolyl cis-trans isomerase
pBML2531_RS07620	COG2964	Protein conserved in bacteria
pBML2531_RS07625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
pBML2531_RS07640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
pBML2531_RS07645	COG0049	tRNA binding
pBML2531_RS07650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
pBML2531_RS07665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
pBML2531_RS07670	COG0250	Participates in transcription elongation, termination and antitermination
pBML2531_RS07675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
pBML2531_RS07685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
pBML2531_RS07690	COG0222	ribosome binding
pBML2531_RS07695	COG0085	RNA polymerase activity
pBML2531_RS07700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
pBML2531_RS07710	COG3069	C4-dicarboxylate transmembrane transporter activity
pBML2531_RS07715	COG2195	Cleaves the N-terminal amino acid of tripeptides
pBML2531_RS07720	COG3119	arylsulfatase activity
pBML2531_RS07735	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS07745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
pBML2531_RS07750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS07750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS07755	COG3716	PTS system mannose fructose sorbose family IID component
pBML2531_RS07760	COG3715	PTS system
pBML2531_RS07765	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS07770	COG2222	sugar isomerase
pBML2531_RS07780	COG1349	DNA-binding transcription factor activity
pBML2531_RS07785	COG0641	radical SAM
pBML2531_RS07790	COG3119	arylsulfatase activity
pBML2531_RS07810	COG2233	PERMEase
pBML2531_RS07825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
pBML2531_RS07845	COG2022	thiamine diphosphate biosynthetic process
pBML2531_RS07850	COG2104	thiamine diphosphate biosynthetic process
pBML2531_RS07855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
pBML2531_RS07865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
pBML2531_RS07875	COG3842	ATPase activity
pBML2531_RS07880	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
pBML2531_RS07900	COG2816	NAD+ diphosphatase activity
pBML2531_RS07905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
pBML2531_RS07910	COG1515	deoxyribonuclease V activity
pBML2531_RS07915	COG3068	Protein conserved in bacteria
pBML2531_RS07930	COG0151	Belongs to the GarS family
pBML2531_RS07935	COG0138	bifunctional purine biosynthesis protein purh
pBML2531_RS07965	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
pBML2531_RS07970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
pBML2531_RS07980	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
pBML2531_RS07985	COG0800	Aldolase
pBML2531_RS07990	COG0129	dihydroxy-acid dehydratase activity
pBML2531_RS08005	COG3023	N-Acetylmuramoyl-L-alanine amidase
pBML2531_RS08010	COG1414	Transcriptional regulator
pBML2531_RS08015	COG1410	methionine synthase
pBML2531_RS08015	COG0646	methionine synthase
pBML2531_RS08030	COG0527	aspartate kinase activity
pBML2531_RS08035	COG0166	Belongs to the GPI family
pBML2531_RS08040	COG3161	chorismate lyase activity
pBML2531_RS08050	COG2937	Belongs to the GPAT DAPAT family
pBML2531_RS08055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
pBML2531_RS08065	COG0735	belongs to the Fur family
pBML2531_RS08075	COG3121	Chaperone
pBML2531_RS08105	COG3121	Chaperone
pBML2531_RS08110	COG1446	asparaginase
pBML2531_RS08130	COG0157	Belongs to the NadC ModD family
pBML2531_RS08135	COG0500	methyltransferase
pBML2531_RS08140	COG1120	ATPase activity
pBML2531_RS08155	COG1609	Transcriptional regulator
pBML2531_RS08160	COG3265	gluconokinase activity
pBML2531_RS08165	COG2610	gluconate transmembrane transporter activity
pBML2531_RS08225	COG2992	FlgJ-related protein
pBML2531_RS08255	COG2137	regulation of response to DNA damage stimulus
pBML2531_RS08265	COG3069	C4-dicarboxylate transmembrane transporter activity
pBML2531_RS08270	COG0814	amino acid
pBML2531_RS08275	COG2873	o-acetylhomoserine
pBML2531_RS08280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
pBML2531_RS08290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
pBML2531_RS08295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
pBML2531_RS08305	COG0789	Transcriptional regulator
pBML2531_RS08320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
pBML2531_RS08325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
pBML2531_RS08370	COG0179	Fumarylacetoacetate (FAA) hydrolase
pBML2531_RS08390	COG0025	NhaP-type Na H and K H
pBML2531_RS08455	COG0243	molybdopterin cofactor binding
pBML2531_RS08460	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS08470	COG3381	protein complex oligomerization
pBML2531_RS08490	COG3541	Predicted nucleotidyltransferase
pBML2531_RS08495	COG1690	Belongs to the RtcB family
pBML2531_RS08505	COG4650	regulator
pBML2531_RS08510	COG1388	LysM domain
pBML2531_RS08510	COG1470	cell adhesion involved in biofilm formation
pBML2531_RS08515	COG1470	cell adhesion involved in biofilm formation
pBML2531_RS08515	COG1388	LysM domain
pBML2531_RS08525	COG1349	DNA-binding transcription factor activity
pBML2531_RS08530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
pBML2531_RS08540	COG0738	Major facilitator superfamily
pBML2531_RS08555	COG0668	transmembrane transport
pBML2531_RS08560	COG1982	Orn Lys Arg decarboxylase major
pBML2531_RS08565	COG1957	nucleoside hydrolase
pBML2531_RS08575	COG0483	inositol monophosphate 1-phosphatase activity
pBML2531_RS08580	COG3196	Protein conserved in bacteria
pBML2531_RS08590	COG1335	isochorismatase
pBML2531_RS08595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
pBML2531_RS08610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
pBML2531_RS08620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
pBML2531_RS08635	COG2814	Major facilitator Superfamily
pBML2531_RS08645	COG0028	Belongs to the TPP enzyme family
pBML2531_RS08650	COG0440	acetolactate synthase activity
pBML2531_RS08655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
pBML2531_RS08680	COG2252	PERMEase
pBML2531_RS08685	COG0025	NhaP-type Na H and K H
pBML2531_RS08695	COG0583	DNA-binding transcription factor activity
pBML2531_RS08700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
pBML2531_RS08705	COG3753	Protein conserved in bacteria
pBML2531_RS08710	COG2084	Dehydrogenase
pBML2531_RS08715	COG3395	kinase activity
pBML2531_RS08720	COG0235	Class ii aldolase
pBML2531_RS08725	COG3622	Belongs to the hyi family
pBML2531_RS08730	COG1349	DNA-binding transcription factor activity
pBML2531_RS08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
pBML2531_RS08740	COG2610	gluconate transmembrane transporter activity
pBML2531_RS08745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
pBML2531_RS08755	COG0586	Pfam SNARE associated Golgi protein
pBML2531_RS08765	COG2226	methyltransferase
pBML2531_RS08770	COG3165	ubiquinone biosynthetic process from chorismate
pBML2531_RS08785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
pBML2531_RS08790	COG0805	protein transport
pBML2531_RS08805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
pBML2531_RS08815	COG0183	Belongs to the thiolase family
pBML2531_RS08820	COG1250	3-hydroxyacyl-CoA dehydrogenase
pBML2531_RS08820	COG1024	Enoyl-CoA hydratase
pBML2531_RS08830	COG0006	proline dipeptidase activity
pBML2531_RS08835	COG1739	Uncharacterized protein family UPF0029
pBML2531_RS08840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
pBML2531_RS08875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
pBML2531_RS08880	COG2197	response regulator
pBML2531_RS08885	COG3850	Histidine kinase
pBML2531_RS08890	COG2354	Protein conserved in bacteria
pBML2531_RS08895	COG1216	Glycosyl transferase, family 2
pBML2531_RS08910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
pBML2531_RS08920	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS08930	COG0531	amino acid
pBML2531_RS08945	COG1785	Belongs to the alkaline phosphatase family
pBML2531_RS08970	COG2813	Specifically methylates the guanine in position
pBML2531_RS08985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
pBML2531_RS08995	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS09010	COG0583	DNA-binding transcription factor activity
pBML2531_RS09015	COG0473	3-isopropylmalate dehydrogenase activity
pBML2531_RS09020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
pBML2531_RS09030	COG4667	esterase of the alpha-beta hydrolase superfamily
pBML2531_RS09035	COG0084	hydrolase, TatD family'
pBML2531_RS09050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
pBML2531_RS09055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
pBML2531_RS09060	COG0813	purine-nucleoside phosphorylase activity
pBML2531_RS09075	COG1247	-acetyltransferase
pBML2531_RS09085	COG0612	Peptidase, M16
pBML2531_RS09090	COG4178	(ABC) transporter
pBML2531_RS09095	COG4771	TonB-dependent receptor
pBML2531_RS09105	COG1595	DNA-templated transcription, initiation
pBML2531_RS09115	COG3726	membrane protein affecting hemolysin expression
pBML2531_RS09120	COG0560	Phosphoserine phosphatase
pBML2531_RS09125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
pBML2531_RS09135	COG0488	(ABC) transporter
pBML2531_RS09150	COG0741	lytic transglycosylase activity
pBML2531_RS09155	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
pBML2531_RS09160	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
pBML2531_RS09165	COG0406	alpha-ribazole phosphatase activity
pBML2531_RS09170	COG2207	Transcriptional regulator
pBML2531_RS09170	COG3708	Transcriptional regulator
pBML2531_RS09175	COG3045	CreA protein
pBML2531_RS09180	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS09195	COG0083	homoserine kinase activity
pBML2531_RS09225	COG5002	protein histidine kinase activity
pBML2531_RS09230	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS09260	COG0667	Aldo Keto reductase
pBML2531_RS09265	COG3022	response to hydroperoxide
pBML2531_RS09270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
pBML2531_RS09275	COG0521	Mo-molybdopterin cofactor biosynthetic process
pBML2531_RS09280	COG1584	GPR1 FUN34 yaaH family protein
pBML2531_RS09285	COG0443	Heat shock 70 kDa protein
pBML2531_RS09290	COG0484	heat shock protein binding
pBML2531_RS09295	COG0402	S-adenosylhomocysteine deaminase activity
pBML2531_RS09305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
pBML2531_RS09310	COG0583	DNA-binding transcription factor activity
pBML2531_RS09315	COG0268	Binds directly to 16S ribosomal RNA
pBML2531_RS09320	COG0196	riboflavin kinase activity
pBML2531_RS09325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
pBML2531_RS09330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
pBML2531_RS09335	COG1047	Peptidyl-prolyl cis-trans
pBML2531_RS09340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
pBML2531_RS09345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
pBML2531_RS09350	COG0505	Belongs to the CarA family
pBML2531_RS09360	COG0789	Transcriptional regulator
pBML2531_RS09370	COG0626	cystathionine gamma-synthase activity
pBML2531_RS09380	COG0848	biopolymer transport protein
pBML2531_RS09385	COG2391	methyltransferase activity
pBML2531_RS09390	COG0425	Belongs to the sulfur carrier protein TusA family
pBML2531_RS09400	COG2974	May be involved in recombination
pBML2531_RS09405	COG1940	carbohydrate kinase activity
pBML2531_RS09410	COG0737	Belongs to the 5'-nucleotidase family
pBML2531_RS09440	COG0419	ATPase involved in DNA repair
pBML2531_RS09445	COG0420	3'-5' exonuclease activity
pBML2531_RS09450	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS09455	COG5002	protein histidine kinase activity
pBML2531_RS09480	COG0450	alkyl hydroperoxide reductase
pBML2531_RS09485	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
pBML2531_RS09490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
pBML2531_RS09500	COG1862	Preprotein translocase
pBML2531_RS09505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
pBML2531_RS09510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
pBML2531_RS09515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
pBML2531_RS09520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
pBML2531_RS09520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
pBML2531_RS09525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
pBML2531_RS09530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
pBML2531_RS09535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
pBML2531_RS09540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
pBML2531_RS09545	COG2271	Major facilitator Superfamily
pBML2531_RS09575	COG1960	acyl-CoA dehydrogenase activity
pBML2531_RS09580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
pBML2531_RS09585	COG0318	PFAM AMP-dependent synthetase and ligase
pBML2531_RS09590	COG1024	Enoyl-CoA hydratase
pBML2531_RS09605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
pBML2531_RS09610	COG0142	geranyltranstransferase activity
pBML2531_RS09620	COG0301	tRNA thio-modification
pBML2531_RS09620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
pBML2531_RS09630	COG0693	protein deglycase activity
pBML2531_RS09635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
pBML2531_RS09640	COG1666	GTP binding
pBML2531_RS09645	COG2814	Major facilitator Superfamily
pBML2531_RS09650	COG0109	protoheme IX farnesyltransferase activity
pBML2531_RS09655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
pBML2531_RS09660	COG1845	cytochrome c oxidase, subunit III
pBML2531_RS09670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
pBML2531_RS09680	COG2223	nitrite transmembrane transporter activity
pBML2531_RS09685	COG3056	Lipoprotein
pBML2531_RS09690	COG0271	Belongs to the BolA IbaG family
pBML2531_RS09695	COG0544	peptidyl-prolyl cis-trans isomerase activity
pBML2531_RS09700	COG0740	serine-type endopeptidase activity
pBML2531_RS09705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
pBML2531_RS09710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
pBML2531_RS09715	COG0776	regulation of translation
pBML2531_RS09720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
pBML2531_RS09725	COG1555	photosystem II stabilization
pBML2531_RS09730	COG0824	Thioesterase
pBML2531_RS09740	COG1522	sequence-specific DNA binding
pBML2531_RS09745	COG1132	(ABC) transporter
pBML2531_RS09750	COG1132	(ABC) transporter
pBML2531_RS09755	COG0347	Belongs to the P(II) protein family
pBML2531_RS09760	COG0004	ammonium transporteR
pBML2531_RS09765	COG1946	Acyl-CoA thioesterase
pBML2531_RS09770	COG3126	Type III secretion system lipoprotein chaperone (YscW)
pBML2531_RS09790	COG0741	lytic transglycosylase activity
pBML2531_RS09790	COG1388	LysM domain
pBML2531_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
pBML2531_RS09800	COG2226	methyltransferase
pBML2531_RS09805	COG0328	RNA-DNA hybrid ribonuclease activity
pBML2531_RS09820	COG1396	sequence-specific DNA binding
pBML2531_RS09845	COG3188	usher protein
pBML2531_RS09865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
pBML2531_RS09870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
pBML2531_RS09875	COG0126	phosphoglycerate kinase activity
pBML2531_RS09890	COG0786	glutamate:sodium symporter activity
pBML2531_RS09895	COG0010	Belongs to the arginase family
pBML2531_RS09905	COG0583	DNA-binding transcription factor activity
pBML2531_RS09915	COG0590	tRNA wobble adenosine to inosine editing
pBML2531_RS09940	COG1704	LemA family
pBML2531_RS10005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
pBML2531_RS10010	COG2368	4-hydroxyphenylacetate
pBML2531_RS10030	COG3971	2-oxopent-4-enoate hydratase activity
pBML2531_RS10040	COG2814	Major facilitator Superfamily
pBML2531_RS10050	COG3384	dioxygenase
pBML2531_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS10065	COG0179	Fumarylacetoacetate (FAA) hydrolase
pBML2531_RS10070	COG1846	Transcriptional regulator
pBML2531_RS10075	COG2831	hemolysin activation secretion protein
pBML2531_RS10080	COG3210	domain, Protein
pBML2531_RS10130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
pBML2531_RS10135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
pBML2531_RS10155	COG2194	sulfuric ester hydrolase activity
pBML2531_RS10160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
pBML2531_RS10170	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
pBML2531_RS10180	COG3118	belongs to the thioredoxin family
pBML2531_RS10190	COG1609	Transcriptional regulator
pBML2531_RS10195	COG1172	Belongs to the binding-protein-dependent transport system permease family
pBML2531_RS10200	COG1129	ABC transporter
pBML2531_RS10205	COG1879	ABC-type sugar transport system periplasmic component
pBML2531_RS10210	COG1063	alcohol dehydrogenase
pBML2531_RS10215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
pBML2531_RS10225	COG0583	DNA-binding transcription factor activity
pBML2531_RS10230	COG1285	pathogenesis
pBML2531_RS10235	COG2211	Major facilitator Superfamily
pBML2531_RS10255	COG0305	Participates in initiation and elongation during chromosome replication
pBML2531_RS10290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
pBML2531_RS10450	COG5290	Psort location Cytoplasmic, score
pBML2531_RS10455	COG2003	Belongs to the UPF0758 family
pBML2531_RS10555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
pBML2531_RS10565	COG0741	lytic transglycosylase activity
pBML2531_RS10570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
pBML2531_RS10575	COG1194	a g-specific adenine glycosylase
pBML2531_RS10585	COG3171	Protein conserved in bacteria
pBML2531_RS10590	COG2066	Belongs to the glutaminase family
pBML2531_RS10600	COG4607	ABC-type enterochelin transport system periplasmic component
pBML2531_RS10605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
pBML2531_RS10610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
pBML2531_RS10615	COG0762	integral membrane protein
pBML2531_RS10620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
pBML2531_RS10625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
pBML2531_RS10630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
pBML2531_RS10635	COG1678	Uncharacterized ACR, COG1678
pBML2531_RS10640	COG0189	ligase activity
pBML2531_RS10645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
pBML2531_RS10665	COG0583	DNA-binding transcription factor activity
pBML2531_RS10670	COG0583	DNA-binding transcription factor activity
pBML2531_RS10695	COG1960	acyl-CoA dehydrogenase activity
pBML2531_RS10705	COG0121	glutamine amidotransferase
pBML2531_RS10710	COG3034	peptidoglycan biosynthetic process
pBML2531_RS10715	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
pBML2531_RS10720	COG1805	sodium ion transport
pBML2531_RS10725	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
pBML2531_RS10730	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
pBML2531_RS10735	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
pBML2531_RS10740	COG2871	sodium ion transport
pBML2531_RS10745	COG1477	protein flavinylation
pBML2531_RS10750	COG2991	Protein conserved in bacteria
pBML2531_RS10765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
pBML2531_RS10770	COG2195	Cleaves the N-terminal amino acid of tripeptides
pBML2531_RS10775	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
pBML2531_RS10795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
pBML2531_RS10800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
pBML2531_RS10805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
pBML2531_RS10810	COG0318	PFAM AMP-dependent synthetase and ligase
pBML2531_RS10810	COG0204	Acyl-transferase
pBML2531_RS10815	COG2814	Major facilitator Superfamily
pBML2531_RS10820	COG1546	Belongs to the CinA family
pBML2531_RS10825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
pBML2531_RS10830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
pBML2531_RS10835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
pBML2531_RS10860	COG2918	glutathione biosynthetic process
pBML2531_RS10865	COG1854	S-ribosylhomocysteine lyase activity
pBML2531_RS10870	COG4536	flavin adenine dinucleotide binding
pBML2531_RS10875	COG4137	Cytochrome C assembly protein
pBML2531_RS10880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
pBML2531_RS10885	COG0228	four-way junction DNA binding
pBML2531_RS10895	COG0336	Belongs to the RNA methyltransferase TrmD family
pBML2531_RS10900	COG0335	large ribosomal subunit rRNA binding
pBML2531_RS10905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
pBML2531_RS10910	COG0287	Prephenate dehydrogenase
pBML2531_RS10910	COG1605	Chorismate mutase
pBML2531_RS10915	COG0840	transmembrane signaling receptor activity
pBML2531_RS10920	COG0077	Prephenate dehydratase
pBML2531_RS10920	COG1605	Chorismate mutase
pBML2531_RS10925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
pBML2531_RS10930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
pBML2531_RS10935	COG0564	pseudouridine synthase activity
pBML2531_RS10945	COG0542	response to heat
pBML2531_RS10975	COG3021	interspecies interaction between organisms
pBML2531_RS10980	COG3738	Protein conserved in bacteria
pBML2531_RS11005	COG0602	queuosine metabolic process
pBML2531_RS11010	COG3477	response to acidic pH
pBML2531_RS11015	COG0720	synthase
pBML2531_RS11020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
pBML2531_RS11025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
pBML2531_RS11035	COG1648	precorrin-2 dehydrogenase activity
pBML2531_RS11035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
pBML2531_RS11040	COG0175	sulfate reduction
pBML2531_RS11045	COG2895	sulfate adenylyltransferase (ATP) activity
pBML2531_RS11050	COG0529	Catalyzes the synthesis of activated sulfate
pBML2531_RS11055	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
pBML2531_RS11060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
pBML2531_RS11065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
pBML2531_RS11070	COG0585	pseudouridine synthase activity
pBML2531_RS11075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
pBML2531_RS11080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
pBML2531_RS11085	COG4942	peptidase
pBML2531_RS11085	COG1388	LysM domain
pBML2531_RS11100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
pBML2531_RS11105	COG2010	Cytochrome c
pBML2531_RS11105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
pBML2531_RS11110	COG2010	Cytochrome c
pBML2531_RS11110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
pBML2531_RS11115	COG2080	2 iron, 2 sulfur cluster binding
pBML2531_RS11120	COG2010	Cytochrome c
pBML2531_RS11120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
pBML2531_RS11135	COG2010	Cytochrome c
pBML2531_RS11135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
pBML2531_RS11160	COG3961	Belongs to the TPP enzyme family
pBML2531_RS11165	COG0251	oxidation-reduction process
pBML2531_RS11175	COG0583	DNA-binding transcription factor activity
pBML2531_RS11180	COG0786	glutamate:sodium symporter activity
pBML2531_RS11195	COG2252	PERMEase
pBML2531_RS11205	COG0583	DNA-binding transcription factor activity
pBML2531_RS11235	COG4633	Protein conserved in bacteria
pBML2531_RS11250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
pBML2531_RS11260	COG4566	intracellular signal transduction
pBML2531_RS11275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS11280	COG2962	Rard protein
pBML2531_RS11295	COG1966	Carbon starvation protein
pBML2531_RS11300	COG2879	small protein
pBML2531_RS11305	COG0523	cobalamin synthesis protein
pBML2531_RS11315	COG0534	Mate efflux family protein
pBML2531_RS11320	COG0673	inositol 2-dehydrogenase activity
pBML2531_RS11330	COG5564	TIM-barrel signal transduction protein
pBML2531_RS11335	COG5441	Belongs to the UPF0261 family
pBML2531_RS11355	COG2132	Multicopper oxidase
pBML2531_RS11385	COG3121	Chaperone
pBML2531_RS11395	COG0842	Transport permease protein
pBML2531_RS11400	COG1131	(ABC) transporter
pBML2531_RS11405	COG0288	reversible hydration of carbon dioxide
pBML2531_RS11410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
pBML2531_RS11415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
pBML2531_RS11420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
pBML2531_RS11425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
pBML2531_RS11445	COG1489	DNA binding
pBML2531_RS11450	COG1643	Atp-dependent helicase
pBML2531_RS11455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
pBML2531_RS11460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
pBML2531_RS11475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
pBML2531_RS11485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
pBML2531_RS11490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
pBML2531_RS11495	COG3956	TIGRFAM MazG family protein
pBML2531_RS11500	COG0504	CTP synthase activity
pBML2531_RS11505	COG0148	phosphopyruvate hydratase activity
pBML2531_RS11515	COG0471	metal ion transport
pBML2531_RS11520	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
pBML2531_RS11520	COG3064	Membrane
pBML2531_RS11520	COG3210	domain, Protein
pBML2531_RS11530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
pBML2531_RS11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
pBML2531_RS11540	COG1309	transcriptional regulator
pBML2531_RS11545	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
pBML2531_RS11550	COG3264	Mechanosensitive ion channel
pBML2531_RS11550	COG1196	nuclear chromosome segregation
pBML2531_RS11565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
pBML2531_RS11570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
pBML2531_RS11575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
pBML2531_RS11580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
pBML2531_RS11585	COG0326	Molecular chaperone. Has ATPase activity
pBML2531_RS11590	COG0563	adenylate kinase activity
pBML2531_RS11600	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
pBML2531_RS11605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS11610	COG3192	ethanolamine utilization protein
pBML2531_RS11615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
pBML2531_RS11630	COG1349	DNA-binding transcription factor activity
pBML2531_RS11640	COG4651	solute:proton antiporter activity
pBML2531_RS11640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
pBML2531_RS11645	COG2223	nitrite transmembrane transporter activity
pBML2531_RS11650	COG0737	Belongs to the 5'-nucleotidase family
pBML2531_RS11660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
pBML2531_RS11665	COG3735	TraB family
pBML2531_RS11670	COG3247	response to pH
pBML2531_RS11675	COG2217	Heavy metal translocating P-type atpase
pBML2531_RS11685	COG1585	Membrane protein implicated in regulation of membrane protease activity
pBML2531_RS11695	COG3118	belongs to the thioredoxin family
pBML2531_RS11700	COG0300	oxidoreductase activity
pBML2531_RS11705	COG2755	lipolytic protein G-D-S-L family
pBML2531_RS11710	COG4181	ATPase activity
pBML2531_RS11715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
pBML2531_RS11730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
pBML2531_RS11735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
pBML2531_RS11740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
pBML2531_RS11745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
pBML2531_RS11750	COG0215	cysteine-tRNA ligase activity
pBML2531_RS11755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
pBML2531_RS11755	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
pBML2531_RS11755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
pBML2531_RS11760	COG1105	Belongs to the carbohydrate kinase PfkB family
pBML2531_RS11765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS11765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS11770	COG2501	S4 domain
pBML2531_RS11775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
pBML2531_RS11785	COG0582	viral genome integration into host DNA
pBML2531_RS11840	COG0640	Transcriptional regulator
pBML2531_RS11845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
pBML2531_RS11860	COG2197	response regulator
pBML2531_RS11880	COG3539	Fimbrial protein
pBML2531_RS11915	COG1473	amidohydrolase
pBML2531_RS11975	COG3005	denitrification pathway
pBML2531_RS11980	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS11985	COG1879	ABC-type sugar transport system periplasmic component
pBML2531_RS11990	COG0784	Response regulator, receiver
pBML2531_RS11990	COG2198	Histidine kinase
pBML2531_RS11990	COG2205	protein histidine kinase activity
pBML2531_RS11995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
pBML2531_RS12000	COG0402	S-adenosylhomocysteine deaminase activity
pBML2531_RS12005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
pBML2531_RS12010	COG0583	DNA-binding transcription factor activity
pBML2531_RS12020	COG0513	Belongs to the DEAD box helicase family
pBML2531_RS12030	COG1288	antiporter activity
pBML2531_RS12040	COG0626	cystathionine gamma-synthase activity
pBML2531_RS12050	COG0626	cystathionine gamma-synthase activity
pBML2531_RS12055	COG3381	protein complex oligomerization
pBML2531_RS12060	COG3302	dmso reductase anchor subunit
pBML2531_RS12065	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS12070	COG0243	molybdopterin cofactor binding
pBML2531_RS12075	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
pBML2531_RS12085	COG0583	DNA-binding transcription factor activity
pBML2531_RS12095	COG0443	Heat shock 70 kDa protein
pBML2531_RS12105	COG4235	cytochrome complex assembly
pBML2531_RS12110	COG1138	Cytochrome C-type biogenesis protein
pBML2531_RS12115	COG3301	Polysulphide reductase, NrfD
pBML2531_RS12120	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS12125	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
pBML2531_RS12135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
pBML2531_RS12135	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
pBML2531_RS12140	COG3062	negative regulation of establishment of protein localization
pBML2531_RS12150	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS12155	COG0348	domain, Protein
pBML2531_RS12160	COG3043	anaerobic respiration
pBML2531_RS12165	COG3005	denitrification pathway
pBML2531_RS12170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
pBML2531_RS12175	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
pBML2531_RS12185	COG1138	Cytochrome C-type biogenesis protein
pBML2531_RS12190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
pBML2531_RS12195	COG4235	cytochrome complex assembly
pBML2531_RS12195	COG3088	subunit of a heme lyase
pBML2531_RS12215	COG3708	Transcriptional regulator
pBML2531_RS12215	COG2207	Transcriptional regulator
pBML2531_RS12245	COG0673	inositol 2-dehydrogenase activity
pBML2531_RS12250	COG2814	Major facilitator Superfamily
pBML2531_RS12265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS12275	COG3718	enzyme involved in inositol metabolism
pBML2531_RS12300	COG3038	cytochrome b561
pBML2531_RS12305	COG2353	YceI-like domain
pBML2531_RS12330	COG1151	hydroxylamine reductase activity
pBML2531_RS12335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
pBML2531_RS12345	COG2239	Acts as a magnesium transporter
pBML2531_RS12350	COG3091	SprT-like family
pBML2531_RS12355	COG0640	Transcriptional regulator
pBML2531_RS12370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
pBML2531_RS12375	COG1166	arginine decarboxylase activity
pBML2531_RS12380	COG0010	Belongs to the arginase family
pBML2531_RS12400	COG0861	Integral membrane protein TerC family
pBML2531_RS12405	COG3066	DNA modification
pBML2531_RS12410	COG4533	DNA binding
pBML2531_RS12420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
pBML2531_RS12430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
pBML2531_RS12445	COG1022	Amp-dependent synthetase and ligase
pBML2531_RS12450	COG0028	Belongs to the TPP enzyme family
pBML2531_RS12465	COG2001	Belongs to the MraZ family
pBML2531_RS12470	COG0275	rRNA processing
pBML2531_RS12475	COG3116	cell division
pBML2531_RS12480	COG0768	penicillin binding
pBML2531_RS12485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
pBML2531_RS12490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
pBML2531_RS12495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
pBML2531_RS12500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
pBML2531_RS12505	COG0772	Belongs to the SEDS family
pBML2531_RS12510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
pBML2531_RS12515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
pBML2531_RS12520	COG1181	Belongs to the D-alanine--D-alanine ligase family
pBML2531_RS12525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
pBML2531_RS12530	COG0849	cell division
pBML2531_RS12535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
pBML2531_RS12540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
pBML2531_RS12555	COG0653	protein targeting
pBML2531_RS12560	COG0494	nUDIX hydrolase
pBML2531_RS12570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
pBML2531_RS12575	COG0237	dephospho-CoA kinase activity
pBML2531_RS12585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
pBML2531_RS12590	COG4969	Belongs to the N-Me-Phe pilin family
pBML2531_RS12595	COG3023	N-Acetylmuramoyl-L-alanine amidase
pBML2531_RS12605	COG2186	Transcriptional regulator
pBML2531_RS12610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
pBML2531_RS12615	COG0508	dehydrogenase complex catalyzes the overall conversion of
pBML2531_RS12620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
pBML2531_RS12710	COG3112	Uncharacterised protein family (UPF0231)
pBML2531_RS12715	COG0668	transmembrane transport
pBML2531_RS12720	COG1279	arginine transmembrane transporter activity
pBML2531_RS12730	COG0583	DNA-binding transcription factor activity
pBML2531_RS12735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
pBML2531_RS12740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
pBML2531_RS12745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
pBML2531_RS12755	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
pBML2531_RS12760	COG3079	Belongs to the UPF0149 family
pBML2531_RS12765	COG0006	proline dipeptidase activity
pBML2531_RS12770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
pBML2531_RS12775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
pBML2531_RS12780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
pBML2531_RS12785	COG0509	glycine decarboxylation via glycine cleavage system
pBML2531_RS12790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
pBML2531_RS12790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
pBML2531_RS12805	COG0354	folic acid binding
pBML2531_RS12810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
pBML2531_RS12820	COG0716	FMN binding
pBML2531_RS12830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
pBML2531_RS12835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
pBML2531_RS12845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
pBML2531_RS12880	COG0589	response to stress
pBML2531_RS12890	COG2017	converts alpha-aldose to the beta-anomer
pBML2531_RS12895	COG2079	MmgE PrpD family protein
pBML2531_RS12900	COG0372	Belongs to the citrate synthase family
pBML2531_RS12905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
pBML2531_RS12935	COG3781	membrane
pBML2531_RS12965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
pBML2531_RS12970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
pBML2531_RS12975	COG4558	Periplasmic binding protein
pBML2531_RS12980	COG3720	iron ion transport
pBML2531_RS12990	COG4256	Hemin uptake protein
pBML2531_RS12995	COG0702	epimerase
pBML2531_RS13000	COG2271	Major facilitator Superfamily
pBML2531_RS13015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
pBML2531_RS13020	COG2017	converts alpha-aldose to the beta-anomer
pBML2531_RS13025	COG1609	Transcriptional regulator
pBML2531_RS13035	COG4774	siderophore transport
pBML2531_RS13040	COG1120	ATPase activity
pBML2531_RS13065	COG2211	Major facilitator Superfamily
pBML2531_RS13070	COG0673	inositol 2-dehydrogenase activity
pBML2531_RS13080	COG0673	inositol 2-dehydrogenase activity
pBML2531_RS13115	COG2246	polysaccharide biosynthetic process
pBML2531_RS13200	COG0582	viral genome integration into host DNA
pBML2531_RS13205	COG4974	Belongs to the 'phage' integrase family
pBML2531_RS13270	COG4695	Portal protein
pBML2531_RS13405	COG2867	negative regulation of translational initiation
pBML2531_RS13410	COG2914	Belongs to the UPF0125 (RnfH) family
pBML2531_RS13415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
pBML2531_RS13420	COG0497	DNA recombination
pBML2531_RS13425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
pBML2531_RS13430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
pBML2531_RS13435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
pBML2531_RS13450	COG0513	Belongs to the DEAD box helicase family
pBML2531_RS13455	COG0786	glutamate:sodium symporter activity
pBML2531_RS13470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
pBML2531_RS13475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
pBML2531_RS13495	COG3086	response to oxidative stress
pBML2531_RS13515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
pBML2531_RS13520	COG1381	Involved in DNA repair and RecF pathway recombination
pBML2531_RS13525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
pBML2531_RS13535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
pBML2531_RS13555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
pBML2531_RS13560	COG0047	phosphoribosylformylglycinamidine synthase activity
pBML2531_RS13560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
pBML2531_RS13565	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
pBML2531_RS13570	COG0561	phosphatase activity
pBML2531_RS13605	COG3842	ATPase activity
pBML2531_RS13615	COG1840	ABC-type Fe3 transport system, periplasmic component
pBML2531_RS13620	COG2271	Major facilitator Superfamily
pBML2531_RS13640	COG2205	protein histidine kinase activity
pBML2531_RS13645	COG3170	Tfp pilus assembly protein FimV
pBML2531_RS13650	COG2204	response regulator
pBML2531_RS13655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
pBML2531_RS13655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
pBML2531_RS13660	COG0347	Belongs to the P(II) protein family
pBML2531_RS13665	COG1017	nitric oxide dioxygenase activity
pBML2531_RS13665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
pBML2531_RS13670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
pBML2531_RS13675	COG2814	Major facilitator Superfamily
pBML2531_RS13680	COG3121	Chaperone
pBML2531_RS13695	COG3121	Chaperone
pBML2531_RS13705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
pBML2531_RS13715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
pBML2531_RS13725	COG1802	Transcriptional regulator
pBML2531_RS13730	COG1063	alcohol dehydrogenase
pBML2531_RS13735	COG0483	inositol monophosphate 1-phosphatase activity
pBML2531_RS13740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
pBML2531_RS13745	COG1959	2 iron, 2 sulfur cluster binding
pBML2531_RS13750	COG1104	cysteine desulfurase activity
pBML2531_RS13755	COG0822	iron-sulfur transferase activity
pBML2531_RS13760	COG0316	Belongs to the HesB IscA family
pBML2531_RS13770	COG0443	Heat shock 70 kDa protein
pBML2531_RS13775	COG0633	Ferredoxin
pBML2531_RS13790	COG2975	iron-sulfur cluster assembly
pBML2531_RS13795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
pBML2531_RS13810	COG4953	penicillin-binding protein 1C
pBML2531_RS13815	COG0105	UTP biosynthetic process
pBML2531_RS13820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
pBML2531_RS13835	COG0124	histidyl-tRNA synthetase
pBML2531_RS13840	COG2976	Protein conserved in bacteria
pBML2531_RS13845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
pBML2531_RS13855	COG1187	pseudouridine synthase activity
pBML2531_RS13865	COG0408	coproporphyrinogen oxidase activity
pBML2531_RS13870	COG0456	acetyltransferase
pBML2531_RS13880	COG2837	iron assimilation
pBML2531_RS13895	COG4150	thiosulfate binding
pBML2531_RS13905	COG4208	sulfate ABC transporter
pBML2531_RS13910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
pBML2531_RS13915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
pBML2531_RS13920	COG2190	(PTS) system
pBML2531_RS13925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
pBML2531_RS13930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS13945	COG3115	cell septum assembly
pBML2531_RS13950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
pBML2531_RS13955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
pBML2531_RS13960	COG3530	Putative quorum-sensing-regulated virulence factor
pBML2531_RS13975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
pBML2531_RS14010	COG1396	sequence-specific DNA binding
pBML2531_RS14020	COG2011	ABC-type metal ion transport system permease component
pBML2531_RS14025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
pBML2531_RS14030	COG2072	flavoprotein involved in K transport
pBML2531_RS14055	COG2213	PTS system mannitol-specific
pBML2531_RS14055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS14065	COG3722	fumarate hydratase activity
pBML2531_RS14095	COG2067	long-chain fatty acid transport protein
pBML2531_RS14100	COG3691	Protein conserved in bacteria
pBML2531_RS14105	COG0183	Belongs to the thiolase family
pBML2531_RS14110	COG1024	Enoyl-CoA hydratase
pBML2531_RS14110	COG1250	3-hydroxyacyl-CoA dehydrogenase
pBML2531_RS14115	COG2062	phosphohistidine phosphatase, SixA
pBML2531_RS14120	COG2840	Smr protein MutS2
pBML2531_RS14125	COG1228	amidohydrolase
pBML2531_RS14135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
pBML2531_RS14140	COG2986	histidine ammonia-lyase
pBML2531_RS14155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
pBML2531_RS14160	COG0730	response to heat
pBML2531_RS14165	COG3101	peptidyl-lysine hydroxylation
pBML2531_RS14180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
pBML2531_RS14180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
pBML2531_RS14185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
pBML2531_RS14215	COG0642	Histidine kinase
pBML2531_RS14235	COG0697	spore germination
pBML2531_RS14240	COG2207	Transcriptional regulator
pBML2531_RS14245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
pBML2531_RS14250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
pBML2531_RS14255	COG0101	tRNA pseudouridine synthase activity
pBML2531_RS14260	COG0586	Pfam SNARE associated Golgi protein
pBML2531_RS14265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
pBML2531_RS14270	COG0285	dihydrofolate synthase activity
pBML2531_RS14275	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
pBML2531_RS14280	COG1286	toxin biosynthetic process
pBML2531_RS14285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
pBML2531_RS14290	COG3878	Protein conserved in bacteria
pBML2531_RS14300	COG1090	epimerase
pBML2531_RS14305	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
pBML2531_RS14320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
pBML2531_RS14325	COG0280	phosphate acetyltransferase
pBML2531_RS14325	COG0857	belongs to the CobB CobQ family
pBML2531_RS14330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
pBML2531_RS14335	COG3092	negative regulation of chromosome organization
pBML2531_RS14340	COG3013	Belongs to the UPF0304 family
pBML2531_RS14370	COG3501	Rhs element vgr protein
pBML2531_RS14380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
pBML2531_RS14385	COG0490	domain, Protein
pBML2531_RS14385	COG0471	metal ion transport
pBML2531_RS14400	COG0436	Aminotransferase
pBML2531_RS14405	COG0583	DNA-binding transcription factor activity
pBML2531_RS14410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
pBML2531_RS14420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
pBML2531_RS14420	COG0649	NAD binding
pBML2531_RS14430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
pBML2531_RS14440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
pBML2531_RS14445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
pBML2531_RS14450	COG0839	Belongs to the complex I subunit 6 family
pBML2531_RS14455	COG0713	ATP synthesis coupled electron transport
pBML2531_RS14460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
pBML2531_RS14465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
pBML2531_RS14470	COG1007	ATP synthesis coupled electron transport
pBML2531_RS14485	COG1169	isochorismate synthase
pBML2531_RS14490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
pBML2531_RS14500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
pBML2531_RS14505	COG1441	menaquinone biosynthetic process
pBML2531_RS14525	COG5464	transposase or invertase
pBML2531_RS14530	COG0814	amino acid
pBML2531_RS14535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
pBML2531_RS14540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
pBML2531_RS14545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
pBML2531_RS14550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
pBML2531_RS14555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
pBML2531_RS14565	COG0784	Response regulator, receiver
pBML2531_RS14565	COG2205	protein histidine kinase activity
pBML2531_RS14575	COG2198	Histidine kinase
pBML2531_RS14575	COG0642	Histidine kinase
pBML2531_RS14590	COG1560	Kdo2-lipid A biosynthetic process
pBML2531_RS14595	COG1301	dicarboxylic acid transport
pBML2531_RS14605	COG1914	H( )-stimulated, divalent metal cation uptake system
pBML2531_RS14610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
pBML2531_RS14615	COG4336	lyase activity
pBML2531_RS14625	COG4770	biotin carboxylase activity
pBML2531_RS14640	COG3381	protein complex oligomerization
pBML2531_RS14645	COG3302	dmso reductase anchor subunit
pBML2531_RS14650	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS14655	COG0243	molybdopterin cofactor binding
pBML2531_RS14660	COG0668	transmembrane transport
pBML2531_RS14675	COG1335	isochorismatase
pBML2531_RS14705	COG2226	methyltransferase
pBML2531_RS14720	COG3083	sulfuric ester hydrolase activity
pBML2531_RS14725	COG3082	Protein of unknown function (DUF1414)
pBML2531_RS14730	COG3081	Nucleoid-associated protein
pBML2531_RS14735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
pBML2531_RS14740	COG1061	Type III restriction enzyme res subunit
pBML2531_RS14745	COG1187	pseudouridine synthase activity
pBML2531_RS14750	COG2814	Major facilitator Superfamily
pBML2531_RS14760	COG0791	NLP P60 protein
pBML2531_RS14775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
pBML2531_RS14780	COG0814	amino acid
pBML2531_RS14790	COG1105	Belongs to the carbohydrate kinase PfkB family
pBML2531_RS14795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
pBML2531_RS14800	COG2855	membrane
pBML2531_RS14805	COG0583	DNA-binding transcription factor activity
pBML2531_RS14810	COG0833	amino acid
pBML2531_RS14820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
pBML2531_RS14825	COG1120	ATPase activity
pBML2531_RS14845	COG0277	FAD linked oxidase domain protein
pBML2531_RS14850	COG2925	Exonuclease
pBML2531_RS14855	COG2211	Major facilitator Superfamily
pBML2531_RS14860	COG2926	Belongs to the UPF0265 family
pBML2531_RS14870	COG0243	molybdopterin cofactor binding
pBML2531_RS14875	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS14890	COG1530	ribonuclease E activity
pBML2531_RS14890	COG1530	ribonuclease E activity
pBML2531_RS14895	COG0564	pseudouridine synthase activity
pBML2531_RS14900	COG0424	maF-like protein
pBML2531_RS14905	COG1399	metal-binding, possibly nucleic acid-binding protein
pBML2531_RS14910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
pBML2531_RS14915	COG0416	fatty acid biosynthetic process
pBML2531_RS14920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
pBML2531_RS14925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
pBML2531_RS14935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
pBML2531_RS14940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
pBML2531_RS14945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
pBML2531_RS14950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
pBML2531_RS14955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
pBML2531_RS14960	COG0470	DNA polymerase III
pBML2531_RS14965	COG0084	hydrolase, TatD family'
pBML2531_RS14970	COG0537	adenosine 5'-monophosphoramidase activity
pBML2531_RS14980	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
pBML2531_RS14985	COG0510	thiamine kinase activity
pBML2531_RS14990	COG1472	Belongs to the glycosyl hydrolase 3 family
pBML2531_RS15000	COG0737	Belongs to the 5'-nucleotidase family
pBML2531_RS15005	COG1252	NADH dehydrogenase
pBML2531_RS15015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
pBML2531_RS15020	COG4591	ABC-type transport system involved in lipoprotein release permease component
pBML2531_RS15025	COG1136	(ABC) transporter
pBML2531_RS15030	COG4591	ABC-type transport system involved in lipoprotein release permease component
pBML2531_RS15040	COG2862	Uncharacterized protein family, UPF0114
pBML2531_RS15050	COG0300	oxidoreductase activity
pBML2531_RS15060	COG1280	lysine exporter protein (LysE YggA)
pBML2531_RS15065	COG2850	peptidyl-arginine hydroxylation
pBML2531_RS15075	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS15085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
pBML2531_RS15090	COG2915	High frequency lysogenization protein hflD homolog
pBML2531_RS15095	COG0482	sulfurtransferase activity
pBML2531_RS15105	COG1187	pseudouridine synthase activity
pBML2531_RS15110	COG0538	isocitrate dehydrogenase activity
pBML2531_RS15185	COG1396	sequence-specific DNA binding
pBML2531_RS15190	COG2315	Protein conserved in bacteria
pBML2531_RS15200	COG0384	phenazine biosynthesis protein PhzF
pBML2531_RS15220	COG0840	transmembrane signaling receptor activity
pBML2531_RS15235	COG2226	methyltransferase
pBML2531_RS15250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
pBML2531_RS15285	COG1115	amino acid carrier protein
pBML2531_RS15295	COG0561	phosphatase activity
pBML2531_RS15300	COG2207	Transcriptional regulator
pBML2531_RS15310	COG1113	amino acid transport
pBML2531_RS15320	COG1328	CTP reductase activity
pBML2531_RS15325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
pBML2531_RS15335	COG1597	lipid kinase activity
pBML2531_RS15345	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS15350	COG2205	protein histidine kinase activity
pBML2531_RS15355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
pBML2531_RS15360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
pBML2531_RS15365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
pBML2531_RS15375	COG2239	Acts as a magnesium transporter
pBML2531_RS15385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
pBML2531_RS15390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
pBML2531_RS15395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
pBML2531_RS15400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
pBML2531_RS15405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
pBML2531_RS15410	COG2233	PERMEase
pBML2531_RS15415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
pBML2531_RS15420	COG1393	Belongs to the ArsC family
pBML2531_RS15425	COG4783	chaperone-mediated protein folding
pBML2531_RS15430	COG0628	permease
pBML2531_RS15435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
pBML2531_RS15440	COG2716	regulation of RNA biosynthetic process
pBML2531_RS15450	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
pBML2531_RS15455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
pBML2531_RS15460	COG1122	ATPase activity
pBML2531_RS15465	COG1122	ATPase activity
pBML2531_RS15485	COG2707	UPF0756 membrane protein
pBML2531_RS15490	COG1444	tRNA N-acetyltransferase activity
pBML2531_RS15505	COG2832	Protein of unknown function (DUF454)
pBML2531_RS15510	COG1876	peptidase activity
pBML2531_RS15515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
pBML2531_RS15520	COG1393	Belongs to the ArsC family
pBML2531_RS15525	COG2197	response regulator
pBML2531_RS15530	COG0281	malic enzyme
pBML2531_RS15530	COG0280	phosphate acetyltransferase
pBML2531_RS15545	COG1770	oligopeptidase
pBML2531_RS15550	COG1629	transport
pBML2531_RS15550	COG4206	TonB-dependent receptor
pBML2531_RS15555	COG1570	exodeoxyribonuclease VII activity
pBML2531_RS15565	COG0516	GMP reductase activity
pBML2531_RS15565	COG0517	IMP dehydrogenase activity
pBML2531_RS15570	COG0519	Catalyzes the synthesis of GMP from XMP
pBML2531_RS15570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
pBML2531_RS15575	COG0386	Belongs to the glutathione peroxidase family
pBML2531_RS15585	COG0667	Aldo Keto reductase
pBML2531_RS15590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
pBML2531_RS15600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
pBML2531_RS15610	COG2226	methyltransferase
pBML2531_RS15615	COG1971	Probably functions as a manganese efflux pump
pBML2531_RS15620	COG4811	Protein of unknown function (DUF986)
pBML2531_RS15625	COG3716	PTS system mannose fructose sorbose family IID component
pBML2531_RS15630	COG3715	PTS system
pBML2531_RS15635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
pBML2531_RS15635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
pBML2531_RS15640	COG1760	l-serine dehydratase
pBML2531_RS15645	COG0494	nUDIX hydrolase
pBML2531_RS15650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
pBML2531_RS15655	COG3140	Belongs to the UPF0181 family
pBML2531_RS15670	COG1528	Iron-storage protein
pBML2531_RS15675	COG2372	response to copper ion
pBML2531_RS15680	COG1276	copper resistance
pBML2531_RS15700	COG3008	intermembrane lipid transfer
pBML2531_RS15705	COG2995	paraquat-inducible protein a
pBML2531_RS15710	COG1956	GAF domain-containing protein
pBML2531_RS15715	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
pBML2531_RS15730	COG0501	Belongs to the peptidase M48B family
pBML2531_RS15735	COG1115	amino acid carrier protein
pBML2531_RS15750	COG2814	Major facilitator Superfamily
pBML2531_RS15770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
pBML2531_RS15775	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
pBML2531_RS15780	COG2186	Transcriptional regulator
pBML2531_RS15785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
pBML2531_RS15790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
pBML2531_RS15795	COG3713	MltA-interacting MipA family protein
pBML2531_RS15815	COG3139	Protein of unknown function (DUF1315)
pBML2531_RS15820	COG1335	isochorismatase
pBML2531_RS15825	COG0252	asparaginase activity
pBML2531_RS15830	COG0616	signal peptide processing
pBML2531_RS15835	COG0778	Nitroreductase
pBML2531_RS15840	COG0709	Synthesizes selenophosphate from selenide and ATP
pBML2531_RS15845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
pBML2531_RS15850	COG0708	Exodeoxyribonuclease III
pBML2531_RS15855	COG0583	DNA-binding transcription factor activity
pBML2531_RS15865	COG0788	formyltetrahydrofolate deformylase activity
pBML2531_RS15870	COG3012	SEC-C Motif Domain Protein
pBML2531_RS15875	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS15880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
pBML2531_RS15885	COG2916	Histone family protein nucleoid-structuring protein H-NS
pBML2531_RS15890	COG1435	thymidine kinase activity
pBML2531_RS15895	COG1454	alcohol dehydrogenase
pBML2531_RS15895	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS15900	COG2095	MarC family integral membrane protein
pBML2531_RS15915	COG0601	transmembrane transport
pBML2531_RS15920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
pBML2531_RS15930	COG4608	Belongs to the ABC transporter superfamily
pBML2531_RS15940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
pBML2531_RS15950	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
pBML2531_RS15965	COG2917	probably involved in intracellular septation
pBML2531_RS15980	COG3047	cAMP biosynthetic process
pBML2531_RS15985	COG2831	hemolysin activation secretion protein
pBML2531_RS15990	COG3210	domain, Protein
pBML2531_RS15995	COG0159	tryptophan synthase activity
pBML2531_RS16000	COG0133	tryptophan synthase activity
pBML2531_RS16005	COG0135	phosphoribosylanthranilate isomerase activity
pBML2531_RS16005	COG0134	indole-3-glycerol-phosphate synthase activity
pBML2531_RS16010	COG0512	Glutamine amidotransferase of anthranilate synthase
pBML2531_RS16010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
pBML2531_RS16015	COG0512	Glutamine amidotransferase of anthranilate synthase
pBML2531_RS16015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
pBML2531_RS16030	COG0009	L-threonylcarbamoyladenylate synthase
pBML2531_RS16035	COG1187	pseudouridine synthase activity
pBML2531_RS16040	COG3700	Belongs to the class B bacterial acid phosphatase family
pBML2531_RS16045	COG3210	domain, Protein
pBML2531_RS16050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
pBML2531_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS16060	COG0616	signal peptide processing
pBML2531_RS16070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
pBML2531_RS16080	COG3590	peptidase
pBML2531_RS16085	COG0583	DNA-binding transcription factor activity
pBML2531_RS16100	COG0113	porphobilinogen synthase activity
pBML2531_RS16105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
pBML2531_RS16110	COG0671	phosphoesterase, PA-phosphatase related
pBML2531_RS16115	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
pBML2531_RS16120	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
pBML2531_RS16125	COG0284	orotidine-5'-phosphate decarboxylase activity
pBML2531_RS16130	COG0023	Translation Initiation Factor
pBML2531_RS16140	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
pBML2531_RS16150	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
pBML2531_RS16155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
pBML2531_RS16165	COG4659	FMN binding
pBML2531_RS16175	COG4656	Part of a membrane complex involved in electron transport
pBML2531_RS16185	COG4657	Part of a membrane complex involved in electron transport
pBML2531_RS16195	COG0673	inositol 2-dehydrogenase activity
pBML2531_RS16200	COG0385	Bile acid
pBML2531_RS16205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
pBML2531_RS16210	COG5339	Protein conserved in bacteria
pBML2531_RS16215	COG1482	cell wall glycoprotein biosynthetic process
pBML2531_RS16220	COG0114	fumarate hydratase activity
pBML2531_RS16230	COG3397	chitin binding
pBML2531_RS16235	COG2814	Major facilitator Superfamily
pBML2531_RS16240	COG0583	DNA-binding transcription factor activity
pBML2531_RS16245	COG1940	carbohydrate kinase activity
pBML2531_RS16250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
pBML2531_RS16275	COG0210	DNA helicase
pBML2531_RS16285	COG2801	Transposase and inactivated derivatives
pBML2531_RS16425	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
pBML2531_RS16430	COG1280	lysine exporter protein (LysE YggA)
pBML2531_RS16435	COG1671	Belongs to the UPF0178 family
pBML2531_RS16450	COG1309	transcriptional regulator
pBML2531_RS16470	COG0697	spore germination
pBML2531_RS16475	COG1846	Transcriptional regulator
pBML2531_RS16485	COG3552	Protein containing von Willebrand factor type A (VWA) domain
pBML2531_RS16495	COG0714	Associated with various cellular activities
pBML2531_RS16500	COG3831	ATPase activity
pBML2531_RS16505	COG0251	oxidation-reduction process
pBML2531_RS16540	COG1979	alcohol dehydrogenase
pBML2531_RS16545	COG2814	Major facilitator Superfamily
pBML2531_RS16550	COG2814	Major facilitator Superfamily
pBML2531_RS16555	COG2211	Major facilitator Superfamily
pBML2531_RS16560	COG2169	Transcriptional regulator
pBML2531_RS16560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
pBML2531_RS16580	COG2515	1-aminocyclopropane-1-carboxylate deaminase
pBML2531_RS16590	COG0702	epimerase
pBML2531_RS16620	COG2223	nitrite transmembrane transporter activity
pBML2531_RS16640	COG1181	Belongs to the D-alanine--D-alanine ligase family
pBML2531_RS16675	COG4807	Protein conserved in bacteria
pBML2531_RS16680	COG5642	Protein of unknown function (DUF2384)
pBML2531_RS16685	COG5654	RES domain protein
pBML2531_RS16690	COG0583	DNA-binding transcription factor activity
pBML2531_RS16695	COG0825	malonyl-CoA metabolic process
pBML2531_RS16710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
pBML2531_RS16725	COG0765	amino acid transport
pBML2531_RS16730	COG1126	abc transporter atp-binding protein
pBML2531_RS16755	COG1403	HNH endonuclease
pBML2531_RS16770	COG3634	alkyl hydroperoxide reductase activity
pBML2531_RS16780	COG0842	Transport permease protein
pBML2531_RS16785	COG0842	Transport permease protein
pBML2531_RS16785	COG1129	ABC transporter
pBML2531_RS16790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
pBML2531_RS16815	COG0814	amino acid
pBML2531_RS16825	COG3321	synthase
pBML2531_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS16825	COG0604	alcohol dehydrogenase
pBML2531_RS16830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
pBML2531_RS16835	COG0589	response to stress
pBML2531_RS16840	COG1309	transcriptional regulator
pBML2531_RS16850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
pBML2531_RS16855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
pBML2531_RS16865	COG0531	amino acid
pBML2531_RS16870	COG1643	Atp-dependent helicase
pBML2531_RS16880	COG3784	Protein of unknown function (DUF1318)
pBML2531_RS16890	COG2911	Protein conserved in bacteria
pBML2531_RS16895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
pBML2531_RS16905	COG2999	glutathione oxidoreductase activity
pBML2531_RS16940	COG3042	response to heat
pBML2531_RS16950	COG2983	Belongs to the UPF0260 family
pBML2531_RS16955	COG0179	Fumarylacetoacetate (FAA) hydrolase
pBML2531_RS16960	COG2951	lytic endotransglycosylase activity
pBML2531_RS16965	COG3100	YcgL domain-containing protein
pBML2531_RS16970	COG0850	regulation of cytokinetic process
pBML2531_RS16975	COG2894	cell division
pBML2531_RS16980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
pBML2531_RS17010	COG0318	PFAM AMP-dependent synthetase and ligase
pBML2531_RS17020	COG3065	identical protein binding
pBML2531_RS17030	COG1199	ATP-dependent helicase activity
pBML2531_RS17035	COG0251	oxidation-reduction process
pBML2531_RS17040	COG2076	Multidrug Resistance protein
pBML2531_RS17045	COG2076	Multidrug Resistance protein
pBML2531_RS17055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
pBML2531_RS17060	COG1737	Transcriptional regulator
pBML2531_RS17065	COG0469	pyruvate kinase activity
pBML2531_RS17090	COG0583	DNA-binding transcription factor activity
pBML2531_RS17095	COG1560	Kdo2-lipid A biosynthetic process
pBML2531_RS17100	COG0739	heme binding
pBML2531_RS17105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
pBML2531_RS17110	COG1121	(ABC) transporter
pBML2531_RS17115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
pBML2531_RS17120	COG2255	four-way junction helicase activity
pBML2531_RS17125	COG0632	four-way junction helicase activity
pBML2531_RS17130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
pBML2531_RS17135	COG0217	transcriptional regulatory protein
pBML2531_RS17140	COG0494	nUDIX hydrolase
pBML2531_RS17145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
pBML2531_RS17160	COG3788	relative of glutathione S-transferase, MAPEG superfamily
pBML2531_RS17165	COG2226	methyltransferase
pBML2531_RS17170	COG0500	methyltransferase
pBML2531_RS17175	COG3302	dmso reductase anchor subunit
pBML2531_RS17180	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS17185	COG0243	molybdopterin cofactor binding
pBML2531_RS17190	COG3142	Participates in the control of copper homeostasis
pBML2531_RS17195	COG3102	Protein conserved in bacteria
pBML2531_RS17200	COG0018	arginyl-trna synthetase
pBML2531_RS17220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
pBML2531_RS17225	COG0477	Major facilitator Superfamily
pBML2531_RS17235	COG3381	protein complex oligomerization
pBML2531_RS17240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
pBML2531_RS17250	COG1115	amino acid carrier protein
pBML2531_RS17255	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS17260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
pBML2531_RS17265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
pBML2531_RS17275	COG4977	sequence-specific DNA binding
pBML2531_RS17280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
pBML2531_RS17285	COG2267	carboxylic ester hydrolase activity
pBML2531_RS17290	COG0671	phosphoesterase, PA-phosphatase related
pBML2531_RS17290	COG2453	phosphatase
pBML2531_RS17300	COG0659	secondary active sulfate transmembrane transporter activity
pBML2531_RS17310	COG1242	4 iron, 4 sulfur cluster binding
pBML2531_RS17325	COG2890	protein-(glutamine-N5) methyltransferase activity
pBML2531_RS17330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
pBML2531_RS17335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
pBML2531_RS17340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
pBML2531_RS17345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
pBML2531_RS17350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
pBML2531_RS17360	COG0193	aminoacyl-tRNA hydrolase activity
pBML2531_RS17365	COG0012	GTP binding
pBML2531_RS17385	COG3188	usher protein
pBML2531_RS17410	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
pBML2531_RS17415	COG0583	DNA-binding transcription factor activity
pBML2531_RS17420	COG3961	Belongs to the TPP enzyme family
pBML2531_RS17435	COG1288	antiporter activity
pBML2531_RS17450	COG4772	TonB-dependent receptor
pBML2531_RS17460	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS17465	COG0243	molybdopterin cofactor binding
pBML2531_RS17485	COG1280	lysine exporter protein (LysE YggA)
pBML2531_RS17495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
pBML2531_RS17500	COG1271	oxidase subunit
pBML2531_RS17505	COG1294	oxidase, subunit
pBML2531_RS17520	COG2375	cellular response to nickel ion
pBML2531_RS17525	COG3443	Belongs to the bacterial solute-binding protein 9 family
pBML2531_RS17530	COG1702	phosphate starvation-inducible protein PhoH
pBML2531_RS17535	COG2356	endonuclease I
pBML2531_RS17540	COG3610	response to peptide
pBML2531_RS17545	COG2966	Psort location CytoplasmicMembrane, score
pBML2531_RS17565	COG0589	response to stress
pBML2531_RS17575	COG0589	response to stress
pBML2531_RS17585	COG0673	inositol 2-dehydrogenase activity
pBML2531_RS17590	COG0791	NLP P60 protein
pBML2531_RS17605	COG1794	racemase activity, acting on amino acids and derivatives
pBML2531_RS17630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
pBML2531_RS17635	COG0037	tRNA processing
pBML2531_RS17640	COG0598	Magnesium transport protein CorA
pBML2531_RS17645	COG4166	transmembrane transport
pBML2531_RS17665	COG3768	UPF0283 membrane protein
pBML2531_RS17670	COG3106	COG3106 Predicted ATPase
pBML2531_RS17675	COG1983	PspC domain protein
pBML2531_RS17685	COG1842	Phage shock protein A
pBML2531_RS17690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
pBML2531_RS17700	COG4166	transmembrane transport
pBML2531_RS17710	COG4171	peptide transport system, permease
pBML2531_RS17720	COG4172	Belongs to the ABC transporter superfamily
pBML2531_RS17725	COG3739	integral membrane protein
pBML2531_RS17735	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
pBML2531_RS17740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
pBML2531_RS17745	COG0259	pyridoxamine-phosphate oxidase activity
pBML2531_RS17750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
pBML2531_RS17755	COG3133	Outer membrane lipoprotein
pBML2531_RS17760	COG1846	Transcriptional regulator
pBML2531_RS17765	COG3313	Fe-S protein
pBML2531_RS17770	COG0346	lactoylglutathione lyase activity
pBML2531_RS17775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
pBML2531_RS17780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
pBML2531_RS17790	COG1609	Transcriptional regulator
pBML2531_RS17795	COG0583	DNA-binding transcription factor activity
pBML2531_RS17800	COG2814	Major facilitator Superfamily
pBML2531_RS17815	COG0307	riboflavin synthase, alpha
pBML2531_RS17820	COG0534	Mate efflux family protein
pBML2531_RS17840	COG0469	pyruvate kinase activity
pBML2531_RS17845	COG4238	major outer membrane lipoprotein
pBML2531_RS17850	COG1388	LysM domain
pBML2531_RS17850	COG1376	ErfK ybiS ycfS ynhG family protein
pBML2531_RS17855	COG2166	iron-sulfur cluster assembly
pBML2531_RS17860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
pBML2531_RS17865	COG0719	Fe-S assembly protein
pBML2531_RS17870	COG0396	ATPase activity
pBML2531_RS17875	COG0719	Fe-S assembly protein
pBML2531_RS17880	COG0316	Belongs to the HesB IscA family
pBML2531_RS17885	COG2050	protein possibly involved in aromatic compounds catabolism
pBML2531_RS17890	COG0247	lactate metabolic process
pBML2531_RS17890	COG0277	FAD linked oxidase domain protein
pBML2531_RS17895	COG0628	permease
pBML2531_RS17900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
pBML2531_RS17900	COG0574	Belongs to the PEP-utilizing enzyme family
pBML2531_RS17905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
pBML2531_RS17920	COG3720	iron ion transport
pBML2531_RS17925	COG2207	Transcriptional regulator
pBML2531_RS17935	COG0791	NLP P60 protein
pBML2531_RS17940	COG2076	Multidrug Resistance protein
pBML2531_RS17945	COG2076	Multidrug Resistance protein
pBML2531_RS17950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
pBML2531_RS17955	COG0726	polysaccharide deacetylase
pBML2531_RS17960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
pBML2531_RS17960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
pBML2531_RS17965	COG0463	Glycosyl transferase, family 2
pBML2531_RS17970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
pBML2531_RS17975	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
pBML2531_RS17980	COG4139	cobalamin transport
pBML2531_RS17990	COG0776	regulation of translation
pBML2531_RS17995	COG0072	phenylalanine-tRNA ligase activity
pBML2531_RS17995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
pBML2531_RS18000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
pBML2531_RS18010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
pBML2531_RS18015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
pBML2531_RS18025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
pBML2531_RS18030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
pBML2531_RS18065	COG0803	Belongs to the bacterial solute-binding protein 9 family
pBML2531_RS18070	COG1121	(ABC) transporter
pBML2531_RS18075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
pBML2531_RS18080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
pBML2531_RS18100	COG0542	response to heat
pBML2531_RS18105	COG3001	Fructosamine kinase
pBML2531_RS18115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
pBML2531_RS18120	COG1988	membrane-bound metal-dependent
pBML2531_RS18130	COG0727	PFAM Uncharacterised protein family (UPF0153)
pBML2531_RS18135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
pBML2531_RS18145	COG3422	double-strand break repair
pBML2531_RS18170	COG1473	amidohydrolase
pBML2531_RS18190	COG1070	Carbohydrate kinase
pBML2531_RS18195	COG0246	Mannitol dehydrogenase
pBML2531_RS18210	COG2390	Transcriptional regulator
pBML2531_RS18215	COG1461	Dihydroxyacetone kinase
pBML2531_RS18220	COG2376	Dihydroxyacetone kinase
pBML2531_RS18225	COG2814	Major facilitator Superfamily
pBML2531_RS18230	COG1063	alcohol dehydrogenase
pBML2531_RS18235	COG0698	ribose 5-phosphate isomerase
pBML2531_RS18240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
pBML2531_RS18245	COG1028	Short-chain dehydrogenase reductase Sdr
pBML2531_RS18250	COG4619	ABC transporter
pBML2531_RS18255	COG0390	transport system, permease component
pBML2531_RS18270	COG1069	ribulokinase activity
pBML2531_RS18290	COG1609	Transcriptional regulator
pBML2531_RS18305	COG3037	sugar-specific permease SgaT UlaA
pBML2531_RS18315	COG1683	Conserved Protein
pBML2531_RS18350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
pBML2531_RS18355	COG1349	DNA-binding transcription factor activity
pBML2531_RS18360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
pBML2531_RS18400	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
pBML2531_RS18440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
pBML2531_RS18445	COG0322	excinuclease ABC activity
pBML2531_RS18450	COG2197	response regulator
pBML2531_RS18455	COG2195	Cleaves the N-terminal amino acid of tripeptides
pBML2531_RS18460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
pBML2531_RS18495	COG1494	fructose-1,6-bisphosphatase
pBML2531_RS18510	COG4565	transcriptional regulatory protein
pBML2531_RS18515	COG3290	protein histidine kinase activity
pBML2531_RS18520	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
pBML2531_RS18530	COG2301	Belongs to the HpcH HpaI aldolase family
pBML2531_RS18535	COG3051	citrate lyase alpha subunit
pBML2531_RS18550	COG0471	metal ion transport
pBML2531_RS18555	COG2828	Protein conserved in bacteria
pBML2531_RS18570	COG2720	vancomycin resistance protein
pBML2531_RS18575	COG2851	Citrate transporter
pBML2531_RS18580	COG1902	pentaerythritol trinitrate reductase activity
pBML2531_RS18600	COG0471	metal ion transport
pBML2531_RS18610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
pBML2531_RS18615	COG1012	belongs to the aldehyde dehydrogenase family
pBML2531_RS18620	COG1309	transcriptional regulator
pBML2531_RS18625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
pBML2531_RS18640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
pBML2531_RS18645	COG0800	Aldolase
pBML2531_RS18670	COG1191	sigma factor activity
pBML2531_RS18700	COG0242	peptide deformylase activity
pBML2531_RS18720	COG5510	response to toxic substance
pBML2531_RS18730	COG1278	Cold shock
pBML2531_RS18740	COG1677	Flagellar hook-basal body complex protein FliE
pBML2531_RS18745	COG1766	The M ring may be actively involved in energy transduction
pBML2531_RS18755	COG1317	bacterial-type flagellum organization
pBML2531_RS18765	COG2882	bacterial-type flagellum organization
pBML2531_RS18775	COG1580	Controls the rotational direction of flagella during chemotaxis
pBML2531_RS18785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
pBML2531_RS18835	COG1706	bacterial-type flagellum-dependent cell motility
pBML2531_RS18840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
pBML2531_RS18860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
pBML2531_RS18865	COG1558	bacterial-type flagellum-dependent cell motility
pBML2531_RS18870	COG1815	bacterial-type flagellum-dependent cell motility
pBML2531_RS18900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
pBML2531_RS18930	COG0745	RESPONSE REGULATOR receiver
pBML2531_RS18935	COG2201	protein-glutamate methylesterase activity
pBML2531_RS18940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
pBML2531_RS18945	COG0840	transmembrane signaling receptor activity
pBML2531_RS18955	COG0835	chemotaxis
pBML2531_RS18985	COG1598	PFAM Uncharacterised protein family UPF0150
pBML2531_RS19000	COG1113	amino acid transport
pBML2531_RS19010	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
pBML2531_RS19010	COG0506	proline dehydrogenase activity
pBML2531_RS19010	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
pBML2531_RS19030	COG1285	pathogenesis
pBML2531_RS19070	COG0418	dihydroorotase activity
pBML2531_RS19085	COG0071	Belongs to the small heat shock protein (HSP20) family
pBML2531_RS19095	COG3683	transport system, periplasmic component
pBML2531_RS19100	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
pBML2531_RS19130	COG1560	Kdo2-lipid A biosynthetic process
pBML2531_RS19135	COG2814	Major facilitator Superfamily
pBML2531_RS19140	COG3104	oligopeptide transport
pBML2531_RS19160	COG1607	acyl-coa hydrolase
pBML2531_RS19175	COG0519	Catalyzes the synthesis of GMP from XMP
pBML2531_RS19185	COG0456	acetyltransferase
pBML2531_RS19195	COG2864	formate dehydrogenase
pBML2531_RS19200	COG0437	4 iron, 4 sulfur cluster binding
pBML2531_RS19210	COG1742	UPF0060 membrane protein
pBML2531_RS19225	COG2249	NAD(P)H dehydrogenase (quinone) activity
pBML2531_RS19235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
pBML2531_RS19245	COG3585	molybdate ion transport
pBML2531_RS19245	COG2005	Transcriptional regulator
pBML2531_RS19260	COG2388	GCN5-related N-acetyl-transferase
pBML2531_RS19400	COG3501	Rhs element vgr protein
pBML2531_RS19430	COG2920	part of a sulfur-relay system
pBML2531_RS19435	COG1254	Belongs to the acylphosphatase family
pBML2531_RS19440	COG3785	DNA binding
pBML2531_RS19445	COG1832	CoA-binding protein
pBML2531_RS19450	COG1803	Methylglyoxal synthase
pBML2531_RS19455	COG0210	DNA helicase
pBML2531_RS19460	COG1289	transmembrane transporter activity
pBML2531_RS19465	COG3070	regulator of competence-specific genes
pBML2531_RS19470	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
pBML2531_RS19490	COG1067	ATP-dependent peptidase activity
pBML2531_RS19500	COG3130	regulation of translation
pBML2531_RS19505	COG3009	Protein conserved in bacteria
pBML2531_RS19510	COG3008	intermembrane lipid transfer
pBML2531_RS19510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
pBML2531_RS19515	COG2995	paraquat-inducible protein a
pBML2531_RS19520	COG0488	(ABC) transporter
pBML2531_RS19525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
pBML2531_RS19525	COG0116	Belongs to the methyltransferase superfamily
pBML2531_RS19530	COG0633	Ferredoxin
pBML2531_RS19530	COG3217	Mosc domain protein beta barrel domain protein
pBML2531_RS19540	COG0167	dihydroorotate dehydrogenase activity
pBML2531_RS19545	COG0308	aminopeptidase N
pBML2531_RS19550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
pBML2531_RS19555	COG0017	Asparaginyl-tRNA synthetase
pBML2531_RS19560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
pBML2531_RS19565	COG1448	Aminotransferase
pBML2531_RS19570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
pBML2531_RS19575	COG3108	Peptidase M15
pBML2531_RS19580	COG2989	Protein conserved in bacteria
pBML2531_RS19590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
pBML2531_RS19595	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
pBML2531_RS19600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
pBML2531_RS19605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
pBML2531_RS19610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
pBML2531_RS19625	COG1663	tetraacyldisaccharide 4'-kinase activity
pBML2531_RS19630	COG1132	(ABC) transporter
pBML2531_RS19635	COG2333	competence protein COMEC
pBML2531_RS19635	COG0658	competence protein
pBML2531_RS19640	COG0776	regulation of translation
pBML2531_RS19645	COG0539	negative regulation of cytoplasmic translation
pBML2531_RS19650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
pBML2531_RS19655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
pBML2531_RS19660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
pBML2531_RS19665	COG0033	Phosphoglucomutase
pBML2531_RS19670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
pBML2531_RS19675	COG0596	Alpha beta hydrolase
pBML2531_RS19680	COG2274	protein secretion by the type I secretion system
pBML2531_RS19700	COG0716	FMN binding
pBML2531_RS19705	COG0735	belongs to the Fur family
pBML2531_RS19720	COG0252	asparaginase activity
pBML2531_RS19725	COG1944	ATP diphosphatase activity
pBML2531_RS19730	COG2721	sulfolactate sulfo-lyase activity
pBML2531_RS19735	COG2271	Major facilitator Superfamily
pBML2531_RS19740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
pBML2531_RS19745	COG1414	Transcriptional regulator
pBML2531_RS19750	COG2116	formate transmembrane transporter activity
pBML2531_RS19755	COG1882	Formate acetyltransferase
pBML2531_RS19760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
pBML2531_RS19790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
pBML2531_RS19795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
pBML2531_RS19800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)