locus-tag	class	description
G7Y69_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7Y69_RS00010	COG0592	DNA-directed DNA polymerase activity
G7Y69_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G7Y69_RS00020	COG0187	DNA topoisomerase II activity
G7Y69_RS00030	COG2194	sulfuric ester hydrolase activity
G7Y69_RS00040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G7Y69_RS00045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7Y69_RS00050	COG0254	rRNA binding
G7Y69_RS00060	COG1940	carbohydrate kinase activity
G7Y69_RS00120	COG4264	IucA IucC family
G7Y69_RS00125	COG4774	siderophore transport
G7Y69_RS00130	COG0019	diaminopimelate decarboxylase activity
G7Y69_RS00135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G7Y69_RS00140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7Y69_RS00145	COG2814	Major facilitator Superfamily
G7Y69_RS00230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G7Y69_RS00235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G7Y69_RS00240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G7Y69_RS00245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G7Y69_RS00250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G7Y69_RS00255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G7Y69_RS00260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7Y69_RS00275	COG0356	it plays a direct role in the translocation of protons across the membrane
G7Y69_RS00280	COG3312	ion transport
G7Y69_RS00285	COG0357	Ribosomal RNA small subunit methyltransferase G
G7Y69_RS00290	COG0445	tRNA wobble uridine modification
G7Y69_RS00295	COG0716	FMN binding
G7Y69_RS00300	COG1522	sequence-specific DNA binding
G7Y69_RS00305	COG2502	aspartate--ammonia ligase
G7Y69_RS00310	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G7Y69_RS00315	COG0714	Associated with various cellular activities
G7Y69_RS00325	COG1129	ABC transporter
G7Y69_RS00330	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7Y69_RS00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS00345	COG1609	Transcriptional regulator
G7Y69_RS00350	COG0477	Major facilitator Superfamily
G7Y69_RS00355	COG2186	Transcriptional regulator
G7Y69_RS00395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G7Y69_RS00405	COG1072	(Pantothenic acid kinase))
G7Y69_RS00445	COG0051	transcription antitermination factor activity, RNA binding
G7Y69_RS00450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G7Y69_RS00455	COG0088	Forms part of the polypeptide exit tunnel
G7Y69_RS00460	COG0089	rRNA binding
G7Y69_RS00465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G7Y69_RS00475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G7Y69_RS00485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G7Y69_RS00495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G7Y69_RS00500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G7Y69_RS00505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G7Y69_RS00510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G7Y69_RS00515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G7Y69_RS00520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G7Y69_RS00525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G7Y69_RS00530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G7Y69_RS00535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G7Y69_RS00540	COG1841	ribosomal large subunit assembly
G7Y69_RS00545	COG0200	Binds to the 23S rRNA
G7Y69_RS00550	COG0201	protein transport
G7Y69_RS00555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7Y69_RS00560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G7Y69_RS00570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G7Y69_RS00585	COG0789	Transcriptional regulator
G7Y69_RS00590	COG3036	rescue of stalled ribosome
G7Y69_RS00600	COG0569	domain protein
G7Y69_RS00610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7Y69_RS00620	COG0758	DNA mediated transformation
G7Y69_RS00625	COG0551	DNA topoisomerase type I activity
G7Y69_RS00630	COG0009	L-threonylcarbamoyladenylate synthase
G7Y69_RS00635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7Y69_RS00645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G7Y69_RS00675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7Y69_RS00680	COG3162	membrane
G7Y69_RS00685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7Y69_RS00690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G7Y69_RS00695	COG0443	Heat shock 70 kDa protein
G7Y69_RS00705	COG2258	MOSC domain
G7Y69_RS00730	COG1335	isochorismatase
G7Y69_RS00735	COG2353	YceI-like domain
G7Y69_RS00740	COG1304	FMN binding
G7Y69_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS00750	COG0180	Tryptophanyl-tRNA synthetase
G7Y69_RS00755	COG0546	phosphoglycolate phosphatase activity
G7Y69_RS00760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G7Y69_RS00775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G7Y69_RS00780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7Y69_RS00785	COG4796	Type ii and iii secretion system protein
G7Y69_RS00805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G7Y69_RS00810	COG0494	nUDIX hydrolase
G7Y69_RS00820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G7Y69_RS00825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G7Y69_RS00830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G7Y69_RS00835	COG1741	Belongs to the pirin family
G7Y69_RS00840	COG2081	HI0933 family
G7Y69_RS00845	COG0306	phosphate transporter
G7Y69_RS00855	COG0589	response to stress
G7Y69_RS00860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7Y69_RS00865	COG0742	ribosomal rna small subunit methyltransferase
G7Y69_RS00915	COG3122	Protein conserved in bacteria
G7Y69_RS00925	COG1278	Cold shock
G7Y69_RS00930	COG1737	Transcriptional regulator
G7Y69_RS00935	COG1263	PTS System
G7Y69_RS00935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS00940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G7Y69_RS01105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7Y69_RS01110	COG0477	Major facilitator Superfamily
G7Y69_RS01125	COG0402	S-adenosylhomocysteine deaminase activity
G7Y69_RS01130	COG0549	Belongs to the carbamate kinase family
G7Y69_RS01140	COG1304	FMN binding
G7Y69_RS01145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G7Y69_RS01155	COG0666	response to abiotic stimulus
G7Y69_RS01160	COG0583	DNA-binding transcription factor activity
G7Y69_RS01165	COG2819	hydrolase of the alpha beta superfamily
G7Y69_RS01170	COG4771	TonB-dependent receptor
G7Y69_RS01175	COG1566	PFAM secretion protein HlyD family protein
G7Y69_RS01180	COG2814	Major facilitator Superfamily
G7Y69_RS01185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G7Y69_RS01190	COG3327	negative regulation of DNA-templated transcription, initiation
G7Y69_RS01195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
G7Y69_RS01200	COG0183	Belongs to the thiolase family
G7Y69_RS01205	COG2050	protein possibly involved in aromatic compounds catabolism
G7Y69_RS01210	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y69_RS01215	COG1024	Enoyl-CoA hydratase
G7Y69_RS01220	COG1024	Enoyl-CoA hydratase
G7Y69_RS01225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7Y69_RS01230	COG2151	metal-sulfur cluster biosynthetic enzyme
G7Y69_RS01235	COG3396	Phenylacetate-CoA oxygenase
G7Y69_RS01240	COG3460	Phenylacetate-CoA oxygenase
G7Y69_RS01245	COG3396	Phenylacetate-CoA oxygenase
G7Y69_RS01250	COG2030	dehydratase
G7Y69_RS01250	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS01255	COG2226	methyltransferase
G7Y69_RS01270	COG0477	Major facilitator Superfamily
G7Y69_RS01275	COG0028	Belongs to the TPP enzyme family
G7Y69_RS01280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G7Y69_RS01290	COG3189	MarR family transcriptional regulator
G7Y69_RS01305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G7Y69_RS01310	COG1349	DNA-binding transcription factor activity
G7Y69_RS01315	COG0705	Rhomboid family
G7Y69_RS01320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7Y69_RS01325	COG0316	Belongs to the HesB IscA family
G7Y69_RS01325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G7Y69_RS01335	COG2267	carboxylic ester hydrolase activity
G7Y69_RS01350	COG1918	ferrous iron import across plasma membrane
G7Y69_RS01355	COG2183	response to ionizing radiation
G7Y69_RS01360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7Y69_RS01370	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS01375	COG2205	protein histidine kinase activity
G7Y69_RS01380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G7Y69_RS01385	COG0573	inorganic phosphate transmembrane transporter activity
G7Y69_RS01390	COG0581	inorganic phosphate transmembrane transporter activity
G7Y69_RS01400	COG0704	Plays a role in the regulation of phosphate uptake
G7Y69_RS01405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7Y69_RS01415	COG0765	amino acid transport
G7Y69_RS01420	COG2252	PERMEase
G7Y69_RS01430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7Y69_RS01470	COG3539	Fimbrial protein
G7Y69_RS01475	COG3539	Fimbrial protein
G7Y69_RS01510	COG1695	Transcriptional regulator
G7Y69_RS01525	COG1011	Hydrolase
G7Y69_RS01535	COG0456	acetyltransferase
G7Y69_RS01540	COG2982	Protein involved in outer membrane biogenesis
G7Y69_RS01545	COG2233	PERMEase
G7Y69_RS01550	COG0786	glutamate:sodium symporter activity
G7Y69_RS01555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G7Y69_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7Y69_RS01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7Y69_RS01570	COG1758	RNA polymerase activity
G7Y69_RS01580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7Y69_RS01585	COG2860	membrane
G7Y69_RS01590	COG0823	Involved in the tonB-independent uptake of proteins
G7Y69_RS01595	COG5645	(Lipo)protein
G7Y69_RS01605	COG3977	Valine--pyruvate aminotransferase
G7Y69_RS01610	COG2818	Glycosylase
G7Y69_RS01620	COG0751	glycine-tRNA ligase activity
G7Y69_RS01630	COG2831	hemolysin activation secretion protein
G7Y69_RS01635	COG0747	negative chemotaxis
G7Y69_RS01640	COG0601	transmembrane transport
G7Y69_RS01645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7Y69_RS01650	COG0444	Belongs to the ABC transporter superfamily
G7Y69_RS01655	COG4608	Belongs to the ABC transporter superfamily
G7Y69_RS01665	COG0612	Peptidase, M16
G7Y69_RS01670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G7Y69_RS01680	COG1295	ribonuclease BN
G7Y69_RS01690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G7Y69_RS01695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7Y69_RS01705	COG2378	regulation of single-species biofilm formation
G7Y69_RS01715	COG2723	6-phospho-beta-galactosidase activity
G7Y69_RS01730	COG1763	Mo-molybdopterin cofactor biosynthetic process
G7Y69_RS01735	COG0746	molybdenum cofactor guanylyltransferase activity
G7Y69_RS01740	COG3084	Protein conserved in bacteria
G7Y69_RS01745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G7Y69_RS01750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7Y69_RS01755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G7Y69_RS01755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G7Y69_RS01760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G7Y69_RS01785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7Y69_RS01790	COG1765	OsmC-like protein
G7Y69_RS01795	COG3954	Phosphoribulokinase
G7Y69_RS01805	COG0429	hydrolase of the alpha beta-hydrolase fold
G7Y69_RS01825	COG1263	PTS System
G7Y69_RS01825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS01830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
G7Y69_RS01840	COG1982	Orn Lys Arg decarboxylase major
G7Y69_RS01845	COG0488	(ABC) transporter
G7Y69_RS01850	COG2249	NAD(P)H dehydrogenase (quinone) activity
G7Y69_RS01860	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G7Y69_RS01865	COG1047	Peptidyl-prolyl cis-trans
G7Y69_RS01870	COG2900	Belongs to the SlyX family
G7Y69_RS01875	COG0545	Peptidyl-prolyl cis-trans isomerase
G7Y69_RS01880	COG2964	Protein conserved in bacteria
G7Y69_RS01885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G7Y69_RS01900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G7Y69_RS01905	COG0049	tRNA binding
G7Y69_RS01910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7Y69_RS01925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G7Y69_RS01930	COG0250	Participates in transcription elongation, termination and antitermination
G7Y69_RS01935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G7Y69_RS01945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G7Y69_RS01950	COG0222	ribosome binding
G7Y69_RS01955	COG0085	RNA polymerase activity
G7Y69_RS01960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G7Y69_RS01970	COG3069	C4-dicarboxylate transmembrane transporter activity
G7Y69_RS01975	COG2195	Cleaves the N-terminal amino acid of tripeptides
G7Y69_RS01980	COG3119	arylsulfatase activity
G7Y69_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS02005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G7Y69_RS02010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS02010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS02015	COG3716	PTS system mannose fructose sorbose family IID component
G7Y69_RS02020	COG3715	PTS system
G7Y69_RS02025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS02030	COG2222	sugar isomerase
G7Y69_RS02040	COG1349	DNA-binding transcription factor activity
G7Y69_RS02045	COG0641	radical SAM
G7Y69_RS02050	COG3119	arylsulfatase activity
G7Y69_RS02070	COG2233	PERMEase
G7Y69_RS02085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7Y69_RS02105	COG2022	thiamine diphosphate biosynthetic process
G7Y69_RS02110	COG2104	thiamine diphosphate biosynthetic process
G7Y69_RS02115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G7Y69_RS02125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G7Y69_RS02135	COG3842	ATPase activity
G7Y69_RS02140	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G7Y69_RS02160	COG2816	NAD+ diphosphatase activity
G7Y69_RS02165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G7Y69_RS02170	COG1515	deoxyribonuclease V activity
G7Y69_RS02175	COG3068	Protein conserved in bacteria
G7Y69_RS02190	COG0151	Belongs to the GarS family
G7Y69_RS02195	COG0138	bifunctional purine biosynthesis protein purh
G7Y69_RS02225	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
G7Y69_RS02230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G7Y69_RS02240	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G7Y69_RS02245	COG0800	Aldolase
G7Y69_RS02250	COG0129	dihydroxy-acid dehydratase activity
G7Y69_RS02265	COG3023	N-Acetylmuramoyl-L-alanine amidase
G7Y69_RS02270	COG1414	Transcriptional regulator
G7Y69_RS02275	COG1410	methionine synthase
G7Y69_RS02275	COG0646	methionine synthase
G7Y69_RS02290	COG0527	aspartate kinase activity
G7Y69_RS02295	COG0166	Belongs to the GPI family
G7Y69_RS02300	COG3161	chorismate lyase activity
G7Y69_RS02310	COG2937	Belongs to the GPAT DAPAT family
G7Y69_RS02315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G7Y69_RS02325	COG0735	belongs to the Fur family
G7Y69_RS02335	COG3121	Chaperone
G7Y69_RS02365	COG3121	Chaperone
G7Y69_RS02370	COG1446	asparaginase
G7Y69_RS02390	COG0157	Belongs to the NadC ModD family
G7Y69_RS02395	COG0500	methyltransferase
G7Y69_RS02400	COG1120	ATPase activity
G7Y69_RS02415	COG1609	Transcriptional regulator
G7Y69_RS02420	COG3265	gluconokinase activity
G7Y69_RS02425	COG2610	gluconate transmembrane transporter activity
G7Y69_RS02485	COG2992	FlgJ-related protein
G7Y69_RS02515	COG2137	regulation of response to DNA damage stimulus
G7Y69_RS02525	COG3069	C4-dicarboxylate transmembrane transporter activity
G7Y69_RS02530	COG0814	amino acid
G7Y69_RS02535	COG2873	o-acetylhomoserine
G7Y69_RS02540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G7Y69_RS02550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7Y69_RS02555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7Y69_RS02565	COG0789	Transcriptional regulator
G7Y69_RS02580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7Y69_RS02585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G7Y69_RS02630	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7Y69_RS02650	COG0025	NhaP-type Na H and K H
G7Y69_RS02715	COG0243	molybdopterin cofactor binding
G7Y69_RS02720	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS02730	COG3381	protein complex oligomerization
G7Y69_RS02750	COG3541	Predicted nucleotidyltransferase
G7Y69_RS02755	COG1690	Belongs to the RtcB family
G7Y69_RS02765	COG4650	regulator
G7Y69_RS02770	COG1470	cell adhesion involved in biofilm formation
G7Y69_RS02770	COG1388	LysM domain
G7Y69_RS02775	COG1388	LysM domain
G7Y69_RS02775	COG1470	cell adhesion involved in biofilm formation
G7Y69_RS02785	COG1349	DNA-binding transcription factor activity
G7Y69_RS02790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G7Y69_RS02800	COG0738	Major facilitator superfamily
G7Y69_RS02815	COG0668	transmembrane transport
G7Y69_RS02820	COG1982	Orn Lys Arg decarboxylase major
G7Y69_RS02825	COG1957	nucleoside hydrolase
G7Y69_RS02835	COG0483	inositol monophosphate 1-phosphatase activity
G7Y69_RS02840	COG3196	Protein conserved in bacteria
G7Y69_RS02850	COG1335	isochorismatase
G7Y69_RS02855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7Y69_RS02870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7Y69_RS02880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G7Y69_RS02895	COG2814	Major facilitator Superfamily
G7Y69_RS02905	COG0028	Belongs to the TPP enzyme family
G7Y69_RS02910	COG0440	acetolactate synthase activity
G7Y69_RS02915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7Y69_RS02940	COG2252	PERMEase
G7Y69_RS02945	COG0025	NhaP-type Na H and K H
G7Y69_RS02955	COG0583	DNA-binding transcription factor activity
G7Y69_RS02960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G7Y69_RS02965	COG3753	Protein conserved in bacteria
G7Y69_RS02970	COG2084	Dehydrogenase
G7Y69_RS02975	COG3395	kinase activity
G7Y69_RS02980	COG0235	Class ii aldolase
G7Y69_RS02985	COG3622	Belongs to the hyi family
G7Y69_RS02990	COG1349	DNA-binding transcription factor activity
G7Y69_RS02995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7Y69_RS03000	COG2610	gluconate transmembrane transporter activity
G7Y69_RS03005	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
G7Y69_RS03015	COG0586	Pfam SNARE associated Golgi protein
G7Y69_RS03025	COG2226	methyltransferase
G7Y69_RS03030	COG3165	ubiquinone biosynthetic process from chorismate
G7Y69_RS03045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7Y69_RS03050	COG0805	protein transport
G7Y69_RS03065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G7Y69_RS03075	COG0183	Belongs to the thiolase family
G7Y69_RS03080	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y69_RS03080	COG1024	Enoyl-CoA hydratase
G7Y69_RS03090	COG0006	proline dipeptidase activity
G7Y69_RS03095	COG1739	Uncharacterized protein family UPF0029
G7Y69_RS03100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G7Y69_RS03130	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G7Y69_RS03135	COG2197	response regulator
G7Y69_RS03140	COG3850	Histidine kinase
G7Y69_RS03145	COG2354	Protein conserved in bacteria
G7Y69_RS03150	COG1216	Glycosyl transferase, family 2
G7Y69_RS03165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7Y69_RS03175	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS03185	COG0531	amino acid
G7Y69_RS03200	COG1785	Belongs to the alkaline phosphatase family
G7Y69_RS03225	COG2813	Specifically methylates the guanine in position
G7Y69_RS03240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G7Y69_RS03250	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS03265	COG0583	DNA-binding transcription factor activity
G7Y69_RS03270	COG0473	3-isopropylmalate dehydrogenase activity
G7Y69_RS03275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G7Y69_RS03285	COG4667	esterase of the alpha-beta hydrolase superfamily
G7Y69_RS03290	COG0084	hydrolase, TatD family'
G7Y69_RS03305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G7Y69_RS03310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G7Y69_RS03315	COG0813	purine-nucleoside phosphorylase activity
G7Y69_RS03330	COG1247	-acetyltransferase
G7Y69_RS03340	COG0612	Peptidase, M16
G7Y69_RS03345	COG4178	(ABC) transporter
G7Y69_RS03350	COG4771	TonB-dependent receptor
G7Y69_RS03360	COG1595	DNA-templated transcription, initiation
G7Y69_RS03370	COG3726	membrane protein affecting hemolysin expression
G7Y69_RS03375	COG0560	Phosphoserine phosphatase
G7Y69_RS03380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G7Y69_RS03390	COG0488	(ABC) transporter
G7Y69_RS03405	COG0741	lytic transglycosylase activity
G7Y69_RS03410	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
G7Y69_RS03415	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
G7Y69_RS03420	COG0406	alpha-ribazole phosphatase activity
G7Y69_RS03425	COG2207	Transcriptional regulator
G7Y69_RS03425	COG3708	Transcriptional regulator
G7Y69_RS03430	COG3045	CreA protein
G7Y69_RS03435	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS03450	COG0083	homoserine kinase activity
G7Y69_RS03480	COG5002	protein histidine kinase activity
G7Y69_RS03485	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS03515	COG0667	Aldo Keto reductase
G7Y69_RS03520	COG3022	response to hydroperoxide
G7Y69_RS03525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G7Y69_RS03530	COG0521	Mo-molybdopterin cofactor biosynthetic process
G7Y69_RS03535	COG1584	GPR1 FUN34 yaaH family protein
G7Y69_RS03540	COG0443	Heat shock 70 kDa protein
G7Y69_RS03545	COG0484	heat shock protein binding
G7Y69_RS03550	COG0402	S-adenosylhomocysteine deaminase activity
G7Y69_RS03560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7Y69_RS03565	COG0583	DNA-binding transcription factor activity
G7Y69_RS03570	COG0268	Binds directly to 16S ribosomal RNA
G7Y69_RS03575	COG0196	riboflavin kinase activity
G7Y69_RS03580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G7Y69_RS03585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G7Y69_RS03590	COG1047	Peptidyl-prolyl cis-trans
G7Y69_RS03595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G7Y69_RS03600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G7Y69_RS03605	COG0505	Belongs to the CarA family
G7Y69_RS03615	COG0789	Transcriptional regulator
G7Y69_RS03625	COG0626	cystathionine gamma-synthase activity
G7Y69_RS03635	COG0848	biopolymer transport protein
G7Y69_RS03640	COG2391	methyltransferase activity
G7Y69_RS03645	COG0425	Belongs to the sulfur carrier protein TusA family
G7Y69_RS03655	COG2974	May be involved in recombination
G7Y69_RS03660	COG1940	carbohydrate kinase activity
G7Y69_RS03665	COG0737	Belongs to the 5'-nucleotidase family
G7Y69_RS03695	COG0419	ATPase involved in DNA repair
G7Y69_RS03700	COG0420	3'-5' exonuclease activity
G7Y69_RS03705	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS03710	COG5002	protein histidine kinase activity
G7Y69_RS03735	COG0450	alkyl hydroperoxide reductase
G7Y69_RS03740	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
G7Y69_RS03745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G7Y69_RS03755	COG1862	Preprotein translocase
G7Y69_RS03760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7Y69_RS03765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7Y69_RS03770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7Y69_RS03775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7Y69_RS03775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7Y69_RS03780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G7Y69_RS03785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7Y69_RS03790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G7Y69_RS03795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G7Y69_RS03800	COG2271	Major facilitator Superfamily
G7Y69_RS03830	COG1960	acyl-CoA dehydrogenase activity
G7Y69_RS03835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7Y69_RS03840	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y69_RS03845	COG1024	Enoyl-CoA hydratase
G7Y69_RS03860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G7Y69_RS03865	COG0142	geranyltranstransferase activity
G7Y69_RS03875	COG0301	tRNA thio-modification
G7Y69_RS03875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7Y69_RS03885	COG0693	protein deglycase activity
G7Y69_RS03890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G7Y69_RS03895	COG1666	GTP binding
G7Y69_RS03900	COG2814	Major facilitator Superfamily
G7Y69_RS03905	COG0109	protoheme IX farnesyltransferase activity
G7Y69_RS03910	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G7Y69_RS03915	COG1845	cytochrome c oxidase, subunit III
G7Y69_RS03925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G7Y69_RS03935	COG2223	nitrite transmembrane transporter activity
G7Y69_RS03940	COG3056	Lipoprotein
G7Y69_RS03945	COG0271	Belongs to the BolA IbaG family
G7Y69_RS03950	COG0544	peptidyl-prolyl cis-trans isomerase activity
G7Y69_RS03955	COG0740	serine-type endopeptidase activity
G7Y69_RS03960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G7Y69_RS03965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G7Y69_RS03970	COG0776	regulation of translation
G7Y69_RS03975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7Y69_RS03980	COG1555	photosystem II stabilization
G7Y69_RS03985	COG0824	Thioesterase
G7Y69_RS03995	COG1522	sequence-specific DNA binding
G7Y69_RS04000	COG1132	(ABC) transporter
G7Y69_RS04005	COG1132	(ABC) transporter
G7Y69_RS04010	COG0347	Belongs to the P(II) protein family
G7Y69_RS04015	COG0004	ammonium transporteR
G7Y69_RS04020	COG1946	Acyl-CoA thioesterase
G7Y69_RS04025	COG3126	Type III secretion system lipoprotein chaperone (YscW)
G7Y69_RS04045	COG0741	lytic transglycosylase activity
G7Y69_RS04045	COG1388	LysM domain
G7Y69_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7Y69_RS04055	COG2226	methyltransferase
G7Y69_RS04060	COG0328	RNA-DNA hybrid ribonuclease activity
G7Y69_RS04075	COG1396	sequence-specific DNA binding
G7Y69_RS04100	COG3188	usher protein
G7Y69_RS04120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G7Y69_RS04125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G7Y69_RS04130	COG0126	phosphoglycerate kinase activity
G7Y69_RS04145	COG0786	glutamate:sodium symporter activity
G7Y69_RS04150	COG0010	Belongs to the arginase family
G7Y69_RS04160	COG0583	DNA-binding transcription factor activity
G7Y69_RS04170	COG0590	tRNA wobble adenosine to inosine editing
G7Y69_RS04195	COG1704	LemA family
G7Y69_RS04260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7Y69_RS04265	COG2368	4-hydroxyphenylacetate
G7Y69_RS04285	COG3971	2-oxopent-4-enoate hydratase activity
G7Y69_RS04295	COG2814	Major facilitator Superfamily
G7Y69_RS04305	COG3384	dioxygenase
G7Y69_RS04310	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS04320	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7Y69_RS04325	COG1846	Transcriptional regulator
G7Y69_RS04330	COG2831	hemolysin activation secretion protein
G7Y69_RS04335	COG3210	domain, Protein
G7Y69_RS04385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G7Y69_RS04390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G7Y69_RS04410	COG2194	sulfuric ester hydrolase activity
G7Y69_RS04415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G7Y69_RS04425	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7Y69_RS04435	COG3118	belongs to the thioredoxin family
G7Y69_RS04445	COG1609	Transcriptional regulator
G7Y69_RS04450	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7Y69_RS04455	COG1129	ABC transporter
G7Y69_RS04460	COG1879	ABC-type sugar transport system periplasmic component
G7Y69_RS04465	COG1063	alcohol dehydrogenase
G7Y69_RS04470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G7Y69_RS04480	COG0583	DNA-binding transcription factor activity
G7Y69_RS04485	COG1285	pathogenesis
G7Y69_RS04490	COG2211	Major facilitator Superfamily
G7Y69_RS04510	COG0305	Participates in initiation and elongation during chromosome replication
G7Y69_RS04545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G7Y69_RS04705	COG5290	Psort location Cytoplasmic, score
G7Y69_RS04710	COG2003	Belongs to the UPF0758 family
G7Y69_RS04810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G7Y69_RS04820	COG0741	lytic transglycosylase activity
G7Y69_RS04825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G7Y69_RS04830	COG1194	a g-specific adenine glycosylase
G7Y69_RS04840	COG3171	Protein conserved in bacteria
G7Y69_RS04845	COG2066	Belongs to the glutaminase family
G7Y69_RS04855	COG4607	ABC-type enterochelin transport system periplasmic component
G7Y69_RS04860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7Y69_RS04865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G7Y69_RS04870	COG0762	integral membrane protein
G7Y69_RS04875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G7Y69_RS04880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G7Y69_RS04885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G7Y69_RS04890	COG1678	Uncharacterized ACR, COG1678
G7Y69_RS04895	COG0189	ligase activity
G7Y69_RS04900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G7Y69_RS04920	COG0583	DNA-binding transcription factor activity
G7Y69_RS04925	COG0583	DNA-binding transcription factor activity
G7Y69_RS04950	COG1960	acyl-CoA dehydrogenase activity
G7Y69_RS04960	COG0121	glutamine amidotransferase
G7Y69_RS04965	COG3034	peptidoglycan biosynthetic process
G7Y69_RS04970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G7Y69_RS04975	COG1805	sodium ion transport
G7Y69_RS04980	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G7Y69_RS04985	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G7Y69_RS04990	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G7Y69_RS04995	COG2871	sodium ion transport
G7Y69_RS05000	COG1477	protein flavinylation
G7Y69_RS05005	COG2991	Protein conserved in bacteria
G7Y69_RS05020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G7Y69_RS05025	COG2195	Cleaves the N-terminal amino acid of tripeptides
G7Y69_RS05030	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G7Y69_RS05050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G7Y69_RS05055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G7Y69_RS05060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7Y69_RS05065	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y69_RS05065	COG0204	Acyl-transferase
G7Y69_RS05070	COG2814	Major facilitator Superfamily
G7Y69_RS05075	COG1546	Belongs to the CinA family
G7Y69_RS05080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G7Y69_RS05085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7Y69_RS05090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G7Y69_RS05115	COG2918	glutathione biosynthetic process
G7Y69_RS05120	COG1854	S-ribosylhomocysteine lyase activity
G7Y69_RS05125	COG4536	flavin adenine dinucleotide binding
G7Y69_RS05130	COG4137	Cytochrome C assembly protein
G7Y69_RS05135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G7Y69_RS05140	COG0228	four-way junction DNA binding
G7Y69_RS05150	COG0336	Belongs to the RNA methyltransferase TrmD family
G7Y69_RS05155	COG0335	large ribosomal subunit rRNA binding
G7Y69_RS05160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7Y69_RS05165	COG0287	Prephenate dehydrogenase
G7Y69_RS05165	COG1605	Chorismate mutase
G7Y69_RS05170	COG0840	transmembrane signaling receptor activity
G7Y69_RS05175	COG1605	Chorismate mutase
G7Y69_RS05175	COG0077	Prephenate dehydratase
G7Y69_RS05180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G7Y69_RS05185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7Y69_RS05190	COG0564	pseudouridine synthase activity
G7Y69_RS05200	COG0542	response to heat
G7Y69_RS05230	COG3021	interspecies interaction between organisms
G7Y69_RS05235	COG3738	Protein conserved in bacteria
G7Y69_RS05260	COG0602	queuosine metabolic process
G7Y69_RS05265	COG3477	response to acidic pH
G7Y69_RS05270	COG0720	synthase
G7Y69_RS05275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G7Y69_RS05280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7Y69_RS05290	COG1648	precorrin-2 dehydrogenase activity
G7Y69_RS05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7Y69_RS05295	COG0175	sulfate reduction
G7Y69_RS05300	COG2895	sulfate adenylyltransferase (ATP) activity
G7Y69_RS05305	COG0529	Catalyzes the synthesis of activated sulfate
G7Y69_RS05310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G7Y69_RS05315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G7Y69_RS05320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7Y69_RS05325	COG0585	pseudouridine synthase activity
G7Y69_RS05330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G7Y69_RS05335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7Y69_RS05340	COG1388	LysM domain
G7Y69_RS05340	COG4942	peptidase
G7Y69_RS05355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G7Y69_RS05360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7Y69_RS05360	COG2010	Cytochrome c
G7Y69_RS05365	COG2010	Cytochrome c
G7Y69_RS05365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7Y69_RS05370	COG2080	2 iron, 2 sulfur cluster binding
G7Y69_RS05375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7Y69_RS05375	COG2010	Cytochrome c
G7Y69_RS05390	COG2010	Cytochrome c
G7Y69_RS05390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7Y69_RS05415	COG3961	Belongs to the TPP enzyme family
G7Y69_RS05420	COG0251	oxidation-reduction process
G7Y69_RS05430	COG0583	DNA-binding transcription factor activity
G7Y69_RS05435	COG0786	glutamate:sodium symporter activity
G7Y69_RS05450	COG2252	PERMEase
G7Y69_RS05460	COG0583	DNA-binding transcription factor activity
G7Y69_RS05490	COG4633	Protein conserved in bacteria
G7Y69_RS05505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7Y69_RS05515	COG4566	intracellular signal transduction
G7Y69_RS05530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS05535	COG2962	Rard protein
G7Y69_RS05550	COG1966	Carbon starvation protein
G7Y69_RS05555	COG2879	small protein
G7Y69_RS05560	COG0523	cobalamin synthesis protein
G7Y69_RS05570	COG0534	Mate efflux family protein
G7Y69_RS05575	COG0673	inositol 2-dehydrogenase activity
G7Y69_RS05585	COG5564	TIM-barrel signal transduction protein
G7Y69_RS05590	COG5441	Belongs to the UPF0261 family
G7Y69_RS05610	COG2132	Multicopper oxidase
G7Y69_RS05640	COG3121	Chaperone
G7Y69_RS05650	COG0842	Transport permease protein
G7Y69_RS05655	COG1131	(ABC) transporter
G7Y69_RS05660	COG0288	reversible hydration of carbon dioxide
G7Y69_RS05665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G7Y69_RS05670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G7Y69_RS05675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G7Y69_RS05680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G7Y69_RS05695	COG1489	DNA binding
G7Y69_RS05700	COG1643	Atp-dependent helicase
G7Y69_RS05705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7Y69_RS05710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G7Y69_RS05725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7Y69_RS05735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7Y69_RS05740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7Y69_RS05745	COG3956	TIGRFAM MazG family protein
G7Y69_RS05750	COG0504	CTP synthase activity
G7Y69_RS05755	COG0148	phosphopyruvate hydratase activity
G7Y69_RS05765	COG0471	metal ion transport
G7Y69_RS05770	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G7Y69_RS05770	COG3210	domain, Protein
G7Y69_RS05770	COG3064	Membrane
G7Y69_RS05780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7Y69_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7Y69_RS05790	COG1309	transcriptional regulator
G7Y69_RS05795	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G7Y69_RS05800	COG3264	Mechanosensitive ion channel
G7Y69_RS05800	COG1196	nuclear chromosome segregation
G7Y69_RS05815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G7Y69_RS05820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G7Y69_RS05825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G7Y69_RS05830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G7Y69_RS05835	COG0326	Molecular chaperone. Has ATPase activity
G7Y69_RS05840	COG0563	adenylate kinase activity
G7Y69_RS05850	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G7Y69_RS05855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS05860	COG3192	ethanolamine utilization protein
G7Y69_RS05865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7Y69_RS05880	COG1349	DNA-binding transcription factor activity
G7Y69_RS05890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G7Y69_RS05890	COG4651	solute:proton antiporter activity
G7Y69_RS05895	COG2223	nitrite transmembrane transporter activity
G7Y69_RS05900	COG0737	Belongs to the 5'-nucleotidase family
G7Y69_RS05910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G7Y69_RS05915	COG3735	TraB family
G7Y69_RS05920	COG3247	response to pH
G7Y69_RS05925	COG2217	Heavy metal translocating P-type atpase
G7Y69_RS05935	COG1585	Membrane protein implicated in regulation of membrane protease activity
G7Y69_RS05945	COG3118	belongs to the thioredoxin family
G7Y69_RS05950	COG0300	oxidoreductase activity
G7Y69_RS05955	COG2755	lipolytic protein G-D-S-L family
G7Y69_RS05960	COG4181	ATPase activity
G7Y69_RS05965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G7Y69_RS05980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G7Y69_RS05985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G7Y69_RS05990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7Y69_RS05995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G7Y69_RS06000	COG0215	cysteine-tRNA ligase activity
G7Y69_RS06005	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
G7Y69_RS06005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y69_RS06005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y69_RS06010	COG1105	Belongs to the carbohydrate kinase PfkB family
G7Y69_RS06015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS06015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS06020	COG2501	S4 domain
G7Y69_RS06025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G7Y69_RS06035	COG0582	viral genome integration into host DNA
G7Y69_RS06085	COG0640	Transcriptional regulator
G7Y69_RS06090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G7Y69_RS06105	COG2197	response regulator
G7Y69_RS06125	COG3539	Fimbrial protein
G7Y69_RS06160	COG1473	amidohydrolase
G7Y69_RS06220	COG3005	denitrification pathway
G7Y69_RS06225	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS06230	COG1879	ABC-type sugar transport system periplasmic component
G7Y69_RS06235	COG2198	Histidine kinase
G7Y69_RS06235	COG2205	protein histidine kinase activity
G7Y69_RS06235	COG0784	Response regulator, receiver
G7Y69_RS06240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G7Y69_RS06245	COG0402	S-adenosylhomocysteine deaminase activity
G7Y69_RS06250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G7Y69_RS06255	COG0583	DNA-binding transcription factor activity
G7Y69_RS06265	COG0513	Belongs to the DEAD box helicase family
G7Y69_RS06275	COG1288	antiporter activity
G7Y69_RS06285	COG0626	cystathionine gamma-synthase activity
G7Y69_RS06295	COG0626	cystathionine gamma-synthase activity
G7Y69_RS06300	COG3381	protein complex oligomerization
G7Y69_RS06305	COG3302	dmso reductase anchor subunit
G7Y69_RS06310	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS06315	COG0243	molybdopterin cofactor binding
G7Y69_RS06320	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
G7Y69_RS06330	COG0583	DNA-binding transcription factor activity
G7Y69_RS06340	COG0443	Heat shock 70 kDa protein
G7Y69_RS06350	COG4235	cytochrome complex assembly
G7Y69_RS06355	COG1138	Cytochrome C-type biogenesis protein
G7Y69_RS06360	COG3301	Polysulphide reductase, NrfD
G7Y69_RS06365	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS06370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
G7Y69_RS06380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
G7Y69_RS06380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G7Y69_RS06385	COG3062	negative regulation of establishment of protein localization
G7Y69_RS06395	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS06400	COG0348	domain, Protein
G7Y69_RS06405	COG3043	anaerobic respiration
G7Y69_RS06410	COG3005	denitrification pathway
G7Y69_RS06415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7Y69_RS06420	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7Y69_RS06430	COG1138	Cytochrome C-type biogenesis protein
G7Y69_RS06435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7Y69_RS06440	COG3088	subunit of a heme lyase
G7Y69_RS06440	COG4235	cytochrome complex assembly
G7Y69_RS06460	COG3708	Transcriptional regulator
G7Y69_RS06460	COG2207	Transcriptional regulator
G7Y69_RS06490	COG0673	inositol 2-dehydrogenase activity
G7Y69_RS06495	COG2814	Major facilitator Superfamily
G7Y69_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS06520	COG3718	enzyme involved in inositol metabolism
G7Y69_RS06545	COG3038	cytochrome b561
G7Y69_RS06550	COG2353	YceI-like domain
G7Y69_RS06575	COG1151	hydroxylamine reductase activity
G7Y69_RS06580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7Y69_RS06590	COG2239	Acts as a magnesium transporter
G7Y69_RS06595	COG3091	SprT-like family
G7Y69_RS06600	COG0640	Transcriptional regulator
G7Y69_RS06615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G7Y69_RS06625	COG1166	arginine decarboxylase activity
G7Y69_RS06630	COG0010	Belongs to the arginase family
G7Y69_RS06650	COG0861	Integral membrane protein TerC family
G7Y69_RS06655	COG3066	DNA modification
G7Y69_RS06660	COG4533	DNA binding
G7Y69_RS06670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G7Y69_RS06680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7Y69_RS06695	COG1022	Amp-dependent synthetase and ligase
G7Y69_RS06700	COG0028	Belongs to the TPP enzyme family
G7Y69_RS06715	COG2001	Belongs to the MraZ family
G7Y69_RS06720	COG0275	rRNA processing
G7Y69_RS06725	COG3116	cell division
G7Y69_RS06730	COG0768	penicillin binding
G7Y69_RS06735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7Y69_RS06740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G7Y69_RS06745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7Y69_RS06750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G7Y69_RS06755	COG0772	Belongs to the SEDS family
G7Y69_RS06760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7Y69_RS06765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7Y69_RS06770	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7Y69_RS06775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G7Y69_RS06780	COG0849	cell division
G7Y69_RS06785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G7Y69_RS06790	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G7Y69_RS06805	COG0653	protein targeting
G7Y69_RS06810	COG0494	nUDIX hydrolase
G7Y69_RS06820	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G7Y69_RS06825	COG0237	dephospho-CoA kinase activity
G7Y69_RS06835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7Y69_RS06840	COG4969	Belongs to the N-Me-Phe pilin family
G7Y69_RS06845	COG3023	N-Acetylmuramoyl-L-alanine amidase
G7Y69_RS06855	COG2186	Transcriptional regulator
G7Y69_RS06860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G7Y69_RS06865	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7Y69_RS06870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7Y69_RS06960	COG3112	Uncharacterised protein family (UPF0231)
G7Y69_RS06965	COG0668	transmembrane transport
G7Y69_RS06970	COG1279	arginine transmembrane transporter activity
G7Y69_RS06980	COG0583	DNA-binding transcription factor activity
G7Y69_RS06985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G7Y69_RS06990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7Y69_RS06995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G7Y69_RS07005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
G7Y69_RS07010	COG3079	Belongs to the UPF0149 family
G7Y69_RS07015	COG0006	proline dipeptidase activity
G7Y69_RS07020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7Y69_RS07025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7Y69_RS07030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G7Y69_RS07035	COG0509	glycine decarboxylation via glycine cleavage system
G7Y69_RS07040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7Y69_RS07040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7Y69_RS07055	COG0354	folic acid binding
G7Y69_RS07060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G7Y69_RS07070	COG0716	FMN binding
G7Y69_RS07080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7Y69_RS07085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G7Y69_RS07095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G7Y69_RS07130	COG0589	response to stress
G7Y69_RS07140	COG2017	converts alpha-aldose to the beta-anomer
G7Y69_RS07145	COG2079	MmgE PrpD family protein
G7Y69_RS07150	COG0372	Belongs to the citrate synthase family
G7Y69_RS07155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G7Y69_RS07185	COG3781	membrane
G7Y69_RS07215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G7Y69_RS07220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7Y69_RS07225	COG4558	Periplasmic binding protein
G7Y69_RS07230	COG3720	iron ion transport
G7Y69_RS07240	COG4256	Hemin uptake protein
G7Y69_RS07245	COG0702	epimerase
G7Y69_RS07250	COG2271	Major facilitator Superfamily
G7Y69_RS07265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G7Y69_RS07270	COG2017	converts alpha-aldose to the beta-anomer
G7Y69_RS07275	COG1609	Transcriptional regulator
G7Y69_RS07285	COG4774	siderophore transport
G7Y69_RS07290	COG1120	ATPase activity
G7Y69_RS07315	COG2211	Major facilitator Superfamily
G7Y69_RS07320	COG0673	inositol 2-dehydrogenase activity
G7Y69_RS07330	COG0673	inositol 2-dehydrogenase activity
G7Y69_RS07365	COG2246	polysaccharide biosynthetic process
G7Y69_RS07450	COG0582	viral genome integration into host DNA
G7Y69_RS07455	COG4974	Belongs to the 'phage' integrase family
G7Y69_RS07520	COG4695	Portal protein
G7Y69_RS07655	COG2867	negative regulation of translational initiation
G7Y69_RS07660	COG2914	Belongs to the UPF0125 (RnfH) family
G7Y69_RS07665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7Y69_RS07670	COG0497	DNA recombination
G7Y69_RS07675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G7Y69_RS07680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G7Y69_RS07685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G7Y69_RS07700	COG0513	Belongs to the DEAD box helicase family
G7Y69_RS07705	COG0786	glutamate:sodium symporter activity
G7Y69_RS07720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G7Y69_RS07725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G7Y69_RS07745	COG3086	response to oxidative stress
G7Y69_RS07765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G7Y69_RS07770	COG1381	Involved in DNA repair and RecF pathway recombination
G7Y69_RS07775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G7Y69_RS07785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G7Y69_RS07805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G7Y69_RS07810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G7Y69_RS07810	COG0047	phosphoribosylformylglycinamidine synthase activity
G7Y69_RS07815	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
G7Y69_RS07820	COG0561	phosphatase activity
G7Y69_RS07855	COG3842	ATPase activity
G7Y69_RS07865	COG1840	ABC-type Fe3 transport system, periplasmic component
G7Y69_RS07870	COG2271	Major facilitator Superfamily
G7Y69_RS07890	COG2205	protein histidine kinase activity
G7Y69_RS07895	COG3170	Tfp pilus assembly protein FimV
G7Y69_RS07900	COG2204	response regulator
G7Y69_RS07905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G7Y69_RS07905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7Y69_RS07910	COG0347	Belongs to the P(II) protein family
G7Y69_RS07915	COG1017	nitric oxide dioxygenase activity
G7Y69_RS07915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7Y69_RS07920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G7Y69_RS07925	COG2814	Major facilitator Superfamily
G7Y69_RS07930	COG3121	Chaperone
G7Y69_RS07945	COG3121	Chaperone
G7Y69_RS07955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G7Y69_RS07965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G7Y69_RS07975	COG1802	Transcriptional regulator
G7Y69_RS07980	COG1063	alcohol dehydrogenase
G7Y69_RS07985	COG0483	inositol monophosphate 1-phosphatase activity
G7Y69_RS07990	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
G7Y69_RS07995	COG1959	2 iron, 2 sulfur cluster binding
G7Y69_RS08000	COG1104	cysteine desulfurase activity
G7Y69_RS08005	COG0822	iron-sulfur transferase activity
G7Y69_RS08010	COG0316	Belongs to the HesB IscA family
G7Y69_RS08020	COG0443	Heat shock 70 kDa protein
G7Y69_RS08025	COG0633	Ferredoxin
G7Y69_RS08040	COG2975	iron-sulfur cluster assembly
G7Y69_RS08045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G7Y69_RS08060	COG4953	penicillin-binding protein 1C
G7Y69_RS08065	COG0105	UTP biosynthetic process
G7Y69_RS08070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G7Y69_RS08085	COG0124	histidyl-tRNA synthetase
G7Y69_RS08090	COG2976	Protein conserved in bacteria
G7Y69_RS08095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7Y69_RS08105	COG1187	pseudouridine synthase activity
G7Y69_RS08115	COG0408	coproporphyrinogen oxidase activity
G7Y69_RS08120	COG0456	acetyltransferase
G7Y69_RS08130	COG2837	iron assimilation
G7Y69_RS08145	COG4150	thiosulfate binding
G7Y69_RS08155	COG4208	sulfate ABC transporter
G7Y69_RS08160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G7Y69_RS08165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G7Y69_RS08170	COG2190	(PTS) system
G7Y69_RS08175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7Y69_RS08180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS08195	COG3115	cell septum assembly
G7Y69_RS08200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7Y69_RS08205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G7Y69_RS08210	COG3530	Putative quorum-sensing-regulated virulence factor
G7Y69_RS08225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7Y69_RS08255	COG1396	sequence-specific DNA binding
G7Y69_RS08265	COG2011	ABC-type metal ion transport system permease component
G7Y69_RS08270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G7Y69_RS08275	COG2072	flavoprotein involved in K transport
G7Y69_RS08300	COG2213	PTS system mannitol-specific
G7Y69_RS08300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS08310	COG3722	fumarate hydratase activity
G7Y69_RS08340	COG2067	long-chain fatty acid transport protein
G7Y69_RS08345	COG3691	Protein conserved in bacteria
G7Y69_RS08350	COG0183	Belongs to the thiolase family
G7Y69_RS08355	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7Y69_RS08355	COG1024	Enoyl-CoA hydratase
G7Y69_RS08360	COG2062	phosphohistidine phosphatase, SixA
G7Y69_RS08365	COG2840	Smr protein MutS2
G7Y69_RS08370	COG1228	amidohydrolase
G7Y69_RS08380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G7Y69_RS08385	COG2986	histidine ammonia-lyase
G7Y69_RS08400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G7Y69_RS08405	COG0730	response to heat
G7Y69_RS08410	COG3101	peptidyl-lysine hydroxylation
G7Y69_RS08425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7Y69_RS08425	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G7Y69_RS08430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7Y69_RS08460	COG0642	Histidine kinase
G7Y69_RS08480	COG0697	spore germination
G7Y69_RS08485	COG2207	Transcriptional regulator
G7Y69_RS08490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7Y69_RS08495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G7Y69_RS08500	COG0101	tRNA pseudouridine synthase activity
G7Y69_RS08505	COG0586	Pfam SNARE associated Golgi protein
G7Y69_RS08510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G7Y69_RS08515	COG0285	dihydrofolate synthase activity
G7Y69_RS08520	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
G7Y69_RS08525	COG1286	toxin biosynthetic process
G7Y69_RS08530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G7Y69_RS08535	COG3878	Protein conserved in bacteria
G7Y69_RS08545	COG1090	epimerase
G7Y69_RS08550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G7Y69_RS08565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7Y69_RS08570	COG0280	phosphate acetyltransferase
G7Y69_RS08570	COG0857	belongs to the CobB CobQ family
G7Y69_RS08575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G7Y69_RS08580	COG3092	negative regulation of chromosome organization
G7Y69_RS08585	COG3013	Belongs to the UPF0304 family
G7Y69_RS08615	COG3501	Rhs element vgr protein
G7Y69_RS08625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7Y69_RS08630	COG0490	domain, Protein
G7Y69_RS08630	COG0471	metal ion transport
G7Y69_RS08645	COG0436	Aminotransferase
G7Y69_RS08650	COG0583	DNA-binding transcription factor activity
G7Y69_RS08655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7Y69_RS08665	COG0649	NAD binding
G7Y69_RS08665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7Y69_RS08675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G7Y69_RS08685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G7Y69_RS08690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7Y69_RS08695	COG0839	Belongs to the complex I subunit 6 family
G7Y69_RS08700	COG0713	ATP synthesis coupled electron transport
G7Y69_RS08705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G7Y69_RS08710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7Y69_RS08715	COG1007	ATP synthesis coupled electron transport
G7Y69_RS08730	COG1169	isochorismate synthase
G7Y69_RS08735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G7Y69_RS08745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G7Y69_RS08750	COG1441	menaquinone biosynthetic process
G7Y69_RS08770	COG5464	transposase or invertase
G7Y69_RS08775	COG0814	amino acid
G7Y69_RS08780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G7Y69_RS08785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7Y69_RS08790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7Y69_RS08795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7Y69_RS08800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7Y69_RS08810	COG0784	Response regulator, receiver
G7Y69_RS08810	COG2205	protein histidine kinase activity
G7Y69_RS08820	COG2198	Histidine kinase
G7Y69_RS08820	COG0642	Histidine kinase
G7Y69_RS08835	COG1560	Kdo2-lipid A biosynthetic process
G7Y69_RS08840	COG1301	dicarboxylic acid transport
G7Y69_RS08850	COG1914	H( )-stimulated, divalent metal cation uptake system
G7Y69_RS08855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7Y69_RS08860	COG4336	lyase activity
G7Y69_RS08870	COG4770	biotin carboxylase activity
G7Y69_RS08885	COG3381	protein complex oligomerization
G7Y69_RS08890	COG3302	dmso reductase anchor subunit
G7Y69_RS08895	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS08900	COG0243	molybdopterin cofactor binding
G7Y69_RS08905	COG0668	transmembrane transport
G7Y69_RS08920	COG1335	isochorismatase
G7Y69_RS08950	COG2226	methyltransferase
G7Y69_RS08965	COG3083	sulfuric ester hydrolase activity
G7Y69_RS08970	COG3082	Protein of unknown function (DUF1414)
G7Y69_RS08975	COG3081	Nucleoid-associated protein
G7Y69_RS08980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G7Y69_RS08985	COG1061	Type III restriction enzyme res subunit
G7Y69_RS08990	COG1187	pseudouridine synthase activity
G7Y69_RS08995	COG2814	Major facilitator Superfamily
G7Y69_RS09005	COG0791	NLP P60 protein
G7Y69_RS09020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7Y69_RS09025	COG0814	amino acid
G7Y69_RS09035	COG1105	Belongs to the carbohydrate kinase PfkB family
G7Y69_RS09040	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G7Y69_RS09045	COG2855	membrane
G7Y69_RS09050	COG0583	DNA-binding transcription factor activity
G7Y69_RS09055	COG0833	amino acid
G7Y69_RS09065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7Y69_RS09070	COG1120	ATPase activity
G7Y69_RS09090	COG0277	FAD linked oxidase domain protein
G7Y69_RS09095	COG2925	Exonuclease
G7Y69_RS09100	COG2211	Major facilitator Superfamily
G7Y69_RS09105	COG2926	Belongs to the UPF0265 family
G7Y69_RS09115	COG0243	molybdopterin cofactor binding
G7Y69_RS09120	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS09135	COG1530	ribonuclease E activity
G7Y69_RS09135	COG1530	ribonuclease E activity
G7Y69_RS09140	COG0564	pseudouridine synthase activity
G7Y69_RS09145	COG0424	maF-like protein
G7Y69_RS09150	COG1399	metal-binding, possibly nucleic acid-binding protein
G7Y69_RS09155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G7Y69_RS09160	COG0416	fatty acid biosynthetic process
G7Y69_RS09165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G7Y69_RS09170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G7Y69_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7Y69_RS09185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7Y69_RS09190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G7Y69_RS09195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G7Y69_RS09200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G7Y69_RS09205	COG0470	DNA polymerase III
G7Y69_RS09210	COG0084	hydrolase, TatD family'
G7Y69_RS09215	COG0537	adenosine 5'-monophosphoramidase activity
G7Y69_RS09225	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
G7Y69_RS09230	COG0510	thiamine kinase activity
G7Y69_RS09235	COG1472	Belongs to the glycosyl hydrolase 3 family
G7Y69_RS09245	COG0737	Belongs to the 5'-nucleotidase family
G7Y69_RS09250	COG1252	NADH dehydrogenase
G7Y69_RS09260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G7Y69_RS09265	COG4591	ABC-type transport system involved in lipoprotein release permease component
G7Y69_RS09270	COG1136	(ABC) transporter
G7Y69_RS09275	COG4591	ABC-type transport system involved in lipoprotein release permease component
G7Y69_RS09285	COG2862	Uncharacterized protein family, UPF0114
G7Y69_RS09295	COG0300	oxidoreductase activity
G7Y69_RS09305	COG1280	lysine exporter protein (LysE YggA)
G7Y69_RS09310	COG2850	peptidyl-arginine hydroxylation
G7Y69_RS09320	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS09330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G7Y69_RS09335	COG2915	High frequency lysogenization protein hflD homolog
G7Y69_RS09340	COG0482	sulfurtransferase activity
G7Y69_RS09350	COG1187	pseudouridine synthase activity
G7Y69_RS09355	COG0538	isocitrate dehydrogenase activity
G7Y69_RS09430	COG1396	sequence-specific DNA binding
G7Y69_RS09435	COG2315	Protein conserved in bacteria
G7Y69_RS09445	COG0384	phenazine biosynthesis protein PhzF
G7Y69_RS09465	COG0840	transmembrane signaling receptor activity
G7Y69_RS09480	COG2226	methyltransferase
G7Y69_RS09495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G7Y69_RS09530	COG1115	amino acid carrier protein
G7Y69_RS09540	COG0561	phosphatase activity
G7Y69_RS09545	COG2207	Transcriptional regulator
G7Y69_RS09555	COG1113	amino acid transport
G7Y69_RS09565	COG1328	CTP reductase activity
G7Y69_RS09570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G7Y69_RS09580	COG1597	lipid kinase activity
G7Y69_RS09590	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS09595	COG2205	protein histidine kinase activity
G7Y69_RS09600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7Y69_RS09605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7Y69_RS09610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7Y69_RS09620	COG2239	Acts as a magnesium transporter
G7Y69_RS09630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G7Y69_RS09635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7Y69_RS09640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G7Y69_RS09645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G7Y69_RS09650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G7Y69_RS09655	COG2233	PERMEase
G7Y69_RS09660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7Y69_RS09665	COG1393	Belongs to the ArsC family
G7Y69_RS09670	COG4783	chaperone-mediated protein folding
G7Y69_RS09675	COG0628	permease
G7Y69_RS09680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G7Y69_RS09685	COG2716	regulation of RNA biosynthetic process
G7Y69_RS09695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G7Y69_RS09700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G7Y69_RS09705	COG1122	ATPase activity
G7Y69_RS09710	COG1122	ATPase activity
G7Y69_RS09730	COG2707	UPF0756 membrane protein
G7Y69_RS09735	COG1444	tRNA N-acetyltransferase activity
G7Y69_RS09750	COG2832	Protein of unknown function (DUF454)
G7Y69_RS09755	COG1876	peptidase activity
G7Y69_RS09760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7Y69_RS09765	COG1393	Belongs to the ArsC family
G7Y69_RS09770	COG2197	response regulator
G7Y69_RS09775	COG0281	malic enzyme
G7Y69_RS09775	COG0280	phosphate acetyltransferase
G7Y69_RS09790	COG1770	oligopeptidase
G7Y69_RS09795	COG4206	TonB-dependent receptor
G7Y69_RS09795	COG1629	transport
G7Y69_RS09800	COG1570	exodeoxyribonuclease VII activity
G7Y69_RS09810	COG0516	GMP reductase activity
G7Y69_RS09810	COG0517	IMP dehydrogenase activity
G7Y69_RS09815	COG0519	Catalyzes the synthesis of GMP from XMP
G7Y69_RS09815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7Y69_RS09820	COG0386	Belongs to the glutathione peroxidase family
G7Y69_RS09830	COG0667	Aldo Keto reductase
G7Y69_RS09835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7Y69_RS09845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G7Y69_RS09855	COG2226	methyltransferase
G7Y69_RS09860	COG1971	Probably functions as a manganese efflux pump
G7Y69_RS09865	COG4811	Protein of unknown function (DUF986)
G7Y69_RS09870	COG3716	PTS system mannose fructose sorbose family IID component
G7Y69_RS09875	COG3715	PTS system
G7Y69_RS09880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS09880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS09885	COG1760	l-serine dehydratase
G7Y69_RS09890	COG0494	nUDIX hydrolase
G7Y69_RS09895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G7Y69_RS09900	COG3140	Belongs to the UPF0181 family
G7Y69_RS09915	COG1528	Iron-storage protein
G7Y69_RS09920	COG2372	response to copper ion
G7Y69_RS09925	COG1276	copper resistance
G7Y69_RS09945	COG3008	intermembrane lipid transfer
G7Y69_RS09950	COG2995	paraquat-inducible protein a
G7Y69_RS09955	COG1956	GAF domain-containing protein
G7Y69_RS09960	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
G7Y69_RS09975	COG0501	Belongs to the peptidase M48B family
G7Y69_RS09980	COG1115	amino acid carrier protein
G7Y69_RS09995	COG2814	Major facilitator Superfamily
G7Y69_RS10015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G7Y69_RS10020	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7Y69_RS10025	COG2186	Transcriptional regulator
G7Y69_RS10030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7Y69_RS10035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7Y69_RS10040	COG3713	MltA-interacting MipA family protein
G7Y69_RS10060	COG3139	Protein of unknown function (DUF1315)
G7Y69_RS10065	COG1335	isochorismatase
G7Y69_RS10070	COG0252	asparaginase activity
G7Y69_RS10075	COG0616	signal peptide processing
G7Y69_RS10080	COG0778	Nitroreductase
G7Y69_RS10085	COG0709	Synthesizes selenophosphate from selenide and ATP
G7Y69_RS10090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G7Y69_RS10095	COG0708	Exodeoxyribonuclease III
G7Y69_RS10100	COG0583	DNA-binding transcription factor activity
G7Y69_RS10110	COG0788	formyltetrahydrofolate deformylase activity
G7Y69_RS10115	COG3012	SEC-C Motif Domain Protein
G7Y69_RS10120	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS10125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G7Y69_RS10130	COG2916	Histone family protein nucleoid-structuring protein H-NS
G7Y69_RS10135	COG1435	thymidine kinase activity
G7Y69_RS10140	COG1454	alcohol dehydrogenase
G7Y69_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS10145	COG2095	MarC family integral membrane protein
G7Y69_RS10160	COG0601	transmembrane transport
G7Y69_RS10165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7Y69_RS10175	COG4608	Belongs to the ABC transporter superfamily
G7Y69_RS10185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7Y69_RS10195	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
G7Y69_RS10210	COG2917	probably involved in intracellular septation
G7Y69_RS10225	COG3047	cAMP biosynthetic process
G7Y69_RS10230	COG2831	hemolysin activation secretion protein
G7Y69_RS10235	COG3210	domain, Protein
G7Y69_RS10240	COG0159	tryptophan synthase activity
G7Y69_RS10245	COG0133	tryptophan synthase activity
G7Y69_RS10250	COG0135	phosphoribosylanthranilate isomerase activity
G7Y69_RS10250	COG0134	indole-3-glycerol-phosphate synthase activity
G7Y69_RS10255	COG0512	Glutamine amidotransferase of anthranilate synthase
G7Y69_RS10255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7Y69_RS10260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7Y69_RS10260	COG0512	Glutamine amidotransferase of anthranilate synthase
G7Y69_RS10275	COG0009	L-threonylcarbamoyladenylate synthase
G7Y69_RS10280	COG1187	pseudouridine synthase activity
G7Y69_RS10285	COG3700	Belongs to the class B bacterial acid phosphatase family
G7Y69_RS10290	COG3210	domain, Protein
G7Y69_RS10295	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G7Y69_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS10305	COG0616	signal peptide processing
G7Y69_RS10315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G7Y69_RS10325	COG3590	peptidase
G7Y69_RS10330	COG0583	DNA-binding transcription factor activity
G7Y69_RS10345	COG0113	porphobilinogen synthase activity
G7Y69_RS10350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G7Y69_RS10355	COG0671	phosphoesterase, PA-phosphatase related
G7Y69_RS10360	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
G7Y69_RS10365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G7Y69_RS10370	COG0284	orotidine-5'-phosphate decarboxylase activity
G7Y69_RS10375	COG0023	Translation Initiation Factor
G7Y69_RS10385	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G7Y69_RS10395	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
G7Y69_RS10400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G7Y69_RS10410	COG4659	FMN binding
G7Y69_RS10420	COG4656	Part of a membrane complex involved in electron transport
G7Y69_RS10430	COG4657	Part of a membrane complex involved in electron transport
G7Y69_RS10440	COG0673	inositol 2-dehydrogenase activity
G7Y69_RS10445	COG0385	Bile acid
G7Y69_RS10450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G7Y69_RS10455	COG5339	Protein conserved in bacteria
G7Y69_RS10460	COG1482	cell wall glycoprotein biosynthetic process
G7Y69_RS10465	COG0114	fumarate hydratase activity
G7Y69_RS10475	COG3397	chitin binding
G7Y69_RS10480	COG2814	Major facilitator Superfamily
G7Y69_RS10485	COG0583	DNA-binding transcription factor activity
G7Y69_RS10490	COG1940	carbohydrate kinase activity
G7Y69_RS10495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G7Y69_RS10520	COG0210	DNA helicase
G7Y69_RS10530	COG2801	Transposase and inactivated derivatives
G7Y69_RS10730	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G7Y69_RS10735	COG1280	lysine exporter protein (LysE YggA)
G7Y69_RS10740	COG1671	Belongs to the UPF0178 family
G7Y69_RS10755	COG1309	transcriptional regulator
G7Y69_RS10775	COG0697	spore germination
G7Y69_RS10780	COG1846	Transcriptional regulator
G7Y69_RS10790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G7Y69_RS10800	COG0714	Associated with various cellular activities
G7Y69_RS10805	COG3831	ATPase activity
G7Y69_RS10810	COG0251	oxidation-reduction process
G7Y69_RS10845	COG1979	alcohol dehydrogenase
G7Y69_RS10850	COG2814	Major facilitator Superfamily
G7Y69_RS10855	COG2814	Major facilitator Superfamily
G7Y69_RS10860	COG2211	Major facilitator Superfamily
G7Y69_RS10865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7Y69_RS10865	COG2169	Transcriptional regulator
G7Y69_RS10885	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G7Y69_RS10895	COG0702	epimerase
G7Y69_RS10925	COG2223	nitrite transmembrane transporter activity
G7Y69_RS10945	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7Y69_RS10980	COG4807	Protein conserved in bacteria
G7Y69_RS10985	COG5642	Protein of unknown function (DUF2384)
G7Y69_RS10990	COG5654	RES domain protein
G7Y69_RS10995	COG0583	DNA-binding transcription factor activity
G7Y69_RS11000	COG0825	malonyl-CoA metabolic process
G7Y69_RS11015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7Y69_RS11030	COG0765	amino acid transport
G7Y69_RS11035	COG1126	abc transporter atp-binding protein
G7Y69_RS11060	COG1403	HNH endonuclease
G7Y69_RS11075	COG3634	alkyl hydroperoxide reductase activity
G7Y69_RS11085	COG0842	Transport permease protein
G7Y69_RS11090	COG0842	Transport permease protein
G7Y69_RS11090	COG1129	ABC transporter
G7Y69_RS11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7Y69_RS11120	COG0814	amino acid
G7Y69_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS11130	COG0604	alcohol dehydrogenase
G7Y69_RS11130	COG3321	synthase
G7Y69_RS11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7Y69_RS11140	COG0589	response to stress
G7Y69_RS11145	COG1309	transcriptional regulator
G7Y69_RS11155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G7Y69_RS11160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G7Y69_RS11170	COG0531	amino acid
G7Y69_RS11175	COG1643	Atp-dependent helicase
G7Y69_RS11185	COG3784	Protein of unknown function (DUF1318)
G7Y69_RS11195	COG2911	Protein conserved in bacteria
G7Y69_RS11200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7Y69_RS11210	COG2999	glutathione oxidoreductase activity
G7Y69_RS11245	COG3042	response to heat
G7Y69_RS11255	COG2983	Belongs to the UPF0260 family
G7Y69_RS11260	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7Y69_RS11265	COG2951	lytic endotransglycosylase activity
G7Y69_RS11270	COG3100	YcgL domain-containing protein
G7Y69_RS11275	COG0850	regulation of cytokinetic process
G7Y69_RS11280	COG2894	cell division
G7Y69_RS11285	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G7Y69_RS11315	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y69_RS11325	COG3065	identical protein binding
G7Y69_RS11335	COG1199	ATP-dependent helicase activity
G7Y69_RS11340	COG0251	oxidation-reduction process
G7Y69_RS11345	COG2076	Multidrug Resistance protein
G7Y69_RS11350	COG2076	Multidrug Resistance protein
G7Y69_RS11360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G7Y69_RS11365	COG1737	Transcriptional regulator
G7Y69_RS11370	COG0469	pyruvate kinase activity
G7Y69_RS11395	COG0583	DNA-binding transcription factor activity
G7Y69_RS11400	COG1560	Kdo2-lipid A biosynthetic process
G7Y69_RS11405	COG0739	heme binding
G7Y69_RS11410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
G7Y69_RS11415	COG1121	(ABC) transporter
G7Y69_RS11420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7Y69_RS11425	COG2255	four-way junction helicase activity
G7Y69_RS11430	COG0632	four-way junction helicase activity
G7Y69_RS11435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G7Y69_RS11440	COG0217	transcriptional regulatory protein
G7Y69_RS11445	COG0494	nUDIX hydrolase
G7Y69_RS11450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G7Y69_RS11465	COG3788	relative of glutathione S-transferase, MAPEG superfamily
G7Y69_RS11470	COG2226	methyltransferase
G7Y69_RS11475	COG0500	methyltransferase
G7Y69_RS11480	COG3302	dmso reductase anchor subunit
G7Y69_RS11485	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS11490	COG0243	molybdopterin cofactor binding
G7Y69_RS11495	COG3142	Participates in the control of copper homeostasis
G7Y69_RS11500	COG3102	Protein conserved in bacteria
G7Y69_RS11505	COG0018	arginyl-trna synthetase
G7Y69_RS11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7Y69_RS11530	COG0477	Major facilitator Superfamily
G7Y69_RS11540	COG3381	protein complex oligomerization
G7Y69_RS11545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7Y69_RS11555	COG1115	amino acid carrier protein
G7Y69_RS11560	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS11565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7Y69_RS11570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7Y69_RS11580	COG4977	sequence-specific DNA binding
G7Y69_RS11585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G7Y69_RS11590	COG2267	carboxylic ester hydrolase activity
G7Y69_RS11595	COG0671	phosphoesterase, PA-phosphatase related
G7Y69_RS11595	COG2453	phosphatase
G7Y69_RS11605	COG0659	secondary active sulfate transmembrane transporter activity
G7Y69_RS11615	COG1242	4 iron, 4 sulfur cluster binding
G7Y69_RS11630	COG2890	protein-(glutamine-N5) methyltransferase activity
G7Y69_RS11635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G7Y69_RS11640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G7Y69_RS11645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G7Y69_RS11650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G7Y69_RS11655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7Y69_RS11665	COG0193	aminoacyl-tRNA hydrolase activity
G7Y69_RS11670	COG0012	GTP binding
G7Y69_RS11690	COG3188	usher protein
G7Y69_RS11715	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G7Y69_RS11720	COG0583	DNA-binding transcription factor activity
G7Y69_RS11725	COG3961	Belongs to the TPP enzyme family
G7Y69_RS11740	COG1288	antiporter activity
G7Y69_RS11755	COG4772	TonB-dependent receptor
G7Y69_RS11765	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS11770	COG0243	molybdopterin cofactor binding
G7Y69_RS11790	COG1280	lysine exporter protein (LysE YggA)
G7Y69_RS11800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7Y69_RS11805	COG1271	oxidase subunit
G7Y69_RS11810	COG1294	oxidase, subunit
G7Y69_RS11825	COG2375	cellular response to nickel ion
G7Y69_RS11830	COG3443	Belongs to the bacterial solute-binding protein 9 family
G7Y69_RS11835	COG1702	phosphate starvation-inducible protein PhoH
G7Y69_RS11840	COG2356	endonuclease I
G7Y69_RS11845	COG3610	response to peptide
G7Y69_RS11850	COG2966	Psort location CytoplasmicMembrane, score
G7Y69_RS11870	COG0589	response to stress
G7Y69_RS11880	COG0589	response to stress
G7Y69_RS11890	COG0673	inositol 2-dehydrogenase activity
G7Y69_RS11895	COG0791	NLP P60 protein
G7Y69_RS11910	COG1794	racemase activity, acting on amino acids and derivatives
G7Y69_RS11935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G7Y69_RS11940	COG0037	tRNA processing
G7Y69_RS11945	COG0598	Magnesium transport protein CorA
G7Y69_RS11950	COG4166	transmembrane transport
G7Y69_RS11970	COG3768	UPF0283 membrane protein
G7Y69_RS11975	COG3106	COG3106 Predicted ATPase
G7Y69_RS11980	COG1983	PspC domain protein
G7Y69_RS11990	COG1842	Phage shock protein A
G7Y69_RS11995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G7Y69_RS12005	COG4166	transmembrane transport
G7Y69_RS12015	COG4171	peptide transport system, permease
G7Y69_RS12025	COG4172	Belongs to the ABC transporter superfamily
G7Y69_RS12030	COG3739	integral membrane protein
G7Y69_RS12040	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G7Y69_RS12045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G7Y69_RS12050	COG0259	pyridoxamine-phosphate oxidase activity
G7Y69_RS12055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G7Y69_RS12060	COG3133	Outer membrane lipoprotein
G7Y69_RS12065	COG1846	Transcriptional regulator
G7Y69_RS12070	COG3313	Fe-S protein
G7Y69_RS12075	COG0346	lactoylglutathione lyase activity
G7Y69_RS12080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G7Y69_RS12085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G7Y69_RS12095	COG1609	Transcriptional regulator
G7Y69_RS12100	COG0583	DNA-binding transcription factor activity
G7Y69_RS12105	COG2814	Major facilitator Superfamily
G7Y69_RS12120	COG0307	riboflavin synthase, alpha
G7Y69_RS12125	COG0534	Mate efflux family protein
G7Y69_RS12145	COG0469	pyruvate kinase activity
G7Y69_RS12150	COG4238	major outer membrane lipoprotein
G7Y69_RS12155	COG1376	ErfK ybiS ycfS ynhG family protein
G7Y69_RS12155	COG1388	LysM domain
G7Y69_RS12160	COG2166	iron-sulfur cluster assembly
G7Y69_RS12165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G7Y69_RS12170	COG0719	Fe-S assembly protein
G7Y69_RS12175	COG0396	ATPase activity
G7Y69_RS12180	COG0719	Fe-S assembly protein
G7Y69_RS12185	COG0316	Belongs to the HesB IscA family
G7Y69_RS12190	COG2050	protein possibly involved in aromatic compounds catabolism
G7Y69_RS12195	COG0277	FAD linked oxidase domain protein
G7Y69_RS12195	COG0247	lactate metabolic process
G7Y69_RS12200	COG0628	permease
G7Y69_RS12205	COG0574	Belongs to the PEP-utilizing enzyme family
G7Y69_RS12205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7Y69_RS12210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G7Y69_RS12225	COG3720	iron ion transport
G7Y69_RS12230	COG2207	Transcriptional regulator
G7Y69_RS12240	COG0791	NLP P60 protein
G7Y69_RS12245	COG2076	Multidrug Resistance protein
G7Y69_RS12250	COG2076	Multidrug Resistance protein
G7Y69_RS12255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G7Y69_RS12260	COG0726	polysaccharide deacetylase
G7Y69_RS12265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7Y69_RS12265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7Y69_RS12270	COG0463	Glycosyl transferase, family 2
G7Y69_RS12275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G7Y69_RS12280	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
G7Y69_RS12285	COG4139	cobalamin transport
G7Y69_RS12295	COG0776	regulation of translation
G7Y69_RS12300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7Y69_RS12300	COG0072	phenylalanine-tRNA ligase activity
G7Y69_RS12305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G7Y69_RS12315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G7Y69_RS12320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G7Y69_RS12330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G7Y69_RS12335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G7Y69_RS12370	COG0803	Belongs to the bacterial solute-binding protein 9 family
G7Y69_RS12375	COG1121	(ABC) transporter
G7Y69_RS12380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7Y69_RS12385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7Y69_RS12405	COG0542	response to heat
G7Y69_RS12410	COG3001	Fructosamine kinase
G7Y69_RS12420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7Y69_RS12425	COG1988	membrane-bound metal-dependent
G7Y69_RS12435	COG0727	PFAM Uncharacterised protein family (UPF0153)
G7Y69_RS12440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7Y69_RS12450	COG3422	double-strand break repair
G7Y69_RS12475	COG1473	amidohydrolase
G7Y69_RS12495	COG1070	Carbohydrate kinase
G7Y69_RS12500	COG0246	Mannitol dehydrogenase
G7Y69_RS12515	COG2390	Transcriptional regulator
G7Y69_RS12520	COG1461	Dihydroxyacetone kinase
G7Y69_RS12525	COG2376	Dihydroxyacetone kinase
G7Y69_RS12530	COG2814	Major facilitator Superfamily
G7Y69_RS12535	COG1063	alcohol dehydrogenase
G7Y69_RS12540	COG0698	ribose 5-phosphate isomerase
G7Y69_RS12545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G7Y69_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS12555	COG4619	ABC transporter
G7Y69_RS12560	COG0390	transport system, permease component
G7Y69_RS12575	COG1069	ribulokinase activity
G7Y69_RS12595	COG1609	Transcriptional regulator
G7Y69_RS12610	COG3037	sugar-specific permease SgaT UlaA
G7Y69_RS12620	COG1683	Conserved Protein
G7Y69_RS12655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G7Y69_RS12660	COG1349	DNA-binding transcription factor activity
G7Y69_RS12665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G7Y69_RS12705	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G7Y69_RS12740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G7Y69_RS12745	COG0322	excinuclease ABC activity
G7Y69_RS12750	COG2197	response regulator
G7Y69_RS12755	COG2195	Cleaves the N-terminal amino acid of tripeptides
G7Y69_RS12760	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G7Y69_RS12795	COG1494	fructose-1,6-bisphosphatase
G7Y69_RS12810	COG4565	transcriptional regulatory protein
G7Y69_RS12815	COG3290	protein histidine kinase activity
G7Y69_RS12820	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
G7Y69_RS12830	COG2301	Belongs to the HpcH HpaI aldolase family
G7Y69_RS12835	COG3051	citrate lyase alpha subunit
G7Y69_RS12850	COG0471	metal ion transport
G7Y69_RS12855	COG2828	Protein conserved in bacteria
G7Y69_RS12870	COG2720	vancomycin resistance protein
G7Y69_RS12875	COG2851	Citrate transporter
G7Y69_RS12880	COG1902	pentaerythritol trinitrate reductase activity
G7Y69_RS12900	COG0471	metal ion transport
G7Y69_RS12910	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G7Y69_RS12915	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS12920	COG1309	transcriptional regulator
G7Y69_RS12925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G7Y69_RS12940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS12945	COG0800	Aldolase
G7Y69_RS12970	COG1191	sigma factor activity
G7Y69_RS13000	COG0242	peptide deformylase activity
G7Y69_RS13020	COG5510	response to toxic substance
G7Y69_RS13030	COG1278	Cold shock
G7Y69_RS13040	COG1677	Flagellar hook-basal body complex protein FliE
G7Y69_RS13045	COG1766	The M ring may be actively involved in energy transduction
G7Y69_RS13055	COG1317	bacterial-type flagellum organization
G7Y69_RS13065	COG2882	bacterial-type flagellum organization
G7Y69_RS13075	COG1580	Controls the rotational direction of flagella during chemotaxis
G7Y69_RS13085	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G7Y69_RS13135	COG1706	bacterial-type flagellum-dependent cell motility
G7Y69_RS13140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G7Y69_RS13160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G7Y69_RS13165	COG1558	bacterial-type flagellum-dependent cell motility
G7Y69_RS13170	COG1815	bacterial-type flagellum-dependent cell motility
G7Y69_RS13195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G7Y69_RS13225	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS13230	COG2201	protein-glutamate methylesterase activity
G7Y69_RS13235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G7Y69_RS13240	COG0840	transmembrane signaling receptor activity
G7Y69_RS13250	COG0835	chemotaxis
G7Y69_RS13280	COG1598	PFAM Uncharacterised protein family UPF0150
G7Y69_RS13295	COG1113	amino acid transport
G7Y69_RS13305	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7Y69_RS13305	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7Y69_RS13305	COG0506	proline dehydrogenase activity
G7Y69_RS13325	COG1285	pathogenesis
G7Y69_RS13365	COG0418	dihydroorotase activity
G7Y69_RS13380	COG0071	Belongs to the small heat shock protein (HSP20) family
G7Y69_RS13390	COG3683	transport system, periplasmic component
G7Y69_RS13395	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
G7Y69_RS13425	COG1560	Kdo2-lipid A biosynthetic process
G7Y69_RS13430	COG2814	Major facilitator Superfamily
G7Y69_RS13435	COG3104	oligopeptide transport
G7Y69_RS13455	COG1607	acyl-coa hydrolase
G7Y69_RS13470	COG0519	Catalyzes the synthesis of GMP from XMP
G7Y69_RS13480	COG0456	acetyltransferase
G7Y69_RS13490	COG2864	formate dehydrogenase
G7Y69_RS13495	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS13505	COG1742	UPF0060 membrane protein
G7Y69_RS13520	COG2249	NAD(P)H dehydrogenase (quinone) activity
G7Y69_RS13530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G7Y69_RS13540	COG2005	Transcriptional regulator
G7Y69_RS13540	COG3585	molybdate ion transport
G7Y69_RS13555	COG2388	GCN5-related N-acetyl-transferase
G7Y69_RS13690	COG3501	Rhs element vgr protein
G7Y69_RS13720	COG2920	part of a sulfur-relay system
G7Y69_RS13725	COG1254	Belongs to the acylphosphatase family
G7Y69_RS13730	COG3785	DNA binding
G7Y69_RS13735	COG1832	CoA-binding protein
G7Y69_RS13740	COG1803	Methylglyoxal synthase
G7Y69_RS13745	COG0210	DNA helicase
G7Y69_RS13750	COG1289	transmembrane transporter activity
G7Y69_RS13755	COG3070	regulator of competence-specific genes
G7Y69_RS13760	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
G7Y69_RS13780	COG1067	ATP-dependent peptidase activity
G7Y69_RS13790	COG3130	regulation of translation
G7Y69_RS13795	COG3009	Protein conserved in bacteria
G7Y69_RS13800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G7Y69_RS13800	COG3008	intermembrane lipid transfer
G7Y69_RS13805	COG2995	paraquat-inducible protein a
G7Y69_RS13810	COG0488	(ABC) transporter
G7Y69_RS13815	COG0116	Belongs to the methyltransferase superfamily
G7Y69_RS13815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G7Y69_RS13820	COG0633	Ferredoxin
G7Y69_RS13820	COG3217	Mosc domain protein beta barrel domain protein
G7Y69_RS13830	COG0167	dihydroorotate dehydrogenase activity
G7Y69_RS13835	COG0308	aminopeptidase N
G7Y69_RS13840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G7Y69_RS13845	COG0017	Asparaginyl-tRNA synthetase
G7Y69_RS13850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7Y69_RS13855	COG1448	Aminotransferase
G7Y69_RS13860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7Y69_RS13865	COG3108	Peptidase M15
G7Y69_RS13870	COG2989	Protein conserved in bacteria
G7Y69_RS13880	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
G7Y69_RS13885	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
G7Y69_RS13890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7Y69_RS13895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G7Y69_RS13900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G7Y69_RS13915	COG1663	tetraacyldisaccharide 4'-kinase activity
G7Y69_RS13920	COG1132	(ABC) transporter
G7Y69_RS13925	COG0658	competence protein
G7Y69_RS13925	COG2333	competence protein COMEC
G7Y69_RS13930	COG0776	regulation of translation
G7Y69_RS13935	COG0539	negative regulation of cytoplasmic translation
G7Y69_RS13940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G7Y69_RS13945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G7Y69_RS13950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G7Y69_RS13955	COG0033	Phosphoglucomutase
G7Y69_RS13960	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
G7Y69_RS13965	COG0596	Alpha beta hydrolase
G7Y69_RS13970	COG2274	protein secretion by the type I secretion system
G7Y69_RS13990	COG0716	FMN binding
G7Y69_RS13995	COG0735	belongs to the Fur family
G7Y69_RS14010	COG0252	asparaginase activity
G7Y69_RS14015	COG1944	ATP diphosphatase activity
G7Y69_RS14020	COG2721	sulfolactate sulfo-lyase activity
G7Y69_RS14025	COG2271	Major facilitator Superfamily
G7Y69_RS14030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7Y69_RS14035	COG1414	Transcriptional regulator
G7Y69_RS14040	COG2116	formate transmembrane transporter activity
G7Y69_RS14045	COG1882	Formate acetyltransferase
G7Y69_RS14050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G7Y69_RS14080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G7Y69_RS14085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7Y69_RS14090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G7Y69_RS14095	COG3107	peptidoglycan biosynthetic process
G7Y69_RS14095	COG1674	ftsk spoiiie
G7Y69_RS14100	COG1522	sequence-specific DNA binding
G7Y69_RS14105	COG0492	ferredoxin-NADP+ reductase activity
G7Y69_RS14110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G7Y69_RS14120	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G7Y69_RS14125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G7Y69_RS14130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7Y69_RS14135	COG0542	response to heat
G7Y69_RS14140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G7Y69_RS14145	COG1278	Cold shock
G7Y69_RS14155	COG1414	Transcriptional regulator
G7Y69_RS14160	COG3153	acetyltransferase
G7Y69_RS14160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7Y69_RS14170	COG2186	Transcriptional regulator
G7Y69_RS14175	COG0473	3-isopropylmalate dehydrogenase activity
G7Y69_RS14175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7Y69_RS14180	COG2271	Major facilitator Superfamily
G7Y69_RS14190	COG0577	efflux transmembrane transporter activity
G7Y69_RS14190	COG1136	(ABC) transporter
G7Y69_RS14195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7Y69_RS14200	COG3593	DNA synthesis involved in DNA repair
G7Y69_RS14205	COG2431	L-lysine efflux transmembrane transporter activity
G7Y69_RS14210	COG0702	epimerase
G7Y69_RS14215	COG1126	abc transporter atp-binding protein
G7Y69_RS14220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7Y69_RS14225	COG4215	(ABC) transporter
G7Y69_RS14230	COG4160	amino acid transport
G7Y69_RS14240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7Y69_RS14260	COG0432	Pfam Uncharacterised protein family UPF0047
G7Y69_RS14265	COG0671	phosphoesterase, PA-phosphatase related
G7Y69_RS14270	COG0814	amino acid
G7Y69_RS14275	COG1760	l-serine dehydratase
G7Y69_RS14280	COG1686	Belongs to the peptidase S11 family
G7Y69_RS14285	COG0625	glutathione transferase activity
G7Y69_RS14290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7Y69_RS14300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G7Y69_RS14305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G7Y69_RS14305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G7Y69_RS14310	COG0131	Imidazoleglycerol-phosphate dehydratase
G7Y69_RS14310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G7Y69_RS14320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G7Y69_RS14325	COG0107	imidazoleglycerol-phosphate synthase activity
G7Y69_RS14330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G7Y69_RS14330	COG0140	phosphoribosyl-ATP diphosphatase activity
G7Y69_RS14345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G7Y69_RS14370	COG1253	flavin adenine dinucleotide binding
G7Y69_RS14380	COG2982	Protein involved in outer membrane biogenesis
G7Y69_RS14385	COG0717	Belongs to the dCTP deaminase family
G7Y69_RS14390	COG0572	uridine kinase
G7Y69_RS14395	COG0501	Belongs to the peptidase M48B family
G7Y69_RS14405	COG0489	protein tyrosine kinase activity
G7Y69_RS14410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7Y69_RS14410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7Y69_RS14415	COG1380	Effector of murein hydrolase LrgA
G7Y69_RS14420	COG1346	cytolysis
G7Y69_RS14460	COG0281	malic enzyme
G7Y69_RS14480	COG1263	PTS System
G7Y69_RS14480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS14495	COG2949	membrane
G7Y69_RS14500	COG2311	Membrane
G7Y69_RS14505	COG0302	gtp cyclohydrolase
G7Y69_RS14510	COG0303	'Molybdopterin
G7Y69_RS14515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G7Y69_RS14520	COG2824	Alkylphosphonate utilization operon protein PhnA
G7Y69_RS14525	COG0488	(ABC) transporter
G7Y69_RS14540	COG5006	permease, DMT superfamily
G7Y69_RS14560	COG2897	thiosulfate sulfurtransferase activity
G7Y69_RS14565	COG2261	transglycosylase associated protein
G7Y69_RS14570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7Y69_RS14575	COG0513	Belongs to the DEAD box helicase family
G7Y69_RS14580	COG1309	transcriptional regulator
G7Y69_RS14590	COG1131	(ABC) transporter
G7Y69_RS14595	COG0842	Transport permease protein
G7Y69_RS14600	COG0842	Transport permease protein
G7Y69_RS14605	COG0670	Belongs to the BI1 family
G7Y69_RS14610	COG0314	molybdopterin synthase activity
G7Y69_RS14615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G7Y69_RS14625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G7Y69_RS14635	COG0556	nucleotide-excision repair
G7Y69_RS14645	COG2226	methyltransferase
G7Y69_RS14655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G7Y69_RS14665	COG2706	6-phosphogluconolactonase activity
G7Y69_RS14670	COG0561	phosphatase activity
G7Y69_RS14680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G7Y69_RS14690	COG0477	Major facilitator Superfamily
G7Y69_RS14695	COG0246	Mannitol dehydrogenase
G7Y69_RS14700	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G7Y69_RS14705	COG4149	molybdate abc transporter
G7Y69_RS14710	COG0725	ABC transporter, periplasmic molybdate-binding protein
G7Y69_RS14730	COG2005	Transcriptional regulator
G7Y69_RS14730	COG3585	molybdate ion transport
G7Y69_RS14735	COG1119	ATPase activity
G7Y69_RS14755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS14755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS14755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7Y69_RS14755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS14755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS14755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7Y69_RS14760	COG0383	alpha-mannosidase activity
G7Y69_RS14765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
G7Y69_RS14765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y69_RS14765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y69_RS14770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7Y69_RS14780	COG0588	phosphoglycerate mutase activity
G7Y69_RS14795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7Y69_RS14805	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G7Y69_RS14830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
G7Y69_RS14835	COG2885	chlorophyll binding
G7Y69_RS14840	COG0823	Involved in the tonB-independent uptake of proteins
G7Y69_RS14845	COG3064	Membrane
G7Y69_RS14850	COG0848	biopolymer transport protein
G7Y69_RS14855	COG0811	peptide transport
G7Y69_RS14860	COG0824	Thioesterase
G7Y69_RS14870	COG4890	Cyd operon protein YbgT
G7Y69_RS14875	COG1294	oxidase, subunit
G7Y69_RS14880	COG1271	oxidase subunit
G7Y69_RS14885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G7Y69_RS14890	COG0045	succinate-CoA ligase (ADP-forming) activity
G7Y69_RS14895	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7Y69_RS14900	COG0567	Dehydrogenase, E1 component
G7Y69_RS14910	COG1053	succinate dehydrogenase
G7Y69_RS14915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G7Y69_RS14935	COG2814	Major facilitator Superfamily
G7Y69_RS14940	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G7Y69_RS14970	COG3501	Rhs element vgr protein
G7Y69_RS14980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G7Y69_RS15000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G7Y69_RS15005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G7Y69_RS15010	COG2205	protein histidine kinase activity
G7Y69_RS15015	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS15025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7Y69_RS15045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS15045	COG1263	PTS System
G7Y69_RS15045	COG2190	(PTS) system
G7Y69_RS15050	COG0363	glucosamine-6-phosphate deaminase activity
G7Y69_RS15055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G7Y69_RS15060	COG1846	Transcriptional regulator
G7Y69_RS15060	COG1940	carbohydrate kinase activity
G7Y69_RS15105	COG1301	dicarboxylic acid transport
G7Y69_RS15110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7Y69_RS15115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7Y69_RS15120	COG1702	phosphate starvation-inducible protein PhoH
G7Y69_RS15125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G7Y69_RS15130	COG4535	Mg2 and Co2 transporter CorC
G7Y69_RS15135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G7Y69_RS15160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7Y69_RS15165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7Y69_RS15165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7Y69_RS15185	COG0765	amino acid transport
G7Y69_RS15190	COG0765	amino acid transport
G7Y69_RS15195	COG1126	abc transporter atp-binding protein
G7Y69_RS15200	COG0495	leucyl-tRNA aminoacylation
G7Y69_RS15205	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
G7Y69_RS15210	COG1466	dna polymerase III delta subunit
G7Y69_RS15225	COG0799	negative regulation of ribosome biogenesis
G7Y69_RS15230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G7Y69_RS15235	COG0768	penicillin binding
G7Y69_RS15240	COG0772	Belongs to the SEDS family
G7Y69_RS15245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G7Y69_RS15250	COG1686	Belongs to the peptidase S11 family
G7Y69_RS15255	COG2921	Belongs to the UPF0250 family
G7Y69_RS15260	COG0321	lipoyl(octanoyl) transferase activity
G7Y69_RS15265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G7Y69_RS15270	COG1278	Cold shock
G7Y69_RS15275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7Y69_RS15280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G7Y69_RS15285	COG1780	Probably involved in ribonucleotide reductase function
G7Y69_RS15300	COG4175	Glycine betaine
G7Y69_RS15305	COG4176	ABC-type proline glycine betaine transport system permease component
G7Y69_RS15310	COG2113	Glycine betaine
G7Y69_RS15315	COG2814	Major facilitator Superfamily
G7Y69_RS15320	COG1846	Transcriptional regulator
G7Y69_RS15325	COG1566	PFAM secretion protein HlyD family protein
G7Y69_RS15330	COG2814	Major facilitator Superfamily
G7Y69_RS15335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7Y69_RS15350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7Y69_RS15355	COG5544	Lipoprotein
G7Y69_RS15370	COG0640	Transcriptional regulator
G7Y69_RS15405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G7Y69_RS15410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G7Y69_RS15415	COG2011	ABC-type metal ion transport system permease component
G7Y69_RS15420	COG1464	Belongs to the NlpA lipoprotein family
G7Y69_RS15430	COG1720	tRNA m6t6A37 methyltransferase activity
G7Y69_RS15435	COG0442	prolyl-tRNA aminoacylation
G7Y69_RS15445	COG1486	melibiose metabolic process
G7Y69_RS15450	COG1917	Cupin 2, conserved barrel domain protein
G7Y69_RS15450	COG2169	Transcriptional regulator
G7Y69_RS15455	COG1447	Phosphotransferase system cellobiose-specific component IIA
G7Y69_RS15460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7Y69_RS15465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7Y69_RS15470	COG3015	lipoprotein NlpE involved in copper resistance
G7Y69_RS15475	COG4568	rho-dependent transcription termination
G7Y69_RS15480	COG0037	tRNA processing
G7Y69_RS15500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G7Y69_RS15505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7Y69_RS15510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7Y69_RS15515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7Y69_RS15520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7Y69_RS15530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7Y69_RS15535	COG0750	zinc metalloprotease
G7Y69_RS15540	COG0575	Belongs to the CDS family
G7Y69_RS15545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G7Y69_RS15550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G7Y69_RS15555	COG0233	cytoplasmic translational termination
G7Y69_RS15560	COG0528	UMP kinase activity
G7Y69_RS15565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G7Y69_RS15580	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G7Y69_RS15595	COG0716	FMN binding
G7Y69_RS15600	COG0564	pseudouridine synthase activity
G7Y69_RS15605	COG3098	single-species biofilm formation
G7Y69_RS15625	COG1611	Belongs to the LOG family
G7Y69_RS15640	COG2363	Small membrane protein
G7Y69_RS15645	COG0583	DNA-binding transcription factor activity
G7Y69_RS15650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G7Y69_RS15655	COG2166	iron-sulfur cluster assembly
G7Y69_RS15660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G7Y69_RS15665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G7Y69_RS15685	COG0860	N-Acetylmuramoyl-L-alanine amidase
G7Y69_RS15690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7Y69_RS15690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G7Y69_RS15700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G7Y69_RS15705	COG1074	ATP-dependent DNA helicase activity
G7Y69_RS15715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G7Y69_RS15745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G7Y69_RS15755	COG0494	nUDIX hydrolase
G7Y69_RS15760	COG4143	(ABC) transporter
G7Y69_RS15765	COG1178	ABC-type Fe3 transport system permease component
G7Y69_RS15770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
G7Y69_RS15775	COG0417	DNA replication proofreading
G7Y69_RS15780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7Y69_RS15785	COG0564	pseudouridine synthase activity
G7Y69_RS15790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G7Y69_RS15795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G7Y69_RS15800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7Y69_RS15805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G7Y69_RS15810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G7Y69_RS15815	COG2967	ApaG domain
G7Y69_RS15820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7Y69_RS15825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G7Y69_RS15830	COG1280	lysine exporter protein (LysE YggA)
G7Y69_RS15835	COG2132	Multicopper oxidase
G7Y69_RS15840	COG0204	Acyl-transferase
G7Y69_RS15850	COG0187	DNA topoisomerase II activity
G7Y69_RS15855	COG3150	esterase
G7Y69_RS15860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G7Y69_RS15865	COG0494	nUDIX hydrolase
G7Y69_RS15875	COG5463	Belongs to the UPF0441 family
G7Y69_RS15880	COG0754	glutathionylspermidine amidase activity
G7Y69_RS15885	COG3384	dioxygenase
G7Y69_RS15890	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G7Y69_RS15905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G7Y69_RS15905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G7Y69_RS15910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G7Y69_RS15915	COG3025	triphosphatase activity
G7Y69_RS15920	COG4991	sh3 domain protein
G7Y69_RS15925	COG0617	tRNA 3'-terminal CCA addition
G7Y69_RS15930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G7Y69_RS15935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G7Y69_RS15940	COG0840	transmembrane signaling receptor activity
G7Y69_RS15945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G7Y69_RS15950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G7Y69_RS15955	COG0358	DNA primase activity
G7Y69_RS15970	COG2814	Major facilitator Superfamily
G7Y69_RS15985	COG2271	Major facilitator Superfamily
G7Y69_RS15995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7Y69_RS16020	COG2226	methyltransferase
G7Y69_RS16070	COG1124	(ABC) transporter
G7Y69_RS16080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7Y69_RS16120	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G7Y69_RS16125	COG0830	nickel cation binding
G7Y69_RS16135	COG0309	Hydrogenase expression formation protein (HypE)
G7Y69_RS16140	COG0409	Hydrogenase expression formation protein
G7Y69_RS16145	COG0298	carbon dioxide binding
G7Y69_RS16150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G7Y69_RS16160	COG1773	rubredoxin
G7Y69_RS16165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G7Y69_RS16170	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G7Y69_RS16175	COG5557	Pfam Polysulphide reductase, NrfD
G7Y69_RS16180	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS16185	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G7Y69_RS16190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G7Y69_RS16200	COG2146	nitrite reductase [NAD(P)H] activity
G7Y69_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS16220	COG1414	Transcriptional regulator
G7Y69_RS16235	COG2271	Major facilitator Superfamily
G7Y69_RS16250	COG1028	Short-chain dehydrogenase reductase Sdr
G7Y69_RS16255	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G7Y69_RS16260	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS16270	COG0590	tRNA wobble adenosine to inosine editing
G7Y69_RS16340	COG3501	Rhs element vgr protein
G7Y69_RS16370	COG1902	pentaerythritol trinitrate reductase activity
G7Y69_RS16370	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7Y69_RS16375	COG1469	GTP cyclohydrolase I activity
G7Y69_RS16385	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
G7Y69_RS16390	COG0861	Integral membrane protein TerC family
G7Y69_RS16395	COG0586	Pfam SNARE associated Golgi protein
G7Y69_RS16400	COG4575	ribosome binding
G7Y69_RS16405	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
G7Y69_RS16415	COG2259	Doxx family
G7Y69_RS16420	COG0583	DNA-binding transcription factor activity
G7Y69_RS16425	COG1741	Belongs to the pirin family
G7Y69_RS16430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS16430	COG3711	transcriptional antiterminator
G7Y69_RS16460	COG3964	amidohydrolase
G7Y69_RS16475	COG0348	domain, Protein
G7Y69_RS16485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G7Y69_RS16495	COG0792	nuclease activity
G7Y69_RS16500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G7Y69_RS16505	COG2823	Periplasmic or secreted lipoprotein
G7Y69_RS16510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7Y69_RS16515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
G7Y69_RS16520	COG5002	protein histidine kinase activity
G7Y69_RS16520	COG2198	Histidine kinase
G7Y69_RS16520	COG0784	Response regulator, receiver
G7Y69_RS16525	COG0493	'glutamate synthase
G7Y69_RS16530	COG2969	positive regulation of protein catabolic process
G7Y69_RS16535	COG0625	glutathione transferase activity
G7Y69_RS16540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G7Y69_RS16545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G7Y69_RS16550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G7Y69_RS16555	COG3105	Protein conserved in bacteria
G7Y69_RS16560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7Y69_RS16565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7Y69_RS16570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7Y69_RS16575	COG5007	Belongs to the BolA IbaG family
G7Y69_RS16585	COG2854	intermembrane phospholipid transfer
G7Y69_RS16590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G7Y69_RS16595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7Y69_RS16600	COG1127	ABC transporter
G7Y69_RS16605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G7Y69_RS16605	COG0517	IMP dehydrogenase activity
G7Y69_RS16610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G7Y69_RS16615	COG3117	lipopolysaccharide transmembrane transporter activity
G7Y69_RS16620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G7Y69_RS16625	COG1137	ATPase activity
G7Y69_RS16630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G7Y69_RS16635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G7Y69_RS16645	COG1660	Displays ATPase and GTPase activities
G7Y69_RS16650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS16655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7Y69_RS16660	COG0312	modulator of DNA gyrase
G7Y69_RS16665	COG3028	Belongs to the UPF0307 family
G7Y69_RS16685	COG2732	(Barnase) inhibitor
G7Y69_RS16695	COG0312	modulator of DNA gyrase
G7Y69_RS16700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7Y69_RS16705	COG3164	Protein of unknown function
G7Y69_RS16710	COG1530	ribonuclease E activity
G7Y69_RS16715	COG0424	maF-like protein
G7Y69_RS16720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G7Y69_RS16725	COG1792	Involved in formation and maintenance of cell shape
G7Y69_RS16730	COG1077	Cell shape determining protein MreB Mrl
G7Y69_RS16735	COG0604	alcohol dehydrogenase
G7Y69_RS16740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G7Y69_RS16745	COG0511	ligase activity, forming carbon-carbon bonds
G7Y69_RS16750	COG0439	Biotin carboxylase
G7Y69_RS16755	COG3924	membrane
G7Y69_RS16760	COG4145	pantothenate transmembrane transporter activity
G7Y69_RS16765	COG2264	protein methyltransferase activity
G7Y69_RS16770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7Y69_RS16775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G7Y69_RS16780	COG0840	transmembrane signaling receptor activity
G7Y69_RS16785	COG4771	TonB-dependent receptor
G7Y69_RS16795	COG0814	amino acid
G7Y69_RS16845	COG2086	electron transfer activity
G7Y69_RS16850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G7Y69_RS16855	COG1960	acyl-CoA dehydrogenase activity
G7Y69_RS16865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G7Y69_RS16885	COG4177	L-phenylalanine transmembrane transporter activity
G7Y69_RS16890	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7Y69_RS16895	COG0683	leucine binding
G7Y69_RS16900	COG0456	acetyltransferase
G7Y69_RS16905	COG0346	lactoylglutathione lyase activity
G7Y69_RS16915	COG2177	Part of the ABC transporter FtsEX involved in
G7Y69_RS16920	COG2884	Cell division ATP-binding protein ftsE
G7Y69_RS16925	COG0552	protein localization to endoplasmic reticulum
G7Y69_RS16925	COG0552	protein localization to endoplasmic reticulum
G7Y69_RS16930	COG0742	ribosomal rna small subunit methyltransferase
G7Y69_RS16935	COG3776	membrane
G7Y69_RS16945	COG3714	YhhN family
G7Y69_RS16955	COG5464	transposase or invertase
G7Y69_RS16965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G7Y69_RS16970	COG0247	lactate metabolic process
G7Y69_RS16980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G7Y69_RS16985	COG2271	Major facilitator Superfamily
G7Y69_RS16990	COG0584	glycerophosphoryl diester phosphodiesterase
G7Y69_RS17000	COG1053	succinate dehydrogenase
G7Y69_RS17005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G7Y69_RS17010	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
G7Y69_RS17015	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
G7Y69_RS17030	COG0477	Major facilitator Superfamily
G7Y69_RS17045	COG0477	Major facilitator Superfamily
G7Y69_RS17055	COG3423	Transcriptional regulator
G7Y69_RS17060	COG2076	Multidrug Resistance protein
G7Y69_RS17070	COG1966	Carbon starvation protein
G7Y69_RS17075	COG2879	small protein
G7Y69_RS17080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7Y69_RS17085	COG1509	lysine 2,3-aminomutase activity
G7Y69_RS17110	COG1027	Aspartate ammonia-lyase
G7Y69_RS17115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G7Y69_RS17125	COG1309	transcriptional regulator
G7Y69_RS17140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G7Y69_RS17145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
G7Y69_RS17155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7Y69_RS17160	COG2731	YhcH YjgK YiaL family protein
G7Y69_RS17165	COG1737	Transcriptional regulator
G7Y69_RS17175	COG0500	methyltransferase
G7Y69_RS17190	COG2197	response regulator
G7Y69_RS17205	COG3188	usher protein
G7Y69_RS17225	COG3188	usher protein
G7Y69_RS17230	COG3121	Chaperone
G7Y69_RS17245	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G7Y69_RS17260	COG2207	Transcriptional regulator
G7Y69_RS17260	COG3708	Transcriptional regulator
G7Y69_RS17270	COG3609	addiction module antidote protein, CC2985 family
G7Y69_RS17275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7Y69_RS17275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7Y69_RS17295	COG4869	propanediol catabolic process
G7Y69_RS17305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G7Y69_RS17310	COG1882	Formate acetyltransferase
G7Y69_RS17325	COG1454	alcohol dehydrogenase
G7Y69_RS17325	COG1012	belongs to the aldehyde dehydrogenase family
G7Y69_RS17350	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS17370	COG1177	transmembrane transport
G7Y69_RS17385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G7Y69_RS17385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G7Y69_RS17400	COG3121	Chaperone
G7Y69_RS17405	COG3188	usher protein
G7Y69_RS17425	COG0583	DNA-binding transcription factor activity
G7Y69_RS17445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G7Y69_RS17450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7Y69_RS17475	COG3239	Fatty acid desaturase
G7Y69_RS17480	COG0726	polysaccharide deacetylase
G7Y69_RS17490	COG2271	Major facilitator Superfamily
G7Y69_RS17505	COG2721	sulfolactate sulfo-lyase activity
G7Y69_RS17520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7Y69_RS17520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7Y69_RS17530	COG3716	PTS system mannose fructose sorbose family IID component
G7Y69_RS17545	COG1349	DNA-binding transcription factor activity
G7Y69_RS17555	COG1129	ABC transporter
G7Y69_RS17560	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7Y69_RS17565	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7Y69_RS17570	COG3623	hexulose-6-phosphate isomerase
G7Y69_RS17575	COG1070	Carbohydrate kinase
G7Y69_RS17580	COG2194	sulfuric ester hydrolase activity
G7Y69_RS17590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS17595	COG2814	Major facilitator Superfamily
G7Y69_RS17600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7Y69_RS17610	COG1609	Transcriptional regulator
G7Y69_RS17615	COG0583	DNA-binding transcription factor activity
G7Y69_RS17620	COG2610	gluconate transmembrane transporter activity
G7Y69_RS17625	COG3048	D-serine ammonia-lyase activity
G7Y69_RS17630	COG1363	Peptidase, m42
G7Y69_RS17635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7Y69_RS17645	COG0444	Belongs to the ABC transporter superfamily
G7Y69_RS17655	COG0747	negative chemotaxis
G7Y69_RS17665	COG3573	Dehydrogenase
G7Y69_RS17685	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y69_RS17690	COG0625	glutathione transferase activity
G7Y69_RS17700	COG1840	ABC-type Fe3 transport system, periplasmic component
G7Y69_RS17705	COG3842	ATPase activity
G7Y69_RS17710	COG0204	Acyl-transferase
G7Y69_RS17710	COG0318	PFAM AMP-dependent synthetase and ligase
G7Y69_RS17715	COG1858	cytochrome C peroxidase
G7Y69_RS17720	COG2211	Major facilitator Superfamily
G7Y69_RS17725	COG1397	ADP-ribosylglycohydrolase
G7Y69_RS17730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7Y69_RS17735	COG2188	Transcriptional regulator
G7Y69_RS17745	COG3302	dmso reductase anchor subunit
G7Y69_RS17750	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS17755	COG0243	molybdopterin cofactor binding
G7Y69_RS17775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7Y69_RS17780	COG1538	Outer membrane efflux protein
G7Y69_RS17785	COG0577	efflux transmembrane transporter activity
G7Y69_RS17785	COG1136	(ABC) transporter
G7Y69_RS17790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7Y69_RS17795	COG1132	(ABC) transporter
G7Y69_RS17825	COG3539	Fimbrial protein
G7Y69_RS17835	COG3121	Chaperone
G7Y69_RS17840	COG3188	usher protein
G7Y69_RS17850	COG3539	Fimbrial protein
G7Y69_RS17870	COG2205	protein histidine kinase activity
G7Y69_RS17875	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS17880	COG0582	viral genome integration into host DNA
G7Y69_RS17890	COG1396	sequence-specific DNA binding
G7Y69_RS17905	COG3188	usher protein
G7Y69_RS17910	COG3121	Chaperone
G7Y69_RS17955	COG3069	C4-dicarboxylate transmembrane transporter activity
G7Y69_RS17960	COG1473	amidohydrolase
G7Y69_RS17980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G7Y69_RS17990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7Y69_RS18005	COG1070	Carbohydrate kinase
G7Y69_RS18010	COG4806	L-rhamnose isomerase
G7Y69_RS18025	COG1454	alcohol dehydrogenase
G7Y69_RS18030	COG3254	rhamnose metabolic process
G7Y69_RS18035	COG4977	sequence-specific DNA binding
G7Y69_RS18035	COG1917	Cupin 2, conserved barrel domain protein
G7Y69_RS18040	COG4977	sequence-specific DNA binding
G7Y69_RS18050	COG3121	Chaperone
G7Y69_RS18055	COG3188	usher protein
G7Y69_RS18065	COG3069	C4-dicarboxylate transmembrane transporter activity
G7Y69_RS18085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7Y69_RS18090	COG0583	DNA-binding transcription factor activity
G7Y69_RS18140	COG3157	Type VI secretion system effector, Hcp
G7Y69_RS18160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G7Y69_RS18175	COG0795	lipopolysaccharide-transporting ATPase activity
G7Y69_RS18180	COG0795	lipopolysaccharide-transporting ATPase activity
G7Y69_RS18185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G7Y69_RS18190	COG2927	DNA polymerase III (CHI subunit)
G7Y69_RS18195	COG0525	valine-tRNA ligase activity
G7Y69_RS18210	COG1285	pathogenesis
G7Y69_RS18215	COG2211	Major facilitator Superfamily
G7Y69_RS18225	COG1609	Transcriptional regulator
G7Y69_RS18230	COG1085	galactose-1-phosphate uridylyltransferase
G7Y69_RS18250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G7Y69_RS18265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7Y69_RS18275	COG2188	Transcriptional regulator
G7Y69_RS18305	COG0540	Belongs to the ATCase OTCase family
G7Y69_RS18310	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
G7Y69_RS18315	COG0251	oxidation-reduction process
G7Y69_RS18320	COG1328	CTP reductase activity
G7Y69_RS18325	COG0602	queuosine metabolic process
G7Y69_RS18330	COG3787	Belongs to the UPF0306 family
G7Y69_RS18340	COG2827	Endonuclease containing a URI domain
G7Y69_RS18345	COG3153	acetyltransferase
G7Y69_RS18350	COG3154	lipid carrier protein
G7Y69_RS18355	COG0826	peptidase U32
G7Y69_RS18360	COG0826	peptidase U32
G7Y69_RS18370	COG3077	Addiction module antitoxin, RelB DinJ family
G7Y69_RS18390	COG3275	phosphorelay sensor kinase activity
G7Y69_RS18410	COG0513	Belongs to the DEAD box helicase family
G7Y69_RS18430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G7Y69_RS18435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G7Y69_RS18440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G7Y69_RS18445	COG0195	Participates in both transcription termination and antitermination
G7Y69_RS18450	COG0779	Required for maturation of 30S ribosomal subunits
G7Y69_RS18465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G7Y69_RS18470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7Y69_RS18475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G7Y69_RS18480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7Y69_RS18485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G7Y69_RS18490	COG1534	Rna-binding protein
G7Y69_RS18500	COG2027	D-alanyl-D-alanine carboxypeptidase
G7Y69_RS18505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G7Y69_RS18510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G7Y69_RS18515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G7Y69_RS18520	COG0142	geranyltranstransferase activity
G7Y69_RS18535	COG3423	Transcriptional regulator
G7Y69_RS18540	COG0039	L-malate dehydrogenase activity
G7Y69_RS18545	COG1438	arginine binding
G7Y69_RS18555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7Y69_RS18560	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G7Y69_RS18570	COG2105	PFAM AIG2 family protein
G7Y69_RS18575	COG2911	Protein conserved in bacteria
G7Y69_RS18580	COG0729	surface antigen
G7Y69_RS18585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7Y69_RS18590	COG1253	flavin adenine dinucleotide binding
G7Y69_RS18600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
G7Y69_RS18605	COG0642	Histidine kinase
G7Y69_RS18615	COG3111	PFAM Bacterial OB fold (BOF) protein
G7Y69_RS18620	COG0494	nUDIX hydrolase
G7Y69_RS18630	COG0579	oxidoreductase
G7Y69_RS18640	COG0545	Peptidyl-prolyl cis-trans isomerase
G7Y69_RS18645	COG3061	Opacity-associated protein A
G7Y69_RS18655	COG0359	binds to the 23S rRNA
G7Y69_RS18660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G7Y69_RS18665	COG2965	DNA replication, synthesis of RNA primer
G7Y69_RS18670	COG0360	Binds together with S18 to 16S ribosomal RNA
G7Y69_RS18675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7Y69_RS18680	COG0557	exoribonuclease II activity
G7Y69_RS18685	COG1959	2 iron, 2 sulfur cluster binding
G7Y69_RS18690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G7Y69_RS18695	COG0330	HflC and HflK could
G7Y69_RS18700	COG0330	HflC and HflK could
G7Y69_RS18705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G7Y69_RS18710	COG1923	regulation of RNA biosynthetic process
G7Y69_RS18715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G7Y69_RS18720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G7Y69_RS18730	COG0802	atpase or kinase
G7Y69_RS18735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G7Y69_RS18760	COG1162	GTPase activity
G7Y69_RS18765	COG0688	phosphatidylethanolamine metabolic process
G7Y69_RS18770	COG3264	Mechanosensitive ion channel
G7Y69_RS18770	COG1511	domain protein
G7Y69_RS18785	COG0561	phosphatase activity
G7Y69_RS18790	COG2267	carboxylic ester hydrolase activity
G7Y69_RS18805	COG2050	protein possibly involved in aromatic compounds catabolism
G7Y69_RS18815	COG0531	amino acid
G7Y69_RS18830	COG1690	Belongs to the RtcB family
G7Y69_RS18835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G7Y69_RS18855	COG0210	DNA helicase
G7Y69_RS18860	COG1011	Hydrolase
G7Y69_RS18875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G7Y69_RS18880	COG5567	small periplasmic lipoprotein
G7Y69_RS18885	COG1965	Belongs to the frataxin family
G7Y69_RS18905	COG2959	enzyme of heme biosynthesis
G7Y69_RS18910	COG3071	HemY protein
G7Y69_RS18945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
G7Y69_RS18955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7Y69_RS18960	COG2244	polysaccharide biosynthetic process
G7Y69_RS18965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G7Y69_RS18975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G7Y69_RS18980	COG1088	dTDP-glucose 4,6-dehydratase activity
G7Y69_RS18985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G7Y69_RS18990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G7Y69_RS18995	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G7Y69_RS19000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7Y69_RS19005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G7Y69_RS19010	COG3118	belongs to the thioredoxin family
G7Y69_RS19015	COG0513	Belongs to the DEAD box helicase family
G7Y69_RS19025	COG0210	DNA helicase
G7Y69_RS19030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G7Y69_RS19045	COG0129	dihydroxy-acid dehydratase activity
G7Y69_RS19055	COG3978	acetolactate synthase activity
G7Y69_RS19070	COG0606	chelatase, subunit chli
G7Y69_RS19075	COG3085	chromosome segregation
G7Y69_RS19080	COG0583	DNA-binding transcription factor activity
G7Y69_RS19115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G7Y69_RS19120	COG4206	TonB-dependent receptor
G7Y69_RS19125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7Y69_RS19140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7Y69_RS19160	COG0165	Argininosuccinate lyase
G7Y69_RS19165	COG0137	argininosuccinate synthase activity
G7Y69_RS19170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7Y69_RS19175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G7Y69_RS19180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7Y69_RS19185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G7Y69_RS19190	COG0076	glutamate decarboxylase activity
G7Y69_RS19195	COG0531	amino acid
G7Y69_RS19200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G7Y69_RS19210	COG0460	homoserine dehydrogenase
G7Y69_RS19210	COG0527	aspartate kinase activity
G7Y69_RS19215	COG0626	cystathionine gamma-synthase activity
G7Y69_RS19230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G7Y69_RS19235	COG1609	Transcriptional regulator
G7Y69_RS19240	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G7Y69_RS19245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G7Y69_RS19250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G7Y69_RS19255	COG1575	Belongs to the MenA family. Type 1 subfamily
G7Y69_RS19260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7Y69_RS19265	COG3074	FtsZ-dependent cytokinesis
G7Y69_RS19275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7Y69_RS19285	COG2814	Major facilitator Superfamily
G7Y69_RS19295	COG3152	Membrane
G7Y69_RS19305	COG0149	triose-phosphate isomerase activity
G7Y69_RS19315	COG1472	Belongs to the glycosyl hydrolase 3 family
G7Y69_RS19330	COG0205	6-phosphofructokinase activity
G7Y69_RS19335	COG4589	Belongs to the CDS family
G7Y69_RS19345	COG0501	Belongs to the peptidase M48B family
G7Y69_RS19355	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G7Y69_RS19365	COG3678	ATP-independent chaperone mediated protein folding
G7Y69_RS19370	COG0745	RESPONSE REGULATOR receiver
G7Y69_RS19375	COG2205	protein histidine kinase activity
G7Y69_RS19390	COG1442	glycosyl transferase family 8
G7Y69_RS19390	COG1216	Glycosyl transferase, family 2
G7Y69_RS19400	COG0297	glycogen (starch) synthase activity
G7Y69_RS19400	COG0438	transferase activity, transferring glycosyl groups
G7Y69_RS19420	COG1215	transferase activity, transferring glycosyl groups
G7Y69_RS19425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7Y69_RS19430	COG1596	polysaccharide export
G7Y69_RS19435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G7Y69_RS19440	COG3206	protein involved in exopolysaccharide biosynthesis
G7Y69_RS19440	COG0489	protein tyrosine kinase activity
G7Y69_RS19445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G7Y69_RS19450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G7Y69_RS19455	COG2337	Toxic component of a toxin-antitoxin (TA) module
G7Y69_RS19465	COG1045	serine acetyltransferase
G7Y69_RS19470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7Y69_RS19480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7Y69_RS19485	COG4942	peptidase
G7Y69_RS19490	COG2861	carbohydrate metabolic process
G7Y69_RS19495	COG1063	alcohol dehydrogenase
G7Y69_RS19500	COG0156	8-amino-7-oxononanoate synthase activity
G7Y69_RS19505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7Y69_RS19515	COG0859	PFAM glycosyl transferase family 9
G7Y69_RS19530	COG1519	Transferase
G7Y69_RS19535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G7Y69_RS19540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7Y69_RS19565	COG0515	serine threonine protein kinase
G7Y69_RS19570	COG0438	transferase activity, transferring glycosyl groups
G7Y69_RS19575	COG0859	PFAM glycosyl transferase family 9
G7Y69_RS19585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G7Y69_RS19595	COG2003	Belongs to the UPF0758 family
G7Y69_RS19600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G7Y69_RS19605	COG0756	dUTP diphosphatase activity
G7Y69_RS19610	COG1309	transcriptional regulator
G7Y69_RS19615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G7Y69_RS19620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G7Y69_RS19625	COG1561	YicC-like family, N-terminal region
G7Y69_RS19630	COG2271	Major facilitator Superfamily
G7Y69_RS19635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7Y69_RS19635	COG0473	3-isopropylmalate dehydrogenase activity
G7Y69_RS19640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7Y69_RS19650	COG2211	Major facilitator Superfamily
G7Y69_RS19665	COG1940	carbohydrate kinase activity
G7Y69_RS19665	COG1846	Transcriptional regulator
G7Y69_RS19675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G7Y69_RS19690	COG1368	sulfuric ester hydrolase activity
G7Y69_RS19695	COG3276	selenocysteine insertion sequence binding
G7Y69_RS19700	COG1921	L-seryl-tRNASec selenium transferase activity
G7Y69_RS19705	COG3058	Necessary for formate dehydrogenase activity
G7Y69_RS19725	COG1312	Catalyzes the dehydration of D-mannonate
G7Y69_RS19730	COG2186	Transcriptional regulator
G7Y69_RS19735	COG4948	Mandelate Racemase Muconate Lactonizing
G7Y69_RS19740	COG1063	alcohol dehydrogenase
G7Y69_RS19745	COG0477	Major facilitator Superfamily
G7Y69_RS19750	COG0246	Mannitol dehydrogenase
G7Y69_RS19765	COG0679	Auxin Efflux Carrier
G7Y69_RS19770	COG0028	Belongs to the TPP enzyme family
G7Y69_RS19780	COG2864	formate dehydrogenase
G7Y69_RS19785	COG0437	4 iron, 4 sulfur cluster binding
G7Y69_RS19795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7Y69_RS19800	COG3550	peptidyl-serine autophosphorylation
G7Y69_RS19810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G7Y69_RS19815	COG0706	membrane insertase activity
G7Y69_RS19820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G7Y69_RS19825	COG0594	ribonuclease P activity
G7Y69_RS19830	COG0230	Belongs to the bacterial ribosomal protein bL34 family