locus-tag	class	description
H0904_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0904_RS00010	COG0592	DNA-directed DNA polymerase activity
H0904_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0904_RS00020	COG0187	DNA topoisomerase II activity
H0904_RS00030	COG2194	sulfuric ester hydrolase activity
H0904_RS00040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0904_RS00045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0904_RS00050	COG0254	rRNA binding
H0904_RS00060	COG1940	carbohydrate kinase activity
H0904_RS00120	COG4264	IucA IucC family
H0904_RS00125	COG4774	siderophore transport
H0904_RS00130	COG0019	diaminopimelate decarboxylase activity
H0904_RS00135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0904_RS00140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0904_RS00145	COG2814	Major facilitator Superfamily
H0904_RS00160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0904_RS00165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0904_RS00170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0904_RS00175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0904_RS00180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0904_RS00185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0904_RS00190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0904_RS00205	COG0356	it plays a direct role in the translocation of protons across the membrane
H0904_RS00210	COG3312	ion transport
H0904_RS00215	COG0357	Ribosomal RNA small subunit methyltransferase G
H0904_RS00220	COG0445	tRNA wobble uridine modification
H0904_RS00225	COG0716	FMN binding
H0904_RS00230	COG1522	sequence-specific DNA binding
H0904_RS00235	COG2502	aspartate--ammonia ligase
H0904_RS00240	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H0904_RS00245	COG0714	Associated with various cellular activities
H0904_RS00255	COG1129	ABC transporter
H0904_RS00260	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0904_RS00270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS00275	COG1609	Transcriptional regulator
H0904_RS00280	COG0477	Major facilitator Superfamily
H0904_RS00285	COG2186	Transcriptional regulator
H0904_RS00320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H0904_RS00335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0904_RS00340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0904_RS00345	COG3162	membrane
H0904_RS00350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0904_RS00355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0904_RS00360	COG0443	Heat shock 70 kDa protein
H0904_RS00370	COG2258	MOSC domain
H0904_RS00380	COG1132	(ABC) transporter
H0904_RS00395	COG1335	isochorismatase
H0904_RS00400	COG2353	YceI-like domain
H0904_RS00405	COG1304	FMN binding
H0904_RS00410	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS00415	COG0180	Tryptophanyl-tRNA synthetase
H0904_RS00420	COG0546	phosphoglycolate phosphatase activity
H0904_RS00425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0904_RS00440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0904_RS00445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0904_RS00450	COG4796	Type ii and iii secretion system protein
H0904_RS00470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0904_RS00475	COG0494	nUDIX hydrolase
H0904_RS00485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0904_RS00490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0904_RS00495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0904_RS00500	COG1741	Belongs to the pirin family
H0904_RS00505	COG2081	HI0933 family
H0904_RS00510	COG0306	phosphate transporter
H0904_RS00520	COG0589	response to stress
H0904_RS00525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0904_RS00530	COG0742	ribosomal rna small subunit methyltransferase
H0904_RS00575	COG3122	Protein conserved in bacteria
H0904_RS00585	COG1278	Cold shock
H0904_RS00590	COG1737	Transcriptional regulator
H0904_RS00610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0904_RS00725	COG1940	carbohydrate kinase activity
H0904_RS00725	COG1846	Transcriptional regulator
H0904_RS00740	COG2211	Major facilitator Superfamily
H0904_RS00745	COG1561	YicC-like family, N-terminal region
H0904_RS00750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0904_RS00755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0904_RS00760	COG1309	transcriptional regulator
H0904_RS00765	COG0756	dUTP diphosphatase activity
H0904_RS00770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0904_RS00775	COG2003	Belongs to the UPF0758 family
H0904_RS00780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0904_RS00790	COG0859	PFAM glycosyl transferase family 9
H0904_RS00795	COG3307	-O-antigen
H0904_RS00800	COG1216	Glycosyl transferase, family 2
H0904_RS00805	COG0438	transferase activity, transferring glycosyl groups
H0904_RS00810	COG0515	serine threonine protein kinase
H0904_RS00820	COG1442	glycosyl transferase family 8
H0904_RS00825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H0904_RS00830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0904_RS00835	COG1519	Transferase
H0904_RS00855	COG0859	PFAM glycosyl transferase family 9
H0904_RS00860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0904_RS00865	COG0156	8-amino-7-oxononanoate synthase activity
H0904_RS00870	COG1063	alcohol dehydrogenase
H0904_RS00875	COG2861	carbohydrate metabolic process
H0904_RS00880	COG4942	peptidase
H0904_RS00885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0904_RS00895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0904_RS00900	COG1045	serine acetyltransferase
H0904_RS00910	COG2337	Toxic component of a toxin-antitoxin (TA) module
H0904_RS00915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0904_RS00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0904_RS00925	COG0489	protein tyrosine kinase activity
H0904_RS00925	COG3206	protein involved in exopolysaccharide biosynthesis
H0904_RS00930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0904_RS00935	COG1596	polysaccharide export
H0904_RS00950	COG1216	Glycosyl transferase, family 2
H0904_RS00960	COG1051	belongs to the nudix hydrolase family
H0904_RS00965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0904_RS00975	COG0110	maltose O-acetyltransferase activity
H0904_RS00985	COG0438	transferase activity, transferring glycosyl groups
H0904_RS01010	COG2205	protein histidine kinase activity
H0904_RS01015	COG0745	RESPONSE REGULATOR receiver
H0904_RS01020	COG3678	ATP-independent chaperone mediated protein folding
H0904_RS01025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0904_RS01075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0904_RS01080	COG4695	Portal protein
H0904_RS01220	COG3657	addiction module killer protein
H0904_RS01225	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0904_RS01235	COG0501	Belongs to the peptidase M48B family
H0904_RS01245	COG4589	Belongs to the CDS family
H0904_RS01250	COG0205	6-phosphofructokinase activity
H0904_RS01265	COG1472	Belongs to the glycosyl hydrolase 3 family
H0904_RS01275	COG0149	triose-phosphate isomerase activity
H0904_RS01285	COG3152	Membrane
H0904_RS01290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0904_RS01295	COG2814	Major facilitator Superfamily
H0904_RS01305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0904_RS01315	COG3074	FtsZ-dependent cytokinesis
H0904_RS01320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0904_RS01325	COG1575	Belongs to the MenA family. Type 1 subfamily
H0904_RS01330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H0904_RS01335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H0904_RS01340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0904_RS01345	COG1609	Transcriptional regulator
H0904_RS01350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0904_RS01365	COG0626	cystathionine gamma-synthase activity
H0904_RS01370	COG0527	aspartate kinase activity
H0904_RS01370	COG0460	homoserine dehydrogenase
H0904_RS01375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H0904_RS01380	COG0531	amino acid
H0904_RS01385	COG0076	glutamate decarboxylase activity
H0904_RS01390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0904_RS01395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0904_RS01400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H0904_RS01405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0904_RS01410	COG0137	argininosuccinate synthase activity
H0904_RS01415	COG0165	Argininosuccinate lyase
H0904_RS01435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0904_RS01450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0904_RS01460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0904_RS01485	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H0904_RS01490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0904_RS01515	COG0800	Aldolase
H0904_RS01520	COG0129	dihydroxy-acid dehydratase activity
H0904_RS01535	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0904_RS01540	COG1414	Transcriptional regulator
H0904_RS01545	COG0646	methionine synthase
H0904_RS01545	COG1410	methionine synthase
H0904_RS01560	COG0527	aspartate kinase activity
H0904_RS01565	COG0166	Belongs to the GPI family
H0904_RS01570	COG3161	chorismate lyase activity
H0904_RS01580	COG2937	Belongs to the GPAT DAPAT family
H0904_RS01585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H0904_RS01595	COG0735	belongs to the Fur family
H0904_RS01635	COG3121	Chaperone
H0904_RS01640	COG1446	asparaginase
H0904_RS01660	COG0157	Belongs to the NadC ModD family
H0904_RS01665	COG0500	methyltransferase
H0904_RS01670	COG1120	ATPase activity
H0904_RS01685	COG1609	Transcriptional regulator
H0904_RS01690	COG3265	gluconokinase activity
H0904_RS01695	COG2610	gluconate transmembrane transporter activity
H0904_RS01755	COG2992	FlgJ-related protein
H0904_RS01795	COG2137	regulation of response to DNA damage stimulus
H0904_RS01805	COG3069	C4-dicarboxylate transmembrane transporter activity
H0904_RS01810	COG0814	amino acid
H0904_RS01815	COG2873	o-acetylhomoserine
H0904_RS01820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0904_RS01830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0904_RS01835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0904_RS01845	COG0789	Transcriptional regulator
H0904_RS01860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0904_RS01865	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H0904_RS01910	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0904_RS01930	COG0025	NhaP-type Na H and K H
H0904_RS01995	COG0243	molybdopterin cofactor binding
H0904_RS02000	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS02010	COG3381	protein complex oligomerization
H0904_RS02020	COG3541	Predicted nucleotidyltransferase
H0904_RS02025	COG1690	Belongs to the RtcB family
H0904_RS02035	COG4650	regulator
H0904_RS02040	COG1470	cell adhesion involved in biofilm formation
H0904_RS02040	COG1388	LysM domain
H0904_RS02055	COG1349	DNA-binding transcription factor activity
H0904_RS02060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0904_RS02070	COG0738	Major facilitator superfamily
H0904_RS02085	COG0668	transmembrane transport
H0904_RS02090	COG1982	Orn Lys Arg decarboxylase major
H0904_RS02095	COG1957	nucleoside hydrolase
H0904_RS02105	COG0483	inositol monophosphate 1-phosphatase activity
H0904_RS02110	COG3196	Protein conserved in bacteria
H0904_RS02120	COG1335	isochorismatase
H0904_RS02125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0904_RS02140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0904_RS02150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0904_RS02165	COG2814	Major facilitator Superfamily
H0904_RS02175	COG0028	Belongs to the TPP enzyme family
H0904_RS02180	COG0440	acetolactate synthase activity
H0904_RS02185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0904_RS02210	COG2252	PERMEase
H0904_RS02215	COG0025	NhaP-type Na H and K H
H0904_RS02225	COG0583	DNA-binding transcription factor activity
H0904_RS02230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0904_RS02235	COG3753	Protein conserved in bacteria
H0904_RS02240	COG2084	Dehydrogenase
H0904_RS02245	COG3395	kinase activity
H0904_RS02250	COG0235	Class ii aldolase
H0904_RS02255	COG3622	Belongs to the hyi family
H0904_RS02260	COG1349	DNA-binding transcription factor activity
H0904_RS02265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0904_RS02270	COG2610	gluconate transmembrane transporter activity
H0904_RS02275	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H0904_RS02285	COG0586	Pfam SNARE associated Golgi protein
H0904_RS02295	COG2226	methyltransferase
H0904_RS02300	COG3165	ubiquinone biosynthetic process from chorismate
H0904_RS02310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0904_RS02315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0904_RS02320	COG0805	protein transport
H0904_RS02335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H0904_RS02345	COG0183	Belongs to the thiolase family
H0904_RS02350	COG1024	Enoyl-CoA hydratase
H0904_RS02350	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0904_RS02355	COG0006	proline dipeptidase activity
H0904_RS02360	COG1739	Uncharacterized protein family UPF0029
H0904_RS02365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0904_RS02395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0904_RS02400	COG2197	response regulator
H0904_RS02405	COG3850	Histidine kinase
H0904_RS02410	COG2354	Protein conserved in bacteria
H0904_RS02415	COG1216	Glycosyl transferase, family 2
H0904_RS02430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0904_RS02440	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS02450	COG0531	amino acid
H0904_RS02465	COG1785	Belongs to the alkaline phosphatase family
H0904_RS02490	COG2813	Specifically methylates the guanine in position
H0904_RS02505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0904_RS02515	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS02530	COG0583	DNA-binding transcription factor activity
H0904_RS02535	COG0473	3-isopropylmalate dehydrogenase activity
H0904_RS02700	COG3173	Aminoglycoside phosphotransferase
H0904_RS02720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0904_RS02770	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0904_RS02845	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
H0904_RS02895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0904_RS02910	COG0681	Belongs to the peptidase S26 family
H0904_RS02950	COG0629	single-stranded DNA binding
H0904_RS02970	COG0714	Associated with various cellular activities
H0904_RS02995	COG2003	Belongs to the UPF0758 family
H0904_RS03095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0904_RS03105	COG4667	esterase of the alpha-beta hydrolase superfamily
H0904_RS03110	COG0084	hydrolase, TatD family'
H0904_RS03115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H0904_RS03125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H0904_RS03130	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H0904_RS03135	COG0813	purine-nucleoside phosphorylase activity
H0904_RS03150	COG1247	-acetyltransferase
H0904_RS03170	COG0612	Peptidase, M16
H0904_RS03175	COG4178	(ABC) transporter
H0904_RS03180	COG4771	TonB-dependent receptor
H0904_RS03190	COG1595	DNA-templated transcription, initiation
H0904_RS03200	COG3726	membrane protein affecting hemolysin expression
H0904_RS03205	COG0560	Phosphoserine phosphatase
H0904_RS03210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0904_RS03220	COG0488	(ABC) transporter
H0904_RS03235	COG0741	lytic transglycosylase activity
H0904_RS03240	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H0904_RS03245	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H0904_RS03250	COG0406	alpha-ribazole phosphatase activity
H0904_RS03255	COG3708	Transcriptional regulator
H0904_RS03255	COG2207	Transcriptional regulator
H0904_RS03260	COG3045	CreA protein
H0904_RS03265	COG0745	RESPONSE REGULATOR receiver
H0904_RS03280	COG0083	homoserine kinase activity
H0904_RS03310	COG5002	protein histidine kinase activity
H0904_RS03315	COG0745	RESPONSE REGULATOR receiver
H0904_RS03345	COG0667	Aldo Keto reductase
H0904_RS03350	COG3022	response to hydroperoxide
H0904_RS03355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0904_RS03360	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0904_RS03365	COG1584	GPR1 FUN34 yaaH family protein
H0904_RS03370	COG0443	Heat shock 70 kDa protein
H0904_RS03375	COG0484	heat shock protein binding
H0904_RS03380	COG0402	S-adenosylhomocysteine deaminase activity
H0904_RS03390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0904_RS03395	COG0583	DNA-binding transcription factor activity
H0904_RS03400	COG0268	Binds directly to 16S ribosomal RNA
H0904_RS03405	COG0196	riboflavin kinase activity
H0904_RS03410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0904_RS03415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0904_RS03420	COG1047	Peptidyl-prolyl cis-trans
H0904_RS03425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H0904_RS03430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0904_RS03435	COG0505	Belongs to the CarA family
H0904_RS03445	COG0789	Transcriptional regulator
H0904_RS03455	COG0626	cystathionine gamma-synthase activity
H0904_RS03465	COG0848	biopolymer transport protein
H0904_RS03470	COG2391	methyltransferase activity
H0904_RS03475	COG0425	Belongs to the sulfur carrier protein TusA family
H0904_RS03485	COG2974	May be involved in recombination
H0904_RS03490	COG1940	carbohydrate kinase activity
H0904_RS03495	COG0737	Belongs to the 5'-nucleotidase family
H0904_RS03525	COG0419	ATPase involved in DNA repair
H0904_RS03530	COG0420	3'-5' exonuclease activity
H0904_RS03535	COG0745	RESPONSE REGULATOR receiver
H0904_RS03540	COG5002	protein histidine kinase activity
H0904_RS03565	COG0450	alkyl hydroperoxide reductase
H0904_RS03570	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H0904_RS03575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0904_RS03585	COG1862	Preprotein translocase
H0904_RS03590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0904_RS03595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0904_RS03600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0904_RS03605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0904_RS03605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0904_RS03610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0904_RS03615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0904_RS03620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0904_RS03625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0904_RS03630	COG2271	Major facilitator Superfamily
H0904_RS03660	COG1960	acyl-CoA dehydrogenase activity
H0904_RS03665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0904_RS03670	COG0318	PFAM AMP-dependent synthetase and ligase
H0904_RS03675	COG1024	Enoyl-CoA hydratase
H0904_RS03690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0904_RS03695	COG0142	geranyltranstransferase activity
H0904_RS03705	COG0301	tRNA thio-modification
H0904_RS03705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0904_RS03720	COG0693	protein deglycase activity
H0904_RS03725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H0904_RS03730	COG1666	GTP binding
H0904_RS03735	COG2814	Major facilitator Superfamily
H0904_RS03740	COG0109	protoheme IX farnesyltransferase activity
H0904_RS03745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0904_RS03750	COG1845	cytochrome c oxidase, subunit III
H0904_RS03755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0904_RS03760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0904_RS03770	COG2223	nitrite transmembrane transporter activity
H0904_RS03775	COG3056	Lipoprotein
H0904_RS03780	COG0271	Belongs to the BolA IbaG family
H0904_RS03785	COG0544	peptidyl-prolyl cis-trans isomerase activity
H0904_RS03790	COG0740	serine-type endopeptidase activity
H0904_RS03795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0904_RS03800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0904_RS03805	COG0776	regulation of translation
H0904_RS03810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0904_RS03815	COG1555	photosystem II stabilization
H0904_RS03820	COG0824	Thioesterase
H0904_RS03830	COG1522	sequence-specific DNA binding
H0904_RS03835	COG1132	(ABC) transporter
H0904_RS03840	COG1132	(ABC) transporter
H0904_RS03845	COG0347	Belongs to the P(II) protein family
H0904_RS03850	COG0004	ammonium transporteR
H0904_RS03855	COG1946	Acyl-CoA thioesterase
H0904_RS03860	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H0904_RS03880	COG0741	lytic transglycosylase activity
H0904_RS03880	COG1388	LysM domain
H0904_RS03885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0904_RS03890	COG2226	methyltransferase
H0904_RS03895	COG0328	RNA-DNA hybrid ribonuclease activity
H0904_RS03910	COG1396	sequence-specific DNA binding
H0904_RS03935	COG3188	usher protein
H0904_RS03955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0904_RS03960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0904_RS03965	COG0126	phosphoglycerate kinase activity
H0904_RS04000	COG0590	tRNA wobble adenosine to inosine editing
H0904_RS04050	COG1704	LemA family
H0904_RS04055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0904_RS04060	COG2368	4-hydroxyphenylacetate
H0904_RS04080	COG3971	2-oxopent-4-enoate hydratase activity
H0904_RS04090	COG2814	Major facilitator Superfamily
H0904_RS04100	COG3384	dioxygenase
H0904_RS04105	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS04115	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0904_RS04120	COG1846	Transcriptional regulator
H0904_RS04125	COG2831	hemolysin activation secretion protein
H0904_RS04130	COG3210	domain, Protein
H0904_RS04190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0904_RS04195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0904_RS04215	COG2194	sulfuric ester hydrolase activity
H0904_RS04220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0904_RS04230	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0904_RS04240	COG3118	belongs to the thioredoxin family
H0904_RS04250	COG1609	Transcriptional regulator
H0904_RS04255	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0904_RS04260	COG1129	ABC transporter
H0904_RS04265	COG1879	ABC-type sugar transport system periplasmic component
H0904_RS04270	COG1063	alcohol dehydrogenase
H0904_RS04275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0904_RS04285	COG0583	DNA-binding transcription factor activity
H0904_RS04290	COG1285	pathogenesis
H0904_RS04295	COG2211	Major facilitator Superfamily
H0904_RS04315	COG1309	transcriptional regulator
H0904_RS04325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0904_RS04330	COG1027	Aspartate ammonia-lyase
H0904_RS04355	COG1509	lysine 2,3-aminomutase activity
H0904_RS04360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0904_RS04365	COG2879	small protein
H0904_RS04370	COG1966	Carbon starvation protein
H0904_RS04380	COG2076	Multidrug Resistance protein
H0904_RS04385	COG3423	Transcriptional regulator
H0904_RS04395	COG0477	Major facilitator Superfamily
H0904_RS04405	COG0477	Major facilitator Superfamily
H0904_RS04420	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H0904_RS04425	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H0904_RS04430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0904_RS04435	COG1053	succinate dehydrogenase
H0904_RS04445	COG0584	glycerophosphoryl diester phosphodiesterase
H0904_RS04455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0904_RS04465	COG0247	lactate metabolic process
H0904_RS04470	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H0904_RS04480	COG5464	transposase or invertase
H0904_RS04485	COG2217	Heavy metal translocating P-type atpase
H0904_RS04490	COG3714	YhhN family
H0904_RS04500	COG3776	membrane
H0904_RS04505	COG0742	ribosomal rna small subunit methyltransferase
H0904_RS04510	COG0552	protein localization to endoplasmic reticulum
H0904_RS04510	COG0552	protein localization to endoplasmic reticulum
H0904_RS04515	COG2884	Cell division ATP-binding protein ftsE
H0904_RS04520	COG2177	Part of the ABC transporter FtsEX involved in
H0904_RS04530	COG0346	lactoylglutathione lyase activity
H0904_RS04535	COG0456	acetyltransferase
H0904_RS04540	COG0683	leucine binding
H0904_RS04545	COG0559	Belongs to the binding-protein-dependent transport system permease family
H0904_RS04550	COG4177	L-phenylalanine transmembrane transporter activity
H0904_RS04570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H0904_RS04580	COG1960	acyl-CoA dehydrogenase activity
H0904_RS04585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0904_RS04590	COG2086	electron transfer activity
H0904_RS04640	COG0814	amino acid
H0904_RS04650	COG4771	TonB-dependent receptor
H0904_RS04655	COG0840	transmembrane signaling receptor activity
H0904_RS04660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0904_RS04665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0904_RS04670	COG2264	protein methyltransferase activity
H0904_RS04675	COG4145	pantothenate transmembrane transporter activity
H0904_RS04680	COG3924	membrane
H0904_RS04685	COG0439	Biotin carboxylase
H0904_RS04690	COG0511	ligase activity, forming carbon-carbon bonds
H0904_RS04695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0904_RS04700	COG0604	alcohol dehydrogenase
H0904_RS04705	COG1077	Cell shape determining protein MreB Mrl
H0904_RS04710	COG1792	Involved in formation and maintenance of cell shape
H0904_RS04715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0904_RS04720	COG0424	maF-like protein
H0904_RS04725	COG1530	ribonuclease E activity
H0904_RS04730	COG3164	Protein of unknown function
H0904_RS04735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0904_RS04740	COG0312	modulator of DNA gyrase
H0904_RS04750	COG2732	(Barnase) inhibitor
H0904_RS04770	COG3028	Belongs to the UPF0307 family
H0904_RS04775	COG0312	modulator of DNA gyrase
H0904_RS04780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0904_RS04785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS04790	COG1660	Displays ATPase and GTPase activities
H0904_RS04800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0904_RS04805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H0904_RS04810	COG1137	ATPase activity
H0904_RS04815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0904_RS04820	COG3117	lipopolysaccharide transmembrane transporter activity
H0904_RS04825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0904_RS04830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0904_RS04830	COG0517	IMP dehydrogenase activity
H0904_RS04835	COG1127	ABC transporter
H0904_RS04840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0904_RS04845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0904_RS04850	COG2854	intermembrane phospholipid transfer
H0904_RS04860	COG5007	Belongs to the BolA IbaG family
H0904_RS04865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0904_RS04870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0904_RS04875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0904_RS04880	COG3105	Protein conserved in bacteria
H0904_RS04885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0904_RS04890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0904_RS04895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0904_RS04900	COG0625	glutathione transferase activity
H0904_RS04905	COG2969	positive regulation of protein catabolic process
H0904_RS04910	COG0493	'glutamate synthase
H0904_RS04915	COG2198	Histidine kinase
H0904_RS04915	COG5002	protein histidine kinase activity
H0904_RS04915	COG0784	Response regulator, receiver
H0904_RS04920	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H0904_RS04925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0904_RS04930	COG2823	Periplasmic or secreted lipoprotein
H0904_RS04935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H0904_RS04940	COG0792	nuclease activity
H0904_RS04950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0904_RS04960	COG0348	domain, Protein
H0904_RS04975	COG3964	amidohydrolase
H0904_RS05005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS05005	COG3711	transcriptional antiterminator
H0904_RS05010	COG1741	Belongs to the pirin family
H0904_RS05015	COG0583	DNA-binding transcription factor activity
H0904_RS05020	COG2259	Doxx family
H0904_RS05030	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H0904_RS05035	COG4575	ribosome binding
H0904_RS05040	COG0586	Pfam SNARE associated Golgi protein
H0904_RS05045	COG0861	Integral membrane protein TerC family
H0904_RS05050	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H0904_RS05060	COG1469	GTP cyclohydrolase I activity
H0904_RS05065	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0904_RS05065	COG1902	pentaerythritol trinitrate reductase activity
H0904_RS05090	COG3501	Rhs element vgr protein
H0904_RS05125	COG0590	tRNA wobble adenosine to inosine editing
H0904_RS05135	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS05140	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H0904_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS05160	COG2271	Major facilitator Superfamily
H0904_RS05175	COG1414	Transcriptional regulator
H0904_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS05195	COG2146	nitrite reductase [NAD(P)H] activity
H0904_RS05205	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H0904_RS05210	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H0904_RS05215	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS05220	COG5557	Pfam Polysulphide reductase, NrfD
H0904_RS05225	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H0904_RS05230	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H0904_RS05235	COG1773	rubredoxin
H0904_RS05245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H0904_RS05250	COG0298	carbon dioxide binding
H0904_RS05255	COG0409	Hydrogenase expression formation protein
H0904_RS05260	COG0309	Hydrogenase expression formation protein (HypE)
H0904_RS05270	COG0830	nickel cation binding
H0904_RS05275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H0904_RS05315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0904_RS05325	COG1124	(ABC) transporter
H0904_RS05375	COG2226	methyltransferase
H0904_RS05400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0904_RS05410	COG2271	Major facilitator Superfamily
H0904_RS05425	COG2814	Major facilitator Superfamily
H0904_RS05440	COG0358	DNA primase activity
H0904_RS05445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0904_RS05450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0904_RS05455	COG0840	transmembrane signaling receptor activity
H0904_RS05460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H0904_RS05465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0904_RS05470	COG0617	tRNA 3'-terminal CCA addition
H0904_RS05475	COG4991	sh3 domain protein
H0904_RS05480	COG3025	triphosphatase activity
H0904_RS05485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0904_RS05490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H0904_RS05490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H0904_RS05505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0904_RS05510	COG3384	dioxygenase
H0904_RS05515	COG0754	glutathionylspermidine amidase activity
H0904_RS05520	COG5463	Belongs to the UPF0441 family
H0904_RS05530	COG0494	nUDIX hydrolase
H0904_RS05535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0904_RS05540	COG3150	esterase
H0904_RS05545	COG0187	DNA topoisomerase II activity
H0904_RS05555	COG0204	Acyl-transferase
H0904_RS05560	COG2132	Multicopper oxidase
H0904_RS05565	COG1280	lysine exporter protein (LysE YggA)
H0904_RS05570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0904_RS05575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0904_RS05580	COG2967	ApaG domain
H0904_RS05585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0904_RS05590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0904_RS05595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0904_RS05600	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H0904_RS05605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H0904_RS05610	COG0564	pseudouridine synthase activity
H0904_RS05615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0904_RS05620	COG0417	DNA replication proofreading
H0904_RS05625	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H0904_RS05630	COG1178	ABC-type Fe3 transport system permease component
H0904_RS05635	COG4143	(ABC) transporter
H0904_RS05640	COG0494	nUDIX hydrolase
H0904_RS05650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0904_RS05665	COG4795	General secretion pathway protein
H0904_RS05680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0904_RS05690	COG1074	ATP-dependent DNA helicase activity
H0904_RS05695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0904_RS05705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0904_RS05705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0904_RS05710	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0904_RS05730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H0904_RS05735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0904_RS05740	COG2166	iron-sulfur cluster assembly
H0904_RS05745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0904_RS05750	COG0583	DNA-binding transcription factor activity
H0904_RS05755	COG2363	Small membrane protein
H0904_RS05770	COG1611	Belongs to the LOG family
H0904_RS05790	COG3098	single-species biofilm formation
H0904_RS05795	COG0564	pseudouridine synthase activity
H0904_RS05800	COG0716	FMN binding
H0904_RS05815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0904_RS05830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0904_RS05835	COG0528	UMP kinase activity
H0904_RS05840	COG0233	cytoplasmic translational termination
H0904_RS05845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H0904_RS05850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0904_RS05855	COG0575	Belongs to the CDS family
H0904_RS05860	COG0750	zinc metalloprotease
H0904_RS05865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0904_RS05875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0904_RS05880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0904_RS05890	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0904_RS05895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0904_RS05915	COG0037	tRNA processing
H0904_RS05920	COG4568	rho-dependent transcription termination
H0904_RS05925	COG3015	lipoprotein NlpE involved in copper resistance
H0904_RS05930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0904_RS05935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H0904_RS05940	COG1447	Phosphotransferase system cellobiose-specific component IIA
H0904_RS05945	COG2169	Transcriptional regulator
H0904_RS05945	COG1917	Cupin 2, conserved barrel domain protein
H0904_RS05950	COG1486	melibiose metabolic process
H0904_RS05960	COG0442	prolyl-tRNA aminoacylation
H0904_RS05965	COG1720	tRNA m6t6A37 methyltransferase activity
H0904_RS05975	COG1464	Belongs to the NlpA lipoprotein family
H0904_RS05980	COG2011	ABC-type metal ion transport system permease component
H0904_RS05985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0904_RS05990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0904_RS06030	COG0640	Transcriptional regulator
H0904_RS06045	COG5544	Lipoprotein
H0904_RS06050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0904_RS06065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0904_RS06070	COG2814	Major facilitator Superfamily
H0904_RS06075	COG1566	PFAM secretion protein HlyD family protein
H0904_RS06080	COG1846	Transcriptional regulator
H0904_RS06085	COG2814	Major facilitator Superfamily
H0904_RS06090	COG2113	Glycine betaine
H0904_RS06095	COG4176	ABC-type proline glycine betaine transport system permease component
H0904_RS06100	COG4175	Glycine betaine
H0904_RS06115	COG1780	Probably involved in ribonucleotide reductase function
H0904_RS06120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0904_RS06125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0904_RS06130	COG1278	Cold shock
H0904_RS06135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0904_RS06140	COG0321	lipoyl(octanoyl) transferase activity
H0904_RS06145	COG2921	Belongs to the UPF0250 family
H0904_RS06150	COG1686	Belongs to the peptidase S11 family
H0904_RS06155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0904_RS06160	COG0772	Belongs to the SEDS family
H0904_RS06165	COG0768	penicillin binding
H0904_RS06170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0904_RS06175	COG0799	negative regulation of ribosome biogenesis
H0904_RS06190	COG1466	dna polymerase III delta subunit
H0904_RS06195	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H0904_RS06200	COG0495	leucyl-tRNA aminoacylation
H0904_RS06210	COG1126	abc transporter atp-binding protein
H0904_RS06215	COG0765	amino acid transport
H0904_RS06220	COG0765	amino acid transport
H0904_RS06240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0904_RS06240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0904_RS06245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0904_RS06270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0904_RS06275	COG4535	Mg2 and Co2 transporter CorC
H0904_RS06280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0904_RS06285	COG1702	phosphate starvation-inducible protein PhoH
H0904_RS06290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0904_RS06295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0904_RS06300	COG1301	dicarboxylic acid transport
H0904_RS06345	COG1846	Transcriptional regulator
H0904_RS06345	COG1940	carbohydrate kinase activity
H0904_RS06350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H0904_RS06355	COG0363	glucosamine-6-phosphate deaminase activity
H0904_RS06360	COG2190	(PTS) system
H0904_RS06360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS06360	COG1263	PTS System
H0904_RS06380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0904_RS06390	COG0745	RESPONSE REGULATOR receiver
H0904_RS06395	COG2205	protein histidine kinase activity
H0904_RS06400	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0904_RS06405	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0904_RS06425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0904_RS06440	COG3501	Rhs element vgr protein
H0904_RS06500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0904_RS06505	COG2814	Major facilitator Superfamily
H0904_RS06525	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0904_RS06530	COG1053	succinate dehydrogenase
H0904_RS06540	COG0567	Dehydrogenase, E1 component
H0904_RS06545	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0904_RS06550	COG0045	succinate-CoA ligase (ADP-forming) activity
H0904_RS06555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0904_RS06560	COG1271	oxidase subunit
H0904_RS06565	COG1294	oxidase, subunit
H0904_RS06570	COG4890	Cyd operon protein YbgT
H0904_RS06580	COG0824	Thioesterase
H0904_RS06585	COG0811	peptide transport
H0904_RS06590	COG0848	biopolymer transport protein
H0904_RS06595	COG3064	Membrane
H0904_RS06600	COG0823	Involved in the tonB-independent uptake of proteins
H0904_RS06605	COG2885	chlorophyll binding
H0904_RS06610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H0904_RS06645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0904_RS06655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0904_RS06670	COG0588	phosphoglycerate mutase activity
H0904_RS06680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0904_RS06685	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0904_RS06685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0904_RS06685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0904_RS06690	COG0383	alpha-mannosidase activity
H0904_RS06695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS06695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS06695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0904_RS06695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS06695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS06695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0904_RS06715	COG1119	ATPase activity
H0904_RS06720	COG3585	molybdate ion transport
H0904_RS06720	COG2005	Transcriptional regulator
H0904_RS06735	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0904_RS06740	COG4149	molybdate abc transporter
H0904_RS06745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0904_RS06750	COG0246	Mannitol dehydrogenase
H0904_RS06755	COG0477	Major facilitator Superfamily
H0904_RS06765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H0904_RS06775	COG0561	phosphatase activity
H0904_RS06780	COG2706	6-phosphogluconolactonase activity
H0904_RS06790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0904_RS06800	COG2226	methyltransferase
H0904_RS06810	COG0556	nucleotide-excision repair
H0904_RS06820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0904_RS06830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H0904_RS06835	COG0314	molybdopterin synthase activity
H0904_RS06840	COG0670	Belongs to the BI1 family
H0904_RS06845	COG0842	Transport permease protein
H0904_RS06850	COG0842	Transport permease protein
H0904_RS06855	COG1131	(ABC) transporter
H0904_RS06865	COG1309	transcriptional regulator
H0904_RS06870	COG0513	Belongs to the DEAD box helicase family
H0904_RS06875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0904_RS06880	COG2261	transglycosylase associated protein
H0904_RS06885	COG2897	thiosulfate sulfurtransferase activity
H0904_RS06905	COG5006	permease, DMT superfamily
H0904_RS06920	COG0488	(ABC) transporter
H0904_RS06925	COG2824	Alkylphosphonate utilization operon protein PhnA
H0904_RS06930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0904_RS06935	COG0303	'Molybdopterin
H0904_RS06940	COG0302	gtp cyclohydrolase
H0904_RS06945	COG2311	Membrane
H0904_RS06950	COG2949	membrane
H0904_RS06965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS06965	COG1263	PTS System
H0904_RS06985	COG0281	malic enzyme
H0904_RS07035	COG0295	cytidine deaminase activity
H0904_RS07040	COG1346	cytolysis
H0904_RS07045	COG1380	Effector of murein hydrolase LrgA
H0904_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0904_RS07050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0904_RS07055	COG0489	protein tyrosine kinase activity
H0904_RS07065	COG0501	Belongs to the peptidase M48B family
H0904_RS07070	COG0572	uridine kinase
H0904_RS07075	COG0717	Belongs to the dCTP deaminase family
H0904_RS07080	COG2982	Protein involved in outer membrane biogenesis
H0904_RS07090	COG1253	flavin adenine dinucleotide binding
H0904_RS07120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0904_RS07135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0904_RS07135	COG0140	phosphoribosyl-ATP diphosphatase activity
H0904_RS07140	COG0107	imidazoleglycerol-phosphate synthase activity
H0904_RS07145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0904_RS07155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0904_RS07155	COG0131	Imidazoleglycerol-phosphate dehydratase
H0904_RS07160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0904_RS07160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0904_RS07165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0904_RS07165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0904_RS07175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0904_RS07180	COG0625	glutathione transferase activity
H0904_RS07185	COG1686	Belongs to the peptidase S11 family
H0904_RS07190	COG1760	l-serine dehydratase
H0904_RS07195	COG0814	amino acid
H0904_RS07200	COG0671	phosphoesterase, PA-phosphatase related
H0904_RS07205	COG0432	Pfam Uncharacterised protein family UPF0047
H0904_RS07225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0904_RS07230	COG4160	amino acid transport
H0904_RS07235	COG4215	(ABC) transporter
H0904_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0904_RS07245	COG1126	abc transporter atp-binding protein
H0904_RS07250	COG0702	epimerase
H0904_RS07255	COG2431	L-lysine efflux transmembrane transporter activity
H0904_RS07260	COG3593	DNA synthesis involved in DNA repair
H0904_RS07265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0904_RS07270	COG1136	(ABC) transporter
H0904_RS07270	COG0577	efflux transmembrane transporter activity
H0904_RS07280	COG2271	Major facilitator Superfamily
H0904_RS07285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0904_RS07285	COG0473	3-isopropylmalate dehydrogenase activity
H0904_RS07290	COG2186	Transcriptional regulator
H0904_RS07300	COG3153	acetyltransferase
H0904_RS07300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0904_RS07305	COG1414	Transcriptional regulator
H0904_RS07315	COG1278	Cold shock
H0904_RS07320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0904_RS07325	COG0542	response to heat
H0904_RS07330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0904_RS07335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0904_RS07340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H0904_RS07350	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H0904_RS07355	COG0492	ferredoxin-NADP+ reductase activity
H0904_RS07360	COG1522	sequence-specific DNA binding
H0904_RS07365	COG3107	peptidoglycan biosynthetic process
H0904_RS07365	COG1674	ftsk spoiiie
H0904_RS07370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0904_RS07375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0904_RS07380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0904_RS07390	COG0583	DNA-binding transcription factor activity
H0904_RS07410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H0904_RS07415	COG1882	Formate acetyltransferase
H0904_RS07420	COG2116	formate transmembrane transporter activity
H0904_RS07425	COG1414	Transcriptional regulator
H0904_RS07430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0904_RS07435	COG2271	Major facilitator Superfamily
H0904_RS07440	COG2721	sulfolactate sulfo-lyase activity
H0904_RS07445	COG1944	ATP diphosphatase activity
H0904_RS07450	COG0252	asparaginase activity
H0904_RS07465	COG0735	belongs to the Fur family
H0904_RS07470	COG0716	FMN binding
H0904_RS07490	COG2274	protein secretion by the type I secretion system
H0904_RS07495	COG0596	Alpha beta hydrolase
H0904_RS07500	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H0904_RS07505	COG0033	Phosphoglucomutase
H0904_RS07510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H0904_RS07515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0904_RS07520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0904_RS07525	COG0539	negative regulation of cytoplasmic translation
H0904_RS07530	COG0776	regulation of translation
H0904_RS07555	COG1132	(ABC) transporter
H0904_RS07560	COG1663	tetraacyldisaccharide 4'-kinase activity
H0904_RS07575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H0904_RS07580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H0904_RS07585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0904_RS07590	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H0904_RS07595	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H0904_RS07605	COG2989	Protein conserved in bacteria
H0904_RS07610	COG3108	Peptidase M15
H0904_RS07615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0904_RS07625	COG1448	Aminotransferase
H0904_RS07635	COG0017	Asparaginyl-tRNA synthetase
H0904_RS07640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H0904_RS07645	COG0308	aminopeptidase N
H0904_RS07650	COG0167	dihydroorotate dehydrogenase activity
H0904_RS07660	COG3217	Mosc domain protein beta barrel domain protein
H0904_RS07660	COG0633	Ferredoxin
H0904_RS07665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H0904_RS07665	COG0116	Belongs to the methyltransferase superfamily
H0904_RS07670	COG0488	(ABC) transporter
H0904_RS07675	COG2995	paraquat-inducible protein a
H0904_RS07680	COG3008	intermembrane lipid transfer
H0904_RS07680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0904_RS07685	COG3009	Protein conserved in bacteria
H0904_RS07690	COG3130	regulation of translation
H0904_RS07700	COG1067	ATP-dependent peptidase activity
H0904_RS07720	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
H0904_RS07725	COG3070	regulator of competence-specific genes
H0904_RS07730	COG1289	transmembrane transporter activity
H0904_RS07735	COG0210	DNA helicase
H0904_RS07740	COG1803	Methylglyoxal synthase
H0904_RS07745	COG1832	CoA-binding protein
H0904_RS07750	COG3785	DNA binding
H0904_RS07755	COG1254	Belongs to the acylphosphatase family
H0904_RS07760	COG2920	part of a sulfur-relay system
H0904_RS07790	COG3501	Rhs element vgr protein
H0904_RS07920	COG2388	GCN5-related N-acetyl-transferase
H0904_RS07935	COG3585	molybdate ion transport
H0904_RS07935	COG2005	Transcriptional regulator
H0904_RS07945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0904_RS07970	COG1742	UPF0060 membrane protein
H0904_RS07980	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS07985	COG2864	formate dehydrogenase
H0904_RS07995	COG0456	acetyltransferase
H0904_RS08005	COG0519	Catalyzes the synthesis of GMP from XMP
H0904_RS08020	COG1607	acyl-coa hydrolase
H0904_RS08040	COG3104	oligopeptide transport
H0904_RS08045	COG2814	Major facilitator Superfamily
H0904_RS08050	COG1560	Kdo2-lipid A biosynthetic process
H0904_RS08080	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H0904_RS08085	COG3683	transport system, periplasmic component
H0904_RS08095	COG0071	Belongs to the small heat shock protein (HSP20) family
H0904_RS08110	COG0418	dihydroorotase activity
H0904_RS08150	COG1285	pathogenesis
H0904_RS08170	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0904_RS08170	COG0506	proline dehydrogenase activity
H0904_RS08170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0904_RS08180	COG1113	amino acid transport
H0904_RS08195	COG1598	PFAM Uncharacterised protein family UPF0150
H0904_RS08225	COG0835	chemotaxis
H0904_RS08235	COG0840	transmembrane signaling receptor activity
H0904_RS08240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H0904_RS08245	COG2201	protein-glutamate methylesterase activity
H0904_RS08250	COG0745	RESPONSE REGULATOR receiver
H0904_RS08280	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H0904_RS08305	COG1815	bacterial-type flagellum-dependent cell motility
H0904_RS08310	COG1558	bacterial-type flagellum-dependent cell motility
H0904_RS08315	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H0904_RS08335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H0904_RS08340	COG1706	bacterial-type flagellum-dependent cell motility
H0904_RS08385	COG1338	Plays a role in the flagellum-specific transport system
H0904_RS08395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H0904_RS08405	COG1580	Controls the rotational direction of flagella during chemotaxis
H0904_RS08415	COG2882	bacterial-type flagellum organization
H0904_RS08425	COG1317	bacterial-type flagellum organization
H0904_RS08435	COG1766	The M ring may be actively involved in energy transduction
H0904_RS08440	COG1677	Flagellar hook-basal body complex protein FliE
H0904_RS08450	COG1278	Cold shock
H0904_RS08460	COG5510	response to toxic substance
H0904_RS08480	COG0242	peptide deformylase activity
H0904_RS08510	COG1191	sigma factor activity
H0904_RS08530	COG3210	domain, Protein
H0904_RS08560	COG0800	Aldolase
H0904_RS08565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS08580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0904_RS08585	COG1309	transcriptional regulator
H0904_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS08595	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H0904_RS08605	COG0471	metal ion transport
H0904_RS08625	COG1902	pentaerythritol trinitrate reductase activity
H0904_RS08630	COG2851	Citrate transporter
H0904_RS08635	COG2720	vancomycin resistance protein
H0904_RS08650	COG2828	Protein conserved in bacteria
H0904_RS08655	COG0471	metal ion transport
H0904_RS08670	COG3051	citrate lyase alpha subunit
H0904_RS08675	COG2301	Belongs to the HpcH HpaI aldolase family
H0904_RS08685	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H0904_RS08690	COG3290	protein histidine kinase activity
H0904_RS08695	COG4565	transcriptional regulatory protein
H0904_RS08710	COG1494	fructose-1,6-bisphosphatase
H0904_RS08745	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H0904_RS08750	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0904_RS08755	COG2197	response regulator
H0904_RS08760	COG0322	excinuclease ABC activity
H0904_RS08765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0904_RS08800	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0904_RS08840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0904_RS08845	COG1349	DNA-binding transcription factor activity
H0904_RS08850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0904_RS08885	COG1683	Conserved Protein
H0904_RS08895	COG3037	sugar-specific permease SgaT UlaA
H0904_RS08910	COG1609	Transcriptional regulator
H0904_RS08940	COG1069	ribulokinase activity
H0904_RS08955	COG0390	transport system, permease component
H0904_RS08960	COG4619	ABC transporter
H0904_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS08970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0904_RS08975	COG0698	ribose 5-phosphate isomerase
H0904_RS08980	COG1063	alcohol dehydrogenase
H0904_RS08985	COG2814	Major facilitator Superfamily
H0904_RS08990	COG2376	Dihydroxyacetone kinase
H0904_RS08995	COG1461	Dihydroxyacetone kinase
H0904_RS09000	COG2390	Transcriptional regulator
H0904_RS09015	COG0246	Mannitol dehydrogenase
H0904_RS09020	COG1070	Carbohydrate kinase
H0904_RS09040	COG1473	amidohydrolase
H0904_RS09065	COG3422	double-strand break repair
H0904_RS09125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H0904_RS09170	COG4626	Terminase
H0904_RS09170	COG1802	Transcriptional regulator
H0904_RS09180	COG4725	Belongs to the MT-A70-like family
H0904_RS09200	COG1403	HNH endonuclease
H0904_RS09225	COG3772	lysozyme
H0904_RS09335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0904_RS09340	COG0727	PFAM Uncharacterised protein family (UPF0153)
H0904_RS09350	COG1988	membrane-bound metal-dependent
H0904_RS09365	COG3001	Fructosamine kinase
H0904_RS09370	COG0542	response to heat
H0904_RS09375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H0904_RS09380	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H0904_RS09380	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H0904_RS09390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0904_RS09395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0904_RS09400	COG1121	(ABC) transporter
H0904_RS09405	COG0803	Belongs to the bacterial solute-binding protein 9 family
H0904_RS09440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0904_RS09445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0904_RS09455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0904_RS09460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0904_RS09470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0904_RS09475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0904_RS09475	COG0072	phenylalanine-tRNA ligase activity
H0904_RS09480	COG0776	regulation of translation
H0904_RS09490	COG4139	cobalamin transport
H0904_RS09495	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H0904_RS09500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0904_RS09505	COG0463	Glycosyl transferase, family 2
H0904_RS09510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0904_RS09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0904_RS09515	COG0726	polysaccharide deacetylase
H0904_RS09520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0904_RS09525	COG2076	Multidrug Resistance protein
H0904_RS09530	COG2076	Multidrug Resistance protein
H0904_RS09535	COG0791	NLP P60 protein
H0904_RS09545	COG2207	Transcriptional regulator
H0904_RS09550	COG3720	iron ion transport
H0904_RS09565	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H0904_RS09570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0904_RS09570	COG0574	Belongs to the PEP-utilizing enzyme family
H0904_RS09575	COG0628	permease
H0904_RS09580	COG0247	lactate metabolic process
H0904_RS09580	COG0277	FAD linked oxidase domain protein
H0904_RS09585	COG2050	protein possibly involved in aromatic compounds catabolism
H0904_RS09590	COG0316	Belongs to the HesB IscA family
H0904_RS09595	COG0719	Fe-S assembly protein
H0904_RS09600	COG0396	ATPase activity
H0904_RS09605	COG0719	Fe-S assembly protein
H0904_RS09610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0904_RS09615	COG2166	iron-sulfur cluster assembly
H0904_RS09620	COG1376	ErfK ybiS ycfS ynhG family protein
H0904_RS09620	COG1388	LysM domain
H0904_RS09625	COG4238	major outer membrane lipoprotein
H0904_RS09630	COG0469	pyruvate kinase activity
H0904_RS09650	COG0534	Mate efflux family protein
H0904_RS09655	COG0307	riboflavin synthase, alpha
H0904_RS09670	COG2814	Major facilitator Superfamily
H0904_RS09675	COG0583	DNA-binding transcription factor activity
H0904_RS09680	COG1609	Transcriptional regulator
H0904_RS09690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0904_RS09695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0904_RS09700	COG0346	lactoylglutathione lyase activity
H0904_RS09705	COG3313	Fe-S protein
H0904_RS09710	COG1846	Transcriptional regulator
H0904_RS09715	COG3133	Outer membrane lipoprotein
H0904_RS09720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0904_RS09725	COG0259	pyridoxamine-phosphate oxidase activity
H0904_RS09730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0904_RS09735	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H0904_RS09745	COG3739	integral membrane protein
H0904_RS09750	COG4172	Belongs to the ABC transporter superfamily
H0904_RS09760	COG4171	peptide transport system, permease
H0904_RS09770	COG4166	transmembrane transport
H0904_RS09780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H0904_RS09785	COG1842	Phage shock protein A
H0904_RS09795	COG1983	PspC domain protein
H0904_RS09800	COG3106	COG3106 Predicted ATPase
H0904_RS09805	COG3768	UPF0283 membrane protein
H0904_RS09825	COG4166	transmembrane transport
H0904_RS09830	COG0598	Magnesium transport protein CorA
H0904_RS09835	COG0037	tRNA processing
H0904_RS09840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H0904_RS09865	COG1794	racemase activity, acting on amino acids and derivatives
H0904_RS09880	COG0791	NLP P60 protein
H0904_RS09885	COG0673	inositol 2-dehydrogenase activity
H0904_RS09895	COG0589	response to stress
H0904_RS09905	COG0589	response to stress
H0904_RS09930	COG2966	Psort location CytoplasmicMembrane, score
H0904_RS09935	COG3610	response to peptide
H0904_RS09940	COG2356	endonuclease I
H0904_RS09945	COG1702	phosphate starvation-inducible protein PhoH
H0904_RS09950	COG3443	Belongs to the bacterial solute-binding protein 9 family
H0904_RS09955	COG2375	cellular response to nickel ion
H0904_RS09965	COG1294	oxidase, subunit
H0904_RS09970	COG1271	oxidase subunit
H0904_RS09975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0904_RS09985	COG1280	lysine exporter protein (LysE YggA)
H0904_RS10005	COG0243	molybdopterin cofactor binding
H0904_RS10010	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS10020	COG4772	TonB-dependent receptor
H0904_RS10035	COG1288	antiporter activity
H0904_RS10050	COG3961	Belongs to the TPP enzyme family
H0904_RS10055	COG0583	DNA-binding transcription factor activity
H0904_RS10060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H0904_RS10085	COG3188	usher protein
H0904_RS10105	COG0012	GTP binding
H0904_RS10110	COG0193	aminoacyl-tRNA hydrolase activity
H0904_RS10120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0904_RS10125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H0904_RS10130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0904_RS10135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0904_RS10140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0904_RS10145	COG2890	protein-(glutamine-N5) methyltransferase activity
H0904_RS10160	COG1242	4 iron, 4 sulfur cluster binding
H0904_RS10170	COG0659	secondary active sulfate transmembrane transporter activity
H0904_RS10175	COG0671	phosphoesterase, PA-phosphatase related
H0904_RS10175	COG2453	phosphatase
H0904_RS10180	COG2267	carboxylic ester hydrolase activity
H0904_RS10185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0904_RS10190	COG4977	sequence-specific DNA binding
H0904_RS10200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0904_RS10205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0904_RS10210	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS10215	COG1115	amino acid carrier protein
H0904_RS10225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0904_RS10230	COG3381	protein complex oligomerization
H0904_RS10240	COG0477	Major facilitator Superfamily
H0904_RS10245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0904_RS10265	COG0018	arginyl-trna synthetase
H0904_RS10270	COG3102	Protein conserved in bacteria
H0904_RS10275	COG3142	Participates in the control of copper homeostasis
H0904_RS10280	COG0243	molybdopterin cofactor binding
H0904_RS10285	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS10290	COG3302	dmso reductase anchor subunit
H0904_RS10295	COG0500	methyltransferase
H0904_RS10300	COG2226	methyltransferase
H0904_RS10305	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H0904_RS10320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0904_RS10325	COG0494	nUDIX hydrolase
H0904_RS10330	COG0217	transcriptional regulatory protein
H0904_RS10335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H0904_RS10340	COG0632	four-way junction helicase activity
H0904_RS10345	COG2255	four-way junction helicase activity
H0904_RS10350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0904_RS10355	COG1121	(ABC) transporter
H0904_RS10360	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H0904_RS10365	COG0739	heme binding
H0904_RS10370	COG1560	Kdo2-lipid A biosynthetic process
H0904_RS10375	COG0583	DNA-binding transcription factor activity
H0904_RS10390	COG3188	usher protein
H0904_RS10400	COG0469	pyruvate kinase activity
H0904_RS10405	COG1737	Transcriptional regulator
H0904_RS10410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H0904_RS10420	COG2076	Multidrug Resistance protein
H0904_RS10425	COG2076	Multidrug Resistance protein
H0904_RS10430	COG0251	oxidation-reduction process
H0904_RS10435	COG1199	ATP-dependent helicase activity
H0904_RS10445	COG3065	identical protein binding
H0904_RS10450	COG0318	PFAM AMP-dependent synthetase and ligase
H0904_RS10455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0904_RS10480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H0904_RS10485	COG2894	cell division
H0904_RS10490	COG0850	regulation of cytokinetic process
H0904_RS10495	COG3100	YcgL domain-containing protein
H0904_RS10500	COG2951	lytic endotransglycosylase activity
H0904_RS10505	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0904_RS10510	COG2983	Belongs to the UPF0260 family
H0904_RS10520	COG3042	response to heat
H0904_RS10555	COG2999	glutathione oxidoreductase activity
H0904_RS10565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0904_RS10570	COG2911	Protein conserved in bacteria
H0904_RS10580	COG3784	Protein of unknown function (DUF1318)
H0904_RS10590	COG1643	Atp-dependent helicase
H0904_RS10595	COG0531	amino acid
H0904_RS10605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H0904_RS10610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H0904_RS10620	COG1309	transcriptional regulator
H0904_RS10625	COG0589	response to stress
H0904_RS10630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0904_RS10635	COG0604	alcohol dehydrogenase
H0904_RS10635	COG3321	synthase
H0904_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS10645	COG0814	amino acid
H0904_RS10660	COG0488	(ABC) transporter
H0904_RS10670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0904_RS10675	COG1129	ABC transporter
H0904_RS10675	COG0842	Transport permease protein
H0904_RS10680	COG0842	Transport permease protein
H0904_RS10690	COG3634	alkyl hydroperoxide reductase activity
H0904_RS10705	COG1403	HNH endonuclease
H0904_RS10730	COG1126	abc transporter atp-binding protein
H0904_RS10735	COG0765	amino acid transport
H0904_RS10750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0904_RS10765	COG0825	malonyl-CoA metabolic process
H0904_RS10770	COG0583	DNA-binding transcription factor activity
H0904_RS10775	COG5654	RES domain protein
H0904_RS10780	COG5642	Protein of unknown function (DUF2384)
H0904_RS10785	COG4807	Protein conserved in bacteria
H0904_RS10820	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0904_RS10840	COG2223	nitrite transmembrane transporter activity
H0904_RS10865	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0904_RS10890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0904_RS10890	COG2169	Transcriptional regulator
H0904_RS10895	COG2211	Major facilitator Superfamily
H0904_RS10900	COG2814	Major facilitator Superfamily
H0904_RS10905	COG2814	Major facilitator Superfamily
H0904_RS10910	COG1979	alcohol dehydrogenase
H0904_RS10945	COG0251	oxidation-reduction process
H0904_RS10950	COG3831	ATPase activity
H0904_RS10955	COG0714	Associated with various cellular activities
H0904_RS10965	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H0904_RS10975	COG1846	Transcriptional regulator
H0904_RS10980	COG0697	spore germination
H0904_RS11000	COG1309	transcriptional regulator
H0904_RS11015	COG1671	Belongs to the UPF0178 family
H0904_RS11020	COG1280	lysine exporter protein (LysE YggA)
H0904_RS11025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H0904_RS11040	COG1802	Transcriptional regulator
H0904_RS11070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H0904_RS11075	COG1940	carbohydrate kinase activity
H0904_RS11080	COG0583	DNA-binding transcription factor activity
H0904_RS11085	COG2814	Major facilitator Superfamily
H0904_RS11090	COG3397	chitin binding
H0904_RS11100	COG0114	fumarate hydratase activity
H0904_RS11105	COG1482	cell wall glycoprotein biosynthetic process
H0904_RS11110	COG5339	Protein conserved in bacteria
H0904_RS11120	COG0385	Bile acid
H0904_RS11125	COG0673	inositol 2-dehydrogenase activity
H0904_RS11135	COG4657	Part of a membrane complex involved in electron transport
H0904_RS11145	COG4656	Part of a membrane complex involved in electron transport
H0904_RS11155	COG4659	FMN binding
H0904_RS11165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0904_RS11170	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H0904_RS11180	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
H0904_RS11190	COG0023	Translation Initiation Factor
H0904_RS11195	COG0284	orotidine-5'-phosphate decarboxylase activity
H0904_RS11200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H0904_RS11205	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H0904_RS11210	COG0671	phosphoesterase, PA-phosphatase related
H0904_RS11215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0904_RS11220	COG0113	porphobilinogen synthase activity
H0904_RS11235	COG0583	DNA-binding transcription factor activity
H0904_RS11250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0904_RS11260	COG0616	signal peptide processing
H0904_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS11270	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H0904_RS11275	COG3210	domain, Protein
H0904_RS11280	COG3210	domain, Protein
H0904_RS11285	COG3700	Belongs to the class B bacterial acid phosphatase family
H0904_RS11290	COG1187	pseudouridine synthase activity
H0904_RS11295	COG0009	L-threonylcarbamoyladenylate synthase
H0904_RS11310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0904_RS11310	COG0512	Glutamine amidotransferase of anthranilate synthase
H0904_RS11315	COG0512	Glutamine amidotransferase of anthranilate synthase
H0904_RS11315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0904_RS11320	COG0134	indole-3-glycerol-phosphate synthase activity
H0904_RS11320	COG0135	phosphoribosylanthranilate isomerase activity
H0904_RS11325	COG0133	tryptophan synthase activity
H0904_RS11330	COG0159	tryptophan synthase activity
H0904_RS11335	COG3210	domain, Protein
H0904_RS11340	COG2831	hemolysin activation secretion protein
H0904_RS11345	COG3047	cAMP biosynthetic process
H0904_RS11360	COG2917	probably involved in intracellular septation
H0904_RS11375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H0904_RS11385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0904_RS11395	COG4608	Belongs to the ABC transporter superfamily
H0904_RS11405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0904_RS11410	COG0601	transmembrane transport
H0904_RS11425	COG2095	MarC family integral membrane protein
H0904_RS11430	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS11430	COG1454	alcohol dehydrogenase
H0904_RS11450	COG2916	Histone family protein nucleoid-structuring protein H-NS
H0904_RS11455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0904_RS11460	COG0745	RESPONSE REGULATOR receiver
H0904_RS11465	COG3012	SEC-C Motif Domain Protein
H0904_RS11470	COG0788	formyltetrahydrofolate deformylase activity
H0904_RS11480	COG0583	DNA-binding transcription factor activity
H0904_RS11485	COG0708	Exodeoxyribonuclease III
H0904_RS11490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0904_RS11495	COG0709	Synthesizes selenophosphate from selenide and ATP
H0904_RS11500	COG0778	Nitroreductase
H0904_RS11505	COG0616	signal peptide processing
H0904_RS11510	COG0252	asparaginase activity
H0904_RS11515	COG1335	isochorismatase
H0904_RS11520	COG3139	Protein of unknown function (DUF1315)
H0904_RS11525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0904_RS11540	COG3713	MltA-interacting MipA family protein
H0904_RS11545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0904_RS11550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0904_RS11555	COG2186	Transcriptional regulator
H0904_RS11560	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0904_RS11565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H0904_RS11585	COG2814	Major facilitator Superfamily
H0904_RS11600	COG1115	amino acid carrier protein
H0904_RS11605	COG0501	Belongs to the peptidase M48B family
H0904_RS11620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H0904_RS11625	COG1956	GAF domain-containing protein
H0904_RS11630	COG2995	paraquat-inducible protein a
H0904_RS11635	COG3008	intermembrane lipid transfer
H0904_RS11650	COG1276	copper resistance
H0904_RS11655	COG2372	response to copper ion
H0904_RS11660	COG1528	Iron-storage protein
H0904_RS11675	COG3140	Belongs to the UPF0181 family
H0904_RS11680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0904_RS11685	COG0494	nUDIX hydrolase
H0904_RS11690	COG1760	l-serine dehydratase
H0904_RS11695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS11695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS11700	COG3715	PTS system
H0904_RS11705	COG3716	PTS system mannose fructose sorbose family IID component
H0904_RS11710	COG4811	Protein of unknown function (DUF986)
H0904_RS11715	COG1971	Probably functions as a manganese efflux pump
H0904_RS11720	COG2226	methyltransferase
H0904_RS11730	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H0904_RS11740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H0904_RS11745	COG0667	Aldo Keto reductase
H0904_RS11755	COG0386	Belongs to the glutathione peroxidase family
H0904_RS12015	COG0582	viral genome integration into host DNA
H0904_RS12020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0904_RS12020	COG0519	Catalyzes the synthesis of GMP from XMP
H0904_RS12025	COG0517	IMP dehydrogenase activity
H0904_RS12025	COG0516	GMP reductase activity
H0904_RS12030	COG1570	exodeoxyribonuclease VII activity
H0904_RS12035	COG1629	transport
H0904_RS12035	COG4206	TonB-dependent receptor
H0904_RS12040	COG1770	oligopeptidase
H0904_RS12055	COG0281	malic enzyme
H0904_RS12055	COG0280	phosphate acetyltransferase
H0904_RS12060	COG2197	response regulator
H0904_RS12065	COG1393	Belongs to the ArsC family
H0904_RS12070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0904_RS12075	COG1876	peptidase activity
H0904_RS12080	COG2832	Protein of unknown function (DUF454)
H0904_RS12090	COG1444	tRNA N-acetyltransferase activity
H0904_RS12095	COG2707	UPF0756 membrane protein
H0904_RS12115	COG1122	ATPase activity
H0904_RS12120	COG1122	ATPase activity
H0904_RS12125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0904_RS12130	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H0904_RS12140	COG2716	regulation of RNA biosynthetic process
H0904_RS12145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0904_RS12150	COG0628	permease
H0904_RS12155	COG4783	chaperone-mediated protein folding
H0904_RS12160	COG1393	Belongs to the ArsC family
H0904_RS12165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0904_RS12170	COG2233	PERMEase
H0904_RS12175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0904_RS12180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0904_RS12185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0904_RS12190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0904_RS12195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0904_RS12205	COG2239	Acts as a magnesium transporter
H0904_RS12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0904_RS12220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0904_RS12225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0904_RS12230	COG2205	protein histidine kinase activity
H0904_RS12235	COG0745	RESPONSE REGULATOR receiver
H0904_RS12245	COG1597	lipid kinase activity
H0904_RS12255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H0904_RS12260	COG1328	CTP reductase activity
H0904_RS12270	COG1113	amino acid transport
H0904_RS12280	COG2207	Transcriptional regulator
H0904_RS12285	COG0561	phosphatase activity
H0904_RS12295	COG1115	amino acid carrier protein
H0904_RS12330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0904_RS12345	COG2226	methyltransferase
H0904_RS12360	COG0840	transmembrane signaling receptor activity
H0904_RS12380	COG0384	phenazine biosynthesis protein PhzF
H0904_RS12390	COG2315	Protein conserved in bacteria
H0904_RS12395	COG1396	sequence-specific DNA binding
H0904_RS12445	COG0538	isocitrate dehydrogenase activity
H0904_RS12450	COG1187	pseudouridine synthase activity
H0904_RS12460	COG0482	sulfurtransferase activity
H0904_RS12465	COG2915	High frequency lysogenization protein hflD homolog
H0904_RS12470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0904_RS12480	COG0745	RESPONSE REGULATOR receiver
H0904_RS12490	COG2850	peptidyl-arginine hydroxylation
H0904_RS12495	COG1280	lysine exporter protein (LysE YggA)
H0904_RS12505	COG0300	oxidoreductase activity
H0904_RS12515	COG2862	Uncharacterized protein family, UPF0114
H0904_RS12525	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0904_RS12530	COG1136	(ABC) transporter
H0904_RS12535	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0904_RS12540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0904_RS12550	COG1252	NADH dehydrogenase
H0904_RS12555	COG0737	Belongs to the 5'-nucleotidase family
H0904_RS12565	COG1472	Belongs to the glycosyl hydrolase 3 family
H0904_RS12570	COG0510	thiamine kinase activity
H0904_RS12575	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H0904_RS12585	COG0537	adenosine 5'-monophosphoramidase activity
H0904_RS12590	COG0084	hydrolase, TatD family'
H0904_RS12595	COG0470	DNA polymerase III
H0904_RS12600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H0904_RS12605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0904_RS12610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0904_RS12615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0904_RS12620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0904_RS12630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0904_RS12635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0904_RS12640	COG0416	fatty acid biosynthetic process
H0904_RS12645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0904_RS12650	COG1399	metal-binding, possibly nucleic acid-binding protein
H0904_RS12655	COG0424	maF-like protein
H0904_RS12660	COG0564	pseudouridine synthase activity
H0904_RS12665	COG1530	ribonuclease E activity
H0904_RS12665	COG1530	ribonuclease E activity
H0904_RS12680	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS12685	COG0243	molybdopterin cofactor binding
H0904_RS12695	COG2926	Belongs to the UPF0265 family
H0904_RS12700	COG2211	Major facilitator Superfamily
H0904_RS12705	COG2925	Exonuclease
H0904_RS12710	COG0277	FAD linked oxidase domain protein
H0904_RS12715	COG0531	amino acid
H0904_RS12725	COG4771	TonB-dependent receptor
H0904_RS12730	COG1120	ATPase activity
H0904_RS12735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0904_RS12745	COG0833	amino acid
H0904_RS12750	COG0583	DNA-binding transcription factor activity
H0904_RS12755	COG2855	membrane
H0904_RS12760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H0904_RS12765	COG1105	Belongs to the carbohydrate kinase PfkB family
H0904_RS12775	COG0814	amino acid
H0904_RS12780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0904_RS12795	COG0791	NLP P60 protein
H0904_RS12805	COG2814	Major facilitator Superfamily
H0904_RS12810	COG1187	pseudouridine synthase activity
H0904_RS12815	COG1061	Type III restriction enzyme res subunit
H0904_RS12820	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0904_RS12825	COG3081	Nucleoid-associated protein
H0904_RS12830	COG3082	Protein of unknown function (DUF1414)
H0904_RS12835	COG3083	sulfuric ester hydrolase activity
H0904_RS12850	COG2226	methyltransferase
H0904_RS12880	COG1335	isochorismatase
H0904_RS12895	COG0668	transmembrane transport
H0904_RS12900	COG0243	molybdopterin cofactor binding
H0904_RS12905	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS12910	COG3302	dmso reductase anchor subunit
H0904_RS12915	COG3381	protein complex oligomerization
H0904_RS12930	COG4770	biotin carboxylase activity
H0904_RS12940	COG4336	lyase activity
H0904_RS12945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H0904_RS12950	COG1914	H( )-stimulated, divalent metal cation uptake system
H0904_RS12960	COG1301	dicarboxylic acid transport
H0904_RS12965	COG1560	Kdo2-lipid A biosynthetic process
H0904_RS12985	COG2198	Histidine kinase
H0904_RS12985	COG0642	Histidine kinase
H0904_RS12995	COG0784	Response regulator, receiver
H0904_RS12995	COG2205	protein histidine kinase activity
H0904_RS13005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0904_RS13010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0904_RS13015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0904_RS13020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0904_RS13025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0904_RS13030	COG0814	amino acid
H0904_RS13035	COG5464	transposase or invertase
H0904_RS13055	COG1441	menaquinone biosynthetic process
H0904_RS13060	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H0904_RS13070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0904_RS13075	COG1169	isochorismate synthase
H0904_RS13090	COG1007	ATP synthesis coupled electron transport
H0904_RS13095	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0904_RS13100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0904_RS13105	COG0713	ATP synthesis coupled electron transport
H0904_RS13110	COG0839	Belongs to the complex I subunit 6 family
H0904_RS13115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0904_RS13120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H0904_RS13130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0904_RS13140	COG0649	NAD binding
H0904_RS13140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0904_RS13150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0904_RS13155	COG0583	DNA-binding transcription factor activity
H0904_RS13160	COG0436	Aminotransferase
H0904_RS13175	COG0471	metal ion transport
H0904_RS13175	COG0490	domain, Protein
H0904_RS13180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0904_RS13190	COG3501	Rhs element vgr protein
H0904_RS13215	COG3013	Belongs to the UPF0304 family
H0904_RS13220	COG3092	negative regulation of chromosome organization
H0904_RS13225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0904_RS13230	COG0857	belongs to the CobB CobQ family
H0904_RS13230	COG0280	phosphate acetyltransferase
H0904_RS13235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0904_RS13250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0904_RS13255	COG1090	epimerase
H0904_RS13270	COG3878	Protein conserved in bacteria
H0904_RS13275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0904_RS13280	COG1286	toxin biosynthetic process
H0904_RS13285	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H0904_RS13290	COG0285	dihydrofolate synthase activity
H0904_RS13295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0904_RS13300	COG0586	Pfam SNARE associated Golgi protein
H0904_RS13305	COG0101	tRNA pseudouridine synthase activity
H0904_RS13310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0904_RS13315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0904_RS13320	COG2207	Transcriptional regulator
H0904_RS13325	COG0697	spore germination
H0904_RS13345	COG0642	Histidine kinase
H0904_RS13380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0904_RS13385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H0904_RS13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0904_RS13400	COG3101	peptidyl-lysine hydroxylation
H0904_RS13405	COG0730	response to heat
H0904_RS13410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0904_RS13425	COG2986	histidine ammonia-lyase
H0904_RS13430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H0904_RS13440	COG1228	amidohydrolase
H0904_RS13445	COG2840	Smr protein MutS2
H0904_RS13450	COG2062	phosphohistidine phosphatase, SixA
H0904_RS13460	COG0183	Belongs to the thiolase family
H0904_RS13465	COG3691	Protein conserved in bacteria
H0904_RS13470	COG2067	long-chain fatty acid transport protein
H0904_RS13495	COG3722	fumarate hydratase activity
H0904_RS13505	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS13505	COG2213	PTS system mannitol-specific
H0904_RS13530	COG2072	flavoprotein involved in K transport
H0904_RS13535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0904_RS13540	COG2011	ABC-type metal ion transport system permease component
H0904_RS13550	COG1396	sequence-specific DNA binding
H0904_RS13580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0904_RS13595	COG3530	Putative quorum-sensing-regulated virulence factor
H0904_RS13605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0904_RS13610	COG3115	cell septum assembly
H0904_RS13625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS13630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0904_RS13635	COG2190	(PTS) system
H0904_RS13640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0904_RS13645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0904_RS13650	COG4208	sulfate ABC transporter
H0904_RS13660	COG4150	thiosulfate binding
H0904_RS13675	COG2837	iron assimilation
H0904_RS13685	COG0456	acetyltransferase
H0904_RS13690	COG0408	coproporphyrinogen oxidase activity
H0904_RS13700	COG1187	pseudouridine synthase activity
H0904_RS13710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0904_RS13715	COG2976	Protein conserved in bacteria
H0904_RS13720	COG0124	histidyl-tRNA synthetase
H0904_RS13735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H0904_RS13740	COG0105	UTP biosynthetic process
H0904_RS13745	COG4953	penicillin-binding protein 1C
H0904_RS13750	COG2373	Large extracellular alpha-helical protein
H0904_RS13760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H0904_RS13765	COG2975	iron-sulfur cluster assembly
H0904_RS13780	COG0633	Ferredoxin
H0904_RS13785	COG0443	Heat shock 70 kDa protein
H0904_RS13795	COG0316	Belongs to the HesB IscA family
H0904_RS13800	COG0822	iron-sulfur transferase activity
H0904_RS13805	COG1104	cysteine desulfurase activity
H0904_RS13810	COG1959	2 iron, 2 sulfur cluster binding
H0904_RS13815	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H0904_RS13820	COG0483	inositol monophosphate 1-phosphatase activity
H0904_RS13825	COG1063	alcohol dehydrogenase
H0904_RS13830	COG1802	Transcriptional regulator
H0904_RS13840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H0904_RS13850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H0904_RS13860	COG3121	Chaperone
H0904_RS13875	COG3121	Chaperone
H0904_RS13880	COG2814	Major facilitator Superfamily
H0904_RS13885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0904_RS13890	COG1017	nitric oxide dioxygenase activity
H0904_RS13890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0904_RS13895	COG0347	Belongs to the P(II) protein family
H0904_RS13900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0904_RS13900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0904_RS13905	COG2204	response regulator
H0904_RS13910	COG3170	Tfp pilus assembly protein FimV
H0904_RS13915	COG2205	protein histidine kinase activity
H0904_RS13935	COG2271	Major facilitator Superfamily
H0904_RS13940	COG1840	ABC-type Fe3 transport system, periplasmic component
H0904_RS13950	COG3842	ATPase activity
H0904_RS13985	COG0561	phosphatase activity
H0904_RS13990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H0904_RS13995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0904_RS13995	COG0047	phosphoribosylformylglycinamidine synthase activity
H0904_RS14000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H0904_RS14020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0904_RS14030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0904_RS14035	COG1381	Involved in DNA repair and RecF pathway recombination
H0904_RS14040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0904_RS14060	COG3086	response to oxidative stress
H0904_RS14080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H0904_RS14085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H0904_RS14100	COG0786	glutamate:sodium symporter activity
H0904_RS14105	COG0513	Belongs to the DEAD box helicase family
H0904_RS14120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0904_RS14125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0904_RS14130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0904_RS14135	COG0497	DNA recombination
H0904_RS14140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0904_RS14145	COG2914	Belongs to the UPF0125 (RnfH) family
H0904_RS14150	COG2867	negative regulation of translational initiation
H0904_RS14165	COG0582	viral genome integration into host DNA
H0904_RS14205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0904_RS14215	COG3311	Transcriptional regulator
H0904_RS14225	COG4983	Phage plasmid primase, P4 family domain protein
H0904_RS14230	COG3596	GTP binding
H0904_RS14315	COG2246	polysaccharide biosynthetic process
H0904_RS14350	COG0673	inositol 2-dehydrogenase activity
H0904_RS14360	COG0673	inositol 2-dehydrogenase activity
H0904_RS14365	COG2211	Major facilitator Superfamily
H0904_RS14390	COG1120	ATPase activity
H0904_RS14395	COG4774	siderophore transport
H0904_RS14405	COG1609	Transcriptional regulator
H0904_RS14410	COG2017	converts alpha-aldose to the beta-anomer
H0904_RS14415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H0904_RS14430	COG1414	Transcriptional regulator
H0904_RS14440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0904_RS14455	COG0702	epimerase
H0904_RS14460	COG4256	Hemin uptake protein
H0904_RS14470	COG3720	iron ion transport
H0904_RS14475	COG4558	Periplasmic binding protein
H0904_RS14480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0904_RS14485	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H0904_RS14515	COG3781	membrane
H0904_RS14535	COG0477	Major facilitator Superfamily
H0904_RS14540	COG3829	transcription factor binding
H0904_RS14545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H0904_RS14550	COG0372	Belongs to the citrate synthase family
H0904_RS14555	COG2079	MmgE PrpD family protein
H0904_RS14560	COG2017	converts alpha-aldose to the beta-anomer
H0904_RS14570	COG0589	response to stress
H0904_RS14615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0904_RS14625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0904_RS14630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0904_RS14640	COG0716	FMN binding
H0904_RS14650	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0904_RS14655	COG0354	folic acid binding
H0904_RS14670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0904_RS14670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0904_RS14675	COG0509	glycine decarboxylation via glycine cleavage system
H0904_RS14680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0904_RS14685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0904_RS14690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0904_RS14695	COG0006	proline dipeptidase activity
H0904_RS14700	COG3079	Belongs to the UPF0149 family
H0904_RS14705	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H0904_RS14715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0904_RS14720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0904_RS14725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0904_RS14730	COG0583	DNA-binding transcription factor activity
H0904_RS14740	COG1279	arginine transmembrane transporter activity
H0904_RS14745	COG0668	transmembrane transport
H0904_RS14750	COG3112	Uncharacterised protein family (UPF0231)
H0904_RS14800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0904_RS14805	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0904_RS14810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H0904_RS14815	COG2186	Transcriptional regulator
H0904_RS14825	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0904_RS14830	COG4969	Belongs to the N-Me-Phe pilin family
H0904_RS14835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0904_RS14845	COG0237	dephospho-CoA kinase activity
H0904_RS14850	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H0904_RS14860	COG0494	nUDIX hydrolase
H0904_RS14865	COG0653	protein targeting
H0904_RS14880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0904_RS14885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0904_RS14890	COG0849	cell division
H0904_RS14895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0904_RS14900	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0904_RS14905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0904_RS14910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0904_RS14915	COG0772	Belongs to the SEDS family
H0904_RS14920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0904_RS14925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0904_RS14930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0904_RS14935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0904_RS14940	COG0768	penicillin binding
H0904_RS14945	COG3116	cell division
H0904_RS14950	COG0275	rRNA processing
H0904_RS14955	COG2001	Belongs to the MraZ family
H0904_RS14970	COG0028	Belongs to the TPP enzyme family
H0904_RS14975	COG1022	Amp-dependent synthetase and ligase
H0904_RS14990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0904_RS15000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0904_RS15010	COG4533	DNA binding
H0904_RS15015	COG3066	DNA modification
H0904_RS15020	COG0861	Integral membrane protein TerC family
H0904_RS15040	COG0010	Belongs to the arginase family
H0904_RS15045	COG1166	arginine decarboxylase activity
H0904_RS15050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0904_RS15065	COG0640	Transcriptional regulator
H0904_RS15070	COG3091	SprT-like family
H0904_RS15075	COG2239	Acts as a magnesium transporter
H0904_RS15085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0904_RS15090	COG1151	hydroxylamine reductase activity
H0904_RS15115	COG2353	YceI-like domain
H0904_RS15120	COG3038	cytochrome b561
H0904_RS15145	COG3718	enzyme involved in inositol metabolism
H0904_RS15155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS15170	COG2814	Major facilitator Superfamily
H0904_RS15175	COG0673	inositol 2-dehydrogenase activity
H0904_RS15205	COG3708	Transcriptional regulator
H0904_RS15205	COG2207	Transcriptional regulator
H0904_RS15225	COG3088	subunit of a heme lyase
H0904_RS15225	COG4235	cytochrome complex assembly
H0904_RS15230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0904_RS15235	COG1138	Cytochrome C-type biogenesis protein
H0904_RS15245	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0904_RS15250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0904_RS15255	COG3005	denitrification pathway
H0904_RS15260	COG3043	anaerobic respiration
H0904_RS15265	COG0348	domain, Protein
H0904_RS15270	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS15280	COG3062	negative regulation of establishment of protein localization
H0904_RS15285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0904_RS15285	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0904_RS15295	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H0904_RS15300	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS15305	COG3301	Polysulphide reductase, NrfD
H0904_RS15310	COG1138	Cytochrome C-type biogenesis protein
H0904_RS15315	COG4235	cytochrome complex assembly
H0904_RS15325	COG0443	Heat shock 70 kDa protein
H0904_RS15335	COG0583	DNA-binding transcription factor activity
H0904_RS15355	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS15360	COG3302	dmso reductase anchor subunit
H0904_RS15365	COG3381	protein complex oligomerization
H0904_RS15370	COG0626	cystathionine gamma-synthase activity
H0904_RS15380	COG0626	cystathionine gamma-synthase activity
H0904_RS15390	COG1288	antiporter activity
H0904_RS15400	COG0513	Belongs to the DEAD box helicase family
H0904_RS15410	COG0583	DNA-binding transcription factor activity
H0904_RS15415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0904_RS15420	COG0402	S-adenosylhomocysteine deaminase activity
H0904_RS15425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0904_RS15430	COG0784	Response regulator, receiver
H0904_RS15430	COG2198	Histidine kinase
H0904_RS15430	COG2205	protein histidine kinase activity
H0904_RS15435	COG1879	ABC-type sugar transport system periplasmic component
H0904_RS15440	COG0745	RESPONSE REGULATOR receiver
H0904_RS15445	COG3005	denitrification pathway
H0904_RS15505	COG1473	amidohydrolase
H0904_RS15540	COG3539	Fimbrial protein
H0904_RS15560	COG2197	response regulator
H0904_RS15575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H0904_RS15580	COG0640	Transcriptional regulator
H0904_RS15760	COG0582	viral genome integration into host DNA
H0904_RS15930	COG5410	chromosome segregation
H0904_RS16110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0904_RS16115	COG3723	Recombinational DNA repair protein, rece pathway
H0904_RS16180	COG0582	viral genome integration into host DNA
H0904_RS16190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0904_RS16195	COG2501	S4 domain
H0904_RS16200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS16200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS16205	COG1105	Belongs to the carbohydrate kinase PfkB family
H0904_RS16210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0904_RS16210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0904_RS16210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0904_RS16220	COG0215	cysteine-tRNA ligase activity
H0904_RS16225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0904_RS16230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0904_RS16235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0904_RS16240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0904_RS16255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0904_RS16260	COG4181	ATPase activity
H0904_RS16265	COG2755	lipolytic protein G-D-S-L family
H0904_RS16270	COG0300	oxidoreductase activity
H0904_RS16275	COG3118	belongs to the thioredoxin family
H0904_RS16280	COG0330	HflC and HflK could
H0904_RS16285	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0904_RS16295	COG2217	Heavy metal translocating P-type atpase
H0904_RS16300	COG3247	response to pH
H0904_RS16305	COG3735	TraB family
H0904_RS16310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0904_RS16315	COG0737	Belongs to the 5'-nucleotidase family
H0904_RS16320	COG2223	nitrite transmembrane transporter activity
H0904_RS16325	COG4651	solute:proton antiporter activity
H0904_RS16325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0904_RS16335	COG1349	DNA-binding transcription factor activity
H0904_RS16350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0904_RS16355	COG3192	ethanolamine utilization protein
H0904_RS16360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS16375	COG0563	adenylate kinase activity
H0904_RS16380	COG0326	Molecular chaperone. Has ATPase activity
H0904_RS16385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0904_RS16390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0904_RS16395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0904_RS16400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0904_RS16415	COG3264	Mechanosensitive ion channel
H0904_RS16415	COG1196	nuclear chromosome segregation
H0904_RS16420	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0904_RS16425	COG1309	transcriptional regulator
H0904_RS16430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0904_RS16435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0904_RS16445	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
H0904_RS16445	COG3210	domain, Protein
H0904_RS16445	COG3064	Membrane
H0904_RS16450	COG0471	metal ion transport
H0904_RS16460	COG0148	phosphopyruvate hydratase activity
H0904_RS16465	COG0504	CTP synthase activity
H0904_RS16470	COG3956	TIGRFAM MazG family protein
H0904_RS16475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0904_RS16480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0904_RS16490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0904_RS16505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0904_RS16510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0904_RS16515	COG1643	Atp-dependent helicase
H0904_RS16520	COG1489	DNA binding
H0904_RS16535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0904_RS16540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H0904_RS16545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0904_RS16550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0904_RS16555	COG0288	reversible hydration of carbon dioxide
H0904_RS16560	COG1131	(ABC) transporter
H0904_RS16565	COG0842	Transport permease protein
H0904_RS16575	COG3121	Chaperone
H0904_RS16605	COG2132	Multicopper oxidase
H0904_RS16625	COG5441	Belongs to the UPF0261 family
H0904_RS16630	COG5564	TIM-barrel signal transduction protein
H0904_RS16640	COG0673	inositol 2-dehydrogenase activity
H0904_RS16645	COG0534	Mate efflux family protein
H0904_RS16655	COG0523	cobalamin synthesis protein
H0904_RS16660	COG2879	small protein
H0904_RS16665	COG1966	Carbon starvation protein
H0904_RS16695	COG3778	Protein conserved in bacteria
H0904_RS16705	COG4381	Mu-like prophage protein gp46
H0904_RS16710	COG4384	Bacteriophage Mu Gp45 protein
H0904_RS16720	COG4228	DNA circulation
H0904_RS16730	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
H0904_RS16740	COG4386	tail sheath protein
H0904_RS16750	COG5003	unkown
H0904_RS16755	COG4387	Mu-like prophage protein GP36
H0904_RS16765	COG4397	Mu-like prophage major head subunit gpT
H0904_RS16770	COG4388	Caudovirus prohead serine protease
H0904_RS16775	COG5005	Phage virion morphogenesis
H0904_RS16780	COG2369	cell adhesion
H0904_RS16785	COG4383	Mu-like prophage protein gp29
H0904_RS16790	COG4373	Mu-like prophage FluMu protein gp28
H0904_RS16800	COG0640	Transcriptional regulator
H0904_RS16840	COG5566	PFAM Mor transcription activator
H0904_RS16880	COG2842	Transposition protein
H0904_RS16885	COG2801	Transposase and inactivated derivatives
H0904_RS16890	COG3423	Transcriptional regulator
H0904_RS16905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS16920	COG4566	intracellular signal transduction
H0904_RS16930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0904_RS16960	COG4633	Protein conserved in bacteria
H0904_RS16990	COG0583	DNA-binding transcription factor activity
H0904_RS17000	COG2252	PERMEase
H0904_RS17015	COG0786	glutamate:sodium symporter activity
H0904_RS17020	COG0583	DNA-binding transcription factor activity
H0904_RS17030	COG0251	oxidation-reduction process
H0904_RS17035	COG3961	Belongs to the TPP enzyme family
H0904_RS17060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0904_RS17060	COG2010	Cytochrome c
H0904_RS17075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0904_RS17075	COG2010	Cytochrome c
H0904_RS17080	COG2080	2 iron, 2 sulfur cluster binding
H0904_RS17085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0904_RS17085	COG2010	Cytochrome c
H0904_RS17090	COG2010	Cytochrome c
H0904_RS17090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0904_RS17095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0904_RS17110	COG1388	LysM domain
H0904_RS17110	COG4942	peptidase
H0904_RS17115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0904_RS17120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0904_RS17125	COG0585	pseudouridine synthase activity
H0904_RS17130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H0904_RS17135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H0904_RS17140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H0904_RS17145	COG0529	Catalyzes the synthesis of activated sulfate
H0904_RS17150	COG2895	sulfate adenylyltransferase (ATP) activity
H0904_RS17155	COG0175	sulfate reduction
H0904_RS17160	COG1648	precorrin-2 dehydrogenase activity
H0904_RS17160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0904_RS17170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0904_RS17175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0904_RS17180	COG0720	synthase
H0904_RS17185	COG3477	response to acidic pH
H0904_RS17190	COG0602	queuosine metabolic process
H0904_RS17225	COG3021	interspecies interaction between organisms
H0904_RS17255	COG0542	response to heat
H0904_RS17265	COG0564	pseudouridine synthase activity
H0904_RS17270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0904_RS17275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0904_RS17280	COG0077	Prephenate dehydratase
H0904_RS17280	COG1605	Chorismate mutase
H0904_RS17285	COG0840	transmembrane signaling receptor activity
H0904_RS17290	COG0287	Prephenate dehydrogenase
H0904_RS17290	COG1605	Chorismate mutase
H0904_RS17295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0904_RS17300	COG0335	large ribosomal subunit rRNA binding
H0904_RS17305	COG0336	Belongs to the RNA methyltransferase TrmD family
H0904_RS17315	COG0228	four-way junction DNA binding
H0904_RS17320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0904_RS17325	COG4137	Cytochrome C assembly protein
H0904_RS17330	COG4536	flavin adenine dinucleotide binding
H0904_RS17335	COG1854	S-ribosylhomocysteine lyase activity
H0904_RS17340	COG2918	glutathione biosynthetic process
H0904_RS17365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H0904_RS17370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0904_RS17375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0904_RS17380	COG1546	Belongs to the CinA family
H0904_RS17385	COG2814	Major facilitator Superfamily
H0904_RS17390	COG0318	PFAM AMP-dependent synthetase and ligase
H0904_RS17390	COG0204	Acyl-transferase
H0904_RS17395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0904_RS17400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0904_RS17405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0904_RS17425	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H0904_RS17430	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0904_RS17435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0904_RS17450	COG2991	Protein conserved in bacteria
H0904_RS17455	COG1477	protein flavinylation
H0904_RS17460	COG2871	sodium ion transport
H0904_RS17465	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0904_RS17470	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0904_RS17475	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0904_RS17480	COG1805	sodium ion transport
H0904_RS17485	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0904_RS17490	COG3034	peptidoglycan biosynthetic process
H0904_RS17495	COG0121	glutamine amidotransferase
H0904_RS17505	COG1960	acyl-CoA dehydrogenase activity
H0904_RS17530	COG0583	DNA-binding transcription factor activity
H0904_RS17535	COG0583	DNA-binding transcription factor activity
H0904_RS17555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0904_RS17560	COG0189	ligase activity
H0904_RS17565	COG1678	Uncharacterized ACR, COG1678
H0904_RS17570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0904_RS17575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0904_RS17580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H0904_RS17585	COG0762	integral membrane protein
H0904_RS17590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0904_RS17595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0904_RS17600	COG4607	ABC-type enterochelin transport system periplasmic component
H0904_RS17610	COG2066	Belongs to the glutaminase family
H0904_RS17615	COG3171	Protein conserved in bacteria
H0904_RS17625	COG1194	a g-specific adenine glycosylase
H0904_RS17630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H0904_RS17635	COG0741	lytic transglycosylase activity
H0904_RS17645	COG0582	viral genome integration into host DNA
H0904_RS17690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0904_RS17695	COG0489	protein tyrosine kinase activity
H0904_RS17695	COG3206	protein involved in exopolysaccharide biosynthesis
H0904_RS17700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0904_RS17710	COG2801	Transposase and inactivated derivatives
H0904_RS17715	COG0438	transferase activity, transferring glycosyl groups
H0904_RS17760	COG4735	regulation of single-species biofilm formation
H0904_RS17765	COG2378	regulation of single-species biofilm formation
H0904_RS17790	COG2003	Belongs to the UPF0758 family
H0904_RS17805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H0904_RS17810	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H0904_RS17820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0904_RS17825	COG2731	YhcH YjgK YiaL family protein
H0904_RS17830	COG1737	Transcriptional regulator
H0904_RS17845	COG0500	methyltransferase
H0904_RS17860	COG2197	response regulator
H0904_RS17875	COG3188	usher protein
H0904_RS17900	COG3188	usher protein
H0904_RS17905	COG3121	Chaperone
H0904_RS17920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H0904_RS17935	COG2207	Transcriptional regulator
H0904_RS17935	COG3708	Transcriptional regulator
H0904_RS17945	COG3609	addiction module antidote protein, CC2985 family
H0904_RS17950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0904_RS17950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0904_RS17970	COG4869	propanediol catabolic process
H0904_RS17980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H0904_RS17985	COG1882	Formate acetyltransferase
H0904_RS18000	COG1454	alcohol dehydrogenase
H0904_RS18000	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS18025	COG0745	RESPONSE REGULATOR receiver
H0904_RS18045	COG1177	transmembrane transport
H0904_RS18060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0904_RS18060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0904_RS18075	COG3121	Chaperone
H0904_RS18080	COG3188	usher protein
H0904_RS18100	COG0583	DNA-binding transcription factor activity
H0904_RS18120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0904_RS18125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0904_RS18150	COG3239	Fatty acid desaturase
H0904_RS18155	COG0726	polysaccharide deacetylase
H0904_RS18165	COG2271	Major facilitator Superfamily
H0904_RS18180	COG2721	sulfolactate sulfo-lyase activity
H0904_RS18195	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS18195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS18205	COG3716	PTS system mannose fructose sorbose family IID component
H0904_RS18220	COG1349	DNA-binding transcription factor activity
H0904_RS18230	COG1129	ABC transporter
H0904_RS18235	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0904_RS18240	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0904_RS18245	COG3623	hexulose-6-phosphate isomerase
H0904_RS18250	COG1070	Carbohydrate kinase
H0904_RS18255	COG2194	sulfuric ester hydrolase activity
H0904_RS18265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS18270	COG2814	Major facilitator Superfamily
H0904_RS18275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0904_RS18285	COG1609	Transcriptional regulator
H0904_RS18290	COG0583	DNA-binding transcription factor activity
H0904_RS18295	COG2610	gluconate transmembrane transporter activity
H0904_RS18300	COG3048	D-serine ammonia-lyase activity
H0904_RS18305	COG1363	Peptidase, m42
H0904_RS18310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0904_RS18320	COG0444	Belongs to the ABC transporter superfamily
H0904_RS18330	COG0747	negative chemotaxis
H0904_RS18340	COG3573	Dehydrogenase
H0904_RS18355	COG4604	ABC transporter, ATP-binding protein
H0904_RS18360	COG4605	iron ion homeostasis
H0904_RS18365	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0904_RS18370	COG4607	ABC-type enterochelin transport system periplasmic component
H0904_RS18405	COG3121	Chaperone
H0904_RS18410	COG3188	usher protein
H0904_RS18425	COG3835	regulator
H0904_RS18430	COG1929	Belongs to the glycerate kinase type-1 family
H0904_RS18435	COG2271	Major facilitator Superfamily
H0904_RS18445	COG1063	alcohol dehydrogenase
H0904_RS18450	COG1830	Aldolase
H0904_RS18455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0904_RS18475	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H0904_RS18480	COG0800	Aldolase
H0904_RS18490	COG1414	Transcriptional regulator
H0904_RS18495	COG2181	nitrate reductase activity
H0904_RS18500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H0904_RS18505	COG1140	nitrate reductase beta subunit
H0904_RS18510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H0904_RS18515	COG2223	nitrite transmembrane transporter activity
H0904_RS18520	COG3850	Histidine kinase
H0904_RS18525	COG2197	response regulator
H0904_RS18530	COG3835	regulator
H0904_RS18535	COG1929	Belongs to the glycerate kinase type-1 family
H0904_RS18545	COG0183	Belongs to the thiolase family
H0904_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS18560	COG0318	PFAM AMP-dependent synthetase and ligase
H0904_RS18565	COG0625	glutathione transferase activity
H0904_RS18575	COG1840	ABC-type Fe3 transport system, periplasmic component
H0904_RS18580	COG3842	ATPase activity
H0904_RS18585	COG0318	PFAM AMP-dependent synthetase and ligase
H0904_RS18585	COG0204	Acyl-transferase
H0904_RS18590	COG1858	cytochrome C peroxidase
H0904_RS18595	COG2211	Major facilitator Superfamily
H0904_RS18600	COG1397	ADP-ribosylglycohydrolase
H0904_RS18605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0904_RS18610	COG2188	Transcriptional regulator
H0904_RS18625	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS18630	COG0243	molybdopterin cofactor binding
H0904_RS18650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0904_RS18655	COG1538	Outer membrane efflux protein
H0904_RS18660	COG0577	efflux transmembrane transporter activity
H0904_RS18660	COG1136	(ABC) transporter
H0904_RS18665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0904_RS18670	COG1132	(ABC) transporter
H0904_RS18700	COG3539	Fimbrial protein
H0904_RS18710	COG3121	Chaperone
H0904_RS18715	COG3188	usher protein
H0904_RS18725	COG3539	Fimbrial protein
H0904_RS18745	COG2205	protein histidine kinase activity
H0904_RS18750	COG0745	RESPONSE REGULATOR receiver
H0904_RS18755	COG0582	viral genome integration into host DNA
H0904_RS18770	COG0582	viral genome integration into host DNA
H0904_RS18780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0904_RS18795	COG0795	lipopolysaccharide-transporting ATPase activity
H0904_RS18800	COG0795	lipopolysaccharide-transporting ATPase activity
H0904_RS18805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H0904_RS18810	COG2927	DNA polymerase III (CHI subunit)
H0904_RS18815	COG0525	valine-tRNA ligase activity
H0904_RS18830	COG1285	pathogenesis
H0904_RS18835	COG2211	Major facilitator Superfamily
H0904_RS18845	COG1609	Transcriptional regulator
H0904_RS18850	COG1085	galactose-1-phosphate uridylyltransferase
H0904_RS18855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0904_RS18875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H0904_RS18880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0904_RS18890	COG2188	Transcriptional regulator
H0904_RS18920	COG0540	Belongs to the ATCase OTCase family
H0904_RS18925	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H0904_RS18930	COG0251	oxidation-reduction process
H0904_RS18935	COG1328	CTP reductase activity
H0904_RS18940	COG0602	queuosine metabolic process
H0904_RS18945	COG3787	Belongs to the UPF0306 family
H0904_RS18955	COG2827	Endonuclease containing a URI domain
H0904_RS18960	COG3153	acetyltransferase
H0904_RS18965	COG3154	lipid carrier protein
H0904_RS18970	COG0826	peptidase U32
H0904_RS18975	COG0826	peptidase U32
H0904_RS18985	COG3077	Addiction module antitoxin, RelB DinJ family
H0904_RS19005	COG3275	phosphorelay sensor kinase activity
H0904_RS19025	COG0513	Belongs to the DEAD box helicase family
H0904_RS19045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0904_RS19050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0904_RS19055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0904_RS19060	COG0195	Participates in both transcription termination and antitermination
H0904_RS19065	COG0779	Required for maturation of 30S ribosomal subunits
H0904_RS19080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0904_RS19085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0904_RS19090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0904_RS19095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0904_RS19100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H0904_RS19105	COG1534	Rna-binding protein
H0904_RS19115	COG2027	D-alanyl-D-alanine carboxypeptidase
H0904_RS19120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0904_RS19125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0904_RS19130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0904_RS19135	COG0142	geranyltranstransferase activity
H0904_RS19150	COG3423	Transcriptional regulator
H0904_RS19155	COG0039	L-malate dehydrogenase activity
H0904_RS19160	COG1438	arginine binding
H0904_RS19170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0904_RS19175	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0904_RS19185	COG2105	PFAM AIG2 family protein
H0904_RS19190	COG2911	Protein conserved in bacteria
H0904_RS19195	COG0729	surface antigen
H0904_RS19200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0904_RS19205	COG1253	flavin adenine dinucleotide binding
H0904_RS19215	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H0904_RS19220	COG0642	Histidine kinase
H0904_RS19230	COG3111	PFAM Bacterial OB fold (BOF) protein
H0904_RS19235	COG0494	nUDIX hydrolase
H0904_RS19245	COG0579	oxidoreductase
H0904_RS19255	COG0545	Peptidyl-prolyl cis-trans isomerase
H0904_RS19260	COG3061	Opacity-associated protein A
H0904_RS19270	COG0359	binds to the 23S rRNA
H0904_RS19275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0904_RS19280	COG2965	DNA replication, synthesis of RNA primer
H0904_RS19285	COG0360	Binds together with S18 to 16S ribosomal RNA
H0904_RS19290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0904_RS19295	COG0557	exoribonuclease II activity
H0904_RS19300	COG1959	2 iron, 2 sulfur cluster binding
H0904_RS19305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0904_RS19310	COG0330	HflC and HflK could
H0904_RS19315	COG0330	HflC and HflK could
H0904_RS19320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0904_RS19325	COG1923	regulation of RNA biosynthetic process
H0904_RS19330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0904_RS19335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0904_RS19340	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0904_RS19345	COG0802	atpase or kinase
H0904_RS19350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0904_RS19375	COG1162	GTPase activity
H0904_RS19380	COG0688	phosphatidylethanolamine metabolic process
H0904_RS19385	COG1511	domain protein
H0904_RS19385	COG3264	Mechanosensitive ion channel
H0904_RS19400	COG0561	phosphatase activity
H0904_RS19405	COG2267	carboxylic ester hydrolase activity
H0904_RS19420	COG2050	protein possibly involved in aromatic compounds catabolism
H0904_RS19430	COG0531	amino acid
H0904_RS19445	COG1690	Belongs to the RtcB family
H0904_RS19450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0904_RS19470	COG0210	DNA helicase
H0904_RS19475	COG1011	Hydrolase
H0904_RS19490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0904_RS19495	COG5567	small periplasmic lipoprotein
H0904_RS19500	COG1965	Belongs to the frataxin family
H0904_RS19520	COG2959	enzyme of heme biosynthesis
H0904_RS19525	COG3071	HemY protein
H0904_RS19560	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H0904_RS19570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0904_RS19575	COG2244	polysaccharide biosynthetic process
H0904_RS19580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0904_RS19590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0904_RS19595	COG1088	dTDP-glucose 4,6-dehydratase activity
H0904_RS19600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0904_RS19605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0904_RS19610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H0904_RS19615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0904_RS19620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H0904_RS19625	COG3118	belongs to the thioredoxin family
H0904_RS19630	COG0513	Belongs to the DEAD box helicase family
H0904_RS19635	COG0248	Ppx GppA phosphatase
H0904_RS19640	COG0210	DNA helicase
H0904_RS19645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0904_RS19660	COG0129	dihydroxy-acid dehydratase activity
H0904_RS19690	COG3085	chromosome segregation
H0904_RS19695	COG0583	DNA-binding transcription factor activity
H0904_RS19730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0904_RS19740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0904_RS19745	COG0009	L-threonylcarbamoyladenylate synthase
H0904_RS19750	COG0551	DNA topoisomerase type I activity
H0904_RS19755	COG0758	DNA mediated transformation
H0904_RS19765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0904_RS19775	COG0569	domain protein
H0904_RS19785	COG3036	rescue of stalled ribosome
H0904_RS19790	COG0789	Transcriptional regulator
H0904_RS19805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0904_RS19815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0904_RS19820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0904_RS19825	COG0201	protein transport
H0904_RS19830	COG0200	Binds to the 23S rRNA
H0904_RS19835	COG1841	ribosomal large subunit assembly
H0904_RS19840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0904_RS19845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0904_RS19850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0904_RS19855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0904_RS19860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0904_RS19865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0904_RS19870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0904_RS19875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0904_RS19880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0904_RS19890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0904_RS19900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0904_RS19910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0904_RS19915	COG0089	rRNA binding
H0904_RS19920	COG0088	Forms part of the polypeptide exit tunnel
H0904_RS19925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0904_RS19930	COG0051	transcription antitermination factor activity, RNA binding
H0904_RS19970	COG1072	(Pantothenic acid kinase))
H0904_RS19980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0904_RS20020	COG0138	bifunctional purine biosynthesis protein purh
H0904_RS20025	COG0151	Belongs to the GarS family
H0904_RS20040	COG3068	Protein conserved in bacteria
H0904_RS20045	COG1515	deoxyribonuclease V activity
H0904_RS20050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H0904_RS20055	COG2816	NAD+ diphosphatase activity
H0904_RS20075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0904_RS20080	COG3842	ATPase activity
H0904_RS20090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0904_RS20100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0904_RS20105	COG2104	thiamine diphosphate biosynthetic process
H0904_RS20110	COG2022	thiamine diphosphate biosynthetic process
H0904_RS20125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0904_RS20140	COG2233	PERMEase
H0904_RS20160	COG3119	arylsulfatase activity
H0904_RS20165	COG0641	radical SAM
H0904_RS20170	COG1349	DNA-binding transcription factor activity
H0904_RS20180	COG2222	sugar isomerase
H0904_RS20185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS20190	COG3715	PTS system
H0904_RS20195	COG3716	PTS system mannose fructose sorbose family IID component
H0904_RS20200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS20200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0904_RS20205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H0904_RS20215	COG1028	Short-chain dehydrogenase reductase Sdr
H0904_RS20230	COG3119	arylsulfatase activity
H0904_RS20235	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0904_RS20240	COG3069	C4-dicarboxylate transmembrane transporter activity
H0904_RS20250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0904_RS20255	COG0085	RNA polymerase activity
H0904_RS20260	COG0222	ribosome binding
H0904_RS20265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0904_RS20275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0904_RS20280	COG0250	Participates in transcription elongation, termination and antitermination
H0904_RS20285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0904_RS20300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0904_RS20305	COG0049	tRNA binding
H0904_RS20310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0904_RS20315	COG2168	tRNA wobble position uridine thiolation
H0904_RS20320	COG2923	Belongs to the DsrF TusC family
H0904_RS20325	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0904_RS20330	COG2964	Protein conserved in bacteria
H0904_RS20335	COG0545	Peptidyl-prolyl cis-trans isomerase
H0904_RS20340	COG2900	Belongs to the SlyX family
H0904_RS20345	COG1047	Peptidyl-prolyl cis-trans
H0904_RS20350	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0904_RS20360	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0904_RS20365	COG0488	(ABC) transporter
H0904_RS20370	COG1982	Orn Lys Arg decarboxylase major
H0904_RS20380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H0904_RS20385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0904_RS20385	COG1263	PTS System
H0904_RS20405	COG0429	hydrolase of the alpha beta-hydrolase fold
H0904_RS20410	COG3089	Belongs to the UPF0270 family
H0904_RS20415	COG3954	Phosphoribulokinase
H0904_RS20420	COG1765	OsmC-like protein
H0904_RS20425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0904_RS20455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0904_RS20460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0904_RS20460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0904_RS20465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0904_RS20470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0904_RS20475	COG3084	Protein conserved in bacteria
H0904_RS20480	COG0746	molybdenum cofactor guanylyltransferase activity
H0904_RS20485	COG1763	Mo-molybdopterin cofactor biosynthetic process
H0904_RS20500	COG2723	6-phospho-beta-galactosidase activity
H0904_RS20510	COG2378	regulation of single-species biofilm formation
H0904_RS20520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0904_RS20525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0904_RS20535	COG1295	ribonuclease BN
H0904_RS20545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0904_RS20550	COG0612	Peptidase, M16
H0904_RS20560	COG4608	Belongs to the ABC transporter superfamily
H0904_RS20565	COG0444	Belongs to the ABC transporter superfamily
H0904_RS20570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0904_RS20575	COG0601	transmembrane transport
H0904_RS20580	COG0747	negative chemotaxis
H0904_RS20585	COG2831	hemolysin activation secretion protein
H0904_RS20595	COG0751	glycine-tRNA ligase activity
H0904_RS20605	COG2818	Glycosylase
H0904_RS20610	COG3977	Valine--pyruvate aminotransferase
H0904_RS20620	COG5645	(Lipo)protein
H0904_RS20625	COG0823	Involved in the tonB-independent uptake of proteins
H0904_RS20630	COG2860	membrane
H0904_RS20635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0904_RS20645	COG1758	RNA polymerase activity
H0904_RS20650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0904_RS20655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0904_RS20660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0904_RS20665	COG0786	glutamate:sodium symporter activity
H0904_RS20670	COG2233	PERMEase
H0904_RS20675	COG2982	Protein involved in outer membrane biogenesis
H0904_RS20680	COG0456	acetyltransferase
H0904_RS20690	COG1011	Hydrolase
H0904_RS20705	COG1695	Transcriptional regulator
H0904_RS20740	COG3539	Fimbrial protein
H0904_RS20785	COG3539	Fimbrial protein
H0904_RS20820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0904_RS20825	COG3078	GTPase activator activity
H0904_RS20830	COG2252	PERMEase
H0904_RS20835	COG0765	amino acid transport
H0904_RS20845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0904_RS20850	COG0704	Plays a role in the regulation of phosphate uptake
H0904_RS20860	COG0581	inorganic phosphate transmembrane transporter activity
H0904_RS20865	COG0573	inorganic phosphate transmembrane transporter activity
H0904_RS20870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0904_RS20875	COG2205	protein histidine kinase activity
H0904_RS20880	COG0745	RESPONSE REGULATOR receiver
H0904_RS20885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0904_RS20890	COG2183	response to ionizing radiation
H0904_RS20895	COG1918	ferrous iron import across plasma membrane
H0904_RS20910	COG2267	carboxylic ester hydrolase activity
H0904_RS20920	COG0316	Belongs to the HesB IscA family
H0904_RS20920	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H0904_RS20925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0904_RS20930	COG0705	Rhomboid family
H0904_RS20935	COG1349	DNA-binding transcription factor activity
H0904_RS20940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0904_RS20955	COG3189	MarR family transcriptional regulator
H0904_RS20965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H0904_RS20970	COG0028	Belongs to the TPP enzyme family
H0904_RS20975	COG0477	Major facilitator Superfamily
H0904_RS20990	COG2226	methyltransferase
H0904_RS20995	COG2030	dehydratase
H0904_RS20995	COG1012	belongs to the aldehyde dehydrogenase family
H0904_RS21000	COG3396	Phenylacetate-CoA oxygenase
H0904_RS21005	COG3460	Phenylacetate-CoA oxygenase
H0904_RS21010	COG3396	Phenylacetate-CoA oxygenase
H0904_RS21015	COG2151	metal-sulfur cluster biosynthetic enzyme
H0904_RS21020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0904_RS21025	COG1024	Enoyl-CoA hydratase
H0904_RS21030	COG1024	Enoyl-CoA hydratase
H0904_RS21035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0904_RS21040	COG2050	protein possibly involved in aromatic compounds catabolism
H0904_RS21045	COG0183	Belongs to the thiolase family
H0904_RS21050	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0904_RS21055	COG3327	negative regulation of DNA-templated transcription, initiation
H0904_RS21060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0904_RS21065	COG2814	Major facilitator Superfamily
H0904_RS21070	COG1566	PFAM secretion protein HlyD family protein
H0904_RS21075	COG4771	TonB-dependent receptor
H0904_RS21080	COG2819	hydrolase of the alpha beta superfamily
H0904_RS21085	COG0583	DNA-binding transcription factor activity
H0904_RS21090	COG0666	response to abiotic stimulus
H0904_RS21100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0904_RS21105	COG1304	FMN binding
H0904_RS21115	COG0549	Belongs to the carbamate kinase family
H0904_RS21120	COG0402	S-adenosylhomocysteine deaminase activity
H0904_RS21135	COG0477	Major facilitator Superfamily
H0904_RS21140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0904_RS21220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0904_RS21235	COG1368	sulfuric ester hydrolase activity
H0904_RS21240	COG3276	selenocysteine insertion sequence binding
H0904_RS21245	COG1921	L-seryl-tRNASec selenium transferase activity
H0904_RS21250	COG3058	Necessary for formate dehydrogenase activity
H0904_RS21270	COG1312	Catalyzes the dehydration of D-mannonate
H0904_RS21275	COG2186	Transcriptional regulator
H0904_RS21280	COG4948	Mandelate Racemase Muconate Lactonizing
H0904_RS21285	COG1063	alcohol dehydrogenase
H0904_RS21290	COG0477	Major facilitator Superfamily
H0904_RS21295	COG0246	Mannitol dehydrogenase
H0904_RS21310	COG0679	Auxin Efflux Carrier
H0904_RS21315	COG0028	Belongs to the TPP enzyme family
H0904_RS21325	COG2864	formate dehydrogenase
H0904_RS21330	COG0437	4 iron, 4 sulfur cluster binding
H0904_RS21340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0904_RS21345	COG3550	peptidyl-serine autophosphorylation
H0904_RS21355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0904_RS21360	COG0706	membrane insertase activity
H0904_RS21365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0904_RS21370	COG0594	ribonuclease P activity
H0904_RS21375	COG0230	Belongs to the bacterial ribosomal protein bL34 family