locus-tag	class	description
H9X60_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9X60_RS00010	COG0592	DNA-directed DNA polymerase activity
H9X60_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9X60_RS00020	COG0187	DNA topoisomerase II activity
H9X60_RS00030	COG2194	sulfuric ester hydrolase activity
H9X60_RS00040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9X60_RS00045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9X60_RS00050	COG0254	rRNA binding
H9X60_RS00055	COG1940	carbohydrate kinase activity
H9X60_RS00110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9X60_RS00115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9X60_RS00120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9X60_RS00125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9X60_RS00130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9X60_RS00135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9X60_RS00140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9X60_RS00155	COG0356	it plays a direct role in the translocation of protons across the membrane
H9X60_RS00160	COG3312	ion transport
H9X60_RS00165	COG0357	Ribosomal RNA small subunit methyltransferase G
H9X60_RS00170	COG0445	tRNA wobble uridine modification
H9X60_RS00175	COG0716	FMN binding
H9X60_RS00180	COG1522	sequence-specific DNA binding
H9X60_RS00185	COG2502	aspartate--ammonia ligase
H9X60_RS00190	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H9X60_RS00195	COG0714	Associated with various cellular activities
H9X60_RS00205	COG1129	ABC transporter
H9X60_RS00210	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9X60_RS00220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS00225	COG1609	Transcriptional regulator
H9X60_RS00230	COG0477	Major facilitator Superfamily
H9X60_RS00235	COG2186	Transcriptional regulator
H9X60_RS00270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9X60_RS00275	COG3162	membrane
H9X60_RS00280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9X60_RS00285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H9X60_RS00290	COG0443	Heat shock 70 kDa protein
H9X60_RS00300	COG2258	MOSC domain
H9X60_RS00315	COG1335	isochorismatase
H9X60_RS00320	COG0180	Tryptophanyl-tRNA synthetase
H9X60_RS00325	COG0546	phosphoglycolate phosphatase activity
H9X60_RS00330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9X60_RS00345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9X60_RS00350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9X60_RS00355	COG4796	Type ii and iii secretion system protein
H9X60_RS00375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9X60_RS00380	COG0494	nUDIX hydrolase
H9X60_RS00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9X60_RS00395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9X60_RS00400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9X60_RS00405	COG1741	Belongs to the pirin family
H9X60_RS00410	COG2081	HI0933 family
H9X60_RS00415	COG0306	phosphate transporter
H9X60_RS00425	COG0589	response to stress
H9X60_RS00430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9X60_RS00435	COG0742	ribosomal rna small subunit methyltransferase
H9X60_RS00450	COG0582	viral genome integration into host DNA
H9X60_RS00460	COG1196	nuclear chromosome segregation
H9X60_RS00465	COG0732	type I restriction modification DNA specificity domain
H9X60_RS00470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9X60_RS00480	COG3210	domain, Protein
H9X60_RS00480	COG3210	domain, Protein
H9X60_RS00485	COG2831	hemolysin activation secretion protein
H9X60_RS00510	COG4735	regulation of single-species biofilm formation
H9X60_RS00515	COG2378	regulation of single-species biofilm formation
H9X60_RS00575	COG0582	viral genome integration into host DNA
H9X60_RS00595	COG3188	usher protein
H9X60_RS00600	COG3121	Chaperone
H9X60_RS00620	COG3122	Protein conserved in bacteria
H9X60_RS00630	COG1278	Cold shock
H9X60_RS00635	COG1737	Transcriptional regulator
H9X60_RS00640	COG1263	PTS System
H9X60_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS00645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9X60_RS00815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9X60_RS00820	COG0477	Major facilitator Superfamily
H9X60_RS00835	COG0402	S-adenosylhomocysteine deaminase activity
H9X60_RS00840	COG0549	Belongs to the carbamate kinase family
H9X60_RS00850	COG1304	FMN binding
H9X60_RS00855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9X60_RS00865	COG0666	response to abiotic stimulus
H9X60_RS00870	COG0583	DNA-binding transcription factor activity
H9X60_RS00875	COG2819	hydrolase of the alpha beta superfamily
H9X60_RS00880	COG4771	TonB-dependent receptor
H9X60_RS00885	COG1566	PFAM secretion protein HlyD family protein
H9X60_RS00890	COG2814	Major facilitator Superfamily
H9X60_RS00895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9X60_RS00900	COG3327	negative regulation of DNA-templated transcription, initiation
H9X60_RS00905	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H9X60_RS00910	COG0183	Belongs to the thiolase family
H9X60_RS00915	COG2050	protein possibly involved in aromatic compounds catabolism
H9X60_RS00920	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9X60_RS00925	COG1024	Enoyl-CoA hydratase
H9X60_RS00930	COG1024	Enoyl-CoA hydratase
H9X60_RS00935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9X60_RS00940	COG2151	metal-sulfur cluster biosynthetic enzyme
H9X60_RS00945	COG3396	Phenylacetate-CoA oxygenase
H9X60_RS00950	COG3460	Phenylacetate-CoA oxygenase
H9X60_RS00955	COG3396	Phenylacetate-CoA oxygenase
H9X60_RS00960	COG2030	dehydratase
H9X60_RS00960	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS00965	COG2226	methyltransferase
H9X60_RS00980	COG0477	Major facilitator Superfamily
H9X60_RS00985	COG0028	Belongs to the TPP enzyme family
H9X60_RS00990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H9X60_RS01000	COG3189	MarR family transcriptional regulator
H9X60_RS01010	COG0488	(ABC) transporter
H9X60_RS01015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9X60_RS01020	COG1349	DNA-binding transcription factor activity
H9X60_RS01025	COG0705	Rhomboid family
H9X60_RS01030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9X60_RS01035	COG0316	Belongs to the HesB IscA family
H9X60_RS01035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9X60_RS01045	COG2267	carboxylic ester hydrolase activity
H9X60_RS01060	COG1918	ferrous iron import across plasma membrane
H9X60_RS01065	COG2183	response to ionizing radiation
H9X60_RS01070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9X60_RS01085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9X60_RS01090	COG0573	inorganic phosphate transmembrane transporter activity
H9X60_RS01095	COG0581	inorganic phosphate transmembrane transporter activity
H9X60_RS01105	COG0704	Plays a role in the regulation of phosphate uptake
H9X60_RS01110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9X60_RS01115	COG0765	amino acid transport
H9X60_RS01120	COG0765	amino acid transport
H9X60_RS01125	COG2252	PERMEase
H9X60_RS01130	COG3078	GTPase activator activity
H9X60_RS01135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9X60_RS01175	COG3539	Fimbrial protein
H9X60_RS01265	COG1695	Transcriptional regulator
H9X60_RS01280	COG1011	Hydrolase
H9X60_RS01290	COG0456	acetyltransferase
H9X60_RS01295	COG2982	Protein involved in outer membrane biogenesis
H9X60_RS01300	COG2233	PERMEase
H9X60_RS01305	COG0786	glutamate:sodium symporter activity
H9X60_RS01310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9X60_RS01315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9X60_RS01320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9X60_RS01325	COG1758	RNA polymerase activity
H9X60_RS01335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9X60_RS01340	COG2860	membrane
H9X60_RS01345	COG0823	Involved in the tonB-independent uptake of proteins
H9X60_RS01350	COG5645	(Lipo)protein
H9X60_RS01360	COG3977	Valine--pyruvate aminotransferase
H9X60_RS01365	COG2818	Glycosylase
H9X60_RS01375	COG0751	glycine-tRNA ligase activity
H9X60_RS01385	COG2831	hemolysin activation secretion protein
H9X60_RS01390	COG0747	negative chemotaxis
H9X60_RS01395	COG0601	transmembrane transport
H9X60_RS01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9X60_RS01405	COG0444	Belongs to the ABC transporter superfamily
H9X60_RS01410	COG4608	Belongs to the ABC transporter superfamily
H9X60_RS01420	COG0612	Peptidase, M16
H9X60_RS01425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9X60_RS01435	COG1295	ribonuclease BN
H9X60_RS01445	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9X60_RS01450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9X60_RS01460	COG2378	regulation of single-species biofilm formation
H9X60_RS01465	COG1763	Mo-molybdopterin cofactor biosynthetic process
H9X60_RS01470	COG0746	molybdenum cofactor guanylyltransferase activity
H9X60_RS01475	COG3084	Protein conserved in bacteria
H9X60_RS01480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H9X60_RS01485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9X60_RS01490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9X60_RS01490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9X60_RS01495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9X60_RS01520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9X60_RS01525	COG1765	OsmC-like protein
H9X60_RS01530	COG3954	Phosphoribulokinase
H9X60_RS01535	COG3089	Belongs to the UPF0270 family
H9X60_RS01540	COG0429	hydrolase of the alpha beta-hydrolase fold
H9X60_RS01550	COG1263	PTS System
H9X60_RS01550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS01555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9X60_RS01565	COG1982	Orn Lys Arg decarboxylase major
H9X60_RS01570	COG0488	(ABC) transporter
H9X60_RS01575	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9X60_RS01585	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H9X60_RS01590	COG1047	Peptidyl-prolyl cis-trans
H9X60_RS01595	COG2900	Belongs to the SlyX family
H9X60_RS01600	COG0545	Peptidyl-prolyl cis-trans isomerase
H9X60_RS01605	COG2964	Protein conserved in bacteria
H9X60_RS01610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H9X60_RS01620	COG2168	tRNA wobble position uridine thiolation
H9X60_RS01625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9X60_RS01630	COG0049	tRNA binding
H9X60_RS01635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9X60_RS01650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9X60_RS01655	COG0250	Participates in transcription elongation, termination and antitermination
H9X60_RS01660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9X60_RS01670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9X60_RS01675	COG0222	ribosome binding
H9X60_RS01680	COG0085	RNA polymerase activity
H9X60_RS01685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9X60_RS01695	COG3069	C4-dicarboxylate transmembrane transporter activity
H9X60_RS01700	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9X60_RS01705	COG3119	arylsulfatase activity
H9X60_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS01730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9X60_RS01735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS01735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS01740	COG3716	PTS system mannose fructose sorbose family IID component
H9X60_RS01745	COG3715	PTS system
H9X60_RS01750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS01755	COG2222	sugar isomerase
H9X60_RS01765	COG1349	DNA-binding transcription factor activity
H9X60_RS01770	COG0641	radical SAM
H9X60_RS01775	COG3119	arylsulfatase activity
H9X60_RS01795	COG2233	PERMEase
H9X60_RS01810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9X60_RS01825	COG2022	thiamine diphosphate biosynthetic process
H9X60_RS01830	COG2104	thiamine diphosphate biosynthetic process
H9X60_RS01835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9X60_RS01845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9X60_RS01855	COG3842	ATPase activity
H9X60_RS01860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H9X60_RS01880	COG2816	NAD+ diphosphatase activity
H9X60_RS01885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9X60_RS01890	COG1515	deoxyribonuclease V activity
H9X60_RS01895	COG3068	Protein conserved in bacteria
H9X60_RS01910	COG0151	Belongs to the GarS family
H9X60_RS01915	COG0138	bifunctional purine biosynthesis protein purh
H9X60_RS01945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H9X60_RS01950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9X60_RS01960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H9X60_RS01965	COG0800	Aldolase
H9X60_RS01970	COG0129	dihydroxy-acid dehydratase activity
H9X60_RS01985	COG3023	N-Acetylmuramoyl-L-alanine amidase
H9X60_RS01990	COG1414	Transcriptional regulator
H9X60_RS01995	COG1410	methionine synthase
H9X60_RS01995	COG0646	methionine synthase
H9X60_RS02010	COG0527	aspartate kinase activity
H9X60_RS02015	COG0166	Belongs to the GPI family
H9X60_RS02020	COG3161	chorismate lyase activity
H9X60_RS02030	COG2937	Belongs to the GPAT DAPAT family
H9X60_RS02035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9X60_RS02045	COG0735	belongs to the Fur family
H9X60_RS02075	COG3188	usher protein
H9X60_RS02085	COG3121	Chaperone
H9X60_RS02090	COG1446	asparaginase
H9X60_RS02110	COG0157	Belongs to the NadC ModD family
H9X60_RS02115	COG0500	methyltransferase
H9X60_RS02120	COG1120	ATPase activity
H9X60_RS02125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9X60_RS02135	COG1609	Transcriptional regulator
H9X60_RS02140	COG3265	gluconokinase activity
H9X60_RS02145	COG2610	gluconate transmembrane transporter activity
H9X60_RS02205	COG2992	FlgJ-related protein
H9X60_RS02235	COG2137	regulation of response to DNA damage stimulus
H9X60_RS02245	COG3069	C4-dicarboxylate transmembrane transporter activity
H9X60_RS02250	COG0814	amino acid
H9X60_RS02255	COG3119	arylsulfatase activity
H9X60_RS02265	COG0737	Belongs to the 5'-nucleotidase family
H9X60_RS02270	COG0738	Major facilitator superfamily
H9X60_RS02280	COG0641	radical SAM
H9X60_RS02290	COG2873	o-acetylhomoserine
H9X60_RS02295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9X60_RS02305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9X60_RS02310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9X60_RS02320	COG0789	Transcriptional regulator
H9X60_RS02335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9X60_RS02340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H9X60_RS02385	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9X60_RS02405	COG0025	NhaP-type Na H and K H
H9X60_RS02470	COG0243	molybdopterin cofactor binding
H9X60_RS02475	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS02485	COG3381	protein complex oligomerization
H9X60_RS02495	COG3541	Predicted nucleotidyltransferase
H9X60_RS02500	COG1690	Belongs to the RtcB family
H9X60_RS02510	COG4650	regulator
H9X60_RS02515	COG1470	cell adhesion involved in biofilm formation
H9X60_RS02515	COG1388	LysM domain
H9X60_RS02525	COG1349	DNA-binding transcription factor activity
H9X60_RS02530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9X60_RS02540	COG0738	Major facilitator superfamily
H9X60_RS02555	COG0668	transmembrane transport
H9X60_RS02560	COG1982	Orn Lys Arg decarboxylase major
H9X60_RS02565	COG1957	nucleoside hydrolase
H9X60_RS02575	COG0483	inositol monophosphate 1-phosphatase activity
H9X60_RS02580	COG3196	Protein conserved in bacteria
H9X60_RS02590	COG1335	isochorismatase
H9X60_RS02595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9X60_RS02625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9X60_RS02635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9X60_RS02650	COG2814	Major facilitator Superfamily
H9X60_RS02660	COG0028	Belongs to the TPP enzyme family
H9X60_RS02665	COG0440	acetolactate synthase activity
H9X60_RS02670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9X60_RS02695	COG2252	PERMEase
H9X60_RS02700	COG0025	NhaP-type Na H and K H
H9X60_RS02710	COG0583	DNA-binding transcription factor activity
H9X60_RS02715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9X60_RS02720	COG3753	Protein conserved in bacteria
H9X60_RS02725	COG2084	Dehydrogenase
H9X60_RS02730	COG3395	kinase activity
H9X60_RS02735	COG0235	Class ii aldolase
H9X60_RS02740	COG3622	Belongs to the hyi family
H9X60_RS02745	COG1349	DNA-binding transcription factor activity
H9X60_RS02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9X60_RS02755	COG2610	gluconate transmembrane transporter activity
H9X60_RS02760	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9X60_RS02770	COG0586	Pfam SNARE associated Golgi protein
H9X60_RS02780	COG2226	methyltransferase
H9X60_RS02785	COG3165	ubiquinone biosynthetic process from chorismate
H9X60_RS02795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9X60_RS02800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9X60_RS02805	COG0805	protein transport
H9X60_RS02820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H9X60_RS02830	COG0183	Belongs to the thiolase family
H9X60_RS02835	COG1024	Enoyl-CoA hydratase
H9X60_RS02835	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9X60_RS02845	COG0006	proline dipeptidase activity
H9X60_RS02850	COG1739	Uncharacterized protein family UPF0029
H9X60_RS02855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9X60_RS02885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9X60_RS02890	COG2197	response regulator
H9X60_RS02895	COG3850	Histidine kinase
H9X60_RS02900	COG2354	Protein conserved in bacteria
H9X60_RS02905	COG1216	Glycosyl transferase, family 2
H9X60_RS02920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9X60_RS02930	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS02940	COG0531	amino acid
H9X60_RS02955	COG1785	Belongs to the alkaline phosphatase family
H9X60_RS02980	COG2813	Specifically methylates the guanine in position
H9X60_RS02995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9X60_RS03005	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS03020	COG0583	DNA-binding transcription factor activity
H9X60_RS03025	COG0473	3-isopropylmalate dehydrogenase activity
H9X60_RS03030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9X60_RS03040	COG4667	esterase of the alpha-beta hydrolase superfamily
H9X60_RS03045	COG0084	hydrolase, TatD family'
H9X60_RS03050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9X60_RS03060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H9X60_RS03065	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9X60_RS03070	COG0813	purine-nucleoside phosphorylase activity
H9X60_RS03085	COG1247	-acetyltransferase
H9X60_RS03095	COG0612	Peptidase, M16
H9X60_RS03100	COG4178	(ABC) transporter
H9X60_RS03105	COG4771	TonB-dependent receptor
H9X60_RS03115	COG1595	DNA-templated transcription, initiation
H9X60_RS03125	COG3726	membrane protein affecting hemolysin expression
H9X60_RS03130	COG0560	Phosphoserine phosphatase
H9X60_RS03135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9X60_RS03145	COG0488	(ABC) transporter
H9X60_RS03160	COG0741	lytic transglycosylase activity
H9X60_RS03165	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H9X60_RS03170	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H9X60_RS03175	COG0406	alpha-ribazole phosphatase activity
H9X60_RS03180	COG3708	Transcriptional regulator
H9X60_RS03180	COG2207	Transcriptional regulator
H9X60_RS03185	COG3045	CreA protein
H9X60_RS03190	COG0745	RESPONSE REGULATOR receiver
H9X60_RS03205	COG0083	homoserine kinase activity
H9X60_RS03235	COG5002	protein histidine kinase activity
H9X60_RS03240	COG0745	RESPONSE REGULATOR receiver
H9X60_RS03270	COG0667	Aldo Keto reductase
H9X60_RS03275	COG3022	response to hydroperoxide
H9X60_RS03280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9X60_RS03285	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9X60_RS03290	COG1584	GPR1 FUN34 yaaH family protein
H9X60_RS03295	COG0443	Heat shock 70 kDa protein
H9X60_RS03300	COG0484	heat shock protein binding
H9X60_RS03305	COG0402	S-adenosylhomocysteine deaminase activity
H9X60_RS03315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9X60_RS03320	COG0583	DNA-binding transcription factor activity
H9X60_RS03325	COG0268	Binds directly to 16S ribosomal RNA
H9X60_RS03330	COG0196	riboflavin kinase activity
H9X60_RS03335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9X60_RS03340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9X60_RS03345	COG1047	Peptidyl-prolyl cis-trans
H9X60_RS03350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9X60_RS03355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9X60_RS03360	COG0505	Belongs to the CarA family
H9X60_RS03370	COG0789	Transcriptional regulator
H9X60_RS03380	COG0626	cystathionine gamma-synthase activity
H9X60_RS03390	COG0848	biopolymer transport protein
H9X60_RS03395	COG2391	methyltransferase activity
H9X60_RS03400	COG0425	Belongs to the sulfur carrier protein TusA family
H9X60_RS03410	COG2974	May be involved in recombination
H9X60_RS03415	COG1940	carbohydrate kinase activity
H9X60_RS03420	COG0737	Belongs to the 5'-nucleotidase family
H9X60_RS03450	COG0419	ATPase involved in DNA repair
H9X60_RS03455	COG0420	3'-5' exonuclease activity
H9X60_RS03460	COG0745	RESPONSE REGULATOR receiver
H9X60_RS03465	COG5002	protein histidine kinase activity
H9X60_RS03490	COG0450	alkyl hydroperoxide reductase
H9X60_RS03495	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H9X60_RS03500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9X60_RS03510	COG1862	Preprotein translocase
H9X60_RS03515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9X60_RS03520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9X60_RS03525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9X60_RS03530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9X60_RS03530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9X60_RS03535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9X60_RS03540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9X60_RS03545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9X60_RS03550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9X60_RS03555	COG2271	Major facilitator Superfamily
H9X60_RS03585	COG1960	acyl-CoA dehydrogenase activity
H9X60_RS03590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9X60_RS03595	COG0318	PFAM AMP-dependent synthetase and ligase
H9X60_RS03600	COG1024	Enoyl-CoA hydratase
H9X60_RS03615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9X60_RS03620	COG0142	geranyltranstransferase activity
H9X60_RS03630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9X60_RS03630	COG0301	tRNA thio-modification
H9X60_RS03645	COG0693	protein deglycase activity
H9X60_RS03650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9X60_RS03655	COG1666	GTP binding
H9X60_RS03660	COG2814	Major facilitator Superfamily
H9X60_RS03665	COG0109	protoheme IX farnesyltransferase activity
H9X60_RS03670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9X60_RS03675	COG1845	cytochrome c oxidase, subunit III
H9X60_RS03680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9X60_RS03685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9X60_RS03695	COG2223	nitrite transmembrane transporter activity
H9X60_RS03700	COG3056	Lipoprotein
H9X60_RS03705	COG0271	Belongs to the BolA IbaG family
H9X60_RS03710	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9X60_RS03715	COG0740	serine-type endopeptidase activity
H9X60_RS03720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9X60_RS03725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9X60_RS03730	COG0776	regulation of translation
H9X60_RS03735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9X60_RS03740	COG1555	photosystem II stabilization
H9X60_RS03745	COG0824	Thioesterase
H9X60_RS03755	COG1522	sequence-specific DNA binding
H9X60_RS03760	COG1132	(ABC) transporter
H9X60_RS03765	COG1132	(ABC) transporter
H9X60_RS03770	COG0347	Belongs to the P(II) protein family
H9X60_RS03775	COG0004	ammonium transporteR
H9X60_RS03780	COG1946	Acyl-CoA thioesterase
H9X60_RS03785	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H9X60_RS03805	COG1388	LysM domain
H9X60_RS03805	COG0741	lytic transglycosylase activity
H9X60_RS03810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9X60_RS03815	COG2226	methyltransferase
H9X60_RS03820	COG0328	RNA-DNA hybrid ribonuclease activity
H9X60_RS03835	COG1396	sequence-specific DNA binding
H9X60_RS03860	COG3188	usher protein
H9X60_RS03880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9X60_RS03885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9X60_RS03890	COG0126	phosphoglycerate kinase activity
H9X60_RS03905	COG0786	glutamate:sodium symporter activity
H9X60_RS03910	COG0010	Belongs to the arginase family
H9X60_RS03920	COG0583	DNA-binding transcription factor activity
H9X60_RS03930	COG0590	tRNA wobble adenosine to inosine editing
H9X60_RS03955	COG1704	LemA family
H9X60_RS04020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9X60_RS04025	COG2368	4-hydroxyphenylacetate
H9X60_RS04045	COG3971	2-oxopent-4-enoate hydratase activity
H9X60_RS04055	COG2814	Major facilitator Superfamily
H9X60_RS04065	COG3384	dioxygenase
H9X60_RS04070	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS04080	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9X60_RS04085	COG1846	Transcriptional regulator
H9X60_RS04090	COG2831	hemolysin activation secretion protein
H9X60_RS04095	COG2831	hemolysin activation secretion protein
H9X60_RS04100	COG3210	domain, Protein
H9X60_RS04150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9X60_RS04155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9X60_RS04175	COG2194	sulfuric ester hydrolase activity
H9X60_RS04180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9X60_RS04190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9X60_RS04200	COG3118	belongs to the thioredoxin family
H9X60_RS04210	COG1609	Transcriptional regulator
H9X60_RS04215	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9X60_RS04220	COG1129	ABC transporter
H9X60_RS04225	COG1879	ABC-type sugar transport system periplasmic component
H9X60_RS04230	COG1063	alcohol dehydrogenase
H9X60_RS04235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9X60_RS04245	COG0583	DNA-binding transcription factor activity
H9X60_RS04250	COG1285	pathogenesis
H9X60_RS04255	COG2211	Major facilitator Superfamily
H9X60_RS04275	COG0741	lytic transglycosylase activity
H9X60_RS04280	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9X60_RS04285	COG1194	a g-specific adenine glycosylase
H9X60_RS04295	COG3171	Protein conserved in bacteria
H9X60_RS04300	COG2066	Belongs to the glutaminase family
H9X60_RS04310	COG4607	ABC-type enterochelin transport system periplasmic component
H9X60_RS04315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9X60_RS04320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9X60_RS04325	COG0762	integral membrane protein
H9X60_RS04330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9X60_RS04335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9X60_RS04340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9X60_RS04345	COG1678	Uncharacterized ACR, COG1678
H9X60_RS04350	COG0189	ligase activity
H9X60_RS04355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9X60_RS04375	COG0583	DNA-binding transcription factor activity
H9X60_RS04380	COG0583	DNA-binding transcription factor activity
H9X60_RS04405	COG1960	acyl-CoA dehydrogenase activity
H9X60_RS04415	COG0121	glutamine amidotransferase
H9X60_RS04420	COG3034	peptidoglycan biosynthetic process
H9X60_RS04425	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9X60_RS04430	COG1805	sodium ion transport
H9X60_RS04435	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9X60_RS04440	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9X60_RS04445	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9X60_RS04450	COG2871	sodium ion transport
H9X60_RS04455	COG1477	protein flavinylation
H9X60_RS04460	COG2991	Protein conserved in bacteria
H9X60_RS04475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9X60_RS04480	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9X60_RS04485	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9X60_RS04490	COG1073	alpha beta
H9X60_RS04505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9X60_RS04510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9X60_RS04515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9X60_RS04520	COG0204	Acyl-transferase
H9X60_RS04520	COG0318	PFAM AMP-dependent synthetase and ligase
H9X60_RS04525	COG2814	Major facilitator Superfamily
H9X60_RS04530	COG1546	Belongs to the CinA family
H9X60_RS04535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9X60_RS04540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9X60_RS04545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H9X60_RS04570	COG2918	glutathione biosynthetic process
H9X60_RS04575	COG1854	S-ribosylhomocysteine lyase activity
H9X60_RS04580	COG4536	flavin adenine dinucleotide binding
H9X60_RS04585	COG4137	Cytochrome C assembly protein
H9X60_RS04590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9X60_RS04595	COG0228	four-way junction DNA binding
H9X60_RS04605	COG0336	Belongs to the RNA methyltransferase TrmD family
H9X60_RS04610	COG0335	large ribosomal subunit rRNA binding
H9X60_RS04615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9X60_RS04620	COG0287	Prephenate dehydrogenase
H9X60_RS04620	COG1605	Chorismate mutase
H9X60_RS04625	COG0840	transmembrane signaling receptor activity
H9X60_RS04630	COG1605	Chorismate mutase
H9X60_RS04630	COG0077	Prephenate dehydratase
H9X60_RS04635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9X60_RS04640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9X60_RS04645	COG0564	pseudouridine synthase activity
H9X60_RS04650	COG1496	oxidoreductase activity
H9X60_RS04655	COG0542	response to heat
H9X60_RS04685	COG3021	interspecies interaction between organisms
H9X60_RS04690	COG3738	Protein conserved in bacteria
H9X60_RS04715	COG0602	queuosine metabolic process
H9X60_RS04720	COG3477	response to acidic pH
H9X60_RS04725	COG0720	synthase
H9X60_RS04730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9X60_RS04735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9X60_RS04745	COG1648	precorrin-2 dehydrogenase activity
H9X60_RS04745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9X60_RS04750	COG0175	sulfate reduction
H9X60_RS04755	COG2895	sulfate adenylyltransferase (ATP) activity
H9X60_RS04760	COG0529	Catalyzes the synthesis of activated sulfate
H9X60_RS04765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9X60_RS04770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9X60_RS04775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9X60_RS04780	COG0585	pseudouridine synthase activity
H9X60_RS04785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9X60_RS04790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9X60_RS04795	COG4942	peptidase
H9X60_RS04795	COG1388	LysM domain
H9X60_RS04810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9X60_RS04835	COG2010	Cytochrome c
H9X60_RS04835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9X60_RS04850	COG2010	Cytochrome c
H9X60_RS04850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9X60_RS04875	COG3961	Belongs to the TPP enzyme family
H9X60_RS04880	COG0251	oxidation-reduction process
H9X60_RS04890	COG0583	DNA-binding transcription factor activity
H9X60_RS04895	COG0786	glutamate:sodium symporter activity
H9X60_RS04910	COG2252	PERMEase
H9X60_RS04920	COG0583	DNA-binding transcription factor activity
H9X60_RS04940	COG2822	iron ion transport
H9X60_RS04950	COG4633	Protein conserved in bacteria
H9X60_RS04965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9X60_RS04975	COG4566	intracellular signal transduction
H9X60_RS04995	COG2962	Rard protein
H9X60_RS05010	COG1966	Carbon starvation protein
H9X60_RS05015	COG2879	small protein
H9X60_RS05020	COG0523	cobalamin synthesis protein
H9X60_RS05030	COG0534	Mate efflux family protein
H9X60_RS05035	COG0673	inositol 2-dehydrogenase activity
H9X60_RS05045	COG5564	TIM-barrel signal transduction protein
H9X60_RS05050	COG5441	Belongs to the UPF0261 family
H9X60_RS05070	COG2132	Multicopper oxidase
H9X60_RS05100	COG3121	Chaperone
H9X60_RS05110	COG0842	Transport permease protein
H9X60_RS05115	COG1131	(ABC) transporter
H9X60_RS05120	COG0288	reversible hydration of carbon dioxide
H9X60_RS05125	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9X60_RS05130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9X60_RS05135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9X60_RS05140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9X60_RS05155	COG1489	DNA binding
H9X60_RS05160	COG1643	Atp-dependent helicase
H9X60_RS05165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9X60_RS05170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9X60_RS05185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9X60_RS05195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9X60_RS05200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9X60_RS05205	COG3956	TIGRFAM MazG family protein
H9X60_RS05210	COG0504	CTP synthase activity
H9X60_RS05215	COG0148	phosphopyruvate hydratase activity
H9X60_RS05225	COG0471	metal ion transport
H9X60_RS05230	COG3210	domain, Protein
H9X60_RS05230	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
H9X60_RS05230	COG3064	Membrane
H9X60_RS05250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9X60_RS05255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9X60_RS05260	COG1309	transcriptional regulator
H9X60_RS05265	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H9X60_RS05270	COG3264	Mechanosensitive ion channel
H9X60_RS05270	COG1196	nuclear chromosome segregation
H9X60_RS05285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9X60_RS05290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9X60_RS05295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9X60_RS05300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9X60_RS05305	COG0326	Molecular chaperone. Has ATPase activity
H9X60_RS05310	COG0563	adenylate kinase activity
H9X60_RS05320	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H9X60_RS05325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS05335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9X60_RS05350	COG1349	DNA-binding transcription factor activity
H9X60_RS05365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9X60_RS05365	COG4651	solute:proton antiporter activity
H9X60_RS05370	COG2223	nitrite transmembrane transporter activity
H9X60_RS05375	COG0737	Belongs to the 5'-nucleotidase family
H9X60_RS05385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9X60_RS05390	COG3735	TraB family
H9X60_RS05395	COG3247	response to pH
H9X60_RS05400	COG2217	Heavy metal translocating P-type atpase
H9X60_RS05410	COG1585	Membrane protein implicated in regulation of membrane protease activity
H9X60_RS05415	COG0330	HflC and HflK could
H9X60_RS05420	COG3118	belongs to the thioredoxin family
H9X60_RS05425	COG0300	oxidoreductase activity
H9X60_RS05430	COG2755	lipolytic protein G-D-S-L family
H9X60_RS05435	COG4181	ATPase activity
H9X60_RS05440	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H9X60_RS05455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9X60_RS05460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9X60_RS05465	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9X60_RS05470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9X60_RS05475	COG0215	cysteine-tRNA ligase activity
H9X60_RS05485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9X60_RS05485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9X60_RS05485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9X60_RS05490	COG1105	Belongs to the carbohydrate kinase PfkB family
H9X60_RS05495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS05495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS05500	COG2501	S4 domain
H9X60_RS05505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9X60_RS05515	COG0582	viral genome integration into host DNA
H9X60_RS05530	COG0515	serine threonine protein kinase
H9X60_RS05530	COG2815	serine threonine protein kinase
H9X60_RS05555	COG3596	GTP binding
H9X60_RS05570	COG2378	regulation of single-species biofilm formation
H9X60_RS05620	COG0640	Transcriptional regulator
H9X60_RS05625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H9X60_RS05635	COG0784	Response regulator, receiver
H9X60_RS05635	COG2205	protein histidine kinase activity
H9X60_RS05635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9X60_RS05635	COG2198	Histidine kinase
H9X60_RS05645	COG2197	response regulator
H9X60_RS05665	COG3539	Fimbrial protein
H9X60_RS05700	COG1473	amidohydrolase
H9X60_RS05760	COG3005	denitrification pathway
H9X60_RS05765	COG0745	RESPONSE REGULATOR receiver
H9X60_RS05770	COG1879	ABC-type sugar transport system periplasmic component
H9X60_RS05775	COG2198	Histidine kinase
H9X60_RS05775	COG0784	Response regulator, receiver
H9X60_RS05775	COG2205	protein histidine kinase activity
H9X60_RS05780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9X60_RS05785	COG0402	S-adenosylhomocysteine deaminase activity
H9X60_RS05790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H9X60_RS05795	COG0583	DNA-binding transcription factor activity
H9X60_RS05805	COG0513	Belongs to the DEAD box helicase family
H9X60_RS05815	COG1288	antiporter activity
H9X60_RS05825	COG0626	cystathionine gamma-synthase activity
H9X60_RS05835	COG0626	cystathionine gamma-synthase activity
H9X60_RS05840	COG3381	protein complex oligomerization
H9X60_RS05845	COG3302	dmso reductase anchor subunit
H9X60_RS05850	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS05855	COG0243	molybdopterin cofactor binding
H9X60_RS05860	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9X60_RS05870	COG0583	DNA-binding transcription factor activity
H9X60_RS05880	COG0443	Heat shock 70 kDa protein
H9X60_RS05890	COG4235	cytochrome complex assembly
H9X60_RS05895	COG1138	Cytochrome C-type biogenesis protein
H9X60_RS05900	COG3301	Polysulphide reductase, NrfD
H9X60_RS05905	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS05910	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H9X60_RS05920	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9X60_RS05920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9X60_RS05925	COG3062	negative regulation of establishment of protein localization
H9X60_RS05935	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS05940	COG0348	domain, Protein
H9X60_RS05945	COG3043	anaerobic respiration
H9X60_RS05950	COG3005	denitrification pathway
H9X60_RS05955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9X60_RS05960	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9X60_RS05970	COG1138	Cytochrome C-type biogenesis protein
H9X60_RS05975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9X60_RS05980	COG3088	subunit of a heme lyase
H9X60_RS05980	COG4235	cytochrome complex assembly
H9X60_RS05985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS06000	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H9X60_RS06015	COG3708	Transcriptional regulator
H9X60_RS06015	COG2207	Transcriptional regulator
H9X60_RS06040	COG3962	Belongs to the TPP enzyme family
H9X60_RS06045	COG0673	inositol 2-dehydrogenase activity
H9X60_RS06050	COG2814	Major facilitator Superfamily
H9X60_RS06065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS06075	COG3718	enzyme involved in inositol metabolism
H9X60_RS06100	COG3038	cytochrome b561
H9X60_RS06105	COG2353	YceI-like domain
H9X60_RS06130	COG1151	hydroxylamine reductase activity
H9X60_RS06135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9X60_RS06145	COG2239	Acts as a magnesium transporter
H9X60_RS06150	COG3091	SprT-like family
H9X60_RS06155	COG0640	Transcriptional regulator
H9X60_RS06170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9X60_RS06180	COG1166	arginine decarboxylase activity
H9X60_RS06185	COG0010	Belongs to the arginase family
H9X60_RS06205	COG0861	Integral membrane protein TerC family
H9X60_RS06210	COG3066	DNA modification
H9X60_RS06215	COG4533	DNA binding
H9X60_RS06225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9X60_RS06235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9X60_RS06250	COG1022	Amp-dependent synthetase and ligase
H9X60_RS06255	COG0028	Belongs to the TPP enzyme family
H9X60_RS06270	COG2001	Belongs to the MraZ family
H9X60_RS06275	COG0275	rRNA processing
H9X60_RS06280	COG3116	cell division
H9X60_RS06285	COG0768	penicillin binding
H9X60_RS06290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9X60_RS06295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9X60_RS06300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9X60_RS06305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9X60_RS06310	COG0772	Belongs to the SEDS family
H9X60_RS06315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9X60_RS06320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9X60_RS06325	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9X60_RS06330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9X60_RS06335	COG0849	cell division
H9X60_RS06340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9X60_RS06345	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9X60_RS06360	COG0653	protein targeting
H9X60_RS06365	COG0494	nUDIX hydrolase
H9X60_RS06375	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H9X60_RS06380	COG0237	dephospho-CoA kinase activity
H9X60_RS06390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9X60_RS06395	COG4969	Belongs to the N-Me-Phe pilin family
H9X60_RS06400	COG3023	N-Acetylmuramoyl-L-alanine amidase
H9X60_RS06410	COG2186	Transcriptional regulator
H9X60_RS06415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9X60_RS06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9X60_RS06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9X60_RS06490	COG3112	Uncharacterised protein family (UPF0231)
H9X60_RS06495	COG0668	transmembrane transport
H9X60_RS06500	COG1279	arginine transmembrane transporter activity
H9X60_RS06510	COG0583	DNA-binding transcription factor activity
H9X60_RS06515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9X60_RS06520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9X60_RS06525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9X60_RS06535	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H9X60_RS06540	COG3079	Belongs to the UPF0149 family
H9X60_RS06545	COG0006	proline dipeptidase activity
H9X60_RS06550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9X60_RS06555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9X60_RS06560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9X60_RS06565	COG0509	glycine decarboxylation via glycine cleavage system
H9X60_RS06570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9X60_RS06570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9X60_RS06585	COG0354	folic acid binding
H9X60_RS06590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9X60_RS06600	COG0716	FMN binding
H9X60_RS06610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9X60_RS06615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9X60_RS06625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9X60_RS06660	COG0589	response to stress
H9X60_RS06670	COG2017	converts alpha-aldose to the beta-anomer
H9X60_RS06675	COG2079	MmgE PrpD family protein
H9X60_RS06680	COG0372	Belongs to the citrate synthase family
H9X60_RS06685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H9X60_RS06690	COG3829	transcription factor binding
H9X60_RS06695	COG0477	Major facilitator Superfamily
H9X60_RS06715	COG3781	membrane
H9X60_RS06745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9X60_RS06750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9X60_RS06755	COG4558	Periplasmic binding protein
H9X60_RS06760	COG3720	iron ion transport
H9X60_RS06775	COG4256	Hemin uptake protein
H9X60_RS06780	COG0702	epimerase
H9X60_RS06795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9X60_RS06805	COG1414	Transcriptional regulator
H9X60_RS06820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9X60_RS06825	COG2017	converts alpha-aldose to the beta-anomer
H9X60_RS06830	COG1609	Transcriptional regulator
H9X60_RS06840	COG4774	siderophore transport
H9X60_RS06845	COG1120	ATPase activity
H9X60_RS06870	COG2211	Major facilitator Superfamily
H9X60_RS06875	COG0673	inositol 2-dehydrogenase activity
H9X60_RS06885	COG0673	inositol 2-dehydrogenase activity
H9X60_RS06900	COG2246	polysaccharide biosynthetic process
H9X60_RS06925	COG1442	glycosyl transferase family 8
H9X60_RS06930	COG3306	glycosyltransferase involved in LPS biosynthesis
H9X60_RS06940	COG2963	transposase activity
H9X60_RS07005	COG3257	ureidoglycine aminohydrolase activity
H9X60_RS07010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9X60_RS07015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H9X60_RS07020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9X60_RS07025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9X60_RS07035	COG0549	Belongs to the carbamate kinase family
H9X60_RS07040	COG0656	L-ascorbic acid biosynthetic process
H9X60_RS07045	COG0583	DNA-binding transcription factor activity
H9X60_RS07060	COG3960	tartronate-semialdehyde synthase activity
H9X60_RS07065	COG3622	Belongs to the hyi family
H9X60_RS07070	COG2084	Dehydrogenase
H9X60_RS07075	COG2233	PERMEase
H9X60_RS07085	COG1953	Uracil, thiamine, allantoin
H9X60_RS07090	COG1929	Belongs to the glycerate kinase type-1 family
H9X60_RS07120	COG3477	response to acidic pH
H9X60_RS07125	COG3111	PFAM Bacterial OB fold (BOF) protein
H9X60_RS07145	COG0754	glutathionylspermidine amidase activity
H9X60_RS07150	COG5510	response to toxic substance
H9X60_RS07155	COG3040	lipid binding
H9X60_RS07195	COG2003	Belongs to the UPF0758 family
H9X60_RS07250	COG2378	regulation of single-species biofilm formation
H9X60_RS07255	COG4735	regulation of single-species biofilm formation
H9X60_RS07260	COG4983	Phage plasmid primase, P4 family domain protein
H9X60_RS07270	COG3676	manually curated
H9X60_RS07290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9X60_RS07315	COG0582	viral genome integration into host DNA
H9X60_RS07330	COG2867	negative regulation of translational initiation
H9X60_RS07335	COG2914	Belongs to the UPF0125 (RnfH) family
H9X60_RS07340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9X60_RS07345	COG0497	DNA recombination
H9X60_RS07350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9X60_RS07355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9X60_RS07360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9X60_RS07375	COG0513	Belongs to the DEAD box helicase family
H9X60_RS07380	COG0786	glutamate:sodium symporter activity
H9X60_RS07395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9X60_RS07400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9X60_RS07420	COG3086	response to oxidative stress
H9X60_RS07440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9X60_RS07445	COG1381	Involved in DNA repair and RecF pathway recombination
H9X60_RS07450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9X60_RS07455	COG0736	holo-[acyl-carrier-protein] synthase activity
H9X60_RS07460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9X60_RS07480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H9X60_RS07485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9X60_RS07485	COG0047	phosphoribosylformylglycinamidine synthase activity
H9X60_RS07490	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H9X60_RS07495	COG0561	phosphatase activity
H9X60_RS07525	COG3842	ATPase activity
H9X60_RS07535	COG1840	ABC-type Fe3 transport system, periplasmic component
H9X60_RS07540	COG2271	Major facilitator Superfamily
H9X60_RS07560	COG2205	protein histidine kinase activity
H9X60_RS07565	COG3170	Tfp pilus assembly protein FimV
H9X60_RS07570	COG2204	response regulator
H9X60_RS07575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9X60_RS07575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9X60_RS07580	COG0347	Belongs to the P(II) protein family
H9X60_RS07585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9X60_RS07585	COG1017	nitric oxide dioxygenase activity
H9X60_RS07590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9X60_RS07595	COG2814	Major facilitator Superfamily
H9X60_RS07600	COG3121	Chaperone
H9X60_RS07615	COG3121	Chaperone
H9X60_RS07625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9X60_RS07635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9X60_RS07645	COG1802	Transcriptional regulator
H9X60_RS07650	COG1063	alcohol dehydrogenase
H9X60_RS07655	COG0483	inositol monophosphate 1-phosphatase activity
H9X60_RS07660	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H9X60_RS07665	COG1959	2 iron, 2 sulfur cluster binding
H9X60_RS07670	COG1104	cysteine desulfurase activity
H9X60_RS07675	COG0822	iron-sulfur transferase activity
H9X60_RS07680	COG0316	Belongs to the HesB IscA family
H9X60_RS07690	COG0443	Heat shock 70 kDa protein
H9X60_RS07695	COG0633	Ferredoxin
H9X60_RS07710	COG2975	iron-sulfur cluster assembly
H9X60_RS07715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9X60_RS07725	COG2373	Large extracellular alpha-helical protein
H9X60_RS07730	COG4953	penicillin-binding protein 1C
H9X60_RS07735	COG0105	UTP biosynthetic process
H9X60_RS07740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9X60_RS07755	COG0124	histidyl-tRNA synthetase
H9X60_RS07760	COG2976	Protein conserved in bacteria
H9X60_RS07765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9X60_RS07775	COG1187	pseudouridine synthase activity
H9X60_RS07785	COG0408	coproporphyrinogen oxidase activity
H9X60_RS07790	COG0456	acetyltransferase
H9X60_RS07800	COG2837	iron assimilation
H9X60_RS07815	COG4150	thiosulfate binding
H9X60_RS07825	COG4208	sulfate ABC transporter
H9X60_RS07830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H9X60_RS07835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9X60_RS07840	COG2190	(PTS) system
H9X60_RS07845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9X60_RS07850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS07865	COG3115	cell septum assembly
H9X60_RS07870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9X60_RS07875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9X60_RS07880	COG3530	Putative quorum-sensing-regulated virulence factor
H9X60_RS07905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9X60_RS07935	COG1396	sequence-specific DNA binding
H9X60_RS07945	COG2011	ABC-type metal ion transport system permease component
H9X60_RS07950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9X60_RS07955	COG2072	flavoprotein involved in K transport
H9X60_RS07980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS07980	COG2213	PTS system mannitol-specific
H9X60_RS07990	COG3722	fumarate hydratase activity
H9X60_RS08020	COG2067	long-chain fatty acid transport protein
H9X60_RS08025	COG3691	Protein conserved in bacteria
H9X60_RS08030	COG0183	Belongs to the thiolase family
H9X60_RS08035	COG1024	Enoyl-CoA hydratase
H9X60_RS08035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9X60_RS08040	COG2062	phosphohistidine phosphatase, SixA
H9X60_RS08045	COG2840	Smr protein MutS2
H9X60_RS08050	COG1228	amidohydrolase
H9X60_RS08060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9X60_RS08065	COG2986	histidine ammonia-lyase
H9X60_RS08080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9X60_RS08085	COG0730	response to heat
H9X60_RS08090	COG3101	peptidyl-lysine hydroxylation
H9X60_RS08105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9X60_RS08105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9X60_RS08110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9X60_RS08140	COG0642	Histidine kinase
H9X60_RS08160	COG0697	spore germination
H9X60_RS08165	COG2207	Transcriptional regulator
H9X60_RS08170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9X60_RS08175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9X60_RS08180	COG0101	tRNA pseudouridine synthase activity
H9X60_RS08185	COG0586	Pfam SNARE associated Golgi protein
H9X60_RS08190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9X60_RS08195	COG0285	dihydrofolate synthase activity
H9X60_RS08200	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H9X60_RS08205	COG1286	toxin biosynthetic process
H9X60_RS08210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9X60_RS08215	COG3878	Protein conserved in bacteria
H9X60_RS08225	COG1090	epimerase
H9X60_RS08230	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9X60_RS08245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9X60_RS08250	COG0857	belongs to the CobB CobQ family
H9X60_RS08250	COG0280	phosphate acetyltransferase
H9X60_RS08255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9X60_RS08260	COG3092	negative regulation of chromosome organization
H9X60_RS08265	COG3013	Belongs to the UPF0304 family
H9X60_RS08330	COG3501	Rhs element vgr protein
H9X60_RS08340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9X60_RS08345	COG0490	domain, Protein
H9X60_RS08345	COG0471	metal ion transport
H9X60_RS08360	COG0436	Aminotransferase
H9X60_RS08365	COG0583	DNA-binding transcription factor activity
H9X60_RS08370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9X60_RS08380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9X60_RS08380	COG0649	NAD binding
H9X60_RS08390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H9X60_RS08400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9X60_RS08405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9X60_RS08410	COG0839	Belongs to the complex I subunit 6 family
H9X60_RS08415	COG0713	ATP synthesis coupled electron transport
H9X60_RS08420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9X60_RS08425	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9X60_RS08430	COG1007	ATP synthesis coupled electron transport
H9X60_RS08445	COG1169	isochorismate synthase
H9X60_RS08450	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9X60_RS08460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9X60_RS08465	COG1441	menaquinone biosynthetic process
H9X60_RS08485	COG5464	transposase or invertase
H9X60_RS08490	COG0814	amino acid
H9X60_RS08495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9X60_RS08500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9X60_RS08505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9X60_RS08510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9X60_RS08515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9X60_RS08525	COG2205	protein histidine kinase activity
H9X60_RS08525	COG0784	Response regulator, receiver
H9X60_RS08535	COG0642	Histidine kinase
H9X60_RS08535	COG2198	Histidine kinase
H9X60_RS08550	COG0582	viral genome integration into host DNA
H9X60_RS08795	COG5410	chromosome segregation
H9X60_RS08945	COG1560	Kdo2-lipid A biosynthetic process
H9X60_RS08950	COG1301	dicarboxylic acid transport
H9X60_RS08960	COG1914	H( )-stimulated, divalent metal cation uptake system
H9X60_RS08965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9X60_RS08970	COG4336	lyase activity
H9X60_RS08980	COG4770	biotin carboxylase activity
H9X60_RS08995	COG3381	protein complex oligomerization
H9X60_RS09000	COG3302	dmso reductase anchor subunit
H9X60_RS09005	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS09010	COG0243	molybdopterin cofactor binding
H9X60_RS09015	COG0668	transmembrane transport
H9X60_RS09030	COG1335	isochorismatase
H9X60_RS09060	COG2226	methyltransferase
H9X60_RS09075	COG3083	sulfuric ester hydrolase activity
H9X60_RS09080	COG3082	Protein of unknown function (DUF1414)
H9X60_RS09085	COG3081	Nucleoid-associated protein
H9X60_RS09090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9X60_RS09095	COG1061	Type III restriction enzyme res subunit
H9X60_RS09100	COG1187	pseudouridine synthase activity
H9X60_RS09105	COG2814	Major facilitator Superfamily
H9X60_RS09115	COG0791	NLP P60 protein
H9X60_RS09130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9X60_RS09135	COG0814	amino acid
H9X60_RS09145	COG1105	Belongs to the carbohydrate kinase PfkB family
H9X60_RS09150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9X60_RS09155	COG2855	membrane
H9X60_RS09160	COG0583	DNA-binding transcription factor activity
H9X60_RS09165	COG0833	amino acid
H9X60_RS09175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9X60_RS09180	COG1120	ATPase activity
H9X60_RS09185	COG4771	TonB-dependent receptor
H9X60_RS09195	COG0531	amino acid
H9X60_RS09200	COG0277	FAD linked oxidase domain protein
H9X60_RS09205	COG2925	Exonuclease
H9X60_RS09210	COG2211	Major facilitator Superfamily
H9X60_RS09215	COG2926	Belongs to the UPF0265 family
H9X60_RS09225	COG0243	molybdopterin cofactor binding
H9X60_RS09230	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS09245	COG1530	ribonuclease E activity
H9X60_RS09250	COG0564	pseudouridine synthase activity
H9X60_RS09255	COG0424	maF-like protein
H9X60_RS09260	COG1399	metal-binding, possibly nucleic acid-binding protein
H9X60_RS09265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9X60_RS09270	COG0416	fatty acid biosynthetic process
H9X60_RS09275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9X60_RS09280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9X60_RS09290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9X60_RS09295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9X60_RS09300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9X60_RS09305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9X60_RS09310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9X60_RS09315	COG0470	DNA polymerase III
H9X60_RS09320	COG0084	hydrolase, TatD family'
H9X60_RS09325	COG0537	adenosine 5'-monophosphoramidase activity
H9X60_RS09335	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H9X60_RS09340	COG0510	thiamine kinase activity
H9X60_RS09345	COG1472	Belongs to the glycosyl hydrolase 3 family
H9X60_RS09355	COG0737	Belongs to the 5'-nucleotidase family
H9X60_RS09360	COG1252	NADH dehydrogenase
H9X60_RS09370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9X60_RS09375	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9X60_RS09380	COG1136	(ABC) transporter
H9X60_RS09385	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9X60_RS09395	COG2862	Uncharacterized protein family, UPF0114
H9X60_RS09405	COG0300	oxidoreductase activity
H9X60_RS09415	COG1280	lysine exporter protein (LysE YggA)
H9X60_RS09420	COG2850	peptidyl-arginine hydroxylation
H9X60_RS09430	COG0745	RESPONSE REGULATOR receiver
H9X60_RS09440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9X60_RS09445	COG2915	High frequency lysogenization protein hflD homolog
H9X60_RS09450	COG0482	sulfurtransferase activity
H9X60_RS09460	COG1187	pseudouridine synthase activity
H9X60_RS09465	COG0538	isocitrate dehydrogenase activity
H9X60_RS09470	COG0582	viral genome integration into host DNA
H9X60_RS09480	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H9X60_RS09550	COG1403	HNH endonuclease
H9X60_RS09565	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H9X60_RS09585	COG3772	lysozyme
H9X60_RS09625	COG0740	serine-type endopeptidase activity
H9X60_RS09725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9X60_RS09730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9X60_RS09745	COG0538	isocitrate dehydrogenase activity
H9X60_RS09785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H9X60_RS09805	COG1396	sequence-specific DNA binding
H9X60_RS09810	COG2315	Protein conserved in bacteria
H9X60_RS09820	COG0384	phenazine biosynthesis protein PhzF
H9X60_RS09840	COG0840	transmembrane signaling receptor activity
H9X60_RS09855	COG2226	methyltransferase
H9X60_RS09870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9X60_RS09905	COG1115	amino acid carrier protein
H9X60_RS09915	COG0561	phosphatase activity
H9X60_RS09920	COG2207	Transcriptional regulator
H9X60_RS09930	COG1113	amino acid transport
H9X60_RS09940	COG1328	CTP reductase activity
H9X60_RS09945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9X60_RS09955	COG1597	lipid kinase activity
H9X60_RS09960	COG0826	peptidase U32
H9X60_RS09965	COG0745	RESPONSE REGULATOR receiver
H9X60_RS09970	COG2205	protein histidine kinase activity
H9X60_RS09975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9X60_RS09980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9X60_RS09985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9X60_RS09995	COG2239	Acts as a magnesium transporter
H9X60_RS10005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9X60_RS10010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9X60_RS10015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9X60_RS10020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9X60_RS10025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9X60_RS10030	COG2233	PERMEase
H9X60_RS10035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9X60_RS10040	COG1393	Belongs to the ArsC family
H9X60_RS10045	COG4783	chaperone-mediated protein folding
H9X60_RS10050	COG0628	permease
H9X60_RS10055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9X60_RS10060	COG2716	regulation of RNA biosynthetic process
H9X60_RS10070	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H9X60_RS10075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9X60_RS10080	COG1122	ATPase activity
H9X60_RS10085	COG1122	ATPase activity
H9X60_RS10105	COG2707	UPF0756 membrane protein
H9X60_RS10110	COG1444	tRNA N-acetyltransferase activity
H9X60_RS10120	COG2832	Protein of unknown function (DUF454)
H9X60_RS10125	COG1876	peptidase activity
H9X60_RS10130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9X60_RS10135	COG1393	Belongs to the ArsC family
H9X60_RS10140	COG2197	response regulator
H9X60_RS10145	COG0281	malic enzyme
H9X60_RS10145	COG0280	phosphate acetyltransferase
H9X60_RS10160	COG1770	oligopeptidase
H9X60_RS10165	COG1629	transport
H9X60_RS10165	COG4206	TonB-dependent receptor
H9X60_RS10170	COG1570	exodeoxyribonuclease VII activity
H9X60_RS10175	COG0516	GMP reductase activity
H9X60_RS10175	COG0517	IMP dehydrogenase activity
H9X60_RS10180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9X60_RS10180	COG0519	Catalyzes the synthesis of GMP from XMP
H9X60_RS10185	COG0582	viral genome integration into host DNA
H9X60_RS10430	COG0386	Belongs to the glutathione peroxidase family
H9X60_RS10440	COG0667	Aldo Keto reductase
H9X60_RS10445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9X60_RS10455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9X60_RS10465	COG2226	methyltransferase
H9X60_RS10470	COG1971	Probably functions as a manganese efflux pump
H9X60_RS10475	COG4811	Protein of unknown function (DUF986)
H9X60_RS10480	COG3716	PTS system mannose fructose sorbose family IID component
H9X60_RS10485	COG3715	PTS system
H9X60_RS10490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS10490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS10495	COG1760	l-serine dehydratase
H9X60_RS10500	COG0494	nUDIX hydrolase
H9X60_RS10505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9X60_RS10510	COG3140	Belongs to the UPF0181 family
H9X60_RS10525	COG1528	Iron-storage protein
H9X60_RS10530	COG2372	response to copper ion
H9X60_RS10535	COG1276	copper resistance
H9X60_RS10550	COG3008	intermembrane lipid transfer
H9X60_RS10555	COG2995	paraquat-inducible protein a
H9X60_RS10560	COG1956	GAF domain-containing protein
H9X60_RS10565	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H9X60_RS10580	COG0501	Belongs to the peptidase M48B family
H9X60_RS10585	COG1115	amino acid carrier protein
H9X60_RS10600	COG2814	Major facilitator Superfamily
H9X60_RS10620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H9X60_RS10625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9X60_RS10630	COG2186	Transcriptional regulator
H9X60_RS10635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9X60_RS10640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9X60_RS10645	COG3713	MltA-interacting MipA family protein
H9X60_RS10660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9X60_RS10665	COG3139	Protein of unknown function (DUF1315)
H9X60_RS10670	COG1335	isochorismatase
H9X60_RS10675	COG0252	asparaginase activity
H9X60_RS10680	COG0616	signal peptide processing
H9X60_RS10685	COG0778	Nitroreductase
H9X60_RS10690	COG0709	Synthesizes selenophosphate from selenide and ATP
H9X60_RS10695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9X60_RS10700	COG0708	Exodeoxyribonuclease III
H9X60_RS10715	COG0788	formyltetrahydrofolate deformylase activity
H9X60_RS10720	COG3012	SEC-C Motif Domain Protein
H9X60_RS10725	COG0745	RESPONSE REGULATOR receiver
H9X60_RS10730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9X60_RS10735	COG2916	Histone family protein nucleoid-structuring protein H-NS
H9X60_RS10740	COG1435	thymidine kinase activity
H9X60_RS10745	COG1454	alcohol dehydrogenase
H9X60_RS10745	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS10750	COG2095	MarC family integral membrane protein
H9X60_RS10765	COG0601	transmembrane transport
H9X60_RS10770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9X60_RS10780	COG4608	Belongs to the ABC transporter superfamily
H9X60_RS10790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9X60_RS10800	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9X60_RS10815	COG2917	probably involved in intracellular septation
H9X60_RS10830	COG3047	cAMP biosynthetic process
H9X60_RS10835	COG2831	hemolysin activation secretion protein
H9X60_RS10840	COG3210	domain, Protein
H9X60_RS10845	COG0159	tryptophan synthase activity
H9X60_RS10850	COG0133	tryptophan synthase activity
H9X60_RS10855	COG0135	phosphoribosylanthranilate isomerase activity
H9X60_RS10855	COG0134	indole-3-glycerol-phosphate synthase activity
H9X60_RS10860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9X60_RS10860	COG0512	Glutamine amidotransferase of anthranilate synthase
H9X60_RS10865	COG0512	Glutamine amidotransferase of anthranilate synthase
H9X60_RS10865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9X60_RS10880	COG0009	L-threonylcarbamoyladenylate synthase
H9X60_RS10885	COG1187	pseudouridine synthase activity
H9X60_RS10890	COG3700	Belongs to the class B bacterial acid phosphatase family
H9X60_RS10895	COG3210	domain, Protein
H9X60_RS10900	COG3210	domain, Protein
H9X60_RS10905	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H9X60_RS10910	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS10915	COG0616	signal peptide processing
H9X60_RS10925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9X60_RS10935	COG3590	peptidase
H9X60_RS10940	COG0583	DNA-binding transcription factor activity
H9X60_RS10955	COG0113	porphobilinogen synthase activity
H9X60_RS10960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9X60_RS10965	COG0671	phosphoesterase, PA-phosphatase related
H9X60_RS10970	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H9X60_RS10975	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9X60_RS10980	COG0284	orotidine-5'-phosphate decarboxylase activity
H9X60_RS10985	COG0023	Translation Initiation Factor
H9X60_RS10995	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
H9X60_RS11005	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H9X60_RS11010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9X60_RS11020	COG4659	FMN binding
H9X60_RS11030	COG4656	Part of a membrane complex involved in electron transport
H9X60_RS11040	COG4657	Part of a membrane complex involved in electron transport
H9X60_RS11050	COG0673	inositol 2-dehydrogenase activity
H9X60_RS11055	COG0385	Bile acid
H9X60_RS11060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9X60_RS11065	COG5339	Protein conserved in bacteria
H9X60_RS11070	COG1482	cell wall glycoprotein biosynthetic process
H9X60_RS11075	COG0114	fumarate hydratase activity
H9X60_RS11085	COG3397	chitin binding
H9X60_RS11090	COG2814	Major facilitator Superfamily
H9X60_RS11095	COG0583	DNA-binding transcription factor activity
H9X60_RS11100	COG1940	carbohydrate kinase activity
H9X60_RS11105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9X60_RS11130	COG1802	Transcriptional regulator
H9X60_RS11145	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H9X60_RS11150	COG1280	lysine exporter protein (LysE YggA)
H9X60_RS11155	COG1671	Belongs to the UPF0178 family
H9X60_RS11170	COG1309	transcriptional regulator
H9X60_RS11190	COG0697	spore germination
H9X60_RS11195	COG1846	Transcriptional regulator
H9X60_RS11205	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H9X60_RS11215	COG0714	Associated with various cellular activities
H9X60_RS11220	COG3831	ATPase activity
H9X60_RS11225	COG0251	oxidation-reduction process
H9X60_RS11255	COG1073	alpha beta
H9X60_RS11255	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H9X60_RS11255	COG3064	Membrane
H9X60_RS11260	COG1979	alcohol dehydrogenase
H9X60_RS11265	COG2814	Major facilitator Superfamily
H9X60_RS11270	COG2814	Major facilitator Superfamily
H9X60_RS11275	COG2211	Major facilitator Superfamily
H9X60_RS11280	COG2169	Transcriptional regulator
H9X60_RS11280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9X60_RS11300	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H9X60_RS11305	COG3097	Belongs to the UPF0267 family
H9X60_RS11325	COG2223	nitrite transmembrane transporter activity
H9X60_RS11345	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9X60_RS11360	COG1051	belongs to the nudix hydrolase family
H9X60_RS11380	COG4807	Protein conserved in bacteria
H9X60_RS11385	COG5642	Protein of unknown function (DUF2384)
H9X60_RS11390	COG5654	RES domain protein
H9X60_RS11395	COG0583	DNA-binding transcription factor activity
H9X60_RS11400	COG0825	malonyl-CoA metabolic process
H9X60_RS11415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9X60_RS11430	COG0765	amino acid transport
H9X60_RS11435	COG1126	abc transporter atp-binding protein
H9X60_RS11460	COG1403	HNH endonuclease
H9X60_RS11545	COG5301	cellulose 1,4-beta-cellobiosidase activity
H9X60_RS11590	COG3772	lysozyme
H9X60_RS11630	COG4695	Portal protein
H9X60_RS11685	COG4974	Belongs to the 'phage' integrase family
H9X60_RS11690	COG3634	alkyl hydroperoxide reductase activity
H9X60_RS11700	COG0842	Transport permease protein
H9X60_RS11705	COG0842	Transport permease protein
H9X60_RS11705	COG1129	ABC transporter
H9X60_RS11710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9X60_RS11720	COG0488	(ABC) transporter
H9X60_RS11735	COG0814	amino acid
H9X60_RS11745	COG0604	alcohol dehydrogenase
H9X60_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS11745	COG3321	synthase
H9X60_RS11750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9X60_RS11755	COG0589	response to stress
H9X60_RS11760	COG1309	transcriptional regulator
H9X60_RS11770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9X60_RS11775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9X60_RS11785	COG0531	amino acid
H9X60_RS11790	COG1643	Atp-dependent helicase
H9X60_RS11800	COG3784	Protein of unknown function (DUF1318)
H9X60_RS11810	COG2911	Protein conserved in bacteria
H9X60_RS11815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9X60_RS11825	COG2999	glutathione oxidoreductase activity
H9X60_RS11860	COG3042	response to heat
H9X60_RS11870	COG2983	Belongs to the UPF0260 family
H9X60_RS11875	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9X60_RS11880	COG2951	lytic endotransglycosylase activity
H9X60_RS11885	COG3100	YcgL domain-containing protein
H9X60_RS11890	COG0850	regulation of cytokinetic process
H9X60_RS11895	COG2894	cell division
H9X60_RS11900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H9X60_RS11930	COG0318	PFAM AMP-dependent synthetase and ligase
H9X60_RS11935	COG3065	identical protein binding
H9X60_RS11945	COG1199	ATP-dependent helicase activity
H9X60_RS11950	COG0251	oxidation-reduction process
H9X60_RS11955	COG2076	Multidrug Resistance protein
H9X60_RS11960	COG2076	Multidrug Resistance protein
H9X60_RS11970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9X60_RS11975	COG1737	Transcriptional regulator
H9X60_RS11980	COG0469	pyruvate kinase activity
H9X60_RS11990	COG3188	usher protein
H9X60_RS12005	COG0583	DNA-binding transcription factor activity
H9X60_RS12010	COG1560	Kdo2-lipid A biosynthetic process
H9X60_RS12015	COG0739	heme binding
H9X60_RS12020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H9X60_RS12025	COG1121	(ABC) transporter
H9X60_RS12030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9X60_RS12035	COG2255	four-way junction helicase activity
H9X60_RS12040	COG0632	four-way junction helicase activity
H9X60_RS12045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9X60_RS12050	COG0217	transcriptional regulatory protein
H9X60_RS12055	COG0494	nUDIX hydrolase
H9X60_RS12060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9X60_RS12075	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H9X60_RS12080	COG2226	methyltransferase
H9X60_RS12085	COG0500	methyltransferase
H9X60_RS12090	COG3302	dmso reductase anchor subunit
H9X60_RS12095	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS12100	COG0243	molybdopterin cofactor binding
H9X60_RS12105	COG3142	Participates in the control of copper homeostasis
H9X60_RS12110	COG3102	Protein conserved in bacteria
H9X60_RS12115	COG0018	arginyl-trna synthetase
H9X60_RS12135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9X60_RS12140	COG0477	Major facilitator Superfamily
H9X60_RS12150	COG3381	protein complex oligomerization
H9X60_RS12155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9X60_RS12165	COG1115	amino acid carrier protein
H9X60_RS12170	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS12175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9X60_RS12180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9X60_RS12190	COG4977	sequence-specific DNA binding
H9X60_RS12195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9X60_RS12200	COG2267	carboxylic ester hydrolase activity
H9X60_RS12205	COG0671	phosphoesterase, PA-phosphatase related
H9X60_RS12205	COG2453	phosphatase
H9X60_RS12215	COG0659	secondary active sulfate transmembrane transporter activity
H9X60_RS12225	COG1242	4 iron, 4 sulfur cluster binding
H9X60_RS12415	COG2890	protein-(glutamine-N5) methyltransferase activity
H9X60_RS12420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9X60_RS12425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9X60_RS12430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H9X60_RS12435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9X60_RS12440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9X60_RS12450	COG0193	aminoacyl-tRNA hydrolase activity
H9X60_RS12455	COG0012	GTP binding
H9X60_RS12475	COG3188	usher protein
H9X60_RS12500	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H9X60_RS12505	COG0583	DNA-binding transcription factor activity
H9X60_RS12510	COG3961	Belongs to the TPP enzyme family
H9X60_RS12525	COG1288	antiporter activity
H9X60_RS12540	COG4772	TonB-dependent receptor
H9X60_RS12550	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS12555	COG0243	molybdopterin cofactor binding
H9X60_RS12575	COG1280	lysine exporter protein (LysE YggA)
H9X60_RS12585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9X60_RS12590	COG1271	oxidase subunit
H9X60_RS12595	COG1294	oxidase, subunit
H9X60_RS12610	COG2375	cellular response to nickel ion
H9X60_RS12615	COG3443	Belongs to the bacterial solute-binding protein 9 family
H9X60_RS12620	COG1702	phosphate starvation-inducible protein PhoH
H9X60_RS12625	COG2356	endonuclease I
H9X60_RS12630	COG3610	response to peptide
H9X60_RS12635	COG2966	Psort location CytoplasmicMembrane, score
H9X60_RS12655	COG0589	response to stress
H9X60_RS12665	COG0589	response to stress
H9X60_RS12675	COG0673	inositol 2-dehydrogenase activity
H9X60_RS12680	COG0791	NLP P60 protein
H9X60_RS12695	COG1794	racemase activity, acting on amino acids and derivatives
H9X60_RS12720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9X60_RS12725	COG0037	tRNA processing
H9X60_RS12730	COG0598	Magnesium transport protein CorA
H9X60_RS12735	COG4166	transmembrane transport
H9X60_RS12755	COG3768	UPF0283 membrane protein
H9X60_RS12760	COG3106	COG3106 Predicted ATPase
H9X60_RS12765	COG1983	PspC domain protein
H9X60_RS12775	COG1842	Phage shock protein A
H9X60_RS12780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9X60_RS12790	COG4166	transmembrane transport
H9X60_RS12800	COG4171	peptide transport system, permease
H9X60_RS12810	COG4172	Belongs to the ABC transporter superfamily
H9X60_RS12815	COG3739	integral membrane protein
H9X60_RS12825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9X60_RS12830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9X60_RS12835	COG0259	pyridoxamine-phosphate oxidase activity
H9X60_RS12840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9X60_RS12845	COG3133	Outer membrane lipoprotein
H9X60_RS12850	COG1846	Transcriptional regulator
H9X60_RS12855	COG3313	Fe-S protein
H9X60_RS12860	COG0346	lactoylglutathione lyase activity
H9X60_RS12865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9X60_RS12870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9X60_RS12880	COG1609	Transcriptional regulator
H9X60_RS12885	COG0583	DNA-binding transcription factor activity
H9X60_RS12890	COG2814	Major facilitator Superfamily
H9X60_RS12905	COG0307	riboflavin synthase, alpha
H9X60_RS12910	COG0534	Mate efflux family protein
H9X60_RS12930	COG0469	pyruvate kinase activity
H9X60_RS12935	COG4238	major outer membrane lipoprotein
H9X60_RS12940	COG1376	ErfK ybiS ycfS ynhG family protein
H9X60_RS12940	COG1388	LysM domain
H9X60_RS12945	COG2166	iron-sulfur cluster assembly
H9X60_RS12950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9X60_RS12955	COG0719	Fe-S assembly protein
H9X60_RS12960	COG0396	ATPase activity
H9X60_RS12965	COG0719	Fe-S assembly protein
H9X60_RS12970	COG0316	Belongs to the HesB IscA family
H9X60_RS12975	COG2050	protein possibly involved in aromatic compounds catabolism
H9X60_RS12980	COG0277	FAD linked oxidase domain protein
H9X60_RS12980	COG0247	lactate metabolic process
H9X60_RS12985	COG0628	permease
H9X60_RS12990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9X60_RS12990	COG0574	Belongs to the PEP-utilizing enzyme family
H9X60_RS12995	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9X60_RS13010	COG3720	iron ion transport
H9X60_RS13015	COG2207	Transcriptional regulator
H9X60_RS13025	COG0791	NLP P60 protein
H9X60_RS13030	COG2076	Multidrug Resistance protein
H9X60_RS13035	COG2076	Multidrug Resistance protein
H9X60_RS13040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9X60_RS13045	COG0726	polysaccharide deacetylase
H9X60_RS13050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9X60_RS13050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9X60_RS13055	COG0463	Glycosyl transferase, family 2
H9X60_RS13060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9X60_RS13065	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H9X60_RS13080	COG0776	regulation of translation
H9X60_RS13085	COG0072	phenylalanine-tRNA ligase activity
H9X60_RS13085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9X60_RS13090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9X60_RS13100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9X60_RS13105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9X60_RS13115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9X60_RS13120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9X60_RS13155	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9X60_RS13160	COG1121	(ABC) transporter
H9X60_RS13165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9X60_RS13170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9X60_RS13180	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H9X60_RS13180	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H9X60_RS13185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9X60_RS13190	COG0542	response to heat
H9X60_RS13195	COG3001	Fructosamine kinase
H9X60_RS13205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9X60_RS13210	COG1988	membrane-bound metal-dependent
H9X60_RS13215	COG1823	symporter activity
H9X60_RS13220	COG0727	PFAM Uncharacterised protein family (UPF0153)
H9X60_RS13225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9X60_RS13235	COG3422	double-strand break repair
H9X60_RS13260	COG1473	amidohydrolase
H9X60_RS13280	COG1070	Carbohydrate kinase
H9X60_RS13285	COG0246	Mannitol dehydrogenase
H9X60_RS13300	COG2390	Transcriptional regulator
H9X60_RS13305	COG1461	Dihydroxyacetone kinase
H9X60_RS13310	COG2376	Dihydroxyacetone kinase
H9X60_RS13315	COG2814	Major facilitator Superfamily
H9X60_RS13320	COG1063	alcohol dehydrogenase
H9X60_RS13325	COG0698	ribose 5-phosphate isomerase
H9X60_RS13330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9X60_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS13340	COG4619	ABC transporter
H9X60_RS13345	COG0390	transport system, permease component
H9X60_RS13360	COG1069	ribulokinase activity
H9X60_RS13380	COG1609	Transcriptional regulator
H9X60_RS13395	COG3037	sugar-specific permease SgaT UlaA
H9X60_RS13405	COG1683	Conserved Protein
H9X60_RS13440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9X60_RS13445	COG1349	DNA-binding transcription factor activity
H9X60_RS13450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9X60_RS13490	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9X60_RS13525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9X60_RS13530	COG0322	excinuclease ABC activity
H9X60_RS13535	COG2197	response regulator
H9X60_RS13540	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9X60_RS13545	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9X60_RS13580	COG1494	fructose-1,6-bisphosphatase
H9X60_RS13595	COG4565	transcriptional regulatory protein
H9X60_RS13600	COG3290	protein histidine kinase activity
H9X60_RS13605	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H9X60_RS13615	COG2301	Belongs to the HpcH HpaI aldolase family
H9X60_RS13620	COG3051	citrate lyase alpha subunit
H9X60_RS13635	COG0471	metal ion transport
H9X60_RS13640	COG2828	Protein conserved in bacteria
H9X60_RS13655	COG2720	vancomycin resistance protein
H9X60_RS13660	COG2851	Citrate transporter
H9X60_RS13665	COG1902	pentaerythritol trinitrate reductase activity
H9X60_RS13685	COG0471	metal ion transport
H9X60_RS13695	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H9X60_RS13700	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS13705	COG1309	transcriptional regulator
H9X60_RS13710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9X60_RS13725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS13730	COG0800	Aldolase
H9X60_RS13760	COG3210	domain, Protein
H9X60_RS13780	COG1191	sigma factor activity
H9X60_RS13810	COG0242	peptide deformylase activity
H9X60_RS13830	COG5510	response to toxic substance
H9X60_RS13840	COG1278	Cold shock
H9X60_RS13850	COG1677	Flagellar hook-basal body complex protein FliE
H9X60_RS13855	COG1766	The M ring may be actively involved in energy transduction
H9X60_RS13865	COG1317	bacterial-type flagellum organization
H9X60_RS13875	COG2882	bacterial-type flagellum organization
H9X60_RS13885	COG1580	Controls the rotational direction of flagella during chemotaxis
H9X60_RS13895	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9X60_RS13945	COG1706	bacterial-type flagellum-dependent cell motility
H9X60_RS13950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9X60_RS13970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H9X60_RS13975	COG1558	bacterial-type flagellum-dependent cell motility
H9X60_RS13980	COG1815	bacterial-type flagellum-dependent cell motility
H9X60_RS14010	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9X60_RS14040	COG0745	RESPONSE REGULATOR receiver
H9X60_RS14045	COG2201	protein-glutamate methylesterase activity
H9X60_RS14050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9X60_RS14055	COG0840	transmembrane signaling receptor activity
H9X60_RS14065	COG0835	chemotaxis
H9X60_RS14095	COG1598	PFAM Uncharacterised protein family UPF0150
H9X60_RS14110	COG1113	amino acid transport
H9X60_RS14120	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H9X60_RS14120	COG0506	proline dehydrogenase activity
H9X60_RS14120	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H9X60_RS14140	COG1285	pathogenesis
H9X60_RS14180	COG0418	dihydroorotase activity
H9X60_RS14195	COG0071	Belongs to the small heat shock protein (HSP20) family
H9X60_RS14200	COG1054	Belongs to the UPF0176 family
H9X60_RS14205	COG3683	transport system, periplasmic component
H9X60_RS14210	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H9X60_RS14240	COG1560	Kdo2-lipid A biosynthetic process
H9X60_RS14245	COG2814	Major facilitator Superfamily
H9X60_RS14270	COG1607	acyl-coa hydrolase
H9X60_RS14285	COG0519	Catalyzes the synthesis of GMP from XMP
H9X60_RS14295	COG0456	acetyltransferase
H9X60_RS14305	COG2864	formate dehydrogenase
H9X60_RS14310	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS14320	COG1742	UPF0060 membrane protein
H9X60_RS14345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9X60_RS14355	COG2005	Transcriptional regulator
H9X60_RS14355	COG3585	molybdate ion transport
H9X60_RS14370	COG2388	GCN5-related N-acetyl-transferase
H9X60_RS14495	COG3209	COG3209 Rhs family protein
H9X60_RS14505	COG3501	Rhs element vgr protein
H9X60_RS14530	COG4608	Belongs to the ABC transporter superfamily
H9X60_RS14540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9X60_RS14545	COG4413	Urea transporter
H9X60_RS14550	COG0829	nickel cation binding
H9X60_RS14555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H9X60_RS14565	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H9X60_RS14570	COG0804	urea catabolic process
H9X60_RS14575	COG0832	Belongs to the urease beta subunit family
H9X60_RS14580	COG0831	urea catabolic process
H9X60_RS14590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9X60_RS14595	COG0601	transmembrane transport
H9X60_RS14600	COG0747	negative chemotaxis
H9X60_RS14605	COG0004	ammonium transporteR
H9X60_RS14765	COG0582	viral genome integration into host DNA
H9X60_RS14775	COG2920	part of a sulfur-relay system
H9X60_RS14780	COG1254	Belongs to the acylphosphatase family
H9X60_RS14785	COG3785	DNA binding
H9X60_RS14790	COG1832	CoA-binding protein
H9X60_RS14795	COG1803	Methylglyoxal synthase
H9X60_RS14800	COG0210	DNA helicase
H9X60_RS14805	COG1289	transmembrane transporter activity
H9X60_RS14810	COG3070	regulator of competence-specific genes
H9X60_RS14815	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
H9X60_RS14835	COG1067	ATP-dependent peptidase activity
H9X60_RS14845	COG3130	regulation of translation
H9X60_RS14850	COG3009	Protein conserved in bacteria
H9X60_RS14855	COG3008	intermembrane lipid transfer
H9X60_RS14855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9X60_RS14860	COG2995	paraquat-inducible protein a
H9X60_RS14865	COG0488	(ABC) transporter
H9X60_RS14870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9X60_RS14870	COG0116	Belongs to the methyltransferase superfamily
H9X60_RS14875	COG3217	Mosc domain protein beta barrel domain protein
H9X60_RS14875	COG0633	Ferredoxin
H9X60_RS14885	COG0167	dihydroorotate dehydrogenase activity
H9X60_RS14890	COG0308	aminopeptidase N
H9X60_RS14895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9X60_RS14900	COG0017	Asparaginyl-tRNA synthetase
H9X60_RS14905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9X60_RS14910	COG1448	Aminotransferase
H9X60_RS14915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9X60_RS14920	COG3108	Peptidase M15
H9X60_RS14925	COG2989	Protein conserved in bacteria
H9X60_RS14935	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H9X60_RS14940	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H9X60_RS14945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9X60_RS14950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9X60_RS14955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9X60_RS14970	COG1663	tetraacyldisaccharide 4'-kinase activity
H9X60_RS14975	COG1132	(ABC) transporter
H9X60_RS14980	COG2333	competence protein COMEC
H9X60_RS14980	COG0658	competence protein
H9X60_RS14990	COG0776	regulation of translation
H9X60_RS14995	COG0539	negative regulation of cytoplasmic translation
H9X60_RS15000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9X60_RS15005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9X60_RS15010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9X60_RS15015	COG0033	Phosphoglucomutase
H9X60_RS15020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H9X60_RS15025	COG0596	Alpha beta hydrolase
H9X60_RS15030	COG2274	protein secretion by the type I secretion system
H9X60_RS15050	COG0716	FMN binding
H9X60_RS15055	COG0735	belongs to the Fur family
H9X60_RS15070	COG0252	asparaginase activity
H9X60_RS15075	COG1944	ATP diphosphatase activity
H9X60_RS15080	COG2721	sulfolactate sulfo-lyase activity
H9X60_RS15085	COG2271	Major facilitator Superfamily
H9X60_RS15090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9X60_RS15095	COG1414	Transcriptional regulator
H9X60_RS15100	COG2116	formate transmembrane transporter activity
H9X60_RS15105	COG1882	Formate acetyltransferase
H9X60_RS15110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9X60_RS15130	COG0583	DNA-binding transcription factor activity
H9X60_RS15140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9X60_RS15145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9X60_RS15150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H9X60_RS15155	COG3107	peptidoglycan biosynthetic process
H9X60_RS15155	COG1674	ftsk spoiiie
H9X60_RS15160	COG1522	sequence-specific DNA binding
H9X60_RS15165	COG0492	ferredoxin-NADP+ reductase activity
H9X60_RS15170	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H9X60_RS15180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9X60_RS15185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9X60_RS15190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9X60_RS15195	COG0542	response to heat
H9X60_RS15200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9X60_RS15205	COG1278	Cold shock
H9X60_RS15215	COG1414	Transcriptional regulator
H9X60_RS15220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9X60_RS15220	COG3153	acetyltransferase
H9X60_RS15230	COG2186	Transcriptional regulator
H9X60_RS15235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9X60_RS15235	COG0473	3-isopropylmalate dehydrogenase activity
H9X60_RS15240	COG2271	Major facilitator Superfamily
H9X60_RS15250	COG1136	(ABC) transporter
H9X60_RS15250	COG0577	efflux transmembrane transporter activity
H9X60_RS15255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9X60_RS15260	COG3593	DNA synthesis involved in DNA repair
H9X60_RS15265	COG2431	L-lysine efflux transmembrane transporter activity
H9X60_RS15270	COG0702	epimerase
H9X60_RS15275	COG1126	abc transporter atp-binding protein
H9X60_RS15280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9X60_RS15285	COG4215	(ABC) transporter
H9X60_RS15290	COG4160	amino acid transport
H9X60_RS15300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9X60_RS15320	COG0432	Pfam Uncharacterised protein family UPF0047
H9X60_RS15325	COG0671	phosphoesterase, PA-phosphatase related
H9X60_RS15330	COG0814	amino acid
H9X60_RS15335	COG1760	l-serine dehydratase
H9X60_RS15340	COG1686	Belongs to the peptidase S11 family
H9X60_RS15345	COG0625	glutathione transferase activity
H9X60_RS15350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9X60_RS15360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9X60_RS15360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9X60_RS15365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9X60_RS15365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9X60_RS15370	COG0131	Imidazoleglycerol-phosphate dehydratase
H9X60_RS15370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9X60_RS15380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9X60_RS15385	COG0107	imidazoleglycerol-phosphate synthase activity
H9X60_RS15390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9X60_RS15390	COG0140	phosphoribosyl-ATP diphosphatase activity
H9X60_RS15405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9X60_RS15430	COG1253	flavin adenine dinucleotide binding
H9X60_RS15440	COG2982	Protein involved in outer membrane biogenesis
H9X60_RS15445	COG0717	Belongs to the dCTP deaminase family
H9X60_RS15450	COG0572	uridine kinase
H9X60_RS15455	COG0501	Belongs to the peptidase M48B family
H9X60_RS15465	COG0489	protein tyrosine kinase activity
H9X60_RS15470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9X60_RS15470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9X60_RS15475	COG1380	Effector of murein hydrolase LrgA
H9X60_RS15480	COG1346	cytolysis
H9X60_RS15535	COG0281	malic enzyme
H9X60_RS15555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS15555	COG1263	PTS System
H9X60_RS15570	COG2949	membrane
H9X60_RS15575	COG2311	Membrane
H9X60_RS15580	COG0302	gtp cyclohydrolase
H9X60_RS15585	COG0303	'Molybdopterin
H9X60_RS15590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9X60_RS15595	COG2824	Alkylphosphonate utilization operon protein PhnA
H9X60_RS15600	COG0488	(ABC) transporter
H9X60_RS15615	COG5006	permease, DMT superfamily
H9X60_RS15635	COG2897	thiosulfate sulfurtransferase activity
H9X60_RS15640	COG2261	transglycosylase associated protein
H9X60_RS15645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9X60_RS15650	COG0513	Belongs to the DEAD box helicase family
H9X60_RS15655	COG1309	transcriptional regulator
H9X60_RS15665	COG1131	(ABC) transporter
H9X60_RS15670	COG0842	Transport permease protein
H9X60_RS15675	COG0842	Transport permease protein
H9X60_RS15680	COG0670	Belongs to the BI1 family
H9X60_RS15685	COG0314	molybdopterin synthase activity
H9X60_RS15690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9X60_RS15700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9X60_RS15710	COG0556	nucleotide-excision repair
H9X60_RS15720	COG2226	methyltransferase
H9X60_RS15730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9X60_RS15740	COG2706	6-phosphogluconolactonase activity
H9X60_RS15745	COG0561	phosphatase activity
H9X60_RS15755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9X60_RS15765	COG0477	Major facilitator Superfamily
H9X60_RS15770	COG0246	Mannitol dehydrogenase
H9X60_RS15775	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H9X60_RS15780	COG4149	molybdate abc transporter
H9X60_RS15785	COG0725	ABC transporter, periplasmic molybdate-binding protein
H9X60_RS15800	COG2005	Transcriptional regulator
H9X60_RS15800	COG3585	molybdate ion transport
H9X60_RS15805	COG1119	ATPase activity
H9X60_RS15825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9X60_RS15825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS15825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS15825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS15825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9X60_RS15825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS15830	COG0383	alpha-mannosidase activity
H9X60_RS15835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9X60_RS15835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9X60_RS15835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9X60_RS15840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9X60_RS15850	COG0588	phosphoglycerate mutase activity
H9X60_RS15865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9X60_RS15875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9X60_RS15900	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H9X60_RS15905	COG2885	chlorophyll binding
H9X60_RS15910	COG0823	Involved in the tonB-independent uptake of proteins
H9X60_RS15915	COG3064	Membrane
H9X60_RS15920	COG0848	biopolymer transport protein
H9X60_RS15925	COG0811	peptide transport
H9X60_RS15930	COG0824	Thioesterase
H9X60_RS15940	COG4890	Cyd operon protein YbgT
H9X60_RS15945	COG1294	oxidase, subunit
H9X60_RS15950	COG1271	oxidase subunit
H9X60_RS15955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9X60_RS15960	COG0045	succinate-CoA ligase (ADP-forming) activity
H9X60_RS15965	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9X60_RS15970	COG0567	Dehydrogenase, E1 component
H9X60_RS15980	COG1053	succinate dehydrogenase
H9X60_RS15985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H9X60_RS16005	COG2814	Major facilitator Superfamily
H9X60_RS16010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H9X60_RS16055	COG3675	Pfam Lipase (class 3)
H9X60_RS16065	COG3501	Rhs element vgr protein
H9X60_RS16080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9X60_RS16100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H9X60_RS16105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H9X60_RS16110	COG2205	protein histidine kinase activity
H9X60_RS16115	COG0745	RESPONSE REGULATOR receiver
H9X60_RS16125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9X60_RS16145	COG2190	(PTS) system
H9X60_RS16145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS16145	COG1263	PTS System
H9X60_RS16150	COG0363	glucosamine-6-phosphate deaminase activity
H9X60_RS16155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9X60_RS16160	COG1846	Transcriptional regulator
H9X60_RS16160	COG1940	carbohydrate kinase activity
H9X60_RS16195	COG1301	dicarboxylic acid transport
H9X60_RS16200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9X60_RS16205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9X60_RS16210	COG1702	phosphate starvation-inducible protein PhoH
H9X60_RS16215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9X60_RS16220	COG4535	Mg2 and Co2 transporter CorC
H9X60_RS16225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9X60_RS16250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9X60_RS16255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9X60_RS16255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9X60_RS16275	COG0765	amino acid transport
H9X60_RS16280	COG0765	amino acid transport
H9X60_RS16285	COG1126	abc transporter atp-binding protein
H9X60_RS16290	COG0495	leucyl-tRNA aminoacylation
H9X60_RS16295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H9X60_RS16300	COG1466	dna polymerase III delta subunit
H9X60_RS16315	COG0799	negative regulation of ribosome biogenesis
H9X60_RS16320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9X60_RS16325	COG0768	penicillin binding
H9X60_RS16330	COG0772	Belongs to the SEDS family
H9X60_RS16335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9X60_RS16340	COG1686	Belongs to the peptidase S11 family
H9X60_RS16345	COG2921	Belongs to the UPF0250 family
H9X60_RS16350	COG0321	lipoyl(octanoyl) transferase activity
H9X60_RS16355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9X60_RS16360	COG1278	Cold shock
H9X60_RS16365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9X60_RS16375	COG1780	Probably involved in ribonucleotide reductase function
H9X60_RS16390	COG4175	Glycine betaine
H9X60_RS16395	COG4176	ABC-type proline glycine betaine transport system permease component
H9X60_RS16400	COG2113	Glycine betaine
H9X60_RS16405	COG2814	Major facilitator Superfamily
H9X60_RS16410	COG1846	Transcriptional regulator
H9X60_RS16415	COG1566	PFAM secretion protein HlyD family protein
H9X60_RS16420	COG2814	Major facilitator Superfamily
H9X60_RS16425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9X60_RS16430	COG3148	PFAM DTW domain containing protein
H9X60_RS16440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9X60_RS16445	COG5544	Lipoprotein
H9X60_RS16460	COG0640	Transcriptional regulator
H9X60_RS16495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9X60_RS16500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9X60_RS16505	COG2011	ABC-type metal ion transport system permease component
H9X60_RS16510	COG1464	Belongs to the NlpA lipoprotein family
H9X60_RS16520	COG1720	tRNA m6t6A37 methyltransferase activity
H9X60_RS16525	COG0442	prolyl-tRNA aminoacylation
H9X60_RS16535	COG1486	melibiose metabolic process
H9X60_RS16540	COG2169	Transcriptional regulator
H9X60_RS16540	COG1917	Cupin 2, conserved barrel domain protein
H9X60_RS16545	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9X60_RS16550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9X60_RS16555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9X60_RS16560	COG3015	lipoprotein NlpE involved in copper resistance
H9X60_RS16565	COG4568	rho-dependent transcription termination
H9X60_RS16570	COG0037	tRNA processing
H9X60_RS16590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9X60_RS16595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9X60_RS16600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9X60_RS16605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9X60_RS16610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9X60_RS16620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9X60_RS16625	COG0750	zinc metalloprotease
H9X60_RS16630	COG0575	Belongs to the CDS family
H9X60_RS16635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9X60_RS16640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9X60_RS16645	COG0233	cytoplasmic translational termination
H9X60_RS16650	COG0528	UMP kinase activity
H9X60_RS16655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9X60_RS16670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9X60_RS16685	COG0716	FMN binding
H9X60_RS16690	COG0564	pseudouridine synthase activity
H9X60_RS16695	COG3098	single-species biofilm formation
H9X60_RS16715	COG1611	Belongs to the LOG family
H9X60_RS16730	COG2363	Small membrane protein
H9X60_RS16735	COG0583	DNA-binding transcription factor activity
H9X60_RS16740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9X60_RS16745	COG2166	iron-sulfur cluster assembly
H9X60_RS16750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9X60_RS16755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H9X60_RS16775	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9X60_RS16780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9X60_RS16780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9X60_RS16790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9X60_RS16795	COG1074	ATP-dependent DNA helicase activity
H9X60_RS16805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H9X60_RS16820	COG4795	General secretion pathway protein
H9X60_RS16830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9X60_RS16835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9X60_RS16845	COG0494	nUDIX hydrolase
H9X60_RS16850	COG4143	(ABC) transporter
H9X60_RS16855	COG1178	ABC-type Fe3 transport system permease component
H9X60_RS16860	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H9X60_RS16865	COG0417	DNA replication proofreading
H9X60_RS16870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9X60_RS16875	COG0564	pseudouridine synthase activity
H9X60_RS16880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9X60_RS16885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9X60_RS16890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9X60_RS16895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9X60_RS16900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9X60_RS16905	COG2967	ApaG domain
H9X60_RS16910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9X60_RS16915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9X60_RS16920	COG1280	lysine exporter protein (LysE YggA)
H9X60_RS16925	COG2132	Multicopper oxidase
H9X60_RS16930	COG0204	Acyl-transferase
H9X60_RS16940	COG0187	DNA topoisomerase II activity
H9X60_RS16945	COG3150	esterase
H9X60_RS16950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H9X60_RS16955	COG0494	nUDIX hydrolase
H9X60_RS16965	COG5463	Belongs to the UPF0441 family
H9X60_RS16970	COG0754	glutathionylspermidine amidase activity
H9X60_RS16975	COG3384	dioxygenase
H9X60_RS16980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9X60_RS16995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H9X60_RS16995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9X60_RS17000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9X60_RS17005	COG3025	triphosphatase activity
H9X60_RS17010	COG4991	sh3 domain protein
H9X60_RS17015	COG0617	tRNA 3'-terminal CCA addition
H9X60_RS17020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9X60_RS17025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9X60_RS17030	COG0840	transmembrane signaling receptor activity
H9X60_RS17035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9X60_RS17040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9X60_RS17045	COG0358	DNA primase activity
H9X60_RS17060	COG2814	Major facilitator Superfamily
H9X60_RS17075	COG2271	Major facilitator Superfamily
H9X60_RS17085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9X60_RS17110	COG2226	methyltransferase
H9X60_RS17120	COG1120	ATPase activity
H9X60_RS17150	COG1124	(ABC) transporter
H9X60_RS17160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9X60_RS17200	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H9X60_RS17205	COG0830	nickel cation binding
H9X60_RS17215	COG0309	Hydrogenase expression formation protein (HypE)
H9X60_RS17220	COG0409	Hydrogenase expression formation protein
H9X60_RS17225	COG0298	carbon dioxide binding
H9X60_RS17230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H9X60_RS17240	COG1773	rubredoxin
H9X60_RS17245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H9X60_RS17250	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H9X60_RS17255	COG5557	Pfam Polysulphide reductase, NrfD
H9X60_RS17260	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS17265	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H9X60_RS17270	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H9X60_RS17290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9X60_RS17295	COG0641	radical SAM
H9X60_RS17300	COG0561	phosphatase activity
H9X60_RS17305	COG3711	transcriptional antiterminator
H9X60_RS17310	COG2190	(PTS) system
H9X60_RS17310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS17310	COG1263	PTS System
H9X60_RS17315	COG2723	6-phospho-beta-galactosidase activity
H9X60_RS17320	COG2146	nitrite reductase [NAD(P)H] activity
H9X60_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS17340	COG1414	Transcriptional regulator
H9X60_RS17355	COG2271	Major facilitator Superfamily
H9X60_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS17375	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H9X60_RS17380	COG1012	belongs to the aldehyde dehydrogenase family
H9X60_RS17390	COG0590	tRNA wobble adenosine to inosine editing
H9X60_RS17460	COG3501	Rhs element vgr protein
H9X60_RS17485	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9X60_RS17485	COG1902	pentaerythritol trinitrate reductase activity
H9X60_RS17490	COG1469	GTP cyclohydrolase I activity
H9X60_RS17500	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9X60_RS17505	COG0861	Integral membrane protein TerC family
H9X60_RS17510	COG0586	Pfam SNARE associated Golgi protein
H9X60_RS17515	COG4575	ribosome binding
H9X60_RS17520	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H9X60_RS17530	COG2259	Doxx family
H9X60_RS17535	COG0583	DNA-binding transcription factor activity
H9X60_RS17540	COG1741	Belongs to the pirin family
H9X60_RS17545	COG3711	transcriptional antiterminator
H9X60_RS17545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS17575	COG3964	amidohydrolase
H9X60_RS17590	COG0348	domain, Protein
H9X60_RS17600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9X60_RS17610	COG0792	nuclease activity
H9X60_RS17615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9X60_RS17620	COG2823	Periplasmic or secreted lipoprotein
H9X60_RS17625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9X60_RS17630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H9X60_RS17635	COG2198	Histidine kinase
H9X60_RS17635	COG0784	Response regulator, receiver
H9X60_RS17635	COG5002	protein histidine kinase activity
H9X60_RS17640	COG0493	'glutamate synthase
H9X60_RS17645	COG2969	positive regulation of protein catabolic process
H9X60_RS17650	COG0625	glutathione transferase activity
H9X60_RS17655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9X60_RS17660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9X60_RS17665	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9X60_RS17670	COG3105	Protein conserved in bacteria
H9X60_RS17675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9X60_RS17680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9X60_RS17685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9X60_RS17690	COG5007	Belongs to the BolA IbaG family
H9X60_RS17700	COG2854	intermembrane phospholipid transfer
H9X60_RS17705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9X60_RS17710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9X60_RS17715	COG1127	ABC transporter
H9X60_RS17720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9X60_RS17720	COG0517	IMP dehydrogenase activity
H9X60_RS17725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H9X60_RS17730	COG3117	lipopolysaccharide transmembrane transporter activity
H9X60_RS17735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H9X60_RS17740	COG1137	ATPase activity
H9X60_RS17745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H9X60_RS17750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9X60_RS17760	COG1660	Displays ATPase and GTPase activities
H9X60_RS17765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS17770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9X60_RS17775	COG0312	modulator of DNA gyrase
H9X60_RS17780	COG3028	Belongs to the UPF0307 family
H9X60_RS17800	COG2732	(Barnase) inhibitor
H9X60_RS17810	COG0312	modulator of DNA gyrase
H9X60_RS17815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9X60_RS17820	COG3164	Protein of unknown function
H9X60_RS17830	COG0424	maF-like protein
H9X60_RS17835	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H9X60_RS17840	COG1792	Involved in formation and maintenance of cell shape
H9X60_RS17845	COG1077	Cell shape determining protein MreB Mrl
H9X60_RS17850	COG0604	alcohol dehydrogenase
H9X60_RS17855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9X60_RS17860	COG0511	ligase activity, forming carbon-carbon bonds
H9X60_RS17865	COG0439	Biotin carboxylase
H9X60_RS17870	COG3924	membrane
H9X60_RS17875	COG4145	pantothenate transmembrane transporter activity
H9X60_RS17880	COG2264	protein methyltransferase activity
H9X60_RS17885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9X60_RS17890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9X60_RS17895	COG0840	transmembrane signaling receptor activity
H9X60_RS17900	COG4771	TonB-dependent receptor
H9X60_RS17910	COG0814	amino acid
H9X60_RS17960	COG2086	electron transfer activity
H9X60_RS17965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H9X60_RS17970	COG1960	acyl-CoA dehydrogenase activity
H9X60_RS17980	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9X60_RS18000	COG4177	L-phenylalanine transmembrane transporter activity
H9X60_RS18005	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9X60_RS18010	COG0683	leucine binding
H9X60_RS18015	COG0456	acetyltransferase
H9X60_RS18020	COG0346	lactoylglutathione lyase activity
H9X60_RS18030	COG2177	Part of the ABC transporter FtsEX involved in
H9X60_RS18035	COG2884	Cell division ATP-binding protein ftsE
H9X60_RS18040	COG0552	protein localization to endoplasmic reticulum
H9X60_RS18040	COG0552	protein localization to endoplasmic reticulum
H9X60_RS18045	COG0742	ribosomal rna small subunit methyltransferase
H9X60_RS18050	COG3776	membrane
H9X60_RS18060	COG3714	YhhN family
H9X60_RS18070	COG5464	transposase or invertase
H9X60_RS18080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9X60_RS18085	COG0247	lactate metabolic process
H9X60_RS18095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9X60_RS18100	COG2271	Major facilitator Superfamily
H9X60_RS18105	COG0584	glycerophosphoryl diester phosphodiesterase
H9X60_RS18115	COG1053	succinate dehydrogenase
H9X60_RS18120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9X60_RS18125	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9X60_RS18130	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9X60_RS18155	COG0477	Major facilitator Superfamily
H9X60_RS18165	COG3423	Transcriptional regulator
H9X60_RS18170	COG2076	Multidrug Resistance protein
H9X60_RS18180	COG1966	Carbon starvation protein
H9X60_RS18185	COG2879	small protein
H9X60_RS18190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9X60_RS18195	COG1509	lysine 2,3-aminomutase activity
H9X60_RS18210	COG3344	reverse transcriptase
H9X60_RS18230	COG1027	Aspartate ammonia-lyase
H9X60_RS18235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9X60_RS18245	COG1309	transcriptional regulator
H9X60_RS18280	COG0745	RESPONSE REGULATOR receiver
H9X60_RS18300	COG1177	transmembrane transport
H9X60_RS18315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H9X60_RS18315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H9X60_RS18330	COG3121	Chaperone
H9X60_RS18335	COG3188	usher protein
H9X60_RS18355	COG0583	DNA-binding transcription factor activity
H9X60_RS18360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9X60_RS18365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9X60_RS18390	COG3239	Fatty acid desaturase
H9X60_RS18395	COG0726	polysaccharide deacetylase
H9X60_RS18405	COG2271	Major facilitator Superfamily
H9X60_RS18420	COG2721	sulfolactate sulfo-lyase activity
H9X60_RS18435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9X60_RS18435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9X60_RS18445	COG3716	PTS system mannose fructose sorbose family IID component
H9X60_RS18460	COG1349	DNA-binding transcription factor activity
H9X60_RS18470	COG1129	ABC transporter
H9X60_RS18475	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9X60_RS18480	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9X60_RS18485	COG3623	hexulose-6-phosphate isomerase
H9X60_RS18490	COG1070	Carbohydrate kinase
H9X60_RS18495	COG2194	sulfuric ester hydrolase activity
H9X60_RS18505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS18510	COG2814	Major facilitator Superfamily
H9X60_RS18515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9X60_RS18525	COG1609	Transcriptional regulator
H9X60_RS18530	COG0583	DNA-binding transcription factor activity
H9X60_RS18535	COG2610	gluconate transmembrane transporter activity
H9X60_RS18540	COG3048	D-serine ammonia-lyase activity
H9X60_RS18545	COG1363	Peptidase, m42
H9X60_RS18550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9X60_RS18560	COG0444	Belongs to the ABC transporter superfamily
H9X60_RS18570	COG0747	negative chemotaxis
H9X60_RS18580	COG3573	Dehydrogenase
H9X60_RS18595	COG4604	ABC transporter, ATP-binding protein
H9X60_RS18600	COG4605	iron ion homeostasis
H9X60_RS18605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9X60_RS18610	COG4607	ABC-type enterochelin transport system periplasmic component
H9X60_RS18645	COG3121	Chaperone
H9X60_RS18650	COG3188	usher protein
H9X60_RS18665	COG3835	regulator
H9X60_RS18670	COG1929	Belongs to the glycerate kinase type-1 family
H9X60_RS18675	COG2271	Major facilitator Superfamily
H9X60_RS18685	COG1063	alcohol dehydrogenase
H9X60_RS18690	COG1830	Aldolase
H9X60_RS18695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9X60_RS18715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H9X60_RS18720	COG0800	Aldolase
H9X60_RS18730	COG1414	Transcriptional regulator
H9X60_RS18735	COG2181	nitrate reductase activity
H9X60_RS18740	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H9X60_RS18745	COG1140	nitrate reductase beta subunit
H9X60_RS18750	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H9X60_RS18755	COG2223	nitrite transmembrane transporter activity
H9X60_RS18760	COG3850	Histidine kinase
H9X60_RS18765	COG2197	response regulator
H9X60_RS18770	COG3835	regulator
H9X60_RS18775	COG1929	Belongs to the glycerate kinase type-1 family
H9X60_RS18785	COG0183	Belongs to the thiolase family
H9X60_RS18790	COG1028	Short-chain dehydrogenase reductase Sdr
H9X60_RS18800	COG0318	PFAM AMP-dependent synthetase and ligase
H9X60_RS18805	COG0625	glutathione transferase activity
H9X60_RS18810	COG1396	sequence-specific DNA binding
H9X60_RS18830	COG3188	usher protein
H9X60_RS18870	COG0318	PFAM AMP-dependent synthetase and ligase
H9X60_RS18870	COG0204	Acyl-transferase
H9X60_RS18875	COG1858	cytochrome C peroxidase
H9X60_RS18880	COG2211	Major facilitator Superfamily
H9X60_RS18885	COG1397	ADP-ribosylglycohydrolase
H9X60_RS18890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS18895	COG2188	Transcriptional regulator
H9X60_RS18905	COG3302	dmso reductase anchor subunit
H9X60_RS18910	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS18915	COG0243	molybdopterin cofactor binding
H9X60_RS18935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9X60_RS18940	COG1538	Outer membrane efflux protein
H9X60_RS18945	COG1136	(ABC) transporter
H9X60_RS18945	COG0577	efflux transmembrane transporter activity
H9X60_RS18950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9X60_RS18955	COG1132	(ABC) transporter
H9X60_RS18985	COG3539	Fimbrial protein
H9X60_RS18995	COG3121	Chaperone
H9X60_RS19000	COG3188	usher protein
H9X60_RS19010	COG3539	Fimbrial protein
H9X60_RS19030	COG2205	protein histidine kinase activity
H9X60_RS19035	COG0745	RESPONSE REGULATOR receiver
H9X60_RS19040	COG0582	viral genome integration into host DNA
H9X60_RS19050	COG1396	sequence-specific DNA binding
H9X60_RS19065	COG3188	usher protein
H9X60_RS19070	COG3121	Chaperone
H9X60_RS19115	COG3069	C4-dicarboxylate transmembrane transporter activity
H9X60_RS19120	COG1473	amidohydrolase
H9X60_RS19140	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H9X60_RS19150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9X60_RS19155	COG3829	transcription factor binding
H9X60_RS19165	COG1070	Carbohydrate kinase
H9X60_RS19170	COG4806	L-rhamnose isomerase
H9X60_RS19190	COG3254	rhamnose metabolic process
H9X60_RS19195	COG4977	sequence-specific DNA binding
H9X60_RS19195	COG1917	Cupin 2, conserved barrel domain protein
H9X60_RS19200	COG4977	sequence-specific DNA binding
H9X60_RS19210	COG3121	Chaperone
H9X60_RS19215	COG3188	usher protein
H9X60_RS19225	COG3069	C4-dicarboxylate transmembrane transporter activity
H9X60_RS19245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9X60_RS19250	COG0583	DNA-binding transcription factor activity
H9X60_RS19315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9X60_RS19330	COG0795	lipopolysaccharide-transporting ATPase activity
H9X60_RS19335	COG0795	lipopolysaccharide-transporting ATPase activity
H9X60_RS19340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9X60_RS19345	COG2927	DNA polymerase III (CHI subunit)
H9X60_RS19350	COG0525	valine-tRNA ligase activity
H9X60_RS19365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9X60_RS19370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9X60_RS19380	COG2188	Transcriptional regulator
H9X60_RS19410	COG0540	Belongs to the ATCase OTCase family
H9X60_RS19415	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H9X60_RS19420	COG0251	oxidation-reduction process
H9X60_RS19425	COG1328	CTP reductase activity
H9X60_RS19430	COG0602	queuosine metabolic process
H9X60_RS19435	COG3787	Belongs to the UPF0306 family
H9X60_RS19445	COG2827	Endonuclease containing a URI domain
H9X60_RS19450	COG3153	acetyltransferase
H9X60_RS19455	COG3154	lipid carrier protein
H9X60_RS19460	COG0826	peptidase U32
H9X60_RS19465	COG0826	peptidase U32
H9X60_RS19475	COG3077	Addiction module antitoxin, RelB DinJ family
H9X60_RS19495	COG3275	phosphorelay sensor kinase activity
H9X60_RS19515	COG0513	Belongs to the DEAD box helicase family
H9X60_RS19535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9X60_RS19540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9X60_RS19545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9X60_RS19550	COG0195	Participates in both transcription termination and antitermination
H9X60_RS19555	COG0779	Required for maturation of 30S ribosomal subunits
H9X60_RS19570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9X60_RS19575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9X60_RS19580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9X60_RS19585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9X60_RS19590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9X60_RS19595	COG1534	Rna-binding protein
H9X60_RS19605	COG2027	D-alanyl-D-alanine carboxypeptidase
H9X60_RS19610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9X60_RS19615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9X60_RS19620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9X60_RS19625	COG0142	geranyltranstransferase activity
H9X60_RS19640	COG3423	Transcriptional regulator
H9X60_RS19645	COG0626	cystathionine gamma-synthase activity
H9X60_RS19650	COG0814	amino acid
H9X60_RS19655	COG0583	DNA-binding transcription factor activity
H9X60_RS19660	COG0039	L-malate dehydrogenase activity
H9X60_RS19665	COG1438	arginine binding
H9X60_RS19675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9X60_RS19680	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9X60_RS19690	COG2105	PFAM AIG2 family protein
H9X60_RS19700	COG0729	surface antigen
H9X60_RS19705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9X60_RS19710	COG1253	flavin adenine dinucleotide binding
H9X60_RS19720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9X60_RS19725	COG0642	Histidine kinase
H9X60_RS19735	COG3111	PFAM Bacterial OB fold (BOF) protein
H9X60_RS19740	COG0494	nUDIX hydrolase
H9X60_RS19750	COG0579	oxidoreductase
H9X60_RS19760	COG0545	Peptidyl-prolyl cis-trans isomerase
H9X60_RS19765	COG3061	Opacity-associated protein A
H9X60_RS19775	COG0359	binds to the 23S rRNA
H9X60_RS19780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9X60_RS19785	COG2965	DNA replication, synthesis of RNA primer
H9X60_RS19790	COG0360	Binds together with S18 to 16S ribosomal RNA
H9X60_RS19795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9X60_RS19800	COG0557	exoribonuclease II activity
H9X60_RS19805	COG1959	2 iron, 2 sulfur cluster binding
H9X60_RS19810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9X60_RS19815	COG0330	HflC and HflK could
H9X60_RS19820	COG0330	HflC and HflK could
H9X60_RS19825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9X60_RS19830	COG1923	regulation of RNA biosynthetic process
H9X60_RS19835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9X60_RS19840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9X60_RS19845	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9X60_RS19850	COG0802	atpase or kinase
H9X60_RS19855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9X60_RS19880	COG1162	GTPase activity
H9X60_RS19885	COG0688	phosphatidylethanolamine metabolic process
H9X60_RS19890	COG1511	domain protein
H9X60_RS19890	COG3264	Mechanosensitive ion channel
H9X60_RS19905	COG0561	phosphatase activity
H9X60_RS19910	COG2267	carboxylic ester hydrolase activity
H9X60_RS19925	COG2050	protein possibly involved in aromatic compounds catabolism
H9X60_RS19935	COG0531	amino acid
H9X60_RS19950	COG1690	Belongs to the RtcB family
H9X60_RS19955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9X60_RS19975	COG0210	DNA helicase
H9X60_RS19980	COG1011	Hydrolase
H9X60_RS19995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9X60_RS20000	COG5567	small periplasmic lipoprotein
H9X60_RS20005	COG1965	Belongs to the frataxin family
H9X60_RS20025	COG2959	enzyme of heme biosynthesis
H9X60_RS20030	COG3071	HemY protein
H9X60_RS20065	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H9X60_RS20075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9X60_RS20080	COG2244	polysaccharide biosynthetic process
H9X60_RS20085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9X60_RS20095	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H9X60_RS20100	COG1088	dTDP-glucose 4,6-dehydratase activity
H9X60_RS20105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9X60_RS20110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9X60_RS20115	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H9X60_RS20120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9X60_RS20125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9X60_RS20130	COG3118	belongs to the thioredoxin family
H9X60_RS20135	COG0513	Belongs to the DEAD box helicase family
H9X60_RS20140	COG0248	Ppx GppA phosphatase
H9X60_RS20145	COG0210	DNA helicase
H9X60_RS20150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9X60_RS20165	COG0129	dihydroxy-acid dehydratase activity
H9X60_RS20175	COG3978	acetolactate synthase activity
H9X60_RS20190	COG0606	chelatase, subunit chli
H9X60_RS20195	COG3085	chromosome segregation
H9X60_RS20200	COG0583	DNA-binding transcription factor activity
H9X60_RS20235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9X60_RS20245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9X60_RS20250	COG0009	L-threonylcarbamoyladenylate synthase
H9X60_RS20255	COG0551	DNA topoisomerase type I activity
H9X60_RS20260	COG0758	DNA mediated transformation
H9X60_RS20270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9X60_RS20280	COG0569	domain protein
H9X60_RS20290	COG3036	rescue of stalled ribosome
H9X60_RS20295	COG0789	Transcriptional regulator
H9X60_RS20310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9X60_RS20320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9X60_RS20325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9X60_RS20330	COG0201	protein transport
H9X60_RS20335	COG0200	Binds to the 23S rRNA
H9X60_RS20340	COG1841	ribosomal large subunit assembly
H9X60_RS20345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9X60_RS20350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9X60_RS20355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9X60_RS20360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9X60_RS20365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9X60_RS20370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9X60_RS20375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9X60_RS20380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9X60_RS20385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9X60_RS20395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9X60_RS20405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9X60_RS20415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9X60_RS20420	COG0089	rRNA binding
H9X60_RS20425	COG0088	Forms part of the polypeptide exit tunnel
H9X60_RS20430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9X60_RS20435	COG0051	transcription antitermination factor activity, RNA binding
H9X60_RS20440	COG2193	ferroxidase activity
H9X60_RS20475	COG1072	(Pantothenic acid kinase))
H9X60_RS20485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9X60_RS20520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9X60_RS20530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9X60_RS20545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9X60_RS20565	COG0165	Argininosuccinate lyase
H9X60_RS20570	COG0137	argininosuccinate synthase activity
H9X60_RS20575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9X60_RS20580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9X60_RS20585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9X60_RS20590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9X60_RS20595	COG0076	glutamate decarboxylase activity
H9X60_RS20600	COG0531	amino acid
H9X60_RS20605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9X60_RS20610	COG0527	aspartate kinase activity
H9X60_RS20610	COG0460	homoserine dehydrogenase
H9X60_RS20615	COG0626	cystathionine gamma-synthase activity
H9X60_RS20630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9X60_RS20635	COG1609	Transcriptional regulator
H9X60_RS20640	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9X60_RS20645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9X60_RS20650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9X60_RS20655	COG1575	Belongs to the MenA family. Type 1 subfamily
H9X60_RS20660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9X60_RS20665	COG3074	FtsZ-dependent cytokinesis
H9X60_RS20675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9X60_RS20685	COG2814	Major facilitator Superfamily
H9X60_RS20695	COG3152	Membrane
H9X60_RS20705	COG0149	triose-phosphate isomerase activity
H9X60_RS20715	COG1472	Belongs to the glycosyl hydrolase 3 family
H9X60_RS20735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9X60_RS20740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9X60_RS20745	COG1116	anion transmembrane transporter activity
H9X60_RS20750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9X60_RS20755	COG0431	NADPH-dependent FMN reductase
H9X60_RS20760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9X60_RS20765	COG1879	ABC-type sugar transport system periplasmic component
H9X60_RS20770	COG1129	ABC transporter
H9X60_RS20775	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9X60_RS20780	COG1957	nucleoside hydrolase
H9X60_RS20785	COG1064	alcohol dehydrogenase
H9X60_RS20795	COG2207	Transcriptional regulator
H9X60_RS20800	COG0205	6-phosphofructokinase activity
H9X60_RS20805	COG4589	Belongs to the CDS family
H9X60_RS20815	COG0501	Belongs to the peptidase M48B family
H9X60_RS20825	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9X60_RS20830	COG3657	addiction module killer protein
H9X60_RS20835	COG3678	ATP-independent chaperone mediated protein folding
H9X60_RS20840	COG0745	RESPONSE REGULATOR receiver
H9X60_RS20845	COG2205	protein histidine kinase activity
H9X60_RS20855	COG1088	dTDP-glucose 4,6-dehydratase activity
H9X60_RS20860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H9X60_RS20875	COG0110	maltose O-acetyltransferase activity
H9X60_RS20895	COG0463	Glycosyl transferase, family 2
H9X60_RS20920	COG1596	polysaccharide export
H9X60_RS20925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9X60_RS20930	COG0489	protein tyrosine kinase activity
H9X60_RS20930	COG3206	protein involved in exopolysaccharide biosynthesis
H9X60_RS20935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9X60_RS20940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9X60_RS20945	COG2337	Toxic component of a toxin-antitoxin (TA) module
H9X60_RS20955	COG1045	serine acetyltransferase
H9X60_RS20960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9X60_RS20970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9X60_RS20975	COG4942	peptidase
H9X60_RS20980	COG2861	carbohydrate metabolic process
H9X60_RS20985	COG1063	alcohol dehydrogenase
H9X60_RS20990	COG0156	8-amino-7-oxononanoate synthase activity
H9X60_RS20995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9X60_RS21015	COG1519	Transferase
H9X60_RS21020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9X60_RS21025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9X60_RS21050	COG0515	serine threonine protein kinase
H9X60_RS21055	COG0438	transferase activity, transferring glycosyl groups
H9X60_RS21060	COG0859	PFAM glycosyl transferase family 9
H9X60_RS21070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9X60_RS21075	COG2003	Belongs to the UPF0758 family
H9X60_RS21080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9X60_RS21085	COG0756	dUTP diphosphatase activity
H9X60_RS21090	COG1309	transcriptional regulator
H9X60_RS21095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9X60_RS21100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9X60_RS21105	COG1561	YicC-like family, N-terminal region
H9X60_RS21110	COG2271	Major facilitator Superfamily
H9X60_RS21115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9X60_RS21115	COG0473	3-isopropylmalate dehydrogenase activity
H9X60_RS21120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9X60_RS21130	COG2211	Major facilitator Superfamily
H9X60_RS21145	COG1846	Transcriptional regulator
H9X60_RS21145	COG1940	carbohydrate kinase activity
H9X60_RS21155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9X60_RS21170	COG1368	sulfuric ester hydrolase activity
H9X60_RS21175	COG3276	selenocysteine insertion sequence binding
H9X60_RS21180	COG1921	L-seryl-tRNASec selenium transferase activity
H9X60_RS21185	COG3058	Necessary for formate dehydrogenase activity
H9X60_RS21205	COG1312	Catalyzes the dehydration of D-mannonate
H9X60_RS21210	COG2186	Transcriptional regulator
H9X60_RS21215	COG4948	Mandelate Racemase Muconate Lactonizing
H9X60_RS21220	COG1063	alcohol dehydrogenase
H9X60_RS21225	COG0477	Major facilitator Superfamily
H9X60_RS21230	COG0246	Mannitol dehydrogenase
H9X60_RS21245	COG0679	Auxin Efflux Carrier
H9X60_RS21250	COG0028	Belongs to the TPP enzyme family
H9X60_RS21260	COG2864	formate dehydrogenase
H9X60_RS21265	COG0437	4 iron, 4 sulfur cluster binding
H9X60_RS21275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9X60_RS21280	COG3550	peptidyl-serine autophosphorylation
H9X60_RS21290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9X60_RS21295	COG0706	membrane insertase activity
H9X60_RS21300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9X60_RS21305	COG0594	ribonuclease P activity
H9X60_RS21310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9X60_RS21320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9X60_RS21325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9X60_RS21335	COG0629	single-stranded DNA binding
H9X60_RS21350	COG3157	Type VI secretion system effector, Hcp
H9X60_RS21370	COG1192	Involved in chromosome partitioning
H9X60_RS21375	COG2336	PFAM SpoVT AbrB
H9X60_RS21380	COG2337	Toxic component of a toxin-antitoxin (TA) module
H9X60_RS21445	COG0488	(ABC) transporter
H9X60_RS21450	COG3173	Aminoglycoside phosphotransferase
H9X60_RS21665	COG0673	inositol 2-dehydrogenase activity
H9X60_RS21670	COG1324	tolerance protein
H9X60_RS21895	COG0681	Belongs to the peptidase S26 family
H9X60_RS22110	COG0739	heme binding
H9X60_RS22110	COG1196	nuclear chromosome segregation
H9X60_RS22110	COG0741	lytic transglycosylase activity
H9X60_RS22155	COG0488	(ABC) transporter
H9X60_RS22160	COG0488	(ABC) transporter
H9X60_RS22210	COG0484	heat shock protein binding
H9X60_RS22250	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis