locus-tag	class	description
D9T18_RS00010	COG0592	DNA-directed DNA polymerase activity
D9T18_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9T18_RS00020	COG0187	DNA topoisomerase II activity
D9T18_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
D9T18_RS00030	COG0751	glycine-tRNA ligase activity
D9T18_RS00050	COG0425	Belongs to the sulfur carrier protein TusA family
D9T18_RS00055	COG0183	Belongs to the thiolase family
D9T18_RS00060	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9T18_RS00060	COG1024	Enoyl-CoA hydratase
D9T18_RS00065	COG0741	lytic transglycosylase activity
D9T18_RS00070	COG0006	proline dipeptidase activity
D9T18_RS00075	COG1739	Uncharacterized protein family UPF0029
D9T18_RS00080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9T18_RS00105	COG0569	domain protein
D9T18_RS00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9T18_RS00110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9T18_RS00115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9T18_RS00120	COG0242	peptide deformylase activity
D9T18_RS00130	COG0758	DNA mediated transformation
D9T18_RS00135	COG2922	Belongs to the Smg family
D9T18_RS00140	COG0551	DNA topoisomerase type I activity
D9T18_RS00145	COG0009	L-threonylcarbamoyladenylate synthase
D9T18_RS00150	COG0408	coproporphyrinogen oxidase activity
D9T18_RS00155	COG2346	COG2346, Truncated hemoglobins
D9T18_RS00160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9T18_RS00170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9T18_RS00225	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9T18_RS00290	COG2205	protein histidine kinase activity
D9T18_RS00290	COG3437	response regulator, receiver
D9T18_RS00290	COG3850	Histidine kinase
D9T18_RS00290	COG4999	Histidine kinase
D9T18_RS00310	COG1597	lipid kinase activity
D9T18_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9T18_RS00335	COG0386	Belongs to the glutathione peroxidase family
D9T18_RS00345	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D9T18_RS00375	COG1404	Belongs to the peptidase S8 family
D9T18_RS00380	COG1770	oligopeptidase
D9T18_RS00385	COG5002	protein histidine kinase activity
D9T18_RS00390	COG0745	RESPONSE REGULATOR receiver
D9T18_RS00410	COG1238	metal cluster binding
D9T18_RS00415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9T18_RS00420	COG0302	gtp cyclohydrolase
D9T18_RS00430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9T18_RS00435	COG3132	Protein of unknown function, DUF480
D9T18_RS00440	COG0784	Response regulator, receiver
D9T18_RS00440	COG5002	protein histidine kinase activity
D9T18_RS00440	COG2205	protein histidine kinase activity
D9T18_RS00445	COG1944	ATP diphosphatase activity
D9T18_RS00455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T18_RS00460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9T18_RS00460	COG3153	acetyltransferase
D9T18_RS00490	COG1187	pseudouridine synthase activity
D9T18_RS00520	COG1011	Hydrolase
D9T18_RS00525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D9T18_RS00535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9T18_RS00540	COG0019	diaminopimelate decarboxylase activity
D9T18_RS00550	COG1965	Belongs to the frataxin family
D9T18_RS00555	COG0400	carboxylic ester hydrolase activity
D9T18_RS00565	COG0181	hydroxymethylbilane synthase activity
D9T18_RS00570	COG2959	enzyme of heme biosynthesis
D9T18_RS00585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D9T18_RS00600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D9T18_RS00610	COG2354	Protein conserved in bacteria
D9T18_RS00615	COG1506	peptidase
D9T18_RS00630	COG4774	siderophore transport
D9T18_RS00635	COG0513	Belongs to the DEAD box helicase family
D9T18_RS00645	COG2205	protein histidine kinase activity
D9T18_RS00645	COG0784	Response regulator, receiver
D9T18_RS00645	COG2198	Histidine kinase
D9T18_RS00655	COG3118	belongs to the thioredoxin family
D9T18_RS00665	COG0248	Ppx GppA phosphatase
D9T18_RS00700	COG1444	tRNA N-acetyltransferase activity
D9T18_RS00705	COG0210	DNA helicase
D9T18_RS00715	COG3112	Uncharacterised protein family (UPF0231)
D9T18_RS00730	COG1011	Hydrolase
D9T18_RS00735	COG0494	nUDIX hydrolase
D9T18_RS00740	COG1218	3'(2'),5'-bisphosphate nucleotidase
D9T18_RS00770	COG0606	chelatase, subunit chli
D9T18_RS00785	COG1253	flavin adenine dinucleotide binding
D9T18_RS00800	COG2031	fatty acid transporter
D9T18_RS00825	COG1946	Acyl-CoA thioesterase
D9T18_RS00830	COG2937	Belongs to the GPAT DAPAT family
D9T18_RS00835	COG0051	transcription antitermination factor activity, RNA binding
D9T18_RS00840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9T18_RS00845	COG0088	Forms part of the polypeptide exit tunnel
D9T18_RS00850	COG0089	rRNA binding
D9T18_RS00855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9T18_RS00860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9T18_RS00865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9T18_RS00870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9T18_RS00875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9T18_RS00880	COG0255	Belongs to the universal ribosomal protein uL29 family
D9T18_RS00885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9T18_RS00905	COG2356	endonuclease I
D9T18_RS00915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9T18_RS00935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9T18_RS00965	COG2204	response regulator
D9T18_RS00970	COG3852	Histidine kinase
D9T18_RS00980	COG0174	glutamine synthetase
D9T18_RS00985	COG1217	gtp-binding protein TYPA
D9T18_RS01005	COG1295	ribonuclease BN
D9T18_RS01010	COG1490	D-aminoacyl-tRNA deacylase activity
D9T18_RS01020	COG0456	acetyltransferase
D9T18_RS01035	COG0019	diaminopimelate decarboxylase activity
D9T18_RS01045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9T18_RS01055	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D9T18_RS01065	COG1049	propionate catabolic process, 2-methylcitrate cycle
D9T18_RS01075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9T18_RS01110	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9T18_RS01120	COG2186	Transcriptional regulator
D9T18_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS01130	COG3734	2-keto-3-deoxy-galactonokinase
D9T18_RS01135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9T18_RS01150	COG0673	inositol 2-dehydrogenase activity
D9T18_RS01155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D9T18_RS01165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9T18_RS01170	COG0300	oxidoreductase activity
D9T18_RS01180	COG0604	alcohol dehydrogenase
D9T18_RS01180	COG3321	synthase
D9T18_RS01185	COG3300	MHYT domain
D9T18_RS01185	COG5001	Diguanylate cyclase
D9T18_RS01200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9T18_RS01210	COG1012	belongs to the aldehyde dehydrogenase family
D9T18_RS01220	COG1765	OsmC-like protein
D9T18_RS01225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9T18_RS01230	COG0814	amino acid
D9T18_RS01235	COG1218	3'(2'),5'-bisphosphate nucleotidase
D9T18_RS01240	COG0529	Catalyzes the synthesis of activated sulfate
D9T18_RS01245	COG0471	metal ion transport
D9T18_RS01245	COG3273	potassium ion transport
D9T18_RS01250	COG2895	sulfate adenylyltransferase (ATP) activity
D9T18_RS01255	COG0175	sulfate reduction
D9T18_RS01260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9T18_RS01260	COG1648	precorrin-2 dehydrogenase activity
D9T18_RS01265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9T18_RS01280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9T18_RS01285	COG0250	Participates in transcription elongation, termination and antitermination
D9T18_RS01290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D9T18_RS01295	COG0081	regulation of translation
D9T18_RS01300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9T18_RS01305	COG0222	ribosome binding
D9T18_RS01310	COG0085	RNA polymerase activity
D9T18_RS01315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9T18_RS01320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D9T18_RS01325	COG0049	tRNA binding
D9T18_RS01330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9T18_RS01335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9T18_RS01355	COG2205	protein histidine kinase activity
D9T18_RS01355	COG0784	Response regulator, receiver
D9T18_RS01360	COG1119	ATPase activity
D9T18_RS01380	COG0129	dihydroxy-acid dehydratase activity
D9T18_RS01400	COG0288	reversible hydration of carbon dioxide
D9T18_RS01420	COG5001	Diguanylate cyclase
D9T18_RS01430	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D9T18_RS01435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9T18_RS01435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9T18_RS01455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9T18_RS01485	COG0312	modulator of DNA gyrase
D9T18_RS01495	COG3590	peptidase
D9T18_RS01505	COG0494	nUDIX hydrolase
D9T18_RS01510	COG0653	protein targeting
D9T18_RS01520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9T18_RS01530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D9T18_RS01540	COG1228	amidohydrolase
D9T18_RS01555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9T18_RS01560	COG0671	phosphoesterase, PA-phosphatase related
D9T18_RS01580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9T18_RS01585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9T18_RS01595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9T18_RS01600	COG0254	rRNA binding
D9T18_RS01605	COG0281	malic enzyme
D9T18_RS01610	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D9T18_RS01615	COG0626	cystathionine gamma-synthase activity
D9T18_RS01620	COG0527	aspartate kinase activity
D9T18_RS01620	COG0460	homoserine dehydrogenase
D9T18_RS01625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9T18_RS01655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D9T18_RS01660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9T18_RS01670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D9T18_RS01685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9T18_RS01695	COG0180	Tryptophanyl-tRNA synthetase
D9T18_RS01700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9T18_RS01705	COG2814	Major facilitator Superfamily
D9T18_RS01710	COG0629	single-stranded DNA binding
D9T18_RS01730	COG2814	Major facilitator Superfamily
D9T18_RS01735	COG0583	DNA-binding transcription factor activity
D9T18_RS01740	COG5002	protein histidine kinase activity
D9T18_RS01740	COG2205	protein histidine kinase activity
D9T18_RS01740	COG0784	Response regulator, receiver
D9T18_RS01745	COG0431	NADPH-dependent FMN reductase
D9T18_RS01750	COG0798	PFAM Bile acid sodium symporter
D9T18_RS01765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D9T18_RS01795	COG3409	Peptidoglycan-binding domain 1 protein
D9T18_RS01795	COG3267	Type II secretory pathway component ExeA
D9T18_RS01805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T18_RS01810	COG1459	type II secretion system
D9T18_RS01815	COG2165	general secretion pathway protein
D9T18_RS01820	COG2165	general secretion pathway protein
D9T18_RS01825	COG2165	general secretion pathway protein
D9T18_RS01855	COG1077	Cell shape determining protein MreB Mrl
D9T18_RS01860	COG1792	Involved in formation and maintenance of cell shape
D9T18_RS01865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D9T18_RS01870	COG0424	maF-like protein
D9T18_RS01875	COG1530	ribonuclease E activity
D9T18_RS01880	COG3164	Protein of unknown function
D9T18_RS01885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9T18_RS01890	COG0312	modulator of DNA gyrase
D9T18_RS01895	COG0668	transmembrane transport
D9T18_RS01935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9T18_RS01940	COG0339	signal peptide processing
D9T18_RS01950	COG0742	ribosomal rna small subunit methyltransferase
D9T18_RS01955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D9T18_RS01965	COG1104	cysteine desulfurase activity
D9T18_RS01970	COG0822	iron-sulfur transferase activity
D9T18_RS01980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9T18_RS01985	COG0443	Heat shock 70 kDa protein
D9T18_RS02005	COG0668	transmembrane transport
D9T18_RS02010	COG3137	Salt-induced outer membrane protein
D9T18_RS02050	COG1215	transferase activity, transferring glycosyl groups
D9T18_RS02055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9T18_RS02070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9T18_RS02075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9T18_RS02260	COG0438	transferase activity, transferring glycosyl groups
D9T18_RS02260	COG1216	Glycosyl transferase, family 2
D9T18_RS02275	COG0175	sulfate reduction
D9T18_RS02280	COG2895	sulfate adenylyltransferase (ATP) activity
D9T18_RS02285	COG0471	metal ion transport
D9T18_RS02285	COG3273	potassium ion transport
D9T18_RS02290	COG0529	Catalyzes the synthesis of activated sulfate
D9T18_RS02300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9T18_RS02315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9T18_RS02320	COG1842	Phage shock protein A
D9T18_RS02360	COG5001	Diguanylate cyclase
D9T18_RS02360	COG3300	MHYT domain
D9T18_RS02365	COG1032	radical SAM domain protein
D9T18_RS02370	COG0840	transmembrane signaling receptor activity
D9T18_RS02375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9T18_RS02380	COG2967	ApaG domain
D9T18_RS02385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9T18_RS02390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D9T18_RS02395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9T18_RS02400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D9T18_RS02405	COG3178	'Phosphotransferase
D9T18_RS02410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9T18_RS02415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9T18_RS02435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9T18_RS02440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D9T18_RS02460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9T18_RS02470	COG3313	Fe-S protein
D9T18_RS02495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9T18_RS02500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9T18_RS02500	COG1042	CoA-binding domain protein
D9T18_RS02500	COG0045	succinate-CoA ligase (ADP-forming) activity
D9T18_RS02520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9T18_RS02525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9T18_RS02535	COG0762	integral membrane protein
D9T18_RS02540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9T18_RS02545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D9T18_RS02560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9T18_RS02565	COG1678	Uncharacterized ACR, COG1678
D9T18_RS02575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9T18_RS02590	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D9T18_RS02600	COG1560	Kdo2-lipid A biosynthetic process
D9T18_RS02605	COG1538	Outer membrane efflux protein
D9T18_RS02610	COG0494	nUDIX hydrolase
D9T18_RS02615	COG3151	Protein conserved in bacteria
D9T18_RS02625	COG3150	esterase
D9T18_RS02645	COG0204	Acyl-transferase
D9T18_RS02650	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D9T18_RS02665	COG4067	protein conserved in archaea
D9T18_RS02665	COG0189	ligase activity
D9T18_RS02670	COG0189	ligase activity
D9T18_RS02695	COG0514	ATP-dependent DNA helicase (RecQ)
D9T18_RS02700	COG2050	protein possibly involved in aromatic compounds catabolism
D9T18_RS02705	COG2962	Rard protein
D9T18_RS02715	COG3085	chromosome segregation
D9T18_RS02720	COG0583	DNA-binding transcription factor activity
D9T18_RS02735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9T18_RS02740	COG1492	cobalamin metabolic process
D9T18_RS02745	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D9T18_RS02750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9T18_RS02755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D9T18_RS02770	COG3022	response to hydroperoxide
D9T18_RS02775	COG0668	transmembrane transport
D9T18_RS02785	COG0513	Belongs to the DEAD box helicase family
D9T18_RS02790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D9T18_RS02815	COG0716	FMN binding
D9T18_RS02825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9T18_RS02840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D9T18_RS02875	COG3876	Protein conserved in bacteria
D9T18_RS02880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9T18_RS02885	COG1757	Na H antiporter
D9T18_RS02890	COG3263	regulation of cellular component size
D9T18_RS02920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9T18_RS02940	COG2137	regulation of response to DNA damage stimulus
D9T18_RS02945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9T18_RS02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9T18_RS02975	COG3630	sodium ion export across plasma membrane
D9T18_RS02980	COG5016	pyruvate
D9T18_RS02980	COG0511	ligase activity, forming carbon-carbon bonds
D9T18_RS02990	COG4989	oxidoreductase activity
D9T18_RS03000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9T18_RS03010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9T18_RS03020	COG1469	GTP cyclohydrolase I activity
D9T18_RS03025	COG2198	Histidine kinase
D9T18_RS03025	COG0784	Response regulator, receiver
D9T18_RS03025	COG5002	protein histidine kinase activity
D9T18_RS03030	COG0745	RESPONSE REGULATOR receiver
D9T18_RS03035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T18_RS03035	COG4191	Histidine kinase
D9T18_RS03040	COG2813	Specifically methylates the guanine in position
D9T18_RS03045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9T18_RS03050	COG1194	a g-specific adenine glycosylase
D9T18_RS03055	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D9T18_RS03105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T18_RS03115	COG3079	Belongs to the UPF0149 family
D9T18_RS03120	COG0006	proline dipeptidase activity
D9T18_RS03125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9T18_RS03130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9T18_RS03145	COG0360	Binds together with S18 to 16S ribosomal RNA
D9T18_RS03150	COG2965	DNA replication, synthesis of RNA primer
D9T18_RS03155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9T18_RS03160	COG0359	binds to the 23S rRNA
D9T18_RS03165	COG1595	DNA-templated transcription, initiation
D9T18_RS03180	COG0305	Participates in initiation and elongation during chromosome replication
D9T18_RS03185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9T18_RS03220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9T18_RS03235	COG0525	valine-tRNA ligase activity
D9T18_RS03240	COG2927	DNA polymerase III (CHI subunit)
D9T18_RS03245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9T18_RS03250	COG0795	lipopolysaccharide-transporting ATPase activity
D9T18_RS03255	COG0795	lipopolysaccharide-transporting ATPase activity
D9T18_RS03290	COG4771	TonB-dependent receptor
D9T18_RS03295	COG0583	DNA-binding transcription factor activity
D9T18_RS03305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9T18_RS03310	COG1473	amidohydrolase
D9T18_RS03330	COG0438	transferase activity, transferring glycosyl groups
D9T18_RS03355	COG2807	transmembrane transport
D9T18_RS03360	COG2207	Transcriptional regulator
D9T18_RS03365	COG4206	TonB-dependent receptor
D9T18_RS03420	COG2204	response regulator
D9T18_RS03430	COG4251	negative regulation of phosphorylation
D9T18_RS03435	COG0784	Response regulator, receiver
D9T18_RS03440	COG2205	protein histidine kinase activity
D9T18_RS03440	COG0784	Response regulator, receiver
D9T18_RS03445	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9T18_RS03455	COG0667	Aldo Keto reductase
D9T18_RS03465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9T18_RS03470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9T18_RS03475	COG0840	transmembrane signaling receptor activity
D9T18_RS03500	COG2974	May be involved in recombination
D9T18_RS03505	COG4191	Histidine kinase
D9T18_RS03505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T18_RS03510	COG2201	protein-glutamate methylesterase activity
D9T18_RS03525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D9T18_RS03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9T18_RS03535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9T18_RS03540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9T18_RS03540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9T18_RS03555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9T18_RS03560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9T18_RS03570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9T18_RS03575	COG3706	GGDEF domain
D9T18_RS03580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9T18_RS03585	COG0142	geranyltranstransferase activity
D9T18_RS03590	COG1722	exodeoxyribonuclease VII activity
D9T18_RS03595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9T18_RS03610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9T18_RS03615	COG1473	amidohydrolase
D9T18_RS03620	COG3118	belongs to the thioredoxin family
D9T18_RS03645	COG2066	Belongs to the glutaminase family
D9T18_RS03650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9T18_RS03660	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D9T18_RS03665	COG0047	phosphoribosylformylglycinamidine synthase activity
D9T18_RS03665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9T18_RS03680	COG3784	Protein of unknown function (DUF1318)
D9T18_RS03690	COG1519	Transferase
D9T18_RS03695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D9T18_RS03700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D9T18_RS03700	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D9T18_RS03715	COG0438	transferase activity, transferring glycosyl groups
D9T18_RS03720	COG3642	lipopolysaccharide core region biosynthetic process
D9T18_RS03725	COG0859	PFAM glycosyl transferase family 9
D9T18_RS03730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9T18_RS03735	COG0156	8-amino-7-oxononanoate synthase activity
D9T18_RS03740	COG1063	alcohol dehydrogenase
D9T18_RS03745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9T18_RS03750	COG0705	Rhomboid family
D9T18_RS03755	COG1580	Controls the rotational direction of flagella during chemotaxis
D9T18_RS03760	COG3161	chorismate lyase activity
D9T18_RS03765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D9T18_RS03775	COG0583	DNA-binding transcription factor activity
D9T18_RS03795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9T18_RS03800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9T18_RS03805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9T18_RS03815	COG1968	undecaprenyl-diphosphatase activity
D9T18_RS03830	COG0163	prenyltransferase activity
D9T18_RS03835	COG1131	(ABC) transporter
D9T18_RS03840	COG0842	Transport permease protein
D9T18_RS03855	COG0076	glutamate decarboxylase activity
D9T18_RS03865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9T18_RS03870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9T18_RS03880	COG0137	argininosuccinate synthase activity
D9T18_RS03885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9T18_RS03885	COG0165	Argininosuccinate lyase
D9T18_RS03935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9T18_RS03940	COG1309	transcriptional regulator
D9T18_RS03945	COG0301	tRNA thio-modification
D9T18_RS03945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9T18_RS03950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9T18_RS03960	COG1666	GTP binding
D9T18_RS03975	COG4206	TonB-dependent receptor
D9T18_RS04020	COG3409	Peptidoglycan-binding domain 1 protein
D9T18_RS04020	COG3267	Type II secretory pathway component ExeA
D9T18_RS04035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D9T18_RS04035	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D9T18_RS04035	COG0506	proline dehydrogenase activity
D9T18_RS04045	COG4991	sh3 domain protein
D9T18_RS04050	COG3025	triphosphatase activity
D9T18_RS04060	COG2198	Histidine kinase
D9T18_RS04060	COG0784	Response regulator, receiver
D9T18_RS04060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T18_RS04060	COG2205	protein histidine kinase activity
D9T18_RS04080	COG0004	ammonium transporteR
D9T18_RS04085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9T18_RS04090	COG0840	transmembrane signaling receptor activity
D9T18_RS04095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9T18_RS04100	COG0540	Belongs to the ATCase OTCase family
D9T18_RS04105	COG1981	membrane
D9T18_RS04115	COG0316	Belongs to the HesB IscA family
D9T18_RS04130	COG2211	Major facilitator Superfamily
D9T18_RS04145	COG2813	Specifically methylates the guanine in position
D9T18_RS04155	COG0271	Belongs to the BolA IbaG family
D9T18_RS04160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9T18_RS04165	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D9T18_RS04170	COG1805	sodium ion transport
D9T18_RS04175	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D9T18_RS04180	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D9T18_RS04185	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D9T18_RS04190	COG2871	sodium ion transport
D9T18_RS04195	COG1477	protein flavinylation
D9T18_RS04200	COG2991	Protein conserved in bacteria
D9T18_RS04210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9T18_RS04230	COG0109	protoheme IX farnesyltransferase activity
D9T18_RS04240	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D9T18_RS04255	COG3706	GGDEF domain
D9T18_RS04265	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9T18_RS04275	COG0488	(ABC) transporter
D9T18_RS04280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D9T18_RS04285	COG0646	methionine synthase
D9T18_RS04285	COG1410	methionine synthase
D9T18_RS04290	COG0646	methionine synthase
D9T18_RS04290	COG1410	methionine synthase
D9T18_RS04315	COG3237	CsbD-like
D9T18_RS04320	COG1643	Atp-dependent helicase
D9T18_RS04345	COG4772	TonB-dependent receptor
D9T18_RS04370	COG1064	alcohol dehydrogenase
D9T18_RS04375	COG2814	Major facilitator Superfamily
D9T18_RS04410	COG1764	response to oxidative stress
D9T18_RS04420	COG0415	Belongs to the DNA photolyase family
D9T18_RS04425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9T18_RS04435	COG2205	protein histidine kinase activity
D9T18_RS04440	COG0745	RESPONSE REGULATOR receiver
D9T18_RS04465	COG5001	Diguanylate cyclase
D9T18_RS04470	COG0625	glutathione transferase activity
D9T18_RS04480	COG0693	protein deglycase activity
D9T18_RS04485	COG0583	DNA-binding transcription factor activity
D9T18_RS04505	COG0339	signal peptide processing
D9T18_RS04515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D9T18_RS04515	COG3264	Mechanosensitive ion channel
D9T18_RS04520	COG4771	TonB-dependent receptor
D9T18_RS04535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9T18_RS04545	COG0443	Heat shock 70 kDa protein
D9T18_RS04550	COG1803	Methylglyoxal synthase
D9T18_RS04575	COG0739	heme binding
D9T18_RS04580	COG3141	response to X-ray
D9T18_RS04595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D9T18_RS04600	COG2186	Transcriptional regulator
D9T18_RS04605	COG0450	alkyl hydroperoxide reductase
D9T18_RS04610	COG4206	TonB-dependent receptor
D9T18_RS04615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9T18_RS04620	COG2867	negative regulation of translational initiation
D9T18_RS04625	COG2914	Belongs to the UPF0125 (RnfH) family
D9T18_RS04630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T18_RS04635	COG2827	Endonuclease containing a URI domain
D9T18_RS04645	COG0840	transmembrane signaling receptor activity
D9T18_RS04650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9T18_RS04655	COG0583	DNA-binding transcription factor activity
D9T18_RS04660	COG3706	GGDEF domain
D9T18_RS04675	COG0745	RESPONSE REGULATOR receiver
D9T18_RS04680	COG2205	protein histidine kinase activity
D9T18_RS04695	COG4326	sporulation control protein
D9T18_RS04700	COG2153	protein acetylation
D9T18_RS04705	COG0733	neurotransmitter:sodium symporter activity
D9T18_RS04710	COG2205	protein histidine kinase activity
D9T18_RS04715	COG0745	RESPONSE REGULATOR receiver
D9T18_RS04740	COG1534	Rna-binding protein
D9T18_RS04745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D9T18_RS04750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D9T18_RS04755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9T18_RS04760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9T18_RS04765	COG0149	triose-phosphate isomerase activity
D9T18_RS04770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9T18_RS04780	COG2197	response regulator
D9T18_RS04790	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T18_RS04795	COG0564	pseudouridine synthase activity
D9T18_RS04805	COG0542	response to heat
D9T18_RS04810	COG0840	transmembrane signaling receptor activity
D9T18_RS04815	COG2918	glutathione biosynthetic process
D9T18_RS04825	COG4536	flavin adenine dinucleotide binding
D9T18_RS04830	COG4137	Cytochrome C assembly protein
D9T18_RS04835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9T18_RS04840	COG0228	four-way junction DNA binding
D9T18_RS04845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9T18_RS04850	COG0336	Belongs to the RNA methyltransferase TrmD family
D9T18_RS04855	COG0335	large ribosomal subunit rRNA binding
D9T18_RS04860	COG1605	Chorismate mutase
D9T18_RS04860	COG0287	Prephenate dehydrogenase
D9T18_RS04865	COG1605	Chorismate mutase
D9T18_RS04865	COG0077	Prephenate dehydratase
D9T18_RS04875	COG0023	Translation Initiation Factor
D9T18_RS04895	COG1448	Aminotransferase
D9T18_RS04910	COG1595	DNA-templated transcription, initiation
D9T18_RS04920	COG2304	oxidoreductase activity
D9T18_RS04940	COG0714	Associated with various cellular activities
D9T18_RS04945	COG0183	Belongs to the thiolase family
D9T18_RS04950	COG1024	Enoyl-CoA hydratase
D9T18_RS04950	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9T18_RS04960	COG2315	Protein conserved in bacteria
D9T18_RS04965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9T18_RS04975	COG3300	MHYT domain
D9T18_RS04975	COG5001	Diguanylate cyclase
D9T18_RS04980	COG1025	Belongs to the peptidase M16 family
D9T18_RS04990	COG0251	oxidation-reduction process
D9T18_RS05000	COG2840	Smr protein MutS2
D9T18_RS05005	COG2890	protein-(glutamine-N5) methyltransferase activity
D9T18_RS05010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9T18_RS05025	COG3101	peptidyl-lysine hydroxylation
D9T18_RS05040	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D9T18_RS05065	COG1335	isochorismatase
D9T18_RS05070	COG0784	Response regulator, receiver
D9T18_RS05070	COG5002	protein histidine kinase activity
D9T18_RS05070	COG2205	protein histidine kinase activity
D9T18_RS05090	COG2204	response regulator
D9T18_RS05105	COG3046	protein related to deoxyribodipyrimidine photolyase
D9T18_RS05120	COG0779	Required for maturation of 30S ribosomal subunits
D9T18_RS05125	COG0195	Participates in both transcription termination and antitermination
D9T18_RS05130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9T18_RS05135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9T18_RS05140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9T18_RS05145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D9T18_RS05150	COG1185	polyribonucleotide nucleotidyltransferase activity
D9T18_RS05165	COG2111	Na H antiporter
D9T18_RS05165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9T18_RS05170	COG1006	Multisubunit Na H antiporter MnhC subunit
D9T18_RS05175	COG0651	ATP synthesis coupled electron transport
D9T18_RS05180	COG1863	multisubunit Na H antiporter MnhE subunit
D9T18_RS05185	COG2212	antiporter activity
D9T18_RS05190	COG1320	monovalent cation:proton antiporter activity
D9T18_RS05205	COG2217	Heavy metal translocating P-type atpase
D9T18_RS05270	COG0583	DNA-binding transcription factor activity
D9T18_RS05285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9T18_RS05290	COG0321	lipoyl(octanoyl) transferase activity
D9T18_RS05295	COG2921	Belongs to the UPF0250 family
D9T18_RS05305	COG1686	Belongs to the peptidase S11 family
D9T18_RS05310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9T18_RS05315	COG0772	Belongs to the SEDS family
D9T18_RS05320	COG0768	penicillin binding
D9T18_RS05325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9T18_RS05330	COG0799	negative regulation of ribosome biogenesis
D9T18_RS05335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D9T18_RS05350	COG0495	leucyl-tRNA aminoacylation
D9T18_RS05355	COG2888	peptidyl-tyrosine sulfation
D9T18_RS05360	COG1067	ATP-dependent peptidase activity
D9T18_RS05365	COG0545	Peptidyl-prolyl cis-trans isomerase
D9T18_RS05380	COG0668	transmembrane transport
D9T18_RS05390	COG2391	methyltransferase activity
D9T18_RS05400	COG0477	Major facilitator Superfamily
D9T18_RS05470	COG1404	Belongs to the peptidase S8 family
D9T18_RS05490	COG4771	TonB-dependent receptor
D9T18_RS05495	COG4771	TonB-dependent receptor
D9T18_RS05515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9T18_RS05540	COG1609	Transcriptional regulator
D9T18_RS05545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9T18_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS05580	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9T18_RS05595	COG1199	ATP-dependent helicase activity
D9T18_RS05600	COG0417	DNA replication proofreading
D9T18_RS05635	COG1061	Type III restriction enzyme res subunit
D9T18_RS05645	COG0729	surface antigen
D9T18_RS05660	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9T18_RS05660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9T18_RS05670	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D9T18_RS05700	COG3098	single-species biofilm formation
D9T18_RS05705	COG0564	pseudouridine synthase activity
D9T18_RS05715	COG1388	LysM domain
D9T18_RS05715	COG0741	lytic transglycosylase activity
D9T18_RS05720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T18_RS05725	COG2226	methyltransferase
D9T18_RS05730	COG0328	RNA-DNA hybrid ribonuclease activity
D9T18_RS05735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9T18_RS05800	COG0121	glutamine amidotransferase
D9T18_RS05810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9T18_RS05815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9T18_RS05820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9T18_RS05825	COG2226	methyltransferase
D9T18_RS05840	COG1451	nucleotide metabolic process
D9T18_RS05845	COG1801	Protein of unknown function DUF72
D9T18_RS05850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9T18_RS05890	COG0513	Belongs to the DEAD box helicase family
D9T18_RS05915	COG0626	cystathionine gamma-synthase activity
D9T18_RS05945	COG1960	acyl-CoA dehydrogenase activity
D9T18_RS05960	COG1823	symporter activity
D9T18_RS05965	COG2197	response regulator
D9T18_RS05970	COG0322	excinuclease ABC activity
D9T18_RS06020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9T18_RS06025	COG1115	amino acid carrier protein
D9T18_RS06055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9T18_RS06060	COG0072	phenylalanine-tRNA ligase activity
D9T18_RS06065	COG0776	regulation of translation
D9T18_RS06080	COG2866	Carboxypeptidase
D9T18_RS06085	COG1115	amino acid carrier protein
D9T18_RS06095	COG3139	Protein of unknown function (DUF1315)
D9T18_RS06140	COG0210	DNA helicase
D9T18_RS06205	COG0393	Putative heavy-metal-binding
D9T18_RS06220	COG2755	lipolytic protein G-D-S-L family
D9T18_RS06225	COG4181	ATPase activity
D9T18_RS06230	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D9T18_RS06235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D9T18_RS06240	COG0632	four-way junction helicase activity
D9T18_RS06245	COG2255	four-way junction helicase activity
D9T18_RS06250	COG0811	peptide transport
D9T18_RS06255	COG0848	biopolymer transport protein
D9T18_RS06265	COG0823	Involved in the tonB-independent uptake of proteins
D9T18_RS06270	COG2885	chlorophyll binding
D9T18_RS06275	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D9T18_RS06315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D9T18_RS06350	COG2828	Protein conserved in bacteria
D9T18_RS06400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D9T18_RS06405	COG1074	ATP-dependent DNA helicase activity
D9T18_RS06410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9T18_RS06425	COG0037	tRNA processing
D9T18_RS06430	COG0589	response to stress
D9T18_RS06435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9T18_RS06450	COG2217	Heavy metal translocating P-type atpase
D9T18_RS06460	COG2010	Cytochrome c
D9T18_RS06475	COG3278	Belongs to the heme-copper respiratory oxidase family
D9T18_RS06505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9T18_RS06510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9T18_RS06515	COG2957	Belongs to the agmatine deiminase family
D9T18_RS06530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9T18_RS06535	COG0583	DNA-binding transcription factor activity
D9T18_RS06570	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D9T18_RS06580	COG3083	sulfuric ester hydrolase activity
D9T18_RS06585	COG3082	Protein of unknown function (DUF1414)
D9T18_RS06590	COG3081	Nucleoid-associated protein
D9T18_RS06595	COG1530	ribonuclease E activity
D9T18_RS06605	COG0546	phosphoglycolate phosphatase activity
D9T18_RS06610	COG0424	maF-like protein
D9T18_RS06615	COG1399	metal-binding, possibly nucleic acid-binding protein
D9T18_RS06620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9T18_RS06625	COG0416	fatty acid biosynthetic process
D9T18_RS06630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9T18_RS06640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9T18_RS06645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9T18_RS06650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9T18_RS06655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9T18_RS06660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9T18_RS06665	COG0470	DNA polymerase III
D9T18_RS06675	COG0084	hydrolase, TatD family'
D9T18_RS06705	COG0527	aspartate kinase activity
D9T18_RS06715	COG0733	neurotransmitter:sodium symporter activity
D9T18_RS06720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9T18_RS06725	COG0386	Belongs to the glutathione peroxidase family
D9T18_RS06730	COG2084	Dehydrogenase
D9T18_RS06755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9T18_RS06765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9T18_RS06770	COG1215	transferase activity, transferring glycosyl groups
D9T18_RS06775	COG1215	transferase activity, transferring glycosyl groups
D9T18_RS06795	COG1215	transferase activity, transferring glycosyl groups
D9T18_RS06820	COG1596	polysaccharide export
D9T18_RS06825	COG3206	protein involved in exopolysaccharide biosynthesis
D9T18_RS06825	COG0489	protein tyrosine kinase activity
D9T18_RS06845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D9T18_RS06845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9T18_RS06855	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D9T18_RS06860	COG0372	Belongs to the citrate synthase family
D9T18_RS06865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9T18_RS06905	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D9T18_RS06910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9T18_RS06915	COG2223	nitrite transmembrane transporter activity
D9T18_RS06920	COG0515	serine threonine protein kinase
D9T18_RS06920	COG2815	serine threonine protein kinase
D9T18_RS06930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9T18_RS06935	COG0243	molybdopterin cofactor binding
D9T18_RS06940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9T18_RS06945	COG0746	molybdenum cofactor guanylyltransferase activity
D9T18_RS06950	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9T18_RS06955	COG0315	cyclic pyranopterin monophosphate synthase activity
D9T18_RS06960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9T18_RS06965	COG0314	molybdopterin synthase activity
D9T18_RS06975	COG2258	MOSC domain
D9T18_RS06980	COG0800	Aldolase
D9T18_RS06985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9T18_RS06985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9T18_RS06990	COG0489	protein tyrosine kinase activity
D9T18_RS06995	COG0717	Belongs to the dCTP deaminase family
D9T18_RS07020	COG0436	Aminotransferase
D9T18_RS07030	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D9T18_RS07050	COG1876	peptidase activity
D9T18_RS07055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9T18_RS07060	COG1393	Belongs to the ArsC family
D9T18_RS07075	COG0857	belongs to the CobB CobQ family
D9T18_RS07075	COG0280	phosphate acetyltransferase
D9T18_RS07080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9T18_RS07085	COG3092	negative regulation of chromosome organization
D9T18_RS07090	COG2226	methyltransferase
D9T18_RS07115	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9T18_RS07120	COG1187	pseudouridine synthase activity
D9T18_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS07130	COG2267	carboxylic ester hydrolase activity
D9T18_RS07135	COG0616	signal peptide processing
D9T18_RS07140	COG1301	dicarboxylic acid transport
D9T18_RS07160	COG2862	Uncharacterized protein family, UPF0114
D9T18_RS07165	COG0366	Alpha amylase catalytic
D9T18_RS07180	COG0366	Alpha amylase catalytic
D9T18_RS07200	COG1609	Transcriptional regulator
D9T18_RS07205	COG0837	glucose binding
D9T18_RS07210	COG1609	Transcriptional regulator
D9T18_RS07225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9T18_RS07235	COG0217	transcriptional regulatory protein
D9T18_RS07240	COG5265	(ABC) transporter
D9T18_RS07250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9T18_RS07255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9T18_RS07265	COG1943	Transposase
D9T18_RS07270	COG2824	Alkylphosphonate utilization operon protein PhnA
D9T18_RS07275	COG0189	ligase activity
D9T18_RS07280	COG0456	acetyltransferase
D9T18_RS07280	COG1214	PFAM Peptidase M22, glycoprotease
D9T18_RS07285	COG1285	pathogenesis
D9T18_RS07315	COG1285	pathogenesis
D9T18_RS07320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9T18_RS07340	COG0583	DNA-binding transcription factor activity
D9T18_RS07345	COG4591	ABC-type transport system involved in lipoprotein release permease component
D9T18_RS07350	COG1136	(ABC) transporter
D9T18_RS07355	COG4591	ABC-type transport system involved in lipoprotein release permease component
D9T18_RS07365	COG0318	PFAM AMP-dependent synthetase and ligase
D9T18_RS07380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9T18_RS07385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9T18_RS07390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9T18_RS07400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9T18_RS07405	COG1522	sequence-specific DNA binding
D9T18_RS07410	COG0659	secondary active sulfate transmembrane transporter activity
D9T18_RS07415	COG2972	Histidine kinase
D9T18_RS07420	COG3279	Response regulator of the LytR AlgR family
D9T18_RS07425	COG0469	pyruvate kinase activity
D9T18_RS07430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9T18_RS07435	COG0252	asparaginase activity
D9T18_RS07440	COG0616	signal peptide processing
D9T18_RS07445	COG1902	pentaerythritol trinitrate reductase activity
D9T18_RS07445	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T18_RS07455	COG0778	Nitroreductase
D9T18_RS07475	COG0545	Peptidyl-prolyl cis-trans isomerase
D9T18_RS07500	COG3738	Protein conserved in bacteria
D9T18_RS07515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9T18_RS07525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9T18_RS07535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D9T18_RS07540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9T18_RS07545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D9T18_RS07550	COG0539	negative regulation of cytoplasmic translation
D9T18_RS07555	COG0776	regulation of translation
D9T18_RS07565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D9T18_RS07570	COG0284	orotidine-5'-phosphate decarboxylase activity
D9T18_RS07590	COG1054	Belongs to the UPF0176 family
D9T18_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS07600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T18_RS07610	COG2176	DNA-directed DNA polymerase activity
D9T18_RS07615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9T18_RS07620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9T18_RS07635	COG0367	asparagine synthase
D9T18_RS07645	COG1984	allophanate hydrolase subunit 2
D9T18_RS07650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9T18_RS07655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T18_RS07655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T18_RS07665	COG0583	DNA-binding transcription factor activity
D9T18_RS07675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9T18_RS07685	COG4770	biotin carboxylase activity
D9T18_RS07695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9T18_RS07700	COG1960	acyl-CoA dehydrogenase activity
D9T18_RS07710	COG0183	Belongs to the thiolase family
D9T18_RS07725	COG1024	Enoyl-CoA hydratase
D9T18_RS07730	COG1024	Enoyl-CoA hydratase
D9T18_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS07820	COG1914	H( )-stimulated, divalent metal cation uptake system
D9T18_RS07830	COG0431	NADPH-dependent FMN reductase
D9T18_RS07860	COG4628	conserved protein (DUF2132)
D9T18_RS07865	COG0604	alcohol dehydrogenase
D9T18_RS07870	COG1309	transcriptional regulator
D9T18_RS07875	COG3130	regulation of translation
D9T18_RS07880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9T18_RS07890	COG4942	peptidase
D9T18_RS07895	COG1607	acyl-coa hydrolase
D9T18_RS07900	COG2056	Na+-H+ antiporter family
D9T18_RS07915	COG0714	Associated with various cellular activities
D9T18_RS07920	COG2201	protein-glutamate methylesterase activity
D9T18_RS07970	COG0745	RESPONSE REGULATOR receiver
D9T18_RS08040	COG0281	malic enzyme
D9T18_RS08045	COG0405	Gamma-glutamyltransferase
D9T18_RS08065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D9T18_RS08070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D9T18_RS08075	COG0488	(ABC) transporter
D9T18_RS08115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T18_RS08145	COG1131	(ABC) transporter
D9T18_RS08190	COG2860	membrane
D9T18_RS08205	COG2197	response regulator
D9T18_RS08225	COG0501	Belongs to the peptidase M48B family
D9T18_RS08235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D9T18_RS08240	COG2226	methyltransferase
D9T18_RS08250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9T18_RS08255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9T18_RS08270	COG1178	ABC-type Fe3 transport system permease component
D9T18_RS08275	COG3842	ATPase activity
D9T18_RS08285	COG0110	maltose O-acetyltransferase activity
D9T18_RS08295	COG0017	Asparaginyl-tRNA synthetase
D9T18_RS08330	COG1720	tRNA m6t6A37 methyltransferase activity
D9T18_RS08335	COG0442	prolyl-tRNA aminoacylation
D9T18_RS08350	COG1668	transmembrane transport
D9T18_RS08355	COG4555	ABC transporter
D9T18_RS08375	COG3152	Membrane
D9T18_RS08380	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9T18_RS08385	COG0022	dehydrogenase e1 component
D9T18_RS08395	COG2988	succinylglutamate desuccinylase activity
D9T18_RS08400	COG0033	Phosphoglucomutase
D9T18_RS08405	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D9T18_RS08430	COG0735	belongs to the Fur family
D9T18_RS08435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9T18_RS08445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D9T18_RS08450	COG0045	succinate-CoA ligase (ADP-forming) activity
D9T18_RS08455	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9T18_RS08460	COG0567	Dehydrogenase, E1 component
D9T18_RS08470	COG1053	succinate dehydrogenase
D9T18_RS08475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D9T18_RS08495	COG2166	iron-sulfur cluster assembly
D9T18_RS08500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D9T18_RS08505	COG0564	pseudouridine synthase activity
D9T18_RS08510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9T18_RS08515	COG2835	tetraacyldisaccharide 4'-kinase activity
D9T18_RS08520	COG1663	tetraacyldisaccharide 4'-kinase activity
D9T18_RS08525	COG1132	(ABC) transporter
D9T18_RS08530	COG0658	competence protein
D9T18_RS08530	COG2333	competence protein COMEC
D9T18_RS08545	COG0488	(ABC) transporter
D9T18_RS08555	COG0116	Belongs to the methyltransferase superfamily
D9T18_RS08555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9T18_RS08565	COG0167	dihydroorotate dehydrogenase activity
D9T18_RS08570	COG2902	Dehydrogenase
D9T18_RS08580	COG4447	cellulose binding
D9T18_RS08600	COG0308	aminopeptidase N
D9T18_RS08605	COG1757	Na H antiporter
D9T18_RS08615	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D9T18_RS08625	COG1956	GAF domain-containing protein
D9T18_RS08650	COG0670	Belongs to the BI1 family
D9T18_RS08660	COG2923	Belongs to the DsrF TusC family
D9T18_RS08670	COG2920	part of a sulfur-relay system
D9T18_RS08685	COG3706	GGDEF domain
D9T18_RS08685	COG2203	Gaf domain
D9T18_RS08685	COG4251	negative regulation of phosphorylation
D9T18_RS08685	COG5001	Diguanylate cyclase
D9T18_RS08690	COG0482	sulfurtransferase activity
D9T18_RS08695	COG2915	High frequency lysogenization protein hflD homolog
D9T18_RS08700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9T18_RS08705	COG2850	peptidyl-arginine hydroxylation
D9T18_RS08720	COG2234	aminopeptidase activity
D9T18_RS08740	COG1132	(ABC) transporter
D9T18_RS08755	COG3977	Valine--pyruvate aminotransferase
D9T18_RS08765	COG2133	pyrroloquinoline quinone binding
D9T18_RS08775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9T18_RS08780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9T18_RS08785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9T18_RS08790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D9T18_RS08795	COG0531	amino acid
D9T18_RS08795	COG1674	ftsk spoiiie
D9T18_RS08805	COG0686	Belongs to the AlaDH PNT family
D9T18_RS08810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9T18_RS08815	COG0492	ferredoxin-NADP+ reductase activity
D9T18_RS08820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D9T18_RS08825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D9T18_RS08830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9T18_RS08835	COG0542	response to heat
D9T18_RS08840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D9T18_RS08845	COG1278	Cold shock
D9T18_RS08860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9T18_RS08880	COG3001	Fructosamine kinase
D9T18_RS08890	COG0307	riboflavin synthase, alpha
D9T18_RS08925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9T18_RS08925	COG2146	nitrite reductase [NAD(P)H] activity
D9T18_RS08930	COG2146	nitrite reductase [NAD(P)H] activity
D9T18_RS08935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9T18_RS08935	COG1648	precorrin-2 dehydrogenase activity
D9T18_RS08965	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D9T18_RS09005	COG2353	YceI-like domain
D9T18_RS09010	COG3038	cytochrome b561
D9T18_RS09020	COG0009	L-threonylcarbamoyladenylate synthase
D9T18_RS09025	COG0613	PHP domain protein
D9T18_RS09030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9T18_RS09035	COG0512	Glutamine amidotransferase of anthranilate synthase
D9T18_RS09040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9T18_RS09045	COG0135	phosphoribosylanthranilate isomerase activity
D9T18_RS09045	COG0134	indole-3-glycerol-phosphate synthase activity
D9T18_RS09060	COG0693	protein deglycase activity
D9T18_RS09065	COG0776	regulation of translation
D9T18_RS09070	COG2917	probably involved in intracellular septation
D9T18_RS09080	COG0733	neurotransmitter:sodium symporter activity
D9T18_RS09085	COG2350	Protein conserved in bacteria
D9T18_RS09155	COG0628	permease
D9T18_RS09185	COG1090	epimerase
D9T18_RS09195	COG1472	Belongs to the glycosyl hydrolase 3 family
D9T18_RS09210	COG2211	Major facilitator Superfamily
D9T18_RS09230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D9T18_RS09255	COG2871	sodium ion transport
D9T18_RS09260	COG2133	pyrroloquinoline quinone binding
D9T18_RS09295	COG3647	Membrane
D9T18_RS09300	COG4221	oxidoreductase activity
D9T18_RS09380	COG2925	Exonuclease
D9T18_RS09385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T18_RS09385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T18_RS09400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS09495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9T18_RS09510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9T18_RS09515	COG0505	Belongs to the CarA family
D9T18_RS09520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9T18_RS09535	COG2267	carboxylic ester hydrolase activity
D9T18_RS09545	COG2814	Major facilitator Superfamily
D9T18_RS09550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9T18_RS09555	COG1420	regulation of RNA biosynthetic process
D9T18_RS09560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9T18_RS09570	COG0497	DNA recombination
D9T18_RS09580	COG2203	Gaf domain
D9T18_RS09580	COG2199	diguanylate cyclase activity
D9T18_RS09585	COG0493	'glutamate synthase
D9T18_RS09590	COG0070	glutamate synthase
D9T18_RS09590	COG0067	glutamate synthase
D9T18_RS09590	COG0069	glutamate synthase activity
D9T18_RS09595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D9T18_RS09600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D9T18_RS09605	COG2766	serine protein kinase
D9T18_RS09610	COG2718	Belongs to the UPF0229 family
D9T18_RS09615	COG2719	SpoVR family
D9T18_RS09625	COG2201	protein-glutamate methylesterase activity
D9T18_RS09630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D9T18_RS09635	COG0563	adenylate kinase activity
D9T18_RS09640	COG0326	Molecular chaperone. Has ATPase activity
D9T18_RS09645	COG0477	Major facilitator Superfamily
D9T18_RS09650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D9T18_RS09655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9T18_RS09665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9T18_RS09670	COG3219	Protein conserved in bacteria
D9T18_RS09675	COG3220	belongs to the UPF0276 family
D9T18_RS09685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9T18_RS09710	COG0848	biopolymer transport protein
D9T18_RS09715	COG0811	peptide transport
D9T18_RS09720	COG0811	peptide transport
D9T18_RS09730	COG1278	Cold shock
D9T18_RS09735	COG0418	dihydroorotase activity
D9T18_RS09740	COG5001	Diguanylate cyclase
D9T18_RS09740	COG4251	negative regulation of phosphorylation
D9T18_RS09740	COG2203	Gaf domain
D9T18_RS09740	COG3706	GGDEF domain
D9T18_RS09745	COG0583	DNA-binding transcription factor activity
D9T18_RS09750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D9T18_RS09755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D9T18_RS09765	COG0823	Involved in the tonB-independent uptake of proteins
D9T18_RS09765	COG1506	peptidase
D9T18_RS09765	COG4946	Tricorn protease homolog
D9T18_RS09770	COG3228	Belongs to the MtfA family
D9T18_RS09805	COG0494	nUDIX hydrolase
D9T18_RS09810	COG1760	l-serine dehydratase
D9T18_RS09825	COG2252	PERMEase
D9T18_RS09840	COG3012	SEC-C Motif Domain Protein
D9T18_RS09875	COG3437	response regulator, receiver
D9T18_RS09885	COG1418	mRNA catabolic process
D9T18_RS09890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9T18_RS09905	COG1643	Atp-dependent helicase
D9T18_RS09920	COG0363	glucosamine-6-phosphate deaminase activity
D9T18_RS09925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9T18_RS09930	COG0166	Belongs to the GPI family
D9T18_RS09935	COG1104	cysteine desulfurase activity
D9T18_RS09955	COG4783	chaperone-mediated protein folding
D9T18_RS09960	COG1393	Belongs to the ArsC family
D9T18_RS09985	COG2854	intermembrane phospholipid transfer
D9T18_RS09995	COG3314	Sporulation integral membrane protein YlbJ
D9T18_RS10005	COG2716	regulation of RNA biosynthetic process
D9T18_RS10040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9T18_RS10045	COG0539	negative regulation of cytoplasmic translation
D9T18_RS10130	COG1061	Type III restriction enzyme res subunit
D9T18_RS10170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9T18_RS10185	COG0602	queuosine metabolic process
D9T18_RS10190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9T18_RS10215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9T18_RS10220	COG0556	nucleotide-excision repair
D9T18_RS10225	COG0534	Mate efflux family protein
D9T18_RS10250	COG2200	EAL domain
D9T18_RS10250	COG2771	luxR family
D9T18_RS10255	COG4657	Part of a membrane complex involved in electron transport
D9T18_RS10260	COG2878	Part of a membrane complex involved in electron transport
D9T18_RS10270	COG4658	electron transport chain
D9T18_RS10275	COG4659	FMN binding
D9T18_RS10280	COG4660	Part of a membrane complex involved in electron transport
D9T18_RS10285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9T18_RS10320	COG3708	Transcriptional regulator
D9T18_RS10320	COG2207	Transcriptional regulator
D9T18_RS10350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D9T18_RS10360	COG0800	Aldolase
D9T18_RS10365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9T18_RS10370	COG2271	Major facilitator Superfamily
D9T18_RS10375	COG1917	Cupin 2, conserved barrel domain protein
D9T18_RS10395	COG0346	lactoylglutathione lyase activity
D9T18_RS10400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9T18_RS10480	COG0745	RESPONSE REGULATOR receiver
D9T18_RS10485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9T18_RS10500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9T18_RS10505	COG3115	cell septum assembly
D9T18_RS10510	COG1196	nuclear chromosome segregation
D9T18_RS10515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9T18_RS10520	COG4269	membrane
D9T18_RS10540	COG1166	arginine decarboxylase activity
D9T18_RS10555	COG1742	UPF0060 membrane protein
D9T18_RS10565	COG0456	acetyltransferase
D9T18_RS10565	COG1214	PFAM Peptidase M22, glycoprotease
D9T18_RS10575	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D9T18_RS10590	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D9T18_RS10595	COG2363	Small membrane protein
D9T18_RS10605	COG0583	DNA-binding transcription factor activity
D9T18_RS10610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D9T18_RS10615	COG5505	Protein of unknown function (DUF819)
D9T18_RS10635	COG2890	protein-(glutamine-N5) methyltransferase activity
D9T18_RS10640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D9T18_RS10645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9T18_RS10650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D9T18_RS10655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D9T18_RS10660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9T18_RS10665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9T18_RS10670	COG0193	aminoacyl-tRNA hydrolase activity
D9T18_RS10675	COG0012	GTP binding
D9T18_RS10730	COG5001	Diguanylate cyclase
D9T18_RS10730	COG3300	MHYT domain
D9T18_RS10735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9T18_RS10740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9T18_RS10745	COG1702	phosphate starvation-inducible protein PhoH
D9T18_RS10750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9T18_RS10755	COG4535	Mg2 and Co2 transporter CorC
D9T18_RS10760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D9T18_RS10775	COG1902	pentaerythritol trinitrate reductase activity
D9T18_RS10780	COG0523	cobalamin synthesis protein
D9T18_RS10790	COG5002	protein histidine kinase activity
D9T18_RS10790	COG0784	Response regulator, receiver
D9T18_RS10830	COG0037	tRNA processing
D9T18_RS10835	COG0825	malonyl-CoA metabolic process
D9T18_RS10840	COG0587	DNA-directed DNA polymerase activity
D9T18_RS10845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9T18_RS10850	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T18_RS10860	COG1294	oxidase, subunit
D9T18_RS10865	COG4890	Cyd operon protein YbgT
D9T18_RS10870	COG4988	ABC transporter
D9T18_RS10875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D9T18_RS10880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9T18_RS10885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T18_RS10890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9T18_RS10895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T18_RS10910	COG0750	zinc metalloprotease
D9T18_RS10915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9T18_RS10920	COG0575	Belongs to the CDS family
D9T18_RS10925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9T18_RS10930	COG0233	cytoplasmic translational termination
D9T18_RS10935	COG0528	UMP kinase activity
D9T18_RS10940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9T18_RS10945	COG0052	Belongs to the universal ribosomal protein uS2 family
D9T18_RS10950	COG0024	Methionine aminopeptidase
D9T18_RS10955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D9T18_RS10960	COG2171	N-acyltransferase activity
D9T18_RS10970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9T18_RS10975	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9T18_RS10985	COG0626	cystathionine gamma-synthase activity
D9T18_RS10990	COG3768	UPF0283 membrane protein
D9T18_RS10995	COG3106	COG3106 Predicted ATPase
D9T18_RS11000	COG1983	PspC domain protein
D9T18_RS11010	COG1842	Phage shock protein A
D9T18_RS11015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9T18_RS11020	COG0747	negative chemotaxis
D9T18_RS11030	COG4171	peptide transport system, permease
D9T18_RS11040	COG4172	Belongs to the ABC transporter superfamily
D9T18_RS11045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9T18_RS11050	COG0776	regulation of translation
D9T18_RS11055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9T18_RS11060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9T18_RS11065	COG0740	serine-type endopeptidase activity
D9T18_RS11070	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9T18_RS11100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9T18_RS11105	COG0215	cysteine-tRNA ligase activity
D9T18_RS11110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D9T18_RS11115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9T18_RS11135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9T18_RS11140	COG1286	toxin biosynthetic process
D9T18_RS11150	COG0285	dihydrofolate synthase activity
D9T18_RS11155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9T18_RS11160	COG0101	tRNA pseudouridine synthase activity
D9T18_RS11180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9T18_RS11185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9T18_RS11190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D9T18_RS11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9T18_RS11200	COG0702	epimerase
D9T18_RS11235	COG0814	amino acid
D9T18_RS11300	COG0745	RESPONSE REGULATOR receiver
D9T18_RS11300	COG2972	Histidine kinase
D9T18_RS11305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D9T18_RS11310	COG1047	Peptidyl-prolyl cis-trans
D9T18_RS11315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9T18_RS11320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9T18_RS11325	COG0196	riboflavin kinase activity
D9T18_RS11330	COG0728	peptidoglycan biosynthetic process
D9T18_RS11335	COG0268	Binds directly to 16S ribosomal RNA
D9T18_RS11340	COG2201	protein-glutamate methylesterase activity
D9T18_RS11360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9T18_RS11380	COG3047	cAMP biosynthetic process
D9T18_RS11400	COG2194	sulfuric ester hydrolase activity
D9T18_RS11420	COG1215	transferase activity, transferring glycosyl groups
D9T18_RS11430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D9T18_RS11455	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9T18_RS11460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9T18_RS11465	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T18_RS11470	COG2853	Lipoprotein
D9T18_RS11490	COG1138	Cytochrome C-type biogenesis protein
D9T18_RS11495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D9T18_RS11500	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9T18_RS11505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9T18_RS11510	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9T18_RS11515	COG4133	protoheme IX ABC transporter activity
D9T18_RS11535	COG0835	chemotaxis
D9T18_RS11545	COG1192	Involved in chromosome partitioning
D9T18_RS11550	COG1360	Flagellar Motor Protein
D9T18_RS11555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9T18_RS11560	COG2201	protein-glutamate methylesterase activity
D9T18_RS11565	COG0643	Histidine kinase
D9T18_RS11565	COG2198	Histidine kinase
D9T18_RS11565	COG0784	Response regulator, receiver
D9T18_RS11570	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D9T18_RS11595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9T18_RS11605	COG1684	flagellar biosynthetic protein fliR
D9T18_RS11610	COG1987	bacterial-type flagellum assembly
D9T18_RS11620	COG3190	flagellar
D9T18_RS11635	COG1580	Controls the rotational direction of flagella during chemotaxis
D9T18_RS11640	COG3144	bacterial-type flagellum assembly
D9T18_RS11660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9T18_RS11665	COG1766	The M ring may be actively involved in energy transduction
D9T18_RS11670	COG1677	Flagellar hook-basal body complex protein FliE
D9T18_RS11685	COG0519	Catalyzes the synthesis of GMP from XMP
D9T18_RS11710	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D9T18_RS11715	COG1334	flagellar protein FlaG
D9T18_RS11720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9T18_RS11740	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9T18_RS11740	COG3951	Flagellar rod assembly protein muramidase FlgJ
D9T18_RS11745	COG1706	bacterial-type flagellum-dependent cell motility
D9T18_RS11750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9T18_RS11755	COG4786	Flagellar basal body rod
D9T18_RS11760	COG4786	Flagellar basal body rod
D9T18_RS11780	COG1815	bacterial-type flagellum-dependent cell motility
D9T18_RS11785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9T18_RS11790	COG0835	chemotaxis
D9T18_RS11790	COG0784	Response regulator, receiver
D9T18_RS11825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS11830	COG2197	response regulator
D9T18_RS11835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D9T18_RS11860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D9T18_RS11860	COG0678	peroxiredoxin activity
D9T18_RS11920	COG0582	viral genome integration into host DNA
D9T18_RS11960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9T18_RS11965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D9T18_RS11970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D9T18_RS11975	COG0730	response to heat
D9T18_RS11985	COG1051	belongs to the nudix hydrolase family
D9T18_RS11990	COG3066	DNA modification
D9T18_RS12000	COG0148	phosphopyruvate hydratase activity
D9T18_RS12005	COG0504	CTP synthase activity
D9T18_RS12010	COG3956	TIGRFAM MazG family protein
D9T18_RS12015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9T18_RS12020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9T18_RS12025	COG2205	protein histidine kinase activity
D9T18_RS12025	COG3850	Histidine kinase
D9T18_RS12025	COG4999	Histidine kinase
D9T18_RS12025	COG3437	response regulator, receiver
D9T18_RS12030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D9T18_RS12035	COG1381	Involved in DNA repair and RecF pathway recombination
D9T18_RS12045	COG0571	ribonuclease III activity
D9T18_RS12055	COG0481	GTPase activity
D9T18_RS12065	COG3026	antisigma factor binding
D9T18_RS12075	COG1595	DNA-templated transcription, initiation
D9T18_RS12080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D9T18_RS12090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D9T18_RS12100	COG1047	Peptidyl-prolyl cis-trans
D9T18_RS12115	COG3099	Belongs to the UPF0263 family
D9T18_RS12125	COG1024	Enoyl-CoA hydratase
D9T18_RS12135	COG1346	cytolysis
D9T18_RS12140	COG0668	transmembrane transport
D9T18_RS12145	COG2239	Acts as a magnesium transporter
D9T18_RS12165	COG0840	transmembrane signaling receptor activity
D9T18_RS12195	COG0788	formyltetrahydrofolate deformylase activity
D9T18_RS12200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D9T18_RS12210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9T18_RS12220	COG4773	Receptor
D9T18_RS12235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9T18_RS12255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9T18_RS12260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D9T18_RS12265	COG0585	pseudouridine synthase activity
D9T18_RS12270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D9T18_RS12275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D9T18_RS12280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D9T18_RS12310	COG2944	sequence-specific DNA binding
D9T18_RS12315	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D9T18_RS12320	COG0454	-acetyltransferase
D9T18_RS12335	COG3123	guanosine phosphorylase activity
D9T18_RS12340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9T18_RS12345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9T18_RS12355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9T18_RS12360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D9T18_RS12365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9T18_RS12390	COG0560	Phosphoserine phosphatase
D9T18_RS12400	COG0084	hydrolase, TatD family'
D9T18_RS12405	COG0259	pyridoxamine-phosphate oxidase activity
D9T18_RS12410	COG0018	arginyl-trna synthetase
D9T18_RS12415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D9T18_RS12440	COG0784	Response regulator, receiver
D9T18_RS12440	COG2205	protein histidine kinase activity
D9T18_RS12445	COG0456	acetyltransferase
D9T18_RS12460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9T18_RS12465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9T18_RS12465	COG0519	Catalyzes the synthesis of GMP from XMP
D9T18_RS12470	COG0516	GMP reductase activity
D9T18_RS12470	COG0517	IMP dehydrogenase activity
D9T18_RS12475	COG1570	exodeoxyribonuclease VII activity
D9T18_RS12485	COG1045	serine acetyltransferase
D9T18_RS12490	COG5001	Diguanylate cyclase
D9T18_RS12490	COG3706	GGDEF domain
D9T18_RS12490	COG2203	Gaf domain
D9T18_RS12490	COG4251	negative regulation of phosphorylation
D9T18_RS12505	COG0612	Peptidase, M16
D9T18_RS12515	COG2199	diguanylate cyclase activity
D9T18_RS12515	COG2203	Gaf domain
D9T18_RS12520	COG0513	Belongs to the DEAD box helicase family
D9T18_RS12540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9T18_RS12560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9T18_RS12585	COG0745	RESPONSE REGULATOR receiver
D9T18_RS12590	COG0642	Histidine kinase
D9T18_RS12595	COG0617	tRNA 3'-terminal CCA addition
D9T18_RS12610	COG2204	response regulator
D9T18_RS12620	COG2205	protein histidine kinase activity
D9T18_RS12645	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D9T18_RS12670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9T18_RS12675	COG1489	DNA binding
D9T18_RS12695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9T18_RS12700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9T18_RS12705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D9T18_RS12720	COG5002	protein histidine kinase activity
D9T18_RS12725	COG0745	RESPONSE REGULATOR receiver
D9T18_RS12735	COG0126	phosphoglycerate kinase activity
D9T18_RS12740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9T18_RS12765	COG0516	GMP reductase activity
D9T18_RS12765	COG0517	IMP dehydrogenase activity
D9T18_RS12770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9T18_RS12780	COG0784	Response regulator, receiver
D9T18_RS12780	COG2205	protein histidine kinase activity
D9T18_RS12795	COG3706	GGDEF domain
D9T18_RS12845	COG3250	beta-galactosidase activity
D9T18_RS12850	COG2259	Doxx family
D9T18_RS12900	COG0596	Alpha beta hydrolase
D9T18_RS12925	COG2819	hydrolase of the alpha beta superfamily
D9T18_RS12930	COG0793	Belongs to the peptidase S41A family
D9T18_RS12940	COG2205	protein histidine kinase activity
D9T18_RS12945	COG0745	RESPONSE REGULATOR receiver
D9T18_RS12950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T18_RS12975	COG4771	TonB-dependent receptor
D9T18_RS12995	COG3842	ATPase activity
D9T18_RS13005	COG3665	Urea carboxylase-associated protein
D9T18_RS13020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D9T18_RS13025	COG0534	Mate efflux family protein
D9T18_RS13030	COG0583	DNA-binding transcription factor activity
D9T18_RS13055	COG3791	Glutathione-dependent formaldehyde-activating
D9T18_RS13060	COG0753	catalase activity
D9T18_RS13065	COG0668	transmembrane transport
D9T18_RS13085	COG0783	Belongs to the Dps family
D9T18_RS13100	COG0625	glutathione transferase activity
D9T18_RS13115	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D9T18_RS13125	COG4572	Cation transport regulator
D9T18_RS13200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9T18_RS13200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9T18_RS13205	COG0509	glycine decarboxylation via glycine cleavage system
D9T18_RS13210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9T18_RS13220	COG0583	DNA-binding transcription factor activity
D9T18_RS13225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9T18_RS13230	COG0557	exoribonuclease II activity
D9T18_RS13235	COG2197	response regulator
D9T18_RS13240	COG4585	Histidine kinase
D9T18_RS13250	COG0584	glycerophosphoryl diester phosphodiesterase
D9T18_RS13270	COG0784	Response regulator, receiver
D9T18_RS13270	COG5002	protein histidine kinase activity
D9T18_RS13275	COG1247	-acetyltransferase
D9T18_RS13290	COG0625	glutathione transferase activity
D9T18_RS13320	COG3954	Phosphoribulokinase
D9T18_RS13325	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D9T18_RS13330	COG1011	Hydrolase
D9T18_RS13335	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D9T18_RS13340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9T18_RS13345	COG0849	cell division
D9T18_RS13350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9T18_RS13355	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9T18_RS13360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9T18_RS13365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9T18_RS13370	COG0772	Belongs to the SEDS family
D9T18_RS13375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9T18_RS13380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9T18_RS13385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D9T18_RS13390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9T18_RS13395	COG0768	penicillin binding
D9T18_RS13400	COG3116	cell division
D9T18_RS13405	COG0275	rRNA processing
D9T18_RS13410	COG2001	Belongs to the MraZ family
D9T18_RS13430	COG0435	Glutathione S-transferase
D9T18_RS13435	COG1741	Belongs to the pirin family
D9T18_RS13445	COG0583	DNA-binding transcription factor activity
D9T18_RS13450	COG1295	ribonuclease BN
D9T18_RS13460	COG1301	dicarboxylic acid transport
D9T18_RS13470	COG4191	Histidine kinase
D9T18_RS13470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T18_RS13475	COG2204	response regulator
D9T18_RS13480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9T18_RS13495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9T18_RS13500	COG3107	peptidoglycan biosynthetic process
D9T18_RS13505	COG0792	nuclease activity
D9T18_RS13515	COG2823	Periplasmic or secreted lipoprotein
D9T18_RS13520	COG2969	positive regulation of protein catabolic process
D9T18_RS13525	COG0625	glutathione transferase activity
D9T18_RS13530	COG2857	Cytochrome c1
D9T18_RS13535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9T18_RS13540	COG0723	plastoquinol--plastocyanin reductase activity
D9T18_RS13545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9T18_RS13550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9T18_RS13555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D9T18_RS13565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9T18_RS13575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9T18_RS13580	COG5007	Belongs to the BolA IbaG family
D9T18_RS13590	COG2854	intermembrane phospholipid transfer
D9T18_RS13595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D9T18_RS13600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9T18_RS13605	COG1127	ABC transporter
D9T18_RS13615	COG0517	IMP dehydrogenase activity
D9T18_RS13615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D9T18_RS13620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D9T18_RS13635	COG1137	ATPase activity
D9T18_RS13640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9T18_RS13655	COG1660	Displays ATPase and GTPase activities
D9T18_RS13660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9T18_RS13665	COG2239	Acts as a magnesium transporter
D9T18_RS13675	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D9T18_RS13690	COG3562	capsule polysaccharide
D9T18_RS13705	COG3300	MHYT domain
D9T18_RS13705	COG5001	Diguanylate cyclase
D9T18_RS13715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9T18_RS13725	COG1136	(ABC) transporter
D9T18_RS13740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9T18_RS13750	COG1227	inorganic diphosphatase activity
D9T18_RS13760	COG2095	MarC family integral membrane protein
D9T18_RS13765	COG0735	belongs to the Fur family
D9T18_RS13775	COG0432	Pfam Uncharacterised protein family UPF0047
D9T18_RS13795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D9T18_RS13800	COG1162	GTPase activity
D9T18_RS13805	COG0688	phosphatidylethanolamine metabolic process
D9T18_RS13810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9T18_RS13820	COG2022	thiamine diphosphate biosynthetic process
D9T18_RS13835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9T18_RS13850	COG1629	transport
D9T18_RS13850	COG4774	siderophore transport
D9T18_RS13860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D9T18_RS13865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9T18_RS13895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9T18_RS13900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D9T18_RS13910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9T18_RS13920	COG2003	Belongs to the UPF0758 family
D9T18_RS13925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9T18_RS13935	COG1506	peptidase
D9T18_RS13935	COG0823	Involved in the tonB-independent uptake of proteins
D9T18_RS13935	COG4946	Tricorn protease homolog
D9T18_RS13965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9T18_RS13985	COG1522	sequence-specific DNA binding
D9T18_RS14005	COG2081	HI0933 family
D9T18_RS14010	COG1404	Belongs to the peptidase S8 family
D9T18_RS14015	COG0678	peroxiredoxin activity
D9T18_RS14035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9T18_RS14040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D9T18_RS14045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9T18_RS14050	COG0142	geranyltranstransferase activity
D9T18_RS14055	COG0039	L-malate dehydrogenase activity
D9T18_RS14060	COG1438	arginine binding
D9T18_RS14080	COG1840	ABC-type Fe3 transport system, periplasmic component
D9T18_RS14085	COG3148	PFAM DTW domain containing protein
D9T18_RS14095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9T18_RS14100	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9T18_RS14105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D9T18_RS14110	COG2186	Transcriptional regulator
D9T18_RS14115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D9T18_RS14140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D9T18_RS14145	COG0237	dephospho-CoA kinase activity
D9T18_RS14150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T18_RS14155	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D9T18_RS14165	COG0745	RESPONSE REGULATOR receiver
D9T18_RS14170	COG2205	protein histidine kinase activity
D9T18_RS14175	COG2267	carboxylic ester hydrolase activity
D9T18_RS14185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9T18_RS14190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9T18_RS14195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D9T18_RS14200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D9T18_RS14205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9T18_RS14210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9T18_RS14215	COG4942	peptidase
D9T18_RS14220	COG0793	Belongs to the peptidase S41A family
D9T18_RS14235	COG2177	Part of the ABC transporter FtsEX involved in
D9T18_RS14240	COG2884	Cell division ATP-binding protein ftsE
D9T18_RS14245	COG0552	protein localization to endoplasmic reticulum
D9T18_RS14250	COG0742	ribosomal rna small subunit methyltransferase
D9T18_RS14255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9T18_RS14275	COG2264	protein methyltransferase activity
D9T18_RS14280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9T18_RS14285	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D9T18_RS14290	COG0138	bifunctional purine biosynthesis protein purh
D9T18_RS14300	COG0151	Belongs to the GarS family
D9T18_RS14305	COG5001	Diguanylate cyclase
D9T18_RS14320	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9T18_RS14335	COG1280	lysine exporter protein (LysE YggA)
D9T18_RS14395	COG0583	DNA-binding transcription factor activity
D9T18_RS14430	COG2823	Periplasmic or secreted lipoprotein
D9T18_RS14460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9T18_RS14465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9T18_RS14470	COG1862	Preprotein translocase
D9T18_RS14475	COG0343	queuine tRNA-ribosyltransferase activity
D9T18_RS14480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9T18_RS14485	COG5002	protein histidine kinase activity
D9T18_RS14485	COG5001	Diguanylate cyclase
D9T18_RS14495	COG0583	DNA-binding transcription factor activity
D9T18_RS14500	COG0306	phosphate transporter
D9T18_RS14505	COG1392	Phosphate transport regulator
D9T18_RS14510	COG0704	Plays a role in the regulation of phosphate uptake
D9T18_RS14515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9T18_RS14520	COG0573	inorganic phosphate transmembrane transporter activity
D9T18_RS14535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D9T18_RS14540	COG0248	Ppx GppA phosphatase
D9T18_RS14550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T18_RS14555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS14575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T18_RS14595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D9T18_RS14615	COG1388	LysM domain
D9T18_RS14615	COG0741	lytic transglycosylase activity
D9T18_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS14640	COG4948	Mandelate Racemase Muconate Lactonizing
D9T18_RS14685	COG0784	Response regulator, receiver
D9T18_RS14685	COG2205	protein histidine kinase activity
D9T18_RS14685	COG5002	protein histidine kinase activity
D9T18_RS14695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D9T18_RS14700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9T18_RS14710	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D9T18_RS14715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9T18_RS14720	COG0330	HflC and HflK could
D9T18_RS14725	COG0330	HflC and HflK could
D9T18_RS14730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9T18_RS14735	COG1923	regulation of RNA biosynthetic process
D9T18_RS14740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9T18_RS14745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9T18_RS14750	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9T18_RS14755	COG0802	atpase or kinase
D9T18_RS14760	COG0439	Biotin carboxylase
D9T18_RS14765	COG0511	ligase activity, forming carbon-carbon bonds
D9T18_RS14770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D9T18_RS14775	COG4232	protein-disulfide reductase activity
D9T18_RS14780	COG1324	tolerance protein
D9T18_RS14785	COG3030	protein affecting phage T7 exclusion by the F plasmid
D9T18_RS14790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D9T18_RS14795	COG0459	protein refolding
D9T18_RS14805	COG0346	lactoylglutathione lyase activity
D9T18_RS14810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9T18_RS14810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D9T18_RS14835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9T18_RS14840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9T18_RS14845	COG1561	YicC-like family, N-terminal region
D9T18_RS14855	COG2197	response regulator
D9T18_RS14860	COG4585	Histidine kinase
D9T18_RS14865	COG0515	serine threonine protein kinase
D9T18_RS14865	COG2815	serine threonine protein kinase
D9T18_RS14880	COG1404	Belongs to the peptidase S8 family
D9T18_RS14885	COG0194	GDP metabolic process
D9T18_RS14890	COG1758	RNA polymerase activity
D9T18_RS14895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9T18_RS14915	COG1522	sequence-specific DNA binding
D9T18_RS14920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9T18_RS14925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9T18_RS14955	COG0724	RNA recognition motif
D9T18_RS14960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9T18_RS14970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9T18_RS14975	COG1683	Conserved Protein
D9T18_RS14990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9T18_RS15040	COG2165	general secretion pathway protein
D9T18_RS15050	COG2165	general secretion pathway protein
D9T18_RS15055	COG1459	type II secretion system
D9T18_RS15060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9T18_RS15070	COG3031	protein transport across the cell outer membrane
D9T18_RS15080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9T18_RS15085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D9T18_RS15110	COG0203	ribosomal protein L17
D9T18_RS15115	COG0202	RNA polymerase activity
D9T18_RS15120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9T18_RS15125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D9T18_RS15130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9T18_RS15135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9T18_RS15140	COG0201	protein transport
D9T18_RS15145	COG0200	Binds to the 23S rRNA
D9T18_RS15150	COG1841	ribosomal large subunit assembly
D9T18_RS15155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D9T18_RS15160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D9T18_RS15165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9T18_RS15170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9T18_RS15175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9T18_RS15180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9T18_RS15185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9T18_RS15190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D9T18_RS15215	COG4555	ABC transporter
D9T18_RS15225	COG0640	Transcriptional regulator
D9T18_RS15250	COG3713	MltA-interacting MipA family protein
D9T18_RS15280	COG1132	(ABC) transporter
D9T18_RS15285	COG2885	chlorophyll binding
D9T18_RS15295	COG0668	transmembrane transport
D9T18_RS15300	COG0204	Acyl-transferase
D9T18_RS15305	COG0204	Acyl-transferase
D9T18_RS15310	COG1166	arginine decarboxylase activity
D9T18_RS15315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9T18_RS15330	COG1082	Xylose isomerase domain protein TIM barrel
D9T18_RS15345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9T18_RS15360	COG2183	response to ionizing radiation
D9T18_RS15380	COG1040	competence protein
D9T18_RS15390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9T18_RS15390	COG0316	Belongs to the HesB IscA family
D9T18_RS15400	COG0534	Mate efflux family protein
D9T18_RS15405	COG0726	polysaccharide deacetylase
D9T18_RS15410	COG2201	protein-glutamate methylesterase activity
D9T18_RS15415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9T18_RS15420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9T18_RS15430	COG0835	chemotaxis
D9T18_RS15435	COG0643	Histidine kinase
D9T18_RS15435	COG2198	Histidine kinase
D9T18_RS15455	COG0109	protoheme IX farnesyltransferase activity
D9T18_RS15460	COG1612	heme a metabolic process
D9T18_RS15485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D9T18_RS15490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9T18_RS15545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9T18_RS15545	COG1017	nitric oxide dioxygenase activity
D9T18_RS15560	COG3604	Transcriptional regulator
D9T18_RS15565	COG0583	DNA-binding transcription factor activity
D9T18_RS15570	COG0431	NADPH-dependent FMN reductase
D9T18_RS15600	COG0066	3-isopropylmalate dehydratase activity
D9T18_RS15605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9T18_RS15610	COG0473	3-isopropylmalate dehydrogenase activity
D9T18_RS15615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9T18_RS15630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9T18_RS15635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D9T18_RS15640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D9T18_RS15645	COG0545	Peptidyl-prolyl cis-trans isomerase
D9T18_RS15655	COG2900	Belongs to the SlyX family
D9T18_RS15660	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D9T18_RS15665	COG0488	(ABC) transporter
D9T18_RS15680	COG0429	hydrolase of the alpha beta-hydrolase fold
D9T18_RS15685	COG3089	Belongs to the UPF0270 family
D9T18_RS15725	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D9T18_RS15735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9T18_RS15750	COG0537	adenosine 5'-monophosphoramidase activity
D9T18_RS15775	COG0436	Aminotransferase
D9T18_RS15780	COG0235	Class ii aldolase
D9T18_RS15785	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D9T18_RS15795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9T18_RS15800	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D9T18_RS15805	COG0069	glutamate synthase activity
D9T18_RS15815	COG3447	MASE1 domain protein
D9T18_RS15815	COG5002	protein histidine kinase activity
D9T18_RS15815	COG5001	Diguanylate cyclase
D9T18_RS15820	COG2226	methyltransferase
D9T18_RS15835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9T18_RS15840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9T18_RS15845	COG0805	protein transport
D9T18_RS15860	COG2203	Gaf domain
D9T18_RS15860	COG5001	Diguanylate cyclase
D9T18_RS15860	COG4251	negative regulation of phosphorylation
D9T18_RS15860	COG3706	GGDEF domain
D9T18_RS15875	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D9T18_RS15885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9T18_RS15910	COG0783	Belongs to the Dps family
D9T18_RS15915	COG4206	TonB-dependent receptor
D9T18_RS15930	COG1770	oligopeptidase
D9T18_RS15935	COG3397	chitin binding
D9T18_RS15990	COG3428	Bacterial PH domain
D9T18_RS16015	COG2832	Protein of unknown function (DUF454)
D9T18_RS16070	COG4771	TonB-dependent receptor
D9T18_RS16075	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9T18_RS16085	COG0730	response to heat
D9T18_RS16090	COG2188	Transcriptional regulator
D9T18_RS16095	COG0656	L-ascorbic acid biosynthetic process
D9T18_RS16105	COG2855	membrane
D9T18_RS16130	COG4771	TonB-dependent receptor
D9T18_RS16140	COG4946	Tricorn protease homolog
D9T18_RS16140	COG0793	Belongs to the peptidase S41A family
D9T18_RS16145	COG0513	Belongs to the DEAD box helicase family
D9T18_RS16155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9T18_RS16160	COG1349	DNA-binding transcription factor activity
D9T18_RS16165	COG0110	maltose O-acetyltransferase activity
D9T18_RS16200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D9T18_RS16205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9T18_RS16210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9T18_RS16215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9T18_RS16220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9T18_RS16225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9T18_RS16230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9T18_RS16240	COG0356	it plays a direct role in the translocation of protons across the membrane
D9T18_RS16250	COG1475	DNA binding
D9T18_RS16255	COG1192	Involved in chromosome partitioning
D9T18_RS16260	COG0357	Ribosomal RNA small subunit methyltransferase G
D9T18_RS16265	COG0445	tRNA wobble uridine modification
D9T18_RS16270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9T18_RS16275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D9T18_RS16280	COG0706	membrane insertase activity
D9T18_RS16285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9T18_RS16290	COG0594	ribonuclease P activity
D9T18_RS16295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D9T18_RS16300	COG2207	Transcriptional regulator
D9T18_RS16305	COG4303	Ethanolamine ammonia lyase large subunit
D9T18_RS16310	COG4302	ethanolamine ammonia-lyase activity
D9T18_RS16315	COG0531	amino acid
D9T18_RS16330	COG1252	NADH dehydrogenase
D9T18_RS16335	COG0514	ATP-dependent DNA helicase (RecQ)
D9T18_RS16350	COG2130	NADP-dependent
D9T18_RS16360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D9T18_RS16375	COG1086	Polysaccharide biosynthesis protein
D9T18_RS16415	COG0583	DNA-binding transcription factor activity
D9T18_RS16420	COG2855	membrane
D9T18_RS16425	COG0415	Belongs to the DNA photolyase family
D9T18_RS16435	COG3710	Transcriptional regulator
D9T18_RS16455	COG1160	GTP binding
D9T18_RS16460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9T18_RS16465	COG2976	Protein conserved in bacteria
D9T18_RS16470	COG0124	histidyl-tRNA synthetase
D9T18_RS16475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9T18_RS16490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9T18_RS16495	COG0105	UTP biosynthetic process
D9T18_RS16500	COG0826	peptidase U32
D9T18_RS16505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D9T18_RS16545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9T18_RS16550	COG0745	RESPONSE REGULATOR receiver
D9T18_RS16555	COG1279	arginine transmembrane transporter activity
D9T18_RS16590	COG2161	toxin-antitoxin pair type II binding
D9T18_RS16595	COG4115	mRNA cleavage
D9T18_RS16610	COG0668	transmembrane transport
D9T18_RS16615	COG3724	N-succinylarginine dihydrolase activity
D9T18_RS16625	COG0604	alcohol dehydrogenase
D9T18_RS16630	COG0583	DNA-binding transcription factor activity
D9T18_RS16635	COG1846	Transcriptional regulator
D9T18_RS16640	COG1764	response to oxidative stress
D9T18_RS16650	COG1017	nitric oxide dioxygenase activity
D9T18_RS16650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9T18_RS16655	COG0625	glutathione transferase activity
D9T18_RS16665	COG0640	Transcriptional regulator
D9T18_RS16670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9T18_RS16685	COG1309	transcriptional regulator
D9T18_RS16710	COG0705	Rhomboid family
D9T18_RS16720	COG0789	Transcriptional regulator
D9T18_RS16740	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D9T18_RS16815	COG0402	S-adenosylhomocysteine deaminase activity
D9T18_RS16820	COG2351	hydroxyisourate hydrolase activity
D9T18_RS16835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9T18_RS16845	COG3845	ABC transporter
D9T18_RS16850	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9T18_RS16855	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9T18_RS16865	COG2233	PERMEase
D9T18_RS16875	COG4771	TonB-dependent receptor
D9T18_RS16895	COG1979	alcohol dehydrogenase
D9T18_RS16925	COG2860	membrane
D9T18_RS16965	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D9T18_RS16975	COG0515	serine threonine protein kinase
D9T18_RS16985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D9T18_RS16990	COG0730	response to heat
D9T18_RS17010	COG1309	transcriptional regulator
D9T18_RS17030	COG0753	catalase activity
D9T18_RS17035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9T18_RS17045	COG0246	Mannitol dehydrogenase
D9T18_RS17050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9T18_RS17055	COG1966	Carbon starvation protein
D9T18_RS17095	COG1609	Transcriptional regulator
D9T18_RS17150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9T18_RS17155	COG4136	ATPase activity
D9T18_RS17165	COG4134	Bacterial extracellular solute-binding protein
D9T18_RS17225	COG0604	alcohol dehydrogenase
D9T18_RS17240	COG1609	Transcriptional regulator
D9T18_RS17250	COG1280	lysine exporter protein (LysE YggA)
D9T18_RS17280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9T18_RS17305	COG0457	Tetratricopeptide repeat
D9T18_RS17310	COG4771	TonB-dependent receptor
D9T18_RS17315	COG1902	pentaerythritol trinitrate reductase activity
D9T18_RS17320	COG2814	Major facilitator Superfamily
D9T18_RS17330	COG2186	Transcriptional regulator
D9T18_RS17335	COG0673	inositol 2-dehydrogenase activity
D9T18_RS17370	COG3634	alkyl hydroperoxide reductase activity
D9T18_RS17380	COG0784	Response regulator, receiver
D9T18_RS17380	COG2205	protein histidine kinase activity
D9T18_RS17405	COG4667	esterase of the alpha-beta hydrolase superfamily
D9T18_RS17425	COG3706	GGDEF domain
D9T18_RS17425	COG4251	negative regulation of phosphorylation
D9T18_RS17425	COG5001	Diguanylate cyclase
D9T18_RS17425	COG2203	Gaf domain
D9T18_RS17445	COG0840	transmembrane signaling receptor activity
D9T18_RS17515	COG5002	protein histidine kinase activity
D9T18_RS17520	COG0745	RESPONSE REGULATOR receiver
D9T18_RS17525	COG2132	Multicopper oxidase
D9T18_RS17540	COG1276	copper resistance
D9T18_RS17565	COG2119	membrane
D9T18_RS17595	COG0789	Transcriptional regulator
D9T18_RS17605	COG1230	cation diffusion facilitator family transporter
D9T18_RS17615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS17630	COG2226	methyltransferase
D9T18_RS17660	COG2906	2 iron, 2 sulfur cluster binding
D9T18_RS17665	COG2193	ferroxidase activity
D9T18_RS17670	COG2193	ferroxidase activity
D9T18_RS17680	COG5002	protein histidine kinase activity
D9T18_RS17680	COG2205	protein histidine kinase activity
D9T18_RS17680	COG0784	Response regulator, receiver
D9T18_RS17695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9T18_RS17705	COG1435	thymidine kinase activity
D9T18_RS17710	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D9T18_RS17715	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D9T18_RS17725	COG0457	Tetratricopeptide repeat
D9T18_RS17745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9T18_RS17750	COG0346	lactoylglutathione lyase activity
D9T18_RS17755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9T18_RS17770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D9T18_RS17780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9T18_RS17840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D9T18_RS17845	COG0295	cytidine deaminase activity
D9T18_RS17850	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D9T18_RS17855	COG0010	Belongs to the arginase family
D9T18_RS17865	COG1253	flavin adenine dinucleotide binding
D9T18_RS17870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS17915	COG1595	DNA-templated transcription, initiation
D9T18_RS17920	COG1597	lipid kinase activity
D9T18_RS17920	COG1803	Methylglyoxal synthase
D9T18_RS17925	COG4628	conserved protein (DUF2132)
D9T18_RS17940	COG0625	glutathione transferase activity
D9T18_RS17945	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D9T18_RS17995	COG1757	Na H antiporter
D9T18_RS18010	COG3008	intermembrane lipid transfer
D9T18_RS18010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D9T18_RS18015	COG2995	paraquat-inducible protein a
D9T18_RS18030	COG0443	Heat shock 70 kDa protein
D9T18_RS18035	COG0484	heat shock protein binding
D9T18_RS18050	COG2205	protein histidine kinase activity
D9T18_RS18050	COG0784	Response regulator, receiver
D9T18_RS18050	COG2198	Histidine kinase
D9T18_RS18050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T18_RS18065	COG4191	Histidine kinase
D9T18_RS18085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9T18_RS18120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9T18_RS18135	COG1064	alcohol dehydrogenase
D9T18_RS18140	COG1960	acyl-CoA dehydrogenase activity
D9T18_RS18175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9T18_RS18180	COG2233	PERMEase
D9T18_RS18185	COG3769	mannosylglycerate metabolic process
D9T18_RS18190	COG1215	transferase activity, transferring glycosyl groups
D9T18_RS18195	COG0366	Alpha amylase catalytic
D9T18_RS18200	COG4206	TonB-dependent receptor
D9T18_RS18205	COG4771	TonB-dependent receptor
D9T18_RS18220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9T18_RS18225	COG0254	rRNA binding
D9T18_RS18240	COG0583	DNA-binding transcription factor activity
D9T18_RS18245	COG2814	Major facilitator Superfamily
D9T18_RS18250	COG0656	L-ascorbic acid biosynthetic process
D9T18_RS18265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9T18_RS18280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9T18_RS18285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9T18_RS18315	COG2986	histidine ammonia-lyase
D9T18_RS18350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9T18_RS18355	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS18365	COG0513	Belongs to the DEAD box helicase family
D9T18_RS18370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D9T18_RS18375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D9T18_RS18410	COG1012	belongs to the aldehyde dehydrogenase family
D9T18_RS18415	COG1309	transcriptional regulator
D9T18_RS18450	COG1012	belongs to the aldehyde dehydrogenase family
D9T18_RS18460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9T18_RS18465	COG1522	sequence-specific DNA binding
D9T18_RS18490	COG1640	4-alpha-glucanotransferase
D9T18_RS18495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9T18_RS18505	COG0058	SHG alpha-glucan phosphorylase activity
D9T18_RS18510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9T18_RS18515	COG0297	glycogen (starch) synthase activity
D9T18_RS18520	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9T18_RS18525	COG2311	Membrane
D9T18_RS18530	COG1187	pseudouridine synthase activity
D9T18_RS18550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9T18_RS18575	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS18580	COG1272	protein, Hemolysin III
D9T18_RS18600	COG1595	DNA-templated transcription, initiation
D9T18_RS18615	COG0415	Belongs to the DNA photolyase family
D9T18_RS18625	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS18640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D9T18_RS18665	COG0440	acetolactate synthase activity
D9T18_RS18670	COG0028	Belongs to the TPP enzyme family
D9T18_RS18680	COG0473	3-isopropylmalate dehydrogenase activity
D9T18_RS18695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9T18_RS18700	COG1611	Belongs to the LOG family
D9T18_RS18720	COG2873	o-acetylhomoserine
D9T18_RS18735	COG3306	glycosyltransferase involved in LPS biosynthesis
D9T18_RS18750	COG0140	phosphoribosyl-ATP diphosphatase activity
D9T18_RS18750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9T18_RS18755	COG0107	imidazoleglycerol-phosphate synthase activity
D9T18_RS18760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9T18_RS18765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9T18_RS18770	COG0131	Imidazoleglycerol-phosphate dehydratase
D9T18_RS18770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9T18_RS18775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9T18_RS18780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9T18_RS18785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D9T18_RS18795	COG0672	)-iron permease
D9T18_RS18805	COG1199	ATP-dependent helicase activity
D9T18_RS18820	COG1785	Belongs to the alkaline phosphatase family
D9T18_RS18830	COG0318	PFAM AMP-dependent synthetase and ligase
D9T18_RS18845	COG0564	pseudouridine synthase activity
D9T18_RS18860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D9T18_RS18865	COG2894	cell division
D9T18_RS18870	COG0850	regulation of cytokinetic process
D9T18_RS18875	COG3100	YcgL domain-containing protein
D9T18_RS18880	COG2951	lytic endotransglycosylase activity
D9T18_RS18905	COG2983	Belongs to the UPF0260 family
D9T18_RS18945	COG0811	peptide transport
D9T18_RS18950	COG0811	peptide transport
D9T18_RS18955	COG0848	biopolymer transport protein
D9T18_RS18960	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D9T18_RS19000	COG1061	Type III restriction enzyme res subunit
D9T18_RS19035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D9T18_RS19090	COG4895	conserved protein (DUF2196)
D9T18_RS19100	COG3227	Zinc metalloprotease (Elastase)
D9T18_RS19130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9T18_RS19135	COG4667	esterase of the alpha-beta hydrolase superfamily
D9T18_RS19145	COG2169	Transcriptional regulator
D9T18_RS19155	COG2423	ornithine cyclodeaminase activity
D9T18_RS19165	COG1115	amino acid carrier protein
D9T18_RS19190	COG3263	regulation of cellular component size
D9T18_RS19195	COG0247	lactate metabolic process
D9T18_RS19195	COG0277	FAD linked oxidase domain protein
D9T18_RS19205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D9T18_RS19210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D9T18_RS19235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9T18_RS19240	COG1322	Protein conserved in bacteria
D9T18_RS19260	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9T18_RS19260	COG1902	pentaerythritol trinitrate reductase activity
D9T18_RS19265	COG1794	racemase activity, acting on amino acids and derivatives
D9T18_RS19270	COG0583	DNA-binding transcription factor activity
D9T18_RS19280	COG0583	DNA-binding transcription factor activity
D9T18_RS19285	COG0583	DNA-binding transcription factor activity
D9T18_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS19295	COG3384	dioxygenase
D9T18_RS19315	COG2200	EAL domain
D9T18_RS19325	COG0076	glutamate decarboxylase activity
D9T18_RS19330	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D9T18_RS19340	COG4264	IucA IucC family
D9T18_RS19360	COG0583	DNA-binding transcription factor activity
D9T18_RS19385	COG3118	belongs to the thioredoxin family
D9T18_RS19390	COG0492	ferredoxin-NADP+ reductase activity
D9T18_RS19395	COG1309	transcriptional regulator
D9T18_RS19410	COG0583	DNA-binding transcription factor activity
D9T18_RS19415	COG1309	transcriptional regulator
D9T18_RS19425	COG4221	oxidoreductase activity
D9T18_RS19460	COG1028	Short-chain dehydrogenase reductase Sdr
D9T18_RS19465	COG0583	DNA-binding transcription factor activity
D9T18_RS19475	COG2814	Major facilitator Superfamily
D9T18_RS19530	COG1566	PFAM secretion protein HlyD family protein
D9T18_RS19565	COG0300	oxidoreductase activity
D9T18_RS19570	COG1960	acyl-CoA dehydrogenase activity
D9T18_RS19580	COG0385	Bile acid
D9T18_RS19585	COG0318	PFAM AMP-dependent synthetase and ligase
D9T18_RS19600	COG4771	TonB-dependent receptor
D9T18_RS19610	COG1573	uracil-dna glycosylase
D9T18_RS19635	COG3040	lipid binding
D9T18_RS19640	COG1671	Belongs to the UPF0178 family
D9T18_RS19675	COG0420	3'-5' exonuclease activity
D9T18_RS19705	COG0217	transcriptional regulatory protein
D9T18_RS19725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9T18_RS19735	COG1278	Cold shock
D9T18_RS19750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9T18_RS19755	COG0572	uridine kinase
D9T18_RS19760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D9T18_RS19765	COG0813	purine-nucleoside phosphorylase activity
D9T18_RS19770	COG3547	Transposase (IS116 IS110 IS902 family)
D9T18_RS19775	COG0463	Glycosyl transferase, family 2
D9T18_RS19780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9T18_RS19800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D9T18_RS19805	COG0488	(ABC) transporter
D9T18_RS19850	COG1061	Type III restriction enzyme res subunit
D9T18_RS19900	COG3135	benzoate transporter
D9T18_RS19905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9T18_RS19915	COG4191	Histidine kinase
D9T18_RS19915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9T18_RS19930	COG3038	cytochrome b561
D9T18_RS19990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9T18_RS20065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9T18_RS20135	COG1192	Involved in chromosome partitioning
D9T18_RS20140	COG2356	endonuclease I
D9T18_RS20155	COG0616	signal peptide processing
D9T18_RS20305	COG4974	Belongs to the 'phage' integrase family
D9T18_RS20390	COG4974	Belongs to the 'phage' integrase family
D9T18_RS20510	COG2003	Belongs to the UPF0758 family