locus-tag	class	description
PESP_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PESP_RS00010	COG0592	DNA-directed DNA polymerase activity
PESP_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PESP_RS00020	COG0187	DNA topoisomerase II activity
PESP_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
PESP_RS00030	COG0751	glycine-tRNA ligase activity
PESP_RS00045	COG0425	Belongs to the sulfur carrier protein TusA family
PESP_RS00050	COG0183	Belongs to the thiolase family
PESP_RS00055	COG1250	3-hydroxyacyl-CoA dehydrogenase
PESP_RS00055	COG1024	Enoyl-CoA hydratase
PESP_RS00060	COG0741	lytic transglycosylase activity
PESP_RS00065	COG0006	proline dipeptidase activity
PESP_RS00070	COG1739	Uncharacterized protein family UPF0029
PESP_RS00075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PESP_RS00100	COG0569	domain protein
PESP_RS00105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PESP_RS00105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PESP_RS00110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PESP_RS00115	COG0242	peptide deformylase activity
PESP_RS00125	COG0758	DNA mediated transformation
PESP_RS00130	COG2922	Belongs to the Smg family
PESP_RS00135	COG0551	DNA topoisomerase type I activity
PESP_RS00140	COG0009	L-threonylcarbamoyladenylate synthase
PESP_RS00145	COG0408	coproporphyrinogen oxidase activity
PESP_RS00150	COG2346	COG2346, Truncated hemoglobins
PESP_RS00155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PESP_RS00165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PESP_RS00205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PESP_RS00270	COG0784	Response regulator, receiver
PESP_RS00270	COG2205	protein histidine kinase activity
PESP_RS00290	COG1597	lipid kinase activity
PESP_RS00300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PESP_RS00315	COG0386	Belongs to the glutathione peroxidase family
PESP_RS00320	COG3293	Transposase
PESP_RS00330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PESP_RS00350	COG1404	Belongs to the peptidase S8 family
PESP_RS00355	COG1770	oligopeptidase
PESP_RS00360	COG0784	Response regulator, receiver
PESP_RS00360	COG5002	protein histidine kinase activity
PESP_RS00365	COG0745	RESPONSE REGULATOR receiver
PESP_RS00385	COG1238	metal cluster binding
PESP_RS00390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PESP_RS00395	COG0302	gtp cyclohydrolase
PESP_RS00405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PESP_RS00410	COG3132	Protein of unknown function, DUF480
PESP_RS00415	COG2205	protein histidine kinase activity
PESP_RS00415	COG5002	protein histidine kinase activity
PESP_RS00415	COG0784	Response regulator, receiver
PESP_RS00420	COG1944	ATP diphosphatase activity
PESP_RS00430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PESP_RS00435	COG3153	acetyltransferase
PESP_RS00435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PESP_RS00495	COG1011	Hydrolase
PESP_RS00500	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PESP_RS00510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PESP_RS00515	COG0019	diaminopimelate decarboxylase activity
PESP_RS00525	COG1965	Belongs to the frataxin family
PESP_RS00530	COG0400	carboxylic ester hydrolase activity
PESP_RS00540	COG0181	hydroxymethylbilane synthase activity
PESP_RS00560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PESP_RS00575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PESP_RS00585	COG2354	Protein conserved in bacteria
PESP_RS00600	COG4774	siderophore transport
PESP_RS00605	COG0513	Belongs to the DEAD box helicase family
PESP_RS00615	COG2198	Histidine kinase
PESP_RS00615	COG0784	Response regulator, receiver
PESP_RS00615	COG2205	protein histidine kinase activity
PESP_RS00630	COG3118	belongs to the thioredoxin family
PESP_RS00635	COG0513	Belongs to the DEAD box helicase family
PESP_RS00640	COG0248	Ppx GppA phosphatase
PESP_RS00675	COG1444	tRNA N-acetyltransferase activity
PESP_RS00680	COG0210	DNA helicase
PESP_RS00690	COG3112	Uncharacterised protein family (UPF0231)
PESP_RS00710	COG0717	Belongs to the dCTP deaminase family
PESP_RS00715	COG1011	Hydrolase
PESP_RS00720	COG0494	nUDIX hydrolase
PESP_RS00725	COG1218	3'(2'),5'-bisphosphate nucleotidase
PESP_RS00765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PESP_RS00775	COG3773	Cell wall hydrolase
PESP_RS00775	COG3409	Peptidoglycan-binding domain 1 protein
PESP_RS00785	COG0606	chelatase, subunit chli
PESP_RS00800	COG1253	flavin adenine dinucleotide binding
PESP_RS00815	COG2031	fatty acid transporter
PESP_RS00840	COG1946	Acyl-CoA thioesterase
PESP_RS00845	COG2937	Belongs to the GPAT DAPAT family
PESP_RS00850	COG0051	transcription antitermination factor activity, RNA binding
PESP_RS00855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PESP_RS00860	COG0088	Forms part of the polypeptide exit tunnel
PESP_RS00865	COG0089	rRNA binding
PESP_RS00870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PESP_RS00875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PESP_RS00880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PESP_RS00885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PESP_RS00890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PESP_RS00895	COG0255	Belongs to the universal ribosomal protein uL29 family
PESP_RS00900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PESP_RS00920	COG2356	endonuclease I
PESP_RS00930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PESP_RS00945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PESP_RS00975	COG2204	response regulator
PESP_RS00980	COG3852	Histidine kinase
PESP_RS00990	COG0174	glutamine synthetase
PESP_RS00995	COG1217	gtp-binding protein TYPA
PESP_RS01015	COG1295	ribonuclease BN
PESP_RS01020	COG1490	D-aminoacyl-tRNA deacylase activity
PESP_RS01030	COG0456	acetyltransferase
PESP_RS01045	COG0019	diaminopimelate decarboxylase activity
PESP_RS01055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PESP_RS01065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PESP_RS01075	COG3385	transposase activity
PESP_RS01080	COG1049	propionate catabolic process, 2-methylcitrate cycle
PESP_RS01095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PESP_RS01130	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PESP_RS01140	COG2186	Transcriptional regulator
PESP_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS01150	COG3734	2-keto-3-deoxy-galactonokinase
PESP_RS01155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PESP_RS01175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PESP_RS01185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PESP_RS01190	COG0300	oxidoreductase activity
PESP_RS01205	COG0583	DNA-binding transcription factor activity
PESP_RS01210	COG0604	alcohol dehydrogenase
PESP_RS01210	COG3321	synthase
PESP_RS01215	COG5001	Diguanylate cyclase
PESP_RS01215	COG3300	MHYT domain
PESP_RS01230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PESP_RS01240	COG1012	belongs to the aldehyde dehydrogenase family
PESP_RS01250	COG1765	OsmC-like protein
PESP_RS01255	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PESP_RS01260	COG0814	amino acid
PESP_RS01275	COG1218	3'(2'),5'-bisphosphate nucleotidase
PESP_RS01280	COG0529	Catalyzes the synthesis of activated sulfate
PESP_RS01285	COG3273	potassium ion transport
PESP_RS01285	COG0471	metal ion transport
PESP_RS01290	COG2895	sulfate adenylyltransferase (ATP) activity
PESP_RS01295	COG0175	sulfate reduction
PESP_RS01300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PESP_RS01300	COG1648	precorrin-2 dehydrogenase activity
PESP_RS01305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PESP_RS01320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PESP_RS01325	COG0250	Participates in transcription elongation, termination and antitermination
PESP_RS01330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PESP_RS01335	COG0081	regulation of translation
PESP_RS01340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PESP_RS01345	COG0222	ribosome binding
PESP_RS01350	COG0085	RNA polymerase activity
PESP_RS01355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PESP_RS01360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PESP_RS01365	COG0049	tRNA binding
PESP_RS01370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PESP_RS01375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PESP_RS01395	COG0784	Response regulator, receiver
PESP_RS01395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS01395	COG2198	Histidine kinase
PESP_RS01395	COG2205	protein histidine kinase activity
PESP_RS01400	COG1119	ATPase activity
PESP_RS01420	COG0129	dihydroxy-acid dehydratase activity
PESP_RS01440	COG0288	reversible hydration of carbon dioxide
PESP_RS01445	COG0702	epimerase
PESP_RS01450	COG2960	long-chain fatty acid transporting porin activity
PESP_RS01460	COG5001	Diguanylate cyclase
PESP_RS01470	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PESP_RS01475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PESP_RS01475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PESP_RS01490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PESP_RS01520	COG0312	modulator of DNA gyrase
PESP_RS01530	COG3590	peptidase
PESP_RS01540	COG0494	nUDIX hydrolase
PESP_RS01545	COG0653	protein targeting
PESP_RS01555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PESP_RS01560	COG2986	histidine ammonia-lyase
PESP_RS01565	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PESP_RS01575	COG1228	amidohydrolase
PESP_RS01590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PESP_RS01615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PESP_RS01620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PESP_RS01625	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PESP_RS01630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PESP_RS01635	COG0254	rRNA binding
PESP_RS01640	COG0281	malic enzyme
PESP_RS01645	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
PESP_RS01650	COG0626	cystathionine gamma-synthase activity
PESP_RS01655	COG0527	aspartate kinase activity
PESP_RS01655	COG0460	homoserine dehydrogenase
PESP_RS01660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PESP_RS01690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PESP_RS01695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PESP_RS01705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PESP_RS01720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PESP_RS01730	COG0180	Tryptophanyl-tRNA synthetase
PESP_RS01735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PESP_RS01740	COG2814	Major facilitator Superfamily
PESP_RS01745	COG0629	single-stranded DNA binding
PESP_RS01775	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PESP_RS01790	COG0431	NADPH-dependent FMN reductase
PESP_RS01795	COG0798	PFAM Bile acid sodium symporter
PESP_RS01810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PESP_RS01840	COG3267	Type II secretory pathway component ExeA
PESP_RS01840	COG3409	Peptidoglycan-binding domain 1 protein
PESP_RS01850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PESP_RS01855	COG1459	type II secretion system
PESP_RS01865	COG2165	general secretion pathway protein
PESP_RS01870	COG2165	general secretion pathway protein
PESP_RS01900	COG1077	Cell shape determining protein MreB Mrl
PESP_RS01905	COG1792	Involved in formation and maintenance of cell shape
PESP_RS01910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PESP_RS01915	COG0424	maF-like protein
PESP_RS01920	COG1530	ribonuclease E activity
PESP_RS01925	COG3164	Protein of unknown function
PESP_RS01930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PESP_RS01935	COG0312	modulator of DNA gyrase
PESP_RS01940	COG0668	transmembrane transport
PESP_RS01945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PESP_RS01950	COG0339	signal peptide processing
PESP_RS01955	COG0745	RESPONSE REGULATOR receiver
PESP_RS01960	COG0742	ribosomal rna small subunit methyltransferase
PESP_RS01965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PESP_RS01975	COG1104	cysteine desulfurase activity
PESP_RS01980	COG0822	iron-sulfur transferase activity
PESP_RS01990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PESP_RS01995	COG0443	Heat shock 70 kDa protein
PESP_RS02010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PESP_RS02020	COG1234	tRNA 3'-trailer cleavage
PESP_RS02045	COG0668	transmembrane transport
PESP_RS02050	COG3137	Salt-induced outer membrane protein
PESP_RS02065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PESP_RS02075	COG1215	transferase activity, transferring glycosyl groups
PESP_RS02105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PESP_RS02125	COG2963	transposase activity
PESP_RS02140	COG1596	polysaccharide export
PESP_RS02145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PESP_RS02155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PESP_RS02170	COG0463	Glycosyl transferase, family 2
PESP_RS02170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PESP_RS02190	COG0438	transferase activity, transferring glycosyl groups
PESP_RS02195	COG0438	transferase activity, transferring glycosyl groups
PESP_RS02235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PESP_RS02240	COG0582	viral genome integration into host DNA
PESP_RS02280	COG0542	response to heat
PESP_RS02310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PESP_RS02320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PESP_RS02325	COG1187	pseudouridine synthase activity
PESP_RS02350	COG0848	biopolymer transport protein
PESP_RS02355	COG0811	peptide transport
PESP_RS02370	COG4774	siderophore transport
PESP_RS02375	COG3128	pkhd-type hydroxylase
PESP_RS02380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PESP_RS02405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PESP_RS02410	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PESP_RS02415	COG1227	inorganic diphosphatase activity
PESP_RS02425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PESP_RS02440	COG1136	(ABC) transporter
PESP_RS02450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PESP_RS02460	COG3300	MHYT domain
PESP_RS02460	COG5001	Diguanylate cyclase
PESP_RS02475	COG3562	capsule polysaccharide
PESP_RS02490	COG0688	phosphatidylethanolamine metabolic process
PESP_RS02495	COG1162	GTPase activity
PESP_RS02500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PESP_RS02530	COG0735	belongs to the Fur family
PESP_RS02535	COG2095	MarC family integral membrane protein
PESP_RS02585	COG4128	Pfam Zonular occludens toxin
PESP_RS02605	COG1842	Phage shock protein A
PESP_RS02645	COG3300	MHYT domain
PESP_RS02645	COG5001	Diguanylate cyclase
PESP_RS02650	COG1032	radical SAM domain protein
PESP_RS02655	COG0840	transmembrane signaling receptor activity
PESP_RS02660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PESP_RS02665	COG2967	ApaG domain
PESP_RS02670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PESP_RS02675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PESP_RS02680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PESP_RS02685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PESP_RS02690	COG3178	'Phosphotransferase
PESP_RS02695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PESP_RS02700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PESP_RS02710	COG0564	pseudouridine synthase activity
PESP_RS02730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PESP_RS02735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PESP_RS02740	COG3437	response regulator, receiver
PESP_RS02740	COG3850	Histidine kinase
PESP_RS02740	COG4999	Histidine kinase
PESP_RS02740	COG2205	protein histidine kinase activity
PESP_RS02755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PESP_RS02765	COG3313	Fe-S protein
PESP_RS02790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PESP_RS02795	COG0045	succinate-CoA ligase (ADP-forming) activity
PESP_RS02795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PESP_RS02795	COG1042	CoA-binding domain protein
PESP_RS02815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PESP_RS02820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PESP_RS02830	COG0762	integral membrane protein
PESP_RS02835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PESP_RS02840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PESP_RS02855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PESP_RS02860	COG1678	Uncharacterized ACR, COG1678
PESP_RS02865	COG0189	ligase activity
PESP_RS02870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PESP_RS02885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PESP_RS02895	COG1560	Kdo2-lipid A biosynthetic process
PESP_RS02900	COG1538	Outer membrane efflux protein
PESP_RS02905	COG0494	nUDIX hydrolase
PESP_RS02910	COG3151	Protein conserved in bacteria
PESP_RS02920	COG3150	esterase
PESP_RS02925	COG0187	DNA topoisomerase II activity
PESP_RS02940	COG0204	Acyl-transferase
PESP_RS02945	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PESP_RS02960	COG0189	ligase activity
PESP_RS02960	COG4067	protein conserved in archaea
PESP_RS02965	COG0189	ligase activity
PESP_RS02990	COG0514	ATP-dependent DNA helicase (RecQ)
PESP_RS02995	COG2050	protein possibly involved in aromatic compounds catabolism
PESP_RS03000	COG2962	Rard protein
PESP_RS03010	COG3085	chromosome segregation
PESP_RS03015	COG0583	DNA-binding transcription factor activity
PESP_RS03025	COG1120	ATPase activity
PESP_RS03030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PESP_RS03035	COG1492	cobalamin metabolic process
PESP_RS03040	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PESP_RS03045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PESP_RS03050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PESP_RS03065	COG3022	response to hydroperoxide
PESP_RS03070	COG0668	transmembrane transport
PESP_RS03075	COG0840	transmembrane signaling receptor activity
PESP_RS03085	COG0513	Belongs to the DEAD box helicase family
PESP_RS03090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PESP_RS03095	COG3293	Transposase
PESP_RS03110	COG0583	DNA-binding transcription factor activity
PESP_RS03120	COG0716	FMN binding
PESP_RS03130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PESP_RS03135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PESP_RS03145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PESP_RS03180	COG3876	Protein conserved in bacteria
PESP_RS03185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PESP_RS03190	COG1757	Na H antiporter
PESP_RS03200	COG3293	Transposase
PESP_RS03225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PESP_RS03235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PESP_RS03245	COG2137	regulation of response to DNA damage stimulus
PESP_RS03250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PESP_RS03260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PESP_RS03280	COG3630	sodium ion export across plasma membrane
PESP_RS03295	COG4989	oxidoreductase activity
PESP_RS03305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PESP_RS03315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PESP_RS03325	COG1469	GTP cyclohydrolase I activity
PESP_RS03330	COG0784	Response regulator, receiver
PESP_RS03330	COG5002	protein histidine kinase activity
PESP_RS03330	COG2198	Histidine kinase
PESP_RS03335	COG0745	RESPONSE REGULATOR receiver
PESP_RS03340	COG4191	Histidine kinase
PESP_RS03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS03350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PESP_RS03355	COG1194	a g-specific adenine glycosylase
PESP_RS03360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PESP_RS03420	COG3079	Belongs to the UPF0149 family
PESP_RS03425	COG0006	proline dipeptidase activity
PESP_RS03430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PESP_RS03435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PESP_RS03455	COG0360	Binds together with S18 to 16S ribosomal RNA
PESP_RS03460	COG2965	DNA replication, synthesis of RNA primer
PESP_RS03465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PESP_RS03470	COG0359	binds to the 23S rRNA
PESP_RS03475	COG1595	DNA-templated transcription, initiation
PESP_RS03490	COG0305	Participates in initiation and elongation during chromosome replication
PESP_RS03495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PESP_RS03545	COG0525	valine-tRNA ligase activity
PESP_RS03550	COG2927	DNA polymerase III (CHI subunit)
PESP_RS03555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PESP_RS03560	COG0795	lipopolysaccharide-transporting ATPase activity
PESP_RS03565	COG0795	lipopolysaccharide-transporting ATPase activity
PESP_RS03580	COG5000	phosphorelay sensor kinase activity
PESP_RS03595	COG1136	(ABC) transporter
PESP_RS03630	COG4771	TonB-dependent receptor
PESP_RS03635	COG0583	DNA-binding transcription factor activity
PESP_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS03650	COG0583	DNA-binding transcription factor activity
PESP_RS03655	COG0583	DNA-binding transcription factor activity
PESP_RS03660	COG4989	oxidoreductase activity
PESP_RS03670	COG0737	Belongs to the 5'-nucleotidase family
PESP_RS03675	COG1228	amidohydrolase
PESP_RS03695	COG0251	oxidation-reduction process
PESP_RS03705	COG2807	transmembrane transport
PESP_RS03710	COG2207	Transcriptional regulator
PESP_RS03715	COG4206	TonB-dependent receptor
PESP_RS03760	COG1012	belongs to the aldehyde dehydrogenase family
PESP_RS03765	COG0494	nUDIX hydrolase
PESP_RS03770	COG2204	response regulator
PESP_RS03780	COG4251	negative regulation of phosphorylation
PESP_RS03785	COG0784	Response regulator, receiver
PESP_RS03790	COG2205	protein histidine kinase activity
PESP_RS03790	COG0784	Response regulator, receiver
PESP_RS03795	COG0179	Fumarylacetoacetate (FAA) hydrolase
PESP_RS03805	COG0667	Aldo Keto reductase
PESP_RS03815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PESP_RS03820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PESP_RS03825	COG0840	transmembrane signaling receptor activity
PESP_RS03850	COG2974	May be involved in recombination
PESP_RS03855	COG4191	Histidine kinase
PESP_RS03855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS03860	COG2201	protein-glutamate methylesterase activity
PESP_RS03875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PESP_RS03880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PESP_RS03885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PESP_RS03890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PESP_RS03890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PESP_RS03905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PESP_RS03910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PESP_RS03920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PESP_RS03935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PESP_RS03940	COG0142	geranyltranstransferase activity
PESP_RS03945	COG1722	exodeoxyribonuclease VII activity
PESP_RS03950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PESP_RS03965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PESP_RS03970	COG1473	amidohydrolase
PESP_RS03975	COG3118	belongs to the thioredoxin family
PESP_RS04000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PESP_RS04005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PESP_RS04010	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PESP_RS04015	COG3031	protein transport across the cell outer membrane
PESP_RS04025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PESP_RS04030	COG1459	type II secretion system
PESP_RS04035	COG2165	general secretion pathway protein
PESP_RS04045	COG2165	general secretion pathway protein
PESP_RS04090	COG0348	domain, Protein
PESP_RS04095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PESP_RS04100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PESP_RS04110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PESP_RS04120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PESP_RS04125	COG0724	RNA recognition motif
PESP_RS04150	COG2066	Belongs to the glutaminase family
PESP_RS04155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PESP_RS04165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PESP_RS04170	COG0047	phosphoribosylformylglycinamidine synthase activity
PESP_RS04170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PESP_RS04185	COG3784	Protein of unknown function (DUF1318)
PESP_RS04195	COG1519	Transferase
PESP_RS04200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PESP_RS04205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PESP_RS04205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PESP_RS04225	COG3642	lipopolysaccharide core region biosynthetic process
PESP_RS04230	COG0859	PFAM glycosyl transferase family 9
PESP_RS04235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PESP_RS04245	COG1063	alcohol dehydrogenase
PESP_RS04250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PESP_RS04255	COG0705	Rhomboid family
PESP_RS04260	COG1580	Controls the rotational direction of flagella during chemotaxis
PESP_RS04265	COG3161	chorismate lyase activity
PESP_RS04270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PESP_RS04280	COG0583	DNA-binding transcription factor activity
PESP_RS04300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PESP_RS04305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PESP_RS04310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PESP_RS04315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PESP_RS04320	COG1968	undecaprenyl-diphosphatase activity
PESP_RS04330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PESP_RS04335	COG0163	prenyltransferase activity
PESP_RS04340	COG1131	(ABC) transporter
PESP_RS04345	COG0842	Transport permease protein
PESP_RS04360	COG0076	glutamate decarboxylase activity
PESP_RS04370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PESP_RS04375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PESP_RS04385	COG0137	argininosuccinate synthase activity
PESP_RS04390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PESP_RS04390	COG0165	Argininosuccinate lyase
PESP_RS04445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PESP_RS04455	COG0301	tRNA thio-modification
PESP_RS04455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PESP_RS04460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PESP_RS04470	COG1666	GTP binding
PESP_RS04480	COG4206	TonB-dependent receptor
PESP_RS04520	COG3267	Type II secretory pathway component ExeA
PESP_RS04520	COG3409	Peptidoglycan-binding domain 1 protein
PESP_RS04535	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PESP_RS04535	COG0506	proline dehydrogenase activity
PESP_RS04535	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PESP_RS04545	COG4991	sh3 domain protein
PESP_RS04550	COG3025	triphosphatase activity
PESP_RS04560	COG0784	Response regulator, receiver
PESP_RS04560	COG2198	Histidine kinase
PESP_RS04560	COG2205	protein histidine kinase activity
PESP_RS04560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS04580	COG0004	ammonium transporteR
PESP_RS04585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PESP_RS04590	COG0840	transmembrane signaling receptor activity
PESP_RS04595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PESP_RS04600	COG0540	Belongs to the ATCase OTCase family
PESP_RS04605	COG1981	membrane
PESP_RS04615	COG0316	Belongs to the HesB IscA family
PESP_RS04630	COG2211	Major facilitator Superfamily
PESP_RS04645	COG2813	Specifically methylates the guanine in position
PESP_RS04655	COG0271	Belongs to the BolA IbaG family
PESP_RS04660	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PESP_RS04665	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PESP_RS04670	COG1805	sodium ion transport
PESP_RS04675	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PESP_RS04680	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PESP_RS04685	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PESP_RS04690	COG2871	sodium ion transport
PESP_RS04695	COG1477	protein flavinylation
PESP_RS04700	COG2991	Protein conserved in bacteria
PESP_RS04710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PESP_RS04730	COG0109	protoheme IX farnesyltransferase activity
PESP_RS04745	COG0123	including yeast histone deacetylase and acetoin utilization protein
PESP_RS04755	COG0488	(ABC) transporter
PESP_RS04760	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PESP_RS04765	COG0646	methionine synthase
PESP_RS04765	COG1410	methionine synthase
PESP_RS04770	COG0646	methionine synthase
PESP_RS04770	COG1410	methionine synthase
PESP_RS04795	COG3237	CsbD-like
PESP_RS04800	COG1643	Atp-dependent helicase
PESP_RS04855	COG1064	alcohol dehydrogenase
PESP_RS04860	COG2814	Major facilitator Superfamily
PESP_RS04895	COG1764	response to oxidative stress
PESP_RS04905	COG0415	Belongs to the DNA photolyase family
PESP_RS04910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PESP_RS04920	COG2205	protein histidine kinase activity
PESP_RS04925	COG0745	RESPONSE REGULATOR receiver
PESP_RS04950	COG5001	Diguanylate cyclase
PESP_RS04955	COG0625	glutathione transferase activity
PESP_RS04965	COG0693	protein deglycase activity
PESP_RS04970	COG0583	DNA-binding transcription factor activity
PESP_RS04990	COG0339	signal peptide processing
PESP_RS05000	COG3264	Mechanosensitive ion channel
PESP_RS05000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PESP_RS05005	COG4771	TonB-dependent receptor
PESP_RS05015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PESP_RS05025	COG0443	Heat shock 70 kDa protein
PESP_RS05030	COG1803	Methylglyoxal synthase
PESP_RS05055	COG0739	heme binding
PESP_RS05060	COG3141	response to X-ray
PESP_RS05075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PESP_RS05080	COG2186	Transcriptional regulator
PESP_RS05085	COG0450	alkyl hydroperoxide reductase
PESP_RS05090	COG4206	TonB-dependent receptor
PESP_RS05095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PESP_RS05100	COG2867	negative regulation of translational initiation
PESP_RS05105	COG2914	Belongs to the UPF0125 (RnfH) family
PESP_RS05110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PESP_RS05115	COG2827	Endonuclease containing a URI domain
PESP_RS05130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PESP_RS05135	COG0583	DNA-binding transcription factor activity
PESP_RS05140	COG3706	GGDEF domain
PESP_RS05155	COG0745	RESPONSE REGULATOR receiver
PESP_RS05160	COG2205	protein histidine kinase activity
PESP_RS05175	COG4326	sporulation control protein
PESP_RS05180	COG2153	protein acetylation
PESP_RS05185	COG0733	neurotransmitter:sodium symporter activity
PESP_RS05190	COG2205	protein histidine kinase activity
PESP_RS05195	COG0745	RESPONSE REGULATOR receiver
PESP_RS05220	COG3385	transposase activity
PESP_RS05225	COG1534	Rna-binding protein
PESP_RS05230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PESP_RS05235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PESP_RS05240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PESP_RS05245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PESP_RS05250	COG0149	triose-phosphate isomerase activity
PESP_RS05255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PESP_RS05350	COG2197	response regulator
PESP_RS05360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PESP_RS05365	COG0564	pseudouridine synthase activity
PESP_RS05375	COG0542	response to heat
PESP_RS05380	COG0840	transmembrane signaling receptor activity
PESP_RS05385	COG2918	glutathione biosynthetic process
PESP_RS05395	COG4536	flavin adenine dinucleotide binding
PESP_RS05400	COG4137	Cytochrome C assembly protein
PESP_RS05405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PESP_RS05410	COG0228	four-way junction DNA binding
PESP_RS05415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PESP_RS05420	COG0336	Belongs to the RNA methyltransferase TrmD family
PESP_RS05425	COG0335	large ribosomal subunit rRNA binding
PESP_RS05430	COG1605	Chorismate mutase
PESP_RS05430	COG0287	Prephenate dehydrogenase
PESP_RS05435	COG1605	Chorismate mutase
PESP_RS05435	COG0077	Prephenate dehydratase
PESP_RS05445	COG0023	Translation Initiation Factor
PESP_RS05465	COG1448	Aminotransferase
PESP_RS05480	COG1595	DNA-templated transcription, initiation
PESP_RS05490	COG2304	oxidoreductase activity
PESP_RS05510	COG0714	Associated with various cellular activities
PESP_RS05515	COG0183	Belongs to the thiolase family
PESP_RS05520	COG1250	3-hydroxyacyl-CoA dehydrogenase
PESP_RS05520	COG1024	Enoyl-CoA hydratase
PESP_RS05530	COG2315	Protein conserved in bacteria
PESP_RS05535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PESP_RS05540	COG3300	MHYT domain
PESP_RS05540	COG5001	Diguanylate cyclase
PESP_RS05545	COG1025	Belongs to the peptidase M16 family
PESP_RS05555	COG0251	oxidation-reduction process
PESP_RS05565	COG2840	Smr protein MutS2
PESP_RS05570	COG2890	protein-(glutamine-N5) methyltransferase activity
PESP_RS05575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PESP_RS05590	COG3101	peptidyl-lysine hydroxylation
PESP_RS05605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PESP_RS05630	COG1335	isochorismatase
PESP_RS05635	COG5002	protein histidine kinase activity
PESP_RS05635	COG2205	protein histidine kinase activity
PESP_RS05635	COG0784	Response regulator, receiver
PESP_RS05645	COG4251	negative regulation of phosphorylation
PESP_RS05645	COG5001	Diguanylate cyclase
PESP_RS05645	COG3706	GGDEF domain
PESP_RS05645	COG2203	Gaf domain
PESP_RS05655	COG2204	response regulator
PESP_RS05670	COG3046	protein related to deoxyribodipyrimidine photolyase
PESP_RS05685	COG0779	Required for maturation of 30S ribosomal subunits
PESP_RS05690	COG0195	Participates in both transcription termination and antitermination
PESP_RS05695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PESP_RS05700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PESP_RS05705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PESP_RS05710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PESP_RS05715	COG1185	polyribonucleotide nucleotidyltransferase activity
PESP_RS05730	COG2111	Na H antiporter
PESP_RS05730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PESP_RS05735	COG1006	Multisubunit Na H antiporter MnhC subunit
PESP_RS05740	COG0651	ATP synthesis coupled electron transport
PESP_RS05745	COG1863	multisubunit Na H antiporter MnhE subunit
PESP_RS05750	COG2212	antiporter activity
PESP_RS05755	COG1320	monovalent cation:proton antiporter activity
PESP_RS05765	COG5002	protein histidine kinase activity
PESP_RS05765	COG5001	Diguanylate cyclase
PESP_RS05770	COG0789	Transcriptional regulator
PESP_RS05775	COG2217	Heavy metal translocating P-type atpase
PESP_RS05830	COG0724	RNA recognition motif
PESP_RS05840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PESP_RS05845	COG0321	lipoyl(octanoyl) transferase activity
PESP_RS05850	COG2921	Belongs to the UPF0250 family
PESP_RS05860	COG1686	Belongs to the peptidase S11 family
PESP_RS05865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PESP_RS05870	COG0772	Belongs to the SEDS family
PESP_RS05875	COG0768	penicillin binding
PESP_RS05880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PESP_RS05885	COG0799	negative regulation of ribosome biogenesis
PESP_RS05890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PESP_RS05900	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
PESP_RS05905	COG0495	leucyl-tRNA aminoacylation
PESP_RS05915	COG1067	ATP-dependent peptidase activity
PESP_RS05920	COG0545	Peptidyl-prolyl cis-trans isomerase
PESP_RS05935	COG0668	transmembrane transport
PESP_RS05945	COG2391	methyltransferase activity
PESP_RS05955	COG0477	Major facilitator Superfamily
PESP_RS06015	COG1404	Belongs to the peptidase S8 family
PESP_RS06055	COG0123	including yeast histone deacetylase and acetoin utilization protein
PESP_RS06070	COG1199	ATP-dependent helicase activity
PESP_RS06075	COG0417	DNA replication proofreading
PESP_RS06100	COG1061	Type III restriction enzyme res subunit
PESP_RS06110	COG0729	surface antigen
PESP_RS06125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PESP_RS06125	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PESP_RS06135	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PESP_RS06165	COG3098	single-species biofilm formation
PESP_RS06170	COG0564	pseudouridine synthase activity
PESP_RS06180	COG0741	lytic transglycosylase activity
PESP_RS06180	COG1388	LysM domain
PESP_RS06185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PESP_RS06190	COG2226	methyltransferase
PESP_RS06195	COG0328	RNA-DNA hybrid ribonuclease activity
PESP_RS06200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PESP_RS06255	COG0121	glutamine amidotransferase
PESP_RS06265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PESP_RS06270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PESP_RS06275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PESP_RS06280	COG2226	methyltransferase
PESP_RS06290	COG1451	nucleotide metabolic process
PESP_RS06295	COG1801	Protein of unknown function DUF72
PESP_RS06300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PESP_RS06340	COG0513	Belongs to the DEAD box helicase family
PESP_RS06365	COG0626	cystathionine gamma-synthase activity
PESP_RS06395	COG1960	acyl-CoA dehydrogenase activity
PESP_RS06405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PESP_RS06410	COG1823	symporter activity
PESP_RS06415	COG2197	response regulator
PESP_RS06420	COG0322	excinuclease ABC activity
PESP_RS06470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PESP_RS06475	COG3385	transposase activity
PESP_RS06480	COG1115	amino acid carrier protein
PESP_RS06510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PESP_RS06515	COG0072	phenylalanine-tRNA ligase activity
PESP_RS06520	COG0776	regulation of translation
PESP_RS06535	COG2866	Carboxypeptidase
PESP_RS06540	COG1115	amino acid carrier protein
PESP_RS06550	COG3139	Protein of unknown function (DUF1315)
PESP_RS06595	COG0210	DNA helicase
PESP_RS06605	COG2326	polyphosphate kinase activity
PESP_RS06630	COG2755	lipolytic protein G-D-S-L family
PESP_RS06635	COG4181	ATPase activity
PESP_RS06640	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PESP_RS06645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PESP_RS06650	COG0632	four-way junction helicase activity
PESP_RS06655	COG2255	four-way junction helicase activity
PESP_RS06660	COG3293	Transposase
PESP_RS06670	COG0811	peptide transport
PESP_RS06675	COG0848	biopolymer transport protein
PESP_RS06685	COG0823	Involved in the tonB-independent uptake of proteins
PESP_RS06690	COG2885	chlorophyll binding
PESP_RS06695	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PESP_RS06740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PESP_RS06750	COG5002	protein histidine kinase activity
PESP_RS06750	COG0784	Response regulator, receiver
PESP_RS06780	COG2828	Protein conserved in bacteria
PESP_RS06825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PESP_RS06830	COG1074	ATP-dependent DNA helicase activity
PESP_RS06835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PESP_RS06850	COG0037	tRNA processing
PESP_RS06860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PESP_RS06875	COG2217	Heavy metal translocating P-type atpase
PESP_RS06885	COG2010	Cytochrome c
PESP_RS06900	COG3278	Belongs to the heme-copper respiratory oxidase family
PESP_RS06930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PESP_RS06935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PESP_RS06940	COG2957	Belongs to the agmatine deiminase family
PESP_RS06960	COG0583	DNA-binding transcription factor activity
PESP_RS06985	COG0848	biopolymer transport protein
PESP_RS07000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PESP_RS07010	COG3083	sulfuric ester hydrolase activity
PESP_RS07015	COG3082	Protein of unknown function (DUF1414)
PESP_RS07020	COG3081	Nucleoid-associated protein
PESP_RS07025	COG1530	ribonuclease E activity
PESP_RS07040	COG0424	maF-like protein
PESP_RS07045	COG1399	metal-binding, possibly nucleic acid-binding protein
PESP_RS07050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PESP_RS07055	COG0416	fatty acid biosynthetic process
PESP_RS07060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PESP_RS07070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PESP_RS07075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PESP_RS07080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PESP_RS07085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PESP_RS07090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PESP_RS07095	COG0470	DNA polymerase III
PESP_RS07105	COG0084	hydrolase, TatD family'
PESP_RS07115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PESP_RS07115	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PESP_RS07125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PESP_RS07130	COG0372	Belongs to the citrate synthase family
PESP_RS07135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PESP_RS07140	COG2828	Protein conserved in bacteria
PESP_RS07180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PESP_RS07185	COG2223	nitrite transmembrane transporter activity
PESP_RS07190	COG0515	serine threonine protein kinase
PESP_RS07190	COG2815	serine threonine protein kinase
PESP_RS07200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PESP_RS07205	COG0243	molybdopterin cofactor binding
PESP_RS07215	COG0746	molybdenum cofactor guanylyltransferase activity
PESP_RS07220	COG0521	Mo-molybdopterin cofactor biosynthetic process
PESP_RS07225	COG0315	cyclic pyranopterin monophosphate synthase activity
PESP_RS07230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PESP_RS07235	COG0314	molybdopterin synthase activity
PESP_RS07245	COG2258	MOSC domain
PESP_RS07250	COG0583	DNA-binding transcription factor activity
PESP_RS07270	COG2146	nitrite reductase [NAD(P)H] activity
PESP_RS07275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PESP_RS07275	COG2146	nitrite reductase [NAD(P)H] activity
PESP_RS07280	COG0800	Aldolase
PESP_RS07285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PESP_RS07285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PESP_RS07290	COG0489	protein tyrosine kinase activity
PESP_RS07295	COG0717	Belongs to the dCTP deaminase family
PESP_RS07315	COG0436	Aminotransferase
PESP_RS07325	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
PESP_RS07345	COG1876	peptidase activity
PESP_RS07350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PESP_RS07355	COG1393	Belongs to the ArsC family
PESP_RS07370	COG0857	belongs to the CobB CobQ family
PESP_RS07370	COG0280	phosphate acetyltransferase
PESP_RS07375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PESP_RS07380	COG3092	negative regulation of chromosome organization
PESP_RS07385	COG2226	methyltransferase
PESP_RS07410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PESP_RS07415	COG1187	pseudouridine synthase activity
PESP_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS07425	COG2267	carboxylic ester hydrolase activity
PESP_RS07430	COG0616	signal peptide processing
PESP_RS07435	COG1301	dicarboxylic acid transport
PESP_RS07455	COG2862	Uncharacterized protein family, UPF0114
PESP_RS07460	COG0366	Alpha amylase catalytic
PESP_RS07480	COG0366	Alpha amylase catalytic
PESP_RS07500	COG1609	Transcriptional regulator
PESP_RS07505	COG0837	glucose binding
PESP_RS07510	COG1609	Transcriptional regulator
PESP_RS07525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PESP_RS07535	COG0217	transcriptional regulatory protein
PESP_RS07540	COG5265	(ABC) transporter
PESP_RS07550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PESP_RS07555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PESP_RS07560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PESP_RS07575	COG2824	Alkylphosphonate utilization operon protein PhnA
PESP_RS07580	COG0189	ligase activity
PESP_RS07585	COG1214	PFAM Peptidase M22, glycoprotease
PESP_RS07585	COG0456	acetyltransferase
PESP_RS07590	COG1285	pathogenesis
PESP_RS07595	COG3300	MHYT domain
PESP_RS07595	COG5001	Diguanylate cyclase
PESP_RS07620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PESP_RS07625	COG0270	DNA (cytosine-5-)-methyltransferase activity
PESP_RS07910	COG1285	pathogenesis
PESP_RS07935	COG0583	DNA-binding transcription factor activity
PESP_RS07940	COG4591	ABC-type transport system involved in lipoprotein release permease component
PESP_RS07945	COG1136	(ABC) transporter
PESP_RS07950	COG4591	ABC-type transport system involved in lipoprotein release permease component
PESP_RS07960	COG0318	PFAM AMP-dependent synthetase and ligase
PESP_RS07975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PESP_RS07980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PESP_RS07985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PESP_RS08000	COG1522	sequence-specific DNA binding
PESP_RS08005	COG0659	secondary active sulfate transmembrane transporter activity
PESP_RS08010	COG3275	phosphorelay sensor kinase activity
PESP_RS08015	COG3279	Response regulator of the LytR AlgR family
PESP_RS08020	COG0469	pyruvate kinase activity
PESP_RS08025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PESP_RS08030	COG0252	asparaginase activity
PESP_RS08035	COG0616	signal peptide processing
PESP_RS08040	COG0446	pyridine nucleotide-disulphide oxidoreductase
PESP_RS08040	COG1902	pentaerythritol trinitrate reductase activity
PESP_RS08050	COG0778	Nitroreductase
PESP_RS08070	COG0545	Peptidyl-prolyl cis-trans isomerase
PESP_RS08095	COG3738	Protein conserved in bacteria
PESP_RS08110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PESP_RS08120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PESP_RS08130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PESP_RS08135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PESP_RS08140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PESP_RS08145	COG0539	negative regulation of cytoplasmic translation
PESP_RS08150	COG0776	regulation of translation
PESP_RS08160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PESP_RS08165	COG0284	orotidine-5'-phosphate decarboxylase activity
PESP_RS08180	COG0513	Belongs to the DEAD box helicase family
PESP_RS08185	COG1054	Belongs to the UPF0176 family
PESP_RS08195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PESP_RS08205	COG2176	DNA-directed DNA polymerase activity
PESP_RS08210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PESP_RS08215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PESP_RS08220	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PESP_RS08230	COG0367	asparagine synthase
PESP_RS08235	COG1984	allophanate hydrolase subunit 2
PESP_RS08240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PESP_RS08245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PESP_RS08245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PESP_RS08255	COG0583	DNA-binding transcription factor activity
PESP_RS08260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PESP_RS08265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PESP_RS08275	COG4770	biotin carboxylase activity
PESP_RS08285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PESP_RS08290	COG1960	acyl-CoA dehydrogenase activity
PESP_RS08300	COG0183	Belongs to the thiolase family
PESP_RS08315	COG1024	Enoyl-CoA hydratase
PESP_RS08320	COG1024	Enoyl-CoA hydratase
PESP_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS08370	COG0183	Belongs to the thiolase family
PESP_RS08415	COG1914	H( )-stimulated, divalent metal cation uptake system
PESP_RS08465	COG4628	conserved protein (DUF2132)
PESP_RS08470	COG0604	alcohol dehydrogenase
PESP_RS08475	COG1309	transcriptional regulator
PESP_RS08480	COG3130	regulation of translation
PESP_RS08485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PESP_RS08500	COG1607	acyl-coa hydrolase
PESP_RS08505	COG2056	Na+-H+ antiporter family
PESP_RS08520	COG0714	Associated with various cellular activities
PESP_RS08525	COG2201	protein-glutamate methylesterase activity
PESP_RS08570	COG0745	RESPONSE REGULATOR receiver
PESP_RS08640	COG0281	malic enzyme
PESP_RS08645	COG0405	Gamma-glutamyltransferase
PESP_RS08665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PESP_RS08670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PESP_RS08675	COG0488	(ABC) transporter
PESP_RS08690	COG2814	Major facilitator Superfamily
PESP_RS08725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PESP_RS08760	COG1131	(ABC) transporter
PESP_RS08775	COG5001	Diguanylate cyclase
PESP_RS08775	COG3300	MHYT domain
PESP_RS08795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PESP_RS08805	COG1278	Cold shock
PESP_RS08810	COG0701	Predicted permease
PESP_RS08820	COG2860	membrane
PESP_RS08840	COG0501	Belongs to the peptidase M48B family
PESP_RS08850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PESP_RS08855	COG2226	methyltransferase
PESP_RS08860	COG0156	8-amino-7-oxononanoate synthase activity
PESP_RS08865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PESP_RS08870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PESP_RS08885	COG1178	ABC-type Fe3 transport system permease component
PESP_RS08890	COG3842	ATPase activity
PESP_RS08900	COG0017	Asparaginyl-tRNA synthetase
PESP_RS08935	COG1720	tRNA m6t6A37 methyltransferase activity
PESP_RS08940	COG0442	prolyl-tRNA aminoacylation
PESP_RS08950	COG5002	protein histidine kinase activity
PESP_RS08950	COG2205	protein histidine kinase activity
PESP_RS08950	COG0784	Response regulator, receiver
PESP_RS08955	COG1668	transmembrane transport
PESP_RS08960	COG4555	ABC transporter
PESP_RS08980	COG3385	transposase activity
PESP_RS08985	COG3152	Membrane
PESP_RS08995	COG0022	dehydrogenase e1 component
PESP_RS09005	COG2988	succinylglutamate desuccinylase activity
PESP_RS09010	COG0033	Phosphoglucomutase
PESP_RS09015	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PESP_RS09020	COG0596	Alpha beta hydrolase
PESP_RS09040	COG0735	belongs to the Fur family
PESP_RS09045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PESP_RS09055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PESP_RS09060	COG0045	succinate-CoA ligase (ADP-forming) activity
PESP_RS09065	COG0508	dehydrogenase complex catalyzes the overall conversion of
PESP_RS09070	COG0567	Dehydrogenase, E1 component
PESP_RS09080	COG1053	succinate dehydrogenase
PESP_RS09085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PESP_RS09105	COG2166	iron-sulfur cluster assembly
PESP_RS09110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PESP_RS09115	COG0564	pseudouridine synthase activity
PESP_RS09120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PESP_RS09125	COG2835	tetraacyldisaccharide 4'-kinase activity
PESP_RS09130	COG1663	tetraacyldisaccharide 4'-kinase activity
PESP_RS09135	COG1132	(ABC) transporter
PESP_RS09140	COG0658	competence protein
PESP_RS09140	COG2333	competence protein COMEC
PESP_RS09155	COG0488	(ABC) transporter
PESP_RS09165	COG0116	Belongs to the methyltransferase superfamily
PESP_RS09165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PESP_RS09175	COG0167	dihydroorotate dehydrogenase activity
PESP_RS09180	COG2902	Dehydrogenase
PESP_RS09210	COG0308	aminopeptidase N
PESP_RS09215	COG1757	Na H antiporter
PESP_RS09225	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PESP_RS09235	COG1956	GAF domain-containing protein
PESP_RS09265	COG0670	Belongs to the BI1 family
PESP_RS09275	COG2923	Belongs to the DsrF TusC family
PESP_RS09285	COG2920	part of a sulfur-relay system
PESP_RS09290	COG1187	pseudouridine synthase activity
PESP_RS09295	COG2816	NAD+ diphosphatase activity
PESP_RS09310	COG0482	sulfurtransferase activity
PESP_RS09315	COG2915	High frequency lysogenization protein hflD homolog
PESP_RS09320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PESP_RS09325	COG2850	peptidyl-arginine hydroxylation
PESP_RS09340	COG2234	aminopeptidase activity
PESP_RS09360	COG1132	(ABC) transporter
PESP_RS09375	COG3977	Valine--pyruvate aminotransferase
PESP_RS09385	COG2133	pyrroloquinoline quinone binding
PESP_RS09400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PESP_RS09405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PESP_RS09410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PESP_RS09415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PESP_RS09420	COG1674	ftsk spoiiie
PESP_RS09420	COG0531	amino acid
PESP_RS09430	COG0686	Belongs to the AlaDH PNT family
PESP_RS09435	COG3385	transposase activity
PESP_RS09440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PESP_RS09445	COG0492	ferredoxin-NADP+ reductase activity
PESP_RS09450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PESP_RS09455	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PESP_RS09460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PESP_RS09465	COG0542	response to heat
PESP_RS09470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PESP_RS09475	COG1278	Cold shock
PESP_RS09490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PESP_RS09510	COG3001	Fructosamine kinase
PESP_RS09520	COG0307	riboflavin synthase, alpha
PESP_RS09525	COG0534	Mate efflux family protein
PESP_RS09545	COG3291	Pkd domain containing protein
PESP_RS09550	COG1472	Belongs to the glycosyl hydrolase 3 family
PESP_RS09570	COG1472	Belongs to the glycosyl hydrolase 3 family
PESP_RS09575	COG0477	Major facilitator Superfamily
PESP_RS09580	COG0745	RESPONSE REGULATOR receiver
PESP_RS09585	COG2205	protein histidine kinase activity
PESP_RS09590	COG0569	domain protein
PESP_RS09595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PESP_RS09600	COG0477	Major facilitator Superfamily
PESP_RS09605	COG1609	Transcriptional regulator
PESP_RS09610	COG3507	Belongs to the glycosyl hydrolase 43 family
PESP_RS09620	COG1070	Carbohydrate kinase
PESP_RS09625	COG2115	Belongs to the xylose isomerase family
PESP_RS09630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PESP_RS09635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PESP_RS09640	COG2017	converts alpha-aldose to the beta-anomer
PESP_RS09660	COG0210	DNA helicase
PESP_RS09715	COG4771	TonB-dependent receptor
PESP_RS09725	COG2211	Major facilitator Superfamily
PESP_RS09800	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PESP_RS09810	COG1247	-acetyltransferase
PESP_RS09845	COG2353	YceI-like domain
PESP_RS09850	COG3038	cytochrome b561
PESP_RS09860	COG0009	L-threonylcarbamoyladenylate synthase
PESP_RS09865	COG0613	PHP domain protein
PESP_RS09870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PESP_RS09875	COG0512	Glutamine amidotransferase of anthranilate synthase
PESP_RS09880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PESP_RS09885	COG0134	indole-3-glycerol-phosphate synthase activity
PESP_RS09885	COG0135	phosphoribosylanthranilate isomerase activity
PESP_RS09900	COG0693	protein deglycase activity
PESP_RS09905	COG0776	regulation of translation
PESP_RS09910	COG2917	probably involved in intracellular septation
PESP_RS09920	COG0733	neurotransmitter:sodium symporter activity
PESP_RS09925	COG2350	Protein conserved in bacteria
PESP_RS09950	COG0628	permease
PESP_RS09955	COG1090	epimerase
PESP_RS09960	COG2199	diguanylate cyclase activity
PESP_RS09965	COG1472	Belongs to the glycosyl hydrolase 3 family
PESP_RS09980	COG2211	Major facilitator Superfamily
PESP_RS10000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PESP_RS10005	COG1505	serine-type exopeptidase activity
PESP_RS10030	COG0633	Ferredoxin
PESP_RS10030	COG0543	2 iron, 2 sulfur cluster binding
PESP_RS10035	COG2133	pyrroloquinoline quinone binding
PESP_RS10115	COG1472	Belongs to the glycosyl hydrolase 3 family
PESP_RS10125	COG2211	Major facilitator Superfamily
PESP_RS10135	COG4251	negative regulation of phosphorylation
PESP_RS10140	COG3300	MHYT domain
PESP_RS10140	COG5001	Diguanylate cyclase
PESP_RS10150	COG5002	protein histidine kinase activity
PESP_RS10200	COG2925	Exonuclease
PESP_RS10210	COG2084	Dehydrogenase
PESP_RS10215	COG0386	Belongs to the glutathione peroxidase family
PESP_RS10220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PESP_RS10225	COG0733	neurotransmitter:sodium symporter activity
PESP_RS10235	COG0527	aspartate kinase activity
PESP_RS10240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PESP_RS10265	COG3547	Transposase (IS116 IS110 IS902 family)
PESP_RS10285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PESP_RS10295	COG0659	secondary active sulfate transmembrane transporter activity
PESP_RS10315	COG0604	alcohol dehydrogenase
PESP_RS10345	COG2999	glutathione oxidoreductase activity
PESP_RS10360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PESP_RS10375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PESP_RS10380	COG0505	Belongs to the CarA family
PESP_RS10385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PESP_RS10410	COG2814	Major facilitator Superfamily
PESP_RS10415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PESP_RS10420	COG1420	regulation of RNA biosynthetic process
PESP_RS10425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PESP_RS10435	COG0497	DNA recombination
PESP_RS10445	COG2199	diguanylate cyclase activity
PESP_RS10445	COG2203	Gaf domain
PESP_RS10455	COG0493	'glutamate synthase
PESP_RS10460	COG0070	glutamate synthase
PESP_RS10460	COG0067	glutamate synthase
PESP_RS10460	COG0069	glutamate synthase activity
PESP_RS10470	COG1136	(ABC) transporter
PESP_RS10480	COG0577	efflux transmembrane transporter activity
PESP_RS10480	COG1136	(ABC) transporter
PESP_RS10485	COG2204	response regulator
PESP_RS10490	COG5000	phosphorelay sensor kinase activity
PESP_RS10495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PESP_RS10500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PESP_RS10505	COG2766	serine protein kinase
PESP_RS10510	COG2718	Belongs to the UPF0229 family
PESP_RS10515	COG2719	SpoVR family
PESP_RS10525	COG2201	protein-glutamate methylesterase activity
PESP_RS10530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PESP_RS10535	COG0563	adenylate kinase activity
PESP_RS10540	COG0326	Molecular chaperone. Has ATPase activity
PESP_RS10545	COG0477	Major facilitator Superfamily
PESP_RS10550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PESP_RS10555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PESP_RS10565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PESP_RS10570	COG3219	Protein conserved in bacteria
PESP_RS10575	COG3220	belongs to the UPF0276 family
PESP_RS10585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PESP_RS10610	COG0848	biopolymer transport protein
PESP_RS10615	COG0811	peptide transport
PESP_RS10620	COG0811	peptide transport
PESP_RS10630	COG1278	Cold shock
PESP_RS10635	COG0418	dihydroorotase activity
PESP_RS10640	COG2203	Gaf domain
PESP_RS10640	COG3706	GGDEF domain
PESP_RS10640	COG4251	negative regulation of phosphorylation
PESP_RS10640	COG5001	Diguanylate cyclase
PESP_RS10645	COG0583	DNA-binding transcription factor activity
PESP_RS10650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PESP_RS10655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PESP_RS10680	COG3228	Belongs to the MtfA family
PESP_RS10705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PESP_RS10710	COG0494	nUDIX hydrolase
PESP_RS10715	COG1760	l-serine dehydratase
PESP_RS10730	COG2252	PERMEase
PESP_RS10745	COG3012	SEC-C Motif Domain Protein
PESP_RS10775	COG2198	Histidine kinase
PESP_RS10775	COG2205	protein histidine kinase activity
PESP_RS10775	COG0784	Response regulator, receiver
PESP_RS10780	COG3437	response regulator, receiver
PESP_RS10790	COG1418	mRNA catabolic process
PESP_RS10795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PESP_RS10810	COG1643	Atp-dependent helicase
PESP_RS10825	COG0363	glucosamine-6-phosphate deaminase activity
PESP_RS10830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PESP_RS10835	COG0166	Belongs to the GPI family
PESP_RS10840	COG1104	cysteine desulfurase activity
PESP_RS10860	COG4783	chaperone-mediated protein folding
PESP_RS10865	COG1393	Belongs to the ArsC family
PESP_RS10885	COG2854	intermembrane phospholipid transfer
PESP_RS10895	COG3314	Sporulation integral membrane protein YlbJ
PESP_RS10905	COG2716	regulation of RNA biosynthetic process
PESP_RS10910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PESP_RS10935	COG0602	queuosine metabolic process
PESP_RS10940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PESP_RS10965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PESP_RS10970	COG0556	nucleotide-excision repair
PESP_RS10975	COG0534	Mate efflux family protein
PESP_RS11000	COG2200	EAL domain
PESP_RS11000	COG2771	luxR family
PESP_RS11005	COG4657	Part of a membrane complex involved in electron transport
PESP_RS11010	COG2878	Part of a membrane complex involved in electron transport
PESP_RS11020	COG4658	electron transport chain
PESP_RS11025	COG4659	FMN binding
PESP_RS11030	COG4660	Part of a membrane complex involved in electron transport
PESP_RS11035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PESP_RS11070	COG3708	Transcriptional regulator
PESP_RS11070	COG2207	Transcriptional regulator
PESP_RS11090	COG3385	transposase activity
PESP_RS11115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PESP_RS11125	COG0800	Aldolase
PESP_RS11130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PESP_RS11135	COG2271	Major facilitator Superfamily
PESP_RS11140	COG1917	Cupin 2, conserved barrel domain protein
PESP_RS11160	COG0346	lactoylglutathione lyase activity
PESP_RS11165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PESP_RS11240	COG0745	RESPONSE REGULATOR receiver
PESP_RS11245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PESP_RS11265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PESP_RS11270	COG3115	cell septum assembly
PESP_RS11275	COG1196	nuclear chromosome segregation
PESP_RS11280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PESP_RS11285	COG4269	membrane
PESP_RS11300	COG1166	arginine decarboxylase activity
PESP_RS11315	COG1742	UPF0060 membrane protein
PESP_RS11325	COG1214	PFAM Peptidase M22, glycoprotease
PESP_RS11325	COG0456	acetyltransferase
PESP_RS11335	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PESP_RS11350	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PESP_RS11355	COG2363	Small membrane protein
PESP_RS11365	COG0583	DNA-binding transcription factor activity
PESP_RS11370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PESP_RS11375	COG5505	Protein of unknown function (DUF819)
PESP_RS11390	COG3437	response regulator, receiver
PESP_RS11390	COG0784	Response regulator, receiver
PESP_RS11395	COG2890	protein-(glutamine-N5) methyltransferase activity
PESP_RS11400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PESP_RS11405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PESP_RS11410	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PESP_RS11415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PESP_RS11420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PESP_RS11425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PESP_RS11430	COG0193	aminoacyl-tRNA hydrolase activity
PESP_RS11435	COG0012	GTP binding
PESP_RS11500	COG5001	Diguanylate cyclase
PESP_RS11500	COG3300	MHYT domain
PESP_RS11505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PESP_RS11510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PESP_RS11515	COG1702	phosphate starvation-inducible protein PhoH
PESP_RS11520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PESP_RS11525	COG4535	Mg2 and Co2 transporter CorC
PESP_RS11530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PESP_RS11550	COG1902	pentaerythritol trinitrate reductase activity
PESP_RS11555	COG0523	cobalamin synthesis protein
PESP_RS11565	COG4221	oxidoreductase activity
PESP_RS11575	COG2205	protein histidine kinase activity
PESP_RS11575	COG0784	Response regulator, receiver
PESP_RS11620	COG0037	tRNA processing
PESP_RS11625	COG0825	malonyl-CoA metabolic process
PESP_RS11630	COG0587	DNA-directed DNA polymerase activity
PESP_RS11635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PESP_RS11640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PESP_RS11650	COG1294	oxidase, subunit
PESP_RS11655	COG4890	Cyd operon protein YbgT
PESP_RS11660	COG4988	ABC transporter
PESP_RS11665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PESP_RS11670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PESP_RS11675	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PESP_RS11680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PESP_RS11685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PESP_RS11700	COG0750	zinc metalloprotease
PESP_RS11705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PESP_RS11710	COG0575	Belongs to the CDS family
PESP_RS11715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PESP_RS11720	COG0233	cytoplasmic translational termination
PESP_RS11725	COG0528	UMP kinase activity
PESP_RS11730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PESP_RS11735	COG0052	Belongs to the universal ribosomal protein uS2 family
PESP_RS11740	COG0024	Methionine aminopeptidase
PESP_RS11745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PESP_RS11750	COG2171	N-acyltransferase activity
PESP_RS11760	COG2154	pterin-4-alpha-carbinolamine dehydratase
PESP_RS11770	COG0626	cystathionine gamma-synthase activity
PESP_RS11775	COG3768	UPF0283 membrane protein
PESP_RS11780	COG3106	COG3106 Predicted ATPase
PESP_RS11785	COG1983	PspC domain protein
PESP_RS11795	COG1842	Phage shock protein A
PESP_RS11800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PESP_RS11805	COG0747	negative chemotaxis
PESP_RS11815	COG4171	peptide transport system, permease
PESP_RS11825	COG4172	Belongs to the ABC transporter superfamily
PESP_RS11830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PESP_RS11835	COG0776	regulation of translation
PESP_RS11840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PESP_RS11845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PESP_RS11850	COG0740	serine-type endopeptidase activity
PESP_RS11855	COG0544	peptidyl-prolyl cis-trans isomerase activity
PESP_RS11885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PESP_RS11890	COG0215	cysteine-tRNA ligase activity
PESP_RS11895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PESP_RS11920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PESP_RS11925	COG1286	toxin biosynthetic process
PESP_RS11935	COG0285	dihydrofolate synthase activity
PESP_RS11940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PESP_RS11945	COG0101	tRNA pseudouridine synthase activity
PESP_RS11960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PESP_RS11965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PESP_RS11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PESP_RS11970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PESP_RS11980	COG0702	epimerase
PESP_RS12005	COG2885	chlorophyll binding
PESP_RS12015	COG0814	amino acid
PESP_RS12080	COG0745	RESPONSE REGULATOR receiver
PESP_RS12080	COG2972	Histidine kinase
PESP_RS12085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PESP_RS12090	COG1047	Peptidyl-prolyl cis-trans
PESP_RS12095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PESP_RS12100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PESP_RS12105	COG0196	riboflavin kinase activity
PESP_RS12110	COG0728	peptidoglycan biosynthetic process
PESP_RS12115	COG0268	Binds directly to 16S ribosomal RNA
PESP_RS12120	COG2201	protein-glutamate methylesterase activity
PESP_RS12155	COG3047	cAMP biosynthetic process
PESP_RS12175	COG2194	sulfuric ester hydrolase activity
PESP_RS12195	COG1215	transferase activity, transferring glycosyl groups
PESP_RS12205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PESP_RS12210	COG0457	Tetratricopeptide repeat
PESP_RS12230	COG0179	Fumarylacetoacetate (FAA) hydrolase
PESP_RS12235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PESP_RS12240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PESP_RS12245	COG2853	Lipoprotein
PESP_RS12265	COG1138	Cytochrome C-type biogenesis protein
PESP_RS12270	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PESP_RS12275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PESP_RS12280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PESP_RS12285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PESP_RS12290	COG4133	protoheme IX ABC transporter activity
PESP_RS12310	COG0835	chemotaxis
PESP_RS12320	COG1192	Involved in chromosome partitioning
PESP_RS12325	COG1360	Flagellar Motor Protein
PESP_RS12330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PESP_RS12335	COG2201	protein-glutamate methylesterase activity
PESP_RS12340	COG0643	Histidine kinase
PESP_RS12340	COG0784	Response regulator, receiver
PESP_RS12340	COG2198	Histidine kinase
PESP_RS12345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PESP_RS12370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PESP_RS12385	COG1987	bacterial-type flagellum assembly
PESP_RS12395	COG3190	flagellar
PESP_RS12410	COG1580	Controls the rotational direction of flagella during chemotaxis
PESP_RS12415	COG3144	bacterial-type flagellum assembly
PESP_RS12435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PESP_RS12445	COG1677	Flagellar hook-basal body complex protein FliE
PESP_RS12460	COG0519	Catalyzes the synthesis of GMP from XMP
PESP_RS12480	COG1086	Polysaccharide biosynthesis protein
PESP_RS12485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PESP_RS12500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PESP_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS12520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PESP_RS12525	COG2089	acid synthase
PESP_RS12550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PESP_RS12555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PESP_RS12580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PESP_RS12590	COG0562	UDP-galactopyranose mutase
PESP_RS12595	COG1215	transferase activity, transferring glycosyl groups
PESP_RS12610	COG1516	flagellar protein fliS
PESP_RS12625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PESP_RS12630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PESP_RS12635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PESP_RS12650	COG3951	Flagellar rod assembly protein muramidase FlgJ
PESP_RS12650	COG1705	Flagellar rod assembly protein muramidase FlgJ
PESP_RS12655	COG1706	bacterial-type flagellum-dependent cell motility
PESP_RS12660	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PESP_RS12665	COG4786	Flagellar basal body rod
PESP_RS12670	COG4786	Flagellar basal body rod
PESP_RS12690	COG1815	bacterial-type flagellum-dependent cell motility
PESP_RS12695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PESP_RS12700	COG0835	chemotaxis
PESP_RS12700	COG0784	Response regulator, receiver
PESP_RS12750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PESP_RS12755	COG2197	response regulator
PESP_RS12760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PESP_RS12785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PESP_RS12785	COG0678	peroxiredoxin activity
PESP_RS12845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PESP_RS12850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PESP_RS12855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PESP_RS12860	COG0730	response to heat
PESP_RS12870	COG1051	belongs to the nudix hydrolase family
PESP_RS12875	COG3066	DNA modification
PESP_RS12880	COG0148	phosphopyruvate hydratase activity
PESP_RS12885	COG0504	CTP synthase activity
PESP_RS12890	COG3956	TIGRFAM MazG family protein
PESP_RS12895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PESP_RS12900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PESP_RS12905	COG3437	response regulator, receiver
PESP_RS12905	COG3850	Histidine kinase
PESP_RS12905	COG4999	Histidine kinase
PESP_RS12905	COG2205	protein histidine kinase activity
PESP_RS12910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PESP_RS12915	COG1381	Involved in DNA repair and RecF pathway recombination
PESP_RS12925	COG0571	ribonuclease III activity
PESP_RS12935	COG0481	GTPase activity
PESP_RS12945	COG3026	antisigma factor binding
PESP_RS12955	COG1595	DNA-templated transcription, initiation
PESP_RS12960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PESP_RS12970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PESP_RS12980	COG1047	Peptidyl-prolyl cis-trans
PESP_RS12995	COG3099	Belongs to the UPF0263 family
PESP_RS13000	COG1024	Enoyl-CoA hydratase
PESP_RS13000	COG1250	3-hydroxyacyl-CoA dehydrogenase
PESP_RS13010	COG1346	cytolysis
PESP_RS13015	COG0668	transmembrane transport
PESP_RS13025	COG2319	Wd-40 repeat
PESP_RS13025	COG4249	Peptidase C14 caspase catalytic subunit p20
PESP_RS13035	COG3706	GGDEF domain
PESP_RS13035	COG5001	Diguanylate cyclase
PESP_RS13035	COG4251	negative regulation of phosphorylation
PESP_RS13035	COG2203	Gaf domain
PESP_RS13040	COG2239	Acts as a magnesium transporter
PESP_RS13085	COG0438	transferase activity, transferring glycosyl groups
PESP_RS13120	COG0788	formyltetrahydrofolate deformylase activity
PESP_RS13125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PESP_RS13135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PESP_RS13145	COG4773	Receptor
PESP_RS13160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PESP_RS13180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PESP_RS13185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PESP_RS13190	COG0585	pseudouridine synthase activity
PESP_RS13195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PESP_RS13200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PESP_RS13205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PESP_RS13225	COG3283	Transcriptional regulator of aromatic amino acids metabolism
PESP_RS13250	COG0454	-acetyltransferase
PESP_RS13265	COG3123	guanosine phosphorylase activity
PESP_RS13270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PESP_RS13275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PESP_RS13285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PESP_RS13290	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PESP_RS13295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PESP_RS13315	COG0560	Phosphoserine phosphatase
PESP_RS13325	COG0084	hydrolase, TatD family'
PESP_RS13330	COG0259	pyridoxamine-phosphate oxidase activity
PESP_RS13335	COG0018	arginyl-trna synthetase
PESP_RS13340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PESP_RS13365	COG2205	protein histidine kinase activity
PESP_RS13365	COG0784	Response regulator, receiver
PESP_RS13370	COG0456	acetyltransferase
PESP_RS13385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PESP_RS13390	COG0519	Catalyzes the synthesis of GMP from XMP
PESP_RS13390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PESP_RS13395	COG0516	GMP reductase activity
PESP_RS13395	COG0517	IMP dehydrogenase activity
PESP_RS13400	COG1570	exodeoxyribonuclease VII activity
PESP_RS13410	COG1045	serine acetyltransferase
PESP_RS13415	COG3706	GGDEF domain
PESP_RS13415	COG2203	Gaf domain
PESP_RS13415	COG4251	negative regulation of phosphorylation
PESP_RS13415	COG5001	Diguanylate cyclase
PESP_RS13430	COG0612	Peptidase, M16
PESP_RS13445	COG2199	diguanylate cyclase activity
PESP_RS13445	COG2203	Gaf domain
PESP_RS13450	COG0513	Belongs to the DEAD box helicase family
PESP_RS13470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PESP_RS13480	COG3706	GGDEF domain
PESP_RS13485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PESP_RS13490	COG0697	spore germination
PESP_RS13510	COG0745	RESPONSE REGULATOR receiver
PESP_RS13515	COG0642	Histidine kinase
PESP_RS13520	COG0617	tRNA 3'-terminal CCA addition
PESP_RS13535	COG2204	response regulator
PESP_RS13545	COG2205	protein histidine kinase activity
PESP_RS13570	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PESP_RS13595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PESP_RS13600	COG1489	DNA binding
PESP_RS13620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PESP_RS13625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PESP_RS13630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PESP_RS13645	COG5002	protein histidine kinase activity
PESP_RS13650	COG0745	RESPONSE REGULATOR receiver
PESP_RS13660	COG0126	phosphoglycerate kinase activity
PESP_RS13665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PESP_RS13675	COG2205	protein histidine kinase activity
PESP_RS13690	COG0318	PFAM AMP-dependent synthetase and ligase
PESP_RS13740	COG0517	IMP dehydrogenase activity
PESP_RS13740	COG0516	GMP reductase activity
PESP_RS13745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PESP_RS13755	COG0784	Response regulator, receiver
PESP_RS13755	COG2205	protein histidine kinase activity
PESP_RS13770	COG3706	GGDEF domain
PESP_RS13820	COG3250	beta-galactosidase activity
PESP_RS13825	COG2259	Doxx family
PESP_RS13830	COG2199	diguanylate cyclase activity
PESP_RS13830	COG2203	Gaf domain
PESP_RS13885	COG0596	Alpha beta hydrolase
PESP_RS13905	COG0840	transmembrane signaling receptor activity
PESP_RS13920	COG2205	protein histidine kinase activity
PESP_RS13925	COG0745	RESPONSE REGULATOR receiver
PESP_RS13930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PESP_RS13935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PESP_RS13955	COG4771	TonB-dependent receptor
PESP_RS13960	COG1858	cytochrome C peroxidase
PESP_RS13965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PESP_RS13970	COG0534	Mate efflux family protein
PESP_RS13975	COG0583	DNA-binding transcription factor activity
PESP_RS13990	COG2249	NAD(P)H dehydrogenase (quinone) activity
PESP_RS13995	COG1024	Enoyl-CoA hydratase
PESP_RS14020	COG1879	ABC-type sugar transport system periplasmic component
PESP_RS14025	COG3791	Glutathione-dependent formaldehyde-activating
PESP_RS14030	COG0753	catalase activity
PESP_RS14035	COG0668	transmembrane transport
PESP_RS14050	COG0783	Belongs to the Dps family
PESP_RS14065	COG0625	glutathione transferase activity
PESP_RS14085	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
PESP_RS14150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PESP_RS14150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PESP_RS14155	COG0509	glycine decarboxylation via glycine cleavage system
PESP_RS14160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PESP_RS14170	COG0583	DNA-binding transcription factor activity
PESP_RS14175	COG4774	siderophore transport
PESP_RS14180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PESP_RS14185	COG0557	exoribonuclease II activity
PESP_RS14190	COG2197	response regulator
PESP_RS14195	COG4585	Histidine kinase
PESP_RS14210	COG0584	glycerophosphoryl diester phosphodiesterase
PESP_RS14215	COG0840	transmembrane signaling receptor activity
PESP_RS14230	COG0784	Response regulator, receiver
PESP_RS14230	COG5002	protein histidine kinase activity
PESP_RS14235	COG1247	-acetyltransferase
PESP_RS14250	COG0625	glutathione transferase activity
PESP_RS14280	COG3954	Phosphoribulokinase
PESP_RS14290	COG1011	Hydrolase
PESP_RS14295	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PESP_RS14305	COG0849	cell division
PESP_RS14310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PESP_RS14315	COG1181	Belongs to the D-alanine--D-alanine ligase family
PESP_RS14320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PESP_RS14325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PESP_RS14330	COG0772	Belongs to the SEDS family
PESP_RS14335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PESP_RS14340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PESP_RS14345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PESP_RS14350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PESP_RS14355	COG0768	penicillin binding
PESP_RS14360	COG3116	cell division
PESP_RS14365	COG0275	rRNA processing
PESP_RS14370	COG2001	Belongs to the MraZ family
PESP_RS14390	COG0435	Glutathione S-transferase
PESP_RS14395	COG1741	Belongs to the pirin family
PESP_RS14405	COG0583	DNA-binding transcription factor activity
PESP_RS14410	COG1295	ribonuclease BN
PESP_RS14430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS14430	COG4191	Histidine kinase
PESP_RS14435	COG2204	response regulator
PESP_RS14445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PESP_RS14455	COG0792	nuclease activity
PESP_RS14465	COG2823	Periplasmic or secreted lipoprotein
PESP_RS14470	COG2969	positive regulation of protein catabolic process
PESP_RS14475	COG0625	glutathione transferase activity
PESP_RS14480	COG2857	Cytochrome c1
PESP_RS14485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PESP_RS14490	COG0723	plastoquinol--plastocyanin reductase activity
PESP_RS14495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PESP_RS14500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PESP_RS14505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PESP_RS14515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PESP_RS14525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PESP_RS14530	COG5007	Belongs to the BolA IbaG family
PESP_RS14540	COG2854	intermembrane phospholipid transfer
PESP_RS14545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PESP_RS14550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PESP_RS14555	COG1127	ABC transporter
PESP_RS14570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PESP_RS14585	COG1137	ATPase activity
PESP_RS14590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PESP_RS14605	COG1660	Displays ATPase and GTPase activities
PESP_RS14610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PESP_RS14615	COG2239	Acts as a magnesium transporter
PESP_RS14625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PESP_RS14630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PESP_RS14635	COG0352	thiamine-phosphate diphosphorylase activity
PESP_RS14640	COG2022	thiamine diphosphate biosynthetic process
PESP_RS14655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PESP_RS14670	COG1629	transport
PESP_RS14670	COG4774	siderophore transport
PESP_RS14680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PESP_RS14690	COG2003	Belongs to the UPF0758 family
PESP_RS14695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PESP_RS14705	COG4946	Tricorn protease homolog
PESP_RS14705	COG1506	peptidase
PESP_RS14705	COG0823	Involved in the tonB-independent uptake of proteins
PESP_RS14715	COG2081	HI0933 family
PESP_RS14720	COG1404	Belongs to the peptidase S8 family
PESP_RS14745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PESP_RS14750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PESP_RS14755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PESP_RS14760	COG0142	geranyltranstransferase activity
PESP_RS14765	COG0039	L-malate dehydrogenase activity
PESP_RS14770	COG1438	arginine binding
PESP_RS14780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PESP_RS14790	COG1840	ABC-type Fe3 transport system, periplasmic component
PESP_RS14795	COG3148	PFAM DTW domain containing protein
PESP_RS14800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PESP_RS14805	COG0508	dehydrogenase complex catalyzes the overall conversion of
PESP_RS14810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PESP_RS14815	COG2186	Transcriptional regulator
PESP_RS14820	COG1943	Transposase
PESP_RS14825	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PESP_RS14840	COG4969	Belongs to the N-Me-Phe pilin family
PESP_RS14850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PESP_RS14855	COG0237	dephospho-CoA kinase activity
PESP_RS14860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PESP_RS14865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PESP_RS14875	COG0745	RESPONSE REGULATOR receiver
PESP_RS14880	COG2205	protein histidine kinase activity
PESP_RS14885	COG2267	carboxylic ester hydrolase activity
PESP_RS14895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PESP_RS14900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PESP_RS14905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PESP_RS14910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PESP_RS14915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PESP_RS14920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PESP_RS14925	COG4942	peptidase
PESP_RS14930	COG0793	Belongs to the peptidase S41A family
PESP_RS14945	COG2177	Part of the ABC transporter FtsEX involved in
PESP_RS14950	COG2884	Cell division ATP-binding protein ftsE
PESP_RS14955	COG0552	protein localization to endoplasmic reticulum
PESP_RS14960	COG0742	ribosomal rna small subunit methyltransferase
PESP_RS14965	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PESP_RS14985	COG2264	protein methyltransferase activity
PESP_RS14990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PESP_RS14995	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PESP_RS15000	COG0138	bifunctional purine biosynthesis protein purh
PESP_RS15010	COG0151	Belongs to the GarS family
PESP_RS15015	COG5001	Diguanylate cyclase
PESP_RS15030	COG0123	including yeast histone deacetylase and acetoin utilization protein
PESP_RS15045	COG1280	lysine exporter protein (LysE YggA)
PESP_RS15065	COG0840	transmembrane signaling receptor activity
PESP_RS15070	COG0583	DNA-binding transcription factor activity
PESP_RS15090	COG2823	Periplasmic or secreted lipoprotein
PESP_RS15120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PESP_RS15125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PESP_RS15130	COG1862	Preprotein translocase
PESP_RS15135	COG0343	queuine tRNA-ribosyltransferase activity
PESP_RS15140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PESP_RS15145	COG5001	Diguanylate cyclase
PESP_RS15145	COG5002	protein histidine kinase activity
PESP_RS15155	COG0583	DNA-binding transcription factor activity
PESP_RS15160	COG0306	phosphate transporter
PESP_RS15165	COG1392	Phosphate transport regulator
PESP_RS15175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PESP_RS15180	COG0573	inorganic phosphate transmembrane transporter activity
PESP_RS15200	COG0248	Ppx GppA phosphatase
PESP_RS15210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PESP_RS15235	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PESP_RS15245	COG2824	Alkylphosphonate utilization operon protein PhnA
PESP_RS15255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PESP_RS15280	COG1388	LysM domain
PESP_RS15280	COG0741	lytic transglycosylase activity
PESP_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS15295	COG3618	amidohydrolase
PESP_RS15305	COG4948	Mandelate Racemase Muconate Lactonizing
PESP_RS15330	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
PESP_RS15350	COG5002	protein histidine kinase activity
PESP_RS15350	COG2205	protein histidine kinase activity
PESP_RS15350	COG0784	Response regulator, receiver
PESP_RS15360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PESP_RS15365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PESP_RS15375	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PESP_RS15380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PESP_RS15385	COG0330	HflC and HflK could
PESP_RS15390	COG0330	HflC and HflK could
PESP_RS15395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PESP_RS15400	COG1923	regulation of RNA biosynthetic process
PESP_RS15405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PESP_RS15410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PESP_RS15415	COG0860	N-Acetylmuramoyl-L-alanine amidase
PESP_RS15420	COG0802	atpase or kinase
PESP_RS15425	COG0439	Biotin carboxylase
PESP_RS15430	COG0511	ligase activity, forming carbon-carbon bonds
PESP_RS15435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PESP_RS15440	COG4232	protein-disulfide reductase activity
PESP_RS15445	COG1324	tolerance protein
PESP_RS15450	COG3030	protein affecting phage T7 exclusion by the F plasmid
PESP_RS15455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PESP_RS15460	COG0459	protein refolding
PESP_RS15480	COG0346	lactoylglutathione lyase activity
PESP_RS15485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PESP_RS15485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PESP_RS15510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PESP_RS15515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PESP_RS15520	COG1561	YicC-like family, N-terminal region
PESP_RS15530	COG2197	response regulator
PESP_RS15535	COG4585	Histidine kinase
PESP_RS15540	COG2815	serine threonine protein kinase
PESP_RS15540	COG0515	serine threonine protein kinase
PESP_RS15555	COG1404	Belongs to the peptidase S8 family
PESP_RS15560	COG0194	GDP metabolic process
PESP_RS15565	COG1758	RNA polymerase activity
PESP_RS15570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PESP_RS15590	COG1522	sequence-specific DNA binding
PESP_RS15595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PESP_RS15600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PESP_RS15625	COG0203	ribosomal protein L17
PESP_RS15630	COG0202	RNA polymerase activity
PESP_RS15635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PESP_RS15640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PESP_RS15645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PESP_RS15650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PESP_RS15655	COG0201	protein transport
PESP_RS15660	COG0200	Binds to the 23S rRNA
PESP_RS15665	COG1841	ribosomal large subunit assembly
PESP_RS15670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PESP_RS15675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PESP_RS15680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PESP_RS15685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PESP_RS15690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PESP_RS15695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PESP_RS15700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PESP_RS15705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PESP_RS15735	COG0640	Transcriptional regulator
PESP_RS15755	COG3713	MltA-interacting MipA family protein
PESP_RS15775	COG1132	(ABC) transporter
PESP_RS15780	COG2885	chlorophyll binding
PESP_RS15790	COG0668	transmembrane transport
PESP_RS15795	COG0204	Acyl-transferase
PESP_RS15800	COG0204	Acyl-transferase
PESP_RS15805	COG1166	arginine decarboxylase activity
PESP_RS15810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PESP_RS15830	COG1082	Xylose isomerase domain protein TIM barrel
PESP_RS15845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PESP_RS15860	COG2183	response to ionizing radiation
PESP_RS15880	COG1040	competence protein
PESP_RS15890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PESP_RS15890	COG0316	Belongs to the HesB IscA family
PESP_RS15900	COG0534	Mate efflux family protein
PESP_RS15905	COG0726	polysaccharide deacetylase
PESP_RS15910	COG2201	protein-glutamate methylesterase activity
PESP_RS15915	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PESP_RS15920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PESP_RS15930	COG0835	chemotaxis
PESP_RS15935	COG0643	Histidine kinase
PESP_RS15935	COG2198	Histidine kinase
PESP_RS15955	COG0109	protoheme IX farnesyltransferase activity
PESP_RS15960	COG1612	heme a metabolic process
PESP_RS15980	COG1845	cytochrome c oxidase, subunit III
PESP_RS15985	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PESP_RS15990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PESP_RS16045	COG0583	DNA-binding transcription factor activity
PESP_RS16050	COG0431	NADPH-dependent FMN reductase
PESP_RS16080	COG0066	3-isopropylmalate dehydratase activity
PESP_RS16085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PESP_RS16090	COG0473	3-isopropylmalate dehydrogenase activity
PESP_RS16095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PESP_RS16110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PESP_RS16115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PESP_RS16120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
PESP_RS16125	COG0545	Peptidyl-prolyl cis-trans isomerase
PESP_RS16135	COG2900	Belongs to the SlyX family
PESP_RS16140	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PESP_RS16145	COG0488	(ABC) transporter
PESP_RS16155	COG0429	hydrolase of the alpha beta-hydrolase fold
PESP_RS16160	COG3089	Belongs to the UPF0270 family
PESP_RS16170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PESP_RS16195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PESP_RS16205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PESP_RS16220	COG0537	adenosine 5'-monophosphoramidase activity
PESP_RS16235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PESP_RS16235	COG0662	Cupin 2, conserved barrel domain protein
PESP_RS16245	COG0436	Aminotransferase
PESP_RS16250	COG0235	Class ii aldolase
PESP_RS16255	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PESP_RS16265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PESP_RS16270	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PESP_RS16275	COG0069	glutamate synthase activity
PESP_RS16290	COG2226	methyltransferase
PESP_RS16305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PESP_RS16310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PESP_RS16315	COG0805	protein transport
PESP_RS16330	COG2203	Gaf domain
PESP_RS16330	COG3706	GGDEF domain
PESP_RS16330	COG4251	negative regulation of phosphorylation
PESP_RS16330	COG5001	Diguanylate cyclase
PESP_RS16345	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PESP_RS16350	COG2943	transferase activity, transferring hexosyl groups
PESP_RS16350	COG3416	Protein conserved in bacteria
PESP_RS16360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PESP_RS16365	COG4565	transcriptional regulatory protein
PESP_RS16370	COG3290	protein histidine kinase activity
PESP_RS16405	COG4681	YaeQ
PESP_RS16420	COG0783	Belongs to the Dps family
PESP_RS16430	COG1770	oligopeptidase
PESP_RS16435	COG3397	chitin binding
PESP_RS16485	COG3428	Bacterial PH domain
PESP_RS16510	COG2832	Protein of unknown function (DUF454)
PESP_RS16540	COG5520	Belongs to the glycosyl hydrolase 30 family
PESP_RS16540	COG4447	cellulose binding
PESP_RS16540	COG3291	Pkd domain containing protein
PESP_RS16580	COG4771	TonB-dependent receptor
PESP_RS16585	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PESP_RS16595	COG0730	response to heat
PESP_RS16600	COG2188	Transcriptional regulator
PESP_RS16605	COG0656	L-ascorbic acid biosynthetic process
PESP_RS16615	COG2855	membrane
PESP_RS16640	COG4771	TonB-dependent receptor
PESP_RS16660	COG0513	Belongs to the DEAD box helicase family
PESP_RS16665	COG0326	Molecular chaperone. Has ATPase activity
PESP_RS16675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PESP_RS16680	COG1349	DNA-binding transcription factor activity
PESP_RS16685	COG0110	maltose O-acetyltransferase activity
PESP_RS16715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PESP_RS16755	COG2963	transposase activity
PESP_RS16770	COG3710	Transcriptional regulator
PESP_RS16775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PESP_RS16780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PESP_RS16785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PESP_RS16790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PESP_RS16795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PESP_RS16800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PESP_RS16810	COG0356	it plays a direct role in the translocation of protons across the membrane
PESP_RS16820	COG1475	DNA binding
PESP_RS16825	COG1192	Involved in chromosome partitioning
PESP_RS16830	COG0357	Ribosomal RNA small subunit methyltransferase G
PESP_RS16835	COG0445	tRNA wobble uridine modification
PESP_RS16840	COG0716	FMN binding
PESP_RS16845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PESP_RS16850	COG0706	membrane insertase activity
PESP_RS16855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PESP_RS16860	COG0594	ribonuclease P activity
PESP_RS16865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PESP_RS16880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PESP_RS16885	COG1322	Protein conserved in bacteria
PESP_RS16920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PESP_RS16930	COG1794	racemase activity, acting on amino acids and derivatives
PESP_RS16935	COG0583	DNA-binding transcription factor activity
PESP_RS16945	COG0583	DNA-binding transcription factor activity
PESP_RS16950	COG0583	DNA-binding transcription factor activity
PESP_RS16955	COG3384	dioxygenase
PESP_RS16970	COG5001	Diguanylate cyclase
PESP_RS16980	COG0076	glutamate decarboxylase activity
PESP_RS16985	COG3486	L-lysine 6-monooxygenase (NADPH) activity
PESP_RS16995	COG4264	IucA IucC family
PESP_RS17010	COG3293	Transposase
PESP_RS17020	COG0583	DNA-binding transcription factor activity
PESP_RS17035	COG1136	(ABC) transporter
PESP_RS17035	COG0577	efflux transmembrane transporter activity
PESP_RS17050	COG0653	protein targeting
PESP_RS17065	COG1469	GTP cyclohydrolase I activity
PESP_RS17070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PESP_RS17105	COG0583	DNA-binding transcription factor activity
PESP_RS17130	COG2249	NAD(P)H dehydrogenase (quinone) activity
PESP_RS17150	COG3321	synthase
PESP_RS17150	COG0604	alcohol dehydrogenase
PESP_RS17155	COG0583	DNA-binding transcription factor activity
PESP_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS17200	COG0583	DNA-binding transcription factor activity
PESP_RS17210	COG2814	Major facilitator Superfamily
PESP_RS17255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PESP_RS17260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PESP_RS17265	COG4558	Periplasmic binding protein
PESP_RS17270	COG4771	TonB-dependent receptor
PESP_RS17290	COG0583	DNA-binding transcription factor activity
PESP_RS17315	COG1566	PFAM secretion protein HlyD family protein
PESP_RS17350	COG0300	oxidoreductase activity
PESP_RS17355	COG1960	acyl-CoA dehydrogenase activity
PESP_RS17430	COG0488	(ABC) transporter
PESP_RS17435	COG0385	Bile acid
PESP_RS17465	COG1573	uracil-dna glycosylase
PESP_RS17490	COG3040	lipid binding
PESP_RS17495	COG1671	Belongs to the UPF0178 family
PESP_RS17530	COG0420	3'-5' exonuclease activity
PESP_RS17560	COG0217	transcriptional regulatory protein
PESP_RS17580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PESP_RS17595	COG1278	Cold shock
PESP_RS17610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PESP_RS17615	COG0572	uridine kinase
PESP_RS17620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PESP_RS17625	COG0813	purine-nucleoside phosphorylase activity
PESP_RS17650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PESP_RS17655	COG3293	Transposase
PESP_RS17680	COG2205	protein histidine kinase activity
PESP_RS17685	COG0745	RESPONSE REGULATOR receiver
PESP_RS17710	COG3135	benzoate transporter
PESP_RS17715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PESP_RS17725	COG5002	protein histidine kinase activity
PESP_RS17740	COG3038	cytochrome b561
PESP_RS17745	COG2207	Transcriptional regulator
PESP_RS17750	COG4303	Ethanolamine ammonia lyase large subunit
PESP_RS17755	COG4302	ethanolamine ammonia-lyase activity
PESP_RS17760	COG0531	amino acid
PESP_RS17775	COG1252	NADH dehydrogenase
PESP_RS17780	COG0514	ATP-dependent DNA helicase (RecQ)
PESP_RS17795	COG2130	NADP-dependent
PESP_RS17805	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PESP_RS17860	COG0583	DNA-binding transcription factor activity
PESP_RS17865	COG2855	membrane
PESP_RS17870	COG0415	Belongs to the DNA photolyase family
PESP_RS17890	COG1160	GTP binding
PESP_RS17895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PESP_RS17900	COG2976	Protein conserved in bacteria
PESP_RS17905	COG0124	histidyl-tRNA synthetase
PESP_RS17910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PESP_RS17915	COG1426	Protein conserved in bacteria
PESP_RS17925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PESP_RS17930	COG0105	UTP biosynthetic process
PESP_RS17935	COG0826	peptidase U32
PESP_RS17940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PESP_RS17980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PESP_RS17985	COG0745	RESPONSE REGULATOR receiver
PESP_RS17990	COG1279	arginine transmembrane transporter activity
PESP_RS17995	COG0583	DNA-binding transcription factor activity
PESP_RS18005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PESP_RS18005	COG0515	serine threonine protein kinase
PESP_RS18020	COG4221	oxidoreductase activity
PESP_RS18025	COG0668	transmembrane transport
PESP_RS18030	COG3724	N-succinylarginine dihydrolase activity
PESP_RS18040	COG0604	alcohol dehydrogenase
PESP_RS18045	COG0583	DNA-binding transcription factor activity
PESP_RS18050	COG1846	Transcriptional regulator
PESP_RS18055	COG1764	response to oxidative stress
PESP_RS18060	COG0640	Transcriptional regulator
PESP_RS18065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PESP_RS18080	COG1309	transcriptional regulator
PESP_RS18105	COG0705	Rhomboid family
PESP_RS18120	COG0789	Transcriptional regulator
PESP_RS18140	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PESP_RS18185	COG0402	S-adenosylhomocysteine deaminase activity
PESP_RS18190	COG2351	hydroxyisourate hydrolase activity
PESP_RS18205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PESP_RS18215	COG3845	ABC transporter
PESP_RS18220	COG4603	Belongs to the binding-protein-dependent transport system permease family
PESP_RS18225	COG1079	Belongs to the binding-protein-dependent transport system permease family
PESP_RS18235	COG2233	PERMEase
PESP_RS18245	COG4771	TonB-dependent receptor
PESP_RS18255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS18255	COG4191	Histidine kinase
PESP_RS18260	COG4251	negative regulation of phosphorylation
PESP_RS18260	COG2203	Gaf domain
PESP_RS18260	COG3706	GGDEF domain
PESP_RS18260	COG5001	Diguanylate cyclase
PESP_RS18275	COG1979	alcohol dehydrogenase
PESP_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
PESP_RS18330	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PESP_RS18350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PESP_RS18355	COG0730	response to heat
PESP_RS18375	COG1309	transcriptional regulator
PESP_RS18415	COG0753	catalase activity
PESP_RS18420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PESP_RS18430	COG0246	Mannitol dehydrogenase
PESP_RS18435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PESP_RS18440	COG1966	Carbon starvation protein
PESP_RS18480	COG1609	Transcriptional regulator
PESP_RS18540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PESP_RS18545	COG4136	ATPase activity
PESP_RS18555	COG4134	Bacterial extracellular solute-binding protein
PESP_RS18620	COG0604	alcohol dehydrogenase
PESP_RS18635	COG1609	Transcriptional regulator
PESP_RS18645	COG1280	lysine exporter protein (LysE YggA)
PESP_RS18710	COG3279	Response regulator of the LytR AlgR family
PESP_RS18715	COG3275	phosphorelay sensor kinase activity
PESP_RS18720	COG1228	amidohydrolase
PESP_RS18730	COG0583	DNA-binding transcription factor activity
PESP_RS18735	COG3321	synthase
PESP_RS18735	COG0604	alcohol dehydrogenase
PESP_RS18760	COG0457	Tetratricopeptide repeat
PESP_RS18765	COG4771	TonB-dependent receptor
PESP_RS18770	COG1902	pentaerythritol trinitrate reductase activity
PESP_RS18775	COG2814	Major facilitator Superfamily
PESP_RS18785	COG2186	Transcriptional regulator
PESP_RS18790	COG0673	inositol 2-dehydrogenase activity
PESP_RS18845	COG4638	Rieske (2fe-2S)
PESP_RS18855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PESP_RS18865	COG3634	alkyl hydroperoxide reductase activity
PESP_RS18875	COG2205	protein histidine kinase activity
PESP_RS18875	COG0784	Response regulator, receiver
PESP_RS18900	COG4667	esterase of the alpha-beta hydrolase superfamily
PESP_RS18920	COG3706	GGDEF domain
PESP_RS18920	COG2203	Gaf domain
PESP_RS18920	COG5001	Diguanylate cyclase
PESP_RS18920	COG4251	negative regulation of phosphorylation
PESP_RS18940	COG0840	transmembrane signaling receptor activity
PESP_RS18950	COG2906	2 iron, 2 sulfur cluster binding
PESP_RS18955	COG2193	ferroxidase activity
PESP_RS18960	COG2193	ferroxidase activity
PESP_RS19000	COG3293	Transposase
PESP_RS19005	COG1435	thymidine kinase activity
PESP_RS19010	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
PESP_RS19015	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PESP_RS19025	COG0457	Tetratricopeptide repeat
PESP_RS19045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PESP_RS19050	COG0346	lactoylglutathione lyase activity
PESP_RS19055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PESP_RS19070	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PESP_RS19080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PESP_RS19120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PESP_RS19125	COG0295	cytidine deaminase activity
PESP_RS19135	COG0010	Belongs to the arginase family
PESP_RS19145	COG1253	flavin adenine dinucleotide binding
PESP_RS19195	COG1595	DNA-templated transcription, initiation
PESP_RS19200	COG1597	lipid kinase activity
PESP_RS19200	COG1803	Methylglyoxal synthase
PESP_RS19205	COG4628	conserved protein (DUF2132)
PESP_RS19220	COG0625	glutathione transferase activity
PESP_RS19225	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PESP_RS19285	COG1757	Na H antiporter
PESP_RS19300	COG3008	intermembrane lipid transfer
PESP_RS19300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PESP_RS19305	COG2995	paraquat-inducible protein a
PESP_RS19325	COG0443	Heat shock 70 kDa protein
PESP_RS19330	COG0484	heat shock protein binding
PESP_RS19335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PESP_RS19345	COG2205	protein histidine kinase activity
PESP_RS19345	COG2198	Histidine kinase
PESP_RS19345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PESP_RS19345	COG0784	Response regulator, receiver
PESP_RS19360	COG4191	Histidine kinase
PESP_RS19365	COG0471	metal ion transport
PESP_RS19385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PESP_RS19420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PESP_RS19485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PESP_RS19495	COG3769	mannosylglycerate metabolic process
PESP_RS19500	COG1215	transferase activity, transferring glycosyl groups
PESP_RS19505	COG0366	Alpha amylase catalytic
PESP_RS19520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PESP_RS19525	COG0254	rRNA binding
PESP_RS19540	COG0583	DNA-binding transcription factor activity
PESP_RS19545	COG2814	Major facilitator Superfamily
PESP_RS19550	COG0656	L-ascorbic acid biosynthetic process
PESP_RS19565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PESP_RS19570	COG0513	Belongs to the DEAD box helicase family
PESP_RS19575	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PESP_RS19580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PESP_RS19610	COG1012	belongs to the aldehyde dehydrogenase family
PESP_RS19615	COG1309	transcriptional regulator
PESP_RS19650	COG1012	belongs to the aldehyde dehydrogenase family
PESP_RS19660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PESP_RS19665	COG1522	sequence-specific DNA binding
PESP_RS19690	COG1640	4-alpha-glucanotransferase
PESP_RS19695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PESP_RS19705	COG0058	SHG alpha-glucan phosphorylase activity
PESP_RS19710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PESP_RS19715	COG0297	glycogen (starch) synthase activity
PESP_RS19720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PESP_RS19750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PESP_RS19755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PESP_RS19785	COG1272	protein, Hemolysin III
PESP_RS19805	COG1595	DNA-templated transcription, initiation
PESP_RS19820	COG0415	Belongs to the DNA photolyase family
PESP_RS19830	COG4221	oxidoreductase activity
PESP_RS19835	COG1233	COG1233 Phytoene dehydrogenase and related
PESP_RS19845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PESP_RS19870	COG0440	acetolactate synthase activity
PESP_RS19875	COG0028	Belongs to the TPP enzyme family
PESP_RS19885	COG0473	3-isopropylmalate dehydrogenase activity
PESP_RS19900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PESP_RS19905	COG1611	Belongs to the LOG family
PESP_RS19925	COG2873	o-acetylhomoserine
PESP_RS19930	COG3306	glycosyltransferase involved in LPS biosynthesis
PESP_RS19945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PESP_RS19945	COG0140	phosphoribosyl-ATP diphosphatase activity
PESP_RS19950	COG0107	imidazoleglycerol-phosphate synthase activity
PESP_RS19955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PESP_RS19960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PESP_RS19965	COG0131	Imidazoleglycerol-phosphate dehydratase
PESP_RS19965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PESP_RS19970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PESP_RS19975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PESP_RS19980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PESP_RS20015	COG1199	ATP-dependent helicase activity
PESP_RS20030	COG1785	Belongs to the alkaline phosphatase family
PESP_RS20040	COG0318	PFAM AMP-dependent synthetase and ligase
PESP_RS20050	COG0564	pseudouridine synthase activity
PESP_RS20065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PESP_RS20070	COG2894	cell division
PESP_RS20075	COG0850	regulation of cytokinetic process
PESP_RS20080	COG3100	YcgL domain-containing protein
PESP_RS20085	COG2951	lytic endotransglycosylase activity
PESP_RS20100	COG1228	amidohydrolase
PESP_RS20110	COG2983	Belongs to the UPF0260 family
PESP_RS20150	COG0811	peptide transport
PESP_RS20155	COG0811	peptide transport
PESP_RS20160	COG0848	biopolymer transport protein
PESP_RS20165	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PESP_RS20200	COG3706	GGDEF domain
PESP_RS20225	COG4895	conserved protein (DUF2196)
PESP_RS20260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PESP_RS20265	COG4667	esterase of the alpha-beta hydrolase superfamily
PESP_RS20275	COG2169	Transcriptional regulator
PESP_RS20285	COG2423	ornithine cyclodeaminase activity
PESP_RS20295	COG1115	amino acid carrier protein
PESP_RS20320	COG3263	regulation of cellular component size
PESP_RS20325	COG0277	FAD linked oxidase domain protein
PESP_RS20325	COG0247	lactate metabolic process
PESP_RS20335	COG0574	Belongs to the PEP-utilizing enzyme family
PESP_RS20335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PESP_RS20340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PESP_RS20345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase