locus-tag	class	description
PSHA_RS00010	COG0592	DNA-directed DNA polymerase activity
PSHA_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PSHA_RS00020	COG0187	DNA topoisomerase II activity
PSHA_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
PSHA_RS00030	COG0751	glycine-tRNA ligase activity
PSHA_RS00045	COG0425	Belongs to the sulfur carrier protein TusA family
PSHA_RS00050	COG0183	Belongs to the thiolase family
PSHA_RS00060	COG0741	lytic transglycosylase activity
PSHA_RS00065	COG0006	proline dipeptidase activity
PSHA_RS00070	COG1739	Uncharacterized protein family UPF0029
PSHA_RS00075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PSHA_RS00100	COG0569	domain protein
PSHA_RS00105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PSHA_RS00105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PSHA_RS00110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PSHA_RS00115	COG0242	peptide deformylase activity
PSHA_RS00125	COG0758	DNA mediated transformation
PSHA_RS00130	COG2922	Belongs to the Smg family
PSHA_RS00135	COG0551	DNA topoisomerase type I activity
PSHA_RS00140	COG0009	L-threonylcarbamoyladenylate synthase
PSHA_RS00145	COG0408	coproporphyrinogen oxidase activity
PSHA_RS00155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PSHA_RS00165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PSHA_RS00205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PSHA_RS00265	COG2205	protein histidine kinase activity
PSHA_RS00265	COG0784	Response regulator, receiver
PSHA_RS00270	COG1522	sequence-specific DNA binding
PSHA_RS00280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PSHA_RS00305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PSHA_RS00320	COG0386	Belongs to the glutathione peroxidase family
PSHA_RS00330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PSHA_RS00350	COG1404	Belongs to the peptidase S8 family
PSHA_RS00355	COG1770	oligopeptidase
PSHA_RS00365	COG1238	metal cluster binding
PSHA_RS00370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PSHA_RS00375	COG0302	gtp cyclohydrolase
PSHA_RS00385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PSHA_RS00390	COG3132	Protein of unknown function, DUF480
PSHA_RS00395	COG0784	Response regulator, receiver
PSHA_RS00395	COG5002	protein histidine kinase activity
PSHA_RS00395	COG2205	protein histidine kinase activity
PSHA_RS00400	COG1944	ATP diphosphatase activity
PSHA_RS00415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PSHA_RS00415	COG3153	acetyltransferase
PSHA_RS00435	COG1187	pseudouridine synthase activity
PSHA_RS00455	COG1011	Hydrolase
PSHA_RS00460	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PSHA_RS00470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PSHA_RS00475	COG0019	diaminopimelate decarboxylase activity
PSHA_RS00485	COG1965	Belongs to the frataxin family
PSHA_RS00490	COG0400	carboxylic ester hydrolase activity
PSHA_RS00500	COG0181	hydroxymethylbilane synthase activity
PSHA_RS00505	COG2959	enzyme of heme biosynthesis
PSHA_RS00520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PSHA_RS00525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PSHA_RS00525	COG0617	tRNA 3'-terminal CCA addition
PSHA_RS00525	COG0517	IMP dehydrogenase activity
PSHA_RS00535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PSHA_RS00545	COG2354	Protein conserved in bacteria
PSHA_RS00550	COG4774	siderophore transport
PSHA_RS00555	COG0513	Belongs to the DEAD box helicase family
PSHA_RS00575	COG3118	belongs to the thioredoxin family
PSHA_RS00580	COG0513	Belongs to the DEAD box helicase family
PSHA_RS00585	COG0248	Ppx GppA phosphatase
PSHA_RS00605	COG1444	tRNA N-acetyltransferase activity
PSHA_RS00610	COG0210	DNA helicase
PSHA_RS00630	COG1011	Hydrolase
PSHA_RS00635	COG0494	nUDIX hydrolase
PSHA_RS00640	COG1218	3'(2'),5'-bisphosphate nucleotidase
PSHA_RS00665	COG0606	chelatase, subunit chli
PSHA_RS00680	COG1253	flavin adenine dinucleotide binding
PSHA_RS00695	COG2031	fatty acid transporter
PSHA_RS00720	COG1946	Acyl-CoA thioesterase
PSHA_RS00725	COG2937	Belongs to the GPAT DAPAT family
PSHA_RS00730	COG0051	transcription antitermination factor activity, RNA binding
PSHA_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PSHA_RS00740	COG0088	Forms part of the polypeptide exit tunnel
PSHA_RS00745	COG0089	rRNA binding
PSHA_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PSHA_RS00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PSHA_RS00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PSHA_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PSHA_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PSHA_RS00775	COG0255	Belongs to the universal ribosomal protein uL29 family
PSHA_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PSHA_RS00785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PSHA_RS00790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PSHA_RS00830	COG2204	response regulator
PSHA_RS00835	COG3852	Histidine kinase
PSHA_RS00845	COG0174	glutamine synthetase
PSHA_RS00850	COG1217	gtp-binding protein TYPA
PSHA_RS00865	COG1295	ribonuclease BN
PSHA_RS00870	COG1490	D-aminoacyl-tRNA deacylase activity
PSHA_RS00880	COG0456	acetyltransferase
PSHA_RS00895	COG0019	diaminopimelate decarboxylase activity
PSHA_RS00905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PSHA_RS00915	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PSHA_RS00920	COG2885	chlorophyll binding
PSHA_RS00925	COG1049	propionate catabolic process, 2-methylcitrate cycle
PSHA_RS00935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PSHA_RS00950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PSHA_RS00975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PSHA_RS00985	COG1012	belongs to the aldehyde dehydrogenase family
PSHA_RS00995	COG1765	OsmC-like protein
PSHA_RS01000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PSHA_RS01005	COG0814	amino acid
PSHA_RS01020	COG1218	3'(2'),5'-bisphosphate nucleotidase
PSHA_RS01025	COG0529	Catalyzes the synthesis of activated sulfate
PSHA_RS01030	COG0471	metal ion transport
PSHA_RS01030	COG3273	potassium ion transport
PSHA_RS01035	COG2895	sulfate adenylyltransferase (ATP) activity
PSHA_RS01040	COG0175	sulfate reduction
PSHA_RS01045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PSHA_RS01045	COG1648	precorrin-2 dehydrogenase activity
PSHA_RS01050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PSHA_RS01065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PSHA_RS01070	COG0250	Participates in transcription elongation, termination and antitermination
PSHA_RS01075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PSHA_RS01080	COG0081	regulation of translation
PSHA_RS01085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PSHA_RS01090	COG0222	ribosome binding
PSHA_RS01095	COG0085	RNA polymerase activity
PSHA_RS01100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PSHA_RS01105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PSHA_RS01110	COG0049	tRNA binding
PSHA_RS01115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PSHA_RS01120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PSHA_RS01125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PSHA_RS01130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PSHA_RS01140	COG3031	protein transport across the cell outer membrane
PSHA_RS01150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSHA_RS01155	COG1459	type II secretion system
PSHA_RS01160	COG2165	general secretion pathway protein
PSHA_RS01170	COG2165	general secretion pathway protein
PSHA_RS01190	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PSHA_RS01215	COG0348	domain, Protein
PSHA_RS01220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PSHA_RS01225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PSHA_RS01235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PSHA_RS01245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PSHA_RS01250	COG0724	RNA recognition motif
PSHA_RS01280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PSHA_RS01285	COG0459	protein refolding
PSHA_RS01290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PSHA_RS01295	COG3030	protein affecting phage T7 exclusion by the F plasmid
PSHA_RS01300	COG1324	tolerance protein
PSHA_RS01305	COG4232	protein-disulfide reductase activity
PSHA_RS01310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PSHA_RS01315	COG0511	ligase activity, forming carbon-carbon bonds
PSHA_RS01320	COG0439	Biotin carboxylase
PSHA_RS01325	COG0802	atpase or kinase
PSHA_RS01330	COG0860	N-Acetylmuramoyl-L-alanine amidase
PSHA_RS01335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PSHA_RS01340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PSHA_RS01345	COG1923	regulation of RNA biosynthetic process
PSHA_RS01350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PSHA_RS01355	COG0330	HflC and HflK could
PSHA_RS01360	COG0330	HflC and HflK could
PSHA_RS01365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PSHA_RS01370	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PSHA_RS01380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PSHA_RS01385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PSHA_RS01430	COG4948	Mandelate Racemase Muconate Lactonizing
PSHA_RS01445	COG3618	amidohydrolase
PSHA_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS01460	COG0741	lytic transglycosylase activity
PSHA_RS01460	COG1388	LysM domain
PSHA_RS01470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PSHA_RS01480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PSHA_RS01490	COG2824	Alkylphosphonate utilization operon protein PhnA
PSHA_RS01515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSHA_RS01525	COG2716	regulation of RNA biosynthetic process
PSHA_RS01535	COG0581	inorganic phosphate transmembrane transporter activity
PSHA_RS01540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PSHA_RS01550	COG1392	Phosphate transport regulator
PSHA_RS01555	COG0306	phosphate transporter
PSHA_RS01560	COG0583	DNA-binding transcription factor activity
PSHA_RS01570	COG5001	Diguanylate cyclase
PSHA_RS01570	COG5002	protein histidine kinase activity
PSHA_RS01575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PSHA_RS01580	COG0343	queuine tRNA-ribosyltransferase activity
PSHA_RS01585	COG1862	Preprotein translocase
PSHA_RS01590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PSHA_RS01595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PSHA_RS01610	COG2823	Periplasmic or secreted lipoprotein
PSHA_RS01650	COG1280	lysine exporter protein (LysE YggA)
PSHA_RS01665	COG0123	including yeast histone deacetylase and acetoin utilization protein
PSHA_RS01685	COG0675	Transposase, IS605 OrfB family
PSHA_RS01690	COG0151	Belongs to the GarS family
PSHA_RS01700	COG0138	bifunctional purine biosynthesis protein purh
PSHA_RS01705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PSHA_RS01710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PSHA_RS01715	COG2264	protein methyltransferase activity
PSHA_RS01735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PSHA_RS01740	COG0742	ribosomal rna small subunit methyltransferase
PSHA_RS01750	COG0552	protein localization to endoplasmic reticulum
PSHA_RS01755	COG2884	Cell division ATP-binding protein ftsE
PSHA_RS01760	COG2177	Part of the ABC transporter FtsEX involved in
PSHA_RS01785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PSHA_RS01790	COG0339	signal peptide processing
PSHA_RS01795	COG0742	ribosomal rna small subunit methyltransferase
PSHA_RS01805	COG0793	Belongs to the peptidase S41A family
PSHA_RS01810	COG4942	peptidase
PSHA_RS01815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PSHA_RS01820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PSHA_RS01830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PSHA_RS01835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PSHA_RS01840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PSHA_RS01850	COG2267	carboxylic ester hydrolase activity
PSHA_RS01855	COG2205	protein histidine kinase activity
PSHA_RS01860	COG0745	RESPONSE REGULATOR receiver
PSHA_RS01870	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PSHA_RS01875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSHA_RS01880	COG0237	dephospho-CoA kinase activity
PSHA_RS01885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PSHA_RS01915	COG3023	N-Acetylmuramoyl-L-alanine amidase
PSHA_RS01920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PSHA_RS01925	COG2186	Transcriptional regulator
PSHA_RS01930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PSHA_RS01935	COG0508	dehydrogenase complex catalyzes the overall conversion of
PSHA_RS01940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PSHA_RS01945	COG3148	PFAM DTW domain containing protein
PSHA_RS01950	COG0840	transmembrane signaling receptor activity
PSHA_RS01965	COG0668	transmembrane transport
PSHA_RS01970	COG3137	Salt-induced outer membrane protein
PSHA_RS01980	COG1250	3-hydroxyacyl-CoA dehydrogenase
PSHA_RS02010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PSHA_RS02015	COG1484	DNA-dependent DNA replication
PSHA_RS02030	COG2433	Pfam Transposase IS66
PSHA_RS02060	COG0582	viral genome integration into host DNA
PSHA_RS02105	COG1288	antiporter activity
PSHA_RS02120	COG3706	GGDEF domain
PSHA_RS02150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PSHA_RS02160	COG1227	inorganic diphosphatase activity
PSHA_RS02190	COG4181	ATPase activity
PSHA_RS02205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PSHA_RS02215	COG3300	MHYT domain
PSHA_RS02215	COG5001	Diguanylate cyclase
PSHA_RS02245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PSHA_RS02260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PSHA_RS02270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PSHA_RS02275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PSHA_RS02295	COG1509	lysine 2,3-aminomutase activity
PSHA_RS02300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PSHA_RS02305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PSHA_RS02310	COG1629	transport
PSHA_RS02310	COG4774	siderophore transport
PSHA_RS02325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PSHA_RS02340	COG2022	thiamine diphosphate biosynthetic process
PSHA_RS02355	COG0688	phosphatidylethanolamine metabolic process
PSHA_RS02365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PSHA_RS02385	COG0432	Pfam Uncharacterised protein family UPF0047
PSHA_RS02395	COG0735	belongs to the Fur family
PSHA_RS02420	COG1842	Phage shock protein A
PSHA_RS02460	COG1032	radical SAM domain protein
PSHA_RS02470	COG0513	Belongs to the DEAD box helicase family
PSHA_RS02475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PSHA_RS02485	COG0716	FMN binding
PSHA_RS02495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PSHA_RS02500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PSHA_RS02505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PSHA_RS02510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PSHA_RS02545	COG3876	Protein conserved in bacteria
PSHA_RS02550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PSHA_RS02555	COG1757	Na H antiporter
PSHA_RS02570	COG0625	glutathione transferase activity
PSHA_RS02575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PSHA_RS02585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PSHA_RS02595	COG2137	regulation of response to DNA damage stimulus
PSHA_RS02600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PSHA_RS02610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PSHA_RS02630	COG3630	sodium ion export across plasma membrane
PSHA_RS02645	COG4989	oxidoreductase activity
PSHA_RS02655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PSHA_RS02660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PSHA_RS02665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PSHA_RS02675	COG1469	GTP cyclohydrolase I activity
PSHA_RS02680	COG2198	Histidine kinase
PSHA_RS02680	COG0784	Response regulator, receiver
PSHA_RS02680	COG5002	protein histidine kinase activity
PSHA_RS02685	COG0745	RESPONSE REGULATOR receiver
PSHA_RS02690	COG2813	Specifically methylates the guanine in position
PSHA_RS02695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PSHA_RS02700	COG1194	a g-specific adenine glycosylase
PSHA_RS02705	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PSHA_RS02710	COG5002	protein histidine kinase activity
PSHA_RS02710	COG2205	protein histidine kinase activity
PSHA_RS02710	COG0784	Response regulator, receiver
PSHA_RS02750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSHA_RS02760	COG0006	proline dipeptidase activity
PSHA_RS02765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PSHA_RS02770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PSHA_RS02815	COG2207	Transcriptional regulator
PSHA_RS02820	COG1979	alcohol dehydrogenase
PSHA_RS02825	COG0789	Transcriptional regulator
PSHA_RS02860	COG0675	Transposase, IS605 OrfB family
PSHA_RS02875	COG0784	Response regulator, receiver
PSHA_RS02875	COG2198	Histidine kinase
PSHA_RS02875	COG2205	protein histidine kinase activity
PSHA_RS02885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PSHA_RS02900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PSHA_RS02915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PSHA_RS02920	COG0126	phosphoglycerate kinase activity
PSHA_RS02930	COG0745	RESPONSE REGULATOR receiver
PSHA_RS02935	COG5002	protein histidine kinase activity
PSHA_RS02950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PSHA_RS02955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PSHA_RS02960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PSHA_RS02970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PSHA_RS02980	COG1489	DNA binding
PSHA_RS03010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PSHA_RS03035	COG2205	protein histidine kinase activity
PSHA_RS03045	COG2204	response regulator
PSHA_RS03060	COG0617	tRNA 3'-terminal CCA addition
PSHA_RS03065	COG0642	Histidine kinase
PSHA_RS03070	COG0745	RESPONSE REGULATOR receiver
PSHA_RS03085	COG0697	spore germination
PSHA_RS03090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PSHA_RS03100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PSHA_RS03125	COG0513	Belongs to the DEAD box helicase family
PSHA_RS03140	COG0612	Peptidase, M16
PSHA_RS03145	COG2203	Gaf domain
PSHA_RS03145	COG3706	GGDEF domain
PSHA_RS03145	COG4251	negative regulation of phosphorylation
PSHA_RS03145	COG5001	Diguanylate cyclase
PSHA_RS03150	COG1045	serine acetyltransferase
PSHA_RS03160	COG1570	exodeoxyribonuclease VII activity
PSHA_RS03165	COG0517	IMP dehydrogenase activity
PSHA_RS03165	COG0516	GMP reductase activity
PSHA_RS03170	COG0519	Catalyzes the synthesis of GMP from XMP
PSHA_RS03170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PSHA_RS03175	COG0477	Major facilitator Superfamily
PSHA_RS03180	COG1309	transcriptional regulator
PSHA_RS03195	COG0456	acetyltransferase
PSHA_RS03200	COG2198	Histidine kinase
PSHA_RS03200	COG5002	protein histidine kinase activity
PSHA_RS03200	COG0784	Response regulator, receiver
PSHA_RS03205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PSHA_RS03210	COG0018	arginyl-trna synthetase
PSHA_RS03215	COG0259	pyridoxamine-phosphate oxidase activity
PSHA_RS03220	COG0084	hydrolase, TatD family'
PSHA_RS03230	COG0560	Phosphoserine phosphatase
PSHA_RS03255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PSHA_RS03260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PSHA_RS03265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PSHA_RS03275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PSHA_RS03280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PSHA_RS03285	COG3123	guanosine phosphorylase activity
PSHA_RS03320	COG3283	Transcriptional regulator of aromatic amino acids metabolism
PSHA_RS03340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PSHA_RS03345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PSHA_RS03350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PSHA_RS03355	COG0585	pseudouridine synthase activity
PSHA_RS03360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PSHA_RS03365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PSHA_RS03385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PSHA_RS03400	COG4773	Receptor
PSHA_RS03410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PSHA_RS03420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PSHA_RS03425	COG0788	formyltetrahydrofolate deformylase activity
PSHA_RS03440	COG0438	transferase activity, transferring glycosyl groups
PSHA_RS03475	COG2239	Acts as a magnesium transporter
PSHA_RS03485	COG0668	transmembrane transport
PSHA_RS03490	COG1346	cytolysis
PSHA_RS03500	COG1250	3-hydroxyacyl-CoA dehydrogenase
PSHA_RS03500	COG1024	Enoyl-CoA hydratase
PSHA_RS03505	COG3099	Belongs to the UPF0263 family
PSHA_RS03520	COG1047	Peptidyl-prolyl cis-trans
PSHA_RS03530	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PSHA_RS03540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PSHA_RS03545	COG1595	DNA-templated transcription, initiation
PSHA_RS03555	COG3026	antisigma factor binding
PSHA_RS03565	COG0481	GTPase activity
PSHA_RS03575	COG0571	ribonuclease III activity
PSHA_RS03585	COG1381	Involved in DNA repair and RecF pathway recombination
PSHA_RS03590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PSHA_RS03600	COG3437	response regulator, receiver
PSHA_RS03600	COG3850	Histidine kinase
PSHA_RS03600	COG4999	Histidine kinase
PSHA_RS03600	COG2205	protein histidine kinase activity
PSHA_RS03605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PSHA_RS03610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PSHA_RS03615	COG3956	TIGRFAM MazG family protein
PSHA_RS03620	COG0504	CTP synthase activity
PSHA_RS03625	COG0148	phosphopyruvate hydratase activity
PSHA_RS03630	COG3066	DNA modification
PSHA_RS03635	COG1051	belongs to the nudix hydrolase family
PSHA_RS03640	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PSHA_RS03645	COG0730	response to heat
PSHA_RS03650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PSHA_RS03655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PSHA_RS03660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PSHA_RS03705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PSHA_RS03705	COG0678	peroxiredoxin activity
PSHA_RS03710	COG0583	DNA-binding transcription factor activity
PSHA_RS03740	COG0835	chemotaxis
PSHA_RS03740	COG0784	Response regulator, receiver
PSHA_RS03745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PSHA_RS03750	COG1815	bacterial-type flagellum-dependent cell motility
PSHA_RS03770	COG4786	Flagellar basal body rod
PSHA_RS03775	COG4786	Flagellar basal body rod
PSHA_RS03780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PSHA_RS03785	COG1706	bacterial-type flagellum-dependent cell motility
PSHA_RS03790	COG1705	Flagellar rod assembly protein muramidase FlgJ
PSHA_RS03790	COG3951	Flagellar rod assembly protein muramidase FlgJ
PSHA_RS03795	COG1256	bacterial-type flagellum assembly
PSHA_RS03815	COG1334	flagellar protein FlaG
PSHA_RS03840	COG0519	Catalyzes the synthesis of GMP from XMP
PSHA_RS03855	COG1677	Flagellar hook-basal body complex protein FliE
PSHA_RS03865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PSHA_RS03885	COG3144	bacterial-type flagellum assembly
PSHA_RS03905	COG3190	flagellar
PSHA_RS03915	COG1987	bacterial-type flagellum assembly
PSHA_RS03930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PSHA_RS03955	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PSHA_RS03960	COG2198	Histidine kinase
PSHA_RS03960	COG0784	Response regulator, receiver
PSHA_RS03960	COG0643	Histidine kinase
PSHA_RS03965	COG2201	protein-glutamate methylesterase activity
PSHA_RS03970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PSHA_RS03975	COG1360	Flagellar Motor Protein
PSHA_RS03980	COG1192	Involved in chromosome partitioning
PSHA_RS03990	COG0835	chemotaxis
PSHA_RS04010	COG4133	protoheme IX ABC transporter activity
PSHA_RS04015	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PSHA_RS04020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PSHA_RS04025	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PSHA_RS04030	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PSHA_RS04035	COG1138	Cytochrome C-type biogenesis protein
PSHA_RS04055	COG2853	Lipoprotein
PSHA_RS04060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PSHA_RS04065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PSHA_RS04070	COG3141	response to X-ray
PSHA_RS04075	COG1555	photosystem II stabilization
PSHA_RS04085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PSHA_RS04095	COG0450	alkyl hydroperoxide reductase
PSHA_RS04100	COG4206	TonB-dependent receptor
PSHA_RS04105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PSHA_RS04110	COG2867	negative regulation of translational initiation
PSHA_RS04115	COG2914	Belongs to the UPF0125 (RnfH) family
PSHA_RS04120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PSHA_RS04145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PSHA_RS04150	COG0583	DNA-binding transcription factor activity
PSHA_RS04165	COG0745	RESPONSE REGULATOR receiver
PSHA_RS04170	COG2205	protein histidine kinase activity
PSHA_RS04185	COG4326	sporulation control protein
PSHA_RS04190	COG2153	protein acetylation
PSHA_RS04195	COG0733	neurotransmitter:sodium symporter activity
PSHA_RS04200	COG2205	protein histidine kinase activity
PSHA_RS04205	COG0745	RESPONSE REGULATOR receiver
PSHA_RS04235	COG1534	Rna-binding protein
PSHA_RS04240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PSHA_RS04245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PSHA_RS04250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PSHA_RS04255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PSHA_RS04260	COG0149	triose-phosphate isomerase activity
PSHA_RS04265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PSHA_RS04275	COG4221	oxidoreductase activity
PSHA_RS04280	COG4771	TonB-dependent receptor
PSHA_RS04300	COG1902	pentaerythritol trinitrate reductase activity
PSHA_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS04340	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS04345	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS04365	COG0596	Alpha beta hydrolase
PSHA_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS04380	COG0318	PFAM AMP-dependent synthetase and ligase
PSHA_RS04395	COG0346	lactoylglutathione lyase activity
PSHA_RS04410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PSHA_RS04415	COG2070	2-Nitropropane dioxygenase
PSHA_RS04425	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS04430	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS04435	COG0183	Belongs to the thiolase family
PSHA_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS04460	COG2201	protein-glutamate methylesterase activity
PSHA_RS04465	COG0268	Binds directly to 16S ribosomal RNA
PSHA_RS04470	COG0728	peptidoglycan biosynthetic process
PSHA_RS04475	COG0196	riboflavin kinase activity
PSHA_RS04480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PSHA_RS04485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PSHA_RS04490	COG1047	Peptidyl-prolyl cis-trans
PSHA_RS04495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PSHA_RS04500	COG2972	Histidine kinase
PSHA_RS04500	COG0745	RESPONSE REGULATOR receiver
PSHA_RS04550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PSHA_RS04555	COG0564	pseudouridine synthase activity
PSHA_RS04565	COG0542	response to heat
PSHA_RS04570	COG0840	transmembrane signaling receptor activity
PSHA_RS04575	COG2918	glutathione biosynthetic process
PSHA_RS04585	COG4536	flavin adenine dinucleotide binding
PSHA_RS04590	COG4137	Cytochrome C assembly protein
PSHA_RS04595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PSHA_RS04600	COG0228	four-way junction DNA binding
PSHA_RS04605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PSHA_RS04610	COG0336	Belongs to the RNA methyltransferase TrmD family
PSHA_RS04615	COG0335	large ribosomal subunit rRNA binding
PSHA_RS04620	COG0668	transmembrane transport
PSHA_RS04625	COG0287	Prephenate dehydrogenase
PSHA_RS04625	COG1605	Chorismate mutase
PSHA_RS04630	COG0077	Prephenate dehydratase
PSHA_RS04630	COG1605	Chorismate mutase
PSHA_RS04640	COG0023	Translation Initiation Factor
PSHA_RS04660	COG1448	Aminotransferase
PSHA_RS04675	COG1595	DNA-templated transcription, initiation
PSHA_RS04685	COG2304	oxidoreductase activity
PSHA_RS04690	COG2304	oxidoreductase activity
PSHA_RS04705	COG0714	Associated with various cellular activities
PSHA_RS04710	COG0183	Belongs to the thiolase family
PSHA_RS04715	COG1250	3-hydroxyacyl-CoA dehydrogenase
PSHA_RS04715	COG1024	Enoyl-CoA hydratase
PSHA_RS04720	COG2315	Protein conserved in bacteria
PSHA_RS04725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PSHA_RS04735	COG5001	Diguanylate cyclase
PSHA_RS04735	COG3300	MHYT domain
PSHA_RS04740	COG1025	Belongs to the peptidase M16 family
PSHA_RS04745	COG2062	phosphohistidine phosphatase, SixA
PSHA_RS04770	COG1620	l-lactate permease
PSHA_RS04775	COG0583	DNA-binding transcription factor activity
PSHA_RS04785	COG2840	Smr protein MutS2
PSHA_RS04790	COG2890	protein-(glutamine-N5) methyltransferase activity
PSHA_RS04795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PSHA_RS04810	COG3101	peptidyl-lysine hydroxylation
PSHA_RS04825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PSHA_RS04845	COG0071	Belongs to the small heat shock protein (HSP20) family
PSHA_RS04850	COG3046	protein related to deoxyribodipyrimidine photolyase
PSHA_RS04860	COG0779	Required for maturation of 30S ribosomal subunits
PSHA_RS04865	COG0195	Participates in both transcription termination and antitermination
PSHA_RS04870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PSHA_RS04875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PSHA_RS04880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PSHA_RS04885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PSHA_RS04890	COG1185	polyribonucleotide nucleotidyltransferase activity
PSHA_RS04905	COG2111	Na H antiporter
PSHA_RS04905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PSHA_RS04910	COG1006	Multisubunit Na H antiporter MnhC subunit
PSHA_RS04915	COG0651	ATP synthesis coupled electron transport
PSHA_RS04920	COG1863	multisubunit Na H antiporter MnhE subunit
PSHA_RS04925	COG2212	antiporter activity
PSHA_RS04930	COG1320	monovalent cation:proton antiporter activity
PSHA_RS04940	COG2217	Heavy metal translocating P-type atpase
PSHA_RS04975	COG0724	RNA recognition motif
PSHA_RS04980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PSHA_RS04985	COG0321	lipoyl(octanoyl) transferase activity
PSHA_RS04990	COG2921	Belongs to the UPF0250 family
PSHA_RS04995	COG1686	Belongs to the peptidase S11 family
PSHA_RS05000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PSHA_RS05005	COG0772	Belongs to the SEDS family
PSHA_RS05010	COG0768	penicillin binding
PSHA_RS05015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PSHA_RS05020	COG0799	negative regulation of ribosome biogenesis
PSHA_RS05025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PSHA_RS05035	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
PSHA_RS05040	COG0495	leucyl-tRNA aminoacylation
PSHA_RS05045	COG2888	peptidyl-tyrosine sulfation
PSHA_RS05050	COG1067	ATP-dependent peptidase activity
PSHA_RS05055	COG0545	Peptidyl-prolyl cis-trans isomerase
PSHA_RS05075	COG4946	Tricorn protease homolog
PSHA_RS05075	COG0793	Belongs to the peptidase S41A family
PSHA_RS05095	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PSHA_RS05100	COG4535	Mg2 and Co2 transporter CorC
PSHA_RS05105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PSHA_RS05110	COG1702	phosphate starvation-inducible protein PhoH
PSHA_RS05115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PSHA_RS05120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PSHA_RS05175	COG0012	GTP binding
PSHA_RS05180	COG0193	aminoacyl-tRNA hydrolase activity
PSHA_RS05185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PSHA_RS05190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PSHA_RS05195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PSHA_RS05200	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PSHA_RS05205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PSHA_RS05210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PSHA_RS05215	COG2890	protein-(glutamine-N5) methyltransferase activity
PSHA_RS05235	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PSHA_RS05240	COG0583	DNA-binding transcription factor activity
PSHA_RS05250	COG2363	Small membrane protein
PSHA_RS05255	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PSHA_RS05260	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PSHA_RS05270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PSHA_RS05280	COG1166	arginine decarboxylase activity
PSHA_RS05295	COG1566	PFAM secretion protein HlyD family protein
PSHA_RS05300	COG1289	transmembrane transporter activity
PSHA_RS05305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSHA_RS05310	COG1196	nuclear chromosome segregation
PSHA_RS05315	COG3115	cell septum assembly
PSHA_RS05320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PSHA_RS05340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSHA_RS05425	COG0612	Peptidase, M16
PSHA_RS05430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PSHA_RS05435	COG0346	lactoylglutathione lyase activity
PSHA_RS05445	COG1982	Orn Lys Arg decarboxylase major
PSHA_RS05460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PSHA_RS05465	COG4660	Part of a membrane complex involved in electron transport
PSHA_RS05470	COG4659	FMN binding
PSHA_RS05475	COG4658	electron transport chain
PSHA_RS05490	COG4657	Part of a membrane complex involved in electron transport
PSHA_RS05495	COG2200	EAL domain
PSHA_RS05495	COG2203	Gaf domain
PSHA_RS05495	COG2199	diguanylate cyclase activity
PSHA_RS05520	COG0534	Mate efflux family protein
PSHA_RS05525	COG0556	nucleotide-excision repair
PSHA_RS05530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PSHA_RS05550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PSHA_RS05555	COG0602	queuosine metabolic process
PSHA_RS05560	COG2226	methyltransferase
PSHA_RS05575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PSHA_RS05580	COG2716	regulation of RNA biosynthetic process
PSHA_RS05590	COG3314	Sporulation integral membrane protein YlbJ
PSHA_RS05595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PSHA_RS05600	COG2854	intermembrane phospholipid transfer
PSHA_RS05620	COG1393	Belongs to the ArsC family
PSHA_RS05625	COG4783	chaperone-mediated protein folding
PSHA_RS05645	COG1104	cysteine desulfurase activity
PSHA_RS05650	COG0166	Belongs to the GPI family
PSHA_RS05655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PSHA_RS05660	COG0363	glucosamine-6-phosphate deaminase activity
PSHA_RS05675	COG1643	Atp-dependent helicase
PSHA_RS05690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PSHA_RS05695	COG1418	mRNA catabolic process
PSHA_RS05705	COG3437	response regulator, receiver
PSHA_RS05710	COG2205	protein histidine kinase activity
PSHA_RS05710	COG2198	Histidine kinase
PSHA_RS05710	COG0784	Response regulator, receiver
PSHA_RS05740	COG4251	negative regulation of phosphorylation
PSHA_RS05740	COG2203	Gaf domain
PSHA_RS05740	COG3706	GGDEF domain
PSHA_RS05740	COG5001	Diguanylate cyclase
PSHA_RS05745	COG3012	SEC-C Motif Domain Protein
PSHA_RS05755	COG2252	PERMEase
PSHA_RS05765	COG0583	DNA-binding transcription factor activity
PSHA_RS05770	COG1760	l-serine dehydratase
PSHA_RS05775	COG0494	nUDIX hydrolase
PSHA_RS05780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PSHA_RS05800	COG3706	GGDEF domain
PSHA_RS05805	COG3228	Belongs to the MtfA family
PSHA_RS05810	COG1228	amidohydrolase
PSHA_RS05820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PSHA_RS05825	COG1742	UPF0060 membrane protein
PSHA_RS05840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PSHA_RS05845	COG0583	DNA-binding transcription factor activity
PSHA_RS05855	COG0418	dihydroorotase activity
PSHA_RS05860	COG1278	Cold shock
PSHA_RS05870	COG0811	peptide transport
PSHA_RS05875	COG0811	peptide transport
PSHA_RS05880	COG0848	biopolymer transport protein
PSHA_RS05905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PSHA_RS05915	COG3220	belongs to the UPF0276 family
PSHA_RS05920	COG3219	Protein conserved in bacteria
PSHA_RS05925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PSHA_RS05930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PSHA_RS05935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PSHA_RS05940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PSHA_RS05950	COG0564	pseudouridine synthase activity
PSHA_RS05955	COG0326	Molecular chaperone. Has ATPase activity
PSHA_RS05960	COG0563	adenylate kinase activity
PSHA_RS05965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PSHA_RS05970	COG2201	protein-glutamate methylesterase activity
PSHA_RS05975	COG3706	GGDEF domain
PSHA_RS05980	COG2719	SpoVR family
PSHA_RS05985	COG2718	Belongs to the UPF0229 family
PSHA_RS05990	COG2766	serine protein kinase
PSHA_RS05995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PSHA_RS06000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PSHA_RS06010	COG0497	DNA recombination
PSHA_RS06020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PSHA_RS06025	COG1420	regulation of RNA biosynthetic process
PSHA_RS06030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PSHA_RS06035	COG2814	Major facilitator Superfamily
PSHA_RS06055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PSHA_RS06060	COG0505	Belongs to the CarA family
PSHA_RS06065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PSHA_RS06075	COG2239	Acts as a magnesium transporter
PSHA_RS06085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PSHA_RS06095	COG0583	DNA-binding transcription factor activity
PSHA_RS06105	COG0564	pseudouridine synthase activity
PSHA_RS06115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSHA_RS06160	COG0527	aspartate kinase activity
PSHA_RS06170	COG0733	neurotransmitter:sodium symporter activity
PSHA_RS06175	COG0386	Belongs to the glutathione peroxidase family
PSHA_RS06180	COG2084	Dehydrogenase
PSHA_RS06185	COG2925	Exonuclease
PSHA_RS06205	COG0477	Major facilitator Superfamily
PSHA_RS06215	COG0583	DNA-binding transcription factor activity
PSHA_RS06230	COG0300	oxidoreductase activity
PSHA_RS06235	COG3647	Membrane
PSHA_RS06250	COG0543	2 iron, 2 sulfur cluster binding
PSHA_RS06250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PSHA_RS06275	COG1505	serine-type exopeptidase activity
PSHA_RS06280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PSHA_RS06295	COG3706	GGDEF domain
PSHA_RS06300	COG1090	epimerase
PSHA_RS06305	COG0628	permease
PSHA_RS06335	COG2350	Protein conserved in bacteria
PSHA_RS06340	COG0733	neurotransmitter:sodium symporter activity
PSHA_RS06360	COG0135	phosphoribosylanthranilate isomerase activity
PSHA_RS06360	COG0134	indole-3-glycerol-phosphate synthase activity
PSHA_RS06365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PSHA_RS06370	COG0512	Glutamine amidotransferase of anthranilate synthase
PSHA_RS06375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PSHA_RS06380	COG0613	PHP domain protein
PSHA_RS06385	COG0009	L-threonylcarbamoyladenylate synthase
PSHA_RS06395	COG3038	cytochrome b561
PSHA_RS06400	COG2353	YceI-like domain
PSHA_RS06435	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PSHA_RS06465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PSHA_RS06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PSHA_RS06485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PSHA_RS06490	COG0489	protein tyrosine kinase activity
PSHA_RS06495	COG0717	Belongs to the dCTP deaminase family
PSHA_RS06515	COG0436	Aminotransferase
PSHA_RS06525	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
PSHA_RS06545	COG1876	peptidase activity
PSHA_RS06550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PSHA_RS06555	COG1393	Belongs to the ArsC family
PSHA_RS06565	COG3092	negative regulation of chromosome organization
PSHA_RS06570	COG2226	methyltransferase
PSHA_RS06590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PSHA_RS06595	COG1187	pseudouridine synthase activity
PSHA_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS06605	COG2267	carboxylic ester hydrolase activity
PSHA_RS06610	COG0616	signal peptide processing
PSHA_RS06615	COG1301	dicarboxylic acid transport
PSHA_RS06635	COG2862	Uncharacterized protein family, UPF0114
PSHA_RS06640	COG0366	Alpha amylase catalytic
PSHA_RS06655	COG0366	Alpha amylase catalytic
PSHA_RS06695	COG2860	membrane
PSHA_RS06700	COG1609	Transcriptional regulator
PSHA_RS06705	COG0837	glucose binding
PSHA_RS06710	COG1609	Transcriptional regulator
PSHA_RS06735	COG0217	transcriptional regulatory protein
PSHA_RS06740	COG3590	peptidase
PSHA_RS06745	COG5265	(ABC) transporter
PSHA_RS06755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PSHA_RS06760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PSHA_RS06770	COG0189	ligase activity
PSHA_RS06775	COG1214	PFAM Peptidase M22, glycoprotease
PSHA_RS06775	COG0456	acetyltransferase
PSHA_RS06780	COG1285	pathogenesis
PSHA_RS06785	COG5001	Diguanylate cyclase
PSHA_RS06785	COG3300	MHYT domain
PSHA_RS06800	COG1285	pathogenesis
PSHA_RS06820	COG0583	DNA-binding transcription factor activity
PSHA_RS06825	COG4591	ABC-type transport system involved in lipoprotein release permease component
PSHA_RS06830	COG1136	(ABC) transporter
PSHA_RS06835	COG4591	ABC-type transport system involved in lipoprotein release permease component
PSHA_RS06845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PSHA_RS06850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PSHA_RS06855	COG0318	PFAM AMP-dependent synthetase and ligase
PSHA_RS06870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PSHA_RS06875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PSHA_RS06880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PSHA_RS06890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PSHA_RS06895	COG1522	sequence-specific DNA binding
PSHA_RS06900	COG0659	secondary active sulfate transmembrane transporter activity
PSHA_RS06905	COG2972	Histidine kinase
PSHA_RS06910	COG3279	Response regulator of the LytR AlgR family
PSHA_RS06915	COG0469	pyruvate kinase activity
PSHA_RS06920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PSHA_RS06925	COG0252	asparaginase activity
PSHA_RS06930	COG0616	signal peptide processing
PSHA_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
PSHA_RS06935	COG1902	pentaerythritol trinitrate reductase activity
PSHA_RS06940	COG0778	Nitroreductase
PSHA_RS06960	COG0545	Peptidyl-prolyl cis-trans isomerase
PSHA_RS06970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PSHA_RS06980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PSHA_RS06990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PSHA_RS07000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PSHA_RS07005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PSHA_RS07010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PSHA_RS07015	COG0539	negative regulation of cytoplasmic translation
PSHA_RS07020	COG0776	regulation of translation
PSHA_RS07030	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PSHA_RS07035	COG0284	orotidine-5'-phosphate decarboxylase activity
PSHA_RS07050	COG0513	Belongs to the DEAD box helicase family
PSHA_RS07055	COG1054	Belongs to the UPF0176 family
PSHA_RS07060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PSHA_RS07060	COG0517	IMP dehydrogenase activity
PSHA_RS07065	COG2176	DNA-directed DNA polymerase activity
PSHA_RS07070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PSHA_RS07080	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PSHA_RS07090	COG0367	asparagine synthase
PSHA_RS07095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PSHA_RS07100	COG1984	allophanate hydrolase subunit 2
PSHA_RS07110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSHA_RS07110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSHA_RS07115	COG0583	DNA-binding transcription factor activity
PSHA_RS07125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PSHA_RS07135	COG4770	biotin carboxylase activity
PSHA_RS07145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PSHA_RS07150	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS07160	COG0183	Belongs to the thiolase family
PSHA_RS07175	COG1024	Enoyl-CoA hydratase
PSHA_RS07180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PSHA_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS07230	COG0583	DNA-binding transcription factor activity
PSHA_RS07235	COG0730	response to heat
PSHA_RS07290	COG3038	cytochrome b561
PSHA_RS07305	COG2314	TM2 domain
PSHA_RS07310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PSHA_RS07325	COG4628	conserved protein (DUF2132)
PSHA_RS07330	COG0604	alcohol dehydrogenase
PSHA_RS07335	COG1309	transcriptional regulator
PSHA_RS07340	COG3130	regulation of translation
PSHA_RS07345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PSHA_RS07360	COG1607	acyl-coa hydrolase
PSHA_RS07365	COG2056	Na+-H+ antiporter family
PSHA_RS07380	COG0714	Associated with various cellular activities
PSHA_RS07670	COG3788	relative of glutathione S-transferase, MAPEG superfamily
PSHA_RS07685	COG0281	malic enzyme
PSHA_RS07690	COG0405	Gamma-glutamyltransferase
PSHA_RS07710	COG2855	membrane
PSHA_RS07720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PSHA_RS07725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PSHA_RS07730	COG0488	(ABC) transporter
PSHA_RS07760	COG1309	transcriptional regulator
PSHA_RS07765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSHA_RS07780	COG0183	Belongs to the thiolase family
PSHA_RS07785	COG2207	Transcriptional regulator
PSHA_RS07795	COG1012	belongs to the aldehyde dehydrogenase family
PSHA_RS07840	COG1192	Involved in chromosome partitioning
PSHA_RS07870	COG0501	Belongs to the peptidase M48B family
PSHA_RS07875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PSHA_RS07880	COG2226	methyltransferase
PSHA_RS07890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PSHA_RS07910	COG1178	ABC-type Fe3 transport system permease component
PSHA_RS07915	COG3842	ATPase activity
PSHA_RS07925	COG0017	Asparaginyl-tRNA synthetase
PSHA_RS07955	COG1720	tRNA m6t6A37 methyltransferase activity
PSHA_RS07960	COG0442	prolyl-tRNA aminoacylation
PSHA_RS07970	COG1668	transmembrane transport
PSHA_RS07975	COG4555	ABC transporter
PSHA_RS08000	COG0022	dehydrogenase e1 component
PSHA_RS08010	COG2988	succinylglutamate desuccinylase activity
PSHA_RS08015	COG0033	Phosphoglucomutase
PSHA_RS08020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PSHA_RS08025	COG0596	Alpha beta hydrolase
PSHA_RS08050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PSHA_RS08060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PSHA_RS08065	COG0045	succinate-CoA ligase (ADP-forming) activity
PSHA_RS08070	COG0508	dehydrogenase complex catalyzes the overall conversion of
PSHA_RS08075	COG0567	Dehydrogenase, E1 component
PSHA_RS08085	COG1053	succinate dehydrogenase
PSHA_RS08090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PSHA_RS08110	COG2166	iron-sulfur cluster assembly
PSHA_RS08115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PSHA_RS08120	COG0564	pseudouridine synthase activity
PSHA_RS08125	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PSHA_RS08130	COG2835	tetraacyldisaccharide 4'-kinase activity
PSHA_RS08135	COG1663	tetraacyldisaccharide 4'-kinase activity
PSHA_RS08140	COG1132	(ABC) transporter
PSHA_RS08145	COG2333	competence protein COMEC
PSHA_RS08145	COG0658	competence protein
PSHA_RS08160	COG0488	(ABC) transporter
PSHA_RS08170	COG0116	Belongs to the methyltransferase superfamily
PSHA_RS08170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PSHA_RS08180	COG0167	dihydroorotate dehydrogenase activity
PSHA_RS08185	COG2902	Dehydrogenase
PSHA_RS08210	COG0308	aminopeptidase N
PSHA_RS08215	COG1757	Na H antiporter
PSHA_RS08225	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PSHA_RS08235	COG1956	GAF domain-containing protein
PSHA_RS08255	COG0670	Belongs to the BI1 family
PSHA_RS08265	COG2923	Belongs to the DsrF TusC family
PSHA_RS08275	COG2920	part of a sulfur-relay system
PSHA_RS08280	COG1187	pseudouridine synthase activity
PSHA_RS08285	COG2203	Gaf domain
PSHA_RS08285	COG3706	GGDEF domain
PSHA_RS08285	COG4251	negative regulation of phosphorylation
PSHA_RS08285	COG5001	Diguanylate cyclase
PSHA_RS08290	COG0482	sulfurtransferase activity
PSHA_RS08295	COG2915	High frequency lysogenization protein hflD homolog
PSHA_RS08300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PSHA_RS08305	COG2850	peptidyl-arginine hydroxylation
PSHA_RS08320	COG2234	aminopeptidase activity
PSHA_RS08325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PSHA_RS08330	COG1132	(ABC) transporter
PSHA_RS08355	COG3977	Valine--pyruvate aminotransferase
PSHA_RS08365	COG1914	H( )-stimulated, divalent metal cation uptake system
PSHA_RS08375	COG2133	pyrroloquinoline quinone binding
PSHA_RS08395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PSHA_RS08400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PSHA_RS08405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PSHA_RS08410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PSHA_RS08415	COG0531	amino acid
PSHA_RS08415	COG1674	ftsk spoiiie
PSHA_RS08425	COG0686	Belongs to the AlaDH PNT family
PSHA_RS08430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PSHA_RS08435	COG0492	ferredoxin-NADP+ reductase activity
PSHA_RS08440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PSHA_RS08445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PSHA_RS08450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PSHA_RS08455	COG0542	response to heat
PSHA_RS08460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PSHA_RS08465	COG1278	Cold shock
PSHA_RS08480	COG1228	amidohydrolase
PSHA_RS08495	COG3001	Fructosamine kinase
PSHA_RS08505	COG0307	riboflavin synthase, alpha
PSHA_RS08530	COG0753	catalase activity
PSHA_RS08550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PSHA_RS08560	COG0800	Aldolase
PSHA_RS08565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PSHA_RS08570	COG2271	Major facilitator Superfamily
PSHA_RS08575	COG1917	Cupin 2, conserved barrel domain protein
PSHA_RS08605	COG1741	Belongs to the pirin family
PSHA_RS08610	COG0583	DNA-binding transcription factor activity
PSHA_RS08615	COG1741	Belongs to the pirin family
PSHA_RS08620	COG0829	nickel cation binding
PSHA_RS08625	COG0831	urea catabolic process
PSHA_RS08630	COG0832	Belongs to the urease beta subunit family
PSHA_RS08635	COG0804	urea catabolic process
PSHA_RS08640	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PSHA_RS08645	COG0830	nickel cation binding
PSHA_RS08650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PSHA_RS08665	COG2079	MmgE PrpD family protein
PSHA_RS08675	COG2017	converts alpha-aldose to the beta-anomer
PSHA_RS08695	COG1609	Transcriptional regulator
PSHA_RS08700	COG2828	Protein conserved in bacteria
PSHA_RS08705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PSHA_RS08710	COG0372	Belongs to the citrate synthase family
PSHA_RS08715	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PSHA_RS08725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PSHA_RS08725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PSHA_RS08740	COG3206	protein involved in exopolysaccharide biosynthesis
PSHA_RS08740	COG0489	protein tyrosine kinase activity
PSHA_RS08755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PSHA_RS08780	COG0463	Glycosyl transferase, family 2
PSHA_RS08780	COG1216	Glycosyl transferase, family 2
PSHA_RS08805	COG2203	Gaf domain
PSHA_RS08805	COG2200	EAL domain
PSHA_RS08805	COG2199	diguanylate cyclase activity
PSHA_RS08825	COG0084	hydrolase, TatD family'
PSHA_RS08835	COG0470	DNA polymerase III
PSHA_RS08840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PSHA_RS08845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PSHA_RS08850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PSHA_RS08855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PSHA_RS08860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PSHA_RS08870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PSHA_RS08875	COG0416	fatty acid biosynthetic process
PSHA_RS08880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PSHA_RS08885	COG1399	metal-binding, possibly nucleic acid-binding protein
PSHA_RS08890	COG0424	maF-like protein
PSHA_RS08895	COG0546	phosphoglycolate phosphatase activity
PSHA_RS08900	COG0564	pseudouridine synthase activity
PSHA_RS08905	COG1530	ribonuclease E activity
PSHA_RS08910	COG3081	Nucleoid-associated protein
PSHA_RS08915	COG3082	Protein of unknown function (DUF1414)
PSHA_RS08920	COG3083	sulfuric ester hydrolase activity
PSHA_RS08930	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PSHA_RS08965	COG3258	Cytochrome c
PSHA_RS08975	COG0583	DNA-binding transcription factor activity
PSHA_RS08980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PSHA_RS08995	COG2957	Belongs to the agmatine deiminase family
PSHA_RS09000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PSHA_RS09005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PSHA_RS09035	COG3278	Belongs to the heme-copper respiratory oxidase family
PSHA_RS09050	COG2010	Cytochrome c
PSHA_RS09060	COG2217	Heavy metal translocating P-type atpase
PSHA_RS09075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PSHA_RS09085	COG0037	tRNA processing
PSHA_RS09090	COG1335	isochorismatase
PSHA_RS09100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PSHA_RS09105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PSHA_RS09110	COG1074	ATP-dependent DNA helicase activity
PSHA_RS09115	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PSHA_RS09145	COG3258	Cytochrome c
PSHA_RS09155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PSHA_RS09200	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PSHA_RS09205	COG2885	chlorophyll binding
PSHA_RS09210	COG0823	Involved in the tonB-independent uptake of proteins
PSHA_RS09225	COG0811	peptide transport
PSHA_RS09230	COG2255	four-way junction helicase activity
PSHA_RS09235	COG0632	four-way junction helicase activity
PSHA_RS09240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PSHA_RS09245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PSHA_RS09250	COG4181	ATPase activity
PSHA_RS09255	COG2755	lipolytic protein G-D-S-L family
PSHA_RS09270	COG0393	Putative heavy-metal-binding
PSHA_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS09310	COG0210	DNA helicase
PSHA_RS09325	COG3604	Transcriptional regulator
PSHA_RS09340	COG3139	Protein of unknown function (DUF1315)
PSHA_RS09350	COG1115	amino acid carrier protein
PSHA_RS09355	COG2866	Carboxypeptidase
PSHA_RS09370	COG0776	regulation of translation
PSHA_RS09375	COG0072	phenylalanine-tRNA ligase activity
PSHA_RS09380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PSHA_RS09410	COG1115	amino acid carrier protein
PSHA_RS09460	COG0322	excinuclease ABC activity
PSHA_RS09465	COG2197	response regulator
PSHA_RS09470	COG1823	symporter activity
PSHA_RS09475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PSHA_RS09510	COG0626	cystathionine gamma-synthase activity
PSHA_RS09535	COG0513	Belongs to the DEAD box helicase family
PSHA_RS09570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PSHA_RS09575	COG1801	Protein of unknown function DUF72
PSHA_RS09580	COG1451	nucleotide metabolic process
PSHA_RS09590	COG0583	DNA-binding transcription factor activity
PSHA_RS09595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PSHA_RS09605	COG2226	methyltransferase
PSHA_RS09610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PSHA_RS09615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PSHA_RS09620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PSHA_RS09635	COG0121	glutamine amidotransferase
PSHA_RS09640	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS09715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PSHA_RS09720	COG0328	RNA-DNA hybrid ribonuclease activity
PSHA_RS09725	COG2226	methyltransferase
PSHA_RS09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PSHA_RS09735	COG0741	lytic transglycosylase activity
PSHA_RS09735	COG1388	LysM domain
PSHA_RS09745	COG0716	FMN binding
PSHA_RS09750	COG0564	pseudouridine synthase activity
PSHA_RS09755	COG3098	single-species biofilm formation
PSHA_RS09785	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PSHA_RS09795	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PSHA_RS09795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PSHA_RS09805	COG2911	Protein conserved in bacteria
PSHA_RS09820	COG1061	Type III restriction enzyme res subunit
PSHA_RS09830	COG4771	TonB-dependent receptor
PSHA_RS09845	COG0417	DNA replication proofreading
PSHA_RS09850	COG1199	ATP-dependent helicase activity
PSHA_RS09855	COG0730	response to heat
PSHA_RS09875	COG0477	Major facilitator Superfamily
PSHA_RS09885	COG2391	methyltransferase activity
PSHA_RS09895	COG0427	acetyl-CoA hydrolase
PSHA_RS09945	COG0037	tRNA processing
PSHA_RS09950	COG0825	malonyl-CoA metabolic process
PSHA_RS09955	COG0587	DNA-directed DNA polymerase activity
PSHA_RS09960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PSHA_RS09965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PSHA_RS09975	COG1294	oxidase, subunit
PSHA_RS09980	COG4890	Cyd operon protein YbgT
PSHA_RS09985	COG4988	ABC transporter
PSHA_RS09990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PSHA_RS09995	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PSHA_RS10000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PSHA_RS10005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PSHA_RS10010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PSHA_RS10025	COG0750	zinc metalloprotease
PSHA_RS10030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PSHA_RS10040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PSHA_RS10045	COG0233	cytoplasmic translational termination
PSHA_RS10050	COG0528	UMP kinase activity
PSHA_RS10055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PSHA_RS10060	COG0052	Belongs to the universal ribosomal protein uS2 family
PSHA_RS10065	COG0024	Methionine aminopeptidase
PSHA_RS10070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PSHA_RS10075	COG2171	N-acyltransferase activity
PSHA_RS10085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PSHA_RS10090	COG2154	pterin-4-alpha-carbinolamine dehydratase
PSHA_RS10100	COG0626	cystathionine gamma-synthase activity
PSHA_RS10105	COG3768	UPF0283 membrane protein
PSHA_RS10110	COG3106	COG3106 Predicted ATPase
PSHA_RS10115	COG1983	PspC domain protein
PSHA_RS10125	COG1842	Phage shock protein A
PSHA_RS10130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PSHA_RS10135	COG0747	negative chemotaxis
PSHA_RS10145	COG4171	peptide transport system, permease
PSHA_RS10155	COG4172	Belongs to the ABC transporter superfamily
PSHA_RS10165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSHA_RS10175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PSHA_RS10180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PSHA_RS10185	COG0740	serine-type endopeptidase activity
PSHA_RS10190	COG0544	peptidyl-prolyl cis-trans isomerase activity
PSHA_RS10220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PSHA_RS10225	COG0215	cysteine-tRNA ligase activity
PSHA_RS10230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PSHA_RS10250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PSHA_RS10255	COG1286	toxin biosynthetic process
PSHA_RS10265	COG0285	dihydrofolate synthase activity
PSHA_RS10270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PSHA_RS10275	COG0101	tRNA pseudouridine synthase activity
PSHA_RS10290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PSHA_RS10295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PSHA_RS10300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PSHA_RS10300	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PSHA_RS10305	COG0702	epimerase
PSHA_RS10315	COG0786	glutamate:sodium symporter activity
PSHA_RS10345	COG0732	type I restriction modification DNA specificity domain
PSHA_RS10350	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PSHA_RS10420	COG4974	Belongs to the 'phage' integrase family
PSHA_RS10435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PSHA_RS10440	COG2885	chlorophyll binding
PSHA_RS10450	COG0814	amino acid
PSHA_RS10465	COG2197	response regulator
PSHA_RS10500	COG0183	Belongs to the thiolase family
PSHA_RS10510	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS10515	COG1960	acyl-CoA dehydrogenase activity
PSHA_RS10525	COG1053	succinate dehydrogenase
PSHA_RS10550	COG4771	TonB-dependent receptor
PSHA_RS10555	COG1012	belongs to the aldehyde dehydrogenase family
PSHA_RS10560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PSHA_RS10570	COG4569	acetaldehyde dehydrogenase (acetylating) activity
PSHA_RS10575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PSHA_RS10580	COG2271	Major facilitator Superfamily
PSHA_RS10600	COG0235	Class ii aldolase
PSHA_RS10625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PSHA_RS10630	COG0534	Mate efflux family protein
PSHA_RS10635	COG3047	cAMP biosynthetic process
PSHA_RS10650	COG2194	sulfuric ester hydrolase activity
PSHA_RS10670	COG1215	transferase activity, transferring glycosyl groups
PSHA_RS10680	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PSHA_RS10685	COG0457	Tetratricopeptide repeat
PSHA_RS10705	COG0179	Fumarylacetoacetate (FAA) hydrolase
PSHA_RS10710	COG0739	heme binding
PSHA_RS10735	COG1803	Methylglyoxal synthase
PSHA_RS10740	COG0443	Heat shock 70 kDa protein
PSHA_RS10745	COG1793	dna ligase
PSHA_RS10750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PSHA_RS10760	COG4771	TonB-dependent receptor
PSHA_RS10770	COG1196	nuclear chromosome segregation
PSHA_RS10770	COG3264	Mechanosensitive ion channel
PSHA_RS10780	COG0339	signal peptide processing
PSHA_RS10785	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PSHA_RS10805	COG0583	DNA-binding transcription factor activity
PSHA_RS10820	COG0625	glutathione transferase activity
PSHA_RS10835	COG0745	RESPONSE REGULATOR receiver
PSHA_RS10840	COG2205	protein histidine kinase activity
PSHA_RS10855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PSHA_RS10860	COG0415	Belongs to the DNA photolyase family
PSHA_RS10865	COG1764	response to oxidative stress
PSHA_RS10890	COG2814	Major facilitator Superfamily
PSHA_RS10895	COG1064	alcohol dehydrogenase
PSHA_RS10930	COG0583	DNA-binding transcription factor activity
PSHA_RS10935	COG1643	Atp-dependent helicase
PSHA_RS10945	COG3237	CsbD-like
PSHA_RS10970	COG0646	methionine synthase
PSHA_RS10970	COG1410	methionine synthase
PSHA_RS10975	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PSHA_RS10980	COG0488	(ABC) transporter
PSHA_RS10985	COG0123	including yeast histone deacetylase and acetoin utilization protein
PSHA_RS10990	COG0109	protoheme IX farnesyltransferase activity
PSHA_RS11010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PSHA_RS11025	COG1477	protein flavinylation
PSHA_RS11030	COG2871	sodium ion transport
PSHA_RS11035	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSHA_RS11040	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSHA_RS11045	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSHA_RS11050	COG1805	sodium ion transport
PSHA_RS11055	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSHA_RS11060	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PSHA_RS11065	COG0271	Belongs to the BolA IbaG family
PSHA_RS11075	COG2813	Specifically methylates the guanine in position
PSHA_RS11090	COG2211	Major facilitator Superfamily
PSHA_RS11105	COG0316	Belongs to the HesB IscA family
PSHA_RS11115	COG1981	membrane
PSHA_RS11120	COG0540	Belongs to the ATCase OTCase family
PSHA_RS11125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PSHA_RS11130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PSHA_RS11135	COG0004	ammonium transporteR
PSHA_RS11155	COG3025	triphosphatase activity
PSHA_RS11160	COG4991	sh3 domain protein
PSHA_RS11170	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PSHA_RS11170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PSHA_RS11170	COG0506	proline dehydrogenase activity
PSHA_RS11185	COG3267	Type II secretory pathway component ExeA
PSHA_RS11185	COG3409	Peptidoglycan-binding domain 1 protein
PSHA_RS11215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSHA_RS11225	COG4206	TonB-dependent receptor
PSHA_RS11230	COG1666	GTP binding
PSHA_RS11240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PSHA_RS11245	COG0301	tRNA thio-modification
PSHA_RS11245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PSHA_RS11255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PSHA_RS11280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PSHA_RS11280	COG0165	Argininosuccinate lyase
PSHA_RS11285	COG0137	argininosuccinate synthase activity
PSHA_RS11300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PSHA_RS11310	COG0076	glutamate decarboxylase activity
PSHA_RS11320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PSHA_RS11325	COG0842	Transport permease protein
PSHA_RS11330	COG1131	(ABC) transporter
PSHA_RS11335	COG0163	prenyltransferase activity
PSHA_RS11340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PSHA_RS11345	COG1968	undecaprenyl-diphosphatase activity
PSHA_RS11355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PSHA_RS11360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PSHA_RS11365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PSHA_RS11385	COG0583	DNA-binding transcription factor activity
PSHA_RS11395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PSHA_RS11400	COG3161	chorismate lyase activity
PSHA_RS11405	COG1580	Controls the rotational direction of flagella during chemotaxis
PSHA_RS11410	COG0705	Rhomboid family
PSHA_RS11415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PSHA_RS11420	COG1063	alcohol dehydrogenase
PSHA_RS11430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PSHA_RS11435	COG0859	PFAM glycosyl transferase family 9
PSHA_RS11440	COG3642	lipopolysaccharide core region biosynthetic process
PSHA_RS11460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PSHA_RS11460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PSHA_RS11465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PSHA_RS11470	COG1519	Transferase
PSHA_RS11480	COG3784	Protein of unknown function (DUF1318)
PSHA_RS11495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PSHA_RS11495	COG0047	phosphoribosylformylglycinamidine synthase activity
PSHA_RS11500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PSHA_RS11510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PSHA_RS11515	COG2066	Belongs to the glutaminase family
PSHA_RS11540	COG3118	belongs to the thioredoxin family
PSHA_RS11545	COG1473	amidohydrolase
PSHA_RS11600	COG0784	Response regulator, receiver
PSHA_RS11600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PSHA_RS11605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PSHA_RS11630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PSHA_RS11640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PSHA_RS11645	COG1722	exodeoxyribonuclease VII activity
PSHA_RS11650	COG0142	geranyltranstransferase activity
PSHA_RS11655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PSHA_RS11660	COG3706	GGDEF domain
PSHA_RS11665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PSHA_RS11675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PSHA_RS11680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PSHA_RS11695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PSHA_RS11695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PSHA_RS11700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PSHA_RS11705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PSHA_RS11710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PSHA_RS11730	COG2974	May be involved in recombination
PSHA_RS11760	COG0840	transmembrane signaling receptor activity
PSHA_RS11770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PSHA_RS11780	COG0667	Aldo Keto reductase
PSHA_RS11785	COG0179	Fumarylacetoacetate (FAA) hydrolase
PSHA_RS11790	COG2205	protein histidine kinase activity
PSHA_RS11790	COG0784	Response regulator, receiver
PSHA_RS11795	COG0784	Response regulator, receiver
PSHA_RS11800	COG4251	negative regulation of phosphorylation
PSHA_RS11810	COG2204	response regulator
PSHA_RS11830	COG1012	belongs to the aldehyde dehydrogenase family
PSHA_RS11855	COG4206	TonB-dependent receptor
PSHA_RS11860	COG2207	Transcriptional regulator
PSHA_RS11865	COG2807	transmembrane transport
PSHA_RS11870	COG0251	oxidation-reduction process
PSHA_RS11885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PSHA_RS11900	COG1473	amidohydrolase
PSHA_RS11900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PSHA_RS11915	COG1959	2 iron, 2 sulfur cluster binding
PSHA_RS11930	COG0795	lipopolysaccharide-transporting ATPase activity
PSHA_RS11935	COG0795	lipopolysaccharide-transporting ATPase activity
PSHA_RS11940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PSHA_RS11945	COG2927	DNA polymerase III (CHI subunit)
PSHA_RS11950	COG0525	valine-tRNA ligase activity
PSHA_RS11955	COG2067	long-chain fatty acid transport protein
PSHA_RS11965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PSHA_RS12000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PSHA_RS12005	COG0305	Participates in initiation and elongation during chromosome replication
PSHA_RS12020	COG1595	DNA-templated transcription, initiation
PSHA_RS12025	COG0359	binds to the 23S rRNA
PSHA_RS12030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PSHA_RS12035	COG2965	DNA replication, synthesis of RNA primer
PSHA_RS12040	COG0360	Binds together with S18 to 16S ribosomal RNA
PSHA_RS12050	COG0668	transmembrane transport
PSHA_RS12060	COG1902	pentaerythritol trinitrate reductase activity
PSHA_RS12080	COG3615	Tellurite resistance protein tehB
PSHA_RS12090	COG1823	symporter activity
PSHA_RS12100	COG0754	glutathionylspermidine amidase activity
PSHA_RS12105	COG0783	Belongs to the Dps family
PSHA_RS12130	COG2076	Multidrug Resistance protein
PSHA_RS12155	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
PSHA_RS12175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PSHA_RS12175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PSHA_RS12180	COG0509	glycine decarboxylation via glycine cleavage system
PSHA_RS12185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PSHA_RS12195	COG0583	DNA-binding transcription factor activity
PSHA_RS12200	COG4774	siderophore transport
PSHA_RS12205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSHA_RS12210	COG0557	exoribonuclease II activity
PSHA_RS12215	COG1024	Enoyl-CoA hydratase
PSHA_RS12225	COG0584	glycerophosphoryl diester phosphodiesterase
PSHA_RS12230	COG0840	transmembrane signaling receptor activity
PSHA_RS12235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PSHA_RS12240	COG1247	-acetyltransferase
PSHA_RS12255	COG0625	glutathione transferase activity
PSHA_RS12285	COG3954	Phosphoribulokinase
PSHA_RS12290	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
PSHA_RS12295	COG1011	Hydrolase
PSHA_RS12300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PSHA_RS12310	COG0849	cell division
PSHA_RS12315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PSHA_RS12320	COG1181	Belongs to the D-alanine--D-alanine ligase family
PSHA_RS12325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PSHA_RS12330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PSHA_RS12335	COG0772	Belongs to the SEDS family
PSHA_RS12340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PSHA_RS12345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PSHA_RS12350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PSHA_RS12355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PSHA_RS12360	COG0768	penicillin binding
PSHA_RS12365	COG3116	cell division
PSHA_RS12370	COG0275	rRNA processing
PSHA_RS12375	COG2001	Belongs to the MraZ family
PSHA_RS12395	COG1741	Belongs to the pirin family
PSHA_RS12405	COG1295	ribonuclease BN
PSHA_RS12415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PSHA_RS12420	COG3107	peptidoglycan biosynthetic process
PSHA_RS12425	COG0792	nuclease activity
PSHA_RS12435	COG2823	Periplasmic or secreted lipoprotein
PSHA_RS12440	COG2969	positive regulation of protein catabolic process
PSHA_RS12445	COG0625	glutathione transferase activity
PSHA_RS12450	COG2857	Cytochrome c1
PSHA_RS12455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PSHA_RS12460	COG0723	plastoquinol--plastocyanin reductase activity
PSHA_RS12465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PSHA_RS12470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PSHA_RS12475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PSHA_RS12485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PSHA_RS12495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PSHA_RS12500	COG5007	Belongs to the BolA IbaG family
PSHA_RS12505	COG3113	response to antibiotic
PSHA_RS12510	COG2854	intermembrane phospholipid transfer
PSHA_RS12515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PSHA_RS12520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PSHA_RS12525	COG1127	ABC transporter
PSHA_RS12540	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PSHA_RS12555	COG1137	ATPase activity
PSHA_RS12560	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PSHA_RS12575	COG1660	Displays ATPase and GTPase activities
PSHA_RS12580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PSHA_RS12585	COG2239	Acts as a magnesium transporter
PSHA_RS12590	COG0668	transmembrane transport
PSHA_RS12595	COG3022	response to hydroperoxide
PSHA_RS12600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PSHA_RS12610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PSHA_RS12615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PSHA_RS12620	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PSHA_RS12625	COG1492	cobalamin metabolic process
PSHA_RS12630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PSHA_RS12635	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PSHA_RS12645	COG0583	DNA-binding transcription factor activity
PSHA_RS12655	COG2962	Rard protein
PSHA_RS12660	COG2050	protein possibly involved in aromatic compounds catabolism
PSHA_RS12665	COG0514	ATP-dependent DNA helicase (RecQ)
PSHA_RS12690	COG0189	ligase activity
PSHA_RS12695	COG4067	protein conserved in archaea
PSHA_RS12695	COG0189	ligase activity
PSHA_RS12715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PSHA_RS12720	COG0204	Acyl-transferase
PSHA_RS12725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PSHA_RS12740	COG3150	esterase
PSHA_RS12750	COG3151	Protein conserved in bacteria
PSHA_RS12755	COG0494	nUDIX hydrolase
PSHA_RS12760	COG1538	Outer membrane efflux protein
PSHA_RS12765	COG1560	Kdo2-lipid A biosynthetic process
PSHA_RS12775	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PSHA_RS12790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PSHA_RS12795	COG0189	ligase activity
PSHA_RS12800	COG1678	Uncharacterized ACR, COG1678
PSHA_RS12805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PSHA_RS12820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PSHA_RS12825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PSHA_RS12830	COG0762	integral membrane protein
PSHA_RS12840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PSHA_RS12845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PSHA_RS12865	COG0045	succinate-CoA ligase (ADP-forming) activity
PSHA_RS12865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PSHA_RS12865	COG1042	CoA-binding domain protein
PSHA_RS12870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PSHA_RS12885	COG3313	Fe-S protein
PSHA_RS12895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PSHA_RS12905	COG3850	Histidine kinase
PSHA_RS12905	COG3437	response regulator, receiver
PSHA_RS12905	COG2205	protein histidine kinase activity
PSHA_RS12905	COG4999	Histidine kinase
PSHA_RS12910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PSHA_RS12915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PSHA_RS12940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PSHA_RS12955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PSHA_RS12960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSHA_RS12965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PSHA_RS12970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PSHA_RS12975	COG2967	ApaG domain
PSHA_RS12980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PSHA_RS12985	COG0840	transmembrane signaling receptor activity
PSHA_RS12995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PSHA_RS13000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PSHA_RS13005	COG2003	Belongs to the UPF0758 family
PSHA_RS13010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PSHA_RS13020	COG4946	Tricorn protease homolog
PSHA_RS13020	COG1506	peptidase
PSHA_RS13020	COG0823	Involved in the tonB-independent uptake of proteins
PSHA_RS13030	COG2081	HI0933 family
PSHA_RS13035	COG1404	Belongs to the peptidase S8 family
PSHA_RS13040	COG0678	peroxiredoxin activity
PSHA_RS13040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PSHA_RS13060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PSHA_RS13065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PSHA_RS13070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PSHA_RS13075	COG0142	geranyltranstransferase activity
PSHA_RS13080	COG0039	L-malate dehydrogenase activity
PSHA_RS13085	COG1438	arginine binding
PSHA_RS13095	COG3842	ATPase activity
PSHA_RS13105	COG1840	ABC-type Fe3 transport system, periplasmic component
PSHA_RS13120	COG0443	Heat shock 70 kDa protein
PSHA_RS13125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PSHA_RS13130	COG0316	Belongs to the HesB IscA family
PSHA_RS13135	COG0822	iron-sulfur transferase activity
PSHA_RS13140	COG1104	cysteine desulfurase activity
PSHA_RS13155	COG0312	modulator of DNA gyrase
PSHA_RS13160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PSHA_RS13165	COG3164	Protein of unknown function
PSHA_RS13170	COG1530	ribonuclease E activity
PSHA_RS13175	COG0424	maF-like protein
PSHA_RS13180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PSHA_RS13185	COG1792	Involved in formation and maintenance of cell shape
PSHA_RS13190	COG1077	Cell shape determining protein MreB Mrl
PSHA_RS13220	COG4969	Belongs to the N-Me-Phe pilin family
PSHA_RS13225	COG2165	general secretion pathway protein
PSHA_RS13230	COG2165	general secretion pathway protein
PSHA_RS13235	COG1459	type II secretion system
PSHA_RS13240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSHA_RS13250	COG3409	Peptidoglycan-binding domain 1 protein
PSHA_RS13250	COG3267	Type II secretory pathway component ExeA
PSHA_RS13295	COG4771	TonB-dependent receptor
PSHA_RS13305	COG0629	single-stranded DNA binding
PSHA_RS13310	COG2814	Major facilitator Superfamily
PSHA_RS13315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PSHA_RS13320	COG0180	Tryptophanyl-tRNA synthetase
PSHA_RS13330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PSHA_RS13345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PSHA_RS13355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PSHA_RS13360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PSHA_RS13390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PSHA_RS13395	COG0460	homoserine dehydrogenase
PSHA_RS13395	COG0527	aspartate kinase activity
PSHA_RS13400	COG0626	cystathionine gamma-synthase activity
PSHA_RS13405	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
PSHA_RS13410	COG0281	malic enzyme
PSHA_RS13415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PSHA_RS13425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PSHA_RS13430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PSHA_RS13445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PSHA_RS13460	COG1228	amidohydrolase
PSHA_RS13465	COG2188	Transcriptional regulator
PSHA_RS13470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PSHA_RS13480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PSHA_RS13490	COG0653	protein targeting
PSHA_RS13495	COG0494	nUDIX hydrolase
PSHA_RS13500	COG3590	peptidase
PSHA_RS13510	COG0312	modulator of DNA gyrase
PSHA_RS13540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PSHA_RS13555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PSHA_RS13555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PSHA_RS13560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PSHA_RS13575	COG0210	DNA helicase
PSHA_RS13580	COG2960	long-chain fatty acid transporting porin activity
PSHA_RS13590	COG0288	reversible hydration of carbon dioxide
PSHA_RS13605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PSHA_RS13610	COG0129	dihydroxy-acid dehydratase activity
PSHA_RS13625	COG2194	sulfuric ester hydrolase activity
PSHA_RS13630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PSHA_RS13635	COG1368	sulfuric ester hydrolase activity
PSHA_RS13645	COG5002	protein histidine kinase activity
PSHA_RS13655	COG1119	ATPase activity
PSHA_RS13685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PSHA_RS13690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PSHA_RS13695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PSHA_RS13700	COG1561	YicC-like family, N-terminal region
PSHA_RS13705	COG0194	GDP metabolic process
PSHA_RS13710	COG1758	RNA polymerase activity
PSHA_RS13715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PSHA_RS13730	COG2502	aspartate--ammonia ligase
PSHA_RS13735	COG1522	sequence-specific DNA binding
PSHA_RS13740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSHA_RS13745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PSHA_RS13765	COG0203	ribosomal protein L17
PSHA_RS13770	COG0202	RNA polymerase activity
PSHA_RS13775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PSHA_RS13780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PSHA_RS13785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PSHA_RS13790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PSHA_RS13795	COG0201	protein transport
PSHA_RS13800	COG0200	Binds to the 23S rRNA
PSHA_RS13805	COG1841	ribosomal large subunit assembly
PSHA_RS13810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PSHA_RS13815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PSHA_RS13820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PSHA_RS13825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PSHA_RS13830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PSHA_RS13835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PSHA_RS13840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PSHA_RS13845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PSHA_RS13875	COG1136	(ABC) transporter
PSHA_RS13880	COG0577	efflux transmembrane transporter activity
PSHA_RS13895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSHA_RS13905	COG0640	Transcriptional regulator
PSHA_RS13920	COG3713	MltA-interacting MipA family protein
PSHA_RS13925	COG1280	lysine exporter protein (LysE YggA)
PSHA_RS13935	COG1132	(ABC) transporter
PSHA_RS13940	COG2885	chlorophyll binding
PSHA_RS13950	COG0668	transmembrane transport
PSHA_RS13955	COG0204	Acyl-transferase
PSHA_RS13960	COG1166	arginine decarboxylase activity
PSHA_RS13965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PSHA_RS13970	COG1082	Xylose isomerase domain protein TIM barrel
PSHA_RS13985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PSHA_RS14000	COG2183	response to ionizing radiation
PSHA_RS14020	COG1040	competence protein
PSHA_RS14030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PSHA_RS14030	COG0316	Belongs to the HesB IscA family
PSHA_RS14040	COG0534	Mate efflux family protein
PSHA_RS14045	COG0726	polysaccharide deacetylase
PSHA_RS14055	COG0109	protoheme IX farnesyltransferase activity
PSHA_RS14080	COG1845	cytochrome c oxidase, subunit III
PSHA_RS14090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PSHA_RS14125	COG0484	heat shock protein binding
PSHA_RS14135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PSHA_RS14135	COG1017	nitric oxide dioxygenase activity
PSHA_RS14150	COG3604	Transcriptional regulator
PSHA_RS14160	COG0583	DNA-binding transcription factor activity
PSHA_RS14165	COG0431	NADPH-dependent FMN reductase
PSHA_RS14190	COG0066	3-isopropylmalate dehydratase activity
PSHA_RS14195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PSHA_RS14200	COG0473	3-isopropylmalate dehydrogenase activity
PSHA_RS14205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PSHA_RS14220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PSHA_RS14225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PSHA_RS14230	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
PSHA_RS14235	COG0545	Peptidyl-prolyl cis-trans isomerase
PSHA_RS14245	COG2900	Belongs to the SlyX family
PSHA_RS14250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PSHA_RS14255	COG0488	(ABC) transporter
PSHA_RS14265	COG0429	hydrolase of the alpha beta-hydrolase fold
PSHA_RS14270	COG3089	Belongs to the UPF0270 family
PSHA_RS14280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PSHA_RS14305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PSHA_RS14315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PSHA_RS14330	COG0537	adenosine 5'-monophosphoramidase activity
PSHA_RS14355	COG0235	Class ii aldolase
PSHA_RS14360	COG0069	glutamate synthase activity
PSHA_RS14375	COG2226	methyltransferase
PSHA_RS14390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PSHA_RS14395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PSHA_RS14400	COG0805	protein transport
PSHA_RS14410	COG0084	hydrolase, TatD family'
PSHA_RS14430	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PSHA_RS14435	COG3416	Protein conserved in bacteria
PSHA_RS14435	COG2943	transferase activity, transferring hexosyl groups
PSHA_RS14440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PSHA_RS14450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PSHA_RS14455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PSHA_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS14465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PSHA_RS14470	COG2610	gluconate transmembrane transporter activity
PSHA_RS14475	COG4771	TonB-dependent receptor
PSHA_RS14485	COG0784	Response regulator, receiver
PSHA_RS14485	COG2198	Histidine kinase
PSHA_RS14485	COG5002	protein histidine kinase activity
PSHA_RS14510	COG0783	Belongs to the Dps family
PSHA_RS14515	COG1770	oligopeptidase
PSHA_RS14520	COG3397	chitin binding
PSHA_RS14560	COG3428	Bacterial PH domain
PSHA_RS14570	COG0676	glucose-6-phosphate 1-epimerase activity
PSHA_RS14585	COG2832	Protein of unknown function (DUF454)
PSHA_RS14610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PSHA_RS14610	COG0475	glutathione-regulated potassium exporter activity
PSHA_RS14630	COG1278	Cold shock
PSHA_RS14635	COG1278	Cold shock
PSHA_RS14640	COG1278	Cold shock
PSHA_RS14645	COG0557	exoribonuclease II activity
PSHA_RS14655	COG0513	Belongs to the DEAD box helicase family
PSHA_RS14700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PSHA_RS14705	COG1349	DNA-binding transcription factor activity
PSHA_RS14710	COG0110	maltose O-acetyltransferase activity
PSHA_RS14720	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PSHA_RS14725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PSHA_RS14750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PSHA_RS14755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PSHA_RS14760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PSHA_RS14765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PSHA_RS14770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PSHA_RS14775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PSHA_RS14780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PSHA_RS14790	COG0356	it plays a direct role in the translocation of protons across the membrane
PSHA_RS14800	COG1475	DNA binding
PSHA_RS14805	COG1192	Involved in chromosome partitioning
PSHA_RS14810	COG0357	Ribosomal RNA small subunit methyltransferase G
PSHA_RS14815	COG0445	tRNA wobble uridine modification
PSHA_RS14820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PSHA_RS14825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PSHA_RS14830	COG0706	membrane insertase activity
PSHA_RS14835	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PSHA_RS14840	COG0594	ribonuclease P activity
PSHA_RS14845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PSHA_RS15645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PSHA_RS15725	COG2895	sulfate adenylyltransferase (ATP) activity
PSHA_RS15770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PSHA_RS15865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSHA_RS16050	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PSHA_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
PSHA_RS16185	COG0581	inorganic phosphate transmembrane transporter activity
PSHA_RS16225	COG5002	protein histidine kinase activity
PSHA_RS16225	COG5001	Diguanylate cyclase
PSHA_RS16340	COG2264	protein methyltransferase activity
PSHA_RS16415	COG4942	peptidase
PSHA_RS17320	COG0006	proline dipeptidase activity
PSHA_RS17555	COG4565	transcriptional regulatory protein