locus-tag	class	description
S40542_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S40542_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S40542_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
S40542_RS00030	COG0751	glycine-tRNA ligase activity
S40542_RS00040	COG0425	Belongs to the sulfur carrier protein TusA family
S40542_RS00045	COG0183	Belongs to the thiolase family
S40542_RS00050	COG1250	3-hydroxyacyl-CoA dehydrogenase
S40542_RS00050	COG1024	Enoyl-CoA hydratase
S40542_RS00065	COG1739	Uncharacterized protein family UPF0029
S40542_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S40542_RS00080	COG0569	domain protein
S40542_RS00085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S40542_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S40542_RS00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S40542_RS00095	COG0242	peptide deformylase activity
S40542_RS00105	COG0758	DNA mediated transformation
S40542_RS00110	COG2922	Belongs to the Smg family
S40542_RS00115	COG0551	DNA topoisomerase type I activity
S40542_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
S40542_RS00125	COG0408	coproporphyrinogen oxidase activity
S40542_RS00130	COG0840	transmembrane signaling receptor activity
S40542_RS00140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S40542_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S40542_RS00225	COG0739	heme binding
S40542_RS00245	COG0513	Belongs to the DEAD box helicase family
S40542_RS00250	COG3706	GGDEF domain
S40542_RS00250	COG4251	negative regulation of phosphorylation
S40542_RS00250	COG5001	Diguanylate cyclase
S40542_RS00250	COG2203	Gaf domain
S40542_RS00265	COG0784	Response regulator, receiver
S40542_RS00265	COG2205	protein histidine kinase activity
S40542_RS00295	COG0840	transmembrane signaling receptor activity
S40542_RS00300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S40542_RS00305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S40542_RS00350	COG0676	glucose-6-phosphate 1-epimerase activity
S40542_RS00355	COG2204	response regulator
S40542_RS00360	COG3852	Histidine kinase
S40542_RS00375	COG1404	Belongs to the peptidase S8 family
S40542_RS00380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S40542_RS00385	COG1136	(ABC) transporter
S40542_RS00385	COG0577	efflux transmembrane transporter activity
S40542_RS00400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S40542_RS00410	COG1770	oligopeptidase
S40542_RS00420	COG0783	Belongs to the Dps family
S40542_RS00435	COG4681	YaeQ
S40542_RS00440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S40542_RS00450	COG2610	gluconate transmembrane transporter activity
S40542_RS00460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S40542_RS00490	COG0805	protein transport
S40542_RS00495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S40542_RS00500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S40542_RS00505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S40542_RS00515	COG2226	methyltransferase
S40542_RS00530	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S40542_RS00535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S40542_RS00550	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
S40542_RS00555	COG0235	Class ii aldolase
S40542_RS00560	COG0436	Aminotransferase
S40542_RS00570	COG0840	transmembrane signaling receptor activity
S40542_RS00595	COG0537	adenosine 5'-monophosphoramidase activity
S40542_RS00610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S40542_RS00620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S40542_RS00645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S40542_RS00655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S40542_RS00705	COG1011	Hydrolase
S40542_RS00710	COG0494	nUDIX hydrolase
S40542_RS00715	COG1218	3'(2'),5'-bisphosphate nucleotidase
S40542_RS00750	COG0429	hydrolase of the alpha beta-hydrolase fold
S40542_RS00760	COG0488	(ABC) transporter
S40542_RS00765	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
S40542_RS00770	COG2900	Belongs to the SlyX family
S40542_RS00780	COG0545	Peptidyl-prolyl cis-trans isomerase
S40542_RS00785	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
S40542_RS00795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S40542_RS00800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S40542_RS00805	COG1166	arginine decarboxylase activity
S40542_RS00810	COG0204	Acyl-transferase
S40542_RS00815	COG0204	Acyl-transferase
S40542_RS00820	COG0668	transmembrane transport
S40542_RS00840	COG0640	Transcriptional regulator
S40542_RS00860	COG0179	Fumarylacetoacetate (FAA) hydrolase
S40542_RS00870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S40542_RS00880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S40542_RS00885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S40542_RS00905	COG4555	ABC transporter
S40542_RS00915	COG0726	polysaccharide deacetylase
S40542_RS00920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S40542_RS00925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S40542_RS00930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S40542_RS00935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S40542_RS00940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S40542_RS00945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S40542_RS00950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S40542_RS00955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S40542_RS00960	COG1841	ribosomal large subunit assembly
S40542_RS00965	COG0200	Binds to the 23S rRNA
S40542_RS00970	COG0201	protein transport
S40542_RS00975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S40542_RS00980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S40542_RS00985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S40542_RS00990	COG0202	RNA polymerase activity
S40542_RS00995	COG0203	ribosomal protein L17
S40542_RS01025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S40542_RS01030	COG1132	(ABC) transporter
S40542_RS01040	COG1049	propionate catabolic process, 2-methylcitrate cycle
S40542_RS01060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S40542_RS01075	COG3852	Histidine kinase
S40542_RS01085	COG0174	glutamine synthetase
S40542_RS01095	COG0577	efflux transmembrane transporter activity
S40542_RS01095	COG1136	(ABC) transporter
S40542_RS01105	COG5002	protein histidine kinase activity
S40542_RS01110	COG2204	response regulator
S40542_RS01115	COG1217	gtp-binding protein TYPA
S40542_RS01130	COG1444	tRNA N-acetyltransferase activity
S40542_RS01135	COG0210	DNA helicase
S40542_RS01140	COG0835	chemotaxis
S40542_RS01140	COG0784	Response regulator, receiver
S40542_RS01160	COG1946	Acyl-CoA thioesterase
S40542_RS01165	COG2937	Belongs to the GPAT DAPAT family
S40542_RS01170	COG0051	transcription antitermination factor activity, RNA binding
S40542_RS01175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S40542_RS01180	COG0088	Forms part of the polypeptide exit tunnel
S40542_RS01185	COG0089	rRNA binding
S40542_RS01190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S40542_RS01195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S40542_RS01200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S40542_RS01205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S40542_RS01210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S40542_RS01215	COG0255	Belongs to the universal ribosomal protein uL29 family
S40542_RS01220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S40542_RS01235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S40542_RS01240	COG0840	transmembrane signaling receptor activity
S40542_RS01245	COG0840	transmembrane signaling receptor activity
S40542_RS01260	COG1228	amidohydrolase
S40542_RS01265	COG2200	EAL domain
S40542_RS01275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S40542_RS01280	COG0671	phosphoesterase, PA-phosphatase related
S40542_RS01300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S40542_RS01305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S40542_RS01315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S40542_RS01320	COG0254	rRNA binding
S40542_RS01325	COG0281	malic enzyme
S40542_RS01330	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
S40542_RS01335	COG0626	cystathionine gamma-synthase activity
S40542_RS01340	COG0460	homoserine dehydrogenase
S40542_RS01340	COG0527	aspartate kinase activity
S40542_RS01345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S40542_RS01375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S40542_RS01380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S40542_RS01390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S40542_RS01405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S40542_RS01415	COG0180	Tryptophanyl-tRNA synthetase
S40542_RS01430	COG0019	diaminopimelate decarboxylase activity
S40542_RS01440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S40542_RS01445	COG5002	protein histidine kinase activity
S40542_RS01445	COG0784	Response regulator, receiver
S40542_RS01465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S40542_RS01470	COG0129	dihydroxy-acid dehydratase activity
S40542_RS01475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S40542_RS01490	COG0288	reversible hydration of carbon dioxide
S40542_RS01505	COG3300	MHYT domain
S40542_RS01505	COG5001	Diguanylate cyclase
S40542_RS01515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
S40542_RS01520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S40542_RS01520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S40542_RS01535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S40542_RS01570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S40542_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
S40542_RS01590	COG1765	OsmC-like protein
S40542_RS01595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S40542_RS01615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S40542_RS01630	COG2022	thiamine diphosphate biosynthetic process
S40542_RS01635	COG0352	thiamine-phosphate diphosphorylase activity
S40542_RS01640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S40542_RS01645	COG0688	phosphatidylethanolamine metabolic process
S40542_RS01650	COG1162	GTPase activity
S40542_RS01655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
S40542_RS01690	COG0360	Binds together with S18 to 16S ribosomal RNA
S40542_RS01695	COG2965	DNA replication, synthesis of RNA primer
S40542_RS01700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S40542_RS01705	COG0359	binds to the 23S rRNA
S40542_RS01715	COG4969	Belongs to the N-Me-Phe pilin family
S40542_RS01750	COG0305	Participates in initiation and elongation during chromosome replication
S40542_RS01755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S40542_RS01770	COG0735	belongs to the Fur family
S40542_RS01825	COG0439	Biotin carboxylase
S40542_RS01830	COG0511	ligase activity, forming carbon-carbon bonds
S40542_RS01835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S40542_RS01840	COG4232	protein-disulfide reductase activity
S40542_RS01845	COG1324	tolerance protein
S40542_RS01855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S40542_RS01860	COG0459	protein refolding
S40542_RS01880	COG3710	Transcriptional regulator
S40542_RS01880	COG0457	Tetratricopeptide repeat
S40542_RS01905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S40542_RS01915	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
S40542_RS01940	COG0109	protoheme IX farnesyltransferase activity
S40542_RS01945	COG1999	signal sequence binding
S40542_RS01955	COG0745	RESPONSE REGULATOR receiver
S40542_RS01960	COG2198	Histidine kinase
S40542_RS01960	COG0643	Histidine kinase
S40542_RS01970	COG0840	transmembrane signaling receptor activity
S40542_RS01975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S40542_RS01980	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S40542_RS01995	COG0534	Mate efflux family protein
S40542_RS02000	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S40542_RS02000	COG0316	Belongs to the HesB IscA family
S40542_RS02010	COG1040	competence protein
S40542_RS02015	COG0596	Alpha beta hydrolase
S40542_RS02030	COG2183	response to ionizing radiation
S40542_RS02035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S40542_RS02050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S40542_RS02055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S40542_RS02065	COG3031	protein transport across the cell outer membrane
S40542_RS02075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S40542_RS02080	COG1459	type II secretion system
S40542_RS02085	COG2165	general secretion pathway protein
S40542_RS02095	COG2165	general secretion pathway protein
S40542_RS02105	COG3156	type II secretion system protein K
S40542_RS02140	COG0348	domain, Protein
S40542_RS02145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S40542_RS02150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S40542_RS02160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S40542_RS02175	COG0724	RNA recognition motif
S40542_RS02240	COG1136	(ABC) transporter
S40542_RS02240	COG0577	efflux transmembrane transporter activity
S40542_RS02245	COG1136	(ABC) transporter
S40542_RS02250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S40542_RS02255	COG5001	Diguanylate cyclase
S40542_RS02255	COG3300	MHYT domain
S40542_RS02260	COG0859	PFAM glycosyl transferase family 9
S40542_RS02280	COG1172	Belongs to the binding-protein-dependent transport system permease family
S40542_RS02285	COG1129	ABC transporter
S40542_RS02295	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
S40542_RS02310	COG0612	Peptidase, M16
S40542_RS02315	COG1045	serine acetyltransferase
S40542_RS02325	COG1570	exodeoxyribonuclease VII activity
S40542_RS02330	COG0517	IMP dehydrogenase activity
S40542_RS02330	COG0516	GMP reductase activity
S40542_RS02335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S40542_RS02335	COG0519	Catalyzes the synthesis of GMP from XMP
S40542_RS02350	COG0456	acetyltransferase
S40542_RS02355	COG2205	protein histidine kinase activity
S40542_RS02355	COG0784	Response regulator, receiver
S40542_RS02365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S40542_RS02390	COG0018	arginyl-trna synthetase
S40542_RS02395	COG0259	pyridoxamine-phosphate oxidase activity
S40542_RS02400	COG0084	hydrolase, TatD family'
S40542_RS02410	COG0560	Phosphoserine phosphatase
S40542_RS02420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
S40542_RS02425	COG0508	dehydrogenase complex catalyzes the overall conversion of
S40542_RS02430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S40542_RS02450	COG3409	Peptidoglycan-binding domain 1 protein
S40542_RS02450	COG3267	Type II secretory pathway component ExeA
S40542_RS02465	COG1473	amidohydrolase
S40542_RS02475	COG1349	DNA-binding transcription factor activity
S40542_RS02480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S40542_RS02495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S40542_RS02500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S40542_RS02510	COG3437	response regulator, receiver
S40542_RS02520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S40542_RS02525	COG0789	Transcriptional regulator
S40542_RS02530	COG0701	Predicted permease
S40542_RS02550	COG0006	proline dipeptidase activity
S40542_RS02555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S40542_RS02560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S40542_RS02565	COG0583	DNA-binding transcription factor activity
S40542_RS02570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S40542_RS02575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S40542_RS02580	COG0509	glycine decarboxylation via glycine cleavage system
S40542_RS02585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S40542_RS02585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S40542_RS02605	COG3710	Transcriptional regulator
S40542_RS02625	COG4191	Histidine kinase
S40542_RS02625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S40542_RS02630	COG0784	Response regulator, receiver
S40542_RS02630	COG3437	response regulator, receiver
S40542_RS02640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S40542_RS02665	COG1132	(ABC) transporter
S40542_RS02670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S40542_RS02675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S40542_RS02690	COG1690	Belongs to the RtcB family
S40542_RS02695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S40542_RS02745	COG0840	transmembrane signaling receptor activity
S40542_RS02760	COG2032	superoxide dismutase activity
S40542_RS02790	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS02795	COG1733	regulation of RNA biosynthetic process
S40542_RS02800	COG1823	symporter activity
S40542_RS02810	COG4585	Histidine kinase
S40542_RS02815	COG2197	response regulator
S40542_RS02830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S40542_RS02840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S40542_RS02840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S40542_RS02880	COG2059	Chromate
S40542_RS02885	COG0583	DNA-binding transcription factor activity
S40542_RS02895	COG0583	DNA-binding transcription factor activity
S40542_RS02910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S40542_RS02930	COG0848	biopolymer transport protein
S40542_RS02985	COG0823	Involved in the tonB-independent uptake of proteins
S40542_RS02985	COG1506	peptidase
S40542_RS02985	COG4946	Tricorn protease homolog
S40542_RS02990	COG0390	transport system, permease component
S40542_RS03005	COG0095	Lipoate-protein ligase
S40542_RS03020	COG3036	rescue of stalled ribosome
S40542_RS03035	COG1115	amino acid carrier protein
S40542_RS03040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S40542_RS03045	COG1132	(ABC) transporter
S40542_RS03105	COG0823	Involved in the tonB-independent uptake of proteins
S40542_RS03105	COG1506	peptidase
S40542_RS03105	COG4946	Tricorn protease homolog
S40542_RS03120	COG2186	Transcriptional regulator
S40542_RS03125	COG0251	oxidation-reduction process
S40542_RS03135	COG4953	penicillin-binding protein 1C
S40542_RS03140	COG2373	Large extracellular alpha-helical protein
S40542_RS03155	COG0583	DNA-binding transcription factor activity
S40542_RS03160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S40542_RS03170	COG0237	dephospho-CoA kinase activity
S40542_RS03175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S40542_RS03190	COG0157	Belongs to the NadC ModD family
S40542_RS03200	COG3725	Membrane protein required for beta-lactamase induction
S40542_RS03210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S40542_RS03220	COG0739	heme binding
S40542_RS03225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S40542_RS03235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S40542_RS03245	COG1469	GTP cyclohydrolase I activity
S40542_RS03250	COG2198	Histidine kinase
S40542_RS03250	COG0784	Response regulator, receiver
S40542_RS03250	COG5002	protein histidine kinase activity
S40542_RS03255	COG0745	RESPONSE REGULATOR receiver
S40542_RS03265	COG4191	Histidine kinase
S40542_RS03265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S40542_RS03270	COG2813	Specifically methylates the guanine in position
S40542_RS03275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S40542_RS03280	COG1194	a g-specific adenine glycosylase
S40542_RS03285	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
S40542_RS03290	COG0142	geranyltranstransferase activity
S40542_RS03295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S40542_RS03300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S40542_RS03305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S40542_RS03325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S40542_RS03340	COG0346	lactoylglutathione lyase activity
S40542_RS03345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S40542_RS03350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S40542_RS03355	COG1522	sequence-specific DNA binding
S40542_RS03360	COG2502	aspartate--ammonia ligase
S40542_RS03375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S40542_RS03380	COG1758	RNA polymerase activity
S40542_RS03385	COG0194	GDP metabolic process
S40542_RS03405	COG2963	transposase activity
S40542_RS03490	COG1561	YicC-like family, N-terminal region
S40542_RS03495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S40542_RS03500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S40542_RS03505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S40542_RS03510	COG0163	prenyltransferase activity
S40542_RS03515	COG1131	(ABC) transporter
S40542_RS03520	COG0842	Transport permease protein
S40542_RS03530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S40542_RS03540	COG0076	glutamate decarboxylase activity
S40542_RS03550	COG2205	protein histidine kinase activity
S40542_RS03550	COG0784	Response regulator, receiver
S40542_RS03560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S40542_RS03575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S40542_RS03580	COG0126	phosphoglycerate kinase activity
S40542_RS03595	COG0745	RESPONSE REGULATOR receiver
S40542_RS03600	COG5002	protein histidine kinase activity
S40542_RS03615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S40542_RS03620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S40542_RS03625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S40542_RS03635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S40542_RS03645	COG1489	DNA binding
S40542_RS03650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S40542_RS03655	COG0517	IMP dehydrogenase activity
S40542_RS03665	COG0793	Belongs to the peptidase S41A family
S40542_RS03670	COG4942	peptidase
S40542_RS03675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S40542_RS03680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S40542_RS03685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S40542_RS03690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S40542_RS03695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S40542_RS03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S40542_RS03715	COG0788	formyltetrahydrofolate deformylase activity
S40542_RS03750	COG1846	Transcriptional regulator
S40542_RS03755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S40542_RS03795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S40542_RS03800	COG0339	signal peptide processing
S40542_RS03805	COG0745	RESPONSE REGULATOR receiver
S40542_RS03810	COG0742	ribosomal rna small subunit methyltransferase
S40542_RS03820	COG1404	Belongs to the peptidase S8 family
S40542_RS03825	COG2081	HI0933 family
S40542_RS03855	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
S40542_RS03900	COG1858	cytochrome C peroxidase
S40542_RS03905	COG5002	protein histidine kinase activity
S40542_RS03905	COG0784	Response regulator, receiver
S40542_RS03905	COG2205	protein histidine kinase activity
S40542_RS03910	COG4221	oxidoreductase activity
S40542_RS03935	COG1595	DNA-templated transcription, initiation
S40542_RS03940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S40542_RS03980	COG0826	peptidase U32
S40542_RS03985	COG0105	UTP biosynthetic process
S40542_RS03990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S40542_RS04000	COG1426	Protein conserved in bacteria
S40542_RS04005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S40542_RS04010	COG0124	histidyl-tRNA synthetase
S40542_RS04015	COG2976	Protein conserved in bacteria
S40542_RS04020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S40542_RS04025	COG1160	GTP binding
S40542_RS04055	COG0784	Response regulator, receiver
S40542_RS04055	COG2205	protein histidine kinase activity
S40542_RS04060	COG3437	response regulator, receiver
S40542_RS04065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S40542_RS04070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S40542_RS04070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S40542_RS04075	COG0802	atpase or kinase
S40542_RS04085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S40542_RS04090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S40542_RS04095	COG1923	regulation of RNA biosynthetic process
S40542_RS04100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S40542_RS04105	COG0330	HflC and HflK could
S40542_RS04110	COG0330	HflC and HflK could
S40542_RS04115	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S40542_RS04120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
S40542_RS04130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S40542_RS04160	COG3122	Protein conserved in bacteria
S40542_RS04175	COG4948	Mandelate Racemase Muconate Lactonizing
S40542_RS04180	COG0483	inositol monophosphate 1-phosphatase activity
S40542_RS04195	COG1104	cysteine desulfurase activity
S40542_RS04200	COG0822	iron-sulfur transferase activity
S40542_RS04210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
S40542_RS04215	COG0443	Heat shock 70 kDa protein
S40542_RS04240	COG0673	inositol 2-dehydrogenase activity
S40542_RS04285	COG0514	ATP-dependent DNA helicase (RecQ)
S40542_RS04290	COG2962	Rard protein
S40542_RS04300	COG3085	chromosome segregation
S40542_RS04305	COG0583	DNA-binding transcription factor activity
S40542_RS04340	COG3604	Transcriptional regulator
S40542_RS04350	COG1061	Type III restriction enzyme res subunit
S40542_RS04385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S40542_RS04420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S40542_RS04440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S40542_RS04445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S40542_RS04450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S40542_RS04455	COG0585	pseudouridine synthase activity
S40542_RS04460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
S40542_RS04465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S40542_RS04470	COG4942	peptidase
S40542_RS04470	COG1388	LysM domain
S40542_RS04480	COG0525	valine-tRNA ligase activity
S40542_RS04485	COG2927	DNA polymerase III (CHI subunit)
S40542_RS04490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S40542_RS04495	COG0795	lipopolysaccharide-transporting ATPase activity
S40542_RS04500	COG0795	lipopolysaccharide-transporting ATPase activity
S40542_RS04515	COG4191	Histidine kinase
S40542_RS04515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S40542_RS04525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S40542_RS04530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S40542_RS04540	COG0762	integral membrane protein
S40542_RS04545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S40542_RS04550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S40542_RS04570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S40542_RS04575	COG1678	Uncharacterized ACR, COG1678
S40542_RS04580	COG0189	ligase activity
S40542_RS04585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S40542_RS04600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S40542_RS04610	COG1560	Kdo2-lipid A biosynthetic process
S40542_RS04615	COG1538	Outer membrane efflux protein
S40542_RS04620	COG0494	nUDIX hydrolase
S40542_RS04635	COG3150	esterase
S40542_RS04645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S40542_RS04655	COG2066	Belongs to the glutaminase family
S40542_RS04660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S40542_RS04670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
S40542_RS04675	COG0047	phosphoribosylformylglycinamidine synthase activity
S40542_RS04675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S40542_RS04700	COG3784	Protein of unknown function (DUF1318)
S40542_RS04710	COG1519	Transferase
S40542_RS04720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S40542_RS04725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S40542_RS04725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S40542_RS04730	COG3642	lipopolysaccharide core region biosynthetic process
S40542_RS04735	COG0859	PFAM glycosyl transferase family 9
S40542_RS04740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
S40542_RS04745	COG0156	8-amino-7-oxononanoate synthase activity
S40542_RS04750	COG1063	alcohol dehydrogenase
S40542_RS04755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S40542_RS04765	COG1580	Controls the rotational direction of flagella during chemotaxis
S40542_RS04770	COG3161	chorismate lyase activity
S40542_RS04775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
S40542_RS04780	COG0583	DNA-binding transcription factor activity
S40542_RS04785	COG3437	response regulator, receiver
S40542_RS04785	COG0784	Response regulator, receiver
S40542_RS04805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S40542_RS04810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S40542_RS04815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S40542_RS04820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S40542_RS04820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S40542_RS04825	COG1968	undecaprenyl-diphosphatase activity
S40542_RS04835	COG3148	PFAM DTW domain containing protein
S40542_RS04840	COG1840	ABC-type Fe3 transport system, periplasmic component
S40542_RS04850	COG3842	ATPase activity
S40542_RS04860	COG1438	arginine binding
S40542_RS04865	COG0039	L-malate dehydrogenase activity
S40542_RS04870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S40542_RS04875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S40542_RS04880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S40542_RS04895	COG3706	GGDEF domain
S40542_RS04900	COG0347	Belongs to the P(II) protein family
S40542_RS04905	COG0004	ammonium transporteR
S40542_RS04910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S40542_RS04920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S40542_RS04925	COG0540	Belongs to the ATCase OTCase family
S40542_RS04930	COG1981	membrane
S40542_RS04940	COG0316	Belongs to the HesB IscA family
S40542_RS04950	COG2223	nitrite transmembrane transporter activity
S40542_RS04965	COG2813	Specifically methylates the guanine in position
S40542_RS04975	COG0271	Belongs to the BolA IbaG family
S40542_RS04980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S40542_RS04985	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
S40542_RS04990	COG1805	sodium ion transport
S40542_RS04995	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
S40542_RS05000	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
S40542_RS05005	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
S40542_RS05010	COG2871	sodium ion transport
S40542_RS05015	COG1477	protein flavinylation
S40542_RS05030	COG1120	ATPase activity
S40542_RS05035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S40542_RS05040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S40542_RS05045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S40542_RS05055	COG1492	cobalamin metabolic process
S40542_RS05060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
S40542_RS05070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S40542_RS05090	COG3022	response to hydroperoxide
S40542_RS05095	COG2814	Major facilitator Superfamily
S40542_RS05105	COG0513	Belongs to the DEAD box helicase family
S40542_RS05110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S40542_RS05120	COG0716	FMN binding
S40542_RS05130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S40542_RS05140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S40542_RS05145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S40542_RS05190	COG3876	Protein conserved in bacteria
S40542_RS05195	COG1737	Transcriptional regulator
S40542_RS05200	COG1757	Na H antiporter
S40542_RS05215	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
S40542_RS05225	COG3706	GGDEF domain
S40542_RS05255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S40542_RS05260	COG0527	aspartate kinase activity
S40542_RS05265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S40542_RS05275	COG3630	sodium ion export across plasma membrane
S40542_RS05280	COG0511	ligase activity, forming carbon-carbon bonds
S40542_RS05280	COG5016	pyruvate
S40542_RS05285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
S40542_RS05375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S40542_RS05380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S40542_RS05380	COG0045	succinate-CoA ligase (ADP-forming) activity
S40542_RS05380	COG1042	CoA-binding domain protein
S40542_RS05395	COG0667	Aldo Keto reductase
S40542_RS05400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S40542_RS05405	COG1966	Carbon starvation protein
S40542_RS05410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S40542_RS05430	COG2974	May be involved in recombination
S40542_RS05435	COG4191	Histidine kinase
S40542_RS05455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S40542_RS05460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S40542_RS05465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S40542_RS05470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S40542_RS05470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S40542_RS05485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S40542_RS05490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S40542_RS05495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S40542_RS05500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S40542_RS05525	COG3243	poly(R)-hydroxyalkanoic acid synthase
S40542_RS05540	COG1054	Belongs to the UPF0176 family
S40542_RS05545	COG1902	pentaerythritol trinitrate reductase activity
S40542_RS05560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S40542_RS05565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S40542_RS05575	COG0625	glutathione transferase activity
S40542_RS05605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S40542_RS05610	COG0321	lipoyl(octanoyl) transferase activity
S40542_RS05615	COG2921	Belongs to the UPF0250 family
S40542_RS05620	COG1686	Belongs to the peptidase S11 family
S40542_RS05625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S40542_RS05630	COG0772	Belongs to the SEDS family
S40542_RS05635	COG0768	penicillin binding
S40542_RS05640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S40542_RS05645	COG0799	negative regulation of ribosome biogenesis
S40542_RS05665	COG0495	leucyl-tRNA aminoacylation
S40542_RS05675	COG1067	ATP-dependent peptidase activity
S40542_RS05680	COG0545	Peptidyl-prolyl cis-trans isomerase
S40542_RS05705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S40542_RS05710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S40542_RS05715	COG0840	transmembrane signaling receptor activity
S40542_RS05720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S40542_RS05725	COG2967	ApaG domain
S40542_RS05730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S40542_RS05735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S40542_RS05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S40542_RS05745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S40542_RS05750	COG3178	'Phosphotransferase
S40542_RS05755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S40542_RS05760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
S40542_RS05780	COG0205	6-phosphofructokinase activity
S40542_RS05790	COG2315	Protein conserved in bacteria
S40542_RS05795	COG5001	Diguanylate cyclase
S40542_RS05795	COG3300	MHYT domain
S40542_RS05810	COG4771	TonB-dependent receptor
S40542_RS05820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S40542_RS05830	COG0443	Heat shock 70 kDa protein
S40542_RS05835	COG1803	Methylglyoxal synthase
S40542_RS05860	COG1196	nuclear chromosome segregation
S40542_RS05860	COG0739	heme binding
S40542_RS05860	COG0741	lytic transglycosylase activity
S40542_RS05865	COG0179	Fumarylacetoacetate (FAA) hydrolase
S40542_RS05875	COG3104	oligopeptide transport
S40542_RS05935	COG3047	cAMP biosynthetic process
S40542_RS05975	COG0779	Required for maturation of 30S ribosomal subunits
S40542_RS05980	COG0195	Participates in both transcription termination and antitermination
S40542_RS05985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S40542_RS05990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S40542_RS05995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S40542_RS06000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S40542_RS06005	COG1185	polyribonucleotide nucleotidyltransferase activity
S40542_RS06020	COG2111	Na H antiporter
S40542_RS06020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S40542_RS06025	COG1006	Multisubunit Na H antiporter MnhC subunit
S40542_RS06030	COG0651	ATP synthesis coupled electron transport
S40542_RS06035	COG1863	multisubunit Na H antiporter MnhE subunit
S40542_RS06040	COG2212	antiporter activity
S40542_RS06045	COG1320	monovalent cation:proton antiporter activity
S40542_RS06055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S40542_RS06060	COG3118	belongs to the thioredoxin family
S40542_RS06080	COG1815	bacterial-type flagellum-dependent cell motility
S40542_RS06085	COG1558	bacterial-type flagellum-dependent cell motility
S40542_RS06100	COG4786	Flagellar basal body rod
S40542_RS06105	COG4786	Flagellar basal body rod
S40542_RS06110	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
S40542_RS06115	COG1706	bacterial-type flagellum-dependent cell motility
S40542_RS06120	COG1705	Flagellar rod assembly protein muramidase FlgJ
S40542_RS06120	COG3951	Flagellar rod assembly protein muramidase FlgJ
S40542_RS06125	COG1256	bacterial-type flagellum assembly
S40542_RS06160	COG1516	flagellar protein fliS
S40542_RS06175	COG4310	Domain of unknown function (DUF2172)
S40542_RS06180	COG2226	methyltransferase
S40542_RS06215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S40542_RS06215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S40542_RS06220	COG1063	alcohol dehydrogenase
S40542_RS06225	COG1091	dTDP-4-dehydrorhamnose reductase activity
S40542_RS06240	COG3958	Transketolase
S40542_RS06245	COG3959	Transketolase, thiamine diphosphate binding domain
S40542_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS06255	COG0022	dehydrogenase e1 component
S40542_RS06255	COG0508	dehydrogenase complex catalyzes the overall conversion of
S40542_RS06260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S40542_RS06270	COG2813	Specifically methylates the guanine in position
S40542_RS06275	COG1088	dTDP-glucose 4,6-dehydratase activity
S40542_RS06285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S40542_RS06295	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S40542_RS06305	COG2089	acid synthase
S40542_RS06330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S40542_RS06335	COG1086	Polysaccharide biosynthesis protein
S40542_RS06340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S40542_RS06350	COG0519	Catalyzes the synthesis of GMP from XMP
S40542_RS06365	COG1677	Flagellar hook-basal body complex protein FliE
S40542_RS06375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S40542_RS06430	COG1684	flagellar biosynthetic protein fliR
S40542_RS06435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S40542_RS06440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S40542_RS06465	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
S40542_RS06470	COG2198	Histidine kinase
S40542_RS06470	COG0784	Response regulator, receiver
S40542_RS06470	COG0643	Histidine kinase
S40542_RS06475	COG2201	protein-glutamate methylesterase activity
S40542_RS06480	COG1192	Involved in chromosome partitioning
S40542_RS06490	COG0835	chemotaxis
S40542_RS06505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S40542_RS06530	COG4133	protoheme IX ABC transporter activity
S40542_RS06535	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S40542_RS06540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S40542_RS06545	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S40542_RS06550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S40542_RS06555	COG1138	Cytochrome C-type biogenesis protein
S40542_RS06565	COG4235	cytochrome complex assembly
S40542_RS06565	COG3088	subunit of a heme lyase
S40542_RS06575	COG2853	Lipoprotein
S40542_RS06585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S40542_RS06590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S40542_RS06600	COG2171	N-acyltransferase activity
S40542_RS06605	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S40542_RS06610	COG0024	Methionine aminopeptidase
S40542_RS06615	COG0052	Belongs to the universal ribosomal protein uS2 family
S40542_RS06620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S40542_RS06625	COG0528	UMP kinase activity
S40542_RS06630	COG0233	cytoplasmic translational termination
S40542_RS06635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S40542_RS06640	COG0575	Belongs to the CDS family
S40542_RS06645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S40542_RS06650	COG0750	zinc metalloprotease
S40542_RS06660	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
S40542_RS06665	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S40542_RS06670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S40542_RS06675	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S40542_RS06680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S40542_RS06685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S40542_RS06690	COG0587	DNA-directed DNA polymerase activity
S40542_RS06695	COG0825	malonyl-CoA metabolic process
S40542_RS06700	COG0037	tRNA processing
S40542_RS06710	COG2199	diguanylate cyclase activity
S40542_RS06710	COG2203	Gaf domain
S40542_RS06770	COG3385	transposase activity
S40542_RS06820	COG0523	cobalamin synthesis protein
S40542_RS06830	COG0492	ferredoxin-NADP+ reductase activity
S40542_RS06835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S40542_RS06855	COG1396	sequence-specific DNA binding
S40542_RS06860	COG3279	Response regulator of the LytR AlgR family
S40542_RS06865	COG3275	phosphorelay sensor kinase activity
S40542_RS06870	COG0596	Alpha beta hydrolase
S40542_RS06890	COG4335	DNA alkylation repair
S40542_RS06910	COG5002	protein histidine kinase activity
S40542_RS06915	COG0745	RESPONSE REGULATOR receiver
S40542_RS06965	COG0523	cobalamin synthesis protein
S40542_RS06970	COG1115	amino acid carrier protein
S40542_RS06990	COG3291	Pkd domain containing protein
S40542_RS07000	COG0346	lactoylglutathione lyase activity
S40542_RS07020	COG5001	Diguanylate cyclase
S40542_RS07030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S40542_RS07040	COG0072	phenylalanine-tRNA ligase activity
S40542_RS07045	COG0776	regulation of translation
S40542_RS07050	COG2200	EAL domain
S40542_RS07055	COG0366	Alpha amylase catalytic
S40542_RS07090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
S40542_RS07120	COG4555	ABC transporter
S40542_RS07125	COG1668	transmembrane transport
S40542_RS07135	COG0442	prolyl-tRNA aminoacylation
S40542_RS07140	COG1720	tRNA m6t6A37 methyltransferase activity
S40542_RS07150	COG4977	sequence-specific DNA binding
S40542_RS07150	COG1917	Cupin 2, conserved barrel domain protein
S40542_RS07165	COG0339	signal peptide processing
S40542_RS07180	COG4771	TonB-dependent receptor
S40542_RS07220	COG4191	Histidine kinase
S40542_RS07295	COG1131	(ABC) transporter
S40542_RS07345	COG5002	protein histidine kinase activity
S40542_RS07360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S40542_RS07365	COG0583	DNA-binding transcription factor activity
S40542_RS07385	COG0346	lactoylglutathione lyase activity
S40542_RS07670	COG2801	Transposase and inactivated derivatives
S40542_RS07675	COG2963	transposase activity
S40542_RS07715	COG1215	transferase activity, transferring glycosyl groups
S40542_RS07750	COG4221	oxidoreductase activity
S40542_RS07770	COG4251	negative regulation of phosphorylation
S40542_RS07775	COG0784	Response regulator, receiver
S40542_RS07795	COG2824	Alkylphosphonate utilization operon protein PhnA
S40542_RS07800	COG5001	Diguanylate cyclase
S40542_RS07800	COG3300	MHYT domain
S40542_RS07805	COG4251	negative regulation of phosphorylation
S40542_RS07810	COG4251	negative regulation of phosphorylation
S40542_RS07820	COG3290	protein histidine kinase activity
S40542_RS07825	COG2201	protein-glutamate methylesterase activity
S40542_RS07830	COG2203	Gaf domain
S40542_RS07830	COG5001	Diguanylate cyclase
S40542_RS07830	COG3706	GGDEF domain
S40542_RS07830	COG4251	negative regulation of phosphorylation
S40542_RS07840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
S40542_RS07845	COG0745	RESPONSE REGULATOR receiver
S40542_RS07850	COG2205	protein histidine kinase activity
S40542_RS07855	COG4452	Inner membrane protein CreD
S40542_RS07865	COG0519	Catalyzes the synthesis of GMP from XMP
S40542_RS07875	COG1309	transcriptional regulator
S40542_RS07910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S40542_RS07915	COG0070	glutamate synthase
S40542_RS07915	COG0069	glutamate synthase activity
S40542_RS07915	COG0067	glutamate synthase
S40542_RS07930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S40542_RS07935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S40542_RS07940	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S40542_RS07945	COG1231	oxidoreductase activity
S40542_RS07990	COG3706	GGDEF domain
S40542_RS07990	COG2203	Gaf domain
S40542_RS07990	COG4251	negative regulation of phosphorylation
S40542_RS07990	COG5001	Diguanylate cyclase
S40542_RS07995	COG0814	amino acid
S40542_RS08020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S40542_RS08025	COG3938	Belongs to the proline racemase family
S40542_RS08075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S40542_RS08090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S40542_RS08095	COG1136	(ABC) transporter
S40542_RS08105	COG0577	efflux transmembrane transporter activity
S40542_RS08105	COG1136	(ABC) transporter
S40542_RS08115	COG3852	Histidine kinase
S40542_RS08140	COG0504	CTP synthase activity
S40542_RS08145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S40542_RS08165	COG2079	MmgE PrpD family protein
S40542_RS08190	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S40542_RS08200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S40542_RS08200	COG1017	nitric oxide dioxygenase activity
S40542_RS08210	COG3604	Transcriptional regulator
S40542_RS08220	COG2193	ferroxidase activity
S40542_RS08240	COG5002	protein histidine kinase activity
S40542_RS08240	COG0784	Response regulator, receiver
S40542_RS08240	COG2205	protein histidine kinase activity
S40542_RS08245	COG2176	DNA-directed DNA polymerase activity
S40542_RS08255	COG1301	dicarboxylic acid transport
S40542_RS08295	COG3292	Two component regulator propeller
S40542_RS08295	COG0745	RESPONSE REGULATOR receiver
S40542_RS08295	COG2205	protein histidine kinase activity
S40542_RS08295	COG3292	Two component regulator propeller
S40542_RS08295	COG0745	RESPONSE REGULATOR receiver
S40542_RS08295	COG2205	protein histidine kinase activity
S40542_RS08345	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
S40542_RS08350	COG0582	viral genome integration into host DNA
S40542_RS08370	COG2963	transposase activity
S40542_RS08375	COG2801	Transposase and inactivated derivatives
S40542_RS08395	COG1397	ADP-ribosylglycohydrolase
S40542_RS08400	COG5433	transposase activity
S40542_RS08435	COG1944	ATP diphosphatase activity
S40542_RS08440	COG1619	proteins homologs of microcin C7 resistance protein MccF
S40542_RS08500	COG2249	NAD(P)H dehydrogenase (quinone) activity
S40542_RS08505	COG1733	regulation of RNA biosynthetic process
S40542_RS08510	COG2197	response regulator
S40542_RS08520	COG1309	transcriptional regulator
S40542_RS08600	COG0583	DNA-binding transcription factor activity
S40542_RS08620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S40542_RS08630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
S40542_RS08630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S40542_RS08635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S40542_RS08640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S40542_RS08645	COG2867	negative regulation of translational initiation
S40542_RS08650	COG2914	Belongs to the UPF0125 (RnfH) family
S40542_RS08665	COG1393	Belongs to the ArsC family
S40542_RS08670	COG4783	chaperone-mediated protein folding
S40542_RS08690	COG1104	cysteine desulfurase activity
S40542_RS08695	COG1609	Transcriptional regulator
S40542_RS08700	COG0166	Belongs to the GPI family
S40542_RS08705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S40542_RS08710	COG0363	glucosamine-6-phosphate deaminase activity
S40542_RS08740	COG0517	IMP dehydrogenase activity
S40542_RS08740	COG0516	GMP reductase activity
S40542_RS08745	COG1643	Atp-dependent helicase
S40542_RS08760	COG2205	protein histidine kinase activity
S40542_RS08765	COG0745	RESPONSE REGULATOR receiver
S40542_RS08785	COG1595	DNA-templated transcription, initiation
S40542_RS08795	COG2304	oxidoreductase activity
S40542_RS08815	COG0714	Associated with various cellular activities
S40542_RS08820	COG0183	Belongs to the thiolase family
S40542_RS08825	COG1024	Enoyl-CoA hydratase
S40542_RS08825	COG1250	3-hydroxyacyl-CoA dehydrogenase
S40542_RS08855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S40542_RS08865	COG3101	peptidyl-lysine hydroxylation
S40542_RS08890	COG4989	oxidoreductase activity
S40542_RS08955	COG1228	amidohydrolase
S40542_RS08970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
S40542_RS08975	COG3385	transposase activity
S40542_RS08980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S40542_RS08985	COG2226	methyltransferase
S40542_RS08995	COG2205	protein histidine kinase activity
S40542_RS08995	COG3437	response regulator, receiver
S40542_RS08995	COG4999	Histidine kinase
S40542_RS08995	COG3850	Histidine kinase
S40542_RS09010	COG2971	BadF BadG BcrA BcrD
S40542_RS09015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S40542_RS09025	COG0363	glucosamine-6-phosphate deaminase activity
S40542_RS09035	COG0626	cystathionine gamma-synthase activity
S40542_RS09040	COG2925	Exonuclease
S40542_RS09065	COG0848	biopolymer transport protein
S40542_RS09070	COG0811	peptide transport
S40542_RS09075	COG0811	peptide transport
S40542_RS09090	COG0583	DNA-binding transcription factor activity
S40542_RS09115	COG2815	serine threonine protein kinase
S40542_RS09115	COG0515	serine threonine protein kinase
S40542_RS09135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S40542_RS09140	COG0505	Belongs to the CarA family
S40542_RS09145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S40542_RS09150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S40542_RS09155	COG3604	Transcriptional regulator
S40542_RS09165	COG0589	response to stress
S40542_RS09185	COG2217	Heavy metal translocating P-type atpase
S40542_RS09195	COG2010	Cytochrome c
S40542_RS09210	COG3278	Belongs to the heme-copper respiratory oxidase family
S40542_RS09235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S40542_RS09240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S40542_RS09265	COG0583	DNA-binding transcription factor activity
S40542_RS09270	COG0659	secondary active sulfate transmembrane transporter activity
S40542_RS09275	COG4591	ABC-type transport system involved in lipoprotein release permease component
S40542_RS09280	COG1136	(ABC) transporter
S40542_RS09285	COG4591	ABC-type transport system involved in lipoprotein release permease component
S40542_RS09290	COG2199	diguanylate cyclase activity
S40542_RS09290	COG2200	EAL domain
S40542_RS09290	COG2203	Gaf domain
S40542_RS09295	COG2201	protein-glutamate methylesterase activity
S40542_RS09310	COG0835	chemotaxis
S40542_RS09315	COG0840	transmembrane signaling receptor activity
S40542_RS09320	COG0643	Histidine kinase
S40542_RS09320	COG2198	Histidine kinase
S40542_RS09350	COG2850	peptidyl-arginine hydroxylation
S40542_RS09355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S40542_RS09360	COG2915	High frequency lysogenization protein hflD homolog
S40542_RS09365	COG0482	sulfurtransferase activity
S40542_RS09370	COG1187	pseudouridine synthase activity
S40542_RS09380	COG1278	Cold shock
S40542_RS09385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S40542_RS09390	COG0542	response to heat
S40542_RS09395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S40542_RS09400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
S40542_RS09405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
S40542_RS09410	COG0492	ferredoxin-NADP+ reductase activity
S40542_RS09415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S40542_RS09420	COG4977	sequence-specific DNA binding
S40542_RS09420	COG1917	Cupin 2, conserved barrel domain protein
S40542_RS09445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S40542_RS09450	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
S40542_RS09460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S40542_RS09470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S40542_RS09480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S40542_RS09485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S40542_RS09490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S40542_RS09495	COG0539	negative regulation of cytoplasmic translation
S40542_RS09500	COG0776	regulation of translation
S40542_RS09510	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
S40542_RS09515	COG0284	orotidine-5'-phosphate decarboxylase activity
S40542_RS09520	COG0415	Belongs to the DNA photolyase family
S40542_RS09525	COG0415	Belongs to the DNA photolyase family
S40542_RS09530	COG3046	protein related to deoxyribodipyrimidine photolyase
S40542_RS09565	COG0545	Peptidyl-prolyl cis-trans isomerase
S40542_RS09575	COG1858	cytochrome C peroxidase
S40542_RS09590	COG1017	nitric oxide dioxygenase activity
S40542_RS09590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S40542_RS09600	COG0017	Asparaginyl-tRNA synthetase
S40542_RS09615	COG1509	lysine 2,3-aminomutase activity
S40542_RS09625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S40542_RS09630	COG0156	8-amino-7-oxononanoate synthase activity
S40542_RS09635	COG2226	methyltransferase
S40542_RS09640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S40542_RS09690	COG0534	Mate efflux family protein
S40542_RS09695	COG0307	riboflavin synthase, alpha
S40542_RS09705	COG3001	Fructosamine kinase
S40542_RS09720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S40542_RS09745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S40542_RS09775	COG1280	lysine exporter protein (LysE YggA)
S40542_RS09830	COG0840	transmembrane signaling receptor activity
S40542_RS09845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S40542_RS09880	COG0384	phenazine biosynthesis protein PhzF
S40542_RS09895	COG0644	oxidoreductase
S40542_RS09950	COG4251	negative regulation of phosphorylation
S40542_RS09955	COG2197	response regulator
S40542_RS09965	COG5001	Diguanylate cyclase
S40542_RS09965	COG3300	MHYT domain
S40542_RS09970	COG0784	Response regulator, receiver
S40542_RS09970	COG2205	protein histidine kinase activity
S40542_RS09990	COG2996	Protein conserved in bacteria
S40542_RS09995	COG0513	Belongs to the DEAD box helicase family
S40542_RS10000	COG1054	Belongs to the UPF0176 family
S40542_RS10005	COG2972	Histidine kinase
S40542_RS10010	COG3279	Response regulator of the LytR AlgR family
S40542_RS10030	COG1472	Belongs to the glycosyl hydrolase 3 family
S40542_RS10060	COG1683	Conserved Protein
S40542_RS10090	COG0242	peptide deformylase activity
S40542_RS10100	COG2315	Protein conserved in bacteria
S40542_RS10105	COG1280	lysine exporter protein (LysE YggA)
S40542_RS10140	COG3710	Transcriptional regulator
S40542_RS10155	COG0004	ammonium transporteR
S40542_RS10165	COG0730	response to heat
S40542_RS10180	COG0678	peroxiredoxin activity
S40542_RS10180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S40542_RS10185	COG0367	asparagine synthase
S40542_RS10205	COG1984	allophanate hydrolase subunit 2
S40542_RS10210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S40542_RS10215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S40542_RS10220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S40542_RS10245	COG4251	negative regulation of phosphorylation
S40542_RS10245	COG2203	Gaf domain
S40542_RS10245	COG5001	Diguanylate cyclase
S40542_RS10245	COG3706	GGDEF domain
S40542_RS10260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S40542_RS10265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S40542_RS10270	COG2855	membrane
S40542_RS10285	COG0405	Gamma-glutamyltransferase
S40542_RS10290	COG0281	malic enzyme
S40542_RS10360	COG2369	cell adhesion
S40542_RS10630	COG2205	protein histidine kinase activity
S40542_RS10630	COG0784	Response regulator, receiver
S40542_RS10635	COG2318	DinB family
S40542_RS10660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S40542_RS10675	COG0840	transmembrane signaling receptor activity
S40542_RS10680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S40542_RS10685	COG5001	Diguanylate cyclase
S40542_RS10685	COG3300	MHYT domain
S40542_RS10690	COG1288	antiporter activity
S40542_RS10720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S40542_RS10755	COG0189	ligase activity
S40542_RS10760	COG0583	DNA-binding transcription factor activity
S40542_RS10795	COG0492	ferredoxin-NADP+ reductase activity
S40542_RS10865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S40542_RS10880	COG1902	pentaerythritol trinitrate reductase activity
S40542_RS10880	COG0446	pyridine nucleotide-disulphide oxidoreductase
S40542_RS10885	COG0616	signal peptide processing
S40542_RS10890	COG0252	asparaginase activity
S40542_RS10895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S40542_RS10905	COG3279	Response regulator of the LytR AlgR family
S40542_RS10910	COG2972	Histidine kinase
S40542_RS10915	COG4774	siderophore transport
S40542_RS10925	COG2873	o-acetylhomoserine
S40542_RS10955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S40542_RS11000	COG1607	acyl-coa hydrolase
S40542_RS11005	COG4942	peptidase
S40542_RS11015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S40542_RS11020	COG3130	regulation of translation
S40542_RS11025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S40542_RS11030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S40542_RS11035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S40542_RS11040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S40542_RS11045	COG0531	amino acid
S40542_RS11045	COG1674	ftsk spoiiie
S40542_RS11055	COG0686	Belongs to the AlaDH PNT family
S40542_RS11060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S40542_RS11075	COG2957	Belongs to the agmatine deiminase family
S40542_RS11080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S40542_RS11085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S40542_RS11135	COG4753	response regulator
S40542_RS11135	COG2207	Transcriptional regulator
S40542_RS11140	COG0745	RESPONSE REGULATOR receiver
S40542_RS11185	COG5000	phosphorelay sensor kinase activity
S40542_RS11190	COG2204	response regulator
S40542_RS11195	COG1136	(ABC) transporter
S40542_RS11195	COG0577	efflux transmembrane transporter activity
S40542_RS11200	COG0577	efflux transmembrane transporter activity
S40542_RS11200	COG1136	(ABC) transporter
S40542_RS11215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S40542_RS11235	COG0515	serine threonine protein kinase
S40542_RS11235	COG2815	serine threonine protein kinase
S40542_RS11255	COG4771	TonB-dependent receptor
S40542_RS11320	COG3038	cytochrome b561
S40542_RS11325	COG0583	DNA-binding transcription factor activity
S40542_RS11335	COG0659	secondary active sulfate transmembrane transporter activity
S40542_RS11340	COG1522	sequence-specific DNA binding
S40542_RS11345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S40542_RS11355	COG0300	oxidoreductase activity
S40542_RS11360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S40542_RS11365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S40542_RS11370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S40542_RS11390	COG1132	(ABC) transporter
S40542_RS11410	COG3706	GGDEF domain
S40542_RS11420	COG4555	ABC transporter
S40542_RS11445	COG2084	Dehydrogenase
S40542_RS11450	COG0386	Belongs to the glutathione peroxidase family
S40542_RS11455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S40542_RS11460	COG0733	neurotransmitter:sodium symporter activity
S40542_RS11470	COG0527	aspartate kinase activity
S40542_RS11475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S40542_RS11500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S40542_RS11510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S40542_RS11515	COG0564	pseudouridine synthase activity
S40542_RS11520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S40542_RS11525	COG2835	tetraacyldisaccharide 4'-kinase activity
S40542_RS11530	COG1663	tetraacyldisaccharide 4'-kinase activity
S40542_RS11535	COG1132	(ABC) transporter
S40542_RS11540	COG2333	competence protein COMEC
S40542_RS11540	COG0658	competence protein
S40542_RS11555	COG0488	(ABC) transporter
S40542_RS11565	COG0116	Belongs to the methyltransferase superfamily
S40542_RS11565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S40542_RS11575	COG0167	dihydroorotate dehydrogenase activity
S40542_RS11580	COG2902	Dehydrogenase
S40542_RS11590	COG4447	cellulose binding
S40542_RS11610	COG0308	aminopeptidase N
S40542_RS11615	COG1757	Na H antiporter
S40542_RS11625	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
S40542_RS11635	COG1956	GAF domain-containing protein
S40542_RS11665	COG0670	Belongs to the BI1 family
S40542_RS11675	COG2923	Belongs to the DsrF TusC family
S40542_RS11685	COG2920	part of a sulfur-relay system
S40542_RS11705	COG4771	TonB-dependent receptor
S40542_RS11730	COG0037	tRNA processing
S40542_RS11740	COG0022	dehydrogenase e1 component
S40542_RS11745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S40542_RS11750	COG2988	succinylglutamate desuccinylase activity
S40542_RS11755	COG0033	Phosphoglucomutase
S40542_RS11760	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
S40542_RS11765	COG0596	Alpha beta hydrolase
S40542_RS11780	COG0716	FMN binding
S40542_RS11785	COG0735	belongs to the Fur family
S40542_RS11790	COG2801	Transposase and inactivated derivatives
S40542_RS11805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S40542_RS12035	COG0045	succinate-CoA ligase (ADP-forming) activity
S40542_RS12040	COG0508	dehydrogenase complex catalyzes the overall conversion of
S40542_RS12045	COG0567	Dehydrogenase, E1 component
S40542_RS12055	COG1053	succinate dehydrogenase
S40542_RS12060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
S40542_RS12075	COG1254	Belongs to the acylphosphatase family
S40542_RS12100	COG2226	methyltransferase
S40542_RS12110	COG3291	Pkd domain containing protein
S40542_RS12115	COG3092	negative regulation of chromosome organization
S40542_RS12120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S40542_RS12125	COG0280	phosphate acetyltransferase
S40542_RS12125	COG0857	belongs to the CobB CobQ family
S40542_RS12140	COG1393	Belongs to the ArsC family
S40542_RS12145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S40542_RS12150	COG1876	peptidase activity
S40542_RS12155	COG0436	Aminotransferase
S40542_RS12175	COG2205	protein histidine kinase activity
S40542_RS12175	COG0784	Response regulator, receiver
S40542_RS12180	COG2203	Gaf domain
S40542_RS12180	COG4251	negative regulation of phosphorylation
S40542_RS12180	COG5001	Diguanylate cyclase
S40542_RS12180	COG3706	GGDEF domain
S40542_RS12185	COG0489	protein tyrosine kinase activity
S40542_RS12190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S40542_RS12190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S40542_RS12200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S40542_RS12200	COG4191	Histidine kinase
S40542_RS12210	COG0084	hydrolase, TatD family'
S40542_RS12220	COG0470	DNA polymerase III
S40542_RS12225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S40542_RS12230	COG2202	Pas domain
S40542_RS12230	COG2200	EAL domain
S40542_RS12230	COG2199	diguanylate cyclase activity
S40542_RS12235	COG0563	adenylate kinase activity
S40542_RS12240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S40542_RS12255	COG1609	Transcriptional regulator
S40542_RS12260	COG0837	glucose binding
S40542_RS12265	COG1609	Transcriptional regulator
S40542_RS12315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
S40542_RS12345	COG3724	N-succinylarginine dihydrolase activity
S40542_RS12365	COG0167	dihydroorotate dehydrogenase activity
S40542_RS12375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S40542_RS12380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S40542_RS12385	COG1845	cytochrome c oxidase, subunit III
S40542_RS12390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S40542_RS12395	COG0109	protoheme IX farnesyltransferase activity
S40542_RS12495	COG0251	oxidation-reduction process
S40542_RS12500	COG0251	oxidation-reduction process
S40542_RS12510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S40542_RS12520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S40542_RS12525	COG0583	DNA-binding transcription factor activity
S40542_RS12540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S40542_RS12580	COG0745	RESPONSE REGULATOR receiver
S40542_RS12585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S40542_RS12625	COG0346	lactoylglutathione lyase activity
S40542_RS12650	COG3710	Transcriptional regulator
S40542_RS12680	COG1506	peptidase
S40542_RS12680	COG0823	Involved in the tonB-independent uptake of proteins
S40542_RS12690	COG2205	protein histidine kinase activity
S40542_RS12725	COG0328	RNA-DNA hybrid ribonuclease activity
S40542_RS12725	COG3341	Caulimovirus viroplasmin
S40542_RS12735	COG1473	amidohydrolase
S40542_RS12765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S40542_RS12820	COG0745	RESPONSE REGULATOR receiver
S40542_RS12830	COG0463	Glycosyl transferase, family 2
S40542_RS12845	COG0346	lactoylglutathione lyase activity
S40542_RS12890	COG1233	COG1233 Phytoene dehydrogenase and related
S40542_RS12905	COG0259	pyridoxamine-phosphate oxidase activity
S40542_RS13010	COG4916	TIR domain
S40542_RS13080	COG2801	Transposase and inactivated derivatives
S40542_RS13085	COG2963	transposase activity
S40542_RS13125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S40542_RS13255	COG2070	2-Nitropropane dioxygenase
S40542_RS13255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S40542_RS13265	COG2192	nodulation
S40542_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS13270	COG3321	synthase
S40542_RS13270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S40542_RS13270	COG0300	oxidoreductase activity
S40542_RS13270	COG0318	PFAM AMP-dependent synthetase and ligase
S40542_RS13295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S40542_RS13305	COG0300	oxidoreductase activity
S40542_RS13310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S40542_RS13315	COG2124	cytochrome p450
S40542_RS13340	COG0789	Transcriptional regulator
S40542_RS13370	COG1280	lysine exporter protein (LysE YggA)
S40542_RS13450	COG1131	(ABC) transporter
S40542_RS13455	COG0454	-acetyltransferase
S40542_RS13460	COG0702	epimerase
S40542_RS13470	COG0277	FAD linked oxidase domain protein
S40542_RS13485	COG0534	Mate efflux family protein
S40542_RS13495	COG0745	RESPONSE REGULATOR receiver
S40542_RS13500	COG3437	response regulator, receiver
S40542_RS13505	COG2205	protein histidine kinase activity
S40542_RS13505	COG3437	response regulator, receiver
S40542_RS13505	COG3850	Histidine kinase
S40542_RS13505	COG4999	Histidine kinase
S40542_RS13510	COG0456	acetyltransferase
S40542_RS13535	COG4206	TonB-dependent receptor
S40542_RS13555	COG0640	Transcriptional regulator
S40542_RS13560	COG0798	PFAM Bile acid sodium symporter
S40542_RS13585	COG0435	Glutathione S-transferase
S40542_RS13590	COG2259	Doxx family
S40542_RS13605	COG0583	DNA-binding transcription factor activity
S40542_RS13615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
S40542_RS13625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S40542_RS13645	COG0840	transmembrane signaling receptor activity
S40542_RS13650	COG4106	trans-aconitate 2-methyltransferase activity
S40542_RS13675	COG0277	FAD linked oxidase domain protein
S40542_RS13675	COG0247	lactate metabolic process
S40542_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS13725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S40542_RS13730	COG0351	phosphomethylpyrimidine kinase
S40542_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS13765	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS13770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S40542_RS13785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S40542_RS13795	COG2030	dehydratase
S40542_RS13805	COG2986	histidine ammonia-lyase
S40542_RS13815	COG1741	Belongs to the pirin family
S40542_RS13825	COG4946	Tricorn protease homolog
S40542_RS13825	COG1506	peptidase
S40542_RS13825	COG0823	Involved in the tonB-independent uptake of proteins
S40542_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS13845	COG1024	Enoyl-CoA hydratase
S40542_RS13850	COG1024	Enoyl-CoA hydratase
S40542_RS13875	COG1960	acyl-CoA dehydrogenase activity
S40542_RS13880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S40542_RS13885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S40542_RS13900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S40542_RS13910	COG0501	Belongs to the peptidase M48B family
S40542_RS13925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S40542_RS13930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S40542_RS13930	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
S40542_RS13950	COG0523	cobalamin synthesis protein
S40542_RS13965	COG1714	RDD family
S40542_RS13970	COG0840	transmembrane signaling receptor activity
S40542_RS13975	COG0596	Alpha beta hydrolase
S40542_RS13980	COG2205	protein histidine kinase activity
S40542_RS13980	COG0784	Response regulator, receiver
S40542_RS13990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S40542_RS14015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S40542_RS14060	COG1234	tRNA 3'-trailer cleavage
S40542_RS14065	COG3961	Belongs to the TPP enzyme family
S40542_RS14070	COG3385	transposase activity
S40542_RS14085	COG0513	Belongs to the DEAD box helicase family
S40542_RS14090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S40542_RS14100	COG0385	Bile acid
S40542_RS14120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S40542_RS14140	COG4206	TonB-dependent receptor
S40542_RS14150	COG0616	signal peptide processing
S40542_RS14160	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS14165	COG1187	pseudouridine synthase activity
S40542_RS14170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S40542_RS14180	COG0009	L-threonylcarbamoyladenylate synthase
S40542_RS14185	COG0613	PHP domain protein
S40542_RS14190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S40542_RS14195	COG0512	Glutamine amidotransferase of anthranilate synthase
S40542_RS14200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S40542_RS14205	COG0135	phosphoribosylanthranilate isomerase activity
S40542_RS14205	COG0134	indole-3-glycerol-phosphate synthase activity
S40542_RS14220	COG0776	regulation of translation
S40542_RS14225	COG2917	probably involved in intracellular septation
S40542_RS14235	COG0733	neurotransmitter:sodium symporter activity
S40542_RS14240	COG2350	Protein conserved in bacteria
S40542_RS14265	COG0628	permease
S40542_RS14270	COG1090	epimerase
S40542_RS14275	COG5001	Diguanylate cyclase
S40542_RS14275	COG3300	MHYT domain
S40542_RS14305	COG3139	Protein of unknown function (DUF1315)
S40542_RS14315	COG1115	amino acid carrier protein
S40542_RS14320	COG2866	Carboxypeptidase
S40542_RS14335	COG2854	intermembrane phospholipid transfer
S40542_RS14350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S40542_RS14355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S40542_RS14365	COG0121	glutamine amidotransferase
S40542_RS14380	COG0488	(ABC) transporter
S40542_RS14395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S40542_RS14405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S40542_RS14410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S40542_RS14420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S40542_RS14425	COG0416	fatty acid biosynthetic process
S40542_RS14430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S40542_RS14435	COG1399	metal-binding, possibly nucleic acid-binding protein
S40542_RS14440	COG0424	maF-like protein
S40542_RS14450	COG0564	pseudouridine synthase activity
S40542_RS14455	COG1530	ribonuclease E activity
S40542_RS14485	COG3081	Nucleoid-associated protein
S40542_RS14490	COG3082	Protein of unknown function (DUF1414)
S40542_RS14495	COG3083	sulfuric ester hydrolase activity
S40542_RS14505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
S40542_RS14515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S40542_RS14555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S40542_RS14560	COG1074	ATP-dependent DNA helicase activity
S40542_RS14565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
S40542_RS14590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S40542_RS14650	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
S40542_RS14655	COG2885	chlorophyll binding
S40542_RS14660	COG0823	Involved in the tonB-independent uptake of proteins
S40542_RS14675	COG0811	peptide transport
S40542_RS14680	COG2255	four-way junction helicase activity
S40542_RS14685	COG0632	four-way junction helicase activity
S40542_RS14690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S40542_RS14695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S40542_RS14700	COG1801	Protein of unknown function DUF72
S40542_RS14705	COG1451	nucleotide metabolic process
S40542_RS14715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S40542_RS14720	COG1420	regulation of RNA biosynthetic process
S40542_RS14725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S40542_RS14735	COG0497	DNA recombination
S40542_RS14740	COG3038	cytochrome b561
S40542_RS14745	COG0493	'glutamate synthase
S40542_RS14750	COG0069	glutamate synthase activity
S40542_RS14750	COG0067	glutamate synthase
S40542_RS14750	COG0070	glutamate synthase
S40542_RS14755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S40542_RS14760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S40542_RS14765	COG2766	serine protein kinase
S40542_RS14770	COG2718	Belongs to the UPF0229 family
S40542_RS14775	COG2719	SpoVR family
S40542_RS14780	COG3706	GGDEF domain
S40542_RS14785	COG2201	protein-glutamate methylesterase activity
S40542_RS14790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S40542_RS14795	COG0326	Molecular chaperone. Has ATPase activity
S40542_RS14825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S40542_RS14835	COG0730	response to heat
S40542_RS14850	COG0583	DNA-binding transcription factor activity
S40542_RS14860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S40542_RS14870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S40542_RS14880	COG3220	belongs to the UPF0276 family
S40542_RS14890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S40542_RS14915	COG0848	biopolymer transport protein
S40542_RS14920	COG0811	peptide transport
S40542_RS14925	COG0811	peptide transport
S40542_RS14960	COG1760	l-serine dehydratase
S40542_RS14965	COG0583	DNA-binding transcription factor activity
S40542_RS14975	COG2252	PERMEase
S40542_RS15025	COG1418	mRNA catabolic process
S40542_RS15030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S40542_RS15035	COG1404	Belongs to the peptidase S8 family
S40542_RS15070	COG0697	spore germination
S40542_RS15120	COG1671	Belongs to the UPF0178 family
S40542_RS15135	COG1515	deoxyribonuclease V activity
S40542_RS15155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S40542_RS15170	COG1794	racemase activity, acting on amino acids and derivatives
S40542_RS15225	COG1136	(ABC) transporter
S40542_RS15235	COG0577	efflux transmembrane transporter activity
S40542_RS15235	COG1136	(ABC) transporter
S40542_RS15240	COG2204	response regulator
S40542_RS15245	COG4191	Histidine kinase
S40542_RS15255	COG1404	Belongs to the peptidase S8 family
S40542_RS15260	COG2319	Wd-40 repeat
S40542_RS15260	COG4249	Peptidase C14 caspase catalytic subunit p20
S40542_RS15320	COG0322	excinuclease ABC activity
S40542_RS15325	COG2197	response regulator
S40542_RS15340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S40542_RS15350	COG0602	queuosine metabolic process
S40542_RS15355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S40542_RS15395	COG0210	DNA helicase
S40542_RS15410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S40542_RS15415	COG0149	triose-phosphate isomerase activity
S40542_RS15420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S40542_RS15425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S40542_RS15430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S40542_RS15435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S40542_RS15440	COG1534	Rna-binding protein
S40542_RS15455	COG0745	RESPONSE REGULATOR receiver
S40542_RS15460	COG2205	protein histidine kinase activity
S40542_RS15465	COG0733	neurotransmitter:sodium symporter activity
S40542_RS15480	COG2153	protein acetylation
S40542_RS15485	COG4326	sporulation control protein
S40542_RS15520	COG0745	RESPONSE REGULATOR receiver
S40542_RS15530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S40542_RS15545	COG2234	aminopeptidase activity
S40542_RS15550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S40542_RS15565	COG3314	Sporulation integral membrane protein YlbJ
S40542_RS15575	COG2716	regulation of RNA biosynthetic process
S40542_RS15580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S40542_RS15585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
S40542_RS15590	COG1381	Involved in DNA repair and RecF pathway recombination
S40542_RS15600	COG0571	ribonuclease III activity
S40542_RS15610	COG0481	GTPase activity
S40542_RS15630	COG1595	DNA-templated transcription, initiation
S40542_RS15635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S40542_RS15645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
S40542_RS15650	COG0354	folic acid binding
S40542_RS15670	COG3099	Belongs to the UPF0263 family
S40542_RS15680	COG1380	Effector of murein hydrolase LrgA
S40542_RS15685	COG1346	cytolysis
S40542_RS15690	COG0668	transmembrane transport
S40542_RS15700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S40542_RS15705	COG2890	protein-(glutamine-N5) methyltransferase activity
S40542_RS15710	COG2840	Smr protein MutS2
S40542_RS15715	COG0745	RESPONSE REGULATOR receiver
S40542_RS15725	COG0450	alkyl hydroperoxide reductase
S40542_RS15735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S40542_RS15745	COG1555	photosystem II stabilization
S40542_RS15745	COG1596	polysaccharide export
S40542_RS15750	COG3141	response to X-ray
S40542_RS15755	COG1448	Aminotransferase
S40542_RS15775	COG0023	Translation Initiation Factor
S40542_RS15785	COG0077	Prephenate dehydratase
S40542_RS15785	COG1605	Chorismate mutase
S40542_RS15790	COG1605	Chorismate mutase
S40542_RS15790	COG0287	Prephenate dehydrogenase
S40542_RS15795	COG0335	large ribosomal subunit rRNA binding
S40542_RS15800	COG0336	Belongs to the RNA methyltransferase TrmD family
S40542_RS15805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S40542_RS15810	COG0228	four-way junction DNA binding
S40542_RS15815	COG4771	TonB-dependent receptor
S40542_RS15820	COG4558	Periplasmic binding protein
S40542_RS15825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S40542_RS15830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S40542_RS15840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S40542_RS15845	COG4137	Cytochrome C assembly protein
S40542_RS15850	COG4536	flavin adenine dinucleotide binding
S40542_RS15860	COG2918	glutathione biosynthetic process
S40542_RS15865	COG4221	oxidoreductase activity
S40542_RS15865	COG3321	synthase
S40542_RS15865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S40542_RS15865	COG0604	alcohol dehydrogenase
S40542_RS15870	COG0542	response to heat
S40542_RS15880	COG0564	pseudouridine synthase activity
S40542_RS15885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S40542_RS15935	COG3275	phosphorelay sensor kinase activity
S40542_RS15940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S40542_RS15945	COG1047	Peptidyl-prolyl cis-trans
S40542_RS15950	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S40542_RS15955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S40542_RS15960	COG0196	riboflavin kinase activity
S40542_RS15965	COG0728	peptidoglycan biosynthetic process
S40542_RS15970	COG0268	Binds directly to 16S ribosomal RNA
S40542_RS15975	COG2201	protein-glutamate methylesterase activity
S40542_RS15990	COG2840	Smr protein MutS2
S40542_RS15995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S40542_RS16015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S40542_RS16030	COG3228	Belongs to the MtfA family
S40542_RS16035	COG1643	Atp-dependent helicase
S40542_RS16070	COG4206	TonB-dependent receptor
S40542_RS16080	COG0417	DNA replication proofreading
S40542_RS16085	COG1199	ATP-dependent helicase activity
S40542_RS16100	COG0123	including yeast histone deacetylase and acetoin utilization protein
S40542_RS16135	COG3710	Transcriptional regulator
S40542_RS16140	COG1231	oxidoreductase activity
S40542_RS16145	COG3961	Belongs to the TPP enzyme family
S40542_RS16160	COG0745	RESPONSE REGULATOR receiver
S40542_RS16165	COG5002	protein histidine kinase activity
S40542_RS16170	COG0534	Mate efflux family protein
S40542_RS16235	COG1051	belongs to the nudix hydrolase family
S40542_RS16235	COG1056	cytidyltransferase-related domain
S40542_RS16250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S40542_RS16255	COG3706	GGDEF domain
S40542_RS16265	COG4191	Histidine kinase
S40542_RS16265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S40542_RS16280	COG0587	DNA-directed DNA polymerase activity
S40542_RS16315	COG1643	Atp-dependent helicase
S40542_RS16335	COG0577	efflux transmembrane transporter activity
S40542_RS16335	COG1136	(ABC) transporter
S40542_RS16340	COG1136	(ABC) transporter
S40542_RS16350	COG0577	efflux transmembrane transporter activity
S40542_RS16350	COG1136	(ABC) transporter
S40542_RS16365	COG0646	methionine synthase
S40542_RS16365	COG1410	methionine synthase
S40542_RS16370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S40542_RS16620	COG0488	(ABC) transporter
S40542_RS16630	COG3766	membrane
S40542_RS16640	COG0754	glutathionylspermidine amidase activity
S40542_RS16650	COG0835	chemotaxis
S40542_RS16650	COG0784	Response regulator, receiver
S40542_RS16730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S40542_RS16745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S40542_RS16750	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
S40542_RS16755	COG1051	belongs to the nudix hydrolase family
S40542_RS16760	COG3066	DNA modification
S40542_RS16770	COG0148	phosphopyruvate hydratase activity
S40542_RS16775	COG0504	CTP synthase activity
S40542_RS16780	COG3956	TIGRFAM MazG family protein
S40542_RS16785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S40542_RS16790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S40542_RS16795	COG3850	Histidine kinase
S40542_RS16795	COG2205	protein histidine kinase activity
S40542_RS16795	COG3437	response regulator, receiver
S40542_RS16795	COG4999	Histidine kinase
S40542_RS16800	COG2154	pterin-4-alpha-carbinolamine dehydratase
S40542_RS16815	COG3768	UPF0283 membrane protein
S40542_RS16820	COG3106	COG3106 Predicted ATPase
S40542_RS16825	COG1983	PspC domain protein
S40542_RS16835	COG1842	Phage shock protein A
S40542_RS16840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S40542_RS16845	COG4166	transmembrane transport
S40542_RS16855	COG4171	peptide transport system, permease
S40542_RS16865	COG4172	Belongs to the ABC transporter superfamily
S40542_RS16870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S40542_RS16875	COG0776	regulation of translation
S40542_RS16880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S40542_RS16885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S40542_RS16890	COG0740	serine-type endopeptidase activity
S40542_RS16895	COG0544	peptidyl-prolyl cis-trans isomerase activity
S40542_RS16925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S40542_RS16940	COG0251	oxidation-reduction process
S40542_RS16945	COG0215	cysteine-tRNA ligase activity
S40542_RS16950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S40542_RS16955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S40542_RS16960	COG1215	transferase activity, transferring glycosyl groups
S40542_RS16970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S40542_RS16975	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S40542_RS16995	COG2204	response regulator
S40542_RS17005	COG1216	Glycosyl transferase, family 2
S40542_RS17035	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S40542_RS17040	COG1286	toxin biosynthetic process
S40542_RS17050	COG0285	dihydrofolate synthase activity
S40542_RS17055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S40542_RS17060	COG0101	tRNA pseudouridine synthase activity
S40542_RS17075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S40542_RS17085	COG1960	acyl-CoA dehydrogenase activity
S40542_RS17095	COG1116	anion transmembrane transporter activity
S40542_RS17165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S40542_RS17170	COG0328	RNA-DNA hybrid ribonuclease activity
S40542_RS17175	COG2226	methyltransferase
S40542_RS17180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S40542_RS17185	COG1388	LysM domain
S40542_RS17185	COG0741	lytic transglycosylase activity
S40542_RS17195	COG0564	pseudouridine synthase activity
S40542_RS17200	COG3098	single-species biofilm formation
S40542_RS17230	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
S40542_RS17240	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S40542_RS17240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S40542_RS17260	COG0729	surface antigen
S40542_RS17270	COG1061	Type III restriction enzyme res subunit
S40542_RS17280	COG0418	dihydroorotase activity
S40542_RS17285	COG5001	Diguanylate cyclase
S40542_RS17285	COG3300	MHYT domain
S40542_RS17290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S40542_RS17295	COG0583	DNA-binding transcription factor activity
S40542_RS17315	COG0625	glutathione transferase activity
S40542_RS17320	COG0583	DNA-binding transcription factor activity
S40542_RS17330	COG2205	protein histidine kinase activity
S40542_RS17335	COG0556	nucleotide-excision repair
S40542_RS17340	COG0534	Mate efflux family protein
S40542_RS17365	COG2200	EAL domain
S40542_RS17365	COG2771	luxR family
S40542_RS17370	COG4657	Part of a membrane complex involved in electron transport
S40542_RS17375	COG2878	Part of a membrane complex involved in electron transport
S40542_RS17380	COG4656	Part of a membrane complex involved in electron transport
S40542_RS17385	COG4658	electron transport chain
S40542_RS17390	COG4659	FMN binding
S40542_RS17395	COG4660	Part of a membrane complex involved in electron transport
S40542_RS17400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S40542_RS17430	COG0840	transmembrane signaling receptor activity
S40542_RS17520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S40542_RS17530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S40542_RS17540	COG1196	nuclear chromosome segregation
S40542_RS17545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S40542_RS17625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
S40542_RS17630	COG2363	Small membrane protein
S40542_RS17640	COG0583	DNA-binding transcription factor activity
S40542_RS17645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S40542_RS17660	COG0784	Response regulator, receiver
S40542_RS17660	COG3437	response regulator, receiver
S40542_RS17665	COG2890	protein-(glutamine-N5) methyltransferase activity
S40542_RS17670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S40542_RS17675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S40542_RS17680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
S40542_RS17685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S40542_RS17695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S40542_RS17700	COG0193	aminoacyl-tRNA hydrolase activity
S40542_RS17705	COG0012	GTP binding
S40542_RS17775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S40542_RS17780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S40542_RS17785	COG1702	phosphate starvation-inducible protein PhoH
S40542_RS17790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S40542_RS17795	COG4535	Mg2 and Co2 transporter CorC
S40542_RS17800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S40542_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS17825	COG0793	Belongs to the peptidase S41A family
S40542_RS17825	COG4946	Tricorn protease homolog
S40542_RS17830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S40542_RS17835	COG0446	pyridine nucleotide-disulphide oxidoreductase
S40542_RS17840	COG3383	formate dehydrogenase (NAD+) activity
S40542_RS17850	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
S40542_RS17850	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
S40542_RS17850	COG0506	proline dehydrogenase activity
S40542_RS17855	COG0814	amino acid
S40542_RS17870	COG1360	Flagellar Motor Protein
S40542_RS17875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S40542_RS17880	COG1722	exodeoxyribonuclease VII activity
S40542_RS17885	COG0142	geranyltranstransferase activity
S40542_RS17890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S40542_RS17905	COG2205	protein histidine kinase activity
S40542_RS17915	COG0745	RESPONSE REGULATOR receiver
S40542_RS17920	COG2205	protein histidine kinase activity
S40542_RS17935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S40542_RS17940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S40542_RS17950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S40542_RS17955	COG2067	long-chain fatty acid transport protein
S40542_RS17965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
S40542_RS17970	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
S40542_RS17985	COG2177	Part of the ABC transporter FtsEX involved in
S40542_RS17990	COG2884	Cell division ATP-binding protein ftsE
S40542_RS17995	COG0552	protein localization to endoplasmic reticulum
S40542_RS18000	COG0742	ribosomal rna small subunit methyltransferase
S40542_RS18005	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S40542_RS18010	COG1610	YqeY-like protein
S40542_RS18025	COG2264	protein methyltransferase activity
S40542_RS18035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
S40542_RS18040	COG0138	bifunctional purine biosynthesis protein purh
S40542_RS18050	COG0151	Belongs to the GarS family
S40542_RS18070	COG0123	including yeast histone deacetylase and acetoin utilization protein
S40542_RS18085	COG1280	lysine exporter protein (LysE YggA)
S40542_RS18100	COG1187	pseudouridine synthase activity
S40542_RS18105	COG0840	transmembrane signaling receptor activity
S40542_RS18125	COG2200	EAL domain
S40542_RS18125	COG2199	diguanylate cyclase activity
S40542_RS18140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S40542_RS18145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S40542_RS18150	COG1862	Preprotein translocase
S40542_RS18155	COG0343	queuine tRNA-ribosyltransferase activity
S40542_RS18160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S40542_RS18165	COG5001	Diguanylate cyclase
S40542_RS18165	COG5002	protein histidine kinase activity
S40542_RS18170	COG0583	DNA-binding transcription factor activity
S40542_RS18175	COG0306	phosphate transporter
S40542_RS18180	COG1392	Phosphate transport regulator
S40542_RS18190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S40542_RS18195	COG0573	inorganic phosphate transmembrane transporter activity
S40542_RS18200	COG0573	inorganic phosphate transmembrane transporter activity
S40542_RS18210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S40542_RS18220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S40542_RS18225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
S40542_RS18235	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S40542_RS18245	COG1388	LysM domain
S40542_RS18245	COG0741	lytic transglycosylase activity
S40542_RS18250	COG1047	Peptidyl-prolyl cis-trans
S40542_RS18295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S40542_RS18300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S40542_RS18305	COG4206	TonB-dependent receptor
S40542_RS18310	COG1666	GTP binding
S40542_RS18320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S40542_RS18325	COG0301	tRNA thio-modification
S40542_RS18325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S40542_RS18335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S40542_RS18350	COG0165	Argininosuccinate lyase
S40542_RS18350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S40542_RS18355	COG0137	argininosuccinate synthase activity
S40542_RS18365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S40542_RS18370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S40542_RS18390	COG1979	alcohol dehydrogenase
S40542_RS18395	COG0583	DNA-binding transcription factor activity
S40542_RS18400	COG0386	Belongs to the glutathione peroxidase family
S40542_RS18405	COG1846	Transcriptional regulator
S40542_RS18410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S40542_RS18425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S40542_RS18465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S40542_RS18480	COG1091	dTDP-4-dehydrorhamnose reductase activity
S40542_RS18485	COG1088	dTDP-glucose 4,6-dehydratase activity
S40542_RS18510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S40542_RS18525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S40542_RS18535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S40542_RS18535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S40542_RS18550	COG0673	inositol 2-dehydrogenase activity
S40542_RS18575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
S40542_RS18590	COG1596	polysaccharide export
S40542_RS18635	COG1216	Glycosyl transferase, family 2
S40542_RS18645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S40542_RS18650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S40542_RS18670	COG0668	transmembrane transport
S40542_RS18695	COG0494	nUDIX hydrolase
S40542_RS18700	COG0653	protein targeting
S40542_RS18710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
S40542_RS18715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S40542_RS18720	COG0849	cell division
S40542_RS18725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S40542_RS18730	COG1181	Belongs to the D-alanine--D-alanine ligase family
S40542_RS18735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S40542_RS18740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S40542_RS18745	COG0772	Belongs to the SEDS family
S40542_RS18750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S40542_RS18755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S40542_RS18760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S40542_RS18765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S40542_RS18770	COG0768	penicillin binding
S40542_RS18775	COG3116	cell division
S40542_RS18780	COG0275	rRNA processing
S40542_RS18785	COG2001	Belongs to the MraZ family
S40542_RS18795	COG1785	Belongs to the alkaline phosphatase family
S40542_RS18805	COG2197	response regulator
S40542_RS18825	COG2226	methyltransferase
S40542_RS18835	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
S40542_RS18875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S40542_RS18880	COG3107	peptidoglycan biosynthetic process
S40542_RS18885	COG0792	nuclease activity
S40542_RS18895	COG2823	Periplasmic or secreted lipoprotein
S40542_RS18900	COG2969	positive regulation of protein catabolic process
S40542_RS18905	COG0625	glutathione transferase activity
S40542_RS18910	COG2857	Cytochrome c1
S40542_RS18915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S40542_RS18920	COG0723	plastoquinol--plastocyanin reductase activity
S40542_RS18935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S40542_RS18940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S40542_RS18945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
S40542_RS18965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S40542_RS18970	COG5007	Belongs to the BolA IbaG family
S40542_RS18975	COG3113	response to antibiotic
S40542_RS18980	COG2854	intermembrane phospholipid transfer
S40542_RS18985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S40542_RS18990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S40542_RS18995	COG1127	ABC transporter
S40542_RS19010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
S40542_RS19025	COG1137	ATPase activity
S40542_RS19030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S40542_RS19035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S40542_RS19045	COG1660	Displays ATPase and GTPase activities
S40542_RS19050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S40542_RS19055	COG2239	Acts as a magnesium transporter
S40542_RS19060	COG0312	modulator of DNA gyrase
S40542_RS19070	COG0312	modulator of DNA gyrase
S40542_RS19075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S40542_RS19080	COG3164	Protein of unknown function
S40542_RS19085	COG1530	ribonuclease E activity
S40542_RS19090	COG0424	maF-like protein
S40542_RS19095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S40542_RS19100	COG1792	Involved in formation and maintenance of cell shape
S40542_RS19105	COG1077	Cell shape determining protein MreB Mrl
S40542_RS19115	COG2515	1-aminocyclopropane-1-carboxylate deaminase
S40542_RS19125	COG0629	single-stranded DNA binding
S40542_RS19130	COG2814	Major facilitator Superfamily
S40542_RS19140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S40542_RS19180	COG2031	fatty acid transporter
S40542_RS19190	COG2203	Gaf domain
S40542_RS19190	COG3706	GGDEF domain
S40542_RS19190	COG4251	negative regulation of phosphorylation
S40542_RS19190	COG5001	Diguanylate cyclase
S40542_RS19195	COG1253	flavin adenine dinucleotide binding
S40542_RS19210	COG0606	chelatase, subunit chli
S40542_RS19240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S40542_RS19250	COG1227	inorganic diphosphatase activity
S40542_RS19255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S40542_RS19260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S40542_RS19265	COG2003	Belongs to the UPF0758 family
S40542_RS19270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S40542_RS19275	COG1309	transcriptional regulator
S40542_RS19285	COG1032	radical SAM domain protein
S40542_RS19330	COG1842	Phage shock protein A
S40542_RS19345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S40542_RS19355	COG3954	Phosphoribulokinase
S40542_RS19360	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
S40542_RS19365	COG1011	Hydrolase
S40542_RS19370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S40542_RS19375	COG0557	exoribonuclease II activity
S40542_RS19395	COG2197	response regulator
S40542_RS19400	COG4585	Histidine kinase
S40542_RS19410	COG0584	glycerophosphoryl diester phosphodiesterase
S40542_RS19420	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
S40542_RS19425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S40542_RS19465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S40542_RS19510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S40542_RS19515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S40542_RS19520	COG0049	tRNA binding
S40542_RS19525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S40542_RS19530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S40542_RS19535	COG0085	RNA polymerase activity
S40542_RS19540	COG0222	ribosome binding
S40542_RS19545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S40542_RS19550	COG0081	regulation of translation
S40542_RS19555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S40542_RS19560	COG0250	Participates in transcription elongation, termination and antitermination
S40542_RS19565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S40542_RS19580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S40542_RS19580	COG1648	precorrin-2 dehydrogenase activity
S40542_RS19585	COG0175	sulfate reduction
S40542_RS19590	COG2895	sulfate adenylyltransferase (ATP) activity
S40542_RS19595	COG0471	metal ion transport
S40542_RS19595	COG3273	potassium ion transport
S40542_RS19600	COG0529	Catalyzes the synthesis of activated sulfate
S40542_RS19605	COG1218	3'(2'),5'-bisphosphate nucleotidase
S40542_RS19615	COG0456	acetyltransferase
S40542_RS19625	COG1490	D-aminoacyl-tRNA deacylase activity
S40542_RS19635	COG1295	ribonuclease BN
S40542_RS19655	COG1840	ABC-type Fe3 transport system, periplasmic component
S40542_RS19665	COG2501	S4 domain
S40542_RS19670	COG2050	protein possibly involved in aromatic compounds catabolism
S40542_RS19690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S40542_RS19695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S40542_RS19700	COG2356	endonuclease I
S40542_RS19745	COG1169	isochorismate synthase
S40542_RS19750	COG1021	2,3-dihydroxybenzoate-AMP ligase
S40542_RS19755	COG3433	isochorismatase activity
S40542_RS19755	COG1535	isochorismatase
S40542_RS19760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S40542_RS19765	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS19820	COG3251	PFAM MbtH domain protein
S40542_RS19825	COG2366	antibiotic biosynthetic process
S40542_RS19850	COG0066	3-isopropylmalate dehydratase activity
S40542_RS19855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S40542_RS19860	COG0473	3-isopropylmalate dehydrogenase activity
S40542_RS19865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S40542_RS19915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S40542_RS19930	COG1082	Xylose isomerase domain protein TIM barrel
S40542_RS19940	COG2207	Transcriptional regulator
S40542_RS19950	COG4977	sequence-specific DNA binding
S40542_RS19980	COG2932	Transcriptional regulator
S40542_RS20025	COG0248	Ppx GppA phosphatase
S40542_RS20035	COG3118	belongs to the thioredoxin family
S40542_RS20045	COG0840	transmembrane signaling receptor activity
S40542_RS20050	COG2205	protein histidine kinase activity
S40542_RS20050	COG0784	Response regulator, receiver
S40542_RS20060	COG0513	Belongs to the DEAD box helicase family
S40542_RS20080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S40542_RS20090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S40542_RS20090	COG0517	IMP dehydrogenase activity
S40542_RS20090	COG0617	tRNA 3'-terminal CCA addition
S40542_RS20095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S40542_RS20110	COG0181	hydroxymethylbilane synthase activity
S40542_RS20125	COG1965	Belongs to the frataxin family
S40542_RS20135	COG0019	diaminopimelate decarboxylase activity
S40542_RS20140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S40542_RS20150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S40542_RS20155	COG1011	Hydrolase
S40542_RS20185	COG1187	pseudouridine synthase activity
S40542_RS20200	COG3706	GGDEF domain
S40542_RS20210	COG2205	protein histidine kinase activity
S40542_RS20210	COG5002	protein histidine kinase activity
S40542_RS20210	COG0784	Response regulator, receiver
S40542_RS20215	COG3132	Protein of unknown function, DUF480
S40542_RS20220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S40542_RS20230	COG0302	gtp cyclohydrolase
S40542_RS20235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S40542_RS20255	COG1404	Belongs to the peptidase S8 family
S40542_RS20275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S40542_RS20285	COG1597	lipid kinase activity
S40542_RS20305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S40542_RS20315	COG1522	sequence-specific DNA binding
S40542_RS20320	COG0784	Response regulator, receiver
S40542_RS20320	COG2205	protein histidine kinase activity
S40542_RS20360	COG3321	synthase
S40542_RS20360	COG0604	alcohol dehydrogenase
S40542_RS20365	COG0583	DNA-binding transcription factor activity
S40542_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
S40542_RS20380	COG2207	Transcriptional regulator
S40542_RS20390	COG0840	transmembrane signaling receptor activity
S40542_RS20405	COG2832	Protein of unknown function (DUF454)
S40542_RS20415	COG1595	DNA-templated transcription, initiation
S40542_RS20460	COG0848	biopolymer transport protein
S40542_RS20475	COG1396	sequence-specific DNA binding
S40542_RS20505	COG1396	sequence-specific DNA binding
S40542_RS20510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S40542_RS20515	COG1349	DNA-binding transcription factor activity
S40542_RS20525	COG0577	efflux transmembrane transporter activity
S40542_RS20525	COG1136	(ABC) transporter
S40542_RS20530	COG1136	(ABC) transporter
S40542_RS20530	COG0577	efflux transmembrane transporter activity
S40542_RS20545	COG4191	Histidine kinase
S40542_RS20565	COG1388	LysM domain
S40542_RS20565	COG0741	lytic transglycosylase activity
S40542_RS20610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S40542_RS20665	COG3710	Transcriptional regulator
S40542_RS20670	COG2771	luxR family
S40542_RS20685	COG3710	Transcriptional regulator
S40542_RS20690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S40542_RS20700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S40542_RS20705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S40542_RS20710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S40542_RS20715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S40542_RS20725	COG0356	it plays a direct role in the translocation of protons across the membrane
S40542_RS20735	COG1475	DNA binding
S40542_RS20740	COG1192	Involved in chromosome partitioning
S40542_RS20745	COG0357	Ribosomal RNA small subunit methyltransferase G
S40542_RS20750	COG0445	tRNA wobble uridine modification
S40542_RS20755	COG0716	FMN binding
S40542_RS20760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S40542_RS20780	COG4232	protein-disulfide reductase activity
S40542_RS20785	COG0706	membrane insertase activity
S40542_RS20790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S40542_RS20795	COG0594	ribonuclease P activity
S40542_RS21170	COG2226	methyltransferase
S40542_RS21690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S40542_RS21850	COG2937	Belongs to the GPAT DAPAT family
S40542_RS21925	COG2200	EAL domain
S40542_RS21955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S40542_RS22125	COG0288	reversible hydration of carbon dioxide
S40542_RS22525	COG0459	protein refolding
S40542_RS22615	COG0840	transmembrane signaling receptor activity
S40542_RS22720	COG0348	domain, Protein
S40542_RS22930	COG1570	exodeoxyribonuclease VII activity
S40542_RS22935	COG0517	IMP dehydrogenase activity
S40542_RS22935	COG0516	GMP reductase activity
S40542_RS22990	COG0018	arginyl-trna synthetase
S40542_RS23070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S40542_RS23190	COG4191	Histidine kinase
S40542_RS23780	COG4191	Histidine kinase
S40542_RS24005	COG0842	Transport permease protein
S40542_RS24530	COG0860	N-Acetylmuramoyl-L-alanine amidase
S40542_RS24620	COG4948	Mandelate Racemase Muconate Lactonizing
S40542_RS24710	COG0514	ATP-dependent DNA helicase (RecQ)
S40542_RS24950	COG0784	Response regulator, receiver
S40542_RS24950	COG3437	response regulator, receiver
S40542_RS24980	COG1968	undecaprenyl-diphosphatase activity
S40542_RS25080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S40542_RS25180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S40542_RS25690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane