locus-tag	class	description
CWC22_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWC22_RS00020	COG0187	DNA topoisomerase II activity
CWC22_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
CWC22_RS00030	COG0751	glycine-tRNA ligase activity
CWC22_RS00040	COG0425	Belongs to the sulfur carrier protein TusA family
CWC22_RS00045	COG0183	Belongs to the thiolase family
CWC22_RS00050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWC22_RS00050	COG1024	Enoyl-CoA hydratase
CWC22_RS00060	COG0006	proline dipeptidase activity
CWC22_RS00065	COG1739	Uncharacterized protein family UPF0029
CWC22_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWC22_RS00090	COG0569	domain protein
CWC22_RS00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWC22_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWC22_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWC22_RS00105	COG0242	peptide deformylase activity
CWC22_RS00115	COG0758	DNA mediated transformation
CWC22_RS00120	COG2922	Belongs to the Smg family
CWC22_RS00130	COG0009	L-threonylcarbamoyladenylate synthase
CWC22_RS00135	COG0408	coproporphyrinogen oxidase activity
CWC22_RS00150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWC22_RS00160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CWC22_RS00235	COG2205	protein histidine kinase activity
CWC22_RS00235	COG0784	Response regulator, receiver
CWC22_RS00240	COG1522	sequence-specific DNA binding
CWC22_RS00250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWC22_RS00300	COG4584	PFAM Integrase catalytic
CWC22_RS00305	COG1484	DNA-dependent DNA replication
CWC22_RS00315	COG4974	Belongs to the 'phage' integrase family
CWC22_RS00380	COG1132	(ABC) transporter
CWC22_RS00385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWC22_RS00390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWC22_RS00415	COG1597	lipid kinase activity
CWC22_RS00425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC22_RS00445	COG1404	Belongs to the peptidase S8 family
CWC22_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWC22_RS00470	COG0302	gtp cyclohydrolase
CWC22_RS00480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWC22_RS00485	COG3132	Protein of unknown function, DUF480
CWC22_RS00500	COG3706	GGDEF domain
CWC22_RS00510	COG1187	pseudouridine synthase activity
CWC22_RS00530	COG1011	Hydrolase
CWC22_RS00535	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CWC22_RS00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWC22_RS00550	COG0019	diaminopimelate decarboxylase activity
CWC22_RS00560	COG1965	Belongs to the frataxin family
CWC22_RS00565	COG0400	carboxylic ester hydrolase activity
CWC22_RS00575	COG0181	hydroxymethylbilane synthase activity
CWC22_RS00590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CWC22_RS00595	COG0617	tRNA 3'-terminal CCA addition
CWC22_RS00595	COG0517	IMP dehydrogenase activity
CWC22_RS00595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CWC22_RS00605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CWC22_RS00625	COG0513	Belongs to the DEAD box helicase family
CWC22_RS00635	COG2205	protein histidine kinase activity
CWC22_RS00635	COG0784	Response regulator, receiver
CWC22_RS00640	COG0840	transmembrane signaling receptor activity
CWC22_RS00650	COG3118	belongs to the thioredoxin family
CWC22_RS00655	COG0513	Belongs to the DEAD box helicase family
CWC22_RS00660	COG0248	Ppx GppA phosphatase
CWC22_RS00700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CWC22_RS00705	COG1132	(ABC) transporter
CWC22_RS00740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWC22_RS00755	COG2204	response regulator
CWC22_RS00760	COG3852	Histidine kinase
CWC22_RS00770	COG0174	glutamine synthetase
CWC22_RS00775	COG1217	gtp-binding protein TYPA
CWC22_RS00790	COG1444	tRNA N-acetyltransferase activity
CWC22_RS00795	COG0210	DNA helicase
CWC22_RS00800	COG0835	chemotaxis
CWC22_RS00800	COG0784	Response regulator, receiver
CWC22_RS00820	COG1946	Acyl-CoA thioesterase
CWC22_RS00825	COG2937	Belongs to the GPAT DAPAT family
CWC22_RS00830	COG0051	transcription antitermination factor activity, RNA binding
CWC22_RS00835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWC22_RS00840	COG0088	Forms part of the polypeptide exit tunnel
CWC22_RS00845	COG0089	rRNA binding
CWC22_RS00850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWC22_RS00855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWC22_RS00860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWC22_RS00865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWC22_RS00870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWC22_RS00875	COG0255	Belongs to the universal ribosomal protein uL29 family
CWC22_RS00880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWC22_RS00895	COG0840	transmembrane signaling receptor activity
CWC22_RS00915	COG1228	amidohydrolase
CWC22_RS00925	COG0010	Belongs to the arginase family
CWC22_RS00930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CWC22_RS00935	COG0671	phosphoesterase, PA-phosphatase related
CWC22_RS00955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CWC22_RS00960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CWC22_RS00965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CWC22_RS00970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWC22_RS00975	COG0254	rRNA binding
CWC22_RS00980	COG0281	malic enzyme
CWC22_RS00985	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CWC22_RS00990	COG0626	cystathionine gamma-synthase activity
CWC22_RS00995	COG0460	homoserine dehydrogenase
CWC22_RS00995	COG0527	aspartate kinase activity
CWC22_RS01000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CWC22_RS01030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWC22_RS01035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWC22_RS01045	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CWC22_RS01060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWC22_RS01070	COG0180	Tryptophanyl-tRNA synthetase
CWC22_RS01075	COG2932	Transcriptional regulator
CWC22_RS01085	COG2207	Transcriptional regulator
CWC22_RS01095	COG1082	Xylose isomerase domain protein TIM barrel
CWC22_RS01110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWC22_RS01135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWC22_RS01140	COG3138	arginine N-succinyltransferase
CWC22_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
CWC22_RS01155	COG1765	OsmC-like protein
CWC22_RS01160	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWC22_RS01180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CWC22_RS01195	COG2022	thiamine diphosphate biosynthetic process
CWC22_RS01205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWC22_RS01215	COG0688	phosphatidylethanolamine metabolic process
CWC22_RS01220	COG1162	GTPase activity
CWC22_RS01225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CWC22_RS01255	COG0360	Binds together with S18 to 16S ribosomal RNA
CWC22_RS01260	COG2965	DNA replication, synthesis of RNA primer
CWC22_RS01265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWC22_RS01270	COG0359	binds to the 23S rRNA
CWC22_RS01315	COG0305	Participates in initiation and elongation during chromosome replication
CWC22_RS01325	COG0432	Pfam Uncharacterised protein family UPF0047
CWC22_RS01335	COG0735	belongs to the Fur family
CWC22_RS01345	COG0442	prolyl-tRNA aminoacylation
CWC22_RS01360	COG0662	Cupin 2, conserved barrel domain protein
CWC22_RS01365	COG1218	3'(2'),5'-bisphosphate nucleotidase
CWC22_RS01370	COG0529	Catalyzes the synthesis of activated sulfate
CWC22_RS01375	COG0471	metal ion transport
CWC22_RS01375	COG3273	potassium ion transport
CWC22_RS01380	COG2895	sulfate adenylyltransferase (ATP) activity
CWC22_RS01385	COG0175	sulfate reduction
CWC22_RS01390	COG1648	precorrin-2 dehydrogenase activity
CWC22_RS01390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWC22_RS01395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWC22_RS01410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWC22_RS01420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWC22_RS01425	COG0081	regulation of translation
CWC22_RS01430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWC22_RS01435	COG0222	ribosome binding
CWC22_RS01440	COG0085	RNA polymerase activity
CWC22_RS01445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWC22_RS01450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWC22_RS01455	COG0049	tRNA binding
CWC22_RS01460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWC22_RS01465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWC22_RS01500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWC22_RS01510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWC22_RS01515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CWC22_RS01545	COG0109	protoheme IX farnesyltransferase activity
CWC22_RS01550	COG1999	signal sequence binding
CWC22_RS01565	COG0745	RESPONSE REGULATOR receiver
CWC22_RS01570	COG2198	Histidine kinase
CWC22_RS01570	COG0643	Histidine kinase
CWC22_RS01575	COG0835	chemotaxis
CWC22_RS01590	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CWC22_RS01595	COG2201	protein-glutamate methylesterase activity
CWC22_RS01605	COG0534	Mate efflux family protein
CWC22_RS01615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CWC22_RS01615	COG0316	Belongs to the HesB IscA family
CWC22_RS01625	COG1040	competence protein
CWC22_RS01630	COG0596	Alpha beta hydrolase
CWC22_RS01645	COG2183	response to ionizing radiation
CWC22_RS01650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWC22_RS01670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CWC22_RS01675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWC22_RS01685	COG3031	protein transport across the cell outer membrane
CWC22_RS01695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWC22_RS01700	COG1459	type II secretion system
CWC22_RS01705	COG2165	general secretion pathway protein
CWC22_RS01715	COG2165	general secretion pathway protein
CWC22_RS01760	COG0348	domain, Protein
CWC22_RS01765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CWC22_RS01770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWC22_RS01780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWC22_RS01790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWC22_RS01800	COG0724	RNA recognition motif
CWC22_RS01830	COG0606	chelatase, subunit chli
CWC22_RS01840	COG1506	peptidase
CWC22_RS01840	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS01845	COG5001	Diguanylate cyclase
CWC22_RS01845	COG4251	negative regulation of phosphorylation
CWC22_RS01845	COG3706	GGDEF domain
CWC22_RS01845	COG2203	Gaf domain
CWC22_RS01855	COG2031	fatty acid transporter
CWC22_RS01870	COG3112	Uncharacterised protein family (UPF0231)
CWC22_RS01890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWC22_RS01900	COG2814	Major facilitator Superfamily
CWC22_RS01905	COG0629	single-stranded DNA binding
CWC22_RS01930	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CWC22_RS01940	COG1077	Cell shape determining protein MreB Mrl
CWC22_RS01945	COG1792	Involved in formation and maintenance of cell shape
CWC22_RS01950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CWC22_RS01955	COG0424	maF-like protein
CWC22_RS01960	COG1530	ribonuclease E activity
CWC22_RS01965	COG3164	Protein of unknown function
CWC22_RS01970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWC22_RS01975	COG0312	modulator of DNA gyrase
CWC22_RS01985	COG0312	modulator of DNA gyrase
CWC22_RS01990	COG2239	Acts as a magnesium transporter
CWC22_RS01995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC22_RS02000	COG1660	Displays ATPase and GTPase activities
CWC22_RS02005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWC22_RS02010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWC22_RS02015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWC22_RS02020	COG1137	ATPase activity
CWC22_RS02035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CWC22_RS02050	COG1127	ABC transporter
CWC22_RS02055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CWC22_RS02060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CWC22_RS02065	COG2854	intermembrane phospholipid transfer
CWC22_RS02070	COG3113	response to antibiotic
CWC22_RS02075	COG5007	Belongs to the BolA IbaG family
CWC22_RS02080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWC22_RS02090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWC22_RS02100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CWC22_RS02105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWC22_RS02110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWC22_RS02115	COG0723	plastoquinol--plastocyanin reductase activity
CWC22_RS02120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CWC22_RS02125	COG2857	Cytochrome c1
CWC22_RS02130	COG0625	glutathione transferase activity
CWC22_RS02135	COG2969	positive regulation of protein catabolic process
CWC22_RS02140	COG2823	Periplasmic or secreted lipoprotein
CWC22_RS02150	COG0792	nuclease activity
CWC22_RS02155	COG3107	peptidoglycan biosynthetic process
CWC22_RS02160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CWC22_RS02180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWC22_RS02185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWC22_RS02190	COG0745	RESPONSE REGULATOR receiver
CWC22_RS02225	COG1476	TRANSCRIPTIONal
CWC22_RS02265	COG0583	DNA-binding transcription factor activity
CWC22_RS02285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CWC22_RS02330	COG4181	ATPase activity
CWC22_RS02335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWC22_RS02375	COG0859	PFAM glycosyl transferase family 9
CWC22_RS02385	COG1940	carbohydrate kinase activity
CWC22_RS02385	COG1846	Transcriptional regulator
CWC22_RS02395	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWC22_RS02425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CWC22_RS02465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWC22_RS02470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWC22_RS02480	COG0137	argininosuccinate synthase activity
CWC22_RS02485	COG0165	Argininosuccinate lyase
CWC22_RS02485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CWC22_RS02500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWC22_RS02510	COG0301	tRNA thio-modification
CWC22_RS02510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWC22_RS02525	COG3961	Belongs to the TPP enzyme family
CWC22_RS02530	COG1231	oxidoreductase activity
CWC22_RS02550	COG1666	GTP binding
CWC22_RS02555	COG4206	TonB-dependent receptor
CWC22_RS02565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS02570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC22_RS02610	COG1047	Peptidyl-prolyl cis-trans
CWC22_RS02615	COG1388	LysM domain
CWC22_RS02615	COG0741	lytic transglycosylase activity
CWC22_RS02625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CWC22_RS02635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CWC22_RS02645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CWC22_RS02650	COG0248	Ppx GppA phosphatase
CWC22_RS02665	COG0573	inorganic phosphate transmembrane transporter activity
CWC22_RS02670	COG0573	inorganic phosphate transmembrane transporter activity
CWC22_RS02675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWC22_RS02680	COG0704	Plays a role in the regulation of phosphate uptake
CWC22_RS02690	COG1392	Phosphate transport regulator
CWC22_RS02695	COG0306	phosphate transporter
CWC22_RS02700	COG0583	DNA-binding transcription factor activity
CWC22_RS02705	COG5001	Diguanylate cyclase
CWC22_RS02705	COG5002	protein histidine kinase activity
CWC22_RS02710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWC22_RS02715	COG0343	queuine tRNA-ribosyltransferase activity
CWC22_RS02720	COG1862	Preprotein translocase
CWC22_RS02725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWC22_RS02730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWC22_RS02760	COG0840	transmembrane signaling receptor activity
CWC22_RS02765	COG1187	pseudouridine synthase activity
CWC22_RS02780	COG1280	lysine exporter protein (LysE YggA)
CWC22_RS02795	COG0123	including yeast histone deacetylase and acetoin utilization protein
CWC22_RS02815	COG0151	Belongs to the GarS family
CWC22_RS02825	COG0138	bifunctional purine biosynthesis protein purh
CWC22_RS02830	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CWC22_RS02835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWC22_RS02840	COG2264	protein methyltransferase activity
CWC22_RS02850	COG0358	DNA primase activity
CWC22_RS02855	COG1610	YqeY-like protein
CWC22_RS02860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWC22_RS02865	COG0742	ribosomal rna small subunit methyltransferase
CWC22_RS02870	COG0552	protein localization to endoplasmic reticulum
CWC22_RS02875	COG2884	Cell division ATP-binding protein ftsE
CWC22_RS02880	COG2177	Part of the ABC transporter FtsEX involved in
CWC22_RS02890	COG0204	Acyl-transferase
CWC22_RS02895	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CWC22_RS02900	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWC22_RS02910	COG2067	long-chain fatty acid transport protein
CWC22_RS02915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWC22_RS02960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWC22_RS02975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWC22_RS02980	COG1846	Transcriptional regulator
CWC22_RS02985	COG0386	Belongs to the glutathione peroxidase family
CWC22_RS02990	COG0583	DNA-binding transcription factor activity
CWC22_RS02995	COG1979	alcohol dehydrogenase
CWC22_RS03015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWC22_RS03025	COG0788	formyltetrahydrofolate deformylase activity
CWC22_RS03040	COG1469	GTP cyclohydrolase I activity
CWC22_RS03045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWC22_RS03050	COG0339	signal peptide processing
CWC22_RS03060	COG0523	cobalamin synthesis protein
CWC22_RS03100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWC22_RS03105	COG0339	signal peptide processing
CWC22_RS03115	COG0742	ribosomal rna small subunit methyltransferase
CWC22_RS03130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWC22_RS03130	COG3153	acetyltransferase
CWC22_RS03145	COG0784	Response regulator, receiver
CWC22_RS03145	COG2205	protein histidine kinase activity
CWC22_RS03150	COG0525	valine-tRNA ligase activity
CWC22_RS03155	COG2927	DNA polymerase III (CHI subunit)
CWC22_RS03160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWC22_RS03165	COG0795	lipopolysaccharide-transporting ATPase activity
CWC22_RS03170	COG0795	lipopolysaccharide-transporting ATPase activity
CWC22_RS03190	COG2200	EAL domain
CWC22_RS03195	COG2233	PERMEase
CWC22_RS03200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWC22_RS03230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS03240	COG4191	Histidine kinase
CWC22_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC22_RS03250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWC22_RS03255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWC22_RS03265	COG0762	integral membrane protein
CWC22_RS03270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWC22_RS03275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWC22_RS03295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWC22_RS03300	COG1678	Uncharacterized ACR, COG1678
CWC22_RS03305	COG0189	ligase activity
CWC22_RS03310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWC22_RS03325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CWC22_RS03335	COG1560	Kdo2-lipid A biosynthetic process
CWC22_RS03340	COG1538	Outer membrane efflux protein
CWC22_RS03345	COG0494	nUDIX hydrolase
CWC22_RS03350	COG3151	Protein conserved in bacteria
CWC22_RS03360	COG3150	esterase
CWC22_RS03365	COG0187	DNA topoisomerase II activity
CWC22_RS03370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWC22_RS03385	COG0745	RESPONSE REGULATOR receiver
CWC22_RS03395	COG0583	DNA-binding transcription factor activity
CWC22_RS03400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC22_RS03435	COG2066	Belongs to the glutaminase family
CWC22_RS03440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC22_RS03455	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CWC22_RS03460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWC22_RS03460	COG0047	phosphoribosylformylglycinamidine synthase activity
CWC22_RS03480	COG3784	Protein of unknown function (DUF1318)
CWC22_RS03490	COG1519	Transferase
CWC22_RS03500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CWC22_RS03505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWC22_RS03505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CWC22_RS03510	COG3642	lipopolysaccharide core region biosynthetic process
CWC22_RS03515	COG0859	PFAM glycosyl transferase family 9
CWC22_RS03520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CWC22_RS03525	COG0156	8-amino-7-oxononanoate synthase activity
CWC22_RS03530	COG1063	alcohol dehydrogenase
CWC22_RS03535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWC22_RS03540	COG0705	Rhomboid family
CWC22_RS03545	COG1580	Controls the rotational direction of flagella during chemotaxis
CWC22_RS03550	COG3161	chorismate lyase activity
CWC22_RS03555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CWC22_RS03560	COG0583	DNA-binding transcription factor activity
CWC22_RS03565	COG3437	response regulator, receiver
CWC22_RS03565	COG0784	Response regulator, receiver
CWC22_RS03585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWC22_RS03590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWC22_RS03600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWC22_RS03600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWC22_RS03605	COG1968	undecaprenyl-diphosphatase activity
CWC22_RS03620	COG3148	PFAM DTW domain containing protein
CWC22_RS03625	COG1840	ABC-type Fe3 transport system, periplasmic component
CWC22_RS03635	COG3842	ATPase activity
CWC22_RS03645	COG1438	arginine binding
CWC22_RS03650	COG0039	L-malate dehydrogenase activity
CWC22_RS03655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC22_RS03665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWC22_RS03680	COG3706	GGDEF domain
CWC22_RS03690	COG0004	ammonium transporteR
CWC22_RS03695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWC22_RS03705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWC22_RS03710	COG0540	Belongs to the ATCase OTCase family
CWC22_RS03715	COG1981	membrane
CWC22_RS03725	COG0316	Belongs to the HesB IscA family
CWC22_RS03740	COG2807	transmembrane transport
CWC22_RS03755	COG2813	Specifically methylates the guanine in position
CWC22_RS03765	COG0271	Belongs to the BolA IbaG family
CWC22_RS03770	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CWC22_RS03775	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CWC22_RS03780	COG1805	sodium ion transport
CWC22_RS03785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CWC22_RS03790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CWC22_RS03795	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CWC22_RS03800	COG2871	sodium ion transport
CWC22_RS03805	COG1477	protein flavinylation
CWC22_RS03820	COG1120	ATPase activity
CWC22_RS03825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWC22_RS03830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CWC22_RS03835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CWC22_RS03845	COG1492	cobalamin metabolic process
CWC22_RS03855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWC22_RS03860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWC22_RS03875	COG3022	response to hydroperoxide
CWC22_RS03885	COG2814	Major facilitator Superfamily
CWC22_RS03895	COG0513	Belongs to the DEAD box helicase family
CWC22_RS03900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWC22_RS03965	COG0813	purine-nucleoside phosphorylase activity
CWC22_RS03975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWC22_RS03980	COG0142	geranyltranstransferase activity
CWC22_RS03985	COG1722	exodeoxyribonuclease VII activity
CWC22_RS03990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CWC22_RS04010	COG0814	amino acid
CWC22_RS04015	COG0506	proline dehydrogenase activity
CWC22_RS04015	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CWC22_RS04015	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CWC22_RS04025	COG4946	Tricorn protease homolog
CWC22_RS04025	COG0793	Belongs to the peptidase S41A family
CWC22_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS04100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CWC22_RS04105	COG4535	Mg2 and Co2 transporter CorC
CWC22_RS04110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWC22_RS04115	COG1702	phosphate starvation-inducible protein PhoH
CWC22_RS04120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWC22_RS04125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC22_RS04190	COG0012	GTP binding
CWC22_RS04195	COG0193	aminoacyl-tRNA hydrolase activity
CWC22_RS04200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWC22_RS04205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CWC22_RS04210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWC22_RS04215	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CWC22_RS04220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWC22_RS04225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWC22_RS04230	COG2890	protein-(glutamine-N5) methyltransferase activity
CWC22_RS04235	COG0784	Response regulator, receiver
CWC22_RS04235	COG3437	response regulator, receiver
CWC22_RS04255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CWC22_RS04260	COG0583	DNA-binding transcription factor activity
CWC22_RS04270	COG2363	Small membrane protein
CWC22_RS04275	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CWC22_RS04300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CWC22_RS04320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWC22_RS04325	COG1196	nuclear chromosome segregation
CWC22_RS04335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWC22_RS04345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWC22_RS04445	COG0523	cobalamin synthesis protein
CWC22_RS04450	COG1620	l-lactate permease
CWC22_RS04460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWC22_RS04465	COG4660	Part of a membrane complex involved in electron transport
CWC22_RS04470	COG4659	FMN binding
CWC22_RS04480	COG4656	Part of a membrane complex involved in electron transport
CWC22_RS04485	COG2878	Part of a membrane complex involved in electron transport
CWC22_RS04490	COG4657	Part of a membrane complex involved in electron transport
CWC22_RS04495	COG2771	luxR family
CWC22_RS04495	COG2200	EAL domain
CWC22_RS04520	COG0534	Mate efflux family protein
CWC22_RS04525	COG0556	nucleotide-excision repair
CWC22_RS04535	COG0583	DNA-binding transcription factor activity
CWC22_RS04550	COG1454	alcohol dehydrogenase
CWC22_RS04560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CWC22_RS04565	COG0583	DNA-binding transcription factor activity
CWC22_RS04575	COG0418	dihydroorotase activity
CWC22_RS04590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWC22_RS04620	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWC22_RS04625	COG0740	serine-type endopeptidase activity
CWC22_RS04630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWC22_RS04635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CWC22_RS04645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWC22_RS04670	COG3710	Transcriptional regulator
CWC22_RS04740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC22_RS04745	COG1136	(ABC) transporter
CWC22_RS04745	COG0577	efflux transmembrane transporter activity
CWC22_RS04755	COG4172	Belongs to the ABC transporter superfamily
CWC22_RS04775	COG0747	negative chemotaxis
CWC22_RS04780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWC22_RS04785	COG1842	Phage shock protein A
CWC22_RS04795	COG1983	PspC domain protein
CWC22_RS04800	COG3106	COG3106 Predicted ATPase
CWC22_RS04810	COG0626	cystathionine gamma-synthase activity
CWC22_RS04820	COG2154	pterin-4-alpha-carbinolamine dehydratase
CWC22_RS04825	COG2205	protein histidine kinase activity
CWC22_RS04825	COG3437	response regulator, receiver
CWC22_RS04825	COG4999	Histidine kinase
CWC22_RS04825	COG3850	Histidine kinase
CWC22_RS04830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWC22_RS04835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWC22_RS04840	COG3956	TIGRFAM MazG family protein
CWC22_RS04845	COG0504	CTP synthase activity
CWC22_RS04860	COG3066	DNA modification
CWC22_RS04865	COG1051	belongs to the nudix hydrolase family
CWC22_RS04870	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CWC22_RS04875	COG0730	response to heat
CWC22_RS04880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWC22_RS04885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWC22_RS04975	COG0784	Response regulator, receiver
CWC22_RS04975	COG0835	chemotaxis
CWC22_RS05015	COG0745	RESPONSE REGULATOR receiver
CWC22_RS05020	COG5002	protein histidine kinase activity
CWC22_RS05040	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CWC22_RS05045	COG1846	Transcriptional regulator
CWC22_RS05060	COG2313	pseudouridylate synthase activity
CWC22_RS05070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS05110	COG2204	response regulator
CWC22_RS05120	COG0577	efflux transmembrane transporter activity
CWC22_RS05120	COG1136	(ABC) transporter
CWC22_RS05145	COG1902	pentaerythritol trinitrate reductase activity
CWC22_RS05150	COG0697	spore germination
CWC22_RS05155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWC22_RS05160	COG0135	phosphoribosylanthranilate isomerase activity
CWC22_RS05190	COG0745	RESPONSE REGULATOR receiver
CWC22_RS05195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS05205	COG1858	cytochrome C peroxidase
CWC22_RS05225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWC22_RS05230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CWC22_RS05235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS05250	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWC22_RS05270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWC22_RS05285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWC22_RS05290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC22_RS05305	COG0745	RESPONSE REGULATOR receiver
CWC22_RS05315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWC22_RS05320	COG0789	Transcriptional regulator
CWC22_RS05345	COG0006	proline dipeptidase activity
CWC22_RS05350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC22_RS05355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWC22_RS05365	COG0583	DNA-binding transcription factor activity
CWC22_RS05375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWC22_RS05380	COG0509	glycine decarboxylation via glycine cleavage system
CWC22_RS05385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWC22_RS05385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWC22_RS05520	COG1228	amidohydrolase
CWC22_RS05575	COG5002	protein histidine kinase activity
CWC22_RS05580	COG0745	RESPONSE REGULATOR receiver
CWC22_RS05605	COG0488	(ABC) transporter
CWC22_RS05815	COG3437	response regulator, receiver
CWC22_RS05825	COG2205	protein histidine kinase activity
CWC22_RS05825	COG0784	Response regulator, receiver
CWC22_RS05830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CWC22_RS05835	COG0646	methionine synthase
CWC22_RS05835	COG1410	methionine synthase
CWC22_RS05840	COG1410	methionine synthase
CWC22_RS05840	COG0646	methionine synthase
CWC22_RS05850	COG4269	membrane
CWC22_RS05855	COG0501	Belongs to the peptidase M48B family
CWC22_RS05875	COG0784	Response regulator, receiver
CWC22_RS05875	COG2205	protein histidine kinase activity
CWC22_RS05875	COG5002	protein histidine kinase activity
CWC22_RS05880	COG0784	Response regulator, receiver
CWC22_RS05880	COG5002	protein histidine kinase activity
CWC22_RS05885	COG3706	GGDEF domain
CWC22_RS05885	COG4251	negative regulation of phosphorylation
CWC22_RS05885	COG5001	Diguanylate cyclase
CWC22_RS05885	COG2203	Gaf domain
CWC22_RS05895	COG1643	Atp-dependent helicase
CWC22_RS05925	COG0840	transmembrane signaling receptor activity
CWC22_RS05955	COG0840	transmembrane signaling receptor activity
CWC22_RS06045	COG1196	nuclear chromosome segregation
CWC22_RS06045	COG0739	heme binding
CWC22_RS06045	COG0741	lytic transglycosylase activity
CWC22_RS06060	COG3104	oligopeptide transport
CWC22_RS06120	COG3047	cAMP biosynthetic process
CWC22_RS06185	COG0779	Required for maturation of 30S ribosomal subunits
CWC22_RS06190	COG0195	Participates in both transcription termination and antitermination
CWC22_RS06195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWC22_RS06200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWC22_RS06205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWC22_RS06210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWC22_RS06215	COG1185	polyribonucleotide nucleotidyltransferase activity
CWC22_RS06230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWC22_RS06230	COG2111	Na H antiporter
CWC22_RS06235	COG1006	Multisubunit Na H antiporter MnhC subunit
CWC22_RS06240	COG0651	ATP synthesis coupled electron transport
CWC22_RS06245	COG1863	multisubunit Na H antiporter MnhE subunit
CWC22_RS06250	COG2212	antiporter activity
CWC22_RS06255	COG1320	monovalent cation:proton antiporter activity
CWC22_RS06260	COG0840	transmembrane signaling receptor activity
CWC22_RS06265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWC22_RS06290	COG1815	bacterial-type flagellum-dependent cell motility
CWC22_RS06295	COG1558	bacterial-type flagellum-dependent cell motility
CWC22_RS06310	COG4786	Flagellar basal body rod
CWC22_RS06315	COG4786	Flagellar basal body rod
CWC22_RS06320	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CWC22_RS06325	COG1706	bacterial-type flagellum-dependent cell motility
CWC22_RS06330	COG3951	Flagellar rod assembly protein muramidase FlgJ
CWC22_RS06330	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWC22_RS06335	COG1256	bacterial-type flagellum assembly
CWC22_RS06340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWC22_RS06345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWC22_RS06370	COG1516	flagellar protein fliS
CWC22_RS06385	COG4310	Domain of unknown function (DUF2172)
CWC22_RS06405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CWC22_RS06420	COG0673	inositol 2-dehydrogenase activity
CWC22_RS06430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWC22_RS06480	COG3958	Transketolase
CWC22_RS06485	COG3959	Transketolase, thiamine diphosphate binding domain
CWC22_RS06495	COG2226	methyltransferase
CWC22_RS06500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWC22_RS06505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CWC22_RS06515	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CWC22_RS06520	COG2089	acid synthase
CWC22_RS06535	COG0318	PFAM AMP-dependent synthetase and ligase
CWC22_RS06540	COG0673	inositol 2-dehydrogenase activity
CWC22_RS06545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWC22_RS06550	COG1086	Polysaccharide biosynthesis protein
CWC22_RS06555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWC22_RS06565	COG0519	Catalyzes the synthesis of GMP from XMP
CWC22_RS06580	COG1677	Flagellar hook-basal body complex protein FliE
CWC22_RS06590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWC22_RS06640	COG1987	bacterial-type flagellum assembly
CWC22_RS06645	COG1684	flagellar biosynthetic protein fliR
CWC22_RS06650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWC22_RS06655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWC22_RS06680	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CWC22_RS06685	COG0643	Histidine kinase
CWC22_RS06685	COG0784	Response regulator, receiver
CWC22_RS06685	COG2198	Histidine kinase
CWC22_RS06690	COG2201	protein-glutamate methylesterase activity
CWC22_RS06695	COG1192	Involved in chromosome partitioning
CWC22_RS06705	COG0835	chemotaxis
CWC22_RS06720	COG3292	Two component regulator propeller
CWC22_RS06720	COG2205	protein histidine kinase activity
CWC22_RS06720	COG0745	RESPONSE REGULATOR receiver
CWC22_RS06725	COG5002	protein histidine kinase activity
CWC22_RS06765	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWC22_RS06770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWC22_RS06775	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWC22_RS06780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CWC22_RS06785	COG1138	Cytochrome C-type biogenesis protein
CWC22_RS06795	COG4235	cytochrome complex assembly
CWC22_RS06795	COG3088	subunit of a heme lyase
CWC22_RS06805	COG2853	Lipoprotein
CWC22_RS06830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CWC22_RS06835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWC22_RS06855	COG0583	DNA-binding transcription factor activity
CWC22_RS06860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWC22_RS06880	COG2169	Transcriptional regulator
CWC22_RS06895	COG2171	N-acyltransferase activity
CWC22_RS06900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CWC22_RS06905	COG0024	Methionine aminopeptidase
CWC22_RS06910	COG0052	Belongs to the universal ribosomal protein uS2 family
CWC22_RS06915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWC22_RS06920	COG0528	UMP kinase activity
CWC22_RS06925	COG0233	cytoplasmic translational termination
CWC22_RS06930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWC22_RS06935	COG0575	Belongs to the CDS family
CWC22_RS06940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWC22_RS06945	COG0750	zinc metalloprotease
CWC22_RS06950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC22_RS06960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC22_RS06965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWC22_RS06970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC22_RS06975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC22_RS06980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWC22_RS06985	COG0587	DNA-directed DNA polymerase activity
CWC22_RS06990	COG0825	malonyl-CoA metabolic process
CWC22_RS07005	COG3706	GGDEF domain
CWC22_RS07040	COG4251	negative regulation of phosphorylation
CWC22_RS07045	COG0784	Response regulator, receiver
CWC22_RS07050	COG4251	negative regulation of phosphorylation
CWC22_RS07055	COG0784	Response regulator, receiver
CWC22_RS07060	COG1716	ATPase activity
CWC22_RS07060	COG5001	Diguanylate cyclase
CWC22_RS07100	COG3275	phosphorelay sensor kinase activity
CWC22_RS07105	COG0596	Alpha beta hydrolase
CWC22_RS07125	COG5507	3-demethylubiquinone-9 3-methyltransferase
CWC22_RS07155	COG1733	regulation of RNA biosynthetic process
CWC22_RS07160	COG3383	formate dehydrogenase (NAD+) activity
CWC22_RS07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWC22_RS07170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC22_RS07205	COG1131	(ABC) transporter
CWC22_RS07230	COG1278	Cold shock
CWC22_RS07245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWC22_RS07250	COG3002	Belongs to the UPF0753 family
CWC22_RS07390	COG2885	chlorophyll binding
CWC22_RS07395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC22_RS07395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CWC22_RS07400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWC22_RS07405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWC22_RS07410	COG2867	negative regulation of translational initiation
CWC22_RS07415	COG2914	Belongs to the UPF0125 (RnfH) family
CWC22_RS07430	COG1393	Belongs to the ArsC family
CWC22_RS07435	COG4783	chaperone-mediated protein folding
CWC22_RS07455	COG1104	cysteine desulfurase activity
CWC22_RS07460	COG1609	Transcriptional regulator
CWC22_RS07465	COG0166	Belongs to the GPI family
CWC22_RS07470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CWC22_RS07475	COG0363	glucosamine-6-phosphate deaminase activity
CWC22_RS07480	COG3385	transposase activity
CWC22_RS07485	COG0733	neurotransmitter:sodium symporter activity
CWC22_RS07490	COG2205	protein histidine kinase activity
CWC22_RS07495	COG0745	RESPONSE REGULATOR receiver
CWC22_RS07510	COG1534	Rna-binding protein
CWC22_RS07515	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CWC22_RS07520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWC22_RS07525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWC22_RS07530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWC22_RS07535	COG0149	triose-phosphate isomerase activity
CWC22_RS07540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWC22_RS07555	COG0210	DNA helicase
CWC22_RS07570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CWC22_RS07575	COG0602	queuosine metabolic process
CWC22_RS07610	COG2197	response regulator
CWC22_RS07615	COG0322	excinuclease ABC activity
CWC22_RS07685	COG1136	(ABC) transporter
CWC22_RS07695	COG1136	(ABC) transporter
CWC22_RS07725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWC22_RS07745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWC22_RS07760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWC22_RS07760	COG2207	Transcriptional regulator
CWC22_RS07765	COG3706	GGDEF domain
CWC22_RS07770	COG3385	transposase activity
CWC22_RS07775	COG0814	amino acid
CWC22_RS07785	COG0513	Belongs to the DEAD box helicase family
CWC22_RS07820	COG1671	Belongs to the UPF0178 family
CWC22_RS07895	COG2133	pyrroloquinoline quinone binding
CWC22_RS07915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC22_RS07920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC22_RS07925	COG3938	Belongs to the proline racemase family
CWC22_RS07935	COG1802	Transcriptional regulator
CWC22_RS07940	COG0457	Tetratricopeptide repeat
CWC22_RS07945	COG4771	TonB-dependent receptor
CWC22_RS08005	COG0121	glutamine amidotransferase
CWC22_RS08015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWC22_RS08020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWC22_RS08030	COG2854	intermembrane phospholipid transfer
CWC22_RS08045	COG2866	Carboxypeptidase
CWC22_RS08050	COG1115	amino acid carrier protein
CWC22_RS08060	COG3139	Protein of unknown function (DUF1315)
CWC22_RS08070	COG3385	transposase activity
CWC22_RS08075	COG1090	epimerase
CWC22_RS08080	COG0628	permease
CWC22_RS08105	COG2350	Protein conserved in bacteria
CWC22_RS08110	COG0733	neurotransmitter:sodium symporter activity
CWC22_RS08135	COG0134	indole-3-glycerol-phosphate synthase activity
CWC22_RS08135	COG0135	phosphoribosylanthranilate isomerase activity
CWC22_RS08140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWC22_RS08145	COG0512	Glutamine amidotransferase of anthranilate synthase
CWC22_RS08150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWC22_RS08155	COG0613	PHP domain protein
CWC22_RS08160	COG0009	L-threonylcarbamoyladenylate synthase
CWC22_RS08165	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWC22_RS08170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWC22_RS08175	COG1187	pseudouridine synthase activity
CWC22_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS08185	COG2267	carboxylic ester hydrolase activity
CWC22_RS08190	COG0616	signal peptide processing
CWC22_RS08210	COG3385	transposase activity
CWC22_RS08260	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CWC22_RS08260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWC22_RS08265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWC22_RS08280	COG0037	tRNA processing
CWC22_RS08285	COG0589	response to stress
CWC22_RS08290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWC22_RS08305	COG2217	Heavy metal translocating P-type atpase
CWC22_RS08315	COG2010	Cytochrome c
CWC22_RS08330	COG3278	Belongs to the heme-copper respiratory oxidase family
CWC22_RS08355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWC22_RS08385	COG0659	secondary active sulfate transmembrane transporter activity
CWC22_RS08390	COG4591	ABC-type transport system involved in lipoprotein release permease component
CWC22_RS08395	COG1136	(ABC) transporter
CWC22_RS08400	COG4591	ABC-type transport system involved in lipoprotein release permease component
CWC22_RS08405	COG2199	diguanylate cyclase activity
CWC22_RS08405	COG2200	EAL domain
CWC22_RS08405	COG2203	Gaf domain
CWC22_RS08410	COG2201	protein-glutamate methylesterase activity
CWC22_RS08430	COG0840	transmembrane signaling receptor activity
CWC22_RS08435	COG0643	Histidine kinase
CWC22_RS08435	COG2198	Histidine kinase
CWC22_RS08445	COG2201	protein-glutamate methylesterase activity
CWC22_RS08465	COG2850	peptidyl-arginine hydroxylation
CWC22_RS08470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWC22_RS08475	COG2915	High frequency lysogenization protein hflD homolog
CWC22_RS08480	COG0482	sulfurtransferase activity
CWC22_RS08485	COG1187	pseudouridine synthase activity
CWC22_RS08490	COG3385	transposase activity
CWC22_RS08500	COG1278	Cold shock
CWC22_RS08505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CWC22_RS08510	COG0542	response to heat
CWC22_RS08515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWC22_RS08520	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CWC22_RS08525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CWC22_RS08530	COG0492	ferredoxin-NADP+ reductase activity
CWC22_RS08535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWC22_RS08540	COG0367	asparagine synthase
CWC22_RS08545	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CWC22_RS08560	COG1984	allophanate hydrolase subunit 2
CWC22_RS08565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWC22_RS08570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWC22_RS08575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWC22_RS08575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWC22_RS08605	COG1609	Transcriptional regulator
CWC22_RS08620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWC22_RS08625	COG1288	antiporter activity
CWC22_RS08640	COG4771	TonB-dependent receptor
CWC22_RS08650	COG0563	adenylate kinase activity
CWC22_RS08655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC22_RS08660	COG2226	methyltransferase
CWC22_RS08670	COG4999	Histidine kinase
CWC22_RS08670	COG3850	Histidine kinase
CWC22_RS08670	COG3437	response regulator, receiver
CWC22_RS08670	COG2205	protein histidine kinase activity
CWC22_RS08685	COG2971	BadF BadG BcrA BcrD
CWC22_RS08690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWC22_RS08700	COG0363	glucosamine-6-phosphate deaminase activity
CWC22_RS08710	COG0626	cystathionine gamma-synthase activity
CWC22_RS08715	COG2925	Exonuclease
CWC22_RS08815	COG2988	succinylglutamate desuccinylase activity
CWC22_RS08825	COG0662	Cupin 2, conserved barrel domain protein
CWC22_RS08835	COG1115	amino acid carrier protein
CWC22_RS08880	COG4753	response regulator
CWC22_RS08880	COG2207	Transcriptional regulator
CWC22_RS08895	COG3604	Transcriptional regulator
CWC22_RS08925	COG4771	TonB-dependent receptor
CWC22_RS08930	COG0784	Response regulator, receiver
CWC22_RS08930	COG2205	protein histidine kinase activity
CWC22_RS08945	COG2920	part of a sulfur-relay system
CWC22_RS08955	COG2923	Belongs to the DsrF TusC family
CWC22_RS08965	COG0670	Belongs to the BI1 family
CWC22_RS08985	COG0583	DNA-binding transcription factor activity
CWC22_RS09005	COG1320	monovalent cation:proton antiporter activity
CWC22_RS09015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWC22_RS09015	COG2111	Na H antiporter
CWC22_RS09025	COG0651	ATP synthesis coupled electron transport
CWC22_RS09030	COG0651	ATP synthesis coupled electron transport
CWC22_RS09040	COG1956	GAF domain-containing protein
CWC22_RS09050	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CWC22_RS09060	COG1757	Na H antiporter
CWC22_RS09065	COG0308	aminopeptidase N
CWC22_RS09095	COG2902	Dehydrogenase
CWC22_RS09100	COG0167	dihydroorotate dehydrogenase activity
CWC22_RS09110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CWC22_RS09110	COG0116	Belongs to the methyltransferase superfamily
CWC22_RS09120	COG0488	(ABC) transporter
CWC22_RS09190	COG2205	protein histidine kinase activity
CWC22_RS09230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWC22_RS09235	COG0505	Belongs to the CarA family
CWC22_RS09240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWC22_RS09245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWC22_RS09300	COG3291	Pkd domain containing protein
CWC22_RS09310	COG0346	lactoylglutathione lyase activity
CWC22_RS09315	COG1404	Belongs to the peptidase S8 family
CWC22_RS09330	COG5001	Diguanylate cyclase
CWC22_RS09340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWC22_RS09345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWC22_RS09350	COG0072	phenylalanine-tRNA ligase activity
CWC22_RS09355	COG0776	regulation of translation
CWC22_RS09360	COG2200	EAL domain
CWC22_RS09365	COG0366	Alpha amylase catalytic
CWC22_RS09380	COG1523	belongs to the glycosyl hydrolase 13 family
CWC22_RS09395	COG3152	Membrane
CWC22_RS09420	COG1086	Polysaccharide biosynthesis protein
CWC22_RS09460	COG0415	Belongs to the DNA photolyase family
CWC22_RS09465	COG0415	Belongs to the DNA photolyase family
CWC22_RS09475	COG3046	protein related to deoxyribodipyrimidine photolyase
CWC22_RS09500	COG0583	DNA-binding transcription factor activity
CWC22_RS09510	COG3724	N-succinylarginine dihydrolase activity
CWC22_RS09550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS09555	COG4977	sequence-specific DNA binding
CWC22_RS09555	COG1917	Cupin 2, conserved barrel domain protein
CWC22_RS09565	COG2200	EAL domain
CWC22_RS09565	COG2199	diguanylate cyclase activity
CWC22_RS09565	COG2202	Pas domain
CWC22_RS09595	COG1785	Belongs to the alkaline phosphatase family
CWC22_RS09610	COG0735	belongs to the Fur family
CWC22_RS09630	COG0596	Alpha beta hydrolase
CWC22_RS09635	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CWC22_RS09640	COG0033	Phosphoglucomutase
CWC22_RS09645	COG2988	succinylglutamate desuccinylase activity
CWC22_RS09655	COG0022	dehydrogenase e1 component
CWC22_RS09670	COG1595	DNA-templated transcription, initiation
CWC22_RS09675	COG3806	Anti-sigma factor
CWC22_RS09685	COG4221	oxidoreductase activity
CWC22_RS09700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CWC22_RS09720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWC22_RS09735	COG1607	acyl-coa hydrolase
CWC22_RS09750	COG2056	Na+-H+ antiporter family
CWC22_RS09765	COG0714	Associated with various cellular activities
CWC22_RS09770	COG2201	protein-glutamate methylesterase activity
CWC22_RS09805	COG0281	malic enzyme
CWC22_RS09825	COG2855	membrane
CWC22_RS09830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CWC22_RS09835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWC22_RS09845	COG1309	transcriptional regulator
CWC22_RS09900	COG1054	Belongs to the UPF0176 family
CWC22_RS09905	COG0513	Belongs to the DEAD box helicase family
CWC22_RS09910	COG2996	Protein conserved in bacteria
CWC22_RS09940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CWC22_RS09940	COG0678	peroxiredoxin activity
CWC22_RS10000	COG0745	RESPONSE REGULATOR receiver
CWC22_RS10010	COG1720	tRNA m6t6A37 methyltransferase activity
CWC22_RS10015	COG0442	prolyl-tRNA aminoacylation
CWC22_RS10025	COG1668	transmembrane transport
CWC22_RS10030	COG4555	ABC transporter
CWC22_RS10050	COG3130	regulation of translation
CWC22_RS10055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWC22_RS10060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWC22_RS10065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWC22_RS10070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CWC22_RS10075	COG0531	amino acid
CWC22_RS10075	COG1674	ftsk spoiiie
CWC22_RS10085	COG0686	Belongs to the AlaDH PNT family
CWC22_RS10090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CWC22_RS10105	COG2957	Belongs to the agmatine deiminase family
CWC22_RS10110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWC22_RS10115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWC22_RS10140	COG3291	Pkd domain containing protein
CWC22_RS10175	COG0673	inositol 2-dehydrogenase activity
CWC22_RS10180	COG0662	Cupin 2, conserved barrel domain protein
CWC22_RS10180	COG2207	Transcriptional regulator
CWC22_RS10245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CWC22_RS10255	COG0156	8-amino-7-oxononanoate synthase activity
CWC22_RS10260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWC22_RS10265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWC22_RS10270	COG1509	lysine 2,3-aminomutase activity
CWC22_RS10280	COG0017	Asparaginyl-tRNA synthetase
CWC22_RS10300	COG1858	cytochrome C peroxidase
CWC22_RS10305	COG0840	transmembrane signaling receptor activity
CWC22_RS10315	COG0545	Peptidyl-prolyl cis-trans isomerase
CWC22_RS10345	COG0284	orotidine-5'-phosphate decarboxylase activity
CWC22_RS10350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CWC22_RS10360	COG0776	regulation of translation
CWC22_RS10365	COG0539	negative regulation of cytoplasmic translation
CWC22_RS10370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWC22_RS10375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWC22_RS10380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWC22_RS10390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC22_RS10400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWC22_RS10435	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWC22_RS10435	COG1902	pentaerythritol trinitrate reductase activity
CWC22_RS10440	COG0616	signal peptide processing
CWC22_RS10445	COG0252	asparaginase activity
CWC22_RS10450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWC22_RS10455	COG0469	pyruvate kinase activity
CWC22_RS10460	COG3279	Response regulator of the LytR AlgR family
CWC22_RS10465	COG3275	phosphorelay sensor kinase activity
CWC22_RS10490	COG3001	Fructosamine kinase
CWC22_RS10500	COG0307	riboflavin synthase, alpha
CWC22_RS10505	COG0534	Mate efflux family protein
CWC22_RS10575	COG3710	Transcriptional regulator
CWC22_RS10595	COG0659	secondary active sulfate transmembrane transporter activity
CWC22_RS10600	COG1522	sequence-specific DNA binding
CWC22_RS10605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWC22_RS10615	COG0300	oxidoreductase activity
CWC22_RS10620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWC22_RS10625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWC22_RS10630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWC22_RS10650	COG1132	(ABC) transporter
CWC22_RS10670	COG0318	PFAM AMP-dependent synthetase and ligase
CWC22_RS10675	COG0784	Response regulator, receiver
CWC22_RS10675	COG2205	protein histidine kinase activity
CWC22_RS10675	COG5002	protein histidine kinase activity
CWC22_RS10685	COG1397	ADP-ribosylglycohydrolase
CWC22_RS10745	COG1049	propionate catabolic process, 2-methylcitrate cycle
CWC22_RS10765	COG0189	ligase activity
CWC22_RS10770	COG0189	ligase activity
CWC22_RS10770	COG4067	protein conserved in archaea
CWC22_RS10775	COG4771	TonB-dependent receptor
CWC22_RS10840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CWC22_RS10845	COG1301	dicarboxylic acid transport
CWC22_RS10870	COG3179	chitinase
CWC22_RS10895	COG1301	dicarboxylic acid transport
CWC22_RS10965	COG3537	Alpha-1,2-mannosidase
CWC22_RS11035	COG0642	Histidine kinase
CWC22_RS11040	COG0745	RESPONSE REGULATOR receiver
CWC22_RS11245	COG1733	regulation of RNA biosynthetic process
CWC22_RS11250	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS11290	COG1309	transcriptional regulator
CWC22_RS11425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWC22_RS11445	COG0045	succinate-CoA ligase (ADP-forming) activity
CWC22_RS11450	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWC22_RS11455	COG0567	Dehydrogenase, E1 component
CWC22_RS11465	COG1053	succinate dehydrogenase
CWC22_RS11470	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CWC22_RS11490	COG2166	iron-sulfur cluster assembly
CWC22_RS11495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWC22_RS11500	COG0564	pseudouridine synthase activity
CWC22_RS11505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CWC22_RS11510	COG2835	tetraacyldisaccharide 4'-kinase activity
CWC22_RS11515	COG1663	tetraacyldisaccharide 4'-kinase activity
CWC22_RS11520	COG1132	(ABC) transporter
CWC22_RS11535	COG2095	MarC family integral membrane protein
CWC22_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS11555	COG1024	Enoyl-CoA hydratase
CWC22_RS11560	COG1024	Enoyl-CoA hydratase
CWC22_RS11575	COG0183	Belongs to the thiolase family
CWC22_RS11585	COG1960	acyl-CoA dehydrogenase activity
CWC22_RS11590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWC22_RS11610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CWC22_RS11615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CWC22_RS11620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWC22_RS11625	COG2176	DNA-directed DNA polymerase activity
CWC22_RS11635	COG0501	Belongs to the peptidase M48B family
CWC22_RS11650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CWC22_RS11660	COG2072	flavoprotein involved in K transport
CWC22_RS11675	COG1668	transmembrane transport
CWC22_RS11680	COG4555	ABC transporter
CWC22_RS11695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWC22_RS11705	COG1301	dicarboxylic acid transport
CWC22_RS11710	COG2084	Dehydrogenase
CWC22_RS11715	COG0386	Belongs to the glutathione peroxidase family
CWC22_RS11720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWC22_RS11740	COG0733	neurotransmitter:sodium symporter activity
CWC22_RS11750	COG0527	aspartate kinase activity
CWC22_RS11755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CWC22_RS11790	COG0708	Exodeoxyribonuclease III
CWC22_RS11800	COG2226	methyltransferase
CWC22_RS11805	COG3092	negative regulation of chromosome organization
CWC22_RS11810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWC22_RS11815	COG0857	belongs to the CobB CobQ family
CWC22_RS11815	COG0280	phosphate acetyltransferase
CWC22_RS11830	COG1393	Belongs to the ArsC family
CWC22_RS11835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC22_RS11840	COG1876	peptidase activity
CWC22_RS11845	COG0436	Aminotransferase
CWC22_RS11865	COG3706	GGDEF domain
CWC22_RS11865	COG4251	negative regulation of phosphorylation
CWC22_RS11865	COG2203	Gaf domain
CWC22_RS11865	COG5001	Diguanylate cyclase
CWC22_RS11870	COG0717	Belongs to the dCTP deaminase family
CWC22_RS11875	COG0489	protein tyrosine kinase activity
CWC22_RS11880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWC22_RS11880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWC22_RS11895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC22_RS11895	COG4191	Histidine kinase
CWC22_RS11905	COG0084	hydrolase, TatD family'
CWC22_RS11915	COG0470	DNA polymerase III
CWC22_RS11920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWC22_RS11940	COG0745	RESPONSE REGULATOR receiver
CWC22_RS11945	COG2205	protein histidine kinase activity
CWC22_RS11960	COG1643	Atp-dependent helicase
CWC22_RS11965	COG4109	DRTGG domain
CWC22_RS11990	COG0326	Molecular chaperone. Has ATPase activity
CWC22_RS11995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWC22_RS12005	COG2854	intermembrane phospholipid transfer
CWC22_RS12010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CWC22_RS12060	COG1215	transferase activity, transferring glycosyl groups
CWC22_RS12100	COG0737	Belongs to the 5'-nucleotidase family
CWC22_RS12115	COG4106	trans-aconitate 2-methyltransferase activity
CWC22_RS12130	COG1690	Belongs to the RtcB family
CWC22_RS12135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CWC22_RS12160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CWC22_RS12170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWC22_RS12180	COG3220	belongs to the UPF0276 family
CWC22_RS12190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWC22_RS12215	COG0848	biopolymer transport protein
CWC22_RS12220	COG0811	peptide transport
CWC22_RS12225	COG0811	peptide transport
CWC22_RS12250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWC22_RS12255	COG0494	nUDIX hydrolase
CWC22_RS12260	COG1760	l-serine dehydratase
CWC22_RS12275	COG2252	PERMEase
CWC22_RS12305	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWC22_RS12305	COG1024	Enoyl-CoA hydratase
CWC22_RS12330	COG1418	mRNA catabolic process
CWC22_RS12335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CWC22_RS12340	COG1404	Belongs to the peptidase S8 family
CWC22_RS12375	COG2267	carboxylic ester hydrolase activity
CWC22_RS12380	COG1619	proteins homologs of microcin C7 resistance protein MccF
CWC22_RS12400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWC22_RS12405	COG1228	amidohydrolase
CWC22_RS12445	COG2329	Antibiotic biosynthesis monooxygenase
CWC22_RS12510	COG1136	(ABC) transporter
CWC22_RS12510	COG0577	efflux transmembrane transporter activity
CWC22_RS12515	COG0577	efflux transmembrane transporter activity
CWC22_RS12525	COG5002	protein histidine kinase activity
CWC22_RS12530	COG3040	lipid binding
CWC22_RS12535	COG2824	Alkylphosphonate utilization operon protein PhnA
CWC22_RS12560	COG3850	Histidine kinase
CWC22_RS12560	COG5002	protein histidine kinase activity
CWC22_RS12590	COG1309	transcriptional regulator
CWC22_RS12600	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWC22_RS12615	COG0534	Mate efflux family protein
CWC22_RS12650	COG1280	lysine exporter protein (LysE YggA)
CWC22_RS12675	COG4251	negative regulation of phosphorylation
CWC22_RS12675	COG2203	Gaf domain
CWC22_RS12675	COG3706	GGDEF domain
CWC22_RS12675	COG5001	Diguanylate cyclase
CWC22_RS12685	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWC22_RS12710	COG3101	peptidyl-lysine hydroxylation
CWC22_RS12715	COG3706	GGDEF domain
CWC22_RS12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWC22_RS12720	COG1024	Enoyl-CoA hydratase
CWC22_RS12725	COG0183	Belongs to the thiolase family
CWC22_RS12730	COG0714	Associated with various cellular activities
CWC22_RS12750	COG2304	oxidoreductase activity
CWC22_RS12760	COG1595	DNA-templated transcription, initiation
CWC22_RS12820	COG2423	ornithine cyclodeaminase activity
CWC22_RS12825	COG0006	proline dipeptidase activity
CWC22_RS12845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWC22_RS12850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWC22_RS12855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWC22_RS12860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWC22_RS12870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWC22_RS12875	COG0416	fatty acid biosynthetic process
CWC22_RS12880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWC22_RS12885	COG1399	metal-binding, possibly nucleic acid-binding protein
CWC22_RS12890	COG0424	maF-like protein
CWC22_RS12895	COG0546	phosphoglycolate phosphatase activity
CWC22_RS12900	COG0564	pseudouridine synthase activity
CWC22_RS12905	COG1530	ribonuclease E activity
CWC22_RS12935	COG3081	Nucleoid-associated protein
CWC22_RS12940	COG3082	Protein of unknown function (DUF1414)
CWC22_RS12955	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CWC22_RS13000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWC22_RS13005	COG1074	ATP-dependent DNA helicase activity
CWC22_RS13010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CWC22_RS13025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CWC22_RS13070	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CWC22_RS13075	COG2885	chlorophyll binding
CWC22_RS13080	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS13090	COG0848	biopolymer transport protein
CWC22_RS13095	COG0811	peptide transport
CWC22_RS13100	COG2255	four-way junction helicase activity
CWC22_RS13105	COG0632	four-way junction helicase activity
CWC22_RS13110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CWC22_RS13115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWC22_RS13120	COG1801	Protein of unknown function DUF72
CWC22_RS13130	COG1451	nucleotide metabolic process
CWC22_RS13140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWC22_RS13145	COG1420	regulation of RNA biosynthetic process
CWC22_RS13150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWC22_RS13160	COG0497	DNA recombination
CWC22_RS13165	COG0493	'glutamate synthase
CWC22_RS13170	COG0067	glutamate synthase
CWC22_RS13170	COG0069	glutamate synthase activity
CWC22_RS13170	COG0070	glutamate synthase
CWC22_RS13175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CWC22_RS13180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWC22_RS13185	COG2766	serine protein kinase
CWC22_RS13190	COG2718	Belongs to the UPF0229 family
CWC22_RS13195	COG2719	SpoVR family
CWC22_RS13200	COG3706	GGDEF domain
CWC22_RS13205	COG2201	protein-glutamate methylesterase activity
CWC22_RS13210	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWC22_RS13220	COG4326	sporulation control protein
CWC22_RS13260	COG0583	DNA-binding transcription factor activity
CWC22_RS13265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWC22_RS13270	COG0840	transmembrane signaling receptor activity
CWC22_RS13280	COG2234	aminopeptidase activity
CWC22_RS13285	COG2827	Endonuclease containing a URI domain
CWC22_RS13290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC22_RS13305	COG3314	Sporulation integral membrane protein YlbJ
CWC22_RS13315	COG2716	regulation of RNA biosynthetic process
CWC22_RS13320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWC22_RS13325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CWC22_RS13330	COG1381	Involved in DNA repair and RecF pathway recombination
CWC22_RS13340	COG0571	ribonuclease III activity
CWC22_RS13345	COG0681	Belongs to the peptidase S26 family
CWC22_RS13350	COG0481	GTPase activity
CWC22_RS13360	COG3026	antisigma factor binding
CWC22_RS13365	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CWC22_RS13370	COG1595	DNA-templated transcription, initiation
CWC22_RS13375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CWC22_RS13385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CWC22_RS13390	COG0354	folic acid binding
CWC22_RS13395	COG1047	Peptidyl-prolyl cis-trans
CWC22_RS13410	COG3099	Belongs to the UPF0263 family
CWC22_RS13415	COG1024	Enoyl-CoA hydratase
CWC22_RS13420	COG1380	Effector of murein hydrolase LrgA
CWC22_RS13425	COG1346	cytolysis
CWC22_RS13430	COG0668	transmembrane transport
CWC22_RS13435	COG3469	chitinase activity
CWC22_RS13435	COG3325	Belongs to the glycosyl hydrolase 18 family
CWC22_RS13445	COG0625	glutathione transferase activity
CWC22_RS13460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWC22_RS13465	COG2890	protein-(glutamine-N5) methyltransferase activity
CWC22_RS13470	COG2840	Smr protein MutS2
CWC22_RS13475	COG0745	RESPONSE REGULATOR receiver
CWC22_RS13485	COG0450	alkyl hydroperoxide reductase
CWC22_RS13505	COG2311	Membrane
CWC22_RS13520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CWC22_RS13535	COG4771	TonB-dependent receptor
CWC22_RS13545	COG2183	response to ionizing radiation
CWC22_RS13550	COG3141	response to X-ray
CWC22_RS13555	COG1448	Aminotransferase
CWC22_RS13575	COG0023	Translation Initiation Factor
CWC22_RS13585	COG0077	Prephenate dehydratase
CWC22_RS13585	COG1605	Chorismate mutase
CWC22_RS13590	COG0287	Prephenate dehydrogenase
CWC22_RS13590	COG1605	Chorismate mutase
CWC22_RS13595	COG0335	large ribosomal subunit rRNA binding
CWC22_RS13600	COG0336	Belongs to the RNA methyltransferase TrmD family
CWC22_RS13605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWC22_RS13610	COG0228	four-way junction DNA binding
CWC22_RS13615	COG4771	TonB-dependent receptor
CWC22_RS13620	COG4558	Periplasmic binding protein
CWC22_RS13625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWC22_RS13630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CWC22_RS13640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWC22_RS13645	COG4137	Cytochrome C assembly protein
CWC22_RS13650	COG4536	flavin adenine dinucleotide binding
CWC22_RS13660	COG2918	glutathione biosynthetic process
CWC22_RS13670	COG0542	response to heat
CWC22_RS13675	COG1496	oxidoreductase activity
CWC22_RS13680	COG0564	pseudouridine synthase activity
CWC22_RS13685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC22_RS13735	COG2972	Histidine kinase
CWC22_RS13740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWC22_RS13745	COG1047	Peptidyl-prolyl cis-trans
CWC22_RS13750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWC22_RS13755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CWC22_RS13760	COG0196	riboflavin kinase activity
CWC22_RS13765	COG0728	peptidoglycan biosynthetic process
CWC22_RS13770	COG0268	Binds directly to 16S ribosomal RNA
CWC22_RS13775	COG2201	protein-glutamate methylesterase activity
CWC22_RS13800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC22_RS13820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWC22_RS13835	COG3228	Belongs to the MtfA family
CWC22_RS13840	COG1643	Atp-dependent helicase
CWC22_RS13855	COG4206	TonB-dependent receptor
CWC22_RS13865	COG0417	DNA replication proofreading
CWC22_RS13870	COG1199	ATP-dependent helicase activity
CWC22_RS13875	COG0730	response to heat
CWC22_RS13885	COG0123	including yeast histone deacetylase and acetoin utilization protein
CWC22_RS13930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CWC22_RS13935	COG3961	Belongs to the TPP enzyme family
CWC22_RS13955	COG0534	Mate efflux family protein
CWC22_RS13970	COG0745	RESPONSE REGULATOR receiver
CWC22_RS13980	COG1960	acyl-CoA dehydrogenase activity
CWC22_RS13985	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CWC22_RS13990	COG3848	Pyruvate phosphate dikinase
CWC22_RS13990	COG0574	Belongs to the PEP-utilizing enzyme family
CWC22_RS13995	COG0028	Belongs to the TPP enzyme family
CWC22_RS14005	COG1414	Transcriptional regulator
CWC22_RS14005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWC22_RS14010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWC22_RS14015	COG0156	8-amino-7-oxononanoate synthase activity
CWC22_RS14020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS14025	COG3321	synthase
CWC22_RS14040	COG0778	Nitroreductase
CWC22_RS14055	COG1280	lysine exporter protein (LysE YggA)
CWC22_RS14060	COG1803	Methylglyoxal synthase
CWC22_RS14065	COG0443	Heat shock 70 kDa protein
CWC22_RS14070	COG1793	dna ligase
CWC22_RS14085	COG4771	TonB-dependent receptor
CWC22_RS14095	COG1025	Belongs to the peptidase M16 family
CWC22_RS14100	COG3300	MHYT domain
CWC22_RS14100	COG5001	Diguanylate cyclase
CWC22_RS14110	COG2315	Protein conserved in bacteria
CWC22_RS14120	COG0205	6-phosphofructokinase activity
CWC22_RS14140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CWC22_RS14145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CWC22_RS14150	COG3178	'Phosphotransferase
CWC22_RS14155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CWC22_RS14160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWC22_RS14165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CWC22_RS14170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWC22_RS14175	COG2967	ApaG domain
CWC22_RS14180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWC22_RS14185	COG0840	transmembrane signaling receptor activity
CWC22_RS14200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CWC22_RS14205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWC22_RS14220	COG3025	triphosphatase activity
CWC22_RS14225	COG4991	sh3 domain protein
CWC22_RS14230	COG0545	Peptidyl-prolyl cis-trans isomerase
CWC22_RS14235	COG1067	ATP-dependent peptidase activity
CWC22_RS14240	COG2888	peptidyl-tyrosine sulfation
CWC22_RS14245	COG0495	leucyl-tRNA aminoacylation
CWC22_RS14250	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CWC22_RS14260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWC22_RS14265	COG0799	negative regulation of ribosome biogenesis
CWC22_RS14270	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWC22_RS14275	COG0768	penicillin binding
CWC22_RS14280	COG0772	Belongs to the SEDS family
CWC22_RS14285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CWC22_RS14290	COG1686	Belongs to the peptidase S11 family
CWC22_RS14295	COG2921	Belongs to the UPF0250 family
CWC22_RS14300	COG0321	lipoyl(octanoyl) transferase activity
CWC22_RS14305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWC22_RS14325	COG0644	oxidoreductase
CWC22_RS14345	COG1404	Belongs to the peptidase S8 family
CWC22_RS14375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWC22_RS14380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC22_RS14400	COG1902	pentaerythritol trinitrate reductase activity
CWC22_RS14405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWC22_RS14420	COG3243	poly(R)-hydroxyalkanoic acid synthase
CWC22_RS14430	COG1166	arginine decarboxylase activity
CWC22_RS14435	COG0010	Belongs to the arginase family
CWC22_RS14455	COG0215	cysteine-tRNA ligase activity
CWC22_RS14460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWC22_RS14465	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CWC22_RS14480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CWC22_RS14485	COG1286	toxin biosynthetic process
CWC22_RS14495	COG0285	dihydrofolate synthase activity
CWC22_RS14500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWC22_RS14505	COG0101	tRNA pseudouridine synthase activity
CWC22_RS14520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWC22_RS14530	COG1960	acyl-CoA dehydrogenase activity
CWC22_RS14540	COG1116	anion transmembrane transporter activity
CWC22_RS14615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWC22_RS14620	COG0328	RNA-DNA hybrid ribonuclease activity
CWC22_RS14625	COG2226	methyltransferase
CWC22_RS14630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWC22_RS14635	COG0741	lytic transglycosylase activity
CWC22_RS14635	COG1388	LysM domain
CWC22_RS14645	COG0564	pseudouridine synthase activity
CWC22_RS14680	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CWC22_RS14690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWC22_RS14690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWC22_RS14710	COG0729	surface antigen
CWC22_RS14720	COG1061	Type III restriction enzyme res subunit
CWC22_RS14730	COG3706	GGDEF domain
CWC22_RS14735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CWC22_RS14745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWC22_RS14750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWC22_RS14765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWC22_RS14765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWC22_RS14770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWC22_RS14775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWC22_RS14790	COG0527	aspartate kinase activity
CWC22_RS14790	COG0460	homoserine dehydrogenase
CWC22_RS14795	COG0745	RESPONSE REGULATOR receiver
CWC22_RS14800	COG4191	Histidine kinase
CWC22_RS14805	COG2974	May be involved in recombination
CWC22_RS14830	COG0840	transmembrane signaling receptor activity
CWC22_RS14835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWC22_RS14840	COG1966	Carbon starvation protein
CWC22_RS14845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWC22_RS14875	COG0667	Aldo Keto reductase
CWC22_RS14890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWC22_RS14890	COG1042	CoA-binding domain protein
CWC22_RS14890	COG0045	succinate-CoA ligase (ADP-forming) activity
CWC22_RS14895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWC22_RS14920	COG3313	Fe-S protein
CWC22_RS14985	COG0511	ligase activity, forming carbon-carbon bonds
CWC22_RS14985	COG5016	pyruvate
CWC22_RS14990	COG3630	sodium ion export across plasma membrane
CWC22_RS15000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CWC22_RS15010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWC22_RS15015	COG2137	regulation of response to DNA damage stimulus
CWC22_RS15025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWC22_RS15065	COG1757	Na H antiporter
CWC22_RS15070	COG1737	Transcriptional regulator
CWC22_RS15075	COG3876	Protein conserved in bacteria
CWC22_RS15105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWC22_RS15120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWC22_RS15130	COG0716	FMN binding
CWC22_RS15140	COG2207	Transcriptional regulator
CWC22_RS15185	COG2373	Large extracellular alpha-helical protein
CWC22_RS15190	COG4953	penicillin-binding protein 1C
CWC22_RS15200	COG0577	efflux transmembrane transporter activity
CWC22_RS15205	COG0577	efflux transmembrane transporter activity
CWC22_RS15205	COG1136	(ABC) transporter
CWC22_RS15210	COG1136	(ABC) transporter
CWC22_RS15210	COG0577	efflux transmembrane transporter activity
CWC22_RS15215	COG1136	(ABC) transporter
CWC22_RS15215	COG0577	efflux transmembrane transporter activity
CWC22_RS15220	COG1136	(ABC) transporter
CWC22_RS15265	COG0488	(ABC) transporter
CWC22_RS15270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CWC22_RS15295	COG3710	Transcriptional regulator
CWC22_RS15300	COG2315	Protein conserved in bacteria
CWC22_RS15320	COG1280	lysine exporter protein (LysE YggA)
CWC22_RS15325	COG4774	siderophore transport
CWC22_RS15325	COG1629	transport
CWC22_RS15365	COG1115	amino acid carrier protein
CWC22_RS15375	COG0443	Heat shock 70 kDa protein
CWC22_RS15380	COG2214	Heat shock protein DnaJ domain protein
CWC22_RS15395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWC22_RS15400	COG2205	protein histidine kinase activity
CWC22_RS15425	COG3036	rescue of stalled ribosome
CWC22_RS15430	COG0596	Alpha beta hydrolase
CWC22_RS15440	COG0390	transport system, permease component
CWC22_RS15465	COG1683	Conserved Protein
CWC22_RS15495	COG0513	Belongs to the DEAD box helicase family
CWC22_RS15500	COG0513	Belongs to the DEAD box helicase family
CWC22_RS15510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWC22_RS15515	COG0848	biopolymer transport protein
CWC22_RS15545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CWC22_RS15560	COG0668	transmembrane transport
CWC22_RS15610	COG3655	Transcriptional regulator
CWC22_RS15620	COG0745	RESPONSE REGULATOR receiver
CWC22_RS15625	COG2205	protein histidine kinase activity
CWC22_RS15630	COG4452	Inner membrane protein CreD
CWC22_RS15650	COG1733	regulation of RNA biosynthetic process
CWC22_RS15655	COG1942	4-Oxalocrotonate Tautomerase
CWC22_RS15670	COG0583	DNA-binding transcription factor activity
CWC22_RS15685	COG0564	pseudouridine synthase activity
CWC22_RS15690	COG1473	amidohydrolase
CWC22_RS15695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWC22_RS15705	COG3409	Peptidoglycan-binding domain 1 protein
CWC22_RS15705	COG3267	Type II secretory pathway component ExeA
CWC22_RS15710	COG0617	tRNA 3'-terminal CCA addition
CWC22_RS15730	COG1216	Glycosyl transferase, family 2
CWC22_RS15740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWC22_RS15745	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CWC22_RS15765	COG2204	response regulator
CWC22_RS15775	COG1216	Glycosyl transferase, family 2
CWC22_RS15815	COG1473	amidohydrolase
CWC22_RS15825	COG2801	Transposase and inactivated derivatives
CWC22_RS15830	COG0577	efflux transmembrane transporter activity
CWC22_RS15830	COG1136	(ABC) transporter
CWC22_RS15835	COG0577	efflux transmembrane transporter activity
CWC22_RS15835	COG1136	(ABC) transporter
CWC22_RS15840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC22_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS15875	COG3321	synthase
CWC22_RS15875	COG0604	alcohol dehydrogenase
CWC22_RS15885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWC22_RS15890	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWC22_RS15895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CWC22_RS15940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWC22_RS15940	COG2070	2-Nitropropane dioxygenase
CWC22_RS15950	COG2192	nodulation
CWC22_RS15955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS15955	COG0318	PFAM AMP-dependent synthetase and ligase
CWC22_RS15955	COG0300	oxidoreductase activity
CWC22_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS15955	COG3321	synthase
CWC22_RS15960	COG0560	Phosphoserine phosphatase
CWC22_RS15980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS15995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWC22_RS16000	COG0318	PFAM AMP-dependent synthetase and ligase
CWC22_RS16010	COG0084	hydrolase, TatD family'
CWC22_RS16015	COG0259	pyridoxamine-phosphate oxidase activity
CWC22_RS16020	COG0018	arginyl-trna synthetase
CWC22_RS16035	COG0598	Magnesium transport protein CorA
CWC22_RS16085	COG1012	belongs to the aldehyde dehydrogenase family
CWC22_RS16095	COG0443	Heat shock 70 kDa protein
CWC22_RS16100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CWC22_RS16110	COG0822	iron-sulfur transferase activity
CWC22_RS16115	COG1104	cysteine desulfurase activity
CWC22_RS16125	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CWC22_RS16130	COG0483	inositol monophosphate 1-phosphatase activity
CWC22_RS16135	COG4948	Mandelate Racemase Muconate Lactonizing
CWC22_RS16150	COG3122	Protein conserved in bacteria
CWC22_RS16175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWC22_RS16180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWC22_RS16190	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CWC22_RS16195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWC22_RS16200	COG0330	HflC and HflK could
CWC22_RS16205	COG0330	HflC and HflK could
CWC22_RS16210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWC22_RS16215	COG1923	regulation of RNA biosynthetic process
CWC22_RS16220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWC22_RS16225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWC22_RS16235	COG0802	atpase or kinase
CWC22_RS16240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CWC22_RS16240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWC22_RS16245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWC22_RS16285	COG1160	GTP binding
CWC22_RS16290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWC22_RS16295	COG2976	Protein conserved in bacteria
CWC22_RS16300	COG0124	histidyl-tRNA synthetase
CWC22_RS16305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWC22_RS16320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWC22_RS16325	COG0105	UTP biosynthetic process
CWC22_RS16330	COG0826	peptidase U32
CWC22_RS16335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWC22_RS16340	COG2200	EAL domain
CWC22_RS16345	COG2205	protein histidine kinase activity
CWC22_RS16390	COG0346	lactoylglutathione lyase activity
CWC22_RS16400	COG0577	efflux transmembrane transporter activity
CWC22_RS16400	COG1136	(ABC) transporter
CWC22_RS16410	COG0745	RESPONSE REGULATOR receiver
CWC22_RS16415	COG5002	protein histidine kinase activity
CWC22_RS16430	COG0745	RESPONSE REGULATOR receiver
CWC22_RS16450	COG4774	siderophore transport
CWC22_RS16460	COG4191	Histidine kinase
CWC22_RS16475	COG1136	(ABC) transporter
CWC22_RS16475	COG0577	efflux transmembrane transporter activity
CWC22_RS16480	COG0577	efflux transmembrane transporter activity
CWC22_RS16485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWC22_RS16495	COG3710	Transcriptional regulator
CWC22_RS16500	COG4771	TonB-dependent receptor
CWC22_RS16505	COG0789	Transcriptional regulator
CWC22_RS16520	COG2081	HI0933 family
CWC22_RS16525	COG1404	Belongs to the peptidase S8 family
CWC22_RS16540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CWC22_RS16545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CWC22_RS16550	COG0585	pseudouridine synthase activity
CWC22_RS16555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWC22_RS16560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWC22_RS16565	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CWC22_RS16585	COG3604	Transcriptional regulator
CWC22_RS16615	COG0583	DNA-binding transcription factor activity
CWC22_RS16620	COG3085	chromosome segregation
CWC22_RS16625	COG2962	Rard protein
CWC22_RS16630	COG0514	ATP-dependent DNA helicase (RecQ)
CWC22_RS16660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWC22_RS16665	COG0784	Response regulator, receiver
CWC22_RS16665	COG2205	protein histidine kinase activity
CWC22_RS16670	COG0456	acetyltransferase
CWC22_RS16685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWC22_RS16685	COG0519	Catalyzes the synthesis of GMP from XMP
CWC22_RS16690	COG0517	IMP dehydrogenase activity
CWC22_RS16690	COG0516	GMP reductase activity
CWC22_RS16695	COG1570	exodeoxyribonuclease VII activity
CWC22_RS16705	COG1045	serine acetyltransferase
CWC22_RS16710	COG0612	Peptidase, M16
CWC22_RS16720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWC22_RS16725	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CWC22_RS16730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CWC22_RS16740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CWC22_RS16745	COG4942	peptidase
CWC22_RS16750	COG0793	Belongs to the peptidase S41A family
CWC22_RS16765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWC22_RS16770	COG1489	DNA binding
CWC22_RS16780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWC22_RS16790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWC22_RS16795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWC22_RS16800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWC22_RS16815	COG5002	protein histidine kinase activity
CWC22_RS16820	COG0745	RESPONSE REGULATOR receiver
CWC22_RS16835	COG0126	phosphoglycerate kinase activity
CWC22_RS16840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWC22_RS16845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWC22_RS16850	COG0517	IMP dehydrogenase activity
CWC22_RS16850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CWC22_RS16855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWC22_RS16865	COG0784	Response regulator, receiver
CWC22_RS16865	COG2205	protein histidine kinase activity
CWC22_RS16875	COG0076	glutamate decarboxylase activity
CWC22_RS16885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWC22_RS16890	COG0842	Transport permease protein
CWC22_RS16895	COG1131	(ABC) transporter
CWC22_RS16900	COG0163	prenyltransferase activity
CWC22_RS16905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWC22_RS16910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWC22_RS16915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CWC22_RS16920	COG1561	YicC-like family, N-terminal region
CWC22_RS16945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWC22_RS16980	COG3727	T/G mismatch-specific endonuclease activity
CWC22_RS16995	COG1396	sequence-specific DNA binding
CWC22_RS17000	COG4106	trans-aconitate 2-methyltransferase activity
CWC22_RS17005	COG0194	GDP metabolic process
CWC22_RS17010	COG1758	RNA polymerase activity
CWC22_RS17015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWC22_RS17035	COG1522	sequence-specific DNA binding
CWC22_RS17040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWC22_RS17045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWC22_RS17050	COG0346	lactoylglutathione lyase activity
CWC22_RS17065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWC22_RS17080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWC22_RS17085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWC22_RS17090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWC22_RS17095	COG0142	geranyltranstransferase activity
CWC22_RS17100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CWC22_RS17105	COG1194	a g-specific adenine glycosylase
CWC22_RS17110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWC22_RS17115	COG2813	Specifically methylates the guanine in position
CWC22_RS17120	COG4191	Histidine kinase
CWC22_RS17120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC22_RS17130	COG0745	RESPONSE REGULATOR receiver
CWC22_RS17135	COG2198	Histidine kinase
CWC22_RS17135	COG0784	Response regulator, receiver
CWC22_RS17135	COG5002	protein histidine kinase activity
CWC22_RS17140	COG1469	GTP cyclohydrolase I activity
CWC22_RS17150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWC22_RS17160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CWC22_RS17165	COG0739	heme binding
CWC22_RS17175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CWC22_RS17185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CWC22_RS17190	COG3023	N-Acetylmuramoyl-L-alanine amidase
CWC22_RS17210	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CWC22_RS17215	COG0237	dephospho-CoA kinase activity
CWC22_RS17225	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CWC22_RS17235	COG0745	RESPONSE REGULATOR receiver
CWC22_RS17240	COG2205	protein histidine kinase activity
CWC22_RS17255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CWC22_RS17295	COG0367	asparagine synthase
CWC22_RS17300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWC22_RS17315	COG0367	asparagine synthase
CWC22_RS17330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWC22_RS17335	COG1596	polysaccharide export
CWC22_RS17340	COG1083	cytidylyl-transferase
CWC22_RS17355	COG2089	acid synthase
CWC22_RS17360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWC22_RS17365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWC22_RS17395	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWC22_RS17400	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CWC22_RS17405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWC22_RS17420	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CWC22_RS17425	COG1088	dTDP-glucose 4,6-dehydratase activity
CWC22_RS17435	COG0438	transferase activity, transferring glycosyl groups
CWC22_RS17445	COG1215	transferase activity, transferring glycosyl groups
CWC22_RS17450	COG1215	transferase activity, transferring glycosyl groups
CWC22_RS17455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWC22_RS17475	COG0668	transmembrane transport
CWC22_RS17495	COG3590	peptidase
CWC22_RS17505	COG0653	protein targeting
CWC22_RS17515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CWC22_RS17520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWC22_RS17525	COG0849	cell division
CWC22_RS17530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CWC22_RS17535	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWC22_RS17540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWC22_RS17545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWC22_RS17550	COG0772	Belongs to the SEDS family
CWC22_RS17555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWC22_RS17560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWC22_RS17565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWC22_RS17570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWC22_RS17575	COG0768	penicillin binding
CWC22_RS17580	COG3116	cell division
CWC22_RS17585	COG0275	rRNA processing
CWC22_RS17590	COG2001	Belongs to the MraZ family
CWC22_RS17610	COG1785	Belongs to the alkaline phosphatase family
CWC22_RS17615	COG3263	regulation of cellular component size
CWC22_RS17625	COG1227	inorganic diphosphatase activity
CWC22_RS17630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWC22_RS17635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWC22_RS17640	COG2003	Belongs to the UPF0758 family
CWC22_RS17645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWC22_RS17655	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS17655	COG4946	Tricorn protease homolog
CWC22_RS17655	COG1506	peptidase
CWC22_RS17660	COG1032	radical SAM domain protein
CWC22_RS17705	COG1842	Phage shock protein A
CWC22_RS17710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWC22_RS17715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWC22_RS17725	COG3954	Phosphoribulokinase
CWC22_RS17730	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CWC22_RS17735	COG1011	Hydrolase
CWC22_RS17740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWC22_RS17745	COG0557	exoribonuclease II activity
CWC22_RS17755	COG0697	spore germination
CWC22_RS17760	COG0584	glycerophosphoryl diester phosphodiesterase
CWC22_RS17770	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CWC22_RS17775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWC22_RS17800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS17815	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CWC22_RS17830	COG1842	Phage shock protein A
CWC22_RS17840	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWC22_RS17860	COG4326	sporulation control protein
CWC22_RS17870	COG0459	protein refolding
CWC22_RS17875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWC22_RS17885	COG1324	tolerance protein
CWC22_RS17890	COG4232	protein-disulfide reductase activity
CWC22_RS17895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CWC22_RS17900	COG0511	ligase activity, forming carbon-carbon bonds
CWC22_RS17905	COG0439	Biotin carboxylase
CWC22_RS17920	COG3078	GTPase activator activity
CWC22_RS17925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC22_RS17935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWC22_RS17950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWC22_RS17950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWC22_RS17955	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CWC22_RS17980	COG0288	reversible hydration of carbon dioxide
CWC22_RS17990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWC22_RS18000	COG0129	dihydroxy-acid dehydratase activity
CWC22_RS18005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWC22_RS18030	COG2205	protein histidine kinase activity
CWC22_RS18030	COG0784	Response regulator, receiver
CWC22_RS18035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC22_RS18045	COG0019	diaminopimelate decarboxylase activity
CWC22_RS18060	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CWC22_RS18065	COG0456	acetyltransferase
CWC22_RS18075	COG1490	D-aminoacyl-tRNA deacylase activity
CWC22_RS18085	COG1295	ribonuclease BN
CWC22_RS18105	COG2501	S4 domain
CWC22_RS18110	COG2050	protein possibly involved in aromatic compounds catabolism
CWC22_RS18140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWC22_RS18145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CWC22_RS18150	COG2356	endonuclease I
CWC22_RS18230	COG0546	phosphoglycolate phosphatase activity
CWC22_RS18250	COG1566	PFAM secretion protein HlyD family protein
CWC22_RS18290	COG1021	2,3-dihydroxybenzoate-AMP ligase
CWC22_RS18295	COG1535	isochorismatase
CWC22_RS18295	COG3433	isochorismatase activity
CWC22_RS18300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS18305	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS18310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWC22_RS18325	COG4774	siderophore transport
CWC22_RS18360	COG1595	DNA-templated transcription, initiation
CWC22_RS18380	COG0066	3-isopropylmalate dehydratase activity
CWC22_RS18385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWC22_RS18390	COG0473	3-isopropylmalate dehydrogenase activity
CWC22_RS18395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWC22_RS18420	COG0203	ribosomal protein L17
CWC22_RS18425	COG0202	RNA polymerase activity
CWC22_RS18430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWC22_RS18435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CWC22_RS18440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWC22_RS18445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWC22_RS18450	COG0201	protein transport
CWC22_RS18455	COG0200	Binds to the 23S rRNA
CWC22_RS18460	COG1841	ribosomal large subunit assembly
CWC22_RS18465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWC22_RS18470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWC22_RS18475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWC22_RS18480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWC22_RS18485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWC22_RS18490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWC22_RS18495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWC22_RS18500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWC22_RS18525	COG4989	oxidoreductase activity
CWC22_RS18530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CWC22_RS18535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS18540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS18545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS18555	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWC22_RS18575	COG0640	Transcriptional regulator
CWC22_RS18595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWC22_RS18605	COG0668	transmembrane transport
CWC22_RS18610	COG0204	Acyl-transferase
CWC22_RS18615	COG0204	Acyl-transferase
CWC22_RS18620	COG1166	arginine decarboxylase activity
CWC22_RS18625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWC22_RS18630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWC22_RS18635	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CWC22_RS18640	COG3385	transposase activity
CWC22_RS18645	COG0545	Peptidyl-prolyl cis-trans isomerase
CWC22_RS18655	COG2900	Belongs to the SlyX family
CWC22_RS18660	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CWC22_RS18665	COG0488	(ABC) transporter
CWC22_RS18675	COG0429	hydrolase of the alpha beta-hydrolase fold
CWC22_RS18680	COG3089	Belongs to the UPF0270 family
CWC22_RS18710	COG1218	3'(2'),5'-bisphosphate nucleotidase
CWC22_RS18715	COG0494	nUDIX hydrolase
CWC22_RS18720	COG1011	Hydrolase
CWC22_RS18770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWC22_RS18795	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CWC22_RS18805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWC22_RS18820	COG0537	adenosine 5'-monophosphoramidase activity
CWC22_RS18840	COG0840	transmembrane signaling receptor activity
CWC22_RS18850	COG0436	Aminotransferase
CWC22_RS18855	COG0235	Class ii aldolase
CWC22_RS18860	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CWC22_RS18865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CWC22_RS18870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CWC22_RS18875	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CWC22_RS18890	COG2226	methyltransferase
CWC22_RS18910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWC22_RS18915	COG0805	protein transport
CWC22_RS18925	COG0084	hydrolase, TatD family'
CWC22_RS18930	COG2203	Gaf domain
CWC22_RS18930	COG5001	Diguanylate cyclase
CWC22_RS18930	COG4251	negative regulation of phosphorylation
CWC22_RS18930	COG3706	GGDEF domain
CWC22_RS18950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWC22_RS18955	COG2610	gluconate transmembrane transporter activity
CWC22_RS18970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWC22_RS18980	COG4681	YaeQ
CWC22_RS18995	COG0783	Belongs to the Dps family
CWC22_RS19005	COG1770	oligopeptidase
CWC22_RS19020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC22_RS19030	COG1136	(ABC) transporter
CWC22_RS19030	COG0577	efflux transmembrane transporter activity
CWC22_RS19090	COG2204	response regulator
CWC22_RS19095	COG0676	glucose-6-phosphate 1-epimerase activity
CWC22_RS19100	COG0840	transmembrane signaling receptor activity
CWC22_RS19115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWC22_RS19140	COG1234	tRNA 3'-trailer cleavage
CWC22_RS19145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CWC22_RS19150	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWC22_RS19165	COG1162	GTPase activity
CWC22_RS19170	COG2204	response regulator
CWC22_RS19180	COG4191	Histidine kinase
CWC22_RS19180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWC22_RS19275	COG0464	growth
CWC22_RS19310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWC22_RS19315	COG1349	DNA-binding transcription factor activity
CWC22_RS19320	COG3279	Response regulator of the LytR AlgR family
CWC22_RS19345	COG1388	LysM domain
CWC22_RS19345	COG0741	lytic transglycosylase activity
CWC22_RS19360	COG1917	Cupin 2, conserved barrel domain protein
CWC22_RS19360	COG4977	sequence-specific DNA binding
CWC22_RS19365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CWC22_RS19375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWC22_RS19415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWC22_RS19420	COG4191	Histidine kinase
CWC22_RS19425	COG2204	response regulator
CWC22_RS19445	COG0577	efflux transmembrane transporter activity
CWC22_RS19445	COG1136	(ABC) transporter
CWC22_RS19455	COG0367	asparagine synthase
CWC22_RS19480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWC22_RS19485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWC22_RS19490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWC22_RS19495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWC22_RS19500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWC22_RS19505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWC22_RS19515	COG0356	it plays a direct role in the translocation of protons across the membrane
CWC22_RS19525	COG1475	DNA binding
CWC22_RS19530	COG1192	Involved in chromosome partitioning
CWC22_RS19535	COG0357	Ribosomal RNA small subunit methyltransferase G
CWC22_RS19540	COG0445	tRNA wobble uridine modification
CWC22_RS19545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CWC22_RS19555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWC22_RS19575	COG4232	protein-disulfide reductase activity
CWC22_RS19580	COG0706	membrane insertase activity
CWC22_RS19585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWC22_RS19590	COG0594	ribonuclease P activity
CWC22_RS19595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWC22_RS19615	COG1611	Belongs to the LOG family
CWC22_RS19620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWC22_RS19635	COG0473	3-isopropylmalate dehydrogenase activity
CWC22_RS19645	COG0028	Belongs to the TPP enzyme family
CWC22_RS19660	COG0415	Belongs to the DNA photolyase family
CWC22_RS19670	COG3695	enzyme binding
CWC22_RS19675	COG0583	DNA-binding transcription factor activity
CWC22_RS19690	COG1187	pseudouridine synthase activity
CWC22_RS19700	COG2311	Membrane
CWC22_RS19705	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CWC22_RS19720	COG0058	SHG alpha-glucan phosphorylase activity
CWC22_RS19730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CWC22_RS19735	COG1640	4-alpha-glucanotransferase
CWC22_RS19760	COG3138	arginine N-succinyltransferase
CWC22_RS19780	COG1234	tRNA 3'-trailer cleavage
CWC22_RS19790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWC22_RS19795	COG0625	glutathione transferase activity
CWC22_RS19800	COG0513	Belongs to the DEAD box helicase family
CWC22_RS19805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWC22_RS19825	COG4771	TonB-dependent receptor
CWC22_RS19835	COG1879	ABC-type sugar transport system periplasmic component
CWC22_RS19855	COG1960	acyl-CoA dehydrogenase activity
CWC22_RS19860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWC22_RS19865	COG0484	heat shock protein binding
CWC22_RS19870	COG0443	Heat shock 70 kDa protein
CWC22_RS19880	COG2995	paraquat-inducible protein a
CWC22_RS19885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CWC22_RS19885	COG3008	intermembrane lipid transfer
CWC22_RS19895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWC22_RS19905	COG0737	Belongs to the 5'-nucleotidase family
CWC22_RS19950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CWC22_RS19955	COG0625	glutathione transferase activity
CWC22_RS19970	COG4628	conserved protein (DUF2132)
CWC22_RS19980	COG0010	Belongs to the arginase family
CWC22_RS19990	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CWC22_RS19995	COG0295	cytidine deaminase activity
CWC22_RS20005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CWC22_RS20015	COG0471	metal ion transport
CWC22_RS20025	COG3227	Zinc metalloprotease (Elastase)
CWC22_RS20050	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CWC22_RS20060	COG3264	Mechanosensitive ion channel
CWC22_RS20060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CWC22_RS20070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWC22_RS20075	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWC22_RS20100	COG3279	Response regulator of the LytR AlgR family
CWC22_RS20105	COG3275	phosphorelay sensor kinase activity
CWC22_RS20125	COG0457	Tetratricopeptide repeat
CWC22_RS20135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CWC22_RS20140	COG1435	thymidine kinase activity
CWC22_RS20150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWC22_RS20155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CWC22_RS20160	COG2193	ferroxidase activity
CWC22_RS20170	COG2906	2 iron, 2 sulfur cluster binding
CWC22_RS20180	COG2205	protein histidine kinase activity
CWC22_RS20180	COG0784	Response regulator, receiver
CWC22_RS20245	COG1132	(ABC) transporter
CWC22_RS20260	COG0515	serine threonine protein kinase
CWC22_RS20280	COG1794	racemase activity, acting on amino acids and derivatives
CWC22_RS20295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CWC22_RS20350	COG1061	Type III restriction enzyme res subunit
CWC22_RS20365	COG0556	nucleotide-excision repair
CWC22_RS20450	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CWC22_RS20460	COG3829	transcription factor binding
CWC22_RS20465	COG0655	NAD(P)H dehydrogenase (quinone) activity
CWC22_RS20495	COG0745	RESPONSE REGULATOR receiver
CWC22_RS20535	COG4771	TonB-dependent receptor
CWC22_RS20550	COG0494	nUDIX hydrolase
CWC22_RS20600	COG1253	flavin adenine dinucleotide binding
CWC22_RS20640	COG3634	alkyl hydroperoxide reductase activity
CWC22_RS20655	COG5001	Diguanylate cyclase
CWC22_RS20655	COG3300	MHYT domain
CWC22_RS20670	COG0640	Transcriptional regulator
CWC22_RS20680	COG1506	peptidase
CWC22_RS20680	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS20680	COG4946	Tricorn protease homolog
CWC22_RS20685	COG1609	Transcriptional regulator
CWC22_RS20710	COG4946	Tricorn protease homolog
CWC22_RS20710	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS20710	COG1506	peptidase
CWC22_RS20750	COG4991	sh3 domain protein
CWC22_RS20750	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWC22_RS20750	COG3103	Sh3 type 3 domain protein
CWC22_RS20770	COG2814	Major facilitator Superfamily
CWC22_RS20775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CWC22_RS20830	COG1301	dicarboxylic acid transport
CWC22_RS20850	COG5002	protein histidine kinase activity
CWC22_RS20850	COG2205	protein histidine kinase activity
CWC22_RS20850	COG0784	Response regulator, receiver
CWC22_RS20870	COG2193	ferroxidase activity
CWC22_RS20880	COG3604	Transcriptional regulator
CWC22_RS20895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWC22_RS20895	COG1017	nitric oxide dioxygenase activity
CWC22_RS20900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWC22_RS20910	COG2205	protein histidine kinase activity
CWC22_RS20910	COG0784	Response regulator, receiver
CWC22_RS20940	COG1136	(ABC) transporter
CWC22_RS20965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC22_RS20980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWC22_RS21000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWC22_RS21010	COG4181	ATPase activity
CWC22_RS21075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CWC22_RS21110	COG0076	glutamate decarboxylase activity
CWC22_RS21115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWC22_RS21145	COG2378	regulation of single-species biofilm formation
CWC22_RS21190	COG0745	RESPONSE REGULATOR receiver
CWC22_RS21215	COG2205	protein histidine kinase activity
CWC22_RS21230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CWC22_RS21310	COG1944	ATP diphosphatase activity
CWC22_RS21320	COG0583	DNA-binding transcription factor activity
CWC22_RS21325	COG2814	Major facilitator Superfamily
CWC22_RS21330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWC22_RS21350	COG2205	protein histidine kinase activity
CWC22_RS21360	COG2204	response regulator
CWC22_RS21370	COG0840	transmembrane signaling receptor activity
CWC22_RS21405	COG1770	oligopeptidase
CWC22_RS21430	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CWC22_RS21440	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS21440	COG4946	Tricorn protease homolog
CWC22_RS21440	COG1506	peptidase
CWC22_RS21450	COG3437	response regulator, receiver
CWC22_RS21455	COG0745	RESPONSE REGULATOR receiver
CWC22_RS21475	COG0346	lactoylglutathione lyase activity
CWC22_RS21500	COG0123	including yeast histone deacetylase and acetoin utilization protein
CWC22_RS21525	COG4999	Histidine kinase
CWC22_RS21525	COG3850	Histidine kinase
CWC22_RS21525	COG3437	response regulator, receiver
CWC22_RS21525	COG2205	protein histidine kinase activity
CWC22_RS21530	COG1858	cytochrome C peroxidase
CWC22_RS21550	COG3706	GGDEF domain
CWC22_RS21575	COG4682	membrane
CWC22_RS21635	COG0739	heme binding
CWC22_RS21650	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWC22_RS21655	COG1605	Chorismate mutase
CWC22_RS21665	COG1506	peptidase
CWC22_RS21665	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS21670	COG0384	phenazine biosynthesis protein PhzF
CWC22_RS21680	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS21680	COG1506	peptidase
CWC22_RS21680	COG4946	Tricorn protease homolog
CWC22_RS21700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWC22_RS21725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CWC22_RS21740	COG0644	oxidoreductase
CWC22_RS21750	COG0823	Involved in the tonB-independent uptake of proteins
CWC22_RS21820	COG2205	protein histidine kinase activity
CWC22_RS21825	COG0745	RESPONSE REGULATOR receiver
CWC22_RS21845	COG4585	Histidine kinase
CWC22_RS21850	COG2197	response regulator
CWC22_RS21890	COG0813	purine-nucleoside phosphorylase activity
CWC22_RS21895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWC22_RS21900	COG0572	uridine kinase
CWC22_RS21905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CWC22_RS21915	COG3409	Peptidoglycan-binding domain 1 protein
CWC22_RS21915	COG3757	hydrolase, family 25
CWC22_RS21925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWC22_RS21945	COG4771	TonB-dependent receptor
CWC22_RS21950	COG0385	Bile acid
CWC22_RS22045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWC22_RS22065	COG2828	Protein conserved in bacteria
CWC22_RS22070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWC22_RS22075	COG0372	Belongs to the citrate synthase family
CWC22_RS22080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CWC22_RS22085	COG1802	Transcriptional regulator
CWC22_RS22090	COG4771	TonB-dependent receptor
CWC22_RS22110	COG1515	deoxyribonuclease V activity
CWC22_RS22165	COG1278	Cold shock
CWC22_RS22175	COG4191	Histidine kinase
CWC22_RS22175	COG0784	Response regulator, receiver
CWC22_RS22195	COG0642	Histidine kinase
CWC22_RS22220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWC22_RS22255	COG4336	lyase activity
CWC22_RS22265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWC22_RS22285	COG0745	RESPONSE REGULATOR receiver
CWC22_RS22290	COG2205	protein histidine kinase activity
CWC22_RS22305	COG0577	efflux transmembrane transporter activity
CWC22_RS22305	COG1136	(ABC) transporter
CWC22_RS22310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWC22_RS22320	COG0583	DNA-binding transcription factor activity
CWC22_RS22350	COG0745	RESPONSE REGULATOR receiver
CWC22_RS22365	COG1940	carbohydrate kinase activity
CWC22_RS22370	COG0738	Major facilitator superfamily
CWC22_RS22380	COG0662	Cupin 2, conserved barrel domain protein
CWC22_RS22380	COG2207	Transcriptional regulator
CWC22_RS22385	COG2602	Beta-lactamase
CWC22_RS22390	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CWC22_RS22395	COG4181	ATPase activity
CWC22_RS22500	COG2205	protein histidine kinase activity
CWC22_RS22505	COG0745	RESPONSE REGULATOR receiver
CWC22_RS22535	COG1858	cytochrome C peroxidase
CWC22_RS22540	COG0784	Response regulator, receiver
CWC22_RS22540	COG5002	protein histidine kinase activity
CWC22_RS22560	COG0583	DNA-binding transcription factor activity
CWC22_RS22575	COG2205	protein histidine kinase activity
CWC22_RS22580	COG0745	RESPONSE REGULATOR receiver
CWC22_RS22615	COG0438	transferase activity, transferring glycosyl groups
CWC22_RS22620	COG0562	UDP-galactopyranose mutase
CWC22_RS22625	COG2205	protein histidine kinase activity
CWC22_RS22645	COG4771	TonB-dependent receptor
CWC22_RS22720	COG1518	maintenance of DNA repeat elements
CWC22_RS22785	COG0702	epimerase
CWC22_RS22790	COG0583	DNA-binding transcription factor activity
CWC22_RS22795	COG2259	Doxx family
CWC22_RS22855	COG1741	Belongs to the pirin family
CWC22_RS22860	COG0435	Glutathione S-transferase
CWC22_RS22885	COG3038	cytochrome b561
CWC22_RS22900	COG3852	Histidine kinase
CWC22_RS22910	COG1136	(ABC) transporter
CWC22_RS22910	COG0577	efflux transmembrane transporter activity
CWC22_RS22915	COG0577	efflux transmembrane transporter activity
CWC22_RS22915	COG1136	(ABC) transporter
CWC22_RS22990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWC22_RS23005	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CWC22_RS23005	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CWC22_RS23020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CWC22_RS23065	COG0514	ATP-dependent DNA helicase (RecQ)
CWC22_RS23080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWC22_RS23105	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CWC22_RS23120	COG0730	response to heat
CWC22_RS23170	COG3706	GGDEF domain
CWC22_RS23190	COG1280	lysine exporter protein (LysE YggA)
CWC22_RS23210	COG0583	DNA-binding transcription factor activity
CWC22_RS23265	COG1215	transferase activity, transferring glycosyl groups
CWC22_RS23285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWC22_RS23310	COG1741	Belongs to the pirin family
CWC22_RS23320	COG0625	glutathione transferase activity
CWC22_RS23325	COG0583	DNA-binding transcription factor activity
CWC22_RS23330	COG1028	Short-chain dehydrogenase reductase Sdr
CWC22_RS23335	COG4771	TonB-dependent receptor
CWC22_RS23345	COG1012	belongs to the aldehyde dehydrogenase family
CWC22_RS23385	COG0217	transcriptional regulatory protein
CWC22_RS23395	COG0259	pyridoxamine-phosphate oxidase activity
CWC22_RS23405	COG0840	transmembrane signaling receptor activity
CWC22_RS23460	COG0583	DNA-binding transcription factor activity
CWC22_RS23470	COG0339	signal peptide processing
CWC22_RS23475	COG0745	RESPONSE REGULATOR receiver
CWC22_RS23480	COG0454	-acetyltransferase
CWC22_RS23490	COG1234	tRNA 3'-trailer cleavage
CWC22_RS23510	COG5002	protein histidine kinase activity
CWC22_RS23515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CWC22_RS23515	COG0678	peroxiredoxin activity
CWC22_RS23560	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWC22_RS23560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWC22_RS23570	COG0583	DNA-binding transcription factor activity
CWC22_RS23580	COG0583	DNA-binding transcription factor activity
CWC22_RS23615	COG4977	sequence-specific DNA binding
CWC22_RS23615	COG1917	Cupin 2, conserved barrel domain protein
CWC22_RS23620	COG0242	peptide deformylase activity
CWC22_RS23625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWC22_RS23630	COG0583	DNA-binding transcription factor activity
CWC22_RS23665	COG1573	uracil-dna glycosylase
CWC22_RS23700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWC22_RS23720	COG0346	lactoylglutathione lyase activity
CWC22_RS23725	COG0456	acetyltransferase
CWC22_RS23730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CWC22_RS23775	COG3708	Transcriptional regulator
CWC22_RS23775	COG2207	Transcriptional regulator
CWC22_RS23815	COG0420	3'-5' exonuclease activity
CWC22_RS23845	COG0071	Belongs to the small heat shock protein (HSP20) family
CWC22_RS23865	COG0071	Belongs to the small heat shock protein (HSP20) family
CWC22_RS23870	COG4651	solute:proton antiporter activity
CWC22_RS23870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWC22_RS23875	COG0589	response to stress
CWC22_RS23905	COG2205	protein histidine kinase activity
CWC22_RS23915	COG3385	transposase activity
CWC22_RS23925	COG1322	Protein conserved in bacteria
CWC22_RS23930	COG0745	RESPONSE REGULATOR receiver
CWC22_RS23940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWC22_RS23970	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CWC22_RS23975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWC22_RS23980	COG0574	Belongs to the PEP-utilizing enzyme family
CWC22_RS23980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWC22_RS23990	COG0277	FAD linked oxidase domain protein
CWC22_RS23990	COG0247	lactate metabolic process
CWC22_RS24005	COG1404	Belongs to the peptidase S8 family
CWC22_RS24010	COG3291	Pkd domain containing protein
CWC22_RS24020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWC22_RS24045	COG0848	biopolymer transport protein
CWC22_RS24050	COG0811	peptide transport
CWC22_RS24055	COG0811	peptide transport
CWC22_RS24075	COG3537	Alpha-1,2-mannosidase
CWC22_RS24090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWC22_RS24100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CWC22_RS24105	COG2983	Belongs to the UPF0260 family
CWC22_RS24115	COG2205	protein histidine kinase activity
CWC22_RS24120	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWC22_RS24130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CWC22_RS24175	COG0840	transmembrane signaling receptor activity
CWC22_RS24180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CWC22_RS24185	COG3385	transposase activity
CWC22_RS24190	COG5001	Diguanylate cyclase
CWC22_RS24190	COG3300	MHYT domain
CWC22_RS24195	COG3706	GGDEF domain
CWC22_RS24225	COG1271	oxidase subunit
CWC22_RS24230	COG1294	oxidase, subunit
CWC22_RS24235	COG2951	lytic endotransglycosylase activity
CWC22_RS24240	COG3100	YcgL domain-containing protein
CWC22_RS24245	COG0850	regulation of cytokinetic process
CWC22_RS24250	COG2894	cell division
CWC22_RS24255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CWC22_RS24265	COG0318	PFAM AMP-dependent synthetase and ligase
CWC22_RS24275	COG1785	Belongs to the alkaline phosphatase family
CWC22_RS24280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWC22_RS24295	COG1199	ATP-dependent helicase activity
CWC22_RS24335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWC22_RS24340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWC22_RS24345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWC22_RS24350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CWC22_RS24350	COG0131	Imidazoleglycerol-phosphate dehydratase
CWC22_RS24355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWC22_RS24360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWC22_RS24365	COG0107	imidazoleglycerol-phosphate synthase activity
CWC22_RS24370	COG0140	phosphoribosyl-ATP diphosphatase activity
CWC22_RS24370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP