locus-tag	class	description
HYD28_RS00005	ENOG41082RQ	UPF0102 protein
HYD28_RS00015	ENOG4105W4M	Transport-associated protein
HYD28_RS00020	ENOG4105KB2	stringent starvation protein b
HYD28_RS00025	ENOG4107MKT	Stringent starvation protein a
HYD28_RS00030	ENOG4105EIX	cytochrome c1
HYD28_RS00035	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HYD28_RS00040	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HYD28_RS00050	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HYD28_RS00055	ENOG4105N42	UPF0307 protein
HYD28_RS00065	ENOG4105C9K	Endothelin-converting enzyme 1
HYD28_RS00070	ENOG4105M6F	mutator MutT protein
HYD28_RS00075	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HYD28_RS00105	ENOG4105CY0	Metallo-Beta-Lactamase
HYD28_RS00115	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HYD28_RS00135	ENOG4105D3Q	Sugar transferase
HYD28_RS00150	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HYD28_RS00160	ENOG4105C5E	polysaccharide biosynthesis protein
HYD28_RS00190	ENOG4107QQG	Dehydrogenase
HYD28_RS00195	ENOG4105D75	Capsular exopolysaccharide family
HYD28_RS00200	ENOG4107ZF2	Phosphatase
HYD28_RS00205	ENOG4105DAY	polysaccharide export protein
HYD28_RS00210	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HYD28_RS00220	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HYD28_RS00225	ENOG4105CPK	Glycosyl transferase (Group 1
HYD28_RS00250	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HYD28_RS00255	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HYD28_RS00265	ENOG4105PSV	Polysaccharide Biosynthesis Protein
HYD28_RS00275	ENOG4108UT6	Transferase hexapeptide repeat containing protein
HYD28_RS00330	ENOG4105D7Q	type ii secretion system
HYD28_RS00335	ENOG4107QHF	type ii secretion system protein e
HYD28_RS00340	ENOG4108VAU	general secretion pathway protein G
HYD28_RS00350	ENOG4107V1M	polysaccharide export protein
HYD28_RS00355	ENOG4108NE3	Salt-induced outer membrane protein
HYD28_RS00360	ENOG4105D64	Mechanosensitive ion channel
HYD28_RS00395	ENOG4105D29	Helix-turn-helix type 11 domain protein
HYD28_RS00400	ENOG4108F5E	vimentin
HYD28_RS00435	ENOG4108ZIT	Ferredoxin, 2FE-2S
HYD28_RS00440	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HYD28_RS00445	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HYD28_RS00450	ENOG4108Z4V	iron-sulfur cluster assembly
HYD28_RS00455	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HYD28_RS00460	ENOG4105C3J	Cysteine desulfurase
HYD28_RS00475	ENOG4105ECY	inositol monophosphatase
HYD28_RS00485	ENOG4105BZU	Histidine kinase
HYD28_RS00500	ENOG4105TW1	Carbohydrate-selective porin OprB
HYD28_RS00510	ENOG4105DEI	Mannitol dehydrogenase
HYD28_RS00515	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HYD28_RS00520	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HYD28_RS00525	ENOG4105VIE	preprotein translocase, subunit YajC
HYD28_RS00530	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HYD28_RS00535	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HYD28_RS00540	ENOG4105BZU	Histidine kinase
HYD28_RS00565	ENOG4105C5Q	Transcriptional regulator
HYD28_RS00570	ENOG4105CJ3	phosphate transporter
HYD28_RS00575	ENOG4107IX6	phosphate transport regulator
HYD28_RS00585	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HYD28_RS00590	ENOG4105C8U	phosphate abc transporter
HYD28_RS00595	ENOG4105C8U	phosphate abc transporter
HYD28_RS00605	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HYD28_RS00610	ENOG4105C9X	ppx gppa phosphatase
HYD28_RS00620	ENOG4108IJF	Heavy metal efflux pump, CzcA
HYD28_RS00625	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
HYD28_RS00640	ENOG4105F1S	paraquat-inducible protein a
HYD28_RS00645	ENOG4105D58	Diguanylate phosphodiesterase
HYD28_RS00655	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HYD28_RS00665	ENOG4105D6S	protein involved in catabolism of external DNA
HYD28_RS00675	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HYD28_RS00685	ENOG4105E9H	Lytic Murein transglycosylase
HYD28_RS00690	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HYD28_RS00710	ENOG4105CXK	mandelate racemase muconate lactonizing
HYD28_RS00715	ENOG4105MP9	class II Aldolase
HYD28_RS00720	ENOG4105VBD	cytochrome C, class I
HYD28_RS00725	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
HYD28_RS00730	ENOG4105D94	Major Facilitator Superfamily
HYD28_RS00735	ENOG4108ZQX	ybak prolyl-trna synthetase
HYD28_RS00750	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HYD28_RS00765	ENOG4108UV7	flagellar protein motX
HYD28_RS00770	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HYD28_RS00775	ENOG4105EPW	hflc protein
HYD28_RS00780	ENOG4107QJR	hflk protein
HYD28_RS00785	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HYD28_RS00790	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HYD28_RS00795	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HYD28_RS00800	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HYD28_RS00805	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HYD28_RS00810	ENOG4105K8N	protein family UPF0079, ATPase
HYD28_RS00815	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HYD28_RS00820	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HYD28_RS00825	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HYD28_RS00830	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HYD28_RS00835	ENOG4105VF7	tolerance protein
HYD28_RS00840	ENOG4105FS0	cytoplasmic membrane protein
HYD28_RS00845	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HYD28_RS00850	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HYD28_RS00860	ENOG4105BZU	Histidine kinase
HYD28_RS00865	ENOG41067QW	Transcriptional regulator
HYD28_RS00875	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HYD28_RS00880	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
HYD28_RS00885	ENOG4108UKZ	OsmC family
HYD28_RS00895	ENOG4105C26	Dehydrogenase
HYD28_RS00905	ENOG4105C8Y	Acetylornithine aminotransferase
HYD28_RS00915	ENOG4105DDQ	anthranilate synthase
HYD28_RS00930	ENOG4105E0F	Histidine kinase
HYD28_RS00940	ENOG4108RRZ	Transcription elongation factor GreB
HYD28_RS00955	ENOG4105BZM	domain protein
HYD28_RS00970	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HYD28_RS00975	ENOG4105MJ2	Competence protein
HYD28_RS00985	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
HYD28_RS00995	ENOG4107R73	Mate efflux family protein
HYD28_RS01000	ENOG4107BJW	polysaccharide deacetylase
HYD28_RS01005	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HYD28_RS01010	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
HYD28_RS01015	ENOG4105BZU	Histidine kinase
HYD28_RS01020	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS01025	ENOG4108V3W	Chemotaxis protein, CheW
HYD28_RS01030	ENOG4105CBS	Chea signal transduction histidine kinase
HYD28_RS01035	ENOG4108VYJ	response regulator receiver protein
HYD28_RS01045	ENOG4108ZX6	Electron transport protein SCO1 SenC
HYD28_RS01050	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HYD28_RS01075	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HYD28_RS01085	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HYD28_RS01095	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HYD28_RS01100	ENOG4105KA0	thioesterase Superfamily protein
HYD28_RS01135	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HYD28_RS01145	ENOG4108JUA	Transcriptional regulator
HYD28_RS01155	ENOG4108YYH	Nadph-dependent fmn reductase
HYD28_RS01175	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HYD28_RS01180	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HYD28_RS01185	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HYD28_RS01190	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HYD28_RS01205	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HYD28_RS01210	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HYD28_RS01215	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HYD28_RS01220	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HYD28_RS01225	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HYD28_RS01240	ENOG4105VKU	nucleicacid-binding protein
HYD28_RS01245	ENOG4105C5H	ABC transporter
HYD28_RS01260	ENOG4105DNZ	Alpha Beta Hydrolase
HYD28_RS01265	ENOG4105YP7	UPF0270 protein
HYD28_RS01285	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HYD28_RS01310	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HYD28_RS01315	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HYD28_RS01335	ENOG4105K59	histidine triad (HIT) protein
HYD28_RS01345	ENOG4105BZU	Histidine kinase
HYD28_RS01350	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HYD28_RS01355	ENOG41083MP	50s ribosomal protein l29
HYD28_RS01360	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HYD28_RS01365	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HYD28_RS01370	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HYD28_RS01375	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HYD28_RS01380	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYD28_RS01385	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HYD28_RS01390	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HYD28_RS01395	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HYD28_RS01405	ENOG4105E55	glycerol-3-phosphate acyltransferase
HYD28_RS01410	ENOG4105C29	acyl-CoA thioesterase
HYD28_RS01435	ENOG4105CRW	Short chain fatty acid transporter
HYD28_RS01445	ENOG4105BZU	Histidine kinase
HYD28_RS01460	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HYD28_RS01515	ENOG4105RHY	Pfam:UPF0157
HYD28_RS01545	ENOG4105EN6	Membrane
HYD28_RS01560	ENOG4105CHM	Aminotransferase
HYD28_RS01565	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
HYD28_RS01570	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
HYD28_RS01575	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
HYD28_RS01585	ENOG4108M3R	transcriptional activator CadC
HYD28_RS01590	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HYD28_RS01595	ENOG4105CT5	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity)
HYD28_RS01600	ENOG4105CBC	glutamate synthase
HYD28_RS01615	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HYD28_RS01625	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HYD28_RS01630	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HYD28_RS01635	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HYD28_RS01640	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HYD28_RS01650	ENOG4105F8V	Hydrolase, tatD family
HYD28_RS01660	ENOG4105D52	delta-aminolevulinic acid dehydratase
HYD28_RS01680	ENOG4108MRH	transcriptional regulatory protein
HYD28_RS01685	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HYD28_RS01725	ENOG4105DWV	Homoserine O-trans-acetylase
HYD28_RS01730	ENOG4105CY2	Citrate transporter
HYD28_RS01765	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS01770	ENOG4105BZU	Histidine kinase
HYD28_RS01790	ENOG4105BZU	Histidine kinase
HYD28_RS01800	ENOG4105BZU	Histidine kinase
HYD28_RS01815	ENOG4108VWS	Yaeq family
HYD28_RS01830	ENOG4108RMU	ferritin dps family protein
HYD28_RS01840	ENOG4105CUG	Oligopeptidase b
HYD28_RS01845	ENOG4108M1A	Chitin-binding protein
HYD28_RS01895	ENOG4105DSB	aldose 1-epimerase
HYD28_RS01935	ENOG4108VBZ	doxx family
HYD28_RS01940	ENOG4105EUB	pirin domain protein
HYD28_RS01945	ENOG4108NUU	Transcriptional regulator
HYD28_RS01960	ENOG4105FGE	Short-chain dehydrogenase reductase Sdr
HYD28_RS01965	ENOG4107EJG	GntR family transcriptional regulator
HYD28_RS01975	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HYD28_RS01980	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HYD28_RS01995	ENOG4105CT4	transporter
HYD28_RS02000	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HYD28_RS02010	ENOG4106Z5D	Glycoside Hydrolase Family 43
HYD28_RS02035	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HYD28_RS02040	ENOG4107VXZ	Hydrolase
HYD28_RS02060	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HYD28_RS02065	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HYD28_RS02075	ENOG4105E0K	tonB-dependent siderophore receptor
HYD28_RS02105	ENOG4107ENK	receptor
HYD28_RS02120	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS02135	ENOG4105BZU	Histidine kinase
HYD28_RS02140	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HYD28_RS02145	ENOG410804X	Transcriptional regulator
HYD28_RS02160	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HYD28_RS02175	ENOG4108UW5	maltose o-acetyltransferase
HYD28_RS02200	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HYD28_RS02205	ENOG4105Y49	secretion protein, HlyD family
HYD28_RS02210	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS02215	ENOG4105BZU	Histidine kinase
HYD28_RS02255	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HYD28_RS02260	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HYD28_RS02265	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HYD28_RS02270	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HYD28_RS02275	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HYD28_RS02280	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HYD28_RS02285	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HYD28_RS02290	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HYD28_RS02295	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HYD28_RS02305	ENOG4105FA0	parb-like partition protein
HYD28_RS02310	ENOG4107QJE	Chromosome Partitioning Protein
HYD28_RS02315	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HYD28_RS02320	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HYD28_RS02330	ENOG4108JZP	Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity)
HYD28_RS02335	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HYD28_RS02340	ENOG4105E0K	tonB-dependent siderophore receptor
HYD28_RS02350	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HYD28_RS02355	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HYD28_RS02360	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HYD28_RS02365	ENOG4105VG0	50S ribosomal protein l34
HYD28_RS02370	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HYD28_RS02375	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HYD28_RS02385	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HYD28_RS02390	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HYD28_RS02395	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HYD28_RS02405	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HYD28_RS02410	ENOG4105CHU	acetyl-coa acetyltransferase
HYD28_RS02415	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS02420	ENOG4107SC1	transglycosylase
HYD28_RS02430	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HYD28_RS02435	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HYD28_RS02465	ENOG4105C1A	potassium transporter peripheral membrane
HYD28_RS02475	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HYD28_RS02480	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HYD28_RS02490	ENOG4105C79	DNA protecting protein DprA
HYD28_RS02495	ENOG4108RPN	Protein smg homolog
HYD28_RS02500	ENOG4108WI1	Dna topoisomerase
HYD28_RS02505	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HYD28_RS02510	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HYD28_RS02520	ENOG4108N3W	hemolysin secretion protein
HYD28_RS02525	ENOG4108Z18	K06886 hemoglobin
HYD28_RS02530	ENOG4105E2X	shikimate dehydrogenase
HYD28_RS02540	ENOG4108Z0R	Transferase
HYD28_RS02580	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HYD28_RS02620	ENOG4105C9Q	fumarate hydratase class II
HYD28_RS02650	ENOG4108YXU	transcriptional regulator AsnC family
HYD28_RS02690	ENOG4107TE5	Lipid kinase
HYD28_RS02700	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HYD28_RS02715	ENOG4108V06	Glutathione peroxidase
HYD28_RS02720	ENOG4105CC0	LysR family Transcriptional regulator
HYD28_RS02725	ENOG4108I6A	alcohol dehydrogenase
HYD28_RS02735	ENOG4108UMN	azlc family
HYD28_RS02755	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
HYD28_RS02760	ENOG4105CUG	Oligopeptidase b
HYD28_RS02765	ENOG4105BZU	Histidine kinase
HYD28_RS02770	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HYD28_RS02790	ENOG4105W39	Membrane
HYD28_RS02795	ENOG4105KKP	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase
HYD28_RS02800	ENOG4105EUJ	GTP cyclohydrolase i
HYD28_RS02805	ENOG410642E	Short chain dehydrogenase
HYD28_RS02815	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HYD28_RS02825	ENOG4105BZU	Histidine kinase
HYD28_RS02835	ENOG4105BZU	Histidine kinase
HYD28_RS02845	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HYD28_RS02875	ENOG4105FE9	pseudouridine synthase
HYD28_RS02900	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HYD28_RS02905	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HYD28_RS02910	ENOG4105CT0	Protein of unknown function, DUF484
HYD28_RS02915	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HYD28_RS02920	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HYD28_RS02930	ENOG4105XQ6	frataxin-like protein
HYD28_RS02935	ENOG4106CJB	Phospholipase Carboxylesterase
HYD28_RS02945	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HYD28_RS02960	ENOG4105BZU	Histidine kinase
HYD28_RS02965	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HYD28_RS02975	ENOG4107QK7	reductase
HYD28_RS02980	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HYD28_RS02990	ENOG4105CKW	Inner membrane protein yedI
HYD28_RS03005	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS03015	ENOG4105BZU	Histidine kinase
HYD28_RS03020	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS03025	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HYD28_RS03035	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS03040	ENOG4105C9X	ppx gppa phosphatase
HYD28_RS03070	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HYD28_RS03075	ENOG4105C4R	Atp-dependent dna helicase
HYD28_RS03085	ENOG4105XTV	UPF0231 protein
HYD28_RS03100	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
HYD28_RS03105	ENOG4107RK2	ADP-ribose diphosphatase NudE
HYD28_RS03110	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HYD28_RS03145	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HYD28_RS03150	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HYD28_RS03155	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HYD28_RS03180	ENOG4107QM5	aconitate hydratase
HYD28_RS03210	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS03215	ENOG4105CUX	Signal transduction histidine kinase
HYD28_RS03225	ENOG4105C5F	glutamine synthetase
HYD28_RS03230	ENOG4105CI3	gtp-binding protein typa
HYD28_RS03240	ENOG4105D4M	Lactamase_B
HYD28_RS03250	ENOG4107S2Z	UPF0761 membrane protein
HYD28_RS03260	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HYD28_RS03265	ENOG4105I7M	spermidine synthase
HYD28_RS03270	ENOG4105SUU	thioesterase domain
HYD28_RS03275	ENOG4105HDD	phospholipase
HYD28_RS03285	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HYD28_RS03295	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HYD28_RS03305	ENOG4105CNG	UPF0061 protein
HYD28_RS03310	ENOG4105UYK	outer membrane protein a
HYD28_RS03315	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HYD28_RS03355	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS03360	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HYD28_RS03365	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HYD28_RS03370	ENOG4106HNH	Acyl-transferase
HYD28_RS03375	ENOG4106HNH	Acyl-transferase
HYD28_RS03380	ENOG4105CUY	Mechanosensitive ion channel
HYD28_RS03395	ENOG4105UYK	outer membrane protein a
HYD28_RS03400	ENOG4105BZ1	(ABC) transporter
HYD28_RS03445	ENOG41080HT	Transcriptional regulator, arsr family
HYD28_RS03465	ENOG4105M0Y	
HYD28_RS03475	ENOG4105QYK	bacteriophage lambda Bor protein homolog
HYD28_RS03485	ENOG4107RBB	ABC transporter, permease
HYD28_RS03490	ENOG4105C19	ABC transporter
HYD28_RS03495	ENOG4105CW7	secretion protein, HlyD family
HYD28_RS03505	ENOG4107RGM	aldo keto reductase
HYD28_RS03535	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HYD28_RS03540	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HYD28_RS03545	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYD28_RS03550	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HYD28_RS03555	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HYD28_RS03560	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HYD28_RS03565	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HYD28_RS03570	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HYD28_RS03575	ENOG4105VPB	50S ribosomal protein L30
HYD28_RS03580	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HYD28_RS03585	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HYD28_RS03595	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYD28_RS03605	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HYD28_RS03610	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HYD28_RS03615	ENOG4108ZT0	50S ribosomal protein l17
HYD28_RS03635	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HYD28_RS03645	ENOG4105VEJ	Heat shock protein
HYD28_RS03650	ENOG4108XKW	General secretion pathway protein C
HYD28_RS03660	ENOG4107QHF	type ii secretion system protein e
HYD28_RS03665	ENOG4105D7Q	type ii secretion system
HYD28_RS03670	ENOG4108VAU	general secretion pathway protein G
HYD28_RS03690	ENOG4108RTD	type II secretion system protein K
HYD28_RS03725	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HYD28_RS03730	ENOG4105E27	serine threonine protein kinase
HYD28_RS03735	ENOG4108Z33	Thiol disulfide Interchange Protein
HYD28_RS03740	ENOG4108Z33	Thiol disulfide Interchange Protein
HYD28_RS03745	ENOG4105EWC	Purine nucleoside phosphorylase
HYD28_RS03750	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HYD28_RS03760	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HYD28_RS03765	ENOG4105VFU	Rna-binding protein
HYD28_RS03795	ENOG4105C44	Serine transporter
HYD28_RS03805	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HYD28_RS03810	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HYD28_RS03820	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HYD28_RS03825	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HYD28_RS03830	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HYD28_RS03835	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HYD28_RS03860	ENOG4105PM1	preprotein translocase subunit SecE
HYD28_RS03865	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HYD28_RS03870	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HYD28_RS03875	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HYD28_RS03880	ENOG4108VZM	50s ribosomal protein L10
HYD28_RS03885	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HYD28_RS03890	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HYD28_RS03895	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HYD28_RS03900	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HYD28_RS03905	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HYD28_RS03910	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HYD28_RS03915	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HYD28_RS03920	ENOG4105G6Z	alkaline phosphatase
HYD28_RS03925	ENOG4105G6Z	alkaline phosphatase
HYD28_RS03955	ENOG4105BZU	Histidine kinase
HYD28_RS03965	ENOG4105DKW	ABC transporter
HYD28_RS03980	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
HYD28_RS03985	ENOG4105C01	Dihydroxy-acid dehydratase
HYD28_RS03990	ENOG4105C7B	Threonine dehydratase
HYD28_RS04005	ENOG41077A9	carbonic anhydrase
HYD28_RS04010	ENOG4105W0Z	cytoplasmic protein
HYD28_RS04015	ENOG4105C4R	Atp-dependent dna helicase
HYD28_RS04020	ENOG4105BZU	Histidine kinase
HYD28_RS04025	ENOG4105MPD	Cytochrome
HYD28_RS04035	ENOG4105C2M	dna polymerase I
HYD28_RS04040	ENOG4107IFA	Lipase (EC 3.1.1.3)
HYD28_RS04055	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HYD28_RS04060	ENOG4106RE7	Cytochrome
HYD28_RS04070	ENOG4105XCT	Protein of unknown function (DUF2489)
HYD28_RS04075	ENOG4105D4P	Coproporphyrinogen iii oxidase
HYD28_RS04100	ENOG4105CMR	udp-glucose 4-epimerase
HYD28_RS04120	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HYD28_RS04125	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HYD28_RS04130	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HYD28_RS04135	ENOG4107RBR	Receptor
HYD28_RS04150	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HYD28_RS04165	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HYD28_RS04175	ENOG4105D06	uba thif-type nad fad binding protein
HYD28_RS04180	ENOG4105DJ4	phosphatidylserine decarboxylase
HYD28_RS04185	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HYD28_RS04190	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HYD28_RS04215	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HYD28_RS04225	ENOG4105MYN	Zinc uptake regulation protein
HYD28_RS04230	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HYD28_RS04240	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HYD28_RS04245	ENOG41087YS	Phage shock protein A
HYD28_RS04285	ENOG4105BZU	Histidine kinase
HYD28_RS04290	ENOG4105CCT	upf0313 protein
HYD28_RS04295	ENOG4105CJW	magnesium transporter
HYD28_RS04300	ENOG41080Z8	PHOSPHOCARRIER protein
HYD28_RS04305	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HYD28_RS04310	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HYD28_RS04315	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HYD28_RS04320	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HYD28_RS04325	ENOG4108IUZ	ABC transporter
HYD28_RS04340	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HYD28_RS04345	ENOG4105C2X	Arabinose 5-phosphate isomerase
HYD28_RS04355	ENOG4105DHJ	ABC, transporter
HYD28_RS04360	ENOG4105CY3	ABC transporter, permease
HYD28_RS04365	ENOG4107PE3	Mammalian cell entry related domain protein
HYD28_RS04370	ENOG4105E3I	toluene tolerance
HYD28_RS04375	ENOG4105UE2	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
HYD28_RS04380	ENOG4105VFK	BolA family
HYD28_RS04385	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HYD28_RS04395	ENOG4105C0H	protease
HYD28_RS04405	ENOG4105D6Z	AFG1 family ATPase
HYD28_RS04410	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HYD28_RS04415	ENOG4108UJD	30S ribosomal protein S9
HYD28_RS04440	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS04445	ENOG4107SRH	Nad-dependent epimerase dehydratase
HYD28_RS04455	ENOG4105CI2	imidazolone-5-propionate hydrolase
HYD28_RS04460	ENOG4105BZU	Histidine kinase
HYD28_RS04470	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HYD28_RS04475	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
HYD28_RS04495	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HYD28_RS04500	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HYD28_RS04510	ENOG4105C25	Primosomal protein n'
HYD28_RS04515	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HYD28_RS04520	ENOG4105C6K	Malic enzyme
HYD28_RS04525	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HYD28_RS04530	ENOG4105C28	cystathionine
HYD28_RS04535	ENOG4105CFH	Aspartokinase
HYD28_RS04545	ENOG4105DFF	Rod shape-determining protein mreb
HYD28_RS04565	ENOG4105E4G	Type IV pilus
HYD28_RS04575	ENOG4105D49	3-dehydroquinate synthase
HYD28_RS04585	ENOG4105DFE	Dna adenine methylase
HYD28_RS04600	ENOG4105DJV	ribulose-phosphate 3-epimerase
HYD28_RS04605	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HYD28_RS04610	ENOG4105C31	Tryptophanyl-tRNA synthetase
HYD28_RS04635	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HYD28_RS04640	ENOG4107RDB	Major Facilitator
HYD28_RS04645	ENOG4108UUM	single-stranded DNA-binding protein
HYD28_RS04655	ENOG4105K6H	D-cysteine desulfhydrase
HYD28_RS04670	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HYD28_RS04675	ENOG4105VQ7	Rod shape-determining protein MreD
HYD28_RS04680	ENOG4108Z03	MAF-like protein
HYD28_RS04685	ENOG4105C03	ribonuclease
HYD28_RS04690	ENOG4105QD6	exported protein
HYD28_RS04700	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HYD28_RS04715	ENOG4105EQD	regulatoR
HYD28_RS04720	ENOG4105DC8	reductase
HYD28_RS04725	ENOG4105DGW	oligopeptidase A
HYD28_RS04730	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS04735	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
HYD28_RS04740	ENOG4108W2P	Methyl-accepting chemotaxis
HYD28_RS04750	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HYD28_RS04755	ENOG4105CBX	hi0933 family
HYD28_RS04760	ENOG4105BZU	Histidine kinase
HYD28_RS04770	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HYD28_RS04775	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HYD28_RS04780	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HYD28_RS04790	ENOG4105W5Q	DNA repair protein (RadC
HYD28_RS04795	ENOG4105KDC	50s ribosomal protein l28
HYD28_RS04800	ENOG4105W0E	50S ribosomal protein L33
HYD28_RS04805	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HYD28_RS04810	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HYD28_RS04815	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HYD28_RS04825	ENOG4105X0D	Fimbrial protein
HYD28_RS04865	ENOG4105CDU	Replicative dna helicase
HYD28_RS04870	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HYD28_RS04890	ENOG4108KN0	Choline kinase
HYD28_RS04905	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HYD28_RS04915	ENOG4105GR3	Histidine kinase
HYD28_RS04925	ENOG4105GNX	MltA-interacting MipA family protein
HYD28_RS04935	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HYD28_RS04940	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HYD28_RS04965	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HYD28_RS04970	ENOG4105FR1	rard protein
HYD28_RS04985	ENOG4105CVI	Transcriptional regulator
HYD28_RS04995	ENOG4105CB5	ATP-dependent DNA helicase recG
HYD28_RS05000	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HYD28_RS05005	ENOG4108VVK	transcriptional Regulator, AsnC
HYD28_RS05010	ENOG4105CU9	asparagine synthetase A
HYD28_RS05020	ENOG4105KME	endoribonuclease L-psp
HYD28_RS05025	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HYD28_RS05030	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HYD28_RS05035	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HYD28_RS05040	ENOG4105DSJ	YicC domain protein
HYD28_RS05045	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HYD28_RS05050	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HYD28_RS05075	ENOG4105CN1	protease
HYD28_RS05080	ENOG41063SB	peptidase
HYD28_RS05085	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HYD28_RS05090	ENOG4107YZP	Rhodanese domain protein
HYD28_RS05100	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HYD28_RS05105	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HYD28_RS05110	ENOG4105BZU	Histidine kinase
HYD28_RS05115	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HYD28_RS05125	ENOG4108EUD	Lysophospholipase
HYD28_RS05130	ENOG4105E0F	Histidine kinase
HYD28_RS05135	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HYD28_RS05145	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
HYD28_RS05150	ENOG4107QHF	type ii secretion system protein e
HYD28_RS05155	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HYD28_RS05160	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HYD28_RS05170	ENOG4105X0D	Fimbrial protein
HYD28_RS05175	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HYD28_RS05180	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HYD28_RS05185	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HYD28_RS05190	ENOG41073TP	transcriptional regulator
HYD28_RS05195	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HYD28_RS05200	ENOG4107QSN	dihydrolipoamide acetyltransferase
HYD28_RS05205	ENOG4107QN2	dihydrolipoyl dehydrogenase
HYD28_RS05210	ENOG4106IUH	DTW domain containing protein
HYD28_RS05235	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HYD28_RS05240	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HYD28_RS05245	ENOG4105EAH	synthase
HYD28_RS05250	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HYD28_RS05255	ENOG4105K46	50S ribosomal protein l27
HYD28_RS05260	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYD28_RS05275	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS05280	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HYD28_RS05285	ENOG4105NWN	ApaG protein
HYD28_RS05290	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HYD28_RS05295	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HYD28_RS05310	ENOG4105EHM	Aminoglycoside phosphotransferase
HYD28_RS05315	ENOG4108S0S	Nucleotidyl transferase
HYD28_RS05320	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HYD28_RS05330	ENOG4105D3G	Pseudouridine synthase
HYD28_RS05340	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HYD28_RS05345	ENOG4108IAB	Phoh family
HYD28_RS05350	ENOG4108IAB	Phoh family
HYD28_RS05405	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HYD28_RS05425	ENOG4105E3B	Multicopper oxidase
HYD28_RS05440	ENOG4105W1Y	Transcriptional regulator
HYD28_RS05445	ENOG4105C59	p-type ATPase
HYD28_RS05495	ENOG4105W1Y	Transcriptional regulator
HYD28_RS05505	ENOG4105PGM	cation diffusion facilitator family transporter
HYD28_RS05555	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
HYD28_RS05565	ENOG4105W1Y	Transcriptional regulator
HYD28_RS05595	ENOG4105BZU	Histidine kinase
HYD28_RS05600	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS05610	ENOG4105C5I	Dehydrogenase
HYD28_RS05615	ENOG4105W1Y	Transcriptional regulator
HYD28_RS05630	ENOG4105XZD	Fe-S protein
HYD28_RS05650	ENOG4105BZU	Histidine kinase
HYD28_RS05655	ENOG4105EYW	Ion transport protein
HYD28_RS05660	ENOG4105CD5	CoA-binding domain protein
HYD28_RS05685	ENOG4105CSA	Coproporphyrinogen iii oxidase
HYD28_RS05690	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HYD28_RS05700	ENOG4108VIA	integral membrane protein
HYD28_RS05705	ENOG4105II7	pyrroline-5-carboxylate reductase
HYD28_RS05710	ENOG4105DFA	alanine racemase domain protein
HYD28_RS05715	ENOG4105CZX	twitching motility protein
HYD28_RS05720	ENOG4105CZX	twitching motility protein
HYD28_RS05735	ENOG4108UJU	UPF0301 protein
HYD28_RS05740	ENOG4105D7Z	glutathione synthase
HYD28_RS05745	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HYD28_RS05760	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HYD28_RS05770	ENOG4105D1S	lipid A biosynthesis
HYD28_RS05775	ENOG4105DFG	type I secretion outer membrane protein
HYD28_RS05780	ENOG41087AY	ADP-Ribose pyrophosphatase
HYD28_RS05785	ENOG4108SX3	cytoplasmic protein
HYD28_RS05790	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HYD28_RS05795	ENOG4105IPS	esterase
HYD28_RS05800	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HYD28_RS05805	ENOG4105DKB	L-sorbosone dehydrogenase
HYD28_RS05810	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HYD28_RS05815	ENOG4108MA4	Peptidase M66
HYD28_RS05820	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HYD28_RS05825	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
HYD28_RS05830	ENOG4105CPI	Metal Dependent Phosphohydrolase
HYD28_RS05840	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HYD28_RS05845	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HYD28_RS05850	ENOG4105MYG	DNA polymerase iii, chi subunit
HYD28_RS05855	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HYD28_RS05860	ENOG4108M8S	permease YjgP YjgQ family protein
HYD28_RS05865	ENOG4108K5H	permease YjgP YjgQ family protein
HYD28_RS05875	ENOG4105CSU	acyl-Coa dehydrogenase
HYD28_RS05885	ENOG4105BZU	Histidine kinase
HYD28_RS05900	ENOG4105DJ2	Major Facilitator Superfamily
HYD28_RS05930	ENOG4105C26	Dehydrogenase
HYD28_RS05935	ENOG4105EA8	2-Nitropropane dioxygenase
HYD28_RS05955	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS05965	ENOG4105BZU	Histidine kinase
HYD28_RS05980	ENOG41060NJ	transcriptional regulator
HYD28_RS05985	ENOG4105CT4	transporter
HYD28_RS06030	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HYD28_RS06045	ENOG4105CAY	ferredoxin--nadp reductase
HYD28_RS06050	ENOG4105C09	Bile acid
HYD28_RS06055	ENOG4105DMT	epimerase dehydratase
HYD28_RS06075	ENOG4105CPC	Aldo Keto reductase
HYD28_RS06090	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HYD28_RS06095	ENOG4105D22	carbon starvation protein
HYD28_RS06100	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HYD28_RS06105	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS06135	ENOG4105DH7	May be involved in recombination (By similarity)
HYD28_RS06140	ENOG4105BZU	Histidine kinase
HYD28_RS06145	ENOG4107YTP	response regulator receiver protein
HYD28_RS06155	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HYD28_RS06160	ENOG4105D98	threonine synthase
HYD28_RS06175	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HYD28_RS06180	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HYD28_RS06195	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HYD28_RS06200	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HYD28_RS06205	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HYD28_RS06210	ENOG4108ZAI	phosphatidylglycerophosphatase a
HYD28_RS06215	ENOG4105BZU	Histidine kinase
HYD28_RS06220	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HYD28_RS06225	ENOG4105CTB	Polyprenyl synthetase
HYD28_RS06230	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HYD28_RS06235	ENOG4105E14	MotA TolQ exbB proton channel
HYD28_RS06240	ENOG4106VK6	Flagellar motor protein
HYD28_RS06250	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HYD28_RS06255	ENOG4105CH2	amidohydrolase
HYD28_RS06260	ENOG4107QR8	Thioredoxin
HYD28_RS06285	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HYD28_RS06290	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HYD28_RS06295	ENOG4105E0A	ABC, transporter
HYD28_RS06300	ENOG4105EHG	Permease protein
HYD28_RS06305	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HYD28_RS06310	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HYD28_RS06315	ENOG4108YZT	Adenosylcobinamide kinase
HYD28_RS06320	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HYD28_RS06325	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HYD28_RS06330	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HYD28_RS06335	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HYD28_RS06350	ENOG4105D1Q	UPF0246 protein
HYD28_RS06355	ENOG4105D8X	mechanosensitive ion channel
HYD28_RS06360	ENOG4108JQ1	Dehydrogenase
HYD28_RS06365	ENOG4105E66	phosphoriboisomerase A
HYD28_RS06370	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HYD28_RS06390	ENOG4108YZA	Nitrogen regulatory protein pii
HYD28_RS06405	ENOG4105BZ4	penicillin-binding protein
HYD28_RS06410	ENOG4108KPZ	tonB-dependent Receptor
HYD28_RS06420	ENOG4105CXT	aspartate transcarbamylase
HYD28_RS06425	ENOG4108YXA	Membrane
HYD28_RS06440	ENOG4105BZU	Histidine kinase
HYD28_RS06440	ENOG4105BZU	Histidine kinase
HYD28_RS06445	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HYD28_RS06460	ENOG4105EYM	Major Facilitator superfamily
HYD28_RS06475	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HYD28_RS06485	ENOG4105M85	Bola protein
HYD28_RS06490	ENOG4105RKW	reductase (By
HYD28_RS06500	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HYD28_RS06505	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HYD28_RS06510	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HYD28_RS06515	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HYD28_RS06520	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HYD28_RS06525	ENOG4105CJ2	(LipO)protein
HYD28_RS06550	ENOG4105E2S	oxidase) subunit II
HYD28_RS06555	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HYD28_RS06560	ENOG4105CCU	oxidase (Subunit III)
HYD28_RS06565	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HYD28_RS06570	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HYD28_RS06575	ENOG4105DGU	Histone deacetylase
HYD28_RS06585	ENOG4105C5H	ABC transporter
HYD28_RS06590	ENOG4105CVG	Homoserine O-transsuccinylase
HYD28_RS06595	ENOG4105C3R	Methionine synthase
HYD28_RS06600	ENOG4105C3R	Methionine synthase
HYD28_RS06605	ENOG4105BZU	Histidine kinase
HYD28_RS06610	ENOG4105VDW	Csbd family
HYD28_RS06620	ENOG4105CQ7	ATP-dependent helicase
HYD28_RS06630	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HYD28_RS06635	ENOG4105HEI	LysR family (Transcriptional regulator
HYD28_RS06640	ENOG4105F27	Major Facilitator
HYD28_RS06680	ENOG4107PMW	Arabinan endo-1,5-alpha-L-arabinosidase
HYD28_RS06695	ENOG4105D64	Mechanosensitive ion channel
HYD28_RS06700	ENOG41067MG	lrgb family
HYD28_RS06710	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS06715	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HYD28_RS06740	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HYD28_RS06745	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HYD28_RS06750	ENOG4105Y75	tpr repeat protein
HYD28_RS06760	ENOG4108IYU	L-aspartate oxidase
HYD28_RS06765	ENOG4105EMN	RNA polymerase sigma factor
HYD28_RS06775	ENOG4105VQK	sigma E regulatory protein, MucB RseB
HYD28_RS06785	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HYD28_RS06790	ENOG4105C3F	Signal peptidase i
HYD28_RS06795	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HYD28_RS06805	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HYD28_RS06810	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HYD28_RS06825	ENOG4105BZU	Histidine kinase
HYD28_RS06830	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HYD28_RS06835	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HYD28_RS06840	ENOG4105DXN	mazG family
HYD28_RS06845	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HYD28_RS06850	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HYD28_RS06855	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
HYD28_RS06860	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HYD28_RS06865	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HYD28_RS06870	ENOG4105HF0	Membrane
HYD28_RS06875	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HYD28_RS06880	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HYD28_RS06885	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HYD28_RS06920	ENOG4105CPQ	Dehydrogenase
HYD28_RS06930	ENOG4105EHV	domain protein
HYD28_RS06935	ENOG4105C5Q	Transcriptional regulator
HYD28_RS06960	ENOG4105XZC	flagellar basal body P-ring biosynthesis protein FlgA
HYD28_RS06965	ENOG4107R88	Chemotaxis protein (CheV)
HYD28_RS06970	ENOG4105BZU	Histidine kinase
HYD28_RS06975	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HYD28_RS06980	ENOG4108ZC9	flagellar basal-body rod protein flgc
HYD28_RS06990	ENOG4105BZE	flagellar hook protein, FlgE
HYD28_RS06995	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HYD28_RS07005	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HYD28_RS07010	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HYD28_RS07015	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HYD28_RS07030	ENOG4105I03	Flagellin
HYD28_RS07040	ENOG4105I03	Flagellin
HYD28_RS07055	ENOG4105MQ3	flagellar protein FliS
HYD28_RS07075	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HYD28_RS07085	ENOG4107R6R	udp-galactopyranose mutase
HYD28_RS07095	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
HYD28_RS07100	ENOG4105D2T	synthase
HYD28_RS07130	ENOG4105F0R	Cytidylyltransferase
HYD28_RS07135	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HYD28_RS07150	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HYD28_RS07155	ENOG4105BZU	Histidine kinase
HYD28_RS07165	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HYD28_RS07170	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HYD28_RS07175	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HYD28_RS07185	ENOG4108JIR	Flagellum-specific ATP synthase
HYD28_RS07195	ENOG4105WF4	Flagellar hook-length control protein
HYD28_RS07205	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HYD28_RS07210	ENOG4105DD5	Flagellar motor switch protein
HYD28_RS07215	ENOG4105K0P	flagellar biosynthesis protein
HYD28_RS07220	ENOG4105CN7	Flagellar biosynthetic protein FliP
HYD28_RS07230	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HYD28_RS07235	ENOG4105D00	flagellar biosynthetic protein flhB
HYD28_RS07240	ENOG4105D7B	Flagellar biosynthesis protein flha
HYD28_RS07245	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HYD28_RS07255	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HYD28_RS07260	ENOG4108VYJ	response regulator receiver protein
HYD28_RS07265	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HYD28_RS07275	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HYD28_RS07280	ENOG4105E14	MotA TolQ exbB proton channel
HYD28_RS07285	ENOG4106VK6	Flagellar motor protein
HYD28_RS07290	ENOG4107QJE	Chromosome Partitioning Protein
HYD28_RS07300	ENOG4108V3W	Chemotaxis protein, CheW
HYD28_RS07320	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HYD28_RS07325	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HYD28_RS07330	ENOG41060IM	Heme exporter protein
HYD28_RS07335	ENOG4105X3C	heme exporter protein
HYD28_RS07340	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HYD28_RS07345	ENOG4105DA4	cytochrome c-type biogenesis protein
HYD28_RS07350	ENOG4107QX9	Thiol disulfide interChange protein
HYD28_RS07355	ENOG4108M1T	Cytochrome c-type biogenesis protein
HYD28_RS07365	ENOG410903C	(LipO)protein
HYD28_RS07370	ENOG4105D58	Diguanylate phosphodiesterase
HYD28_RS07375	ENOG4105CK7	Sodium proline symporter
HYD28_RS07380	ENOG4105X2V	dna damage-inducible protein
HYD28_RS07385	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HYD28_RS07395	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HYD28_RS07400	ENOG4105CQC	Prephenate dehydratase
HYD28_RS07405	ENOG4105BZU	Histidine kinase
HYD28_RS07410	ENOG4108ZJT	translation initiation factor, Sui1
HYD28_RS07430	ENOG4105CGF	Aromatic amino acid aminotransferase
HYD28_RS07455	ENOG4107QVM	von Willebrand factor, type A
HYD28_RS07470	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HYD28_RS07475	ENOG4105CHU	acetyl-coa acetyltransferase
HYD28_RS07480	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS07490	ENOG4105MSB	protein, conserved in bacteria
HYD28_RS07495	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HYD28_RS07520	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HYD28_RS07540	ENOG4108JQM	Insulinase (Peptidase family M16)
HYD28_RS07545	ENOG4108BY2	phosphohistidine phosphatase
HYD28_RS07560	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HYD28_RS07575	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HYD28_RS07580	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HYD28_RS07610	ENOG4108ESY	Metal dependent phosphohydrolase
HYD28_RS07615	ENOG4108ESY	Metal dependent phosphohydrolase
HYD28_RS07615	ENOG4108ESY	Metal dependent phosphohydrolase
HYD28_RS07620	ENOG4108BPE	-transporting atpase
HYD28_RS07630	ENOG4105MH2	YfcL protein
HYD28_RS07635	ENOG4105CFC	Transporter
HYD28_RS07640	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS07645	ENOG41090BQ	Glutaredoxin
HYD28_RS07655	ENOG4108ZNX	Heat shock protein
HYD28_RS07660	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HYD28_RS07675	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HYD28_RS07680	ENOG4105CHV	Transcription elongation factor NusA
HYD28_RS07685	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HYD28_RS07690	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HYD28_RS07695	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HYD28_RS07700	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HYD28_RS07705	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HYD28_RS07720	ENOG4105D65	subunit l
HYD28_RS07725	ENOG4108ZE9	Monovalent cation H antiporter subunit C
HYD28_RS07730	ENOG4107R4Z	monovalent cation h antiporter subunit d
HYD28_RS07735	ENOG4105SC1	monovalent cation H antiporter subunit E
HYD28_RS07740	ENOG4105W4C	monovalent cation H antiporter subunit F
HYD28_RS07745	ENOG4105KJM	monovalent cation h antiporter subunit g
HYD28_RS07750	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HYD28_RS07755	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HYD28_RS07760	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HYD28_RS07770	ENOG4105E96	Colicin v production protein
HYD28_RS07775	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HYD28_RS07785	ENOG4105D64	Mechanosensitive ion channel
HYD28_RS07790	ENOG4107ZSV	Receptor
HYD28_RS07810	ENOG4105R8A	Heat shock protein
HYD28_RS07815	ENOG4108Z5K	methylglyoxal synthase
HYD28_RS07820	ENOG4105N14	lysine exporter protein LysE YggA
HYD28_RS07845	ENOG4105DR5	peptidase
HYD28_RS07850	ENOG4105ERH	Fumarylacetoacetate hydrolase
HYD28_RS07865	ENOG4105DUX	Transporter
HYD28_RS07870	ENOG4105EJG	cellulose synthase
HYD28_RS07875	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
HYD28_RS07880	ENOG4107EEX	Cellulose synthase regulator protein
HYD28_RS07885	ENOG4107QZ7	Cellulose synthase catalytic subunit
HYD28_RS07905	ENOG4105D1V	cellulose synthase operon protein YhjU
HYD28_RS07970	ENOG4105EIF	outer membrane protein W
HYD28_RS07975	ENOG4105UQX	Mate efflux family protein
HYD28_RS07980	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HYD28_RS07990	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HYD28_RS08010	ENOG4107YTP	response regulator receiver protein
HYD28_RS08015	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HYD28_RS08020	ENOG4105CJR	Integral membrane protein (MviN
HYD28_RS08025	ENOG4105DTN	riboflavin biosynthesis protein ribF
HYD28_RS08030	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HYD28_RS08035	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HYD28_RS08040	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HYD28_RS08045	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HYD28_RS08055	ENOG4108NEV	two component transcriptional regulator, LytTR family
HYD28_RS08100	ENOG4108YZA	Nitrogen regulatory protein pii
HYD28_RS08105	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYD28_RS08110	ENOG4105C34	Pseudouridine synthase
HYD28_RS08115	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HYD28_RS08120	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HYD28_RS08125	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HYD28_RS08130	ENOG4105D9M	gamma-glutamylcysteine synthetase
HYD28_RS08140	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HYD28_RS08145	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HYD28_RS08155	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYD28_RS08160	ENOG4105RH4	Glycine cleavage system transcriptional repressor
HYD28_RS08165	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HYD28_RS08170	ENOG4105DWD	nucleoside recognition domain protein
HYD28_RS08180	ENOG41061N2	exported protein
HYD28_RS08185	ENOG4105E3I	toluene tolerance
HYD28_RS08200	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HYD28_RS08205	ENOG4105K89	arsenate reductase
HYD28_RS08210	ENOG4105ERG	peptidase m48, ste24p
HYD28_RS08225	ENOG4105C3J	Cysteine desulfurase
HYD28_RS08230	ENOG4105ETE	Transcriptional regulator (LacI family
HYD28_RS08235	ENOG4107QP8	phosphohexose isomerase
HYD28_RS08240	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HYD28_RS08245	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HYD28_RS08270	ENOG4105D44	asparaginase
HYD28_RS08275	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HYD28_RS08285	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HYD28_RS08315	ENOG4105DR9	pseudouridine synthase
HYD28_RS08325	ENOG4105QDK	Flavodoxin
HYD28_RS08330	ENOG4108RWN	rrna methyltransferase
HYD28_RS08335	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HYD28_RS08340	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HYD28_RS08345	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HYD28_RS08365	ENOG4105E0X	reductase
HYD28_RS08370	ENOG4105BZU	Histidine kinase
HYD28_RS08385	ENOG4108VYJ	response regulator receiver protein
HYD28_RS08470	ENOG4105CJ1	ABC, transporter
HYD28_RS08475	ENOG4107QWP	ABC-2 type transporter
HYD28_RS08485	ENOG4105BZU	Histidine kinase
HYD28_RS08490	ENOG4108UYE	Lactoylglutathione lyase
HYD28_RS08495	ENOG4105CXN	decarboxylase
HYD28_RS08510	ENOG4105BZU	Histidine kinase
HYD28_RS08515	ENOG4105CSM	endonuclease III
HYD28_RS08520	ENOG4105DZB	Electron transport complex
HYD28_RS08525	ENOG4108UQQ	Electron transport complex
HYD28_RS08530	ENOG4105D6A	Electron transport complex
HYD28_RS08535	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HYD28_RS08540	ENOG4108R3D	Electron transport complex
HYD28_RS08545	ENOG4105DGN	Electron transport complex
HYD28_RS08550	ENOG4105BZU	Histidine kinase
HYD28_RS08580	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HYD28_RS08585	ENOG4105DR4	Methyltransferase
HYD28_RS08605	ENOG4106428	Protein of unknown function (DUF2496)
HYD28_RS08615	ENOG4105DGU	Histone deacetylase
HYD28_RS08625	ENOG4105EJ9	Membrane
HYD28_RS08630	ENOG4105DVT	helicase
HYD28_RS08635	ENOG4107RDJ	Sulfotransferase
HYD28_RS08640	ENOG4105CQ2	DNA polymerase
HYD28_RS08645	ENOG4105D05	Receptor
HYD28_RS08670	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HYD28_RS08685	ENOG4105BZU	Histidine kinase
HYD28_RS08695	ENOG4105CFI	type iii restriction protein res subunit
HYD28_RS08705	ENOG4105CFU	surface antigen
HYD28_RS08720	ENOG4105CQ7	ATP-dependent helicase
HYD28_RS08735	ENOG4105DR4	Methyltransferase
HYD28_RS08740	ENOG4105EST	Metal Dependent Phosphohydrolase
HYD28_RS08750	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS08755	ENOG4105BZU	Histidine kinase
HYD28_RS08810	ENOG4105C6T	cysteine synthase
HYD28_RS08825	ENOG4105WH1	Two component transcriptional regulator luxr family
HYD28_RS08830	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HYD28_RS08885	ENOG4105BZG	amino acid carrier protein
HYD28_RS08910	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
HYD28_RS08915	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HYD28_RS08925	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HYD28_RS08945	ENOG4105BZG	amino acid carrier protein
HYD28_RS08955	ENOG4105VUT	cytoplasmic protein
HYD28_RS08965	ENOG4105F3T	(LipO)protein
HYD28_RS08970	ENOG4108JUA	Transcriptional regulator
HYD28_RS08995	ENOG4105DSF	transport protein
HYD28_RS09005	ENOG4105IFJ	Histidine kinase
HYD28_RS09010	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HYD28_RS09020	ENOG4105K9H	YciI-like protein
HYD28_RS09025	ENOG4105C8J	)-transporter
HYD28_RS09035	ENOG4107835	probably involved in intracellular septation (By similarity)
HYD28_RS09040	ENOG4105K70	DNA-binding protein
HYD28_RS09045	ENOG4108Z0Z	intracellular protease Pfpi family
HYD28_RS09050	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HYD28_RS09055	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HYD28_RS09060	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HYD28_RS09065	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HYD28_RS09070	ENOG4105DDQ	anthranilate synthase
HYD28_RS09075	ENOG4105CRQ	synthase (Component I)
HYD28_RS09080	ENOG4105DB7	PHP domain protein
HYD28_RS09085	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HYD28_RS09110	ENOG4105DS1	cytochrome b561
HYD28_RS09145	ENOG4107RBR	Receptor
HYD28_RS09170	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
HYD28_RS09190	ENOG4105VZ8	Transcriptional regulator
HYD28_RS09200	ENOG4105C3F	Signal peptidase i
HYD28_RS09210	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HYD28_RS09215	ENOG4105D1F	ATP-binding protein
HYD28_RS09235	ENOG4105DHP	deoxycytidine triphosphate deaminase
HYD28_RS09260	ENOG4105CHM	Aminotransferase
HYD28_RS09265	ENOG4107MBR	17 kDa surface antigen
HYD28_RS09295	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HYD28_RS09300	ENOG4105KUZ	arsenate reductase
HYD28_RS09315	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HYD28_RS09320	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HYD28_RS09325	ENOG4105PQ6	UPF0208 membrane protein
HYD28_RS09330	ENOG4105DHI	Methyltransferase
HYD28_RS09340	ENOG4105CGK	Exodeoxyribonuclease III
HYD28_RS09355	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HYD28_RS09360	ENOG4105FE9	pseudouridine synthase
HYD28_RS09365	ENOG4105DCF	alanine dehydrogenase
HYD28_RS09370	ENOG4105EW9	transcriptional regulator AsnC family
HYD28_RS09375	ENOG4105CNU	cell division protein FtsK
HYD28_RS09380	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HYD28_RS09385	ENOG4105D1H	recombination factor protein RarA
HYD28_RS09390	ENOG4105WMR	Protein CrcB homolog
HYD28_RS09395	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HYD28_RS09405	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HYD28_RS09410	ENOG4105C4X	radical SAM domain protein
HYD28_RS09420	ENOG4108UJV	acyl-CoA thioesterase i
HYD28_RS09425	ENOG4108I0Y	(ABC) transporter
HYD28_RS09430	ENOG4105CV6	ABC transporter, permease
HYD28_RS09435	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HYD28_RS09440	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HYD28_RS09445	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HYD28_RS09450	ENOG4105E02	MotA TolQ exbB proton channel
HYD28_RS09455	ENOG4105M8F	Biopolymer transport protein exbD tolR
HYD28_RS09465	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HYD28_RS09470	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HYD28_RS09475	ENOG4105UFD	tol-pal system protein YbgF
HYD28_RS09520	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HYD28_RS09545	ENOG4105CF7	AraC family transcriptional regulator
HYD28_RS09560	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HYD28_RS09580	ENOG4105DSY	exodeoxyribonuclease V, gamma
HYD28_RS09585	ENOG4107QKA	exodeoxyribonuclease V beta
HYD28_RS09590	ENOG4107QYX	exodeoxyribonuclease v alpha
HYD28_RS09600	ENOG4105EN6	Membrane
HYD28_RS09610	ENOG4108W63	CRP FNR family transcriptional regulator
HYD28_RS09625	ENOG4108IXY	short-chain dehydrogenase reductase
HYD28_RS09630	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HYD28_RS09645	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HYD28_RS09660	ENOG4105CSR	polyphosphate kinase 2
HYD28_RS09675	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HYD28_RS09680	ENOG4105Q9Y	Universal stress protein
HYD28_RS09685	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HYD28_RS09710	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HYD28_RS09725	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HYD28_RS09755	ENOG4108JA2	transcriptioN-repair coupling factor
HYD28_RS09780	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HYD28_RS09795	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HYD28_RS09800	ENOG4109015	Biopolymer transport protein exbD tolR
HYD28_RS09835	ENOG4105EKQ	RNA-directed DNA polymerase
HYD28_RS09850	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
HYD28_RS09860	ENOG4105E68	Sulfatase
HYD28_RS09865	ENOG4105YDX	UPF0352 protein
HYD28_RS09870	ENOG4106V8H	Nucleoid-associated protein
HYD28_RS09885	ENOG41082W1	Cupin 2, conserved barrel domain protein
HYD28_RS09890	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HYD28_RS09895	ENOG4105C03	ribonuclease
HYD28_RS09900	ENOG4105EI2	Pseudouridine synthase
HYD28_RS09905	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HYD28_RS09910	ENOG4108UHJ	MAF-like protein
HYD28_RS09915	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HYD28_RS09920	ENOG4105VGS	50s ribosomal protein l32
HYD28_RS09925	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HYD28_RS09930	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HYD28_RS09935	ENOG4105CHR	reductase
HYD28_RS09940	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HYD28_RS09945	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HYD28_RS09950	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HYD28_RS09955	ENOG4105HHA	aminodeoxychorismate lyase
HYD28_RS09960	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HYD28_RS09965	ENOG4107QRG	dna polymerase iii
HYD28_RS09975	ENOG4105F8V	Hydrolase, tatD family
HYD28_RS09990	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HYD28_RS10000	ENOG4105CR4	methylisocitrate lyase
HYD28_RS10005	ENOG4105BZN	citrate synthase
HYD28_RS10010	ENOG4108I0Z	Aconitate hydratase
HYD28_RS10015	ENOG4105C7F	AcnD-accessory protein PrpF
HYD28_RS10055	ENOG4108R6K	riboflavin synthase, subunit alpha
HYD28_RS10085	ENOG4105CD3	dihydroorotase
HYD28_RS10095	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HYD28_RS10115	ENOG4105BZ1	(ABC) transporter
HYD28_RS10135	ENOG4105BZU	Histidine kinase
HYD28_RS10145	ENOG4105EB3	Histidine kinase
HYD28_RS10160	ENOG4105D82	Glutamate dehydrogenase
HYD28_RS10170	ENOG4105CEY	Amp-dependent synthetase and ligase
HYD28_RS10185	ENOG4105C22	threonyL-tRNA synthetase
HYD28_RS10190	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HYD28_RS10195	ENOG41082NX	50s ribosomal protein l35
HYD28_RS10200	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HYD28_RS10210	ENOG4105C5X	domain protein
HYD28_RS10215	ENOG4108XM1	transcriptional regulator AsnC family
HYD28_RS10220	ENOG4105CHH	sulfate transporter
HYD28_RS10225	ENOG4108HRK	Histidine kinase
HYD28_RS10230	ENOG4108NEV	two component transcriptional regulator, LytTR family
HYD28_RS10235	ENOG4105CA9	Pyruvate kinase
HYD28_RS10240	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HYD28_RS10245	ENOG4105HDK	L-asparaginase
HYD28_RS10250	ENOG4105D07	Signal peptide peptidase, SppA
HYD28_RS10255	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HYD28_RS10265	ENOG41069NU	Nitroreductase
HYD28_RS10285	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HYD28_RS10290	ENOG41090R7	Ferric uptake
HYD28_RS10295	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HYD28_RS10300	ENOG4105NNH	LexA regulated protein
HYD28_RS10310	ENOG4105EV9	Alpha Beta Hydrolase
HYD28_RS10315	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HYD28_RS10320	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HYD28_RS10325	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
HYD28_RS10330	ENOG4107R0V	Pyruvate dehydrogenase
HYD28_RS10335	ENOG4105CPP	Dehydrogenase, E1 component
HYD28_RS10360	ENOG4108IUW	ABC transporter
HYD28_RS10365	ENOG4108SDH	ABC, transporter
HYD28_RS10370	ENOG4105BZU	Histidine kinase
HYD28_RS10380	ENOG41080BH	prolyl-tRNA synthetase
HYD28_RS10385	ENOG4108R96	Methyltransferase, YaeB family
HYD28_RS10400	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HYD28_RS10405	ENOG4105BZJ	Electron transfer flavoprotein
HYD28_RS10410	ENOG4105C10	Electron transfer flavoprotein
HYD28_RS10420	ENOG4105C5S	asparaginyl-tRNA synthetase
HYD28_RS10435	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HYD28_RS10440	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HYD28_RS10445	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HYD28_RS10450	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HYD28_RS10455	ENOG4105D0M	Protease HtpX homolog
HYD28_RS10480	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
HYD28_RS10490	ENOG4105XEA	Tetr family transcriptional regulator
HYD28_RS10495	ENOG4105C5H	ABC transporter
HYD28_RS10500	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HYD28_RS10505	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HYD28_RS10515	ENOG4105HMI	Membrane
HYD28_RS10540	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HYD28_RS10545	ENOG4107R1I	NAD-dependent malic enzyme
HYD28_RS10605	ENOG4105C5H	ABC transporter
HYD28_RS10615	ENOG4107YTP	response regulator receiver protein
HYD28_RS10630	ENOG4105F8C	transglutaminase domain-containing protein
HYD28_RS10635	ENOG4105D3Y	Na H antiporter
HYD28_RS10645	ENOG4105CHW	UPF0052 protein
HYD28_RS10660	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS10695	ENOG4105CPK	Glycosyl transferase (Group 1
HYD28_RS10710	ENOG4108UW5	maltose o-acetyltransferase
HYD28_RS10725	ENOG4107T8Q	Glycosyl transferase (Group 1
HYD28_RS10735	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS10755	ENOG4105DR5	peptidase
HYD28_RS10765	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HYD28_RS10770	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
HYD28_RS10775	ENOG4108WUH	Transcriptional regulator, TetR family
HYD28_RS10780	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HYD28_RS10785	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HYD28_RS10790	ENOG4107XDR	Lactoylglutathione lyase
HYD28_RS10810	ENOG4105CHR	reductase
HYD28_RS10815	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HYD28_RS10820	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS10825	ENOG4105E39	Enoyl-CoA hydratase
HYD28_RS10835	ENOG4105C26	Dehydrogenase
HYD28_RS10840	ENOG4105CHU	acetyl-coa acetyltransferase
HYD28_RS10855	ENOG4107QX3	carboxylase
HYD28_RS10860	ENOG4108M7F	enoyl-CoA hydratase isomerase
HYD28_RS10870	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HYD28_RS10875	ENOG4107QP7	CoA-transferase subunit A
HYD28_RS10885	ENOG4105ETT	transcriptional Regulator, LysR family
HYD28_RS10915	ENOG4108M3R	transcriptional activator CadC
HYD28_RS10930	ENOG4105E0X	reductase
HYD28_RS10935	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HYD28_RS10940	ENOG4105P4J	Allophanate hydrolase, subunit 1
HYD28_RS10945	ENOG4107R7A	Allophanate hydrolase subunit 2
HYD28_RS10950	ENOG4105CAQ	asparagine synthetase
HYD28_RS10955	ENOG4105C94	Transporter
HYD28_RS10960	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HYD28_RS10985	ENOG4105C72	UPF0176 protein
HYD28_RS10990	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS11000	ENOG4105EKQ	RNA-directed DNA polymerase
HYD28_RS11015	ENOG4105CFV	Tetratricopeptide repeat protein
HYD28_RS11025	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HYD28_RS11030	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HYD28_RS11035	ENOG4105CAT	Cytidine monophosphate kinase
HYD28_RS11040	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HYD28_RS11045	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HYD28_RS11050	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HYD28_RS11055	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HYD28_RS11060	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HYD28_RS11065	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HYD28_RS11070	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HYD28_RS11075	ENOG4105XPH	Ferredoxin
HYD28_RS11085	ENOG4105UGU	tonB-dependent Receptor
HYD28_RS11090	ENOG4105CX6	glutaminyL-tRNA synthetase
HYD28_RS11100	ENOG4108DQ3	n-acetylglutamate synthase
HYD28_RS11105	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HYD28_RS11110	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HYD28_RS11115	ENOG4105C7S	Dehydrogenase
HYD28_RS11120	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HYD28_RS11125	ENOG4105E33	succinate dehydrogenase
HYD28_RS11130	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HYD28_RS11135	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HYD28_RS11140	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HYD28_RS11145	ENOG4105BZN	citrate synthase
HYD28_RS11150	ENOG4105C9B	Cysteine desulfurase
HYD28_RS11155	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HYD28_RS11160	ENOG4105CUZ	uba thif-type nad fad binding protein
HYD28_RS11165	ENOG4108W1A	pseudouridine synthase
HYD28_RS11170	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HYD28_RS11175	ENOG4105W49	UPF0434 protein
HYD28_RS11180	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HYD28_RS11185	ENOG4105BZ1	(ABC) transporter
HYD28_RS11190	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HYD28_RS11205	ENOG4105C5H	ABC transporter
HYD28_RS11215	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HYD28_RS11220	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HYD28_RS11225	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HYD28_RS11230	ENOG4105C7I	Dehydrogenase
HYD28_RS11245	ENOG4105D25	secreted protein
HYD28_RS11260	ENOG4105CD8	aminopeptidase N
HYD28_RS11265	ENOG4105DFD	Na H antiporter
HYD28_RS11270	ENOG4105CN1	protease
HYD28_RS11275	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HYD28_RS11285	ENOG4108ZGC	gaf domain protein
HYD28_RS11305	ENOG4108MN8	Membrane
HYD28_RS11315	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HYD28_RS11320	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HYD28_RS11325	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HYD28_RS11330	ENOG4108R99	pseudouridine synthase
HYD28_RS11340	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HYD28_RS11345	ENOG41075W9	High frequency lysogenization protein HflD homolog
HYD28_RS11355	ENOG4105EZE	Cupin 4 family protein
HYD28_RS11375	ENOG4105D60	lipoprotein releasing system transmembrane protein
HYD28_RS11380	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HYD28_RS11385	ENOG4105D60	lipoprotein releasing system transmembrane protein
HYD28_RS11390	ENOG4105CC0	LysR family Transcriptional regulator
HYD28_RS11415	ENOG4105C94	Transporter
HYD28_RS11420	ENOG4105KT7	mgtC SapB transporter
HYD28_RS11430	ENOG4107RX2	synthase
HYD28_RS11435	ENOG4105ECQ	AraC Family Transcriptional Regulator
HYD28_RS11455	ENOG4105KT7	mgtC SapB transporter
HYD28_RS11465	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HYD28_RS11470	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HYD28_RS11475	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HYD28_RS11480	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HYD28_RS11490	ENOG4105DQ4	alcohol dehydrogenase
HYD28_RS11495	ENOG4108JJ7	ABC transporter
HYD28_RS11500	ENOG4105CDY	transcriptional regulatory protein
HYD28_RS11520	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HYD28_RS11525	ENOG4108UHU	Aldolase
HYD28_RS11530	ENOG4105C01	Dihydroxy-acid dehydratase
HYD28_RS11535	ENOG4107KJX	Transcriptional regulator
HYD28_RS11540	ENOG4105CHC	glucokinase (EC 2.7.1.2)
HYD28_RS11545	ENOG4105ETE	Transcriptional regulator (LacI family
HYD28_RS11550	ENOG4105DDY	UPF0142 protein ycaO
HYD28_RS11580	ENOG4108IUK	alpha amylase, catalytic
HYD28_RS11595	ENOG4105CG3	alpha amylase, catalytic region
HYD28_RS11600	ENOG4108TEB	UPF0114 protein
HYD28_RS11615	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HYD28_RS11620	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HYD28_RS11635	ENOG4105ERU	peptidase
HYD28_RS11640	ENOG4108M0H	Extracellular lipase
HYD28_RS11645	ENOG4105UBK	short-chain dehydrogenase reductase
HYD28_RS11650	ENOG4105JIM	Phosphatidylserine synthase
HYD28_RS11655	ENOG4105C3M	thioredoxin reductase
HYD28_RS11660	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HYD28_RS11665	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HYD28_RS11675	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HYD28_RS11680	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HYD28_RS11685	ENOG4105VEQ	Cold shock protein
HYD28_RS11695	ENOG4105BZU	Histidine kinase
HYD28_RS11710	ENOG4105BZU	Histidine kinase
HYD28_RS11715	ENOG4105ECP	epimerase
HYD28_RS11870	ENOG4105ED4	portal protein
HYD28_RS11895	ENOG4105BZU	Histidine kinase
HYD28_RS11930	ENOG4105RDA	repressor
HYD28_RS11950	ENOG4105KT5	UmuD protein
HYD28_RS11965	ENOG4105DFP	Integrase
HYD28_RS11970	ENOG4105CJB	Exodeoxyribonuclease I
HYD28_RS11975	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HYD28_RS11980	ENOG4108V06	Glutathione peroxidase
HYD28_RS11985	ENOG4105C5I	Dehydrogenase
HYD28_RS11990	ENOG4105C8J	)-transporter
HYD28_RS12000	ENOG4105CFH	Aspartokinase
HYD28_RS12005	ENOG4105DN9	Na H antiporter
HYD28_RS12035	ENOG4105KRS	Proteinase inhibitor
HYD28_RS12040	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HYD28_RS12065	ENOG4105FQP	Beta-lactamase
HYD28_RS12070	ENOG4105EJC	lysr family transcriptional regulator
HYD28_RS12075	ENOG4108RCM	Nitroreductase
HYD28_RS12090	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HYD28_RS12095	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HYD28_RS12100	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HYD28_RS12115	ENOG4105ERG	peptidase m48, ste24p
HYD28_RS12120	ENOG4105C2C	drug resistance transporter, Bcr CflA
HYD28_RS12125	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYD28_RS12130	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HYD28_RS12135	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HYD28_RS12145	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HYD28_RS12165	ENOG4105EB3	Histidine kinase
HYD28_RS12175	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HYD28_RS12185	ENOG4105BZ8	glutamate synthase
HYD28_RS12190	ENOG4105CBC	glutamate synthase
HYD28_RS12200	ENOG4105C19	ABC transporter
HYD28_RS12205	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HYD28_RS12210	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HYD28_RS12215	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS12220	ENOG4105BZU	Histidine kinase
HYD28_RS12225	ENOG4105M2J	Glutaredoxin
HYD28_RS12230	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HYD28_RS12235	ENOG4105CYN	Serine protein kinase
HYD28_RS12245	ENOG4105ED1	spovr family
HYD28_RS12250	ENOG4105Q9Y	Universal stress protein
HYD28_RS12255	ENOG4106KTS	Inner membrane protein yeaI
HYD28_RS12260	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HYD28_RS12265	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HYD28_RS12270	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HYD28_RS12275	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HYD28_RS12280	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HYD28_RS12285	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HYD28_RS12290	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HYD28_RS12295	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HYD28_RS12305	ENOG4105E18	UPF0276 protein
HYD28_RS12315	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HYD28_RS12335	ENOG410822N	TonB family
HYD28_RS12340	ENOG4109015	Biopolymer transport protein exbD tolR
HYD28_RS12360	ENOG4108Q9V	regulatoR
HYD28_RS12365	ENOG4105VEQ	Cold shock protein
HYD28_RS12370	ENOG4105EKE	dihydroorotase
HYD28_RS12375	ENOG4105BZU	Histidine kinase
HYD28_RS12380	ENOG4107QPN	acyl-Coa dehydrogenase
HYD28_RS12395	ENOG4105KWG	Pfam:DUF1696
HYD28_RS12400	ENOG4105CJ1	ABC, transporter
HYD28_RS12410	ENOG4105C28	cystathionine
HYD28_RS12415	ENOG4105E09	nadh pyrophosphatase
HYD28_RS12420	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HYD28_RS12430	ENOG4105CE4	GlcNAc 6-P deacetylase
HYD28_RS12435	ENOG4105RD7	BadF BadG BcrA BcrD
HYD28_RS12455	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS12490	ENOG4105C9M	aspartyl-trna synthetase
HYD28_RS12495	ENOG41081XQ	Conserved Protein
HYD28_RS12500	ENOG4108VKG	metal-dependent hydrolase
HYD28_RS12515	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HYD28_RS12520	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HYD28_RS12525	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HYD28_RS12530	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HYD28_RS12540	ENOG4105E7A	Glutamine amidotransferase
HYD28_RS12545	ENOG4107QPN	acyl-Coa dehydrogenase
HYD28_RS12575	ENOG4105DZ2	Transcriptional regulator
HYD28_RS12580	ENOG4107S90	membrAne
HYD28_RS12585	ENOG4107QNR	UPF0135 protein
HYD28_RS12605	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HYD28_RS12615	ENOG4106TD9	Diguanylate cyclase
HYD28_RS12625	ENOG4107RDP	Dehydrogenase
HYD28_RS12640	ENOG4105P8F	nudix hydrolase
HYD28_RS12645	ENOG4105EJQ	L-serine dehydratase
HYD28_RS12650	ENOG4107R11	Transcriptional regulator
HYD28_RS12660	ENOG4105C7N	Xanthine uracil vitamin C permease
HYD28_RS12715	ENOG4107RZZ	dna polymerase iii epsilon subunit
HYD28_RS12720	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HYD28_RS12730	ENOG4105D1A	Methyltransferase
HYD28_RS12735	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HYD28_RS12740	ENOG4105E9H	Lytic Murein transglycosylase
HYD28_RS12750	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HYD28_RS12765	ENOG4105EXN	Sulfate transport protein CysZ
HYD28_RS12770	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
HYD28_RS12775	ENOG4105M08	Membrane
HYD28_RS12785	ENOG4105ETT	transcriptional Regulator, LysR family
HYD28_RS12790	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HYD28_RS12810	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS12815	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HYD28_RS12820	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HYD28_RS12825	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HYD28_RS12830	ENOG4108986	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HYD28_RS12835	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HYD28_RS12840	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HYD28_RS12845	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HYD28_RS12850	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HYD28_RS12855	ENOG4105C3G	gtp-binding protein
HYD28_RS12910	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HYD28_RS12920	ENOG4105C9A	Phoh family
HYD28_RS12925	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HYD28_RS12930	ENOG4108JU5	Magnesium and cobalt efflux protein
HYD28_RS12935	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HYD28_RS12940	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HYD28_RS12945	ENOG4105DAN	ATP-dependent protease
HYD28_RS12955	ENOG4105C8T	Leucyl-tRNA synthetase
HYD28_RS12970	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HYD28_RS12975	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HYD28_RS12980	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HYD28_RS12985	ENOG4105CJN	penicillin-binding protein
HYD28_RS12990	ENOG4105CNI	cell division protein FtsW
HYD28_RS12995	ENOG4105K6T	rare lipoprotein A
HYD28_RS13000	ENOG4105DZ1	carboxypeptidase
HYD28_RS13010	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HYD28_RS13015	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HYD28_RS13040	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HYD28_RS13045	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HYD28_RS13050	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HYD28_RS13065	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS13075	ENOG4105E39	Enoyl-CoA hydratase
HYD28_RS13110	ENOG4105EIY	sodium-type flagellar protein motY
HYD28_RS13120	ENOG4105E0U	tyrosine-specific transport protein
HYD28_RS13125	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HYD28_RS13140	ENOG4107ZSV	Receptor
HYD28_RS13145	ENOG4105WH1	Two component transcriptional regulator luxr family
HYD28_RS13170	ENOG4105NTZ	Preprotein translocase subunit SecG
HYD28_RS13175	ENOG4105CP7	Triose-phosphate isomerase
HYD28_RS13180	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HYD28_RS13185	ENOG4105EEI	dihydropteroate synthase
HYD28_RS13190	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HYD28_RS13195	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HYD28_RS13200	ENOG4105HBR	Rna-binding protein
HYD28_RS13215	ENOG4105GNX	MltA-interacting MipA family protein
HYD28_RS13225	ENOG4107EXC	regulatoR
HYD28_RS13230	ENOG4105E0F	Histidine kinase
HYD28_RS13235	ENOG4105C8J	)-transporter
HYD28_RS13240	ENOG4107YB6	acetyltransferase, (GNAT) family
HYD28_RS13245	ENOG4108N23	SpoOM-related protein
HYD28_RS13250	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HYD28_RS13265	ENOG4105JJR	Histidine kinase
HYD28_RS13270	ENOG4107EXC	regulatoR
HYD28_RS13285	ENOG4105BZU	Histidine kinase
HYD28_RS13290	ENOG4105EMY	transcriptional regulator
HYD28_RS13295	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HYD28_RS13315	ENOG41082IR	Excinuclease ABC C subunit domain protein
HYD28_RS13320	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HYD28_RS13325	ENOG4105VDB	UPF0125 protein
HYD28_RS13330	ENOG4108Z1B	Cyclase dehydrase
HYD28_RS13335	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HYD28_RS13340	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HYD28_RS13345	ENOG4105D3R	alkyl hydroperoxide reductase
HYD28_RS13355	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HYD28_RS13365	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HYD28_RS13370	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HYD28_RS13375	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HYD28_RS13380	ENOG4105K5M	30s ribosomal protein S16
HYD28_RS13385	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYD28_RS13390	ENOG4106KVJ	cytochrome C assembly protein
HYD28_RS13395	ENOG4108JU6	CBS domain protein
HYD28_RS13405	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HYD28_RS13415	ENOG4105GR3	Histidine kinase
HYD28_RS13420	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HYD28_RS13425	ENOG4105E0M	Sulfatase
HYD28_RS13430	ENOG4105DIJ	Phosphoethanolamine transferase
HYD28_RS13435	ENOG41080IJ	Diacylglycerol kinase
HYD28_RS13450	ENOG4105F32	YngK protein
HYD28_RS13475	ENOG4105BZU	Histidine kinase
HYD28_RS13530	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HYD28_RS13535	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HYD28_RS13540	ENOG4105C0B	DNA polymerase III (alpha subunit)
HYD28_RS13545	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HYD28_RS13550	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HYD28_RS13555	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HYD28_RS13560	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HYD28_RS13570	ENOG4108JJ9	ABC, transporter
HYD28_RS13575	ENOG4108JJ8	(ABC) transporter
HYD28_RS13590	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HYD28_RS13595	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HYD28_RS13605	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYD28_RS13610	ENOG4105DZP	Membrane-associated zinc metalloprotease
HYD28_RS13615	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HYD28_RS13620	ENOG4105KNE	Phosphatidate cytidylyltransferase
HYD28_RS13625	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HYD28_RS13630	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HYD28_RS13635	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HYD28_RS13640	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HYD28_RS13645	ENOG4105CE9	30S ribosomal protein S2
HYD28_RS13650	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HYD28_RS13655	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HYD28_RS13660	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HYD28_RS13685	ENOG41090A4	Pterin carbinolamine dehydratase
HYD28_RS13690	ENOG4105MIR	Phenylalanine 4-monooxygenase
HYD28_RS13695	ENOG4105C28	cystathionine
HYD28_RS13705	ENOG4105CM6	amino acid regulated cytosolic protein
HYD28_RS13710	ENOG4105FM1	phage shock protein C
HYD28_RS13720	ENOG41087YS	Phage shock protein A
HYD28_RS13725	ENOG4105E51	psp operon transcriptional activator
HYD28_RS13730	ENOG4105DEF	Extracellular solute-binding protein, family 5
HYD28_RS13735	ENOG4108EKA	peptide transport system, permease
HYD28_RS13740	ENOG4108EU3	peptide transport system, permease
HYD28_RS13745	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HYD28_RS13750	ENOG4108JQ2	peptide transport system atp-binding protein
HYD28_RS13765	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HYD28_RS13770	ENOG4105K70	DNA-binding protein
HYD28_RS13775	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HYD28_RS13780	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HYD28_RS13785	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HYD28_RS13790	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HYD28_RS13820	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HYD28_RS13830	ENOG4105C8N	cysteinyl-tRNA synthetase
HYD28_RS13835	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HYD28_RS13850	ENOG4105BZU	Histidine kinase
HYD28_RS13905	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HYD28_RS13925	ENOG4105EGS	Mechanosensitive ion channel
HYD28_RS13935	ENOG4105DGW	oligopeptidase A
HYD28_RS13940	ENOG4105EMK	carboxylate amino acid amine transporter
HYD28_RS13955	ENOG4105CR8	Transcriptional regulator
HYD28_RS13960	ENOG4107R7Y	intracellular protease Pfpi family
HYD28_RS13980	ENOG4105CYM	Glutathione S-transferase
HYD28_RS13995	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HYD28_RS14000	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HYD28_RS14010	ENOG4108Z9K	Osmotically inducible protein
HYD28_RS14045	ENOG4105F27	Major Facilitator
HYD28_RS14050	ENOG4105VZ8	Transcriptional regulator
HYD28_RS14060	ENOG4108HMN	Caspase domain
HYD28_RS14090	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HYD28_RS14115	ENOG4105EXG	Transcriptional regulator
HYD28_RS14120	ENOG4105CJW	magnesium transporter
HYD28_RS14135	ENOG4107RNH	Outer membrane receptor FepA
HYD28_RS14145	ENOG4105DAA	L-lactate
HYD28_RS14155	ENOG4105BZU	Histidine kinase
HYD28_RS14165	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HYD28_RS14170	ENOG41066F8	ROK family
HYD28_RS14175	ENOG4105EDR	glucose galactose transporter
HYD28_RS14195	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HYD28_RS14210	ENOG4105BZU	Histidine kinase
HYD28_RS14215	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HYD28_RS14225	ENOG4108SQ4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HYD28_RS14230	ENOG4105E5W	Transporter
HYD28_RS14265	ENOG4105EW9	transcriptional regulator AsnC family
HYD28_RS14280	ENOG4105DS1	cytochrome b561
HYD28_RS14295	ENOG4108IJ8	ABC transporter
HYD28_RS14300	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
HYD28_RS14305	ENOG4107QUT	magnesium and cobalt transport protein CorA
HYD28_RS14310	ENOG4105FQP	Beta-lactamase
HYD28_RS14320	ENOG4105VMP	Transcriptional regulator
HYD28_RS14345	ENOG4105VMP	Transcriptional regulator
HYD28_RS14380	ENOG4105BZU	Histidine kinase
HYD28_RS14395	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HYD28_RS14425	ENOG4105CKI	cobalamin synthesis protein
HYD28_RS14445	ENOG4108I6A	alcohol dehydrogenase
HYD28_RS14460	ENOG4108W2Y	isochorismatase
HYD28_RS14475	ENOG4105CBC	glutamate synthase
HYD28_RS14510	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HYD28_RS14550	ENOG4105R1U	AraC Family Transcriptional Regulator
HYD28_RS14555	ENOG4105CNM	Receptor
HYD28_RS14575	ENOG4105EKQ	RNA-directed DNA polymerase
HYD28_RS14580	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYD28_RS14590	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HYD28_RS14600	ENOG4105DND	Transcriptional regulator
HYD28_RS14615	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HYD28_RS14620	ENOG4105D0A	hydroxylase
HYD28_RS14625	ENOG4107RAQ	aminopeptidase
HYD28_RS14630	ENOG4105E07	UPF0149 protein
HYD28_RS14640	ENOG4105BZS	acriflavin resistance protein
HYD28_RS14650	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HYD28_RS14690	ENOG4105BZU	Histidine kinase
HYD28_RS14695	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HYD28_RS14700	ENOG4105CEN	a g-specific adenine glycosylase
HYD28_RS14705	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HYD28_RS14710	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HYD28_RS14715	ENOG4105BZU	Histidine kinase
HYD28_RS14725	ENOG41065U4	response regulator
HYD28_RS14730	ENOG4105BZU	Histidine kinase
HYD28_RS14735	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HYD28_RS14745	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HYD28_RS14750	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HYD28_RS14755	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HYD28_RS14760	ENOG4105DR5	peptidase
HYD28_RS14770	ENOG4105D9Q	decarboxylase (Beta subunit)
HYD28_RS14775	ENOG4107QSA	Oxaloacetate decarboxylase
HYD28_RS14805	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HYD28_RS14810	ENOG4105CFH	Aspartokinase
HYD28_RS14815	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HYD28_RS14820	ENOG4105Y3E	Modulates RecA activity (By similarity)
HYD28_RS14830	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HYD28_RS14850	ENOG4105WQ5	TonB family
HYD28_RS14865	ENOG4105D8V	Glucose sorbosone dehydrogenase
HYD28_RS14870	ENOG4107S6Z	Na H antiporter
HYD28_RS14880	ENOG4106G6Q	Transcriptional regulator
HYD28_RS14900	ENOG4105EHZ	conserved protein UCP016719
HYD28_RS14905	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYD28_RS14915	ENOG4107RJ1	sodium solute
HYD28_RS14925	ENOG4105DTQ	mandelate racemase muconate lactonizing
HYD28_RS14970	ENOG4105CRK	lysyL-tRNA synthetase
HYD28_RS14980	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HYD28_RS14985	ENOG4105T95	Thiol disulfide interChange protein
HYD28_RS14990	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HYD28_RS14995	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HYD28_RS15010	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HYD28_RS15015	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS15040	ENOG4105EAC	phosphoserine phosphatase
HYD28_RS15050	ENOG4105EYA	deoxyribonuclease
HYD28_RS15055	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HYD28_RS15060	ENOG4105C75	arginyL-tRNA synthetase
HYD28_RS15065	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HYD28_RS15070	ENOG4105BZU	Histidine kinase
HYD28_RS15075	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HYD28_RS15090	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HYD28_RS15095	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HYD28_RS15100	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HYD28_RS15110	ENOG4105D7W	serine acetyltransferase
HYD28_RS15140	ENOG410620I	Diguanylate cyclase
HYD28_RS15145	ENOG4105C1J	atp-dependent rna helicase
HYD28_RS15160	ENOG4107EXC	regulatoR
HYD28_RS15165	ENOG4105E0F	Histidine kinase
HYD28_RS15180	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HYD28_RS15190	ENOG4105BZU	Histidine kinase
HYD28_RS15195	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HYD28_RS15220	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HYD28_RS15225	ENOG4105EB3	Histidine kinase
HYD28_RS15245	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HYD28_RS15255	ENOG4107WP9	Histidine kinase
HYD28_RS15280	ENOG4105EFZ	amidohydrolase
HYD28_RS15300	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HYD28_RS15305	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HYD28_RS15310	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYD28_RS15315	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HYD28_RS15320	ENOG4105DJ0	Poly(A) Polymerase
HYD28_RS15325	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYD28_RS15330	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HYD28_RS15335	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HYD28_RS15345	ENOG4105DJ9	glucan biosynthesis protein
HYD28_RS15350	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HYD28_RS15355	ENOG4105DJH	phosphate
HYD28_RS15360	ENOG4105BZU	Histidine kinase
HYD28_RS15365	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HYD28_RS15375	ENOG4105D2N	Aldolase
HYD28_RS15380	ENOG4105BZA	Phosphoglycerate kinase
HYD28_RS15385	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HYD28_RS15400	ENOG4105C2X	Arabinose 5-phosphate isomerase
HYD28_RS15405	ENOG4107QN1	sodium solute
HYD28_RS15415	ENOG4105BZU	Histidine kinase
HYD28_RS15430	ENOG4105CIY	formyltetrahydrofolate deformylase
HYD28_RS15440	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HYD28_RS15450	ENOG4105CNM	Receptor
HYD28_RS15455	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HYD28_RS15465	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HYD28_RS15480	ENOG4108UM1	dedA family
HYD28_RS15485	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HYD28_RS15490	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HYD28_RS15495	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HYD28_RS15500	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HYD28_RS15505	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HYD28_RS15510	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HYD28_RS15530	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HYD28_RS15545	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HYD28_RS15550	ENOG4105NBK	UPF0345 protein
HYD28_RS15565	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HYD28_RS15570	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HYD28_RS15575	ENOG41080IJ	Diacylglycerol kinase
HYD28_RS15590	ENOG4105I7R	Adenylate cyclase
HYD28_RS15600	ENOG4105EW9	transcriptional regulator AsnC family
HYD28_RS15605	ENOG4105C26	Dehydrogenase
HYD28_RS15610	ENOG4105CPI	Metal Dependent Phosphohydrolase
HYD28_RS15655	ENOG4105BZS	acriflavin resistance protein
HYD28_RS15660	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HYD28_RS15665	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HYD28_RS15675	ENOG4108VPT	UPF0234 protein
HYD28_RS15685	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HYD28_RS15690	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HYD28_RS15695	ENOG41062JF	Transcriptional regulator
HYD28_RS15700	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HYD28_RS15730	ENOG4105CDH	Citrulline--aspartate ligase
HYD28_RS15735	ENOG4105CDH	Citrulline--aspartate ligase
HYD28_RS15750	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HYD28_RS15760	ENOG4105DY8	decarboxylase
HYD28_RS15765	ENOG4105BZU	Histidine kinase
HYD28_RS15770	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HYD28_RS15775	ENOG4105E3A	(ABC) transporter
HYD28_RS15780	ENOG4105DA5	(ABC) transporter
HYD28_RS15785	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HYD28_RS15790	ENOG4105DFU	Cell wall formation (By similarity)
HYD28_RS15795	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HYD28_RS15800	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYD28_RS15805	ENOG4107ZVW	dihydroneopterin aldolase
HYD28_RS15810	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HYD28_RS15815	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HYD28_RS15835	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS15850	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HYD28_RS15855	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HYD28_RS15860	ENOG4105X6C	Flagellar basal body-associated protein FliL
HYD28_RS15865	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
HYD28_RS15870	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HYD28_RS15875	ENOG4105CPQ	Dehydrogenase
HYD28_RS15880	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HYD28_RS15885	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HYD28_RS15890	ENOG4105DKP	glycosyl transferase, family 9
HYD28_RS15895	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HYD28_RS15900	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HYD28_RS15905	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HYD28_RS15915	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HYD28_RS15925	ENOG4105WXT	Conserved Protein
HYD28_RS15930	ENOG410689M	(LipO)protein
HYD28_RS15945	ENOG4108ETH	Formylglycinamide ribotide synthetase
HYD28_RS15950	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HYD28_RS15960	ENOG4108Z6B	deaminase
HYD28_RS15965	ENOG4107RE1	Inosine-guanosine kinase
HYD28_RS15970	ENOG4105CSV	Glutaminase
HYD28_RS15975	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HYD28_RS15980	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HYD28_RS15985	ENOG4105CAK	Cell division ATP-binding protein ftsE
HYD28_RS15990	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HYD28_RS15995	ENOG4106H78	methyltransferase
HYD28_RS16010	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HYD28_RS16015	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HYD28_RS16020	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HYD28_RS16025	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HYD28_RS16030	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HYD28_RS16035	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HYD28_RS16050	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
HYD28_RS16060	ENOG4105BZU	Histidine kinase
HYD28_RS16085	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HYD28_RS16110	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HYD28_RS16125	ENOG4105I08	Pseudouridine synthase
HYD28_RS16130	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS16145	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HYD28_RS16165	ENOG4107RDJ	Sulfotransferase
HYD28_RS16170	ENOG4105KHC	sulfurtransferase
HYD28_RS16180	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
HYD28_RS16200	ENOG4105BZU	Histidine kinase
HYD28_RS16210	ENOG4105C8V	SAICAR synthetase
HYD28_RS16220	ENOG4105C19	ABC transporter
HYD28_RS16250	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HYD28_RS16260	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HYD28_RS16265	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HYD28_RS16270	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HYD28_RS16295	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HYD28_RS16300	ENOG4105C8Q	Methyl-accepting chemotaxis
HYD28_RS16305	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HYD28_RS16310	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HYD28_RS16315	ENOG4105BZU	Histidine kinase
HYD28_RS16320	ENOG4107TCE	N-acetyltransferase
HYD28_RS16330	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HYD28_RS16335	ENOG4108U78	Glutathione S-transferase
HYD28_RS16365	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HYD28_RS16370	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HYD28_RS16375	ENOG4105PAD	Hydrolase
HYD28_RS16380	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HYD28_RS16385	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HYD28_RS16390	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HYD28_RS16395	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HYD28_RS16400	ENOG4105CPF	Cell wall formation (By similarity)
HYD28_RS16405	ENOG4105DFU	Cell wall formation (By similarity)
HYD28_RS16410	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HYD28_RS16415	ENOG4105CNI	cell division protein FtsW
HYD28_RS16420	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HYD28_RS16425	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HYD28_RS16430	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HYD28_RS16435	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HYD28_RS16440	ENOG4105CJN	penicillin-binding protein
HYD28_RS16445	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HYD28_RS16450	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HYD28_RS16455	ENOG4108V6E	Cell division protein mraZ
HYD28_RS16480	ENOG4105CHF	Glutathione S-transferase
HYD28_RS16485	ENOG4105EUB	pirin domain protein
HYD28_RS16490	ENOG4107U9T	Pfam:Ribonuclease_BN
HYD28_RS16500	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HYD28_RS16510	ENOG4105E98	transcriptional regulator DeoR family
HYD28_RS16515	ENOG4105EDR	glucose galactose transporter
HYD28_RS16530	ENOG4105CE4	GlcNAc 6-P deacetylase
HYD28_RS16535	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HYD28_RS16540	ENOG4105E70	isomerase
HYD28_RS16550	ENOG4105EPC	oxidoreductase
HYD28_RS16560	ENOG4105CZH	peptidase
HYD28_RS16570	ENOG4105WH1	Two component transcriptional regulator luxr family
HYD28_RS16580	ENOG4105BZU	Histidine kinase
HYD28_RS16590	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)