locus-tag	class	description
HYD28_RS00015	COG2823	Periplasmic or secreted lipoprotein
HYD28_RS00020	COG2969	positive regulation of protein catabolic process
HYD28_RS00025	COG0625	glutathione transferase activity
HYD28_RS00030	COG2857	Cytochrome c1
HYD28_RS00035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYD28_RS00040	COG0723	plastoquinol--plastocyanin reductase activity
HYD28_RS00050	COG0312	modulator of DNA gyrase
HYD28_RS00065	COG3590	peptidase
HYD28_RS00070	COG0494	nUDIX hydrolase
HYD28_RS00105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYD28_RS00115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYD28_RS00160	COG1086	Polysaccharide biosynthesis protein
HYD28_RS00190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HYD28_RS00195	COG3206	protein involved in exopolysaccharide biosynthesis
HYD28_RS00195	COG0489	protein tyrosine kinase activity
HYD28_RS00200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYD28_RS00205	COG1596	polysaccharide export
HYD28_RS00210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYD28_RS00220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HYD28_RS00225	COG0438	transferase activity, transferring glycosyl groups
HYD28_RS00235	COG1216	Glycosyl transferase, family 2
HYD28_RS00235	COG0463	Glycosyl transferase, family 2
HYD28_RS00250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HYD28_RS00290	COG1450	Type ii and iii secretion system protein
HYD28_RS00335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYD28_RS00355	COG3137	Salt-induced outer membrane protein
HYD28_RS00360	COG0668	transmembrane transport
HYD28_RS00395	COG2378	regulation of single-species biofilm formation
HYD28_RS00445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HYD28_RS00450	COG0316	Belongs to the HesB IscA family
HYD28_RS00455	COG0822	iron-sulfur transferase activity
HYD28_RS00485	COG2199	diguanylate cyclase activity
HYD28_RS00500	COG3659	wide pore channel activity
HYD28_RS00510	COG0246	Mannitol dehydrogenase
HYD28_RS00515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYD28_RS00520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYD28_RS00525	COG1862	Preprotein translocase
HYD28_RS00540	COG5001	Diguanylate cyclase
HYD28_RS00540	COG5002	protein histidine kinase activity
HYD28_RS00565	COG0583	DNA-binding transcription factor activity
HYD28_RS00570	COG0306	phosphate transporter
HYD28_RS00575	COG1392	Phosphate transport regulator
HYD28_RS00590	COG0573	inorganic phosphate transmembrane transporter activity
HYD28_RS00605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HYD28_RS00620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYD28_RS00625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYD28_RS00640	COG2995	paraquat-inducible protein a
HYD28_RS00645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HYD28_RS00655	COG2824	Alkylphosphonate utilization operon protein PhnA
HYD28_RS00665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HYD28_RS00675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HYD28_RS00685	COG0741	lytic transglycosylase activity
HYD28_RS00685	COG1388	LysM domain
HYD28_RS00700	COG3618	amidohydrolase
HYD28_RS00710	COG4948	Mandelate Racemase Muconate Lactonizing
HYD28_RS00720	COG2863	cytochrome
HYD28_RS00725	COG3122	Protein conserved in bacteria
HYD28_RS00730	COG2814	Major facilitator Superfamily
HYD28_RS00735	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HYD28_RS00765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HYD28_RS00775	COG0330	HflC and HflK could
HYD28_RS00780	COG0330	HflC and HflK could
HYD28_RS00785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYD28_RS00805	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYD28_RS00810	COG0802	atpase or kinase
HYD28_RS00815	COG0439	Biotin carboxylase
HYD28_RS00820	COG0511	ligase activity, forming carbon-carbon bonds
HYD28_RS00830	COG4232	protein-disulfide reductase activity
HYD28_RS00835	COG1324	tolerance protein
HYD28_RS00840	COG3030	protein affecting phage T7 exclusion by the F plasmid
HYD28_RS00860	COG4251	negative regulation of phosphorylation
HYD28_RS00865	COG3620	sequence-specific DNA binding
HYD28_RS00870	COG0784	Response regulator, receiver
HYD28_RS00875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYD28_RS00875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYD28_RS00885	COG1765	OsmC-like protein
HYD28_RS00905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYD28_RS00930	COG2205	protein histidine kinase activity
HYD28_RS00935	COG0745	RESPONSE REGULATOR receiver
HYD28_RS00940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYD28_RS00955	COG2183	response to ionizing radiation
HYD28_RS00970	COG0596	Alpha beta hydrolase
HYD28_RS00975	COG1040	competence protein
HYD28_RS00995	COG0534	Mate efflux family protein
HYD28_RS01000	COG0726	polysaccharide deacetylase
HYD28_RS01005	COG2201	protein-glutamate methylesterase activity
HYD28_RS01010	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYD28_RS01015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYD28_RS01020	COG0840	transmembrane signaling receptor activity
HYD28_RS01025	COG0835	chemotaxis
HYD28_RS01030	COG0643	Histidine kinase
HYD28_RS01030	COG2198	Histidine kinase
HYD28_RS01035	COG0745	RESPONSE REGULATOR receiver
HYD28_RS01045	COG1999	signal sequence binding
HYD28_RS01080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HYD28_RS01085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYD28_RS01090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYD28_RS01135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYD28_RS01135	COG1017	nitric oxide dioxygenase activity
HYD28_RS01145	COG3604	Transcriptional regulator
HYD28_RS01155	COG0431	NADPH-dependent FMN reductase
HYD28_RS01190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYD28_RS01205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYD28_RS01215	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HYD28_RS01220	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYD28_RS01225	COG0545	Peptidyl-prolyl cis-trans isomerase
HYD28_RS01240	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HYD28_RS01260	COG0429	hydrolase of the alpha beta-hydrolase fold
HYD28_RS01265	COG3089	Belongs to the UPF0270 family
HYD28_RS01335	COG0537	adenosine 5'-monophosphoramidase activity
HYD28_RS01375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYD28_RS01410	COG1946	Acyl-CoA thioesterase
HYD28_RS01430	COG0835	chemotaxis
HYD28_RS01430	COG0784	Response regulator, receiver
HYD28_RS01435	COG2031	fatty acid transporter
HYD28_RS01450	COG1253	flavin adenine dinucleotide binding
HYD28_RS01515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYD28_RS01515	COG0456	acetyltransferase
HYD28_RS01545	COG2860	membrane
HYD28_RS01560	COG0436	Aminotransferase
HYD28_RS01570	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HYD28_RS01585	COG3710	Transcriptional regulator
HYD28_RS01590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYD28_RS01595	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HYD28_RS01600	COG0069	glutamate synthase activity
HYD28_RS01635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYD28_RS01640	COG0805	protein transport
HYD28_RS01650	COG0084	hydrolase, TatD family'
HYD28_RS01655	COG3706	GGDEF domain
HYD28_RS01655	COG2203	Gaf domain
HYD28_RS01655	COG4251	negative regulation of phosphorylation
HYD28_RS01655	COG5001	Diguanylate cyclase
HYD28_RS01675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYD28_RS01680	COG4565	transcriptional regulatory protein
HYD28_RS01685	COG3290	protein histidine kinase activity
HYD28_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
HYD28_RS01725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYD28_RS01730	COG2610	gluconate transmembrane transporter activity
HYD28_RS01755	COG0577	efflux transmembrane transporter activity
HYD28_RS01755	COG1136	(ABC) transporter
HYD28_RS01765	COG2204	response regulator
HYD28_RS01770	COG4191	Histidine kinase
HYD28_RS01790	COG5002	protein histidine kinase activity
HYD28_RS01790	COG2198	Histidine kinase
HYD28_RS01790	COG0784	Response regulator, receiver
HYD28_RS01815	COG4681	YaeQ
HYD28_RS01830	COG0783	Belongs to the Dps family
HYD28_RS01840	COG1770	oligopeptidase
HYD28_RS01845	COG3397	chitin binding
HYD28_RS01895	COG0676	glucose-6-phosphate 1-epimerase activity
HYD28_RS01900	COG1846	Transcriptional regulator
HYD28_RS01935	COG2259	Doxx family
HYD28_RS01940	COG1741	Belongs to the pirin family
HYD28_RS01945	COG0583	DNA-binding transcription factor activity
HYD28_RS01960	COG1028	Short-chain dehydrogenase reductase Sdr
HYD28_RS01965	COG2186	Transcriptional regulator
HYD28_RS01975	COG3940	Belongs to the glycosyl hydrolase 43 family
HYD28_RS01980	COG3507	Belongs to the glycosyl hydrolase 43 family
HYD28_RS01995	COG2211	Major facilitator Superfamily
HYD28_RS02000	COG4206	TonB-dependent receptor
HYD28_RS02010	COG3507	Belongs to the glycosyl hydrolase 43 family
HYD28_RS02040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYD28_RS02060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYD28_RS02105	COG4771	TonB-dependent receptor
HYD28_RS02115	COG4946	Tricorn protease homolog
HYD28_RS02115	COG0793	Belongs to the peptidase S41A family
HYD28_RS02120	COG0513	Belongs to the DEAD box helicase family
HYD28_RS02130	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HYD28_RS02135	COG3706	GGDEF domain
HYD28_RS02140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYD28_RS02145	COG1349	DNA-binding transcription factor activity
HYD28_RS02160	COG1136	(ABC) transporter
HYD28_RS02160	COG0577	efflux transmembrane transporter activity
HYD28_RS02175	COG0110	maltose O-acetyltransferase activity
HYD28_RS02200	COG1136	(ABC) transporter
HYD28_RS02200	COG0577	efflux transmembrane transporter activity
HYD28_RS02205	COG1566	PFAM secretion protein HlyD family protein
HYD28_RS02210	COG2204	response regulator
HYD28_RS02215	COG4191	Histidine kinase
HYD28_RS02305	COG1475	DNA binding
HYD28_RS02310	COG1192	Involved in chromosome partitioning
HYD28_RS02330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYD28_RS02340	COG4774	siderophore transport
HYD28_RS02385	COG0187	DNA topoisomerase II activity
HYD28_RS02415	COG1024	Enoyl-CoA hydratase
HYD28_RS02415	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS02420	COG0741	lytic transglycosylase activity
HYD28_RS02425	COG0006	proline dipeptidase activity
HYD28_RS02430	COG1739	Uncharacterized protein family UPF0029
HYD28_RS02435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYD28_RS02465	COG0569	domain protein
HYD28_RS02470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYD28_RS02470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYD28_RS02490	COG0758	DNA mediated transformation
HYD28_RS02500	COG0551	DNA topoisomerase type I activity
HYD28_RS02510	COG0408	coproporphyrinogen oxidase activity
HYD28_RS02520	COG0840	transmembrane signaling receptor activity
HYD28_RS02525	COG2346	COG2346, Truncated hemoglobins
HYD28_RS02540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYD28_RS02580	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYD28_RS02650	COG1522	sequence-specific DNA binding
HYD28_RS02660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYD28_RS02700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYD28_RS02715	COG0386	Belongs to the glutathione peroxidase family
HYD28_RS02720	COG0583	DNA-binding transcription factor activity
HYD28_RS02725	COG1979	alcohol dehydrogenase
HYD28_RS02735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYD28_RS02755	COG1404	Belongs to the peptidase S8 family
HYD28_RS02760	COG1770	oligopeptidase
HYD28_RS02765	COG2205	protein histidine kinase activity
HYD28_RS02770	COG0745	RESPONSE REGULATOR receiver
HYD28_RS02790	COG1238	metal cluster binding
HYD28_RS02795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYD28_RS02835	COG3706	GGDEF domain
HYD28_RS02845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYD28_RS02845	COG3153	acetyltransferase
HYD28_RS02875	COG1187	pseudouridine synthase activity
HYD28_RS02900	COG1011	Hydrolase
HYD28_RS02905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HYD28_RS02920	COG0019	diaminopimelate decarboxylase activity
HYD28_RS02935	COG0400	carboxylic ester hydrolase activity
HYD28_RS02945	COG0181	hydroxymethylbilane synthase activity
HYD28_RS02970	COG0617	tRNA 3'-terminal CCA addition
HYD28_RS02970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYD28_RS02970	COG0517	IMP dehydrogenase activity
HYD28_RS02990	COG2354	Protein conserved in bacteria
HYD28_RS03005	COG0513	Belongs to the DEAD box helicase family
HYD28_RS03015	COG3437	response regulator, receiver
HYD28_RS03015	COG3850	Histidine kinase
HYD28_RS03015	COG4999	Histidine kinase
HYD28_RS03015	COG2205	protein histidine kinase activity
HYD28_RS03020	COG0840	transmembrane signaling receptor activity
HYD28_RS03030	COG3118	belongs to the thioredoxin family
HYD28_RS03035	COG0513	Belongs to the DEAD box helicase family
HYD28_RS03070	COG1444	tRNA N-acetyltransferase activity
HYD28_RS03075	COG0210	DNA helicase
HYD28_RS03085	COG3112	Uncharacterised protein family (UPF0231)
HYD28_RS03100	COG1011	Hydrolase
HYD28_RS03105	COG0494	nUDIX hydrolase
HYD28_RS03110	COG1218	3'(2'),5'-bisphosphate nucleotidase
HYD28_RS03155	COG0175	sulfate reduction
HYD28_RS03180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYD28_RS03210	COG2204	response regulator
HYD28_RS03215	COG3852	Histidine kinase
HYD28_RS03225	COG0174	glutamine synthetase
HYD28_RS03240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYD28_RS03265	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYD28_RS03270	COG0456	acetyltransferase
HYD28_RS03285	COG0019	diaminopimelate decarboxylase activity
HYD28_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYD28_RS03310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYD28_RS03310	COG2885	chlorophyll binding
HYD28_RS03315	COG2885	chlorophyll binding
HYD28_RS03340	COG1082	Xylose isomerase domain protein TIM barrel
HYD28_RS03355	COG0840	transmembrane signaling receptor activity
HYD28_RS03360	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYD28_RS03365	COG1166	arginine decarboxylase activity
HYD28_RS03370	COG0204	Acyl-transferase
HYD28_RS03375	COG0204	Acyl-transferase
HYD28_RS03380	COG0668	transmembrane transport
HYD28_RS03400	COG1132	(ABC) transporter
HYD28_RS03445	COG0640	Transcriptional regulator
HYD28_RS03470	COG3021	interspecies interaction between organisms
HYD28_RS03485	COG0577	efflux transmembrane transporter activity
HYD28_RS03490	COG1136	(ABC) transporter
HYD28_RS03495	COG1566	PFAM secretion protein HlyD family protein
HYD28_RS03505	COG4989	oxidoreductase activity
HYD28_RS03585	COG0201	protein transport
HYD28_RS03590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYD28_RS03645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYD28_RS03650	COG3031	protein transport across the cell outer membrane
HYD28_RS03660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYD28_RS03665	COG1459	type II secretion system
HYD28_RS03670	COG2165	general secretion pathway protein
HYD28_RS03680	COG2165	general secretion pathway protein
HYD28_RS03725	COG0348	domain, Protein
HYD28_RS03730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYD28_RS03740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYD28_RS03745	COG1683	Conserved Protein
HYD28_RS03760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYD28_RS03765	COG0724	RNA recognition motif
HYD28_RS03795	COG0814	amino acid
HYD28_RS03805	COG1218	3'(2'),5'-bisphosphate nucleotidase
HYD28_RS03810	COG0529	Catalyzes the synthesis of activated sulfate
HYD28_RS03815	COG0471	metal ion transport
HYD28_RS03815	COG3273	potassium ion transport
HYD28_RS03820	COG2895	sulfate adenylyltransferase (ATP) activity
HYD28_RS03835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYD28_RS03850	COG0745	RESPONSE REGULATOR receiver
HYD28_RS03850	COG2205	protein histidine kinase activity
HYD28_RS03850	COG3292	Two component regulator propeller
HYD28_RS03850	COG0745	RESPONSE REGULATOR receiver
HYD28_RS03850	COG2205	protein histidine kinase activity
HYD28_RS03850	COG3292	Two component regulator propeller
HYD28_RS03860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYD28_RS03865	COG0250	Participates in transcription elongation, termination and antitermination
HYD28_RS03920	COG1785	Belongs to the alkaline phosphatase family
HYD28_RS03925	COG1785	Belongs to the alkaline phosphatase family
HYD28_RS03965	COG1119	ATPase activity
HYD28_RS03980	COG3978	acetolactate synthase activity
HYD28_RS03990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYD28_RS04005	COG0288	reversible hydration of carbon dioxide
HYD28_RS04035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYD28_RS04035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYD28_RS04040	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HYD28_RS04100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYD28_RS04120	COG1509	lysine 2,3-aminomutase activity
HYD28_RS04135	COG4774	siderophore transport
HYD28_RS04135	COG1629	transport
HYD28_RS04175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYD28_RS04185	COG1162	GTPase activity
HYD28_RS04215	COG0432	Pfam Uncharacterised protein family UPF0047
HYD28_RS04225	COG0735	belongs to the Fur family
HYD28_RS04230	COG2095	MarC family integral membrane protein
HYD28_RS04240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYD28_RS04245	COG1842	Phage shock protein A
HYD28_RS04285	COG5001	Diguanylate cyclase
HYD28_RS04285	COG3300	MHYT domain
HYD28_RS04290	COG1032	radical SAM domain protein
HYD28_RS04295	COG2239	Acts as a magnesium transporter
HYD28_RS04300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYD28_RS04310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYD28_RS04315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYD28_RS04320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYD28_RS04325	COG1137	ATPase activity
HYD28_RS04340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HYD28_RS04345	COG0517	IMP dehydrogenase activity
HYD28_RS04345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYD28_RS04355	COG1127	ABC transporter
HYD28_RS04360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYD28_RS04365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYD28_RS04370	COG2854	intermembrane phospholipid transfer
HYD28_RS04375	COG3113	response to antibiotic
HYD28_RS04380	COG5007	Belongs to the BolA IbaG family
HYD28_RS04395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYD28_RS04405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HYD28_RS04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYD28_RS04445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYD28_RS04475	COG0671	phosphoesterase, PA-phosphatase related
HYD28_RS04510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYD28_RS04520	COG0281	malic enzyme
HYD28_RS04530	COG0626	cystathionine gamma-synthase activity
HYD28_RS04535	COG0460	homoserine dehydrogenase
HYD28_RS04535	COG0527	aspartate kinase activity
HYD28_RS04545	COG1077	Cell shape determining protein MreB Mrl
HYD28_RS04585	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HYD28_RS04600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYD28_RS04610	COG0180	Tryptophanyl-tRNA synthetase
HYD28_RS04635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYD28_RS04640	COG2814	Major facilitator Superfamily
HYD28_RS04645	COG0629	single-stranded DNA binding
HYD28_RS04650	COG1716	ATPase activity
HYD28_RS04650	COG5001	Diguanylate cyclase
HYD28_RS04655	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYD28_RS04665	COG1077	Cell shape determining protein MreB Mrl
HYD28_RS04670	COG1792	Involved in formation and maintenance of cell shape
HYD28_RS04675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HYD28_RS04685	COG1530	ribonuclease E activity
HYD28_RS04690	COG3164	Protein of unknown function
HYD28_RS04695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYD28_RS04700	COG0312	modulator of DNA gyrase
HYD28_RS04715	COG4753	response regulator
HYD28_RS04715	COG2207	Transcriptional regulator
HYD28_RS04720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYD28_RS04725	COG0339	signal peptide processing
HYD28_RS04745	COG0678	peroxiredoxin activity
HYD28_RS04750	COG1404	Belongs to the peptidase S8 family
HYD28_RS04755	COG2081	HI0933 family
HYD28_RS04760	COG3300	MHYT domain
HYD28_RS04760	COG5001	Diguanylate cyclase
HYD28_RS04770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HYD28_RS04775	COG4946	Tricorn protease homolog
HYD28_RS04775	COG1506	peptidase
HYD28_RS04775	COG0823	Involved in the tonB-independent uptake of proteins
HYD28_RS04785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYD28_RS04795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYD28_RS04810	COG2965	DNA replication, synthesis of RNA primer
HYD28_RS04830	COG4969	Belongs to the N-Me-Phe pilin family
HYD28_RS04865	COG0305	Participates in initiation and elongation during chromosome replication
HYD28_RS04905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYD28_RS04915	COG5002	protein histidine kinase activity
HYD28_RS04925	COG3713	MltA-interacting MipA family protein
HYD28_RS04935	COG4067	protein conserved in archaea
HYD28_RS04935	COG0189	ligase activity
HYD28_RS04965	COG0514	ATP-dependent DNA helicase (RecQ)
HYD28_RS04970	COG2962	Rard protein
HYD28_RS04985	COG0583	DNA-binding transcription factor activity
HYD28_RS04995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYD28_RS05000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYD28_RS05005	COG1522	sequence-specific DNA binding
HYD28_RS05010	COG2502	aspartate--ammonia ligase
HYD28_RS05025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYD28_RS05040	COG1561	YicC-like family, N-terminal region
HYD28_RS05075	COG0793	Belongs to the peptidase S41A family
HYD28_RS05080	COG4942	peptidase
HYD28_RS05090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYD28_RS05095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HYD28_RS05115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYD28_RS05125	COG2267	carboxylic ester hydrolase activity
HYD28_RS05130	COG2205	protein histidine kinase activity
HYD28_RS05135	COG0745	RESPONSE REGULATOR receiver
HYD28_RS05150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYD28_RS05160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYD28_RS05175	COG0157	Belongs to the NadC ModD family
HYD28_RS05180	COG3023	N-Acetylmuramoyl-L-alanine amidase
HYD28_RS05185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HYD28_RS05190	COG2186	Transcriptional regulator
HYD28_RS05195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HYD28_RS05200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYD28_RS05205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYD28_RS05215	COG1840	ABC-type Fe3 transport system, periplasmic component
HYD28_RS05225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HYD28_RS05235	COG1438	arginine binding
HYD28_RS05245	COG0142	geranyltranstransferase activity
HYD28_RS05280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYD28_RS05285	COG2967	ApaG domain
HYD28_RS05320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HYD28_RS05330	COG0564	pseudouridine synthase activity
HYD28_RS05340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYD28_RS05345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYD28_RS05350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYD28_RS05405	COG2871	sodium ion transport
HYD28_RS05425	COG2132	Multicopper oxidase
HYD28_RS05440	COG0789	Transcriptional regulator
HYD28_RS05445	COG2217	Heavy metal translocating P-type atpase
HYD28_RS05495	COG0789	Transcriptional regulator
HYD28_RS05600	COG3437	response regulator, receiver
HYD28_RS05610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYD28_RS05615	COG0789	Transcriptional regulator
HYD28_RS05630	COG3313	Fe-S protein
HYD28_RS05655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYD28_RS05660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYD28_RS05660	COG0045	succinate-CoA ligase (ADP-forming) activity
HYD28_RS05660	COG1042	CoA-binding domain protein
HYD28_RS05685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYD28_RS05690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYD28_RS05700	COG0762	integral membrane protein
HYD28_RS05705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYD28_RS05740	COG0189	ligase activity
HYD28_RS05745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYD28_RS05760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HYD28_RS05770	COG1560	Kdo2-lipid A biosynthetic process
HYD28_RS05775	COG1538	Outer membrane efflux protein
HYD28_RS05780	COG0494	nUDIX hydrolase
HYD28_RS05785	COG3151	Protein conserved in bacteria
HYD28_RS05795	COG3150	esterase
HYD28_RS05800	COG0187	DNA topoisomerase II activity
HYD28_RS05810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYD28_RS05820	COG0204	Acyl-transferase
HYD28_RS05850	COG2927	DNA polymerase III (CHI subunit)
HYD28_RS05855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYD28_RS05860	COG0795	lipopolysaccharide-transporting ATPase activity
HYD28_RS05865	COG0795	lipopolysaccharide-transporting ATPase activity
HYD28_RS05875	COG1960	acyl-CoA dehydrogenase activity
HYD28_RS05885	COG5001	Diguanylate cyclase
HYD28_RS05885	COG3300	MHYT domain
HYD28_RS05900	COG2807	transmembrane transport
HYD28_RS05930	COG1012	belongs to the aldehyde dehydrogenase family
HYD28_RS05935	COG2070	2-Nitropropane dioxygenase
HYD28_RS05955	COG2204	response regulator
HYD28_RS05965	COG4251	negative regulation of phosphorylation
HYD28_RS05970	COG0784	Response regulator, receiver
HYD28_RS05975	COG0784	Response regulator, receiver
HYD28_RS05975	COG2205	protein histidine kinase activity
HYD28_RS05980	COG1609	Transcriptional regulator
HYD28_RS05985	COG2211	Major facilitator Superfamily
HYD28_RS06000	COG1472	Belongs to the glycosyl hydrolase 3 family
HYD28_RS06030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYD28_RS06045	COG0492	ferredoxin-NADP+ reductase activity
HYD28_RS06050	COG0385	Bile acid
HYD28_RS06055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYD28_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
HYD28_RS06075	COG0667	Aldo Keto reductase
HYD28_RS06095	COG1966	Carbon starvation protein
HYD28_RS06100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYD28_RS06105	COG0840	transmembrane signaling receptor activity
HYD28_RS06140	COG4191	Histidine kinase
HYD28_RS06145	COG2201	protein-glutamate methylesterase activity
HYD28_RS06160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYD28_RS06180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYD28_RS06180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYD28_RS06210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYD28_RS06215	COG3706	GGDEF domain
HYD28_RS06225	COG0142	geranyltranstransferase activity
HYD28_RS06235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYD28_RS06250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYD28_RS06255	COG1473	amidohydrolase
HYD28_RS06260	COG3118	belongs to the thioredoxin family
HYD28_RS06295	COG1120	ATPase activity
HYD28_RS06300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYD28_RS06310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYD28_RS06325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HYD28_RS06330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYD28_RS06355	COG0668	transmembrane transport
HYD28_RS06360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYD28_RS06365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HYD28_RS06370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYD28_RS06395	COG0004	ammonium transporteR
HYD28_RS06405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYD28_RS06420	COG0540	Belongs to the ATCase OTCase family
HYD28_RS06460	COG2211	Major facilitator Superfamily
HYD28_RS06485	COG0271	Belongs to the BolA IbaG family
HYD28_RS06500	COG1805	sodium ion transport
HYD28_RS06505	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HYD28_RS06520	COG2871	sodium ion transport
HYD28_RS06525	COG1477	protein flavinylation
HYD28_RS06550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYD28_RS06575	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYD28_RS06585	COG0488	(ABC) transporter
HYD28_RS06595	COG1410	methionine synthase
HYD28_RS06595	COG0646	methionine synthase
HYD28_RS06600	COG0646	methionine synthase
HYD28_RS06600	COG1410	methionine synthase
HYD28_RS06605	COG3706	GGDEF domain
HYD28_RS06610	COG3237	CsbD-like
HYD28_RS06620	COG1643	Atp-dependent helicase
HYD28_RS06630	COG1902	pentaerythritol trinitrate reductase activity
HYD28_RS06635	COG0583	DNA-binding transcription factor activity
HYD28_RS06640	COG2814	Major facilitator Superfamily
HYD28_RS06680	COG3507	Belongs to the glycosyl hydrolase 43 family
HYD28_RS06695	COG0668	transmembrane transport
HYD28_RS06700	COG1346	cytolysis
HYD28_RS06710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS06710	COG1024	Enoyl-CoA hydratase
HYD28_RS06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYD28_RS06740	COG1047	Peptidyl-prolyl cis-trans
HYD28_RS06750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HYD28_RS06760	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYD28_RS06765	COG1595	DNA-templated transcription, initiation
HYD28_RS06775	COG3026	antisigma factor binding
HYD28_RS06790	COG0681	Belongs to the peptidase S26 family
HYD28_RS06825	COG4999	Histidine kinase
HYD28_RS06825	COG3850	Histidine kinase
HYD28_RS06825	COG3437	response regulator, receiver
HYD28_RS06825	COG2205	protein histidine kinase activity
HYD28_RS06835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYD28_RS06840	COG3956	TIGRFAM MazG family protein
HYD28_RS06855	COG3066	DNA modification
HYD28_RS06870	COG0730	response to heat
HYD28_RS06885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYD28_RS06920	COG1063	alcohol dehydrogenase
HYD28_RS06930	COG0678	peroxiredoxin activity
HYD28_RS06930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HYD28_RS06935	COG0583	DNA-binding transcription factor activity
HYD28_RS06960	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HYD28_RS06965	COG0784	Response regulator, receiver
HYD28_RS06965	COG0835	chemotaxis
HYD28_RS06970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYD28_RS06975	COG1815	bacterial-type flagellum-dependent cell motility
HYD28_RS06995	COG4787	bacterial-type flagellum-dependent cell motility
HYD28_RS07015	COG1705	Flagellar rod assembly protein muramidase FlgJ
HYD28_RS07015	COG3951	Flagellar rod assembly protein muramidase FlgJ
HYD28_RS07030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYD28_RS07035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYD28_RS07040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYD28_RS07055	COG1516	flagellar protein fliS
HYD28_RS07075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYD28_RS07085	COG0562	UDP-galactopyranose mutase
HYD28_RS07095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYD28_RS07100	COG2089	acid synthase
HYD28_RS07150	COG0519	Catalyzes the synthesis of GMP from XMP
HYD28_RS07155	COG3852	Histidine kinase
HYD28_RS07165	COG1677	Flagellar hook-basal body complex protein FliE
HYD28_RS07175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYD28_RS07195	COG3144	bacterial-type flagellum assembly
HYD28_RS07215	COG3190	flagellar
HYD28_RS07225	COG1987	bacterial-type flagellum assembly
HYD28_RS07240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYD28_RS07265	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HYD28_RS07270	COG0643	Histidine kinase
HYD28_RS07270	COG0784	Response regulator, receiver
HYD28_RS07270	COG2198	Histidine kinase
HYD28_RS07280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYD28_RS07290	COG1192	Involved in chromosome partitioning
HYD28_RS07300	COG0835	chemotaxis
HYD28_RS07320	COG4133	protoheme IX ABC transporter activity
HYD28_RS07325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYD28_RS07330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYD28_RS07335	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYD28_RS07345	COG1138	Cytochrome C-type biogenesis protein
HYD28_RS07365	COG2853	Lipoprotein
HYD28_RS07370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HYD28_RS07375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYD28_RS07380	COG3141	response to X-ray
HYD28_RS07385	COG1555	photosystem II stabilization
HYD28_RS07400	COG1605	Chorismate mutase
HYD28_RS07400	COG0077	Prephenate dehydratase
HYD28_RS07410	COG0023	Translation Initiation Factor
HYD28_RS07430	COG1448	Aminotransferase
HYD28_RS07450	COG2304	oxidoreductase activity
HYD28_RS07455	COG2304	oxidoreductase activity
HYD28_RS07470	COG0714	Associated with various cellular activities
HYD28_RS07480	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS07480	COG1024	Enoyl-CoA hydratase
HYD28_RS07490	COG2315	Protein conserved in bacteria
HYD28_RS07520	COG0714	Associated with various cellular activities
HYD28_RS07540	COG1025	Belongs to the peptidase M16 family
HYD28_RS07545	COG2062	phosphohistidine phosphatase, SixA
HYD28_RS07550	COG0251	oxidation-reduction process
HYD28_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
HYD28_RS07575	COG2890	protein-(glutamine-N5) methyltransferase activity
HYD28_RS07595	COG0583	DNA-binding transcription factor activity
HYD28_RS07610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYD28_RS07615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYD28_RS07615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYD28_RS07620	COG3101	peptidyl-lysine hydroxylation
HYD28_RS07635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYD28_RS07655	COG0071	Belongs to the small heat shock protein (HSP20) family
HYD28_RS07660	COG3046	protein related to deoxyribodipyrimidine photolyase
HYD28_RS07680	COG0195	Participates in both transcription termination and antitermination
HYD28_RS07720	COG2111	Na H antiporter
HYD28_RS07720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYD28_RS07725	COG1006	Multisubunit Na H antiporter MnhC subunit
HYD28_RS07730	COG0651	ATP synthesis coupled electron transport
HYD28_RS07740	COG2212	antiporter activity
HYD28_RS07760	COG0285	dihydrofolate synthase activity
HYD28_RS07770	COG1286	toxin biosynthetic process
HYD28_RS07775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYD28_RS07785	COG0668	transmembrane transport
HYD28_RS07790	COG4771	TonB-dependent receptor
HYD28_RS07810	COG0443	Heat shock 70 kDa protein
HYD28_RS07820	COG1280	lysine exporter protein (LysE YggA)
HYD28_RS07825	COG1404	Belongs to the peptidase S8 family
HYD28_RS07845	COG0739	heme binding
HYD28_RS07850	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYD28_RS07865	COG3104	oligopeptide transport
HYD28_RS07870	COG0457	Tetratricopeptide repeat
HYD28_RS07870	COG3118	belongs to the thioredoxin family
HYD28_RS07875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HYD28_RS07885	COG1215	transferase activity, transferring glycosyl groups
HYD28_RS07905	COG2194	sulfuric ester hydrolase activity
HYD28_RS07970	COG3047	cAMP biosynthetic process
HYD28_RS07975	COG0534	Mate efflux family protein
HYD28_RS07990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYD28_RS08010	COG2201	protein-glutamate methylesterase activity
HYD28_RS08020	COG0728	peptidoglycan biosynthetic process
HYD28_RS08025	COG0196	riboflavin kinase activity
HYD28_RS08040	COG1047	Peptidyl-prolyl cis-trans
HYD28_RS08050	COG0745	RESPONSE REGULATOR receiver
HYD28_RS08050	COG2972	Histidine kinase
HYD28_RS08105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYD28_RS08110	COG0564	pseudouridine synthase activity
HYD28_RS08120	COG0542	response to heat
HYD28_RS08125	COG0840	transmembrane signaling receptor activity
HYD28_RS08145	COG0602	queuosine metabolic process
HYD28_RS08155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYD28_RS08160	COG2716	regulation of RNA biosynthetic process
HYD28_RS08180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYD28_RS08185	COG2854	intermembrane phospholipid transfer
HYD28_RS08205	COG1393	Belongs to the ArsC family
HYD28_RS08210	COG4783	chaperone-mediated protein folding
HYD28_RS08230	COG1609	Transcriptional regulator
HYD28_RS08240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HYD28_RS08245	COG0363	glucosamine-6-phosphate deaminase activity
HYD28_RS08270	COG1446	asparaginase
HYD28_RS08285	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HYD28_RS08330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYD28_RS08335	COG1196	nuclear chromosome segregation
HYD28_RS08340	COG3115	cell septum assembly
HYD28_RS08365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYD28_RS08370	COG2205	protein histidine kinase activity
HYD28_RS08370	COG0784	Response regulator, receiver
HYD28_RS08470	COG1131	(ABC) transporter
HYD28_RS08475	COG0842	Transport permease protein
HYD28_RS08485	COG5002	protein histidine kinase activity
HYD28_RS08485	COG0784	Response regulator, receiver
HYD28_RS08490	COG0346	lactoylglutathione lyase activity
HYD28_RS08495	COG1982	Orn Lys Arg decarboxylase major
HYD28_RS08510	COG3706	GGDEF domain
HYD28_RS08515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYD28_RS08520	COG4660	Part of a membrane complex involved in electron transport
HYD28_RS08525	COG4659	FMN binding
HYD28_RS08530	COG4658	electron transport chain
HYD28_RS08535	COG4656	Part of a membrane complex involved in electron transport
HYD28_RS08540	COG2878	Part of a membrane complex involved in electron transport
HYD28_RS08550	COG2200	EAL domain
HYD28_RS08550	COG2771	luxR family
HYD28_RS08575	COG0534	Mate efflux family protein
HYD28_RS08585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYD28_RS08615	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYD28_RS08625	COG0730	response to heat
HYD28_RS08630	COG1199	ATP-dependent helicase activity
HYD28_RS08635	COG0457	Tetratricopeptide repeat
HYD28_RS08640	COG0417	DNA replication proofreading
HYD28_RS08645	COG4771	TonB-dependent receptor
HYD28_RS08695	COG1061	Type III restriction enzyme res subunit
HYD28_RS08705	COG0729	surface antigen
HYD28_RS08715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYD28_RS08720	COG1643	Atp-dependent helicase
HYD28_RS08740	COG1418	mRNA catabolic process
HYD28_RS08750	COG3437	response regulator, receiver
HYD28_RS08755	COG2205	protein histidine kinase activity
HYD28_RS08755	COG2198	Histidine kinase
HYD28_RS08755	COG0784	Response regulator, receiver
HYD28_RS08810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYD28_RS08825	COG2197	response regulator
HYD28_RS08885	COG1115	amino acid carrier protein
HYD28_RS08915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYD28_RS08940	COG2866	Carboxypeptidase
HYD28_RS08945	COG1115	amino acid carrier protein
HYD28_RS08955	COG3139	Protein of unknown function (DUF1315)
HYD28_RS08970	COG3604	Transcriptional regulator
HYD28_RS08995	COG0628	permease
HYD28_RS09005	COG2205	protein histidine kinase activity
HYD28_RS09010	COG0745	RESPONSE REGULATOR receiver
HYD28_RS09020	COG2350	Protein conserved in bacteria
HYD28_RS09025	COG0733	neurotransmitter:sodium symporter activity
HYD28_RS09035	COG2917	probably involved in intracellular septation
HYD28_RS09040	COG0776	regulation of translation
HYD28_RS09045	COG0693	protein deglycase activity
HYD28_RS09060	COG0135	phosphoribosylanthranilate isomerase activity
HYD28_RS09060	COG0134	indole-3-glycerol-phosphate synthase activity
HYD28_RS09070	COG0512	Glutamine amidotransferase of anthranilate synthase
HYD28_RS09075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYD28_RS09080	COG0613	PHP domain protein
HYD28_RS09085	COG0009	L-threonylcarbamoyladenylate synthase
HYD28_RS09110	COG3038	cytochrome b561
HYD28_RS09145	COG1629	transport
HYD28_RS09145	COG4774	siderophore transport
HYD28_RS09190	COG1476	TRANSCRIPTIONal
HYD28_RS09215	COG0489	protein tyrosine kinase activity
HYD28_RS09240	COG5001	Diguanylate cyclase
HYD28_RS09240	COG4251	negative regulation of phosphorylation
HYD28_RS09240	COG3706	GGDEF domain
HYD28_RS09240	COG2203	Gaf domain
HYD28_RS09260	COG0436	Aminotransferase
HYD28_RS09265	COG3134	Outer membrane lipoprotein
HYD28_RS09290	COG1876	peptidase activity
HYD28_RS09300	COG1393	Belongs to the ArsC family
HYD28_RS09315	COG0280	phosphate acetyltransferase
HYD28_RS09315	COG0857	belongs to the CobB CobQ family
HYD28_RS09320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYD28_RS09325	COG3092	negative regulation of chromosome organization
HYD28_RS09330	COG2226	methyltransferase
HYD28_RS09355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYD28_RS09360	COG1187	pseudouridine synthase activity
HYD28_RS09365	COG0686	Belongs to the AlaDH PNT family
HYD28_RS09375	COG1674	ftsk spoiiie
HYD28_RS09375	COG0531	amino acid
HYD28_RS09385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYD28_RS09410	COG0641	radical SAM
HYD28_RS09420	COG2755	lipolytic protein G-D-S-L family
HYD28_RS09425	COG4181	ATPase activity
HYD28_RS09430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HYD28_RS09450	COG0811	peptide transport
HYD28_RS09470	COG2885	chlorophyll binding
HYD28_RS09475	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HYD28_RS09545	COG2207	Transcriptional regulator
HYD28_RS09560	COG1902	pentaerythritol trinitrate reductase activity
HYD28_RS09580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HYD28_RS09585	COG1074	ATP-dependent DNA helicase activity
HYD28_RS09590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYD28_RS09600	COG2860	membrane
HYD28_RS09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYD28_RS09625	COG0300	oxidoreductase activity
HYD28_RS09635	COG1505	serine-type exopeptidase activity
HYD28_RS09645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYD28_RS09680	COG0589	response to stress
HYD28_RS09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYD28_RS09710	COG2010	Cytochrome c
HYD28_RS09725	COG3278	Belongs to the heme-copper respiratory oxidase family
HYD28_RS09755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYD28_RS09780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYD28_RS09800	COG0848	biopolymer transport protein
HYD28_RS09835	COG3344	reverse transcriptase
HYD28_RS09860	COG3083	sulfuric ester hydrolase activity
HYD28_RS09870	COG3081	Nucleoid-associated protein
HYD28_RS09885	COG0662	Cupin 2, conserved barrel domain protein
HYD28_RS09890	COG0384	phenazine biosynthesis protein PhzF
HYD28_RS09895	COG1530	ribonuclease E activity
HYD28_RS09905	COG0546	phosphoglycolate phosphatase activity
HYD28_RS09915	COG1399	metal-binding, possibly nucleic acid-binding protein
HYD28_RS09930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYD28_RS09940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYD28_RS09945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYD28_RS09950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYD28_RS09955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYD28_RS09965	COG0470	DNA polymerase III
HYD28_RS09975	COG0084	hydrolase, TatD family'
HYD28_RS09985	COG0726	polysaccharide deacetylase
HYD28_RS10000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYD28_RS10005	COG0372	Belongs to the citrate synthase family
HYD28_RS10010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYD28_RS10015	COG2828	Protein conserved in bacteria
HYD28_RS10055	COG0307	riboflavin synthase, alpha
HYD28_RS10065	COG3001	Fructosamine kinase
HYD28_RS10085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYD28_RS10115	COG1132	(ABC) transporter
HYD28_RS10145	COG2205	protein histidine kinase activity
HYD28_RS10160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYD28_RS10170	COG0318	PFAM AMP-dependent synthetase and ligase
HYD28_RS10210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYD28_RS10215	COG1522	sequence-specific DNA binding
HYD28_RS10220	COG0659	secondary active sulfate transmembrane transporter activity
HYD28_RS10225	COG3275	phosphorelay sensor kinase activity
HYD28_RS10235	COG0469	pyruvate kinase activity
HYD28_RS10240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYD28_RS10245	COG0252	asparaginase activity
HYD28_RS10250	COG0616	signal peptide processing
HYD28_RS10255	COG1902	pentaerythritol trinitrate reductase activity
HYD28_RS10255	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYD28_RS10265	COG0778	Nitroreductase
HYD28_RS10285	COG0545	Peptidyl-prolyl cis-trans isomerase
HYD28_RS10290	COG0735	belongs to the Fur family
HYD28_RS10295	COG0716	FMN binding
HYD28_RS10310	COG0596	Alpha beta hydrolase
HYD28_RS10320	COG0033	Phosphoglucomutase
HYD28_RS10330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYD28_RS10335	COG0022	dehydrogenase e1 component
HYD28_RS10360	COG4555	ABC transporter
HYD28_RS10365	COG1668	transmembrane transport
HYD28_RS10385	COG1720	tRNA m6t6A37 methyltransferase activity
HYD28_RS10445	COG2226	methyltransferase
HYD28_RS10455	COG0501	Belongs to the peptidase M48B family
HYD28_RS10480	COG2329	Antibiotic biosynthesis monooxygenase
HYD28_RS10490	COG1309	transcriptional regulator
HYD28_RS10495	COG0488	(ABC) transporter
HYD28_RS10500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYD28_RS10505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYD28_RS10515	COG2855	membrane
HYD28_RS10540	COG0405	Gamma-glutamyltransferase
HYD28_RS10545	COG0281	malic enzyme
HYD28_RS10605	COG0488	(ABC) transporter
HYD28_RS10615	COG2201	protein-glutamate methylesterase activity
HYD28_RS10635	COG2056	Na+-H+ antiporter family
HYD28_RS10640	COG2205	protein histidine kinase activity
HYD28_RS10640	COG0784	Response regulator, receiver
HYD28_RS10660	COG2204	response regulator
HYD28_RS10690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYD28_RS10695	COG0438	transferase activity, transferring glycosyl groups
HYD28_RS10710	COG0110	maltose O-acetyltransferase activity
HYD28_RS10725	COG0438	transferase activity, transferring glycosyl groups
HYD28_RS10730	COG1215	transferase activity, transferring glycosyl groups
HYD28_RS10735	COG3437	response regulator, receiver
HYD28_RS10750	COG1607	acyl-coa hydrolase
HYD28_RS10755	COG0739	heme binding
HYD28_RS10770	COG3130	regulation of translation
HYD28_RS10775	COG1309	transcriptional regulator
HYD28_RS10780	COG0604	alcohol dehydrogenase
HYD28_RS10785	COG4628	conserved protein (DUF2132)
HYD28_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
HYD28_RS10820	COG1024	Enoyl-CoA hydratase
HYD28_RS10820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYD28_RS10825	COG1024	Enoyl-CoA hydratase
HYD28_RS10840	COG0183	Belongs to the thiolase family
HYD28_RS10855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYD28_RS10860	COG1024	Enoyl-CoA hydratase
HYD28_RS10865	COG4770	biotin carboxylase activity
HYD28_RS10875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYD28_RS10885	COG0583	DNA-binding transcription factor activity
HYD28_RS10915	COG3710	Transcriptional regulator
HYD28_RS10935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYD28_RS10940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HYD28_RS10945	COG1984	allophanate hydrolase subunit 2
HYD28_RS10950	COG0367	asparagine synthase
HYD28_RS10955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYD28_RS10960	COG2176	DNA-directed DNA polymerase activity
HYD28_RS10990	COG0513	Belongs to the DEAD box helicase family
HYD28_RS11000	COG3344	reverse transcriptase
HYD28_RS11015	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HYD28_RS11030	COG0539	negative regulation of cytoplasmic translation
HYD28_RS11035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYD28_RS11065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYD28_RS11070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYD28_RS11075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYD28_RS11100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYD28_RS11100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HYD28_RS11105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYD28_RS11115	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYD28_RS11120	COG0567	Dehydrogenase, E1 component
HYD28_RS11130	COG1053	succinate dehydrogenase
HYD28_RS11135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HYD28_RS11150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYD28_RS11155	COG2166	iron-sulfur cluster assembly
HYD28_RS11160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYD28_RS11165	COG0564	pseudouridine synthase activity
HYD28_RS11190	COG2333	competence protein COMEC
HYD28_RS11190	COG0658	competence protein
HYD28_RS11230	COG2902	Dehydrogenase
HYD28_RS11260	COG0308	aminopeptidase N
HYD28_RS11275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HYD28_RS11285	COG1956	GAF domain-containing protein
HYD28_RS11305	COG0670	Belongs to the BI1 family
HYD28_RS11315	COG2923	Belongs to the DsrF TusC family
HYD28_RS11320	COG2168	tRNA wobble position uridine thiolation
HYD28_RS11325	COG2920	part of a sulfur-relay system
HYD28_RS11330	COG1187	pseudouridine synthase activity
HYD28_RS11355	COG2850	peptidyl-arginine hydroxylation
HYD28_RS11375	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYD28_RS11385	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYD28_RS11390	COG0583	DNA-binding transcription factor activity
HYD28_RS11415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYD28_RS11420	COG1285	pathogenesis
HYD28_RS11455	COG1285	pathogenesis
HYD28_RS11465	COG0189	ligase activity
HYD28_RS11470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYD28_RS11475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYD28_RS11480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYD28_RS11490	COG1064	alcohol dehydrogenase
HYD28_RS11495	COG5265	(ABC) transporter
HYD28_RS11535	COG1609	Transcriptional regulator
HYD28_RS11540	COG0837	glucose binding
HYD28_RS11545	COG1609	Transcriptional regulator
HYD28_RS11550	COG1944	ATP diphosphatase activity
HYD28_RS11580	COG0366	Alpha amylase catalytic
HYD28_RS11595	COG0366	Alpha amylase catalytic
HYD28_RS11600	COG2862	Uncharacterized protein family, UPF0114
HYD28_RS11615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYD28_RS11635	COG0616	signal peptide processing
HYD28_RS11640	COG2267	carboxylic ester hydrolase activity
HYD28_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
HYD28_RS11650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYD28_RS11655	COG0492	ferredoxin-NADP+ reductase activity
HYD28_RS11665	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HYD28_RS11675	COG0542	response to heat
HYD28_RS11680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYD28_RS11685	COG1278	Cold shock
HYD28_RS11695	COG3437	response regulator, receiver
HYD28_RS11695	COG4999	Histidine kinase
HYD28_RS11695	COG3850	Histidine kinase
HYD28_RS11695	COG2205	protein histidine kinase activity
HYD28_RS11705	COG2205	protein histidine kinase activity
HYD28_RS11705	COG0784	Response regulator, receiver
HYD28_RS11715	COG1090	epimerase
HYD28_RS11725	COG0583	DNA-binding transcription factor activity
HYD28_RS11870	COG4695	Portal protein
HYD28_RS11895	COG3706	GGDEF domain
HYD28_RS11930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYD28_RS11965	COG0582	viral genome integration into host DNA
HYD28_RS11970	COG2925	Exonuclease
HYD28_RS11975	COG2084	Dehydrogenase
HYD28_RS11980	COG0386	Belongs to the glutathione peroxidase family
HYD28_RS11985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYD28_RS11990	COG0733	neurotransmitter:sodium symporter activity
HYD28_RS12000	COG0527	aspartate kinase activity
HYD28_RS12005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYD28_RS12040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYD28_RS12065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYD28_RS12070	COG0583	DNA-binding transcription factor activity
HYD28_RS12090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYD28_RS12095	COG0505	Belongs to the CarA family
HYD28_RS12120	COG2814	Major facilitator Superfamily
HYD28_RS12130	COG1420	regulation of RNA biosynthetic process
HYD28_RS12145	COG0497	DNA recombination
HYD28_RS12165	COG2205	protein histidine kinase activity
HYD28_RS12175	COG0745	RESPONSE REGULATOR receiver
HYD28_RS12185	COG0493	'glutamate synthase
HYD28_RS12190	COG0069	glutamate synthase activity
HYD28_RS12190	COG0067	glutamate synthase
HYD28_RS12190	COG0070	glutamate synthase
HYD28_RS12200	COG1136	(ABC) transporter
HYD28_RS12205	COG0577	efflux transmembrane transporter activity
HYD28_RS12205	COG1136	(ABC) transporter
HYD28_RS12210	COG0577	efflux transmembrane transporter activity
HYD28_RS12210	COG1136	(ABC) transporter
HYD28_RS12225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HYD28_RS12235	COG2766	serine protein kinase
HYD28_RS12245	COG2719	SpoVR family
HYD28_RS12250	COG0589	response to stress
HYD28_RS12255	COG2199	diguanylate cyclase activity
HYD28_RS12260	COG2201	protein-glutamate methylesterase activity
HYD28_RS12265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYD28_RS12300	COG3219	Protein conserved in bacteria
HYD28_RS12305	COG3220	belongs to the UPF0276 family
HYD28_RS12315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYD28_RS12340	COG0848	biopolymer transport protein
HYD28_RS12345	COG0811	peptide transport
HYD28_RS12350	COG0811	peptide transport
HYD28_RS12365	COG1278	Cold shock
HYD28_RS12370	COG0418	dihydroorotase activity
HYD28_RS12375	COG5001	Diguanylate cyclase
HYD28_RS12375	COG3300	MHYT domain
HYD28_RS12380	COG1960	acyl-CoA dehydrogenase activity
HYD28_RS12400	COG1131	(ABC) transporter
HYD28_RS12410	COG0626	cystathionine gamma-synthase activity
HYD28_RS12415	COG2816	NAD+ diphosphatase activity
HYD28_RS12420	COG0363	glucosamine-6-phosphate deaminase activity
HYD28_RS12430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYD28_RS12435	COG2971	BadF BadG BcrA BcrD
HYD28_RS12455	COG0513	Belongs to the DEAD box helicase family
HYD28_RS12495	COG1801	Protein of unknown function DUF72
HYD28_RS12500	COG1451	nucleotide metabolic process
HYD28_RS12530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYD28_RS12540	COG0121	glutamine amidotransferase
HYD28_RS12545	COG1960	acyl-CoA dehydrogenase activity
HYD28_RS12575	COG0583	DNA-binding transcription factor activity
HYD28_RS12580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYD28_RS12585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYD28_RS12605	COG0402	S-adenosylhomocysteine deaminase activity
HYD28_RS12610	COG3228	Belongs to the MtfA family
HYD28_RS12615	COG3706	GGDEF domain
HYD28_RS12640	COG0494	nUDIX hydrolase
HYD28_RS12645	COG1760	l-serine dehydratase
HYD28_RS12650	COG0583	DNA-binding transcription factor activity
HYD28_RS12660	COG2252	PERMEase
HYD28_RS12715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYD28_RS12730	COG2226	methyltransferase
HYD28_RS12740	COG1388	LysM domain
HYD28_RS12740	COG0741	lytic transglycosylase activity
HYD28_RS12750	COG1166	arginine decarboxylase activity
HYD28_RS12775	COG2363	Small membrane protein
HYD28_RS12785	COG0583	DNA-binding transcription factor activity
HYD28_RS12810	COG3437	response regulator, receiver
HYD28_RS12810	COG0784	Response regulator, receiver
HYD28_RS12815	COG2890	protein-(glutamine-N5) methyltransferase activity
HYD28_RS12855	COG0012	GTP binding
HYD28_RS12910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYD28_RS12920	COG1702	phosphate starvation-inducible protein PhoH
HYD28_RS12930	COG4535	Mg2 and Co2 transporter CorC
HYD28_RS12935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYD28_RS12940	COG0545	Peptidyl-prolyl cis-trans isomerase
HYD28_RS12945	COG1067	ATP-dependent peptidase activity
HYD28_RS12970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYD28_RS12975	COG0799	negative regulation of ribosome biogenesis
HYD28_RS12985	COG0768	penicillin binding
HYD28_RS12990	COG0772	Belongs to the SEDS family
HYD28_RS12995	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYD28_RS13000	COG1686	Belongs to the peptidase S11 family
HYD28_RS13045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYD28_RS13055	COG0702	epimerase
HYD28_RS13065	COG0840	transmembrane signaling receptor activity
HYD28_RS13110	COG2885	chlorophyll binding
HYD28_RS13120	COG0814	amino acid
HYD28_RS13140	COG4771	TonB-dependent receptor
HYD28_RS13145	COG2197	response regulator
HYD28_RS13170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYD28_RS13185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYD28_RS13190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYD28_RS13200	COG1534	Rna-binding protein
HYD28_RS13215	COG3713	MltA-interacting MipA family protein
HYD28_RS13225	COG0745	RESPONSE REGULATOR receiver
HYD28_RS13230	COG2205	protein histidine kinase activity
HYD28_RS13235	COG0733	neurotransmitter:sodium symporter activity
HYD28_RS13240	COG2153	protein acetylation
HYD28_RS13245	COG4326	sporulation control protein
HYD28_RS13265	COG2205	protein histidine kinase activity
HYD28_RS13270	COG0745	RESPONSE REGULATOR receiver
HYD28_RS13285	COG3706	GGDEF domain
HYD28_RS13290	COG0583	DNA-binding transcription factor activity
HYD28_RS13315	COG2827	Endonuclease containing a URI domain
HYD28_RS13320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYD28_RS13330	COG2867	negative regulation of translational initiation
HYD28_RS13340	COG4206	TonB-dependent receptor
HYD28_RS13345	COG0450	alkyl hydroperoxide reductase
HYD28_RS13355	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYD28_RS13360	COG0287	Prephenate dehydrogenase
HYD28_RS13360	COG1605	Chorismate mutase
HYD28_RS13385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYD28_RS13390	COG4137	Cytochrome C assembly protein
HYD28_RS13395	COG4536	flavin adenine dinucleotide binding
HYD28_RS13400	COG0668	transmembrane transport
HYD28_RS13405	COG2176	DNA-directed DNA polymerase activity
HYD28_RS13415	COG5002	protein histidine kinase activity
HYD28_RS13420	COG0745	RESPONSE REGULATOR receiver
HYD28_RS13425	COG1368	sulfuric ester hydrolase activity
HYD28_RS13430	COG2194	sulfuric ester hydrolase activity
HYD28_RS13435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYD28_RS13450	COG1649	PFAM Uncharacterised BCR, COG1649
HYD28_RS13530	COG0037	tRNA processing
HYD28_RS13540	COG0587	DNA-directed DNA polymerase activity
HYD28_RS13560	COG1294	oxidase, subunit
HYD28_RS13565	COG4890	Cyd operon protein YbgT
HYD28_RS13570	COG4988	ABC transporter
HYD28_RS13575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HYD28_RS13580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYD28_RS13585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYD28_RS13610	COG0750	zinc metalloprotease
HYD28_RS13620	COG0575	Belongs to the CDS family
HYD28_RS13625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYD28_RS13630	COG0233	cytoplasmic translational termination
HYD28_RS13640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYD28_RS13650	COG0024	Methionine aminopeptidase
HYD28_RS13695	COG0626	cystathionine gamma-synthase activity
HYD28_RS13700	COG3768	UPF0283 membrane protein
HYD28_RS13705	COG3106	COG3106 Predicted ATPase
HYD28_RS13710	COG1983	PspC domain protein
HYD28_RS13720	COG1842	Phage shock protein A
HYD28_RS13725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYD28_RS13730	COG0747	negative chemotaxis
HYD28_RS13750	COG4172	Belongs to the ABC transporter superfamily
HYD28_RS13765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYD28_RS13770	COG0776	regulation of translation
HYD28_RS13775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYD28_RS13780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYD28_RS13835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYD28_RS13850	COG3852	Histidine kinase
HYD28_RS13855	COG5001	Diguanylate cyclase
HYD28_RS13855	COG4251	negative regulation of phosphorylation
HYD28_RS13855	COG3706	GGDEF domain
HYD28_RS13855	COG2203	Gaf domain
HYD28_RS13925	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HYD28_RS13925	COG3264	Mechanosensitive ion channel
HYD28_RS13935	COG0339	signal peptide processing
HYD28_RS13955	COG0583	DNA-binding transcription factor activity
HYD28_RS13960	COG0693	protein deglycase activity
HYD28_RS13980	COG0625	glutathione transferase activity
HYD28_RS14000	COG0415	Belongs to the DNA photolyase family
HYD28_RS14010	COG1764	response to oxidative stress
HYD28_RS14040	COG0589	response to stress
HYD28_RS14045	COG2814	Major facilitator Superfamily
HYD28_RS14050	COG1476	TRANSCRIPTIONal
HYD28_RS14060	COG4249	Peptidase C14 caspase catalytic subunit p20
HYD28_RS14060	COG2319	Wd-40 repeat
HYD28_RS14085	COG3706	GGDEF domain
HYD28_RS14085	COG2203	Gaf domain
HYD28_RS14085	COG4251	negative regulation of phosphorylation
HYD28_RS14085	COG5001	Diguanylate cyclase
HYD28_RS14110	COG0251	oxidation-reduction process
HYD28_RS14120	COG2239	Acts as a magnesium transporter
HYD28_RS14145	COG1620	l-lactate permease
HYD28_RS14155	COG3706	GGDEF domain
HYD28_RS14165	COG4946	Tricorn protease homolog
HYD28_RS14165	COG1506	peptidase
HYD28_RS14165	COG0823	Involved in the tonB-independent uptake of proteins
HYD28_RS14175	COG0738	Major facilitator superfamily
HYD28_RS14210	COG3447	MASE1 domain protein
HYD28_RS14210	COG5001	Diguanylate cyclase
HYD28_RS14210	COG5002	protein histidine kinase activity
HYD28_RS14215	COG0415	Belongs to the DNA photolyase family
HYD28_RS14225	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HYD28_RS14230	COG2211	Major facilitator Superfamily
HYD28_RS14280	COG3038	cytochrome b561
HYD28_RS14295	COG1125	glycine betaine transport
HYD28_RS14295	COG0517	IMP dehydrogenase activity
HYD28_RS14300	COG0783	Belongs to the Dps family
HYD28_RS14305	COG0598	Magnesium transport protein CorA
HYD28_RS14310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYD28_RS14320	COG3655	Transcriptional regulator
HYD28_RS14345	COG3655	Transcriptional regulator
HYD28_RS14365	COG5001	Diguanylate cyclase
HYD28_RS14365	COG4251	negative regulation of phosphorylation
HYD28_RS14365	COG3706	GGDEF domain
HYD28_RS14365	COG2203	Gaf domain
HYD28_RS14385	COG2207	Transcriptional regulator
HYD28_RS14395	COG3940	Belongs to the glycosyl hydrolase 43 family
HYD28_RS14420	COG0753	catalase activity
HYD28_RS14425	COG0523	cobalamin synthesis protein
HYD28_RS14445	COG1979	alcohol dehydrogenase
HYD28_RS14460	COG1335	isochorismatase
HYD28_RS14475	COG0069	glutamate synthase activity
HYD28_RS14475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HYD28_RS14510	COG2706	6-phosphogluconolactonase activity
HYD28_RS14550	COG2207	Transcriptional regulator
HYD28_RS14555	COG4773	Receptor
HYD28_RS14575	COG3344	reverse transcriptase
HYD28_RS14600	COG0583	DNA-binding transcription factor activity
HYD28_RS14605	COG4774	siderophore transport
HYD28_RS14615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYD28_RS14620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYD28_RS14625	COG0006	proline dipeptidase activity
HYD28_RS14700	COG1194	a g-specific adenine glycosylase
HYD28_RS14715	COG4191	Histidine kinase
HYD28_RS14715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYD28_RS14725	COG0745	RESPONSE REGULATOR receiver
HYD28_RS14730	COG0784	Response regulator, receiver
HYD28_RS14730	COG2198	Histidine kinase
HYD28_RS14730	COG5002	protein histidine kinase activity
HYD28_RS14750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HYD28_RS14760	COG0739	heme binding
HYD28_RS14780	COG3630	sodium ion export across plasma membrane
HYD28_RS14810	COG0527	aspartate kinase activity
HYD28_RS14820	COG2137	regulation of response to DNA damage stimulus
HYD28_RS14830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYD28_RS14840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYD28_RS14850	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HYD28_RS14865	COG2133	pyrroloquinoline quinone binding
HYD28_RS14870	COG1757	Na H antiporter
HYD28_RS14875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYD28_RS14880	COG1737	Transcriptional regulator
HYD28_RS14900	COG3876	Protein conserved in bacteria
HYD28_RS14915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYD28_RS14925	COG4948	Mandelate Racemase Muconate Lactonizing
HYD28_RS14970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYD28_RS14985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYD28_RS14995	COG0716	FMN binding
HYD28_RS15015	COG0513	Belongs to the DEAD box helicase family
HYD28_RS15040	COG0560	Phosphoserine phosphatase
HYD28_RS15050	COG0084	hydrolase, TatD family'
HYD28_RS15070	COG2205	protein histidine kinase activity
HYD28_RS15070	COG0784	Response regulator, receiver
HYD28_RS15075	COG0456	acetyltransferase
HYD28_RS15095	COG0517	IMP dehydrogenase activity
HYD28_RS15095	COG0516	GMP reductase activity
HYD28_RS15110	COG1045	serine acetyltransferase
HYD28_RS15125	COG2203	Gaf domain
HYD28_RS15125	COG3706	GGDEF domain
HYD28_RS15125	COG4251	negative regulation of phosphorylation
HYD28_RS15125	COG5001	Diguanylate cyclase
HYD28_RS15130	COG0612	Peptidase, M16
HYD28_RS15140	COG2199	diguanylate cyclase activity
HYD28_RS15140	COG2203	Gaf domain
HYD28_RS15145	COG0513	Belongs to the DEAD box helicase family
HYD28_RS15160	COG0745	RESPONSE REGULATOR receiver
HYD28_RS15190	COG3706	GGDEF domain
HYD28_RS15220	COG0745	RESPONSE REGULATOR receiver
HYD28_RS15225	COG2205	protein histidine kinase activity
HYD28_RS15245	COG2204	response regulator
HYD28_RS15255	COG2205	protein histidine kinase activity
HYD28_RS15280	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYD28_RS15325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYD28_RS15345	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HYD28_RS15350	COG2943	transferase activity, transferring hexosyl groups
HYD28_RS15360	COG5002	protein histidine kinase activity
HYD28_RS15365	COG0745	RESPONSE REGULATOR receiver
HYD28_RS15400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYD28_RS15400	COG0517	IMP dehydrogenase activity
HYD28_RS15405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYD28_RS15415	COG2205	protein histidine kinase activity
HYD28_RS15415	COG0784	Response regulator, receiver
HYD28_RS15430	COG0788	formyltetrahydrofolate deformylase activity
HYD28_RS15450	COG4773	Receptor
HYD28_RS15480	COG1238	metal cluster binding
HYD28_RS15530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYD28_RS15565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYD28_RS15575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYD28_RS15590	COG3025	triphosphatase activity
HYD28_RS15605	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HYD28_RS15605	COG0506	proline dehydrogenase activity
HYD28_RS15605	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HYD28_RS15620	COG3267	Type II secretory pathway component ExeA
HYD28_RS15620	COG3409	Peptidoglycan-binding domain 1 protein
HYD28_RS15655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYD28_RS15660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYD28_RS15665	COG4206	TonB-dependent receptor
HYD28_RS15690	COG0301	tRNA thio-modification
HYD28_RS15690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYD28_RS15750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYD28_RS15760	COG0076	glutamate decarboxylase activity
HYD28_RS15765	COG2199	diguanylate cyclase activity
HYD28_RS15765	COG2200	EAL domain
HYD28_RS15765	COG3287	FIST C domain
HYD28_RS15770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYD28_RS15775	COG0842	Transport permease protein
HYD28_RS15780	COG1131	(ABC) transporter
HYD28_RS15785	COG0163	prenyltransferase activity
HYD28_RS15790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYD28_RS15805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYD28_RS15835	COG3437	response regulator, receiver
HYD28_RS15835	COG0784	Response regulator, receiver
HYD28_RS15860	COG1580	Controls the rotational direction of flagella during chemotaxis
HYD28_RS15865	COG0705	Rhomboid family
HYD28_RS15890	COG0859	PFAM glycosyl transferase family 9
HYD28_RS15895	COG3642	lipopolysaccharide core region biosynthetic process
HYD28_RS15905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HYD28_RS15915	COG1519	Transferase
HYD28_RS15925	COG3784	Protein of unknown function (DUF1318)
HYD28_RS15965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYD28_RS15980	COG2177	Part of the ABC transporter FtsEX involved in
HYD28_RS15985	COG2884	Cell division ATP-binding protein ftsE
HYD28_RS15990	COG0552	protein localization to endoplasmic reticulum
HYD28_RS15995	COG0742	ribosomal rna small subunit methyltransferase
HYD28_RS16025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYD28_RS16030	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HYD28_RS16045	COG0151	Belongs to the GarS family
HYD28_RS16050	COG2200	EAL domain
HYD28_RS16050	COG2199	diguanylate cyclase activity
HYD28_RS16050	COG2203	Gaf domain
HYD28_RS16070	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYD28_RS16085	COG1280	lysine exporter protein (LysE YggA)
HYD28_RS16110	COG0823	Involved in the tonB-independent uptake of proteins
HYD28_RS16125	COG1187	pseudouridine synthase activity
HYD28_RS16130	COG0840	transmembrane signaling receptor activity
HYD28_RS16160	COG4771	TonB-dependent receptor
HYD28_RS16165	COG0457	Tetratricopeptide repeat
HYD28_RS16170	COG2897	thiosulfate sulfurtransferase activity
HYD28_RS16175	COG3562	capsule polysaccharide
HYD28_RS16180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYD28_RS16200	COG5001	Diguanylate cyclase
HYD28_RS16200	COG3300	MHYT domain
HYD28_RS16210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYD28_RS16220	COG1136	(ABC) transporter
HYD28_RS16250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYD28_RS16260	COG1227	inorganic diphosphatase activity
HYD28_RS16265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYD28_RS16270	COG0557	exoribonuclease II activity
HYD28_RS16285	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYD28_RS16295	COG0584	glycerophosphoryl diester phosphodiesterase
HYD28_RS16315	COG2202	Pas domain
HYD28_RS16315	COG2205	protein histidine kinase activity
HYD28_RS16320	COG1247	-acetyltransferase
HYD28_RS16335	COG0625	glutathione transferase activity
HYD28_RS16365	COG3954	Phosphoribulokinase
HYD28_RS16370	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HYD28_RS16375	COG1011	Hydrolase
HYD28_RS16385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYD28_RS16390	COG0849	cell division
HYD28_RS16395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYD28_RS16430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYD28_RS16435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYD28_RS16440	COG0768	penicillin binding
HYD28_RS16445	COG3116	cell division
HYD28_RS16480	COG0435	Glutathione S-transferase
HYD28_RS16485	COG1741	Belongs to the pirin family
HYD28_RS16490	COG1295	ribonuclease BN
HYD28_RS16500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYD28_RS16510	COG1349	DNA-binding transcription factor activity
HYD28_RS16515	COG0738	Major facilitator superfamily
HYD28_RS16535	COG1940	carbohydrate kinase activity
HYD28_RS16540	COG2222	sugar isomerase
HYD28_RS16550	COG0673	inositol 2-dehydrogenase activity
HYD28_RS16560	COG3591	Belongs to the peptidase S1B family
HYD28_RS16560	COG4990	cell redox homeostasis
HYD28_RS16570	COG2197	response regulator
HYD28_RS16590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA