locus-tag	class	description
IT970_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT970_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
IT970_RS00030	COG0751	glycine-tRNA ligase activity
IT970_RS00040	COG0425	Belongs to the sulfur carrier protein TusA family
IT970_RS00045	COG0183	Belongs to the thiolase family
IT970_RS00050	COG1024	Enoyl-CoA hydratase
IT970_RS00050	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT970_RS00055	COG0741	lytic transglycosylase activity
IT970_RS00060	COG0006	proline dipeptidase activity
IT970_RS00065	COG1739	Uncharacterized protein family UPF0029
IT970_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT970_RS00100	COG0569	domain protein
IT970_RS00110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IT970_RS00115	COG0242	peptide deformylase activity
IT970_RS00125	COG0758	DNA mediated transformation
IT970_RS00130	COG2922	Belongs to the Smg family
IT970_RS00140	COG0009	L-threonylcarbamoyladenylate synthase
IT970_RS00145	COG0408	coproporphyrinogen oxidase activity
IT970_RS00155	COG0840	transmembrane signaling receptor activity
IT970_RS00160	COG2346	COG2346, Truncated hemoglobins
IT970_RS00165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT970_RS00175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT970_RS00225	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IT970_RS00295	COG1522	sequence-specific DNA binding
IT970_RS00305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT970_RS00340	COG1597	lipid kinase activity
IT970_RS00350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT970_RS00365	COG0386	Belongs to the glutathione peroxidase family
IT970_RS00370	COG0583	DNA-binding transcription factor activity
IT970_RS00375	COG1979	alcohol dehydrogenase
IT970_RS00385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IT970_RS00405	COG1404	Belongs to the peptidase S8 family
IT970_RS00410	COG1770	oligopeptidase
IT970_RS00415	COG0784	Response regulator, receiver
IT970_RS00415	COG2205	protein histidine kinase activity
IT970_RS00415	COG5002	protein histidine kinase activity
IT970_RS00420	COG0745	RESPONSE REGULATOR receiver
IT970_RS00445	COG1238	metal cluster binding
IT970_RS00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT970_RS00455	COG0302	gtp cyclohydrolase
IT970_RS00470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IT970_RS00475	COG3132	Protein of unknown function, DUF480
IT970_RS00480	COG0784	Response regulator, receiver
IT970_RS00480	COG5002	protein histidine kinase activity
IT970_RS00480	COG2205	protein histidine kinase activity
IT970_RS00495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT970_RS00495	COG3153	acetyltransferase
IT970_RS00525	COG1187	pseudouridine synthase activity
IT970_RS00550	COG1011	Hydrolase
IT970_RS00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IT970_RS00565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT970_RS00570	COG0019	diaminopimelate decarboxylase activity
IT970_RS00580	COG1965	Belongs to the frataxin family
IT970_RS00585	COG0400	carboxylic ester hydrolase activity
IT970_RS00595	COG0181	hydroxymethylbilane synthase activity
IT970_RS00615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT970_RS00620	COG4109	DRTGG domain
IT970_RS00630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IT970_RS00640	COG2354	Protein conserved in bacteria
IT970_RS00650	COG0513	Belongs to the DEAD box helicase family
IT970_RS00660	COG2205	protein histidine kinase activity
IT970_RS00660	COG2198	Histidine kinase
IT970_RS00660	COG0784	Response regulator, receiver
IT970_RS00660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT970_RS00675	COG3118	belongs to the thioredoxin family
IT970_RS00680	COG0513	Belongs to the DEAD box helicase family
IT970_RS00685	COG0248	Ppx GppA phosphatase
IT970_RS00715	COG1444	tRNA N-acetyltransferase activity
IT970_RS00720	COG0210	DNA helicase
IT970_RS00730	COG3112	Uncharacterised protein family (UPF0231)
IT970_RS00745	COG0756	dUTP diphosphatase activity
IT970_RS00760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT970_RS00780	COG3093	addiction module antidote protein HigA
IT970_RS00825	COG1011	Hydrolase
IT970_RS00830	COG0494	nUDIX hydrolase
IT970_RS00835	COG1218	3'(2'),5'-bisphosphate nucleotidase
IT970_RS00855	COG0745	RESPONSE REGULATOR receiver
IT970_RS00855	COG2205	protein histidine kinase activity
IT970_RS00855	COG3292	Two component regulator propeller
IT970_RS00875	COG0606	chelatase, subunit chli
IT970_RS00890	COG1253	flavin adenine dinucleotide binding
IT970_RS00905	COG2031	fatty acid transporter
IT970_RS00910	COG0784	Response regulator, receiver
IT970_RS00910	COG0835	chemotaxis
IT970_RS00935	COG1946	Acyl-CoA thioesterase
IT970_RS00940	COG2937	Belongs to the GPAT DAPAT family
IT970_RS00945	COG0051	transcription antitermination factor activity, RNA binding
IT970_RS00950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IT970_RS00955	COG0088	Forms part of the polypeptide exit tunnel
IT970_RS00960	COG0089	rRNA binding
IT970_RS00965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IT970_RS00970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT970_RS00975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IT970_RS00980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IT970_RS00985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT970_RS00990	COG0255	Belongs to the universal ribosomal protein uL29 family
IT970_RS00995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IT970_RS01020	COG2356	endonuclease I
IT970_RS01030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT970_RS01035	COG0175	sulfate reduction
IT970_RS01095	COG2204	response regulator
IT970_RS01100	COG3852	Histidine kinase
IT970_RS01110	COG0174	glutamine synthetase
IT970_RS01115	COG1217	gtp-binding protein TYPA
IT970_RS01125	COG1959	2 iron, 2 sulfur cluster binding
IT970_RS01135	COG3256	nitric oxide reductase
IT970_RS01150	COG1295	ribonuclease BN
IT970_RS01160	COG1490	D-aminoacyl-tRNA deacylase activity
IT970_RS01170	COG0456	acetyltransferase
IT970_RS01185	COG0019	diaminopimelate decarboxylase activity
IT970_RS01195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT970_RS01205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IT970_RS01210	COG2885	chlorophyll binding
IT970_RS01215	COG1049	propionate catabolic process, 2-methylcitrate cycle
IT970_RS01230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT970_RS01235	COG1082	Xylose isomerase domain protein TIM barrel
IT970_RS01245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IT970_RS01250	COG1166	arginine decarboxylase activity
IT970_RS01255	COG0204	Acyl-transferase
IT970_RS01260	COG0204	Acyl-transferase
IT970_RS01265	COG0668	transmembrane transport
IT970_RS01285	COG1132	(ABC) transporter
IT970_RS01325	COG0640	Transcriptional regulator
IT970_RS01355	COG3021	interspecies interaction between organisms
IT970_RS01360	COG0577	efflux transmembrane transporter activity
IT970_RS01365	COG1136	(ABC) transporter
IT970_RS01370	COG1566	PFAM secretion protein HlyD family protein
IT970_RS01380	COG4989	oxidoreductase activity
IT970_RS01410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IT970_RS01415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IT970_RS01420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IT970_RS01425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IT970_RS01430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IT970_RS01435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IT970_RS01440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IT970_RS01445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IT970_RS01450	COG1841	ribosomal large subunit assembly
IT970_RS01455	COG0200	Binds to the 23S rRNA
IT970_RS01460	COG0201	protein transport
IT970_RS01465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IT970_RS01470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IT970_RS01475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IT970_RS01480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IT970_RS01485	COG0202	RNA polymerase activity
IT970_RS01490	COG0203	ribosomal protein L17
IT970_RS01510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IT970_RS01515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IT970_RS01520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IT970_RS01525	COG3031	protein transport across the cell outer membrane
IT970_RS01535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IT970_RS01540	COG1459	type II secretion system
IT970_RS01545	COG2165	general secretion pathway protein
IT970_RS01555	COG2165	general secretion pathway protein
IT970_RS01605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IT970_RS01615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT970_RS01620	COG1683	Conserved Protein
IT970_RS01625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IT970_RS01635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IT970_RS01640	COG0724	RNA recognition motif
IT970_RS01670	COG0814	amino acid
IT970_RS01680	COG1218	3'(2'),5'-bisphosphate nucleotidase
IT970_RS01685	COG0529	Catalyzes the synthesis of activated sulfate
IT970_RS01690	COG3273	potassium ion transport
IT970_RS01690	COG0471	metal ion transport
IT970_RS01695	COG2895	sulfate adenylyltransferase (ATP) activity
IT970_RS01700	COG0175	sulfate reduction
IT970_RS01705	COG1648	precorrin-2 dehydrogenase activity
IT970_RS01705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT970_RS01710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IT970_RS01725	COG3292	Two component regulator propeller
IT970_RS01725	COG3292	Two component regulator propeller
IT970_RS01725	COG2205	protein histidine kinase activity
IT970_RS01725	COG0745	RESPONSE REGULATOR receiver
IT970_RS01725	COG2205	protein histidine kinase activity
IT970_RS01725	COG0745	RESPONSE REGULATOR receiver
IT970_RS01735	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT970_RS01740	COG0250	Participates in transcription elongation, termination and antitermination
IT970_RS01745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IT970_RS01750	COG0081	regulation of translation
IT970_RS01755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IT970_RS01760	COG0222	ribosome binding
IT970_RS01765	COG0085	RNA polymerase activity
IT970_RS01770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IT970_RS01775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IT970_RS01780	COG0049	tRNA binding
IT970_RS01785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT970_RS01790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT970_RS01800	COG1785	Belongs to the alkaline phosphatase family
IT970_RS01825	COG0784	Response regulator, receiver
IT970_RS01825	COG2205	protein histidine kinase activity
IT970_RS01835	COG1119	ATPase activity
IT970_RS01855	COG0129	dihydroxy-acid dehydratase activity
IT970_RS01860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT970_RS01875	COG0288	reversible hydration of carbon dioxide
IT970_RS01885	COG0210	DNA helicase
IT970_RS01900	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IT970_RS01905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT970_RS01905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT970_RS01920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IT970_RS01950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IT970_RS01975	COG1509	lysine 2,3-aminomutase activity
IT970_RS01980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT970_RS01985	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IT970_RS01990	COG4774	siderophore transport
IT970_RS01990	COG1629	transport
IT970_RS02005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IT970_RS02020	COG2022	thiamine diphosphate biosynthetic process
IT970_RS02025	COG0352	thiamine-phosphate diphosphorylase activity
IT970_RS02030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT970_RS02035	COG0688	phosphatidylethanolamine metabolic process
IT970_RS02040	COG1162	GTPase activity
IT970_RS02045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IT970_RS02070	COG0432	Pfam Uncharacterised protein family UPF0047
IT970_RS02080	COG0735	belongs to the Fur family
IT970_RS02085	COG2095	MarC family integral membrane protein
IT970_RS02100	COG1842	Phage shock protein A
IT970_RS02145	COG1032	radical SAM domain protein
IT970_RS02150	COG2239	Acts as a magnesium transporter
IT970_RS02155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT970_RS02160	COG1660	Displays ATPase and GTPase activities
IT970_RS02165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT970_RS02170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT970_RS02175	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IT970_RS02180	COG1137	ATPase activity
IT970_RS02195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IT970_RS02200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IT970_RS02200	COG0517	IMP dehydrogenase activity
IT970_RS02210	COG1127	ABC transporter
IT970_RS02215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IT970_RS02220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT970_RS02225	COG2854	intermembrane phospholipid transfer
IT970_RS02230	COG3113	response to antibiotic
IT970_RS02235	COG5007	Belongs to the BolA IbaG family
IT970_RS02240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IT970_RS02250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT970_RS02260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT970_RS02265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IT970_RS02270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IT970_RS02275	COG0723	plastoquinol--plastocyanin reductase activity
IT970_RS02280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IT970_RS02285	COG2857	Cytochrome c1
IT970_RS02290	COG0625	glutathione transferase activity
IT970_RS02295	COG2969	positive regulation of protein catabolic process
IT970_RS02300	COG2823	Periplasmic or secreted lipoprotein
IT970_RS02310	COG0792	nuclease activity
IT970_RS02320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IT970_RS02340	COG0673	inositol 2-dehydrogenase activity
IT970_RS02350	COG1295	ribonuclease BN
IT970_RS02355	COG1741	Belongs to the pirin family
IT970_RS02360	COG0435	Glutathione S-transferase
IT970_RS02385	COG2001	Belongs to the MraZ family
IT970_RS02390	COG0275	rRNA processing
IT970_RS02395	COG3116	cell division
IT970_RS02400	COG0768	penicillin binding
IT970_RS02405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT970_RS02410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IT970_RS02415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT970_RS02420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IT970_RS02425	COG0772	Belongs to the SEDS family
IT970_RS02430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IT970_RS02435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT970_RS02440	COG1181	Belongs to the D-alanine--D-alanine ligase family
IT970_RS02445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IT970_RS02450	COG0849	cell division
IT970_RS02455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IT970_RS02460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IT970_RS02465	COG1011	Hydrolase
IT970_RS02470	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IT970_RS02475	COG3954	Phosphoribulokinase
IT970_RS02505	COG0625	glutathione transferase activity
IT970_RS02520	COG1247	-acetyltransferase
IT970_RS02525	COG2205	protein histidine kinase activity
IT970_RS02525	COG2202	Pas domain
IT970_RS02545	COG0584	glycerophosphoryl diester phosphodiesterase
IT970_RS02555	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IT970_RS02570	COG0557	exoribonuclease II activity
IT970_RS02575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT970_RS02580	COG1227	inorganic diphosphatase activity
IT970_RS02605	COG3842	ATPase activity
IT970_RS02615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT970_RS02620	COG0859	PFAM glycosyl transferase family 9
IT970_RS02625	COG3306	glycosyltransferase involved in LPS biosynthesis
IT970_RS02635	COG0457	Tetratricopeptide repeat
IT970_RS02640	COG4771	TonB-dependent receptor
IT970_RS02655	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IT970_RS02670	COG0840	transmembrane signaling receptor activity
IT970_RS02675	COG1187	pseudouridine synthase activity
IT970_RS02680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT970_RS02690	COG0745	RESPONSE REGULATOR receiver
IT970_RS02720	COG1280	lysine exporter protein (LysE YggA)
IT970_RS02735	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT970_RS02760	COG0151	Belongs to the GarS family
IT970_RS02770	COG0138	bifunctional purine biosynthesis protein purh
IT970_RS02775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IT970_RS02780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT970_RS02785	COG2264	protein methyltransferase activity
IT970_RS02805	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IT970_RS02810	COG0742	ribosomal rna small subunit methyltransferase
IT970_RS02815	COG0552	protein localization to endoplasmic reticulum
IT970_RS02820	COG2884	Cell division ATP-binding protein ftsE
IT970_RS02825	COG2177	Part of the ABC transporter FtsEX involved in
IT970_RS02835	COG2066	Belongs to the glutaminase family
IT970_RS02840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT970_RS02855	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IT970_RS02860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT970_RS02860	COG0047	phosphoribosylformylglycinamidine synthase activity
IT970_RS02875	COG3784	Protein of unknown function (DUF1318)
IT970_RS02885	COG1519	Transferase
IT970_RS02895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IT970_RS02900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IT970_RS02900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IT970_RS02905	COG3642	lipopolysaccharide core region biosynthetic process
IT970_RS02910	COG0859	PFAM glycosyl transferase family 9
IT970_RS02925	COG1063	alcohol dehydrogenase
IT970_RS02930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT970_RS02935	COG0705	Rhomboid family
IT970_RS02940	COG1580	Controls the rotational direction of flagella during chemotaxis
IT970_RS02945	COG3161	chorismate lyase activity
IT970_RS02950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IT970_RS02965	COG3437	response regulator, receiver
IT970_RS02965	COG0784	Response regulator, receiver
IT970_RS02985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IT970_RS02990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IT970_RS03005	COG1968	undecaprenyl-diphosphatase activity
IT970_RS03010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT970_RS03015	COG0163	prenyltransferase activity
IT970_RS03020	COG1131	(ABC) transporter
IT970_RS03025	COG0842	Transport permease protein
IT970_RS03030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT970_RS03035	COG2200	EAL domain
IT970_RS03040	COG0076	glutamate decarboxylase activity
IT970_RS03050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IT970_RS03065	COG0137	argininosuccinate synthase activity
IT970_RS03070	COG0165	Argininosuccinate lyase
IT970_RS03100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IT970_RS03110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT970_RS03110	COG0301	tRNA thio-modification
IT970_RS03115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IT970_RS03125	COG1666	GTP binding
IT970_RS03130	COG4206	TonB-dependent receptor
IT970_RS03135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT970_RS03140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT970_RS03175	COG3267	Type II secretory pathway component ExeA
IT970_RS03175	COG3409	Peptidoglycan-binding domain 1 protein
IT970_RS03190	COG0506	proline dehydrogenase activity
IT970_RS03190	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IT970_RS03190	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IT970_RS03200	COG4991	sh3 domain protein
IT970_RS03205	COG3025	triphosphatase activity
IT970_RS03215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IT970_RS03220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IT970_RS03225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT970_RS03230	COG3123	guanosine phosphorylase activity
IT970_RS03275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT970_RS03365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IT970_RS03370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IT970_RS03375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IT970_RS03380	COG0585	pseudouridine synthase activity
IT970_RS03385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IT970_RS03390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT970_RS03395	COG1238	metal cluster binding
IT970_RS03400	COG4942	peptidase
IT970_RS03400	COG1388	LysM domain
IT970_RS03410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IT970_RS03425	COG4773	Receptor
IT970_RS03435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT970_RS03445	COG0788	formyltetrahydrofolate deformylase activity
IT970_RS03455	COG0784	Response regulator, receiver
IT970_RS03455	COG2205	protein histidine kinase activity
IT970_RS03465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT970_RS03470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IT970_RS03470	COG0517	IMP dehydrogenase activity
IT970_RS03485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT970_RS03490	COG0126	phosphoglycerate kinase activity
IT970_RS03505	COG0745	RESPONSE REGULATOR receiver
IT970_RS03510	COG5002	protein histidine kinase activity
IT970_RS03535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IT970_RS03540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IT970_RS03545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IT970_RS03555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT970_RS03575	COG1489	DNA binding
IT970_RS03580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT970_RS03630	COG2205	protein histidine kinase activity
IT970_RS03640	COG2204	response regulator
IT970_RS03660	COG0642	Histidine kinase
IT970_RS03665	COG0745	RESPONSE REGULATOR receiver
IT970_RS03690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IT970_RS03705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT970_RS03715	COG1404	Belongs to the peptidase S8 family
IT970_RS03730	COG0745	RESPONSE REGULATOR receiver
IT970_RS03745	COG0513	Belongs to the DEAD box helicase family
IT970_RS03755	COG0612	Peptidase, M16
IT970_RS03760	COG3706	GGDEF domain
IT970_RS03760	COG2203	Gaf domain
IT970_RS03760	COG5001	Diguanylate cyclase
IT970_RS03760	COG4251	negative regulation of phosphorylation
IT970_RS03780	COG1045	serine acetyltransferase
IT970_RS03790	COG1570	exodeoxyribonuclease VII activity
IT970_RS03795	COG0516	GMP reductase activity
IT970_RS03795	COG0517	IMP dehydrogenase activity
IT970_RS03800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT970_RS03800	COG0519	Catalyzes the synthesis of GMP from XMP
IT970_RS03815	COG0456	acetyltransferase
IT970_RS03820	COG0784	Response regulator, receiver
IT970_RS03820	COG2205	protein histidine kinase activity
IT970_RS03825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IT970_RS03830	COG0018	arginyl-trna synthetase
IT970_RS03835	COG0259	pyridoxamine-phosphate oxidase activity
IT970_RS03840	COG0084	hydrolase, TatD family'
IT970_RS03850	COG0560	Phosphoserine phosphatase
IT970_RS03875	COG0513	Belongs to the DEAD box helicase family
IT970_RS03880	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IT970_RS03900	COG0716	FMN binding
IT970_RS03910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT970_RS03925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IT970_RS03960	COG2267	carboxylic ester hydrolase activity
IT970_RS03990	COG4948	Mandelate Racemase Muconate Lactonizing
IT970_RS04000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT970_RS04015	COG3876	Protein conserved in bacteria
IT970_RS04030	COG1737	Transcriptional regulator
IT970_RS04035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT970_RS04040	COG1757	Na H antiporter
IT970_RS04045	COG2133	pyrroloquinoline quinone binding
IT970_RS04060	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IT970_RS04070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT970_RS04080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT970_RS04090	COG2137	regulation of response to DNA damage stimulus
IT970_RS04095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT970_RS04100	COG0527	aspartate kinase activity
IT970_RS04105	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IT970_RS04135	COG3630	sodium ion export across plasma membrane
IT970_RS04140	COG0511	ligase activity, forming carbon-carbon bonds
IT970_RS04140	COG5016	pyruvate
IT970_RS04155	COG0739	heme binding
IT970_RS04160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IT970_RS04170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT970_RS04180	COG1469	GTP cyclohydrolase I activity
IT970_RS04185	COG2198	Histidine kinase
IT970_RS04185	COG5002	protein histidine kinase activity
IT970_RS04185	COG0784	Response regulator, receiver
IT970_RS04190	COG0745	RESPONSE REGULATOR receiver
IT970_RS04200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT970_RS04200	COG4191	Histidine kinase
IT970_RS04205	COG2813	Specifically methylates the guanine in position
IT970_RS04210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT970_RS04215	COG1194	a g-specific adenine glycosylase
IT970_RS04220	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IT970_RS04265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT970_RS04280	COG0006	proline dipeptidase activity
IT970_RS04285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT970_RS04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT970_RS04300	COG3066	DNA modification
IT970_RS04305	COG1051	belongs to the nudix hydrolase family
IT970_RS04315	COG0730	response to heat
IT970_RS04320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IT970_RS04325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IT970_RS04330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IT970_RS04370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT970_RS04375	COG1063	alcohol dehydrogenase
IT970_RS04380	COG2207	Transcriptional regulator
IT970_RS04390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT970_RS04390	COG0678	peroxiredoxin activity
IT970_RS04395	COG0583	DNA-binding transcription factor activity
IT970_RS04415	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IT970_RS04420	COG2197	response regulator
IT970_RS04425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT970_RS04455	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IT970_RS04460	COG0784	Response regulator, receiver
IT970_RS04460	COG0835	chemotaxis
IT970_RS04465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IT970_RS04470	COG1815	bacterial-type flagellum-dependent cell motility
IT970_RS04490	COG4787	bacterial-type flagellum-dependent cell motility
IT970_RS04495	COG4786	Flagellar basal body rod
IT970_RS04500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IT970_RS04505	COG1706	bacterial-type flagellum-dependent cell motility
IT970_RS04510	COG1705	Flagellar rod assembly protein muramidase FlgJ
IT970_RS04510	COG3951	Flagellar rod assembly protein muramidase FlgJ
IT970_RS04550	COG1516	flagellar protein fliS
IT970_RS04575	COG0519	Catalyzes the synthesis of GMP from XMP
IT970_RS04590	COG1677	Flagellar hook-basal body complex protein FliE
IT970_RS04595	COG1766	The M ring may be actively involved in energy transduction
IT970_RS04600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT970_RS04620	COG3144	bacterial-type flagellum assembly
IT970_RS04640	COG3190	flagellar
IT970_RS04650	COG1987	bacterial-type flagellum assembly
IT970_RS04665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT970_RS04690	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IT970_RS04695	COG0643	Histidine kinase
IT970_RS04695	COG2198	Histidine kinase
IT970_RS04695	COG0784	Response regulator, receiver
IT970_RS04700	COG2201	protein-glutamate methylesterase activity
IT970_RS04705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT970_RS04715	COG1192	Involved in chromosome partitioning
IT970_RS04725	COG0835	chemotaxis
IT970_RS04745	COG4133	protoheme IX ABC transporter activity
IT970_RS04750	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT970_RS04755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT970_RS04760	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT970_RS04765	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IT970_RS04770	COG1138	Cytochrome C-type biogenesis protein
IT970_RS04795	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IT970_RS04800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT970_RS04805	COG3141	response to X-ray
IT970_RS04820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IT970_RS04825	COG0077	Prephenate dehydratase
IT970_RS04825	COG1605	Chorismate mutase
IT970_RS04835	COG0023	Translation Initiation Factor
IT970_RS04860	COG1448	Aminotransferase
IT970_RS04885	COG2304	oxidoreductase activity
IT970_RS04900	COG0714	Associated with various cellular activities
IT970_RS04905	COG0183	Belongs to the thiolase family
IT970_RS04910	COG1024	Enoyl-CoA hydratase
IT970_RS04910	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT970_RS04920	COG2315	Protein conserved in bacteria
IT970_RS04925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT970_RS04950	COG0714	Associated with various cellular activities
IT970_RS04970	COG3300	MHYT domain
IT970_RS04970	COG5001	Diguanylate cyclase
IT970_RS04975	COG1025	Belongs to the peptidase M16 family
IT970_RS04980	COG2062	phosphohistidine phosphatase, SixA
IT970_RS04985	COG0251	oxidation-reduction process
IT970_RS04995	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS05005	COG2840	Smr protein MutS2
IT970_RS05010	COG2890	protein-(glutamine-N5) methyltransferase activity
IT970_RS05015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IT970_RS05030	COG0583	DNA-binding transcription factor activity
IT970_RS05045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IT970_RS05050	COG3101	peptidyl-lysine hydroxylation
IT970_RS05065	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IT970_RS05090	COG0071	Belongs to the small heat shock protein (HSP20) family
IT970_RS05095	COG3046	protein related to deoxyribodipyrimidine photolyase
IT970_RS05110	COG0779	Required for maturation of 30S ribosomal subunits
IT970_RS05115	COG0195	Participates in both transcription termination and antitermination
IT970_RS05120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IT970_RS05125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IT970_RS05130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IT970_RS05135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IT970_RS05140	COG1185	polyribonucleotide nucleotidyltransferase activity
IT970_RS05155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT970_RS05155	COG2111	Na H antiporter
IT970_RS05160	COG1006	Multisubunit Na H antiporter MnhC subunit
IT970_RS05165	COG0651	ATP synthesis coupled electron transport
IT970_RS05170	COG1863	multisubunit Na H antiporter MnhE subunit
IT970_RS05175	COG2212	antiporter activity
IT970_RS05180	COG1320	monovalent cation:proton antiporter activity
IT970_RS05185	COG0101	tRNA pseudouridine synthase activity
IT970_RS05190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IT970_RS05195	COG0285	dihydrofolate synthase activity
IT970_RS05205	COG1286	toxin biosynthetic process
IT970_RS05210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IT970_RS05235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IT970_RS05240	COG0215	cysteine-tRNA ligase activity
IT970_RS05245	COG0697	spore germination
IT970_RS05250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT970_RS05280	COG0544	peptidyl-prolyl cis-trans isomerase activity
IT970_RS05285	COG0740	serine-type endopeptidase activity
IT970_RS05290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IT970_RS05295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT970_RS05300	COG0776	regulation of translation
IT970_RS05305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT970_RS05310	COG4172	Belongs to the ABC transporter superfamily
IT970_RS05315	COG4172	Belongs to the ABC transporter superfamily
IT970_RS05330	COG0747	negative chemotaxis
IT970_RS05335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IT970_RS05340	COG1842	Phage shock protein A
IT970_RS05350	COG1983	PspC domain protein
IT970_RS05355	COG3106	COG3106 Predicted ATPase
IT970_RS05360	COG3768	UPF0283 membrane protein
IT970_RS05365	COG0626	cystathionine gamma-synthase activity
IT970_RS05375	COG2154	pterin-4-alpha-carbinolamine dehydratase
IT970_RS05385	COG0840	transmembrane signaling receptor activity
IT970_RS05400	COG2171	N-acyltransferase activity
IT970_RS05405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IT970_RS05410	COG0024	Methionine aminopeptidase
IT970_RS05415	COG0052	Belongs to the universal ribosomal protein uS2 family
IT970_RS05420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IT970_RS05425	COG0528	UMP kinase activity
IT970_RS05430	COG0233	cytoplasmic translational termination
IT970_RS05435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT970_RS05440	COG0575	Belongs to the CDS family
IT970_RS05450	COG0750	zinc metalloprotease
IT970_RS05465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT970_RS05470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT970_RS05475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT970_RS05480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IT970_RS05485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IT970_RS05490	COG4988	ABC transporter
IT970_RS05495	COG4890	Cyd operon protein YbgT
IT970_RS05500	COG1294	oxidase, subunit
IT970_RS05510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT970_RS05515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IT970_RS05520	COG0587	DNA-directed DNA polymerase activity
IT970_RS05525	COG0825	malonyl-CoA metabolic process
IT970_RS05530	COG0037	tRNA processing
IT970_RS05565	COG1629	transport
IT970_RS05575	COG2814	Major facilitator Superfamily
IT970_RS05575	COG0477	Major facilitator Superfamily
IT970_RS05580	COG1621	beta-fructofuranosidase activity
IT970_RS05595	COG3038	cytochrome b561
IT970_RS05600	COG0366	Alpha amylase catalytic
IT970_RS05615	COG1649	PFAM Uncharacterised BCR, COG1649
IT970_RS05635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IT970_RS05640	COG2194	sulfuric ester hydrolase activity
IT970_RS05645	COG1368	sulfuric ester hydrolase activity
IT970_RS05650	COG0745	RESPONSE REGULATOR receiver
IT970_RS05655	COG5002	protein histidine kinase activity
IT970_RS05670	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IT970_RS05675	COG0602	queuosine metabolic process
IT970_RS05680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IT970_RS05685	COG2716	regulation of RNA biosynthetic process
IT970_RS05695	COG3314	Sporulation integral membrane protein YlbJ
IT970_RS05705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IT970_RS05710	COG2854	intermembrane phospholipid transfer
IT970_RS05730	COG1393	Belongs to the ArsC family
IT970_RS05750	COG1104	cysteine desulfurase activity
IT970_RS05755	COG1609	Transcriptional regulator
IT970_RS05760	COG0166	Belongs to the GPI family
IT970_RS05765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IT970_RS05770	COG0363	glucosamine-6-phosphate deaminase activity
IT970_RS05795	COG1446	asparaginase
IT970_RS05800	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT970_RS05800	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT970_RS05810	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IT970_RS05840	COG3098	single-species biofilm formation
IT970_RS05845	COG0564	pseudouridine synthase activity
IT970_RS05855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT970_RS05860	COG1196	nuclear chromosome segregation
IT970_RS05865	COG3115	cell septum assembly
IT970_RS05870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT970_RS05890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT970_RS05895	COG2198	Histidine kinase
IT970_RS05895	COG5002	protein histidine kinase activity
IT970_RS05895	COG0784	Response regulator, receiver
IT970_RS05900	COG1653	transport
IT970_RS05990	COG3547	Transposase (IS116 IS110 IS902 family)
IT970_RS06000	COG2205	protein histidine kinase activity
IT970_RS06000	COG0784	Response regulator, receiver
IT970_RS06005	COG0346	lactoylglutathione lyase activity
IT970_RS06015	COG1982	Orn Lys Arg decarboxylase major
IT970_RS06025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IT970_RS06030	COG4660	Part of a membrane complex involved in electron transport
IT970_RS06035	COG4659	FMN binding
IT970_RS06040	COG4658	electron transport chain
IT970_RS06045	COG4656	Part of a membrane complex involved in electron transport
IT970_RS06050	COG2878	Part of a membrane complex involved in electron transport
IT970_RS06055	COG4657	Part of a membrane complex involved in electron transport
IT970_RS06060	COG2200	EAL domain
IT970_RS06060	COG2199	diguanylate cyclase activity
IT970_RS06060	COG2203	Gaf domain
IT970_RS06085	COG0534	Mate efflux family protein
IT970_RS06090	COG0556	nucleotide-excision repair
IT970_RS06095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IT970_RS06125	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT970_RS06135	COG0730	response to heat
IT970_RS06140	COG1199	ATP-dependent helicase activity
IT970_RS06145	COG0417	DNA replication proofreading
IT970_RS06165	COG4206	TonB-dependent receptor
IT970_RS06170	COG0784	Response regulator, receiver
IT970_RS06170	COG2205	protein histidine kinase activity
IT970_RS06180	COG1061	Type III restriction enzyme res subunit
IT970_RS06190	COG0729	surface antigen
IT970_RS06195	COG2911	Protein conserved in bacteria
IT970_RS06200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IT970_RS06205	COG1643	Atp-dependent helicase
IT970_RS06210	COG0745	RESPONSE REGULATOR receiver
IT970_RS06220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IT970_RS06225	COG1418	mRNA catabolic process
IT970_RS06235	COG3437	response regulator, receiver
IT970_RS06240	COG0784	Response regulator, receiver
IT970_RS06240	COG2205	protein histidine kinase activity
IT970_RS06240	COG2198	Histidine kinase
IT970_RS06260	COG3547	Transposase (IS116 IS110 IS902 family)
IT970_RS06285	COG3012	SEC-C Motif Domain Protein
IT970_RS06300	COG1136	(ABC) transporter
IT970_RS06310	COG1960	acyl-CoA dehydrogenase activity
IT970_RS06315	COG0121	glutamine amidotransferase
IT970_RS06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IT970_RS06330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IT970_RS06335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT970_RS06340	COG2226	methyltransferase
IT970_RS06360	COG1451	nucleotide metabolic process
IT970_RS06365	COG1801	Protein of unknown function DUF72
IT970_RS06370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IT970_RS06405	COG0513	Belongs to the DEAD box helicase family
IT970_RS06425	COG2971	BadF BadG BcrA BcrD
IT970_RS06430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT970_RS06440	COG0363	glucosamine-6-phosphate deaminase activity
IT970_RS06445	COG2816	NAD+ diphosphatase activity
IT970_RS06450	COG0626	cystathionine gamma-synthase activity
IT970_RS06460	COG1131	(ABC) transporter
IT970_RS06480	COG1960	acyl-CoA dehydrogenase activity
IT970_RS06490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IT970_RS06505	COG2197	response regulator
IT970_RS06510	COG0322	excinuclease ABC activity
IT970_RS06565	COG1115	amino acid carrier protein
IT970_RS06590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT970_RS06595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IT970_RS06600	COG0072	phenylalanine-tRNA ligase activity
IT970_RS06605	COG0776	regulation of translation
IT970_RS06620	COG2866	Carboxypeptidase
IT970_RS06625	COG1115	amino acid carrier protein
IT970_RS06635	COG3139	Protein of unknown function (DUF1315)
IT970_RS06650	COG3604	Transcriptional regulator
IT970_RS06675	COG0628	permease
IT970_RS06700	COG2350	Protein conserved in bacteria
IT970_RS06705	COG0733	neurotransmitter:sodium symporter activity
IT970_RS06715	COG2917	probably involved in intracellular septation
IT970_RS06720	COG0776	regulation of translation
IT970_RS06725	COG0693	protein deglycase activity
IT970_RS06740	COG0134	indole-3-glycerol-phosphate synthase activity
IT970_RS06740	COG0135	phosphoribosylanthranilate isomerase activity
IT970_RS06745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT970_RS06750	COG0512	Glutamine amidotransferase of anthranilate synthase
IT970_RS06755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT970_RS06760	COG0613	PHP domain protein
IT970_RS06765	COG0009	L-threonylcarbamoyladenylate synthase
IT970_RS06775	COG3038	cytochrome b561
IT970_RS06805	COG4771	TonB-dependent receptor
IT970_RS06830	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IT970_RS06840	COG0604	alcohol dehydrogenase
IT970_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS06840	COG3321	synthase
IT970_RS06850	COG1476	TRANSCRIPTIONal
IT970_RS06870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT970_RS06870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT970_RS06875	COG0489	protein tyrosine kinase activity
IT970_RS06890	COG0717	Belongs to the dCTP deaminase family
IT970_RS06895	COG4251	negative regulation of phosphorylation
IT970_RS06895	COG5001	Diguanylate cyclase
IT970_RS06895	COG2203	Gaf domain
IT970_RS06895	COG3706	GGDEF domain
IT970_RS06915	COG0436	Aminotransferase
IT970_RS06920	COG3134	Outer membrane lipoprotein
IT970_RS06945	COG1876	peptidase activity
IT970_RS06950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT970_RS06955	COG1393	Belongs to the ArsC family
IT970_RS06970	COG0857	belongs to the CobB CobQ family
IT970_RS06970	COG0280	phosphate acetyltransferase
IT970_RS06975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IT970_RS06980	COG3092	negative regulation of chromosome organization
IT970_RS06985	COG2226	methyltransferase
IT970_RS07005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IT970_RS07010	COG1187	pseudouridine synthase activity
IT970_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS07025	COG0616	signal peptide processing
IT970_RS07030	COG1301	dicarboxylic acid transport
IT970_RS07035	COG1470	cell adhesion involved in biofilm formation
IT970_RS07035	COG1388	LysM domain
IT970_RS07050	COG2862	Uncharacterized protein family, UPF0114
IT970_RS07055	COG0366	Alpha amylase catalytic
IT970_RS07075	COG0366	Alpha amylase catalytic
IT970_RS07095	COG1944	ATP diphosphatase activity
IT970_RS07100	COG1609	Transcriptional regulator
IT970_RS07105	COG0837	glucose binding
IT970_RS07125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT970_RS07155	COG0217	transcriptional regulatory protein
IT970_RS07160	COG5265	(ABC) transporter
IT970_RS07165	COG1064	alcohol dehydrogenase
IT970_RS07175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT970_RS07180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT970_RS07185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT970_RS07190	COG4067	protein conserved in archaea
IT970_RS07190	COG0189	ligase activity
IT970_RS07200	COG1285	pathogenesis
IT970_RS07220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT970_RS07225	COG1595	DNA-templated transcription, initiation
IT970_RS07230	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IT970_RS07240	COG0583	DNA-binding transcription factor activity
IT970_RS07245	COG4591	ABC-type transport system involved in lipoprotein release permease component
IT970_RS07250	COG1136	(ABC) transporter
IT970_RS07255	COG4591	ABC-type transport system involved in lipoprotein release permease component
IT970_RS07275	COG2850	peptidyl-arginine hydroxylation
IT970_RS07280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IT970_RS07285	COG2915	High frequency lysogenization protein hflD homolog
IT970_RS07290	COG0482	sulfurtransferase activity
IT970_RS07300	COG1187	pseudouridine synthase activity
IT970_RS07305	COG2920	part of a sulfur-relay system
IT970_RS07320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IT970_RS07325	COG0670	Belongs to the BI1 family
IT970_RS07345	COG1956	GAF domain-containing protein
IT970_RS07355	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IT970_RS07365	COG1757	Na H antiporter
IT970_RS07370	COG0308	aminopeptidase N
IT970_RS07400	COG2902	Dehydrogenase
IT970_RS07405	COG0167	dihydroorotate dehydrogenase activity
IT970_RS07415	COG0116	Belongs to the methyltransferase superfamily
IT970_RS07415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IT970_RS07425	COG0488	(ABC) transporter
IT970_RS07440	COG2333	competence protein COMEC
IT970_RS07440	COG0658	competence protein
IT970_RS07445	COG1132	(ABC) transporter
IT970_RS07450	COG1663	tetraacyldisaccharide 4'-kinase activity
IT970_RS07455	COG2835	tetraacyldisaccharide 4'-kinase activity
IT970_RS07460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IT970_RS07465	COG0564	pseudouridine synthase activity
IT970_RS07470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IT970_RS07475	COG2166	iron-sulfur cluster assembly
IT970_RS07495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IT970_RS07500	COG1053	succinate dehydrogenase
IT970_RS07510	COG0567	Dehydrogenase, E1 component
IT970_RS07515	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT970_RS07520	COG0045	succinate-CoA ligase (ADP-forming) activity
IT970_RS07530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IT970_RS07530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT970_RS07540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT970_RS07555	COG0633	Ferredoxin
IT970_RS07560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT970_RS07565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT970_RS07575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT970_RS07585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IT970_RS07590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IT970_RS07595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IT970_RS07600	COG0539	negative regulation of cytoplasmic translation
IT970_RS07605	COG0776	regulation of translation
IT970_RS07615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IT970_RS07620	COG0284	orotidine-5'-phosphate decarboxylase activity
IT970_RS07630	COG0583	DNA-binding transcription factor activity
IT970_RS07635	COG0583	DNA-binding transcription factor activity
IT970_RS07640	COG0656	L-ascorbic acid biosynthetic process
IT970_RS07645	COG2249	NAD(P)H dehydrogenase (quinone) activity
IT970_RS07660	COG1054	Belongs to the UPF0176 family
IT970_RS07665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT970_RS07680	COG2176	DNA-directed DNA polymerase activity
IT970_RS07685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT970_RS07690	COG0367	asparagine synthase
IT970_RS07695	COG1984	allophanate hydrolase subunit 2
IT970_RS07705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT970_RS07790	COG5001	Diguanylate cyclase
IT970_RS07790	COG3706	GGDEF domain
IT970_RS07790	COG2203	Gaf domain
IT970_RS07790	COG4251	negative regulation of phosphorylation
IT970_RS07810	COG0583	DNA-binding transcription factor activity
IT970_RS07815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT970_RS07820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IT970_RS07830	COG4770	biotin carboxylase activity
IT970_RS07840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT970_RS07845	COG1960	acyl-CoA dehydrogenase activity
IT970_RS07870	COG1024	Enoyl-CoA hydratase
IT970_RS07875	COG1024	Enoyl-CoA hydratase
IT970_RS07875	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT970_RS07885	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS07915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT970_RS07930	COG4628	conserved protein (DUF2132)
IT970_RS07935	COG0604	alcohol dehydrogenase
IT970_RS07940	COG1309	transcriptional regulator
IT970_RS07945	COG3130	regulation of translation
IT970_RS07950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT970_RS07960	COG4942	peptidase
IT970_RS07965	COG1607	acyl-coa hydrolase
IT970_RS07970	COG2056	Na+-H+ antiporter family
IT970_RS07985	COG0714	Associated with various cellular activities
IT970_RS07990	COG2201	protein-glutamate methylesterase activity
IT970_RS08010	COG0488	(ABC) transporter
IT970_RS08015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IT970_RS08060	COG0281	malic enzyme
IT970_RS08065	COG0405	Gamma-glutamyltransferase
IT970_RS08090	COG2855	membrane
IT970_RS08100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IT970_RS08105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IT970_RS08110	COG0488	(ABC) transporter
IT970_RS08125	COG2329	Antibiotic biosynthesis monooxygenase
IT970_RS08150	COG0501	Belongs to the peptidase M48B family
IT970_RS08155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IT970_RS08160	COG2226	methyltransferase
IT970_RS08170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IT970_RS08175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT970_RS08185	COG0017	Asparaginyl-tRNA synthetase
IT970_RS08190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IT970_RS08220	COG1720	tRNA m6t6A37 methyltransferase activity
IT970_RS08225	COG0442	prolyl-tRNA aminoacylation
IT970_RS08240	COG1668	transmembrane transport
IT970_RS08245	COG4555	ABC transporter
IT970_RS08265	COG3152	Membrane
IT970_RS08275	COG0022	dehydrogenase e1 component
IT970_RS08280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IT970_RS08285	COG2988	succinylglutamate desuccinylase activity
IT970_RS08290	COG0033	Phosphoglucomutase
IT970_RS08295	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IT970_RS08300	COG0596	Alpha beta hydrolase
IT970_RS08320	COG0735	belongs to the Fur family
IT970_RS08325	COG0545	Peptidyl-prolyl cis-trans isomerase
IT970_RS08345	COG0778	Nitroreductase
IT970_RS08355	COG1902	pentaerythritol trinitrate reductase activity
IT970_RS08355	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT970_RS08360	COG0616	signal peptide processing
IT970_RS08365	COG0252	asparaginase activity
IT970_RS08370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IT970_RS08385	COG3275	phosphorelay sensor kinase activity
IT970_RS08390	COG0659	secondary active sulfate transmembrane transporter activity
IT970_RS08395	COG1522	sequence-specific DNA binding
IT970_RS08400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT970_RS08410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IT970_RS08415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IT970_RS08420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IT970_RS08440	COG0318	PFAM AMP-dependent synthetase and ligase
IT970_RS08445	COG5507	3-demethylubiquinone-9 3-methyltransferase
IT970_RS08450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IT970_RS08475	COG1132	(ABC) transporter
IT970_RS08485	COG1914	H( )-stimulated, divalent metal cation uptake system
IT970_RS08490	COG3119	arylsulfatase activity
IT970_RS08495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IT970_RS08500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT970_RS08505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IT970_RS08510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IT970_RS08515	COG1674	ftsk spoiiie
IT970_RS08515	COG0531	amino acid
IT970_RS08525	COG0686	Belongs to the AlaDH PNT family
IT970_RS08530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IT970_RS08535	COG0492	ferredoxin-NADP+ reductase activity
IT970_RS08540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IT970_RS08550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IT970_RS08555	COG0542	response to heat
IT970_RS08560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IT970_RS08565	COG1278	Cold shock
IT970_RS08580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT970_RS08600	COG3001	Fructosamine kinase
IT970_RS08610	COG0307	riboflavin synthase, alpha
IT970_RS08655	COG2211	Major facilitator Superfamily
IT970_RS08665	COG0789	Transcriptional regulator
IT970_RS08680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT970_RS08685	COG1280	lysine exporter protein (LysE YggA)
IT970_RS08690	COG3279	Response regulator of the LytR AlgR family
IT970_RS08695	COG2972	Histidine kinase
IT970_RS08700	COG1472	Belongs to the glycosyl hydrolase 3 family
IT970_RS08710	COG4771	TonB-dependent receptor
IT970_RS08740	COG2828	Protein conserved in bacteria
IT970_RS08745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IT970_RS08750	COG0372	Belongs to the citrate synthase family
IT970_RS08755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IT970_RS08765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IT970_RS08765	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IT970_RS08770	COG0726	polysaccharide deacetylase
IT970_RS08780	COG0084	hydrolase, TatD family'
IT970_RS08790	COG0470	DNA polymerase III
IT970_RS08795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IT970_RS08800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT970_RS08805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT970_RS08810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT970_RS08815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT970_RS08825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IT970_RS08830	COG0416	fatty acid biosynthetic process
IT970_RS08835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IT970_RS08840	COG1399	metal-binding, possibly nucleic acid-binding protein
IT970_RS08845	COG0424	maF-like protein
IT970_RS08850	COG0546	phosphoglycolate phosphatase activity
IT970_RS08855	COG0564	pseudouridine synthase activity
IT970_RS08860	COG1530	ribonuclease E activity
IT970_RS08880	COG0662	Cupin 2, conserved barrel domain protein
IT970_RS08895	COG3082	Protein of unknown function (DUF1414)
IT970_RS08910	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IT970_RS08930	COG0848	biopolymer transport protein
IT970_RS08965	COG2957	Belongs to the agmatine deiminase family
IT970_RS08970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT970_RS08975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IT970_RS09000	COG3278	Belongs to the heme-copper respiratory oxidase family
IT970_RS09015	COG2010	Cytochrome c
IT970_RS09025	COG2217	Heavy metal translocating P-type atpase
IT970_RS09040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT970_RS09045	COG0589	response to stress
IT970_RS09050	COG0037	tRNA processing
IT970_RS09055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT970_RS09075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IT970_RS09085	COG1505	serine-type exopeptidase activity
IT970_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS09115	COG1473	amidohydrolase
IT970_RS09125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT970_RS09130	COG1074	ATP-dependent DNA helicase activity
IT970_RS09135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IT970_RS09140	COG1902	pentaerythritol trinitrate reductase activity
IT970_RS09155	COG3385	transposase activity
IT970_RS09180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IT970_RS09220	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IT970_RS09225	COG2885	chlorophyll binding
IT970_RS09230	COG0823	Involved in the tonB-independent uptake of proteins
IT970_RS09245	COG0811	peptide transport
IT970_RS09255	COG2255	four-way junction helicase activity
IT970_RS09260	COG0632	four-way junction helicase activity
IT970_RS09265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IT970_RS09270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IT970_RS09275	COG4181	ATPase activity
IT970_RS09280	COG2755	lipolytic protein G-D-S-L family
IT970_RS09300	COG3081	Nucleoid-associated protein
IT970_RS09315	COG1090	epimerase
IT970_RS09350	COG2925	Exonuclease
IT970_RS09360	COG2084	Dehydrogenase
IT970_RS09365	COG0386	Belongs to the glutathione peroxidase family
IT970_RS09370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT970_RS09375	COG0733	neurotransmitter:sodium symporter activity
IT970_RS09385	COG0527	aspartate kinase activity
IT970_RS09390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT970_RS09430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT970_RS09440	COG2989	Protein conserved in bacteria
IT970_RS09455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT970_RS09460	COG0583	DNA-binding transcription factor activity
IT970_RS09470	COG1619	proteins homologs of microcin C7 resistance protein MccF
IT970_RS09480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IT970_RS09485	COG0505	Belongs to the CarA family
IT970_RS09490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IT970_RS09515	COG2814	Major facilitator Superfamily
IT970_RS09520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IT970_RS09525	COG1420	regulation of RNA biosynthetic process
IT970_RS09530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IT970_RS09540	COG0497	DNA recombination
IT970_RS09555	COG0493	'glutamate synthase
IT970_RS09560	COG0069	glutamate synthase activity
IT970_RS09560	COG0070	glutamate synthase
IT970_RS09560	COG0067	glutamate synthase
IT970_RS09570	COG1136	(ABC) transporter
IT970_RS09580	COG1136	(ABC) transporter
IT970_RS09580	COG0577	efflux transmembrane transporter activity
IT970_RS09585	COG2204	response regulator
IT970_RS09595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IT970_RS09600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IT970_RS09605	COG2766	serine protein kinase
IT970_RS09615	COG2719	SpoVR family
IT970_RS09620	COG0589	response to stress
IT970_RS09630	COG2201	protein-glutamate methylesterase activity
IT970_RS09635	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IT970_RS09640	COG0563	adenylate kinase activity
IT970_RS09645	COG0326	Molecular chaperone. Has ATPase activity
IT970_RS09650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IT970_RS09655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IT970_RS09660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IT970_RS09665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT970_RS09670	COG3219	Protein conserved in bacteria
IT970_RS09675	COG3220	belongs to the UPF0276 family
IT970_RS09685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT970_RS09710	COG0848	biopolymer transport protein
IT970_RS09715	COG0811	peptide transport
IT970_RS09720	COG0811	peptide transport
IT970_RS09735	COG1278	Cold shock
IT970_RS09740	COG0418	dihydroorotase activity
IT970_RS09745	COG3300	MHYT domain
IT970_RS09745	COG5001	Diguanylate cyclase
IT970_RS09750	COG0583	DNA-binding transcription factor activity
IT970_RS09755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IT970_RS09760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IT970_RS09775	COG1309	transcriptional regulator
IT970_RS09780	COG0402	S-adenosylhomocysteine deaminase activity
IT970_RS09785	COG3228	Belongs to the MtfA family
IT970_RS09795	COG3706	GGDEF domain
IT970_RS09815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT970_RS09825	COG1760	l-serine dehydratase
IT970_RS09830	COG0583	DNA-binding transcription factor activity
IT970_RS09840	COG2252	PERMEase
IT970_RS09895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT970_RS09900	COG0328	RNA-DNA hybrid ribonuclease activity
IT970_RS09910	COG2226	methyltransferase
IT970_RS09915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT970_RS09920	COG1388	LysM domain
IT970_RS09920	COG0741	lytic transglycosylase activity
IT970_RS09930	COG1166	arginine decarboxylase activity
IT970_RS09945	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IT970_RS09960	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IT970_RS09965	COG2363	Small membrane protein
IT970_RS09975	COG0583	DNA-binding transcription factor activity
IT970_RS09980	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IT970_RS09995	COG3094	Invasion gene expression up-regulator, SirB
IT970_RS10000	COG3437	response regulator, receiver
IT970_RS10000	COG0784	Response regulator, receiver
IT970_RS10005	COG2890	protein-(glutamine-N5) methyltransferase activity
IT970_RS10010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IT970_RS10015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IT970_RS10020	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IT970_RS10025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IT970_RS10030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IT970_RS10035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IT970_RS10040	COG0193	aminoacyl-tRNA hydrolase activity
IT970_RS10045	COG0012	GTP binding
IT970_RS10100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT970_RS10105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT970_RS10110	COG1702	phosphate starvation-inducible protein PhoH
IT970_RS10115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IT970_RS10120	COG4535	Mg2 and Co2 transporter CorC
IT970_RS10125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT970_RS10130	COG0545	Peptidyl-prolyl cis-trans isomerase
IT970_RS10135	COG1067	ATP-dependent peptidase activity
IT970_RS10140	COG2888	peptidyl-tyrosine sulfation
IT970_RS10145	COG0495	leucyl-tRNA aminoacylation
IT970_RS10160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IT970_RS10165	COG0799	negative regulation of ribosome biogenesis
IT970_RS10170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IT970_RS10175	COG0768	penicillin binding
IT970_RS10180	COG0772	Belongs to the SEDS family
IT970_RS10185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IT970_RS10190	COG1686	Belongs to the peptidase S11 family
IT970_RS10195	COG2921	Belongs to the UPF0250 family
IT970_RS10200	COG0321	lipoyl(octanoyl) transferase activity
IT970_RS10205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IT970_RS10215	COG1309	transcriptional regulator
IT970_RS10240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT970_RS10245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT970_RS10255	COG0702	epimerase
IT970_RS10295	COG0814	amino acid
IT970_RS10340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT970_RS10345	COG0149	triose-phosphate isomerase activity
IT970_RS10350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT970_RS10355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IT970_RS10360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT970_RS10365	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IT970_RS10370	COG1534	Rna-binding protein
IT970_RS10385	COG3713	MltA-interacting MipA family protein
IT970_RS10395	COG0745	RESPONSE REGULATOR receiver
IT970_RS10405	COG0733	neurotransmitter:sodium symporter activity
IT970_RS10415	COG4326	sporulation control protein
IT970_RS10435	COG2205	protein histidine kinase activity
IT970_RS10440	COG0745	RESPONSE REGULATOR receiver
IT970_RS10455	COG3706	GGDEF domain
IT970_RS10460	COG0583	DNA-binding transcription factor activity
IT970_RS10465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IT970_RS10470	COG0840	transmembrane signaling receptor activity
IT970_RS10490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT970_RS10495	COG2914	Belongs to the UPF0125 (RnfH) family
IT970_RS10500	COG2867	negative regulation of translational initiation
IT970_RS10505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IT970_RS10510	COG4206	TonB-dependent receptor
IT970_RS10515	COG0450	alkyl hydroperoxide reductase
IT970_RS10525	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IT970_RS10530	COG1605	Chorismate mutase
IT970_RS10530	COG0287	Prephenate dehydrogenase
IT970_RS10535	COG0335	large ribosomal subunit rRNA binding
IT970_RS10540	COG0336	Belongs to the RNA methyltransferase TrmD family
IT970_RS10545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IT970_RS10550	COG0228	four-way junction DNA binding
IT970_RS10555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IT970_RS10560	COG4137	Cytochrome C assembly protein
IT970_RS10565	COG4536	flavin adenine dinucleotide binding
IT970_RS10570	COG0668	transmembrane transport
IT970_RS10580	COG2918	glutathione biosynthetic process
IT970_RS10585	COG0840	transmembrane signaling receptor activity
IT970_RS10590	COG0542	response to heat
IT970_RS10595	COG1496	oxidoreductase activity
IT970_RS10600	COG0564	pseudouridine synthase activity
IT970_RS10605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT970_RS10655	COG3275	phosphorelay sensor kinase activity
IT970_RS10660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IT970_RS10665	COG1047	Peptidyl-prolyl cis-trans
IT970_RS10670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IT970_RS10675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IT970_RS10680	COG0196	riboflavin kinase activity
IT970_RS10685	COG0728	peptidoglycan biosynthetic process
IT970_RS10690	COG0268	Binds directly to 16S ribosomal RNA
IT970_RS10695	COG2201	protein-glutamate methylesterase activity
IT970_RS10715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT970_RS10730	COG3047	cAMP biosynthetic process
IT970_RS10785	COG2194	sulfuric ester hydrolase activity
IT970_RS10805	COG1215	transferase activity, transferring glycosyl groups
IT970_RS10815	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IT970_RS10840	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT970_RS10845	COG0739	heme binding
IT970_RS10865	COG1404	Belongs to the peptidase S8 family
IT970_RS10870	COG1280	lysine exporter protein (LysE YggA)
IT970_RS10875	COG1803	Methylglyoxal synthase
IT970_RS10880	COG0443	Heat shock 70 kDa protein
IT970_RS10885	COG1793	dna ligase
IT970_RS10890	COG0546	phosphoglycolate phosphatase activity
IT970_RS10900	COG4771	TonB-dependent receptor
IT970_RS10905	COG0668	transmembrane transport
IT970_RS10915	COG3264	Mechanosensitive ion channel
IT970_RS10915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IT970_RS10925	COG0339	signal peptide processing
IT970_RS10930	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IT970_RS10950	COG0583	DNA-binding transcription factor activity
IT970_RS10955	COG0693	protein deglycase activity
IT970_RS10975	COG0625	glutathione transferase activity
IT970_RS10990	COG1073	alpha beta
IT970_RS11000	COG0415	Belongs to the DNA photolyase family
IT970_RS11015	COG1764	response to oxidative stress
IT970_RS11040	COG0589	response to stress
IT970_RS11045	COG2814	Major facilitator Superfamily
IT970_RS11050	COG4249	Peptidase C14 caspase catalytic subunit p20
IT970_RS11050	COG2319	Wd-40 repeat
IT970_RS11060	COG5001	Diguanylate cyclase
IT970_RS11060	COG4251	negative regulation of phosphorylation
IT970_RS11060	COG3706	GGDEF domain
IT970_RS11060	COG2203	Gaf domain
IT970_RS11080	COG2239	Acts as a magnesium transporter
IT970_RS11105	COG1620	l-lactate permease
IT970_RS11120	COG3706	GGDEF domain
IT970_RS11130	COG0823	Involved in the tonB-independent uptake of proteins
IT970_RS11130	COG4946	Tricorn protease homolog
IT970_RS11130	COG1506	peptidase
IT970_RS11140	COG0738	Major facilitator superfamily
IT970_RS11170	COG0415	Belongs to the DNA photolyase family
IT970_RS11180	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IT970_RS11195	COG4771	TonB-dependent receptor
IT970_RS11200	COG2267	carboxylic ester hydrolase activity
IT970_RS11230	COG1940	carbohydrate kinase activity
IT970_RS11230	COG1846	Transcriptional regulator
IT970_RS11240	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT970_RS11250	COG1472	Belongs to the glycosyl hydrolase 3 family
IT970_RS11270	COG1404	Belongs to the peptidase S8 family
IT970_RS11290	COG3706	GGDEF domain
IT970_RS11295	COG3038	cytochrome b561
IT970_RS11305	COG2239	Acts as a magnesium transporter
IT970_RS11310	COG0783	Belongs to the Dps family
IT970_RS11315	COG0598	Magnesium transport protein CorA
IT970_RS11340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT970_RS11360	COG5001	Diguanylate cyclase
IT970_RS11360	COG3706	GGDEF domain
IT970_RS11360	COG2203	Gaf domain
IT970_RS11360	COG4251	negative regulation of phosphorylation
IT970_RS11365	COG2207	Transcriptional regulator
IT970_RS11375	COG3940	Belongs to the glycosyl hydrolase 43 family
IT970_RS11415	COG1283	sodium-dependent phosphate transmembrane transporter activity
IT970_RS11420	COG0798	PFAM Bile acid sodium symporter
IT970_RS11440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT970_RS11440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT970_RS11445	COG0509	glycine decarboxylation via glycine cleavage system
IT970_RS11450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT970_RS11460	COG0583	DNA-binding transcription factor activity
IT970_RS11465	COG4774	siderophore transport
IT970_RS11470	COG0148	phosphopyruvate hydratase activity
IT970_RS11475	COG0504	CTP synthase activity
IT970_RS11480	COG3956	TIGRFAM MazG family protein
IT970_RS11485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT970_RS11490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IT970_RS11495	COG3437	response regulator, receiver
IT970_RS11495	COG3850	Histidine kinase
IT970_RS11495	COG4999	Histidine kinase
IT970_RS11495	COG2205	protein histidine kinase activity
IT970_RS11510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IT970_RS11515	COG1381	Involved in DNA repair and RecF pathway recombination
IT970_RS11525	COG0571	ribonuclease III activity
IT970_RS11530	COG0681	Belongs to the peptidase S26 family
IT970_RS11535	COG0481	GTPase activity
IT970_RS11545	COG3026	antisigma factor binding
IT970_RS11555	COG1595	DNA-templated transcription, initiation
IT970_RS11560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IT970_RS11570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IT970_RS11580	COG1047	Peptidyl-prolyl cis-trans
IT970_RS11605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT970_RS11610	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT970_RS11610	COG1024	Enoyl-CoA hydratase
IT970_RS11620	COG1346	cytolysis
IT970_RS11625	COG0668	transmembrane transport
IT970_RS11640	COG3507	Belongs to the glycosyl hydrolase 43 family
IT970_RS11705	COG1643	Atp-dependent helicase
IT970_RS11710	COG3237	CsbD-like
IT970_RS11715	COG2199	diguanylate cyclase activity
IT970_RS11715	COG2203	Gaf domain
IT970_RS11720	COG1410	methionine synthase
IT970_RS11720	COG0646	methionine synthase
IT970_RS11725	COG1410	methionine synthase
IT970_RS11725	COG0646	methionine synthase
IT970_RS11730	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IT970_RS11735	COG0488	(ABC) transporter
IT970_RS11745	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT970_RS11750	COG0109	protoheme IX farnesyltransferase activity
IT970_RS11770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT970_RS11790	COG1477	protein flavinylation
IT970_RS11795	COG2871	sodium ion transport
IT970_RS11800	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT970_RS11805	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT970_RS11810	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT970_RS11815	COG1805	sodium ion transport
IT970_RS11820	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT970_RS11825	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT970_RS11830	COG0271	Belongs to the BolA IbaG family
IT970_RS11840	COG2813	Specifically methylates the guanine in position
IT970_RS11855	COG2211	Major facilitator Superfamily
IT970_RS11870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT970_RS11875	COG0316	Belongs to the HesB IscA family
IT970_RS11895	COG1981	membrane
IT970_RS11900	COG0540	Belongs to the ATCase OTCase family
IT970_RS11905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IT970_RS11915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT970_RS11925	COG0004	ammonium transporteR
IT970_RS11950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT970_RS11955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IT970_RS11960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT970_RS11980	COG0668	transmembrane transport
IT970_RS11985	COG3022	response to hydroperoxide
IT970_RS12000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IT970_RS12005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT970_RS12010	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IT970_RS12015	COG1492	cobalamin metabolic process
IT970_RS12025	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IT970_RS12030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT970_RS12035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT970_RS12040	COG1120	ATPase activity
IT970_RS12075	COG3118	belongs to the thioredoxin family
IT970_RS12080	COG1473	amidohydrolase
IT970_RS12085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT970_RS12100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT970_RS12105	COG1722	exodeoxyribonuclease VII activity
IT970_RS12110	COG0142	geranyltranstransferase activity
IT970_RS12115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IT970_RS12130	COG3706	GGDEF domain
IT970_RS12135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT970_RS12145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT970_RS12150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IT970_RS12165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT970_RS12165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT970_RS12170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT970_RS12175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT970_RS12185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IT970_RS12190	COG0083	homoserine kinase activity
IT970_RS12200	COG4565	transcriptional regulatory protein
IT970_RS12205	COG4191	Histidine kinase
IT970_RS12210	COG2974	May be involved in recombination
IT970_RS12240	COG0840	transmembrane signaling receptor activity
IT970_RS12245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT970_RS12250	COG1966	Carbon starvation protein
IT970_RS12255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT970_RS12270	COG0667	Aldo Keto reductase
IT970_RS12280	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT970_RS12325	COG2211	Major facilitator Superfamily
IT970_RS12330	COG1609	Transcriptional regulator
IT970_RS12335	COG0784	Response regulator, receiver
IT970_RS12335	COG2205	protein histidine kinase activity
IT970_RS12340	COG0784	Response regulator, receiver
IT970_RS12345	COG4251	negative regulation of phosphorylation
IT970_RS12355	COG2204	response regulator
IT970_RS12360	COG0494	nUDIX hydrolase
IT970_RS12380	COG1012	belongs to the aldehyde dehydrogenase family
IT970_RS12405	COG4206	TonB-dependent receptor
IT970_RS12410	COG2807	transmembrane transport
IT970_RS12425	COG3300	MHYT domain
IT970_RS12425	COG5001	Diguanylate cyclase
IT970_RS12435	COG1960	acyl-CoA dehydrogenase activity
IT970_RS12445	COG0795	lipopolysaccharide-transporting ATPase activity
IT970_RS12450	COG0795	lipopolysaccharide-transporting ATPase activity
IT970_RS12455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT970_RS12460	COG2927	DNA polymerase III (CHI subunit)
IT970_RS12465	COG0525	valine-tRNA ligase activity
IT970_RS12480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IT970_RS12485	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IT970_RS12490	COG0204	Acyl-transferase
IT970_RS12505	COG0187	DNA topoisomerase II activity
IT970_RS12510	COG3150	esterase
IT970_RS12520	COG3151	Protein conserved in bacteria
IT970_RS12525	COG0494	nUDIX hydrolase
IT970_RS12530	COG1538	Outer membrane efflux protein
IT970_RS12535	COG1560	Kdo2-lipid A biosynthetic process
IT970_RS12545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IT970_RS12560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IT970_RS12565	COG0189	ligase activity
IT970_RS12570	COG1678	Uncharacterized ACR, COG1678
IT970_RS12575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IT970_RS12600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IT970_RS12605	COG0762	integral membrane protein
IT970_RS12615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IT970_RS12620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT970_RS12645	COG1042	CoA-binding domain protein
IT970_RS12645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT970_RS12645	COG0045	succinate-CoA ligase (ADP-forming) activity
IT970_RS12650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT970_RS12675	COG3313	Fe-S protein
IT970_RS12685	COG0701	Predicted permease
IT970_RS12690	COG0789	Transcriptional regulator
IT970_RS12695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT970_RS12705	COG2203	Gaf domain
IT970_RS12705	COG5001	Diguanylate cyclase
IT970_RS12705	COG3706	GGDEF domain
IT970_RS12705	COG4251	negative regulation of phosphorylation
IT970_RS12710	COG2205	protein histidine kinase activity
IT970_RS12710	COG0784	Response regulator, receiver
IT970_RS12770	COG0084	hydrolase, TatD family'
IT970_RS12795	COG0789	Transcriptional regulator
IT970_RS12880	COG2217	Heavy metal translocating P-type atpase
IT970_RS12885	COG0789	Transcriptional regulator
IT970_RS12900	COG2132	Multicopper oxidase
IT970_RS12920	COG2871	sodium ion transport
IT970_RS12930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT970_RS12975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IT970_RS12985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IT970_RS12990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IT970_RS13000	COG0564	pseudouridine synthase activity
IT970_RS13010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT970_RS13015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT970_RS13020	COG3178	'Phosphotransferase
IT970_RS13025	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT970_RS13030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT970_RS13035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IT970_RS13040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT970_RS13045	COG2967	ApaG domain
IT970_RS13050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IT970_RS13070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IT970_RS13075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IT970_RS13080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT970_RS13085	COG0142	geranyltranstransferase activity
IT970_RS13090	COG0039	L-malate dehydrogenase activity
IT970_RS13095	COG1438	arginine binding
IT970_RS13115	COG1840	ABC-type Fe3 transport system, periplasmic component
IT970_RS13120	COG3148	PFAM DTW domain containing protein
IT970_RS13125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT970_RS13130	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT970_RS13135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IT970_RS13140	COG2186	Transcriptional regulator
IT970_RS13145	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IT970_RS13150	COG3023	N-Acetylmuramoyl-L-alanine amidase
IT970_RS13185	COG0237	dephospho-CoA kinase activity
IT970_RS13190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IT970_RS13195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IT970_RS13205	COG0745	RESPONSE REGULATOR receiver
IT970_RS13210	COG2205	protein histidine kinase activity
IT970_RS13215	COG2267	carboxylic ester hydrolase activity
IT970_RS13225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IT970_RS13230	COG5001	Diguanylate cyclase
IT970_RS13230	COG3300	MHYT domain
IT970_RS13235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IT970_RS13240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IT970_RS13245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT970_RS13250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT970_RS13255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IT970_RS13260	COG4942	peptidase
IT970_RS13265	COG0793	Belongs to the peptidase S41A family
IT970_RS13275	COG3335	DDE superfamily endonuclease
IT970_RS13300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT970_RS13310	COG1561	YicC-like family, N-terminal region
IT970_RS13320	COG2197	response regulator
IT970_RS13330	COG0515	serine threonine protein kinase
IT970_RS13330	COG2815	serine threonine protein kinase
IT970_RS13335	COG0842	Transport permease protein
IT970_RS13335	COG1131	(ABC) transporter
IT970_RS13335	COG1716	ATPase activity
IT970_RS13345	COG1404	Belongs to the peptidase S8 family
IT970_RS13365	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT970_RS13370	COG2223	nitrite transmembrane transporter activity
IT970_RS13380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT970_RS13405	COG0826	peptidase U32
IT970_RS13410	COG0826	peptidase U32
IT970_RS13415	COG3154	lipid carrier protein
IT970_RS13425	COG2223	nitrite transmembrane transporter activity
IT970_RS13430	COG2197	response regulator
IT970_RS13435	COG0303	'Molybdopterin
IT970_RS13445	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IT970_RS13465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IT970_RS13470	COG0315	cyclic pyranopterin monophosphate synthase activity
IT970_RS13475	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT970_RS13480	COG0746	molybdenum cofactor guanylyltransferase activity
IT970_RS13485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IT970_RS13490	COG3850	Histidine kinase
IT970_RS13495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IT970_RS13500	COG1140	nitrate reductase beta subunit
IT970_RS13505	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IT970_RS13510	COG2181	nitrate reductase activity
IT970_RS13525	COG0194	GDP metabolic process
IT970_RS13530	COG1758	RNA polymerase activity
IT970_RS13535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT970_RS13550	COG2502	aspartate--ammonia ligase
IT970_RS13555	COG1522	sequence-specific DNA binding
IT970_RS13560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT970_RS13565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IT970_RS13575	COG0583	DNA-binding transcription factor activity
IT970_RS13590	COG2962	Rard protein
IT970_RS13595	COG0514	ATP-dependent DNA helicase (RecQ)
IT970_RS13620	COG0189	ligase activity
IT970_RS13625	COG0189	ligase activity
IT970_RS13625	COG4067	protein conserved in archaea
IT970_RS13670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT970_RS13675	COG0305	Participates in initiation and elongation during chromosome replication
IT970_RS13710	COG4968	Prepilin-type N-terminal cleavage methylation domain
IT970_RS13720	COG0359	binds to the 23S rRNA
IT970_RS13725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT970_RS13730	COG2965	DNA replication, synthesis of RNA primer
IT970_RS13735	COG0360	Binds together with S18 to 16S ribosomal RNA
IT970_RS13740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT970_RS13745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT970_RS13750	COG2003	Belongs to the UPF0758 family
IT970_RS13755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IT970_RS13765	COG1506	peptidase
IT970_RS13765	COG4946	Tricorn protease homolog
IT970_RS13765	COG0823	Involved in the tonB-independent uptake of proteins
IT970_RS13770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IT970_RS13780	COG2081	HI0933 family
IT970_RS13785	COG1404	Belongs to the peptidase S8 family
IT970_RS13790	COG0678	peroxiredoxin activity
IT970_RS13800	COG0742	ribosomal rna small subunit methyltransferase
IT970_RS13810	COG0339	signal peptide processing
IT970_RS13815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT970_RS13830	COG0312	modulator of DNA gyrase
IT970_RS13835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT970_RS13840	COG3164	Protein of unknown function
IT970_RS13845	COG1530	ribonuclease E activity
IT970_RS13850	COG0424	maF-like protein
IT970_RS13855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IT970_RS13860	COG1792	Involved in formation and maintenance of cell shape
IT970_RS13865	COG1077	Cell shape determining protein MreB Mrl
IT970_RS13875	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IT970_RS13880	COG5001	Diguanylate cyclase
IT970_RS13880	COG1716	ATPase activity
IT970_RS13885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT970_RS13900	COG1477	protein flavinylation
IT970_RS13905	COG0668	transmembrane transport
IT970_RS13910	COG0530	calcium, potassium:sodium antiporter activity
IT970_RS13915	COG1968	undecaprenyl-diphosphatase activity
IT970_RS13940	COG0629	single-stranded DNA binding
IT970_RS13945	COG2814	Major facilitator Superfamily
IT970_RS13950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IT970_RS13960	COG0180	Tryptophanyl-tRNA synthetase
IT970_RS13970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IT970_RS13985	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IT970_RS13995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IT970_RS14000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT970_RS14030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT970_RS14035	COG0460	homoserine dehydrogenase
IT970_RS14035	COG0527	aspartate kinase activity
IT970_RS14040	COG0626	cystathionine gamma-synthase activity
IT970_RS14045	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IT970_RS14050	COG0281	malic enzyme
IT970_RS14055	COG0254	rRNA binding
IT970_RS14060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IT970_RS14065	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IT970_RS14070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IT970_RS14075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IT970_RS14095	COG0671	phosphoesterase, PA-phosphatase related
IT970_RS14100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT970_RS14115	COG1228	amidohydrolase
IT970_RS14160	COG0312	modulator of DNA gyrase
IT970_RS14175	COG3590	peptidase
IT970_RS14180	COG0494	nUDIX hydrolase
IT970_RS14185	COG0653	protein targeting
IT970_RS14205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IT970_RS14220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IT970_RS14230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT970_RS14240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IT970_RS14290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IT970_RS14300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT970_RS14305	COG1596	polysaccharide export
IT970_RS14325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IT970_RS14350	COG2089	acid synthase
IT970_RS14360	COG1083	cytidylyl-transferase
IT970_RS14365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT970_RS14370	COG1086	Polysaccharide biosynthesis protein
IT970_RS14385	COG3137	Salt-induced outer membrane protein
IT970_RS14390	COG0668	transmembrane transport
IT970_RS14420	COG0443	Heat shock 70 kDa protein
IT970_RS14425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT970_RS14430	COG0316	Belongs to the HesB IscA family
IT970_RS14435	COG0822	iron-sulfur transferase activity
IT970_RS14440	COG1104	cysteine desulfurase activity
IT970_RS14445	COG1959	2 iron, 2 sulfur cluster binding
IT970_RS14450	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IT970_RS14465	COG2199	diguanylate cyclase activity
IT970_RS14475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT970_RS14480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT970_RS14485	COG1862	Preprotein translocase
IT970_RS14490	COG0343	queuine tRNA-ribosyltransferase activity
IT970_RS14495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IT970_RS14500	COG5002	protein histidine kinase activity
IT970_RS14500	COG5001	Diguanylate cyclase
IT970_RS14525	COG0583	DNA-binding transcription factor activity
IT970_RS14530	COG0306	phosphate transporter
IT970_RS14535	COG1392	Phosphate transport regulator
IT970_RS14545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT970_RS14550	COG0573	inorganic phosphate transmembrane transporter activity
IT970_RS14565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IT970_RS14570	COG0248	Ppx GppA phosphatase
IT970_RS14580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT970_RS14585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT970_RS14600	COG2995	paraquat-inducible protein a
IT970_RS14605	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IT970_RS14615	COG2824	Alkylphosphonate utilization operon protein PhnA
IT970_RS14625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IT970_RS14640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT970_RS14645	COG0741	lytic transglycosylase activity
IT970_RS14645	COG1388	LysM domain
IT970_RS14655	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS14665	COG3409	Peptidoglycan-binding domain 1 protein
IT970_RS14665	COG0793	Belongs to the peptidase S41A family
IT970_RS14675	COG4948	Mandelate Racemase Muconate Lactonizing
IT970_RS14685	COG2863	cytochrome
IT970_RS14690	COG3122	Protein conserved in bacteria
IT970_RS14695	COG2814	Major facilitator Superfamily
IT970_RS14700	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
IT970_RS14715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IT970_RS14730	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IT970_RS14735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IT970_RS14740	COG0330	HflC and HflK could
IT970_RS14745	COG0330	HflC and HflK could
IT970_RS14750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT970_RS14755	COG1923	regulation of RNA biosynthetic process
IT970_RS14760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IT970_RS14765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IT970_RS14770	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT970_RS14775	COG0802	atpase or kinase
IT970_RS14780	COG0439	Biotin carboxylase
IT970_RS14785	COG0511	ligase activity, forming carbon-carbon bonds
IT970_RS14790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT970_RS14795	COG4232	protein-disulfide reductase activity
IT970_RS14800	COG1324	tolerance protein
IT970_RS14805	COG3030	protein affecting phage T7 exclusion by the F plasmid
IT970_RS14810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IT970_RS14815	COG0459	protein refolding
IT970_RS14825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IT970_RS14825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IT970_RS14835	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IT970_RS14840	COG1765	OsmC-like protein
IT970_RS14850	COG1012	belongs to the aldehyde dehydrogenase family
IT970_RS14855	COG3138	arginine N-succinyltransferase
IT970_RS14860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT970_RS14895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT970_RS14910	COG2183	response to ionizing radiation
IT970_RS14915	COG1404	Belongs to the peptidase S8 family
IT970_RS14935	COG0596	Alpha beta hydrolase
IT970_RS14940	COG1040	competence protein
IT970_RS14950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IT970_RS14950	COG0316	Belongs to the HesB IscA family
IT970_RS14960	COG0534	Mate efflux family protein
IT970_RS14965	COG0726	polysaccharide deacetylase
IT970_RS14970	COG2201	protein-glutamate methylesterase activity
IT970_RS14975	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IT970_RS14980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IT970_RS14985	COG0840	transmembrane signaling receptor activity
IT970_RS14990	COG0835	chemotaxis
IT970_RS14995	COG2198	Histidine kinase
IT970_RS14995	COG0643	Histidine kinase
IT970_RS15000	COG0745	RESPONSE REGULATOR receiver
IT970_RS15010	COG1999	signal sequence binding
IT970_RS15015	COG0109	protoheme IX farnesyltransferase activity
IT970_RS15040	COG1845	cytochrome c oxidase, subunit III
IT970_RS15045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IT970_RS15050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT970_RS15055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT970_RS15065	COG2050	protein possibly involved in aromatic compounds catabolism
IT970_RS15100	COG1017	nitric oxide dioxygenase activity
IT970_RS15100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT970_RS15110	COG3604	Transcriptional regulator
IT970_RS15115	COG0583	DNA-binding transcription factor activity
IT970_RS15120	COG0431	NADPH-dependent FMN reductase
IT970_RS15140	COG0066	3-isopropylmalate dehydratase activity
IT970_RS15145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IT970_RS15150	COG0473	3-isopropylmalate dehydrogenase activity
IT970_RS15155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT970_RS15170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT970_RS15175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IT970_RS15180	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IT970_RS15185	COG1619	proteins homologs of microcin C7 resistance protein MccF
IT970_RS15190	COG0545	Peptidyl-prolyl cis-trans isomerase
IT970_RS15200	COG2900	Belongs to the SlyX family
IT970_RS15205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IT970_RS15210	COG0488	(ABC) transporter
IT970_RS15225	COG0429	hydrolase of the alpha beta-hydrolase fold
IT970_RS15230	COG3089	Belongs to the UPF0270 family
IT970_RS15245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT970_RS15270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IT970_RS15295	COG0537	adenosine 5'-monophosphoramidase activity
IT970_RS15315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT970_RS15320	COG0436	Aminotransferase
IT970_RS15325	COG0235	Class ii aldolase
IT970_RS15330	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IT970_RS15350	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IT970_RS15355	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IT970_RS15360	COG0069	glutamate synthase activity
IT970_RS15375	COG2226	methyltransferase
IT970_RS15390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT970_RS15395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT970_RS15400	COG0805	protein transport
IT970_RS15415	COG5001	Diguanylate cyclase
IT970_RS15415	COG4251	negative regulation of phosphorylation
IT970_RS15415	COG2203	Gaf domain
IT970_RS15415	COG3706	GGDEF domain
IT970_RS15435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT970_RS15440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT970_RS15445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IT970_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS15455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT970_RS15460	COG2610	gluconate transmembrane transporter activity
IT970_RS15465	COG4771	TonB-dependent receptor
IT970_RS15485	COG1136	(ABC) transporter
IT970_RS15485	COG0577	efflux transmembrane transporter activity
IT970_RS15495	COG2204	response regulator
IT970_RS15500	COG4191	Histidine kinase
IT970_RS15515	COG0784	Response regulator, receiver
IT970_RS15515	COG5002	protein histidine kinase activity
IT970_RS15515	COG2198	Histidine kinase
IT970_RS15525	COG4681	YaeQ
IT970_RS15540	COG0783	Belongs to the Dps family
IT970_RS15550	COG1770	oligopeptidase
IT970_RS15555	COG3397	chitin binding
IT970_RS15605	COG0676	glucose-6-phosphate 1-epimerase activity
IT970_RS15610	COG1846	Transcriptional regulator
IT970_RS15650	COG1741	Belongs to the pirin family
IT970_RS15655	COG0583	DNA-binding transcription factor activity
IT970_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
IT970_RS15675	COG2186	Transcriptional regulator
IT970_RS15685	COG3940	Belongs to the glycosyl hydrolase 43 family
IT970_RS15690	COG3507	Belongs to the glycosyl hydrolase 43 family
IT970_RS15705	COG2211	Major facilitator Superfamily
IT970_RS15745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT970_RS15765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT970_RS15785	COG0745	RESPONSE REGULATOR receiver
IT970_RS15790	COG2205	protein histidine kinase activity
IT970_RS15820	COG0513	Belongs to the DEAD box helicase family
IT970_RS15830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT970_RS15835	COG1349	DNA-binding transcription factor activity
IT970_RS15840	COG0110	maltose O-acetyltransferase activity
IT970_RS15885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT970_RS15890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IT970_RS15895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IT970_RS15900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IT970_RS15905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IT970_RS15910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT970_RS15915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IT970_RS15925	COG0356	it plays a direct role in the translocation of protons across the membrane
IT970_RS15935	COG1475	DNA binding
IT970_RS15940	COG1192	Involved in chromosome partitioning
IT970_RS15945	COG0357	Ribosomal RNA small subunit methyltransferase G
IT970_RS15950	COG0445	tRNA wobble uridine modification
IT970_RS15955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IT970_RS15960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IT970_RS15965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IT970_RS15980	COG0706	membrane insertase activity
IT970_RS15985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT970_RS15990	COG0594	ribonuclease P activity
IT970_RS15995	COG0230	Belongs to the bacterial ribosomal protein bL34 family