locus-tag	class	description
D172_RS00015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D172_RS00025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D172_RS00030	COG2346	COG2346, Truncated hemoglobins
D172_RS00035	COG0408	coproporphyrinogen oxidase activity
D172_RS00040	COG0009	L-threonylcarbamoyladenylate synthase
D172_RS00045	COG0551	DNA topoisomerase type I activity
D172_RS00050	COG2922	Belongs to the Smg family
D172_RS00055	COG0758	DNA mediated transformation
D172_RS00065	COG0242	peptide deformylase activity
D172_RS00070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D172_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D172_RS00075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D172_RS00080	COG0569	domain protein
D172_RS00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D172_RS00110	COG1739	Uncharacterized protein family UPF0029
D172_RS00115	COG0006	proline dipeptidase activity
D172_RS00120	COG0741	lytic transglycosylase activity
D172_RS00125	COG1250	3-hydroxyacyl-CoA dehydrogenase
D172_RS00125	COG1024	Enoyl-CoA hydratase
D172_RS00130	COG0183	Belongs to the thiolase family
D172_RS00135	COG0425	Belongs to the sulfur carrier protein TusA family
D172_RS00150	COG0751	glycine-tRNA ligase activity
D172_RS00155	COG0752	glycyl-tRNA synthetase alpha subunit
D172_RS00160	COG0187	DNA topoisomerase II activity
D172_RS00165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D172_RS00180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D172_RS00185	COG0594	ribonuclease P activity
D172_RS00190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D172_RS00195	COG0706	membrane insertase activity
D172_RS00200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D172_RS00205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D172_RS00210	COG0445	tRNA wobble uridine modification
D172_RS00215	COG0357	Ribosomal RNA small subunit methyltransferase G
D172_RS00220	COG1192	Involved in chromosome partitioning
D172_RS00225	COG1475	DNA binding
D172_RS00235	COG0356	it plays a direct role in the translocation of protons across the membrane
D172_RS00245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D172_RS00250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D172_RS00255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D172_RS00260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D172_RS00265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D172_RS00270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D172_RS00275	COG3710	Transcriptional regulator
D172_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D172_RS00295	COG2801	Transposase and inactivated derivatives
D172_RS00300	COG0577	efflux transmembrane transporter activity
D172_RS00300	COG1136	(ABC) transporter
D172_RS00350	COG1943	Transposase
D172_RS00355	COG4191	Histidine kinase
D172_RS00360	COG2204	response regulator
D172_RS00365	COG1566	PFAM secretion protein HlyD family protein
D172_RS00370	COG1136	(ABC) transporter
D172_RS00375	COG0577	efflux transmembrane transporter activity
D172_RS00405	COG0110	maltose O-acetyltransferase activity
D172_RS00410	COG1349	DNA-binding transcription factor activity
D172_RS00415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D172_RS00425	COG0513	Belongs to the DEAD box helicase family
D172_RS00435	COG4771	TonB-dependent receptor
D172_RS00450	COG1278	Cold shock
D172_RS00455	COG1278	Cold shock
D172_RS00490	COG5520	Belongs to the glycosyl hydrolase 30 family
D172_RS00490	COG4447	cellulose binding
D172_RS00490	COG3291	Pkd domain containing protein
D172_RS00520	COG2832	Protein of unknown function (DUF454)
D172_RS00535	COG0676	glucose-6-phosphate 1-epimerase activity
D172_RS00545	COG3428	Bacterial PH domain
D172_RS00595	COG1404	Belongs to the peptidase S8 family
D172_RS00600	COG1770	oligopeptidase
D172_RS00605	COG0784	Response regulator, receiver
D172_RS00605	COG5002	protein histidine kinase activity
D172_RS00610	COG0745	RESPONSE REGULATOR receiver
D172_RS00630	COG1238	metal cluster binding
D172_RS00635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D172_RS00640	COG0302	gtp cyclohydrolase
D172_RS00650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D172_RS00655	COG3132	Protein of unknown function, DUF480
D172_RS00660	COG2205	protein histidine kinase activity
D172_RS00660	COG5002	protein histidine kinase activity
D172_RS00660	COG0784	Response regulator, receiver
D172_RS00665	COG1944	ATP diphosphatase activity
D172_RS00675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D172_RS00680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D172_RS00680	COG3153	acetyltransferase
D172_RS00710	COG1187	pseudouridine synthase activity
D172_RS00735	COG1011	Hydrolase
D172_RS00740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D172_RS00750	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D172_RS00755	COG0019	diaminopimelate decarboxylase activity
D172_RS00765	COG1965	Belongs to the frataxin family
D172_RS00770	COG0400	carboxylic ester hydrolase activity
D172_RS00780	COG0181	hydroxymethylbilane synthase activity
D172_RS00785	COG2959	enzyme of heme biosynthesis
D172_RS00795	COG0784	Response regulator, receiver
D172_RS00795	COG2205	protein histidine kinase activity
D172_RS00800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D172_RS00805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D172_RS00805	COG0617	tRNA 3'-terminal CCA addition
D172_RS00805	COG0517	IMP dehydrogenase activity
D172_RS00815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D172_RS00830	COG2354	Protein conserved in bacteria
D172_RS00845	COG4774	siderophore transport
D172_RS00850	COG0513	Belongs to the DEAD box helicase family
D172_RS00870	COG3118	belongs to the thioredoxin family
D172_RS00875	COG0513	Belongs to the DEAD box helicase family
D172_RS00880	COG0248	Ppx GppA phosphatase
D172_RS00905	COG1444	tRNA N-acetyltransferase activity
D172_RS00910	COG0210	DNA helicase
D172_RS00920	COG3112	Uncharacterised protein family (UPF0231)
D172_RS00940	COG0717	Belongs to the dCTP deaminase family
D172_RS00945	COG1011	Hydrolase
D172_RS00950	COG0494	nUDIX hydrolase
D172_RS00955	COG1218	3'(2'),5'-bisphosphate nucleotidase
D172_RS00980	COG0606	chelatase, subunit chli
D172_RS00995	COG1253	flavin adenine dinucleotide binding
D172_RS01010	COG0784	Response regulator, receiver
D172_RS01010	COG0835	chemotaxis
D172_RS01025	COG1946	Acyl-CoA thioesterase
D172_RS01030	COG2937	Belongs to the GPAT DAPAT family
D172_RS01035	COG0051	transcription antitermination factor activity, RNA binding
D172_RS01040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D172_RS01045	COG0088	Forms part of the polypeptide exit tunnel
D172_RS01050	COG0089	rRNA binding
D172_RS01055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D172_RS01060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D172_RS01065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D172_RS01070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D172_RS01075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D172_RS01080	COG0255	Belongs to the universal ribosomal protein uL29 family
D172_RS01085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D172_RS01095	COG2356	endonuclease I
D172_RS01100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D172_RS01105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D172_RS01120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D172_RS01145	COG2204	response regulator
D172_RS01150	COG3852	Histidine kinase
D172_RS01160	COG0174	glutamine synthetase
D172_RS01170	COG1217	gtp-binding protein TYPA
D172_RS01195	COG1295	ribonuclease BN
D172_RS01200	COG1490	D-aminoacyl-tRNA deacylase activity
D172_RS01210	COG0456	acetyltransferase
D172_RS01225	COG0019	diaminopimelate decarboxylase activity
D172_RS01235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D172_RS01245	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D172_RS01250	COG2885	chlorophyll binding
D172_RS01265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D172_RS01270	COG1049	propionate catabolic process, 2-methylcitrate cycle
D172_RS01280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D172_RS01335	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D172_RS01345	COG2186	Transcriptional regulator
D172_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS01355	COG3734	2-keto-3-deoxy-galactonokinase
D172_RS01360	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D172_RS01375	COG0673	inositol 2-dehydrogenase activity
D172_RS01380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D172_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS01415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D172_RS01425	COG1012	belongs to the aldehyde dehydrogenase family
D172_RS01435	COG1765	OsmC-like protein
D172_RS01440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D172_RS01450	COG0814	amino acid
D172_RS01455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D172_RS01460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D172_RS01465	COG2313	pseudouridylate synthase activity
D172_RS01470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D172_RS01475	COG1846	Transcriptional regulator
D172_RS01480	COG1902	pentaerythritol trinitrate reductase activity
D172_RS01485	COG0697	spore germination
D172_RS01490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D172_RS01495	COG0135	phosphoribosylanthranilate isomerase activity
D172_RS01505	COG2267	carboxylic ester hydrolase activity
D172_RS01515	COG2801	Transposase and inactivated derivatives
D172_RS01535	COG1218	3'(2'),5'-bisphosphate nucleotidase
D172_RS01540	COG0529	Catalyzes the synthesis of activated sulfate
D172_RS01545	COG0471	metal ion transport
D172_RS01545	COG3273	potassium ion transport
D172_RS01550	COG2895	sulfate adenylyltransferase (ATP) activity
D172_RS01555	COG0175	sulfate reduction
D172_RS01560	COG1648	precorrin-2 dehydrogenase activity
D172_RS01560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D172_RS01565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D172_RS01590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D172_RS01595	COG0250	Participates in transcription elongation, termination and antitermination
D172_RS01600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D172_RS01605	COG0081	regulation of translation
D172_RS01610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D172_RS01615	COG0222	ribosome binding
D172_RS01620	COG0085	RNA polymerase activity
D172_RS01625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D172_RS01630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D172_RS01635	COG0049	tRNA binding
D172_RS01640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D172_RS01645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D172_RS01650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D172_RS01650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D172_RS01655	COG0346	lactoylglutathione lyase activity
D172_RS01670	COG0459	protein refolding
D172_RS01675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D172_RS01680	COG3030	protein affecting phage T7 exclusion by the F plasmid
D172_RS01685	COG1324	tolerance protein
D172_RS01690	COG4232	protein-disulfide reductase activity
D172_RS01695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D172_RS01700	COG0511	ligase activity, forming carbon-carbon bonds
D172_RS01705	COG0439	Biotin carboxylase
D172_RS01710	COG0802	atpase or kinase
D172_RS01715	COG0860	N-Acetylmuramoyl-L-alanine amidase
D172_RS01720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D172_RS01725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D172_RS01730	COG1923	regulation of RNA biosynthetic process
D172_RS01735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D172_RS01740	COG0330	HflC and HflK could
D172_RS01745	COG0330	HflC and HflK could
D172_RS01750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D172_RS01755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D172_RS01765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D172_RS01770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D172_RS01780	COG3850	Histidine kinase
D172_RS01780	COG4999	Histidine kinase
D172_RS01780	COG2205	protein histidine kinase activity
D172_RS01780	COG3437	response regulator, receiver
D172_RS01825	COG4948	Mandelate Racemase Muconate Lactonizing
D172_RS01855	COG3618	amidohydrolase
D172_RS01860	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS01870	COG0741	lytic transglycosylase activity
D172_RS01870	COG1388	LysM domain
D172_RS01885	COG3074	FtsZ-dependent cytokinesis
D172_RS01890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D172_RS01895	COG2824	Alkylphosphonate utilization operon protein PhnA
D172_RS01900	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D172_RS01925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D172_RS01955	COG0573	inorganic phosphate transmembrane transporter activity
D172_RS01960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D172_RS01970	COG1392	Phosphate transport regulator
D172_RS01975	COG0306	phosphate transporter
D172_RS01980	COG0583	DNA-binding transcription factor activity
D172_RS01990	COG5002	protein histidine kinase activity
D172_RS01990	COG5001	Diguanylate cyclase
D172_RS01995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D172_RS02000	COG0343	queuine tRNA-ribosyltransferase activity
D172_RS02005	COG1862	Preprotein translocase
D172_RS02010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D172_RS02015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D172_RS02045	COG2823	Periplasmic or secreted lipoprotein
D172_RS02080	COG2200	EAL domain
D172_RS02080	COG2771	luxR family
D172_RS02100	COG1280	lysine exporter protein (LysE YggA)
D172_RS02115	COG0123	including yeast histone deacetylase and acetoin utilization protein
D172_RS02130	COG5001	Diguanylate cyclase
D172_RS02135	COG0151	Belongs to the GarS family
D172_RS02145	COG0138	bifunctional purine biosynthesis protein purh
D172_RS02150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D172_RS02155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D172_RS02160	COG2264	protein methyltransferase activity
D172_RS02165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D172_RS02180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D172_RS02185	COG0742	ribosomal rna small subunit methyltransferase
D172_RS02190	COG0552	protein localization to endoplasmic reticulum
D172_RS02195	COG2884	Cell division ATP-binding protein ftsE
D172_RS02200	COG2177	Part of the ABC transporter FtsEX involved in
D172_RS02215	COG0793	Belongs to the peptidase S41A family
D172_RS02220	COG4942	peptidase
D172_RS02225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D172_RS02230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D172_RS02235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D172_RS02240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D172_RS02245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D172_RS02250	COG0840	transmembrane signaling receptor activity
D172_RS02265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D172_RS02275	COG2267	carboxylic ester hydrolase activity
D172_RS02280	COG2205	protein histidine kinase activity
D172_RS02285	COG0745	RESPONSE REGULATOR receiver
D172_RS02295	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D172_RS02300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D172_RS02305	COG0237	dephospho-CoA kinase activity
D172_RS02310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D172_RS02340	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D172_RS02345	COG2186	Transcriptional regulator
D172_RS02350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D172_RS02355	COG0508	dehydrogenase complex catalyzes the overall conversion of
D172_RS02360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D172_RS02365	COG3148	PFAM DTW domain containing protein
D172_RS02375	COG1840	ABC-type Fe3 transport system, periplasmic component
D172_RS02385	COG3842	ATPase activity
D172_RS02395	COG1438	arginine binding
D172_RS02400	COG0039	L-malate dehydrogenase activity
D172_RS02405	COG0142	geranyltranstransferase activity
D172_RS02410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D172_RS02415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D172_RS02420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D172_RS02435	COG0823	Involved in the tonB-independent uptake of proteins
D172_RS02435	COG1506	peptidase
D172_RS02435	COG4946	Tricorn protease homolog
D172_RS02445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D172_RS02450	COG2003	Belongs to the UPF0758 family
D172_RS02460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D172_RS02465	COG1404	Belongs to the peptidase S8 family
D172_RS02470	COG2081	HI0933 family
D172_RS02475	COG2207	Transcriptional regulator
D172_RS02480	COG0697	spore germination
D172_RS02495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D172_RS02525	COG1227	inorganic diphosphatase activity
D172_RS02535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D172_RS02555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D172_RS02560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D172_RS02565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D172_RS02570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D172_RS02580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D172_RS02585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D172_RS02595	COG0564	pseudouridine synthase activity
D172_RS02600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D172_RS02605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D172_RS02610	COG3437	response regulator, receiver
D172_RS02610	COG2205	protein histidine kinase activity
D172_RS02610	COG4999	Histidine kinase
D172_RS02610	COG3850	Histidine kinase
D172_RS02625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D172_RS02635	COG3313	Fe-S protein
D172_RS02655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D172_RS02660	COG0045	succinate-CoA ligase (ADP-forming) activity
D172_RS02660	COG1042	CoA-binding domain protein
D172_RS02660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D172_RS02680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D172_RS02685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D172_RS02695	COG0762	integral membrane protein
D172_RS02700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D172_RS02705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D172_RS02720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D172_RS02725	COG1678	Uncharacterized ACR, COG1678
D172_RS02730	COG0189	ligase activity
D172_RS02735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D172_RS02750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D172_RS02760	COG1560	Kdo2-lipid A biosynthetic process
D172_RS02765	COG1538	Outer membrane efflux protein
D172_RS02770	COG0494	nUDIX hydrolase
D172_RS02775	COG3151	Protein conserved in bacteria
D172_RS02785	COG3150	esterase
D172_RS02805	COG0204	Acyl-transferase
D172_RS02810	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D172_RS02825	COG0189	ligase activity
D172_RS02825	COG4067	protein conserved in archaea
D172_RS02830	COG0189	ligase activity
D172_RS02855	COG0514	ATP-dependent DNA helicase (RecQ)
D172_RS02860	COG2050	protein possibly involved in aromatic compounds catabolism
D172_RS02865	COG2962	Rard protein
D172_RS02875	COG3085	chromosome segregation
D172_RS02880	COG0583	DNA-binding transcription factor activity
D172_RS02890	COG1120	ATPase activity
D172_RS02895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D172_RS02900	COG1492	cobalamin metabolic process
D172_RS02905	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D172_RS02910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D172_RS02915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D172_RS02930	COG3022	response to hydroperoxide
D172_RS02935	COG0668	transmembrane transport
D172_RS02950	COG0513	Belongs to the DEAD box helicase family
D172_RS02955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D172_RS02970	COG0716	FMN binding
D172_RS02980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D172_RS02985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D172_RS02990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D172_RS02995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D172_RS03030	COG3876	Protein conserved in bacteria
D172_RS03035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D172_RS03040	COG1757	Na H antiporter
D172_RS03080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D172_RS03100	COG1509	lysine 2,3-aminomutase activity
D172_RS03105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D172_RS03110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D172_RS03115	COG1629	transport
D172_RS03115	COG4774	siderophore transport
D172_RS03130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D172_RS03145	COG2022	thiamine diphosphate biosynthetic process
D172_RS03150	COG0352	thiamine-phosphate diphosphorylase activity
D172_RS03155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D172_RS03160	COG0688	phosphatidylethanolamine metabolic process
D172_RS03170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D172_RS03190	COG0432	Pfam Uncharacterised protein family UPF0047
D172_RS03200	COG0735	belongs to the Fur family
D172_RS03205	COG2095	MarC family integral membrane protein
D172_RS03250	COG2977	Belongs to the P-Pant transferase superfamily
D172_RS03285	COG0019	diaminopimelate decarboxylase activity
D172_RS03295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D172_RS03300	COG1136	(ABC) transporter
D172_RS03305	COG0577	efflux transmembrane transporter activity
D172_RS03310	COG2963	transposase activity
D172_RS03330	COG1842	Phage shock protein A
D172_RS03370	COG5001	Diguanylate cyclase
D172_RS03370	COG3300	MHYT domain
D172_RS03375	COG1032	radical SAM domain protein
D172_RS03380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D172_RS03385	COG2239	Acts as a magnesium transporter
D172_RS03390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D172_RS03395	COG1660	Displays ATPase and GTPase activities
D172_RS03400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D172_RS03410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D172_RS03415	COG1137	ATPase activity
D172_RS03430	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D172_RS03445	COG1127	ABC transporter
D172_RS03450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D172_RS03455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D172_RS03460	COG2854	intermembrane phospholipid transfer
D172_RS03465	COG3113	response to antibiotic
D172_RS03470	COG5007	Belongs to the BolA IbaG family
D172_RS03475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D172_RS03485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D172_RS03495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D172_RS03500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D172_RS03505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D172_RS03510	COG0723	plastoquinol--plastocyanin reductase activity
D172_RS03515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D172_RS03520	COG2857	Cytochrome c1
D172_RS03525	COG0625	glutathione transferase activity
D172_RS03530	COG2969	positive regulation of protein catabolic process
D172_RS03535	COG2823	Periplasmic or secreted lipoprotein
D172_RS03545	COG0792	nuclease activity
D172_RS03550	COG3107	peptidoglycan biosynthetic process
D172_RS03555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D172_RS03575	COG2801	Transposase and inactivated derivatives
D172_RS03590	COG3630	sodium ion export across plasma membrane
D172_RS03605	COG4989	oxidoreductase activity
D172_RS03615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D172_RS03625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D172_RS03635	COG1469	GTP cyclohydrolase I activity
D172_RS03640	COG5002	protein histidine kinase activity
D172_RS03640	COG0784	Response regulator, receiver
D172_RS03640	COG2198	Histidine kinase
D172_RS03645	COG0745	RESPONSE REGULATOR receiver
D172_RS03650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D172_RS03650	COG4191	Histidine kinase
D172_RS03655	COG2813	Specifically methylates the guanine in position
D172_RS03660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D172_RS03670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D172_RS03675	COG5002	protein histidine kinase activity
D172_RS03675	COG0784	Response regulator, receiver
D172_RS03675	COG2205	protein histidine kinase activity
D172_RS03715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D172_RS03730	COG0006	proline dipeptidase activity
D172_RS03735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D172_RS03740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D172_RS03745	COG1024	Enoyl-CoA hydratase
D172_RS03750	COG0557	exoribonuclease II activity
D172_RS03755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D172_RS03760	COG4774	siderophore transport
D172_RS03775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D172_RS03780	COG0509	glycine decarboxylation via glycine cleavage system
D172_RS03785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D172_RS03785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D172_RS03855	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D172_RS03870	COG0784	Response regulator, receiver
D172_RS03870	COG2205	protein histidine kinase activity
D172_RS03895	COG0625	glutathione transferase activity
D172_RS03905	COG0360	Binds together with S18 to 16S ribosomal RNA
D172_RS03910	COG2965	DNA replication, synthesis of RNA primer
D172_RS03915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D172_RS03920	COG0359	binds to the 23S rRNA
D172_RS03925	COG1595	DNA-templated transcription, initiation
D172_RS03940	COG0305	Participates in initiation and elongation during chromosome replication
D172_RS03945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D172_RS03995	COG0525	valine-tRNA ligase activity
D172_RS04000	COG2927	DNA polymerase III (CHI subunit)
D172_RS04005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D172_RS04010	COG0795	lipopolysaccharide-transporting ATPase activity
D172_RS04015	COG0795	lipopolysaccharide-transporting ATPase activity
D172_RS04055	COG2807	transmembrane transport
D172_RS04060	COG2207	Transcriptional regulator
D172_RS04065	COG4206	TonB-dependent receptor
D172_RS04105	COG1012	belongs to the aldehyde dehydrogenase family
D172_RS04110	COG2070	2-Nitropropane dioxygenase
D172_RS04120	COG2204	response regulator
D172_RS04130	COG4251	negative regulation of phosphorylation
D172_RS04135	COG0784	Response regulator, receiver
D172_RS04140	COG2205	protein histidine kinase activity
D172_RS04140	COG0784	Response regulator, receiver
D172_RS04145	COG0179	Fumarylacetoacetate (FAA) hydrolase
D172_RS04150	COG0667	Aldo Keto reductase
D172_RS04160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D172_RS04165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D172_RS04170	COG0840	transmembrane signaling receptor activity
D172_RS04205	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D172_RS04230	COG2205	protein histidine kinase activity
D172_RS04240	COG2204	response regulator
D172_RS04250	COG0741	lytic transglycosylase activity
D172_RS04265	COG0617	tRNA 3'-terminal CCA addition
D172_RS04270	COG2205	protein histidine kinase activity
D172_RS04275	COG0745	RESPONSE REGULATOR receiver
D172_RS04290	COG0697	spore germination
D172_RS04295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D172_RS04305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D172_RS04345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D172_RS04365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D172_RS04370	COG0745	RESPONSE REGULATOR receiver
D172_RS04390	COG0513	Belongs to the DEAD box helicase family
D172_RS04395	COG2203	Gaf domain
D172_RS04395	COG2199	diguanylate cyclase activity
D172_RS04405	COG0612	Peptidase, M16
D172_RS04410	COG1045	serine acetyltransferase
D172_RS04420	COG1570	exodeoxyribonuclease VII activity
D172_RS04425	COG0517	IMP dehydrogenase activity
D172_RS04425	COG0516	GMP reductase activity
D172_RS04430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D172_RS04430	COG0519	Catalyzes the synthesis of GMP from XMP
D172_RS04450	COG0784	Response regulator, receiver
D172_RS04450	COG2205	protein histidine kinase activity
D172_RS04455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D172_RS04460	COG0018	arginyl-trna synthetase
D172_RS04465	COG0259	pyridoxamine-phosphate oxidase activity
D172_RS04470	COG0084	hydrolase, TatD family'
D172_RS04480	COG0560	Phosphoserine phosphatase
D172_RS04500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D172_RS04505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D172_RS04510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D172_RS04520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D172_RS04525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D172_RS04545	COG3123	guanosine phosphorylase activity
D172_RS04560	COG0454	-acetyltransferase
D172_RS04580	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D172_RS04600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D172_RS04605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D172_RS04610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D172_RS04615	COG0585	pseudouridine synthase activity
D172_RS04620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D172_RS04625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D172_RS04630	COG1238	metal cluster binding
D172_RS04635	COG1388	LysM domain
D172_RS04635	COG4942	peptidase
D172_RS04645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D172_RS04670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D172_RS04680	COG0788	formyltetrahydrofolate deformylase activity
D172_RS04715	COG0438	transferase activity, transferring glycosyl groups
D172_RS04760	COG2239	Acts as a magnesium transporter
D172_RS04775	COG3025	triphosphatase activity
D172_RS04790	COG2198	Histidine kinase
D172_RS04790	COG2205	protein histidine kinase activity
D172_RS04790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D172_RS04790	COG0784	Response regulator, receiver
D172_RS04800	COG3706	GGDEF domain
D172_RS04810	COG0004	ammonium transporteR
D172_RS04815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D172_RS04820	COG0840	transmembrane signaling receptor activity
D172_RS04825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D172_RS04830	COG0540	Belongs to the ATCase OTCase family
D172_RS04835	COG1981	membrane
D172_RS04845	COG3227	Zinc metalloprotease (Elastase)
D172_RS04850	COG0316	Belongs to the HesB IscA family
D172_RS04865	COG2211	Major facilitator Superfamily
D172_RS04880	COG2813	Specifically methylates the guanine in position
D172_RS04890	COG0271	Belongs to the BolA IbaG family
D172_RS04895	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D172_RS04900	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D172_RS04905	COG1805	sodium ion transport
D172_RS04910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D172_RS04915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D172_RS04920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D172_RS04925	COG2871	sodium ion transport
D172_RS04930	COG1477	protein flavinylation
D172_RS04935	COG2991	Protein conserved in bacteria
D172_RS04945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D172_RS04965	COG0109	protoheme IX farnesyltransferase activity
D172_RS04985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D172_RS05015	COG0123	including yeast histone deacetylase and acetoin utilization protein
D172_RS05025	COG0488	(ABC) transporter
D172_RS05030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D172_RS05035	COG1410	methionine synthase
D172_RS05035	COG0646	methionine synthase
D172_RS05040	COG0646	methionine synthase
D172_RS05040	COG1410	methionine synthase
D172_RS05070	COG3237	CsbD-like
D172_RS05075	COG1643	Atp-dependent helicase
D172_RS05125	COG1064	alcohol dehydrogenase
D172_RS05130	COG2814	Major facilitator Superfamily
D172_RS05150	COG2801	Transposase and inactivated derivatives
D172_RS05170	COG0415	Belongs to the DNA photolyase family
D172_RS05175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D172_RS05190	COG2205	protein histidine kinase activity
D172_RS05195	COG0745	RESPONSE REGULATOR receiver
D172_RS05220	COG0784	Response regulator, receiver
D172_RS05220	COG5002	protein histidine kinase activity
D172_RS05220	COG2205	protein histidine kinase activity
D172_RS05230	COG0625	glutathione transferase activity
D172_RS05245	COG0583	DNA-binding transcription factor activity
D172_RS05265	COG0339	signal peptide processing
D172_RS05270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D172_RS05270	COG3264	Mechanosensitive ion channel
D172_RS05285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D172_RS05295	COG0443	Heat shock 70 kDa protein
D172_RS05300	COG1803	Methylglyoxal synthase
D172_RS05325	COG0739	heme binding
D172_RS05330	COG0179	Fumarylacetoacetate (FAA) hydrolase
D172_RS05355	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D172_RS05365	COG1215	transferase activity, transferring glycosyl groups
D172_RS05385	COG2194	sulfuric ester hydrolase activity
D172_RS05405	COG3047	cAMP biosynthetic process
D172_RS05420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D172_RS05435	COG2201	protein-glutamate methylesterase activity
D172_RS05440	COG0268	Binds directly to 16S ribosomal RNA
D172_RS05445	COG0728	peptidoglycan biosynthetic process
D172_RS05450	COG0196	riboflavin kinase activity
D172_RS05455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D172_RS05460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D172_RS05465	COG1047	Peptidyl-prolyl cis-trans
D172_RS05470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D172_RS05475	COG2972	Histidine kinase
D172_RS05475	COG0745	RESPONSE REGULATOR receiver
D172_RS05525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D172_RS05530	COG0564	pseudouridine synthase activity
D172_RS05535	COG1496	oxidoreductase activity
D172_RS05540	COG0542	response to heat
D172_RS05545	COG0840	transmembrane signaling receptor activity
D172_RS05550	COG2918	glutathione biosynthetic process
D172_RS05560	COG4536	flavin adenine dinucleotide binding
D172_RS05565	COG4137	Cytochrome C assembly protein
D172_RS05570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D172_RS05575	COG0228	four-way junction DNA binding
D172_RS05580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D172_RS05585	COG0336	Belongs to the RNA methyltransferase TrmD family
D172_RS05590	COG0335	large ribosomal subunit rRNA binding
D172_RS05595	COG0287	Prephenate dehydrogenase
D172_RS05595	COG1605	Chorismate mutase
D172_RS05600	COG0077	Prephenate dehydratase
D172_RS05600	COG1605	Chorismate mutase
D172_RS05610	COG0023	Translation Initiation Factor
D172_RS05620	COG0745	RESPONSE REGULATOR receiver
D172_RS05630	COG1448	Aminotransferase
D172_RS05635	COG0814	amino acid
D172_RS05645	COG2885	chlorophyll binding
D172_RS05700	COG0702	epimerase
D172_RS05705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D172_RS05705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D172_RS05710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D172_RS05720	COG2315	Protein conserved in bacteria
D172_RS05745	COG3555	Aspartyl Asparaginyl beta-hydroxylase
D172_RS05775	COG1404	Belongs to the peptidase S8 family
D172_RS05790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D172_RS05800	COG5001	Diguanylate cyclase
D172_RS05800	COG3300	MHYT domain
D172_RS05805	COG1025	Belongs to the peptidase M16 family
D172_RS05810	COG2062	phosphohistidine phosphatase, SixA
D172_RS05815	COG0251	oxidation-reduction process
D172_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS05830	COG2840	Smr protein MutS2
D172_RS05835	COG2890	protein-(glutamine-N5) methyltransferase activity
D172_RS05840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D172_RS05870	COG3101	peptidyl-lysine hydroxylation
D172_RS05885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D172_RS05920	COG0477	Major facilitator Superfamily
D172_RS05940	COG2801	Transposase and inactivated derivatives
D172_RS05980	COG0123	including yeast histone deacetylase and acetoin utilization protein
D172_RS05990	COG0730	response to heat
D172_RS05995	COG1199	ATP-dependent helicase activity
D172_RS06000	COG0417	DNA replication proofreading
D172_RS06005	COG4206	TonB-dependent receptor
D172_RS06025	COG1061	Type III restriction enzyme res subunit
D172_RS06035	COG0729	surface antigen
D172_RS06050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D172_RS06050	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D172_RS06060	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D172_RS06090	COG3098	single-species biofilm formation
D172_RS06095	COG0564	pseudouridine synthase activity
D172_RS06105	COG0741	lytic transglycosylase activity
D172_RS06105	COG1388	LysM domain
D172_RS06110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D172_RS06115	COG2226	methyltransferase
D172_RS06120	COG0328	RNA-DNA hybrid ribonuclease activity
D172_RS06125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D172_RS06190	COG1960	acyl-CoA dehydrogenase activity
D172_RS06195	COG0121	glutamine amidotransferase
D172_RS06205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D172_RS06210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D172_RS06215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D172_RS06220	COG2226	methyltransferase
D172_RS06240	COG1451	nucleotide metabolic process
D172_RS06245	COG1801	Protein of unknown function DUF72
D172_RS06250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D172_RS06285	COG0513	Belongs to the DEAD box helicase family
D172_RS06310	COG0626	cystathionine gamma-synthase activity
D172_RS06335	COG1960	acyl-CoA dehydrogenase activity
D172_RS06345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D172_RS06350	COG1823	symporter activity
D172_RS06355	COG2197	response regulator
D172_RS06360	COG0322	excinuclease ABC activity
D172_RS06410	COG1115	amino acid carrier protein
D172_RS06440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D172_RS06445	COG0072	phenylalanine-tRNA ligase activity
D172_RS06450	COG0776	regulation of translation
D172_RS06465	COG2866	Carboxypeptidase
D172_RS06470	COG1115	amino acid carrier protein
D172_RS06480	COG3139	Protein of unknown function (DUF1315)
D172_RS06520	COG0210	DNA helicase
D172_RS06540	COG0840	transmembrane signaling receptor activity
D172_RS06560	COG2801	Transposase and inactivated derivatives
D172_RS06595	COG2801	Transposase and inactivated derivatives
D172_RS06615	COG2755	lipolytic protein G-D-S-L family
D172_RS06620	COG4181	ATPase activity
D172_RS06625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D172_RS06630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D172_RS06635	COG0632	four-way junction helicase activity
D172_RS06640	COG2255	four-way junction helicase activity
D172_RS06645	COG0811	peptide transport
D172_RS06660	COG0823	Involved in the tonB-independent uptake of proteins
D172_RS06665	COG2885	chlorophyll binding
D172_RS06670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D172_RS06715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D172_RS06725	COG0784	Response regulator, receiver
D172_RS06725	COG5002	protein histidine kinase activity
D172_RS06750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D172_RS06770	COG1902	pentaerythritol trinitrate reductase activity
D172_RS06790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D172_RS06795	COG1074	ATP-dependent DNA helicase activity
D172_RS06800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D172_RS06820	COG0037	tRNA processing
D172_RS06825	COG0589	response to stress
D172_RS06830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D172_RS06845	COG2217	Heavy metal translocating P-type atpase
D172_RS06855	COG2010	Cytochrome c
D172_RS06870	COG3278	Belongs to the heme-copper respiratory oxidase family
D172_RS06900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D172_RS06905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D172_RS06910	COG2957	Belongs to the agmatine deiminase family
D172_RS06930	COG0583	DNA-binding transcription factor activity
D172_RS06950	COG4771	TonB-dependent receptor
D172_RS06955	COG0848	biopolymer transport protein
D172_RS06970	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D172_RS06980	COG3083	sulfuric ester hydrolase activity
D172_RS06985	COG3082	Protein of unknown function (DUF1414)
D172_RS06990	COG3081	Nucleoid-associated protein
D172_RS06995	COG1530	ribonuclease E activity
D172_RS07005	COG0546	phosphoglycolate phosphatase activity
D172_RS07010	COG0424	maF-like protein
D172_RS07015	COG1399	metal-binding, possibly nucleic acid-binding protein
D172_RS07020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D172_RS07025	COG0416	fatty acid biosynthetic process
D172_RS07030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D172_RS07040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D172_RS07045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D172_RS07050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D172_RS07055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D172_RS07060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D172_RS07065	COG0470	DNA polymerase III
D172_RS07075	COG0084	hydrolase, TatD family'
D172_RS07085	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D172_RS07085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D172_RS07090	COG1802	Transcriptional regulator
D172_RS07095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D172_RS07100	COG0372	Belongs to the citrate synthase family
D172_RS07105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D172_RS07110	COG2828	Protein conserved in bacteria
D172_RS07150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D172_RS07155	COG2223	nitrite transmembrane transporter activity
D172_RS07160	COG2815	serine threonine protein kinase
D172_RS07160	COG0515	serine threonine protein kinase
D172_RS07170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D172_RS07175	COG0243	molybdopterin cofactor binding
D172_RS07185	COG0746	molybdenum cofactor guanylyltransferase activity
D172_RS07190	COG0521	Mo-molybdopterin cofactor biosynthetic process
D172_RS07195	COG0315	cyclic pyranopterin monophosphate synthase activity
D172_RS07200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D172_RS07205	COG0314	molybdopterin synthase activity
D172_RS07210	COG2258	MOSC domain
D172_RS07220	COG2197	response regulator
D172_RS07225	COG5001	Diguanylate cyclase
D172_RS07225	COG3300	MHYT domain
D172_RS07240	COG1648	precorrin-2 dehydrogenase activity
D172_RS07240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D172_RS07245	COG2146	nitrite reductase [NAD(P)H] activity
D172_RS07250	COG2146	nitrite reductase [NAD(P)H] activity
D172_RS07250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D172_RS07270	COG0625	glutathione transferase activity
D172_RS07275	COG0583	DNA-binding transcription factor activity
D172_RS07280	COG0589	response to stress
D172_RS07285	COG0659	secondary active sulfate transmembrane transporter activity
D172_RS07305	COG0463	Glycosyl transferase, family 2
D172_RS07310	COG0438	transferase activity, transferring glycosyl groups
D172_RS07340	COG0297	glycogen (starch) synthase activity
D172_RS07345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D172_RS07375	COG2204	response regulator
D172_RS07400	COG4968	Prepilin-type N-terminal cleavage methylation domain
D172_RS07425	COG2211	Major facilitator Superfamily
D172_RS07440	COG4771	TonB-dependent receptor
D172_RS07485	COG3693	PFAM glycoside hydrolase, family 10
D172_RS07490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D172_RS07500	COG0583	DNA-binding transcription factor activity
D172_RS07530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D172_RS07535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D172_RS07540	COG2115	Belongs to the xylose isomerase family
D172_RS07545	COG1070	Carbohydrate kinase
D172_RS07555	COG3507	Belongs to the glycosyl hydrolase 43 family
D172_RS07560	COG1609	Transcriptional regulator
D172_RS07565	COG0477	Major facilitator Superfamily
D172_RS07585	COG4942	peptidase
D172_RS07605	COG0789	Transcriptional regulator
D172_RS07660	COG3119	arylsulfatase activity
D172_RS07665	COG3119	arylsulfatase activity
D172_RS07700	COG4771	TonB-dependent receptor
D172_RS07710	COG3119	arylsulfatase activity
D172_RS07715	COG4948	Mandelate Racemase Muconate Lactonizing
D172_RS07720	COG3386	PFAM SMP-30 Gluconolaconase
D172_RS07725	COG2814	Major facilitator Superfamily
D172_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS07750	COG3734	2-keto-3-deoxy-galactonokinase
D172_RS07755	COG0800	Aldolase
D172_RS07760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D172_RS07765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D172_RS07815	COG0307	riboflavin synthase, alpha
D172_RS07825	COG3001	Fructosamine kinase
D172_RS07845	COG1228	amidohydrolase
D172_RS07860	COG1278	Cold shock
D172_RS07865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D172_RS07870	COG0542	response to heat
D172_RS07875	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D172_RS07880	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D172_RS07885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D172_RS07890	COG0492	ferredoxin-NADP+ reductase activity
D172_RS07895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D172_RS07900	COG0686	Belongs to the AlaDH PNT family
D172_RS07910	COG1674	ftsk spoiiie
D172_RS07910	COG0531	amino acid
D172_RS07915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D172_RS07920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D172_RS07925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D172_RS07930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D172_RS07975	COG2133	pyrroloquinoline quinone binding
D172_RS07985	COG3977	Valine--pyruvate aminotransferase
D172_RS07995	COG0826	peptidase U32
D172_RS08000	COG2205	protein histidine kinase activity
D172_RS08005	COG0745	RESPONSE REGULATOR receiver
D172_RS08020	COG3034	peptidoglycan biosynthetic process
D172_RS08025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D172_RS08030	COG0842	Transport permease protein
D172_RS08030	COG1129	ABC transporter
D172_RS08035	COG0842	Transport permease protein
D172_RS08050	COG2273	Hydrolase Family 16
D172_RS08055	COG1132	(ABC) transporter
D172_RS08095	COG2850	peptidyl-arginine hydroxylation
D172_RS08100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D172_RS08105	COG2915	High frequency lysogenization protein hflD homolog
D172_RS08110	COG0482	sulfurtransferase activity
D172_RS08115	COG5001	Diguanylate cyclase
D172_RS08115	COG4251	negative regulation of phosphorylation
D172_RS08115	COG2203	Gaf domain
D172_RS08115	COG3706	GGDEF domain
D172_RS08125	COG1187	pseudouridine synthase activity
D172_RS08130	COG2920	part of a sulfur-relay system
D172_RS08140	COG2923	Belongs to the DsrF TusC family
D172_RS08150	COG0670	Belongs to the BI1 family
D172_RS08185	COG1956	GAF domain-containing protein
D172_RS08195	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D172_RS08205	COG1757	Na H antiporter
D172_RS08210	COG0308	aminopeptidase N
D172_RS08230	COG4447	cellulose binding
D172_RS08240	COG2902	Dehydrogenase
D172_RS08245	COG0167	dihydroorotate dehydrogenase activity
D172_RS08255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D172_RS08255	COG0116	Belongs to the methyltransferase superfamily
D172_RS08265	COG0488	(ABC) transporter
D172_RS08280	COG0658	competence protein
D172_RS08280	COG2333	competence protein COMEC
D172_RS08285	COG1132	(ABC) transporter
D172_RS08290	COG1663	tetraacyldisaccharide 4'-kinase activity
D172_RS08295	COG2835	tetraacyldisaccharide 4'-kinase activity
D172_RS08300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D172_RS08305	COG0564	pseudouridine synthase activity
D172_RS08310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D172_RS08315	COG2166	iron-sulfur cluster assembly
D172_RS08320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D172_RS08335	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D172_RS08340	COG1053	succinate dehydrogenase
D172_RS08350	COG0567	Dehydrogenase, E1 component
D172_RS08355	COG0508	dehydrogenase complex catalyzes the overall conversion of
D172_RS08360	COG0045	succinate-CoA ligase (ADP-forming) activity
D172_RS08375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D172_RS08380	COG0735	belongs to the Fur family
D172_RS08400	COG0596	Alpha beta hydrolase
D172_RS08405	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D172_RS08410	COG0033	Phosphoglucomutase
D172_RS08415	COG2988	succinylglutamate desuccinylase activity
D172_RS08425	COG0022	dehydrogenase e1 component
D172_RS08455	COG4555	ABC transporter
D172_RS08460	COG1668	transmembrane transport
D172_RS08475	COG0442	prolyl-tRNA aminoacylation
D172_RS08480	COG1720	tRNA m6t6A37 methyltransferase activity
D172_RS08510	COG0017	Asparaginyl-tRNA synthetase
D172_RS08525	COG3842	ATPase activity
D172_RS08530	COG1178	ABC-type Fe3 transport system permease component
D172_RS08545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D172_RS08550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D172_RS08560	COG2226	methyltransferase
D172_RS08565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D172_RS08575	COG0501	Belongs to the peptidase M48B family
D172_RS08595	COG2801	Transposase and inactivated derivatives
D172_RS08640	COG1131	(ABC) transporter
D172_RS08665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D172_RS08700	COG0488	(ABC) transporter
D172_RS08705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D172_RS08710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D172_RS08730	COG0405	Gamma-glutamyltransferase
D172_RS08735	COG0281	malic enzyme
D172_RS08765	COG2198	Histidine kinase
D172_RS08765	COG5002	protein histidine kinase activity
D172_RS08765	COG0784	Response regulator, receiver
D172_RS08805	COG2201	protein-glutamate methylesterase activity
D172_RS08810	COG0714	Associated with various cellular activities
D172_RS08825	COG2056	Na+-H+ antiporter family
D172_RS08830	COG1607	acyl-coa hydrolase
D172_RS08845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D172_RS08850	COG3130	regulation of translation
D172_RS08855	COG1309	transcriptional regulator
D172_RS08860	COG0604	alcohol dehydrogenase
D172_RS08865	COG4628	conserved protein (DUF2132)
D172_RS08965	COG3547	Transposase (IS116 IS110 IS902 family)
D172_RS08980	COG4974	Belongs to the 'phage' integrase family
D172_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS09000	COG1024	Enoyl-CoA hydratase
D172_RS09005	COG1024	Enoyl-CoA hydratase
D172_RS09020	COG0183	Belongs to the thiolase family
D172_RS09030	COG1960	acyl-CoA dehydrogenase activity
D172_RS09035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D172_RS09045	COG4770	biotin carboxylase activity
D172_RS09055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D172_RS09065	COG0583	DNA-binding transcription factor activity
D172_RS09070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D172_RS09070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D172_RS09075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D172_RS09080	COG1984	allophanate hydrolase subunit 2
D172_RS09095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D172_RS09100	COG0367	asparagine synthase
D172_RS09115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D172_RS09120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D172_RS09125	COG2176	DNA-directed DNA polymerase activity
D172_RS09130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D172_RS09130	COG0517	IMP dehydrogenase activity
D172_RS09135	COG1054	Belongs to the UPF0176 family
D172_RS09155	COG0284	orotidine-5'-phosphate decarboxylase activity
D172_RS09160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D172_RS09170	COG0776	regulation of translation
D172_RS09175	COG0539	negative regulation of cytoplasmic translation
D172_RS09180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D172_RS09185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D172_RS09190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D172_RS09200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D172_RS09210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D172_RS09220	COG1012	belongs to the aldehyde dehydrogenase family
D172_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS09230	COG1063	alcohol dehydrogenase
D172_RS09245	COG3119	arylsulfatase activity
D172_RS09270	COG2706	6-phosphogluconolactonase activity
D172_RS09280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D172_RS09290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D172_RS09315	COG1085	galactose-1-phosphate uridylyltransferase
D172_RS09325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D172_RS09330	COG2814	Major facilitator Superfamily
D172_RS09340	COG2186	Transcriptional regulator
D172_RS09350	COG3119	arylsulfatase activity
D172_RS09360	COG2801	Transposase and inactivated derivatives
D172_RS09370	COG3738	Protein conserved in bacteria
D172_RS09400	COG5285	phytanoyl-CoA dioxygenase
D172_RS09445	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D172_RS09465	COG2124	cytochrome p450
D172_RS09470	COG4948	Mandelate Racemase Muconate Lactonizing
D172_RS09475	COG3386	PFAM SMP-30 Gluconolaconase
D172_RS09490	COG0545	Peptidyl-prolyl cis-trans isomerase
D172_RS09510	COG0778	Nitroreductase
D172_RS09520	COG1902	pentaerythritol trinitrate reductase activity
D172_RS09520	COG0446	pyridine nucleotide-disulphide oxidoreductase
D172_RS09525	COG0616	signal peptide processing
D172_RS09530	COG0252	asparaginase activity
D172_RS09535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D172_RS09540	COG0469	pyruvate kinase activity
D172_RS09545	COG3279	Response regulator of the LytR AlgR family
D172_RS09550	COG2972	Histidine kinase
D172_RS09555	COG0659	secondary active sulfate transmembrane transporter activity
D172_RS09560	COG1522	sequence-specific DNA binding
D172_RS09570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D172_RS09575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D172_RS09580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D172_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
D172_RS09600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D172_RS09605	COG4807	Protein conserved in bacteria
D172_RS09610	COG4591	ABC-type transport system involved in lipoprotein release permease component
D172_RS09615	COG1136	(ABC) transporter
D172_RS09620	COG4591	ABC-type transport system involved in lipoprotein release permease component
D172_RS09625	COG0583	DNA-binding transcription factor activity
D172_RS09650	COG1285	pathogenesis
D172_RS09675	COG1285	pathogenesis
D172_RS09685	COG0189	ligase activity
D172_RS09690	COG2824	Alkylphosphonate utilization operon protein PhnA
D172_RS09700	COG2207	Transcriptional regulator
D172_RS09730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D172_RS09735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D172_RS09745	COG5265	(ABC) transporter
D172_RS09750	COG3590	peptidase
D172_RS09755	COG0217	transcriptional regulatory protein
D172_RS09775	COG0800	Aldolase
D172_RS09785	COG1609	Transcriptional regulator
D172_RS09790	COG0837	glucose binding
D172_RS09795	COG1609	Transcriptional regulator
D172_RS09805	COG3279	Response regulator of the LytR AlgR family
D172_RS09815	COG1472	Belongs to the glycosyl hydrolase 3 family
D172_RS09825	COG4771	TonB-dependent receptor
D172_RS09845	COG0366	Alpha amylase catalytic
D172_RS09860	COG0366	Alpha amylase catalytic
D172_RS09865	COG2862	Uncharacterized protein family, UPF0114
D172_RS09875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D172_RS09885	COG1301	dicarboxylic acid transport
D172_RS09890	COG0616	signal peptide processing
D172_RS09895	COG2267	carboxylic ester hydrolase activity
D172_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS09905	COG1187	pseudouridine synthase activity
D172_RS09910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D172_RS09935	COG2226	methyltransferase
D172_RS09940	COG3092	negative regulation of chromosome organization
D172_RS09945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D172_RS09950	COG0280	phosphate acetyltransferase
D172_RS09950	COG0857	belongs to the CobB CobQ family
D172_RS09965	COG1393	Belongs to the ArsC family
D172_RS09970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D172_RS09975	COG1876	peptidase activity
D172_RS09990	COG3220	belongs to the UPF0276 family
D172_RS10010	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D172_RS10015	COG3134	Outer membrane lipoprotein
D172_RS10020	COG0436	Aminotransferase
D172_RS10040	COG0717	Belongs to the dCTP deaminase family
D172_RS10045	COG0489	protein tyrosine kinase activity
D172_RS10050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D172_RS10050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D172_RS10055	COG0800	Aldolase
D172_RS10075	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D172_RS10125	COG3038	cytochrome b561
D172_RS10135	COG0009	L-threonylcarbamoyladenylate synthase
D172_RS10140	COG0613	PHP domain protein
D172_RS10145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D172_RS10150	COG0512	Glutamine amidotransferase of anthranilate synthase
D172_RS10155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D172_RS10160	COG0134	indole-3-glycerol-phosphate synthase activity
D172_RS10160	COG0135	phosphoribosylanthranilate isomerase activity
D172_RS10175	COG0693	protein deglycase activity
D172_RS10185	COG2917	probably involved in intracellular septation
D172_RS10195	COG0733	neurotransmitter:sodium symporter activity
D172_RS10200	COG2350	Protein conserved in bacteria
D172_RS10230	COG0628	permease
D172_RS10235	COG1090	epimerase
D172_RS10240	COG1472	Belongs to the glycosyl hydrolase 3 family
D172_RS10250	COG2723	6-phospho-beta-galactosidase activity
D172_RS10255	COG2211	Major facilitator Superfamily
D172_RS10260	COG1609	Transcriptional regulator
D172_RS10275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D172_RS10280	COG1505	serine-type exopeptidase activity
D172_RS10290	COG4771	TonB-dependent receptor
D172_RS10305	COG0543	2 iron, 2 sulfur cluster binding
D172_RS10305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D172_RS10310	COG2133	pyrroloquinoline quinone binding
D172_RS10330	COG0662	Cupin 2, conserved barrel domain protein
D172_RS10345	COG3647	Membrane
D172_RS10350	COG0300	oxidoreductase activity
D172_RS10390	COG1472	Belongs to the glycosyl hydrolase 3 family
D172_RS10400	COG2211	Major facilitator Superfamily
D172_RS10410	COG0583	DNA-binding transcription factor activity
D172_RS10475	COG0596	Alpha beta hydrolase
D172_RS10600	COG4695	Portal protein
D172_RS10625	COG2186	Transcriptional regulator
D172_RS10645	COG1598	PFAM Uncharacterised protein family UPF0150
D172_RS10685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D172_RS10715	COG0582	viral genome integration into host DNA
D172_RS10720	COG2925	Exonuclease
D172_RS10725	COG2084	Dehydrogenase
D172_RS10730	COG0386	Belongs to the glutathione peroxidase family
D172_RS10735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D172_RS10740	COG0733	neurotransmitter:sodium symporter activity
D172_RS10750	COG0527	aspartate kinase activity
D172_RS10780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D172_RS10780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D172_RS10855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D172_RS10870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D172_RS10875	COG0505	Belongs to the CarA family
D172_RS10880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D172_RS10895	COG2267	carboxylic ester hydrolase activity
D172_RS10905	COG2814	Major facilitator Superfamily
D172_RS10910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D172_RS10915	COG1420	regulation of RNA biosynthetic process
D172_RS10920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D172_RS10930	COG0497	DNA recombination
D172_RS10940	COG2199	diguanylate cyclase activity
D172_RS10940	COG2203	Gaf domain
D172_RS10945	COG0493	'glutamate synthase
D172_RS10950	COG0070	glutamate synthase
D172_RS10950	COG0069	glutamate synthase activity
D172_RS10950	COG0067	glutamate synthase
D172_RS10960	COG1136	(ABC) transporter
D172_RS10965	COG1136	(ABC) transporter
D172_RS10965	COG0577	efflux transmembrane transporter activity
D172_RS10970	COG1136	(ABC) transporter
D172_RS10970	COG0577	efflux transmembrane transporter activity
D172_RS10975	COG2204	response regulator
D172_RS10980	COG5000	phosphorelay sensor kinase activity
D172_RS10985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D172_RS10990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D172_RS10995	COG2766	serine protein kinase
D172_RS11000	COG2718	Belongs to the UPF0229 family
D172_RS11005	COG2719	SpoVR family
D172_RS11010	COG0589	response to stress
D172_RS11020	COG2201	protein-glutamate methylesterase activity
D172_RS11025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D172_RS11030	COG0563	adenylate kinase activity
D172_RS11035	COG0326	Molecular chaperone. Has ATPase activity
D172_RS11040	COG0564	pseudouridine synthase activity
D172_RS11050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D172_RS11055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D172_RS11065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D172_RS11070	COG3219	Protein conserved in bacteria
D172_RS11075	COG3220	belongs to the UPF0276 family
D172_RS11085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D172_RS11110	COG0848	biopolymer transport protein
D172_RS11115	COG0811	peptide transport
D172_RS11120	COG0811	peptide transport
D172_RS11130	COG1278	Cold shock
D172_RS11135	COG0418	dihydroorotase activity
D172_RS11140	COG5001	Diguanylate cyclase
D172_RS11140	COG4251	negative regulation of phosphorylation
D172_RS11140	COG3706	GGDEF domain
D172_RS11140	COG2203	Gaf domain
D172_RS11145	COG0583	DNA-binding transcription factor activity
D172_RS11150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D172_RS11155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D172_RS11175	COG1228	amidohydrolase
D172_RS11180	COG3228	Belongs to the MtfA family
D172_RS11190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D172_RS11200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D172_RS11210	COG1760	l-serine dehydratase
D172_RS11215	COG2252	PERMEase
D172_RS11265	COG1418	mRNA catabolic process
D172_RS11270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D172_RS11285	COG1643	Atp-dependent helicase
D172_RS11290	COG1446	asparaginase
D172_RS11305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D172_RS11310	COG0166	Belongs to the GPI family
D172_RS11315	COG1104	cysteine desulfurase activity
D172_RS11335	COG4783	chaperone-mediated protein folding
D172_RS11340	COG1393	Belongs to the ArsC family
D172_RS11360	COG2854	intermembrane phospholipid transfer
D172_RS11365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D172_RS11370	COG3314	Sporulation integral membrane protein YlbJ
D172_RS11380	COG2716	regulation of RNA biosynthetic process
D172_RS11385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D172_RS11415	COG2801	Transposase and inactivated derivatives
D172_RS11430	COG2226	methyltransferase
D172_RS11435	COG0602	queuosine metabolic process
D172_RS11440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D172_RS11465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D172_RS11470	COG0556	nucleotide-excision repair
D172_RS11475	COG0534	Mate efflux family protein
D172_RS11505	COG2200	EAL domain
D172_RS11505	COG2199	diguanylate cyclase activity
D172_RS11510	COG4657	Part of a membrane complex involved in electron transport
D172_RS11525	COG4658	electron transport chain
D172_RS11530	COG4659	FMN binding
D172_RS11535	COG4660	Part of a membrane complex involved in electron transport
D172_RS11540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D172_RS11565	COG2801	Transposase and inactivated derivatives
D172_RS11570	COG0497	DNA recombination
D172_RS11600	COG1982	Orn Lys Arg decarboxylase major
D172_RS11620	COG2801	Transposase and inactivated derivatives
D172_RS11640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D172_RS11650	COG0800	Aldolase
D172_RS11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D172_RS11660	COG2271	Major facilitator Superfamily
D172_RS11665	COG1917	Cupin 2, conserved barrel domain protein
D172_RS11685	COG0346	lactoylglutathione lyase activity
D172_RS11690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D172_RS11695	COG0612	Peptidase, M16
D172_RS11780	COG2801	Transposase and inactivated derivatives
D172_RS11790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D172_RS11805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D172_RS11810	COG3115	cell septum assembly
D172_RS11815	COG1196	nuclear chromosome segregation
D172_RS11820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D172_RS11830	COG1566	PFAM secretion protein HlyD family protein
D172_RS11840	COG4269	membrane
D172_RS11860	COG1166	arginine decarboxylase activity
D172_RS11865	COG1742	UPF0060 membrane protein
D172_RS11885	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D172_RS11890	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D172_RS11895	COG2363	Small membrane protein
D172_RS11905	COG0583	DNA-binding transcription factor activity
D172_RS11910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D172_RS11915	COG5505	Protein of unknown function (DUF819)
D172_RS11930	COG3437	response regulator, receiver
D172_RS11930	COG0784	Response regulator, receiver
D172_RS11935	COG2890	protein-(glutamine-N5) methyltransferase activity
D172_RS11940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D172_RS11945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D172_RS11950	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D172_RS11955	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D172_RS11965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D172_RS11970	COG0193	aminoacyl-tRNA hydrolase activity
D172_RS11975	COG0012	GTP binding
D172_RS12035	COG5001	Diguanylate cyclase
D172_RS12035	COG3300	MHYT domain
D172_RS12040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D172_RS12045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D172_RS12050	COG1702	phosphate starvation-inducible protein PhoH
D172_RS12055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D172_RS12060	COG4535	Mg2 and Co2 transporter CorC
D172_RS12065	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D172_RS12110	COG0534	Mate efflux family protein
D172_RS12135	COG0545	Peptidyl-prolyl cis-trans isomerase
D172_RS12140	COG1067	ATP-dependent peptidase activity
D172_RS12145	COG2888	peptidyl-tyrosine sulfation
D172_RS12150	COG0495	leucyl-tRNA aminoacylation
D172_RS12165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D172_RS12170	COG0799	negative regulation of ribosome biogenesis
D172_RS12175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D172_RS12180	COG0768	penicillin binding
D172_RS12185	COG0772	Belongs to the SEDS family
D172_RS12190	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D172_RS12195	COG1686	Belongs to the peptidase S11 family
D172_RS12200	COG2921	Belongs to the UPF0250 family
D172_RS12205	COG0321	lipoyl(octanoyl) transferase activity
D172_RS12210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D172_RS12220	COG0724	RNA recognition motif
D172_RS12240	COG2801	Transposase and inactivated derivatives
D172_RS12280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D172_RS12365	COG1320	monovalent cation:proton antiporter activity
D172_RS12370	COG2212	antiporter activity
D172_RS12375	COG1863	multisubunit Na H antiporter MnhE subunit
D172_RS12380	COG0651	ATP synthesis coupled electron transport
D172_RS12385	COG1006	Multisubunit Na H antiporter MnhC subunit
D172_RS12390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D172_RS12390	COG2111	Na H antiporter
D172_RS12405	COG1185	polyribonucleotide nucleotidyltransferase activity
D172_RS12410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D172_RS12415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D172_RS12420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D172_RS12425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D172_RS12430	COG0195	Participates in both transcription termination and antitermination
D172_RS12435	COG0779	Required for maturation of 30S ribosomal subunits
D172_RS12450	COG3046	protein related to deoxyribodipyrimidine photolyase
D172_RS12475	COG0450	alkyl hydroperoxide reductase
D172_RS12480	COG2801	Transposase and inactivated derivatives
D172_RS12500	COG3344	reverse transcriptase
D172_RS12515	COG3344	reverse transcriptase
D172_RS12520	COG2801	Transposase and inactivated derivatives
D172_RS12570	COG0037	tRNA processing
D172_RS12575	COG0825	malonyl-CoA metabolic process
D172_RS12580	COG0587	DNA-directed DNA polymerase activity
D172_RS12585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D172_RS12590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D172_RS12600	COG1294	oxidase, subunit
D172_RS12605	COG4890	Cyd operon protein YbgT
D172_RS12615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D172_RS12625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D172_RS12630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D172_RS12635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D172_RS12650	COG0750	zinc metalloprotease
D172_RS12665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D172_RS12670	COG0233	cytoplasmic translational termination
D172_RS12675	COG0528	UMP kinase activity
D172_RS12680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D172_RS12685	COG0052	Belongs to the universal ribosomal protein uS2 family
D172_RS12690	COG0024	Methionine aminopeptidase
D172_RS12695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D172_RS12700	COG2171	N-acyltransferase activity
D172_RS12715	COG2154	pterin-4-alpha-carbinolamine dehydratase
D172_RS12725	COG0626	cystathionine gamma-synthase activity
D172_RS12730	COG3768	UPF0283 membrane protein
D172_RS12735	COG3106	COG3106 Predicted ATPase
D172_RS12740	COG1983	PspC domain protein
D172_RS12750	COG1842	Phage shock protein A
D172_RS12755	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D172_RS12760	COG0747	negative chemotaxis
D172_RS12780	COG4172	Belongs to the ABC transporter superfamily
D172_RS12785	COG2514	catechol 2,3-dioxygenase activity
D172_RS12790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D172_RS12800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D172_RS12805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D172_RS12810	COG0740	serine-type endopeptidase activity
D172_RS12815	COG0544	peptidyl-prolyl cis-trans isomerase activity
D172_RS12845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D172_RS12850	COG0215	cysteine-tRNA ligase activity
D172_RS12855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D172_RS12880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D172_RS12885	COG1286	toxin biosynthetic process
D172_RS12895	COG0285	dihydrofolate synthase activity
D172_RS12900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D172_RS12905	COG0101	tRNA pseudouridine synthase activity
D172_RS12920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D172_RS12925	COG1250	3-hydroxyacyl-CoA dehydrogenase
D172_RS12925	COG1024	Enoyl-CoA hydratase
D172_RS12930	COG0183	Belongs to the thiolase family
D172_RS12935	COG0714	Associated with various cellular activities
D172_RS12950	COG2304	oxidoreductase activity
D172_RS12955	COG2304	oxidoreductase activity
D172_RS12965	COG1595	DNA-templated transcription, initiation
D172_RS12985	COG0519	Catalyzes the synthesis of GMP from XMP
D172_RS13030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D172_RS13035	COG0149	triose-phosphate isomerase activity
D172_RS13040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D172_RS13045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D172_RS13050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D172_RS13055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D172_RS13060	COG1534	Rna-binding protein
D172_RS13090	COG0745	RESPONSE REGULATOR receiver
D172_RS13095	COG2205	protein histidine kinase activity
D172_RS13100	COG0733	neurotransmitter:sodium symporter activity
D172_RS13105	COG2153	protein acetylation
D172_RS13110	COG4326	sporulation control protein
D172_RS13125	COG2205	protein histidine kinase activity
D172_RS13130	COG0745	RESPONSE REGULATOR receiver
D172_RS13145	COG3706	GGDEF domain
D172_RS13150	COG0583	DNA-binding transcription factor activity
D172_RS13155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D172_RS13160	COG0840	transmembrane signaling receptor activity
D172_RS13165	COG2827	Endonuclease containing a URI domain
D172_RS13170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D172_RS13175	COG2914	Belongs to the UPF0125 (RnfH) family
D172_RS13180	COG2867	negative regulation of translational initiation
D172_RS13185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D172_RS13190	COG4206	TonB-dependent receptor
D172_RS13195	COG0450	alkyl hydroperoxide reductase
D172_RS13205	COG2186	Transcriptional regulator
D172_RS13210	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D172_RS13215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D172_RS13225	COG1555	photosystem II stabilization
D172_RS13230	COG3141	response to X-ray
D172_RS13235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D172_RS13240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D172_RS13245	COG2853	Lipoprotein
D172_RS13265	COG1138	Cytochrome C-type biogenesis protein
D172_RS13270	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D172_RS13275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D172_RS13280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D172_RS13285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D172_RS13290	COG4133	protoheme IX ABC transporter activity
D172_RS13310	COG0835	chemotaxis
D172_RS13320	COG1192	Involved in chromosome partitioning
D172_RS13325	COG1360	Flagellar Motor Protein
D172_RS13330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D172_RS13335	COG2201	protein-glutamate methylesterase activity
D172_RS13340	COG0643	Histidine kinase
D172_RS13340	COG0784	Response regulator, receiver
D172_RS13340	COG2198	Histidine kinase
D172_RS13345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D172_RS13370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D172_RS13385	COG1987	bacterial-type flagellum assembly
D172_RS13395	COG3190	flagellar
D172_RS13410	COG1580	Controls the rotational direction of flagella during chemotaxis
D172_RS13415	COG3144	bacterial-type flagellum assembly
D172_RS13435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D172_RS13445	COG1677	Flagellar hook-basal body complex protein FliE
D172_RS13460	COG0519	Catalyzes the synthesis of GMP from XMP
D172_RS13480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D172_RS13485	COG1334	flagellar protein FlaG
D172_RS13510	COG1256	bacterial-type flagellum assembly
D172_RS13515	COG3951	Flagellar rod assembly protein muramidase FlgJ
D172_RS13515	COG1705	Flagellar rod assembly protein muramidase FlgJ
D172_RS13520	COG1706	bacterial-type flagellum-dependent cell motility
D172_RS13525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D172_RS13530	COG4786	Flagellar basal body rod
D172_RS13535	COG4787	bacterial-type flagellum-dependent cell motility
D172_RS13555	COG1815	bacterial-type flagellum-dependent cell motility
D172_RS13560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D172_RS13565	COG0835	chemotaxis
D172_RS13565	COG0784	Response regulator, receiver
D172_RS13600	COG0678	peroxiredoxin activity
D172_RS13600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D172_RS13670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D172_RS13675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D172_RS13680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D172_RS13685	COG0730	response to heat
D172_RS13690	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D172_RS13695	COG1051	belongs to the nudix hydrolase family
D172_RS13700	COG3066	DNA modification
D172_RS13705	COG0148	phosphopyruvate hydratase activity
D172_RS13710	COG0504	CTP synthase activity
D172_RS13715	COG3956	TIGRFAM MazG family protein
D172_RS13720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D172_RS13725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D172_RS13730	COG3437	response regulator, receiver
D172_RS13730	COG2205	protein histidine kinase activity
D172_RS13730	COG4999	Histidine kinase
D172_RS13730	COG3850	Histidine kinase
D172_RS13735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D172_RS13740	COG1381	Involved in DNA repair and RecF pathway recombination
D172_RS13750	COG0571	ribonuclease III activity
D172_RS13760	COG0481	GTPase activity
D172_RS13780	COG1595	DNA-templated transcription, initiation
D172_RS13785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D172_RS13795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D172_RS13800	COG0354	folic acid binding
D172_RS13805	COG1047	Peptidyl-prolyl cis-trans
D172_RS13820	COG3099	Belongs to the UPF0263 family
D172_RS13825	COG1024	Enoyl-CoA hydratase
D172_RS13825	COG1250	3-hydroxyacyl-CoA dehydrogenase
D172_RS13835	COG1346	cytolysis
D172_RS13840	COG0668	transmembrane transport
D172_RS13865	COG3409	Peptidoglycan-binding domain 1 protein
D172_RS13865	COG3267	Type II secretory pathway component ExeA
D172_RS13895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D172_RS13905	COG4206	TonB-dependent receptor
D172_RS13910	COG1666	GTP binding
D172_RS13925	COG0301	tRNA thio-modification
D172_RS13925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D172_RS13935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D172_RS13970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D172_RS13970	COG0165	Argininosuccinate lyase
D172_RS13975	COG0137	argininosuccinate synthase activity
D172_RS13985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D172_RS13990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D172_RS14000	COG0076	glutamate decarboxylase activity
D172_RS14005	COG2199	diguanylate cyclase activity
D172_RS14005	COG2200	EAL domain
D172_RS14005	COG3287	FIST C domain
D172_RS14010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D172_RS14015	COG0842	Transport permease protein
D172_RS14020	COG1131	(ABC) transporter
D172_RS14025	COG0163	prenyltransferase activity
D172_RS14030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D172_RS14035	COG1968	undecaprenyl-diphosphatase activity
D172_RS14040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D172_RS14050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D172_RS14055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D172_RS14075	COG0583	DNA-binding transcription factor activity
D172_RS14085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D172_RS14090	COG3161	chorismate lyase activity
D172_RS14135	COG2801	Transposase and inactivated derivatives
D172_RS14145	COG1580	Controls the rotational direction of flagella during chemotaxis
D172_RS14150	COG0705	Rhomboid family
D172_RS14155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D172_RS14160	COG1063	alcohol dehydrogenase
D172_RS14170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D172_RS14175	COG0859	PFAM glycosyl transferase family 9
D172_RS14180	COG3642	lipopolysaccharide core region biosynthetic process
D172_RS14200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D172_RS14200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D172_RS14205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D172_RS14210	COG1519	Transferase
D172_RS14220	COG3784	Protein of unknown function (DUF1318)
D172_RS14235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D172_RS14235	COG0047	phosphoribosylformylglycinamidine synthase activity
D172_RS14240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D172_RS14250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D172_RS14255	COG2066	Belongs to the glutaminase family
D172_RS14285	COG3118	belongs to the thioredoxin family
D172_RS14290	COG1473	amidohydrolase
D172_RS14295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D172_RS14310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D172_RS14315	COG1722	exodeoxyribonuclease VII activity
D172_RS14320	COG0142	geranyltranstransferase activity
D172_RS14325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D172_RS14330	COG3706	GGDEF domain
D172_RS14335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D172_RS14345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D172_RS14350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D172_RS14365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D172_RS14365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D172_RS14370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D172_RS14375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D172_RS14380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D172_RS14395	COG2201	protein-glutamate methylesterase activity
D172_RS14400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D172_RS14400	COG4191	Histidine kinase
D172_RS14405	COG2974	May be involved in recombination
D172_RS14415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D172_RS14420	COG1489	DNA binding
D172_RS14425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D172_RS14440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D172_RS14445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D172_RS14450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D172_RS14465	COG5002	protein histidine kinase activity
D172_RS14470	COG0745	RESPONSE REGULATOR receiver
D172_RS14480	COG0126	phosphoglycerate kinase activity
D172_RS14485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D172_RS14490	COG5001	Diguanylate cyclase
D172_RS14510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D172_RS14520	COG0784	Response regulator, receiver
D172_RS14520	COG2198	Histidine kinase
D172_RS14520	COG2205	protein histidine kinase activity
D172_RS14545	COG2199	diguanylate cyclase activity
D172_RS14565	COG1477	protein flavinylation
D172_RS14605	COG3250	beta-galactosidase activity
D172_RS14610	COG2259	Doxx family
D172_RS14615	COG1979	alcohol dehydrogenase
D172_RS14620	COG2207	Transcriptional regulator
D172_RS14670	COG1051	belongs to the nudix hydrolase family
D172_RS14700	COG2801	Transposase and inactivated derivatives
D172_RS14710	COG1668	transmembrane transport
D172_RS14715	COG4555	ABC transporter
D172_RS14725	COG2188	Transcriptional regulator
D172_RS14730	COG1131	(ABC) transporter
D172_RS14755	COG4771	TonB-dependent receptor
D172_RS14760	COG1858	cytochrome C peroxidase
D172_RS14770	COG1902	pentaerythritol trinitrate reductase activity
D172_RS14780	COG3791	Glutathione-dependent formaldehyde-activating
D172_RS14785	COG0753	catalase activity
D172_RS14790	COG0668	transmembrane transport
D172_RS14800	COG0754	glutathionylspermidine amidase activity
D172_RS14810	COG0783	Belongs to the Dps family
D172_RS14830	COG2197	response regulator
D172_RS14835	COG4585	Histidine kinase
D172_RS14845	COG0584	glycerophosphoryl diester phosphodiesterase
D172_RS14855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D172_RS14865	COG2205	protein histidine kinase activity
D172_RS14870	COG1247	-acetyltransferase
D172_RS14910	COG3954	Phosphoribulokinase
D172_RS14915	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D172_RS14920	COG1011	Hydrolase
D172_RS14925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D172_RS14935	COG0849	cell division
D172_RS14940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D172_RS14945	COG1181	Belongs to the D-alanine--D-alanine ligase family
D172_RS14950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D172_RS14955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D172_RS14960	COG0772	Belongs to the SEDS family
D172_RS14965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D172_RS14970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D172_RS14975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D172_RS14980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D172_RS14985	COG0768	penicillin binding
D172_RS14990	COG3116	cell division
D172_RS14995	COG0275	rRNA processing
D172_RS15000	COG2001	Belongs to the MraZ family
D172_RS15020	COG0435	Glutathione S-transferase
D172_RS15025	COG1741	Belongs to the pirin family
D172_RS15035	COG1295	ribonuclease BN
D172_RS15050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D172_RS15060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D172_RS15075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D172_RS15090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D172_RS15095	COG3128	pkhd-type hydroxylase
D172_RS15100	COG4774	siderophore transport
D172_RS15115	COG0811	peptide transport
D172_RS15120	COG0848	biopolymer transport protein
D172_RS15135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D172_RS15140	COG1187	pseudouridine synthase activity
D172_RS15155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D172_RS15170	COG2897	thiosulfate sulfurtransferase activity
D172_RS15175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D172_RS15195	COG3300	MHYT domain
D172_RS15195	COG5001	Diguanylate cyclase
D172_RS15205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D172_RS15210	COG4181	ATPase activity
D172_RS15230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D172_RS15235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D172_RS15235	COG0678	peroxiredoxin activity
D172_RS15250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D172_RS15275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D172_RS15315	COG2089	acid synthase
D172_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
D172_RS15330	COG0667	Aldo Keto reductase
D172_RS15335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D172_RS15340	COG1086	Polysaccharide biosynthesis protein
D172_RS15350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D172_RS15355	COG1596	polysaccharide export
D172_RS15370	COG0438	transferase activity, transferring glycosyl groups
D172_RS15390	COG0110	maltose O-acetyltransferase activity
D172_RS15415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D172_RS15425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D172_RS15440	COG3137	Salt-induced outer membrane protein
D172_RS15445	COG0668	transmembrane transport
D172_RS15470	COG1234	tRNA 3'-trailer cleavage
D172_RS15480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D172_RS15500	COG0443	Heat shock 70 kDa protein
D172_RS15505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D172_RS15510	COG0316	Belongs to the HesB IscA family
D172_RS15515	COG0822	iron-sulfur transferase activity
D172_RS15520	COG1104	cysteine desulfurase activity
D172_RS15530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D172_RS15535	COG1609	Transcriptional regulator
D172_RS15545	COG1621	beta-fructofuranosidase activity
D172_RS15550	COG2814	Major facilitator Superfamily
D172_RS15555	COG0702	epimerase
D172_RS15560	COG4771	TonB-dependent receptor
D172_RS15565	COG0742	ribosomal rna small subunit methyltransferase
D172_RS15570	COG0745	RESPONSE REGULATOR receiver
D172_RS15575	COG0339	signal peptide processing
D172_RS15585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D172_RS15730	COG0312	modulator of DNA gyrase
D172_RS15735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D172_RS15740	COG3164	Protein of unknown function
D172_RS15745	COG1530	ribonuclease E activity
D172_RS15750	COG0424	maF-like protein
D172_RS15755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D172_RS15760	COG1792	Involved in formation and maintenance of cell shape
D172_RS15765	COG1077	Cell shape determining protein MreB Mrl
D172_RS15775	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D172_RS15785	COG0784	Response regulator, receiver
D172_RS15785	COG2205	protein histidine kinase activity
D172_RS15790	COG0629	single-stranded DNA binding
D172_RS15795	COG2814	Major facilitator Superfamily
D172_RS15800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D172_RS15805	COG0745	RESPONSE REGULATOR receiver
D172_RS15820	COG0180	Tryptophanyl-tRNA synthetase
D172_RS15830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D172_RS15840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D172_RS15845	COG3266	domain, Protein
D172_RS15850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D172_RS15855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D172_RS15885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D172_RS15890	COG0527	aspartate kinase activity
D172_RS15890	COG0460	homoserine dehydrogenase
D172_RS15895	COG0626	cystathionine gamma-synthase activity
D172_RS15900	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D172_RS15905	COG0281	malic enzyme
D172_RS15910	COG0254	rRNA binding
D172_RS15915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D172_RS15925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D172_RS15930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D172_RS15950	COG0671	phosphoesterase, PA-phosphatase related
D172_RS15955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D172_RS15970	COG1228	amidohydrolase
D172_RS15980	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D172_RS15990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D172_RS15995	COG0653	protein targeting
D172_RS16000	COG0494	nUDIX hydrolase
D172_RS16010	COG3590	peptidase
D172_RS16020	COG0312	modulator of DNA gyrase
D172_RS16050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D172_RS16065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D172_RS16065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D172_RS16070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D172_RS16095	COG0702	epimerase
D172_RS16100	COG0288	reversible hydration of carbon dioxide
D172_RS16120	COG0129	dihydroxy-acid dehydratase activity
D172_RS16135	COG2194	sulfuric ester hydrolase activity
D172_RS16140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D172_RS16145	COG1368	sulfuric ester hydrolase activity
D172_RS16200	COG0203	ribosomal protein L17
D172_RS16205	COG0202	RNA polymerase activity
D172_RS16210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D172_RS16215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D172_RS16220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D172_RS16225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D172_RS16230	COG0201	protein transport
D172_RS16235	COG0200	Binds to the 23S rRNA
D172_RS16240	COG1841	ribosomal large subunit assembly
D172_RS16245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D172_RS16250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D172_RS16255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D172_RS16260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D172_RS16265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D172_RS16270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D172_RS16275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D172_RS16280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D172_RS16325	COG4555	ABC transporter
D172_RS16335	COG0640	Transcriptional regulator
D172_RS16385	COG1132	(ABC) transporter
D172_RS16405	COG0668	transmembrane transport
D172_RS16410	COG0204	Acyl-transferase
D172_RS16415	COG0204	Acyl-transferase
D172_RS16420	COG1166	arginine decarboxylase activity
D172_RS16425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D172_RS16445	COG1082	Xylose isomerase domain protein TIM barrel
D172_RS16455	COG0644	oxidoreductase
D172_RS16475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D172_RS16490	COG2183	response to ionizing radiation
D172_RS16510	COG1040	competence protein
D172_RS16520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D172_RS16520	COG0316	Belongs to the HesB IscA family
D172_RS16530	COG0534	Mate efflux family protein
D172_RS16535	COG0726	polysaccharide deacetylase
D172_RS16540	COG2201	protein-glutamate methylesterase activity
D172_RS16545	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D172_RS16560	COG0835	chemotaxis
D172_RS16565	COG2198	Histidine kinase
D172_RS16565	COG0643	Histidine kinase
D172_RS16570	COG0745	RESPONSE REGULATOR receiver
D172_RS16585	COG0109	protoheme IX farnesyltransferase activity
D172_RS16610	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D172_RS16625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D172_RS16630	COG3291	Pkd domain containing protein
D172_RS16655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D172_RS16655	COG1017	nitric oxide dioxygenase activity
D172_RS16665	COG3604	Transcriptional regulator
D172_RS16670	COG0583	DNA-binding transcription factor activity
D172_RS16675	COG0431	NADPH-dependent FMN reductase
D172_RS16705	COG0066	3-isopropylmalate dehydratase activity
D172_RS16710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D172_RS16715	COG0473	3-isopropylmalate dehydrogenase activity
D172_RS16720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D172_RS16735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D172_RS16740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D172_RS16745	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D172_RS16750	COG0545	Peptidyl-prolyl cis-trans isomerase
D172_RS16760	COG2900	Belongs to the SlyX family
D172_RS16765	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D172_RS16770	COG0488	(ABC) transporter
D172_RS16780	COG0429	hydrolase of the alpha beta-hydrolase fold
D172_RS16785	COG3089	Belongs to the UPF0270 family
D172_RS16795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D172_RS16820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D172_RS16830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D172_RS16845	COG0537	adenosine 5'-monophosphoramidase activity
D172_RS16890	COG0436	Aminotransferase
D172_RS16895	COG0235	Class ii aldolase
D172_RS16900	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D172_RS16910	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D172_RS16915	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D172_RS16920	COG0069	glutamate synthase activity
D172_RS16935	COG2226	methyltransferase
D172_RS16950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D172_RS16955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D172_RS16960	COG0805	protein transport
D172_RS16975	COG5001	Diguanylate cyclase
D172_RS16975	COG4251	negative regulation of phosphorylation
D172_RS16975	COG3706	GGDEF domain
D172_RS16975	COG2203	Gaf domain
D172_RS16990	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D172_RS16995	COG2943	transferase activity, transferring hexosyl groups
D172_RS16995	COG3416	Protein conserved in bacteria
D172_RS17000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D172_RS17050	COG4681	YaeQ
D172_RS17065	COG0783	Belongs to the Dps family
D172_RS17070	COG4206	TonB-dependent receptor
D172_RS17085	COG1770	oligopeptidase
D172_RS17090	COG3397	chitin binding
D172_RS17100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D172_RS17110	COG0386	Belongs to the glutathione peroxidase family
D172_RS17125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D172_RS17150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D172_RS17160	COG1522	sequence-specific DNA binding
D172_RS17165	COG4999	Histidine kinase
D172_RS17165	COG3437	response regulator, receiver
D172_RS17165	COG2205	protein histidine kinase activity
D172_RS17165	COG3850	Histidine kinase
D172_RS17235	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D172_RS17315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D172_RS17315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D172_RS17345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D172_RS17420	COG0751	glycine-tRNA ligase activity
D172_RS17445	COG0187	DNA topoisomerase II activity
D172_RS17520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D172_RS17535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D172_RS17710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D172_RS18130	COG0181	hydroxymethylbilane synthase activity
D172_RS18435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D172_RS18530	COG0019	diaminopimelate decarboxylase activity
D172_RS18930	COG0745	RESPONSE REGULATOR receiver
D172_RS18930	COG2205	protein histidine kinase activity
D172_RS18930	COG3292	Two component regulator propeller
D172_RS18955	COG0085	RNA polymerase activity
D172_RS19220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D172_RS19355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D172_RS19660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D172_RS19760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D172_RS19785	COG1404	Belongs to the peptidase S8 family
D172_RS19875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D172_RS20160	COG0187	DNA topoisomerase II activity
D172_RS20370	COG1757	Na H antiporter
D172_RS20455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D172_RS20465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D172_RS20820	COG3107	peptidoglycan biosynthetic process