locus-tag	class	description
B1F84_RS00010	COG0592	DNA-directed DNA polymerase activity
B1F84_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1F84_RS00020	COG0187	DNA topoisomerase II activity
B1F84_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
B1F84_RS00030	COG0751	glycine-tRNA ligase activity
B1F84_RS00045	COG0425	Belongs to the sulfur carrier protein TusA family
B1F84_RS00050	COG0183	Belongs to the thiolase family
B1F84_RS00055	COG1024	Enoyl-CoA hydratase
B1F84_RS00055	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1F84_RS00060	COG0741	lytic transglycosylase activity
B1F84_RS00065	COG0006	proline dipeptidase activity
B1F84_RS00070	COG1739	Uncharacterized protein family UPF0029
B1F84_RS00075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1F84_RS00110	COG0569	domain protein
B1F84_RS00115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1F84_RS00115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1F84_RS00120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1F84_RS00125	COG0242	peptide deformylase activity
B1F84_RS00135	COG0758	DNA mediated transformation
B1F84_RS00140	COG2922	Belongs to the Smg family
B1F84_RS00150	COG0009	L-threonylcarbamoyladenylate synthase
B1F84_RS00155	COG0408	coproporphyrinogen oxidase activity
B1F84_RS00165	COG2346	COG2346, Truncated hemoglobins
B1F84_RS00170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1F84_RS00180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B1F84_RS00220	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1F84_RS00280	COG2205	protein histidine kinase activity
B1F84_RS00280	COG0784	Response regulator, receiver
B1F84_RS00285	COG1522	sequence-specific DNA binding
B1F84_RS00335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B1F84_RS00365	COG1770	oligopeptidase
B1F84_RS00375	COG1238	metal cluster binding
B1F84_RS00380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1F84_RS00385	COG0302	gtp cyclohydrolase
B1F84_RS00395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1F84_RS00400	COG3132	Protein of unknown function, DUF480
B1F84_RS00405	COG5002	protein histidine kinase activity
B1F84_RS00405	COG0784	Response regulator, receiver
B1F84_RS00405	COG2205	protein histidine kinase activity
B1F84_RS00410	COG1944	ATP diphosphatase activity
B1F84_RS00420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1F84_RS00425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F84_RS00425	COG3153	acetyltransferase
B1F84_RS00455	COG1187	pseudouridine synthase activity
B1F84_RS00475	COG1011	Hydrolase
B1F84_RS00480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B1F84_RS00490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1F84_RS00495	COG0019	diaminopimelate decarboxylase activity
B1F84_RS00505	COG1965	Belongs to the frataxin family
B1F84_RS00520	COG0181	hydroxymethylbilane synthase activity
B1F84_RS00525	COG2959	enzyme of heme biosynthesis
B1F84_RS00540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1F84_RS00555	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1F84_RS00630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1F84_RS00665	COG4774	siderophore transport
B1F84_RS00670	COG0513	Belongs to the DEAD box helicase family
B1F84_RS00680	COG0784	Response regulator, receiver
B1F84_RS00680	COG5002	protein histidine kinase activity
B1F84_RS00680	COG2205	protein histidine kinase activity
B1F84_RS00690	COG3118	belongs to the thioredoxin family
B1F84_RS00700	COG0248	Ppx GppA phosphatase
B1F84_RS00730	COG1444	tRNA N-acetyltransferase activity
B1F84_RS00735	COG0210	DNA helicase
B1F84_RS00745	COG3112	Uncharacterised protein family (UPF0231)
B1F84_RS00755	COG1011	Hydrolase
B1F84_RS00760	COG0494	nUDIX hydrolase
B1F84_RS00765	COG1218	3'(2'),5'-bisphosphate nucleotidase
B1F84_RS00790	COG0606	chelatase, subunit chli
B1F84_RS00800	COG0823	Involved in the tonB-independent uptake of proteins
B1F84_RS00800	COG1506	peptidase
B1F84_RS00805	COG1253	flavin adenine dinucleotide binding
B1F84_RS00810	COG2202	Pas domain
B1F84_RS00810	COG2199	diguanylate cyclase activity
B1F84_RS00810	COG2200	EAL domain
B1F84_RS00825	COG2031	fatty acid transporter
B1F84_RS00830	COG0784	Response regulator, receiver
B1F84_RS00830	COG0835	chemotaxis
B1F84_RS00855	COG1946	Acyl-CoA thioesterase
B1F84_RS00860	COG2937	Belongs to the GPAT DAPAT family
B1F84_RS00865	COG0051	transcription antitermination factor activity, RNA binding
B1F84_RS00870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1F84_RS00875	COG0088	Forms part of the polypeptide exit tunnel
B1F84_RS00880	COG0089	rRNA binding
B1F84_RS00885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1F84_RS00890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1F84_RS00895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1F84_RS00900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1F84_RS00905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1F84_RS00910	COG0255	Belongs to the universal ribosomal protein uL29 family
B1F84_RS00915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1F84_RS00930	COG2356	endonuclease I
B1F84_RS00940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1F84_RS00960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1F84_RS00995	COG3852	Histidine kinase
B1F84_RS01005	COG0174	glutamine synthetase
B1F84_RS01010	COG1217	gtp-binding protein TYPA
B1F84_RS01035	COG1295	ribonuclease BN
B1F84_RS01040	COG1490	D-aminoacyl-tRNA deacylase activity
B1F84_RS01050	COG0456	acetyltransferase
B1F84_RS01055	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
B1F84_RS01065	COG0019	diaminopimelate decarboxylase activity
B1F84_RS01075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1F84_RS01085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B1F84_RS01095	COG1049	propionate catabolic process, 2-methylcitrate cycle
B1F84_RS01105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1F84_RS01145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1F84_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
B1F84_RS01165	COG1765	OsmC-like protein
B1F84_RS01170	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B1F84_RS01180	COG0814	amino acid
B1F84_RS01185	COG2267	carboxylic ester hydrolase activity
B1F84_RS01190	COG1218	3'(2'),5'-bisphosphate nucleotidase
B1F84_RS01195	COG0529	Catalyzes the synthesis of activated sulfate
B1F84_RS01200	COG0471	metal ion transport
B1F84_RS01200	COG3273	potassium ion transport
B1F84_RS01205	COG2895	sulfate adenylyltransferase (ATP) activity
B1F84_RS01210	COG0175	sulfate reduction
B1F84_RS01215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1F84_RS01215	COG1648	precorrin-2 dehydrogenase activity
B1F84_RS01220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B1F84_RS01235	COG3292	Two component regulator propeller
B1F84_RS01235	COG0745	RESPONSE REGULATOR receiver
B1F84_RS01235	COG2205	protein histidine kinase activity
B1F84_RS01245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1F84_RS01250	COG0250	Participates in transcription elongation, termination and antitermination
B1F84_RS01255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1F84_RS01260	COG0081	regulation of translation
B1F84_RS01265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1F84_RS01270	COG0222	ribosome binding
B1F84_RS01275	COG0085	RNA polymerase activity
B1F84_RS01280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1F84_RS01285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1F84_RS01290	COG0049	tRNA binding
B1F84_RS01295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1F84_RS01300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1F84_RS01315	COG0784	Response regulator, receiver
B1F84_RS01315	COG2205	protein histidine kinase activity
B1F84_RS01320	COG1119	ATPase activity
B1F84_RS01335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B1F84_RS01340	COG2194	sulfuric ester hydrolase activity
B1F84_RS01355	COG0129	dihydroxy-acid dehydratase activity
B1F84_RS01360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1F84_RS01375	COG0288	reversible hydration of carbon dioxide
B1F84_RS01405	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B1F84_RS01410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1F84_RS01410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1F84_RS01425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B1F84_RS01435	COG3078	GTPase activator activity
B1F84_RS01455	COG0312	modulator of DNA gyrase
B1F84_RS01465	COG3590	peptidase
B1F84_RS01470	COG0494	nUDIX hydrolase
B1F84_RS01475	COG0653	protein targeting
B1F84_RS01485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1F84_RS01490	COG2986	histidine ammonia-lyase
B1F84_RS01495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B1F84_RS01505	COG1228	amidohydrolase
B1F84_RS01520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1F84_RS01535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B1F84_RS01540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B1F84_RS01545	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B1F84_RS01550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1F84_RS01555	COG0254	rRNA binding
B1F84_RS01560	COG0281	malic enzyme
B1F84_RS01565	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
B1F84_RS01570	COG0626	cystathionine gamma-synthase activity
B1F84_RS01575	COG0460	homoserine dehydrogenase
B1F84_RS01575	COG0527	aspartate kinase activity
B1F84_RS01580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B1F84_RS01610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1F84_RS01615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1F84_RS01625	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B1F84_RS01660	COG0732	type I restriction modification DNA specificity domain
B1F84_RS01670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1F84_RS01730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B1F84_RS01745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1F84_RS01755	COG0180	Tryptophanyl-tRNA synthetase
B1F84_RS01770	COG0745	RESPONSE REGULATOR receiver
B1F84_RS01780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1F84_RS01785	COG2814	Major facilitator Superfamily
B1F84_RS01790	COG0629	single-stranded DNA binding
B1F84_RS01800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B1F84_RS01805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1F84_RS01810	COG1077	Cell shape determining protein MreB Mrl
B1F84_RS01815	COG1792	Involved in formation and maintenance of cell shape
B1F84_RS01820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B1F84_RS01825	COG0424	maF-like protein
B1F84_RS01830	COG1530	ribonuclease E activity
B1F84_RS01835	COG3164	Protein of unknown function
B1F84_RS01840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F84_RS01845	COG0312	modulator of DNA gyrase
B1F84_RS01860	COG4181	ATPase activity
B1F84_RS01870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1F84_RS01880	COG5001	Diguanylate cyclase
B1F84_RS01880	COG3300	MHYT domain
B1F84_RS01895	COG3306	glycosyltransferase involved in LPS biosynthesis
B1F84_RS01915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B1F84_RS01930	COG1187	pseudouridine synthase activity
B1F84_RS01935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B1F84_RS01940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1F84_RS01960	COG1509	lysine 2,3-aminomutase activity
B1F84_RS01965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1F84_RS01970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B1F84_RS01975	COG4774	siderophore transport
B1F84_RS01975	COG1629	transport
B1F84_RS01990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1F84_RS02005	COG2022	thiamine diphosphate biosynthetic process
B1F84_RS02015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B1F84_RS02020	COG0688	phosphatidylethanolamine metabolic process
B1F84_RS02030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B1F84_RS02050	COG0432	Pfam Uncharacterised protein family UPF0047
B1F84_RS02060	COG0735	belongs to the Fur family
B1F84_RS02065	COG2095	MarC family integral membrane protein
B1F84_RS02075	COG1842	Phage shock protein A
B1F84_RS02090	COG2847	Copper chaperone PCu(A)C
B1F84_RS02115	COG1032	radical SAM domain protein
B1F84_RS02120	COG2239	Acts as a magnesium transporter
B1F84_RS02125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1F84_RS02130	COG1660	Displays ATPase and GTPase activities
B1F84_RS02135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1F84_RS02145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B1F84_RS02150	COG1137	ATPase activity
B1F84_RS02165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B1F84_RS02170	COG0517	IMP dehydrogenase activity
B1F84_RS02170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B1F84_RS02180	COG1127	ABC transporter
B1F84_RS02185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1F84_RS02190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1F84_RS02195	COG2854	intermembrane phospholipid transfer
B1F84_RS02200	COG3113	response to antibiotic
B1F84_RS02205	COG5007	Belongs to the BolA IbaG family
B1F84_RS02210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1F84_RS02220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1F84_RS02230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B1F84_RS02240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1F84_RS02245	COG0339	signal peptide processing
B1F84_RS02255	COG0742	ribosomal rna small subunit methyltransferase
B1F84_RS02275	COG1104	cysteine desulfurase activity
B1F84_RS02280	COG0822	iron-sulfur transferase activity
B1F84_RS02285	COG0316	Belongs to the HesB IscA family
B1F84_RS02290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1F84_RS02295	COG0443	Heat shock 70 kDa protein
B1F84_RS02310	COG0840	transmembrane signaling receptor activity
B1F84_RS02315	COG3300	MHYT domain
B1F84_RS02315	COG5001	Diguanylate cyclase
B1F84_RS02320	COG2205	protein histidine kinase activity
B1F84_RS02325	COG0745	RESPONSE REGULATOR receiver
B1F84_RS02340	COG1404	Belongs to the peptidase S8 family
B1F84_RS02355	COG0668	transmembrane transport
B1F84_RS02360	COG3137	Salt-induced outer membrane protein
B1F84_RS02380	COG1086	Polysaccharide biosynthesis protein
B1F84_RS02385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1F84_RS02390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1F84_RS02395	COG2089	acid synthase
B1F84_RS02410	COG1083	cytidylyl-transferase
B1F84_RS02455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1F84_RS02465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1F84_RS02470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1F84_RS02480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1F84_RS02485	COG3550	peptidyl-serine autophosphorylation
B1F84_RS02500	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1F84_RS02510	COG1227	inorganic diphosphatase activity
B1F84_RS02520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1F84_RS02535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1F84_RS02540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1F84_RS02550	COG0723	plastoquinol--plastocyanin reductase activity
B1F84_RS02555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1F84_RS02560	COG2857	Cytochrome c1
B1F84_RS02565	COG0625	glutathione transferase activity
B1F84_RS02570	COG2969	positive regulation of protein catabolic process
B1F84_RS02575	COG2823	Periplasmic or secreted lipoprotein
B1F84_RS02580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1F84_RS02585	COG0792	nuclease activity
B1F84_RS02590	COG3107	peptidoglycan biosynthetic process
B1F84_RS02595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B1F84_RS02610	COG1295	ribonuclease BN
B1F84_RS02620	COG1741	Belongs to the pirin family
B1F84_RS02640	COG2001	Belongs to the MraZ family
B1F84_RS02645	COG0275	rRNA processing
B1F84_RS02655	COG0768	penicillin binding
B1F84_RS02660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1F84_RS02665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1F84_RS02670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1F84_RS02675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1F84_RS02680	COG0772	Belongs to the SEDS family
B1F84_RS02685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1F84_RS02690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1F84_RS02695	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1F84_RS02700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B1F84_RS02705	COG0849	cell division
B1F84_RS02710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1F84_RS02715	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B1F84_RS02720	COG1011	Hydrolase
B1F84_RS02730	COG3954	Phosphoribulokinase
B1F84_RS02760	COG0625	glutathione transferase activity
B1F84_RS02775	COG1247	-acetyltransferase
B1F84_RS02780	COG2198	Histidine kinase
B1F84_RS02780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F84_RS02780	COG0784	Response regulator, receiver
B1F84_RS02780	COG2205	protein histidine kinase activity
B1F84_RS02795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B1F84_RS02805	COG0584	glycerophosphoryl diester phosphodiesterase
B1F84_RS02820	COG0557	exoribonuclease II activity
B1F84_RS02825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1F84_RS02830	COG4774	siderophore transport
B1F84_RS02835	COG0583	DNA-binding transcription factor activity
B1F84_RS02845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1F84_RS02850	COG0509	glycine decarboxylation via glycine cleavage system
B1F84_RS02855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1F84_RS02855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1F84_RS02890	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
B1F84_RS02905	COG3706	GGDEF domain
B1F84_RS02910	COG0840	transmembrane signaling receptor activity
B1F84_RS02915	COG1228	amidohydrolase
B1F84_RS02930	COG0840	transmembrane signaling receptor activity
B1F84_RS02945	COG0625	glutathione transferase activity
B1F84_RS02950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1F84_RS02960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1F84_RS02975	COG2137	regulation of response to DNA damage stimulus
B1F84_RS02980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1F84_RS02990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1F84_RS03010	COG3630	sodium ion export across plasma membrane
B1F84_RS03025	COG4989	oxidoreductase activity
B1F84_RS03035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1F84_RS03045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1F84_RS03055	COG1469	GTP cyclohydrolase I activity
B1F84_RS03060	COG0784	Response regulator, receiver
B1F84_RS03060	COG5002	protein histidine kinase activity
B1F84_RS03060	COG2198	Histidine kinase
B1F84_RS03065	COG0745	RESPONSE REGULATOR receiver
B1F84_RS03070	COG4191	Histidine kinase
B1F84_RS03075	COG2813	Specifically methylates the guanine in position
B1F84_RS03080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1F84_RS03085	COG1194	a g-specific adenine glycosylase
B1F84_RS03090	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B1F84_RS03095	COG2205	protein histidine kinase activity
B1F84_RS03095	COG0784	Response regulator, receiver
B1F84_RS03095	COG5002	protein histidine kinase activity
B1F84_RS03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F84_RS03145	COG3079	Belongs to the UPF0149 family
B1F84_RS03150	COG0006	proline dipeptidase activity
B1F84_RS03155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1F84_RS03160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1F84_RS03175	COG0360	Binds together with S18 to 16S ribosomal RNA
B1F84_RS03180	COG2965	DNA replication, synthesis of RNA primer
B1F84_RS03185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1F84_RS03190	COG0359	binds to the 23S rRNA
B1F84_RS03200	COG4968	Prepilin-type N-terminal cleavage methylation domain
B1F84_RS03220	COG1595	DNA-templated transcription, initiation
B1F84_RS03235	COG0305	Participates in initiation and elongation during chromosome replication
B1F84_RS03240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1F84_RS03275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B1F84_RS03290	COG0525	valine-tRNA ligase activity
B1F84_RS03295	COG2927	DNA polymerase III (CHI subunit)
B1F84_RS03300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1F84_RS03305	COG0795	lipopolysaccharide-transporting ATPase activity
B1F84_RS03310	COG0795	lipopolysaccharide-transporting ATPase activity
B1F84_RS03335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1F84_RS03340	COG1283	sodium-dependent phosphate transmembrane transporter activity
B1F84_RS03370	COG1012	belongs to the aldehyde dehydrogenase family
B1F84_RS03395	COG2204	response regulator
B1F84_RS03405	COG4251	negative regulation of phosphorylation
B1F84_RS03410	COG0784	Response regulator, receiver
B1F84_RS03415	COG0784	Response regulator, receiver
B1F84_RS03415	COG2198	Histidine kinase
B1F84_RS03415	COG5002	protein histidine kinase activity
B1F84_RS03420	COG1609	Transcriptional regulator
B1F84_RS03425	COG2211	Major facilitator Superfamily
B1F84_RS03445	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1F84_RS03455	COG0667	Aldo Keto reductase
B1F84_RS03465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F84_RS03505	COG2974	May be involved in recombination
B1F84_RS03510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F84_RS03510	COG4191	Histidine kinase
B1F84_RS03515	COG2201	protein-glutamate methylesterase activity
B1F84_RS03530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1F84_RS03535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1F84_RS03540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1F84_RS03545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1F84_RS03545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1F84_RS03560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1F84_RS03565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1F84_RS03580	COG3706	GGDEF domain
B1F84_RS03585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1F84_RS03590	COG0142	geranyltranstransferase activity
B1F84_RS03595	COG1722	exodeoxyribonuclease VII activity
B1F84_RS03600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1F84_RS03605	COG2885	chlorophyll binding
B1F84_RS03615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1F84_RS03620	COG1473	amidohydrolase
B1F84_RS03625	COG3118	belongs to the thioredoxin family
B1F84_RS03650	COG2066	Belongs to the glutaminase family
B1F84_RS03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1F84_RS03665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B1F84_RS03670	COG0047	phosphoribosylformylglycinamidine synthase activity
B1F84_RS03670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1F84_RS03685	COG3784	Protein of unknown function (DUF1318)
B1F84_RS03695	COG1519	Transferase
B1F84_RS03700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1F84_RS03705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1F84_RS03705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1F84_RS03720	COG0438	transferase activity, transferring glycosyl groups
B1F84_RS03725	COG3642	lipopolysaccharide core region biosynthetic process
B1F84_RS03730	COG0859	PFAM glycosyl transferase family 9
B1F84_RS03735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1F84_RS03745	COG1063	alcohol dehydrogenase
B1F84_RS03750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1F84_RS03755	COG0705	Rhomboid family
B1F84_RS03760	COG1580	Controls the rotational direction of flagella during chemotaxis
B1F84_RS03765	COG3161	chorismate lyase activity
B1F84_RS03770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B1F84_RS03780	COG0583	DNA-binding transcription factor activity
B1F84_RS03800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1F84_RS03805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1F84_RS03810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1F84_RS03820	COG1968	undecaprenyl-diphosphatase activity
B1F84_RS03825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1F84_RS03830	COG0163	prenyltransferase activity
B1F84_RS03835	COG1131	(ABC) transporter
B1F84_RS03840	COG0842	Transport permease protein
B1F84_RS03845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1F84_RS03855	COG0076	glutamate decarboxylase activity
B1F84_RS03865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1F84_RS03880	COG0137	argininosuccinate synthase activity
B1F84_RS03885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1F84_RS03885	COG0165	Argininosuccinate lyase
B1F84_RS03915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1F84_RS03925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1F84_RS03925	COG0301	tRNA thio-modification
B1F84_RS03930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1F84_RS03940	COG1666	GTP binding
B1F84_RS03945	COG4206	TonB-dependent receptor
B1F84_RS03955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F84_RS03985	COG3409	Peptidoglycan-binding domain 1 protein
B1F84_RS03985	COG3267	Type II secretory pathway component ExeA
B1F84_RS04000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B1F84_RS04000	COG0506	proline dehydrogenase activity
B1F84_RS04000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B1F84_RS04005	COG1522	sequence-specific DNA binding
B1F84_RS04010	COG4991	sh3 domain protein
B1F84_RS04015	COG3025	triphosphatase activity
B1F84_RS04030	COG0745	RESPONSE REGULATOR receiver
B1F84_RS04040	COG0004	ammonium transporteR
B1F84_RS04045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1F84_RS04050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1F84_RS04055	COG0540	Belongs to the ATCase OTCase family
B1F84_RS04060	COG1981	membrane
B1F84_RS04070	COG0316	Belongs to the HesB IscA family
B1F84_RS04085	COG2211	Major facilitator Superfamily
B1F84_RS04100	COG2813	Specifically methylates the guanine in position
B1F84_RS04110	COG0271	Belongs to the BolA IbaG family
B1F84_RS04115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B1F84_RS04120	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1F84_RS04125	COG1805	sodium ion transport
B1F84_RS04130	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1F84_RS04135	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1F84_RS04140	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B1F84_RS04145	COG2871	sodium ion transport
B1F84_RS04150	COG1477	protein flavinylation
B1F84_RS04155	COG2991	Protein conserved in bacteria
B1F84_RS04165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1F84_RS04185	COG0109	protoheme IX farnesyltransferase activity
B1F84_RS04195	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1F84_RS04205	COG0488	(ABC) transporter
B1F84_RS04210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B1F84_RS04215	COG1410	methionine synthase
B1F84_RS04215	COG0646	methionine synthase
B1F84_RS04220	COG1410	methionine synthase
B1F84_RS04220	COG0646	methionine synthase
B1F84_RS04230	COG1794	racemase activity, acting on amino acids and derivatives
B1F84_RS04240	COG3237	CsbD-like
B1F84_RS04265	COG1815	bacterial-type flagellum-dependent cell motility
B1F84_RS04270	COG1558	bacterial-type flagellum-dependent cell motility
B1F84_RS04280	COG1749	Flagellar hook protein flgE
B1F84_RS04285	COG4787	bacterial-type flagellum-dependent cell motility
B1F84_RS04290	COG4786	Flagellar basal body rod
B1F84_RS04300	COG1706	bacterial-type flagellum-dependent cell motility
B1F84_RS04325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1F84_RS04330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B1F84_RS04355	COG1191	sigma factor activity
B1F84_RS04360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1F84_RS04365	COG1360	Flagellar Motor Protein
B1F84_RS04390	COG1987	bacterial-type flagellum assembly
B1F84_RS04410	COG2885	chlorophyll binding
B1F84_RS04420	COG1677	Flagellar hook-basal body complex protein FliE
B1F84_RS04430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1F84_RS04450	COG1643	Atp-dependent helicase
B1F84_RS04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F84_RS04460	COG4191	Histidine kinase
B1F84_RS04465	COG2203	Gaf domain
B1F84_RS04465	COG4251	negative regulation of phosphorylation
B1F84_RS04465	COG3706	GGDEF domain
B1F84_RS04465	COG5001	Diguanylate cyclase
B1F84_RS04480	COG1064	alcohol dehydrogenase
B1F84_RS04485	COG2814	Major facilitator Superfamily
B1F84_RS04495	COG1476	TRANSCRIPTIONal
B1F84_RS04505	COG0583	DNA-binding transcription factor activity
B1F84_RS04525	COG2200	EAL domain
B1F84_RS04530	COG1764	response to oxidative stress
B1F84_RS04540	COG0415	Belongs to the DNA photolyase family
B1F84_RS04545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1F84_RS04555	COG0625	glutathione transferase activity
B1F84_RS04565	COG0693	protein deglycase activity
B1F84_RS04570	COG0583	DNA-binding transcription factor activity
B1F84_RS04595	COG0339	signal peptide processing
B1F84_RS04600	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B1F84_RS04600	COG3264	Mechanosensitive ion channel
B1F84_RS04605	COG4771	TonB-dependent receptor
B1F84_RS04615	COG1793	dna ligase
B1F84_RS04620	COG0443	Heat shock 70 kDa protein
B1F84_RS04625	COG1803	Methylglyoxal synthase
B1F84_RS04630	COG1280	lysine exporter protein (LysE YggA)
B1F84_RS04655	COG0739	heme binding
B1F84_RS04685	COG3047	cAMP biosynthetic process
B1F84_RS04690	COG0534	Mate efflux family protein
B1F84_RS04705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F84_RS04725	COG2201	protein-glutamate methylesterase activity
B1F84_RS04730	COG0268	Binds directly to 16S ribosomal RNA
B1F84_RS04735	COG0728	peptidoglycan biosynthetic process
B1F84_RS04740	COG0196	riboflavin kinase activity
B1F84_RS04745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1F84_RS04750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1F84_RS04755	COG1047	Peptidyl-prolyl cis-trans
B1F84_RS04760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1F84_RS04805	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1F84_RS04810	COG0564	pseudouridine synthase activity
B1F84_RS04820	COG0542	response to heat
B1F84_RS04825	COG0840	transmembrane signaling receptor activity
B1F84_RS04830	COG2918	glutathione biosynthetic process
B1F84_RS04840	COG4536	flavin adenine dinucleotide binding
B1F84_RS04845	COG4137	Cytochrome C assembly protein
B1F84_RS04850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1F84_RS04855	COG0228	four-way junction DNA binding
B1F84_RS04860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1F84_RS04865	COG0336	Belongs to the RNA methyltransferase TrmD family
B1F84_RS04870	COG0335	large ribosomal subunit rRNA binding
B1F84_RS04875	COG4286	Uncharacterised protein family (UPF0160)
B1F84_RS04880	COG0287	Prephenate dehydrogenase
B1F84_RS04880	COG1605	Chorismate mutase
B1F84_RS04885	COG1605	Chorismate mutase
B1F84_RS04885	COG0077	Prephenate dehydratase
B1F84_RS04895	COG0023	Translation Initiation Factor
B1F84_RS04905	COG1448	Aminotransferase
B1F84_RS04915	COG1595	DNA-templated transcription, initiation
B1F84_RS04925	COG2304	oxidoreductase activity
B1F84_RS04945	COG0714	Associated with various cellular activities
B1F84_RS04950	COG0183	Belongs to the thiolase family
B1F84_RS04960	COG2315	Protein conserved in bacteria
B1F84_RS04965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1F84_RS04975	COG1025	Belongs to the peptidase M16 family
B1F84_RS04980	COG2062	phosphohistidine phosphatase, SixA
B1F84_RS04990	COG2840	Smr protein MutS2
B1F84_RS04995	COG2890	protein-(glutamine-N5) methyltransferase activity
B1F84_RS05000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1F84_RS05035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B1F84_RS05040	COG3101	peptidyl-lysine hydroxylation
B1F84_RS05055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B1F84_RS05070	COG0071	Belongs to the small heat shock protein (HSP20) family
B1F84_RS05075	COG3046	protein related to deoxyribodipyrimidine photolyase
B1F84_RS05085	COG0779	Required for maturation of 30S ribosomal subunits
B1F84_RS05090	COG0195	Participates in both transcription termination and antitermination
B1F84_RS05095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1F84_RS05100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1F84_RS05105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1F84_RS05110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1F84_RS05115	COG1185	polyribonucleotide nucleotidyltransferase activity
B1F84_RS05130	COG2111	Na H antiporter
B1F84_RS05130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1F84_RS05135	COG1006	Multisubunit Na H antiporter MnhC subunit
B1F84_RS05140	COG0651	ATP synthesis coupled electron transport
B1F84_RS05145	COG1863	multisubunit Na H antiporter MnhE subunit
B1F84_RS05150	COG2212	antiporter activity
B1F84_RS05155	COG1320	monovalent cation:proton antiporter activity
B1F84_RS05165	COG0789	Transcriptional regulator
B1F84_RS05170	COG2217	Heavy metal translocating P-type atpase
B1F84_RS05210	COG1388	LysM domain
B1F84_RS05210	COG0741	lytic transglycosylase activity
B1F84_RS05215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1F84_RS05220	COG2226	methyltransferase
B1F84_RS05225	COG0328	RNA-DNA hybrid ribonuclease activity
B1F84_RS05300	COG0121	glutamine amidotransferase
B1F84_RS05310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B1F84_RS05315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1F84_RS05320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1F84_RS05325	COG2226	methyltransferase
B1F84_RS05335	COG1451	nucleotide metabolic process
B1F84_RS05340	COG1801	Protein of unknown function DUF72
B1F84_RS05345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1F84_RS05385	COG0513	Belongs to the DEAD box helicase family
B1F84_RS05405	COG2816	NAD+ diphosphatase activity
B1F84_RS05410	COG0626	cystathionine gamma-synthase activity
B1F84_RS05445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1F84_RS05450	COG1823	symporter activity
B1F84_RS05455	COG2197	response regulator
B1F84_RS05460	COG0322	excinuclease ABC activity
B1F84_RS05510	COG1115	amino acid carrier protein
B1F84_RS05540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1F84_RS05545	COG0072	phenylalanine-tRNA ligase activity
B1F84_RS05550	COG0776	regulation of translation
B1F84_RS05565	COG2866	Carboxypeptidase
B1F84_RS05570	COG1115	amino acid carrier protein
B1F84_RS05580	COG3139	Protein of unknown function (DUF1315)
B1F84_RS05600	COG3604	Transcriptional regulator
B1F84_RS05635	COG0427	acetyl-CoA hydrolase
B1F84_RS05655	COG2201	protein-glutamate methylesterase activity
B1F84_RS05660	COG4251	negative regulation of phosphorylation
B1F84_RS05670	COG2755	lipolytic protein G-D-S-L family
B1F84_RS05675	COG4181	ATPase activity
B1F84_RS05680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B1F84_RS05685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1F84_RS05690	COG0632	four-way junction helicase activity
B1F84_RS05695	COG2255	four-way junction helicase activity
B1F84_RS05700	COG0811	peptide transport
B1F84_RS05715	COG0823	Involved in the tonB-independent uptake of proteins
B1F84_RS05720	COG2885	chlorophyll binding
B1F84_RS05765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1F84_RS05780	COG3258	Cytochrome c
B1F84_RS05795	COG1902	pentaerythritol trinitrate reductase activity
B1F84_RS05815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B1F84_RS05820	COG1074	ATP-dependent DNA helicase activity
B1F84_RS05825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1F84_RS05830	COG2860	membrane
B1F84_RS05835	COG1473	amidohydrolase
B1F84_RS05850	COG0037	tRNA processing
B1F84_RS05855	COG0589	response to stress
B1F84_RS05860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1F84_RS05875	COG2217	Heavy metal translocating P-type atpase
B1F84_RS05885	COG2010	Cytochrome c
B1F84_RS05900	COG3278	Belongs to the heme-copper respiratory oxidase family
B1F84_RS05930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1F84_RS05935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F84_RS05940	COG2957	Belongs to the agmatine deiminase family
B1F84_RS05970	COG2188	Transcriptional regulator
B1F84_RS05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F84_RS06005	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B1F84_RS06015	COG3083	sulfuric ester hydrolase activity
B1F84_RS06020	COG3082	Protein of unknown function (DUF1414)
B1F84_RS06025	COG3081	Nucleoid-associated protein
B1F84_RS06030	COG1530	ribonuclease E activity
B1F84_RS06040	COG0546	phosphoglycolate phosphatase activity
B1F84_RS06045	COG0424	maF-like protein
B1F84_RS06050	COG1399	metal-binding, possibly nucleic acid-binding protein
B1F84_RS06055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1F84_RS06060	COG0416	fatty acid biosynthetic process
B1F84_RS06065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1F84_RS06075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1F84_RS06080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1F84_RS06085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1F84_RS06090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1F84_RS06095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1F84_RS06100	COG0470	DNA polymerase III
B1F84_RS06110	COG0084	hydrolase, TatD family'
B1F84_RS06130	COG2203	Gaf domain
B1F84_RS06130	COG2199	diguanylate cyclase activity
B1F84_RS06130	COG2200	EAL domain
B1F84_RS06140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1F84_RS06145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1F84_RS06150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B1F84_RS06170	COG0673	inositol 2-dehydrogenase activity
B1F84_RS06185	COG2226	methyltransferase
B1F84_RS06215	COG1596	polysaccharide export
B1F84_RS06235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B1F84_RS06235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1F84_RS06245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B1F84_RS06250	COG0372	Belongs to the citrate synthase family
B1F84_RS06255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1F84_RS06260	COG2828	Protein conserved in bacteria
B1F84_RS06265	COG3706	GGDEF domain
B1F84_RS06285	COG1943	Transposase
B1F84_RS06310	COG0307	riboflavin synthase, alpha
B1F84_RS06320	COG3001	Fructosamine kinase
B1F84_RS06340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1F84_RS06355	COG1278	Cold shock
B1F84_RS06360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1F84_RS06365	COG0542	response to heat
B1F84_RS06370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1F84_RS06375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B1F84_RS06380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B1F84_RS06385	COG1049	propionate catabolic process, 2-methylcitrate cycle
B1F84_RS06390	COG0492	ferredoxin-NADP+ reductase activity
B1F84_RS06395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1F84_RS06400	COG0686	Belongs to the AlaDH PNT family
B1F84_RS06410	COG1674	ftsk spoiiie
B1F84_RS06410	COG0531	amino acid
B1F84_RS06415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B1F84_RS06420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1F84_RS06425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1F84_RS06430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1F84_RS06440	COG3171	Protein conserved in bacteria
B1F84_RS06450	COG2133	pyrroloquinoline quinone binding
B1F84_RS06460	COG1914	H( )-stimulated, divalent metal cation uptake system
B1F84_RS06485	COG1132	(ABC) transporter
B1F84_RS06495	COG2234	aminopeptidase activity
B1F84_RS06530	COG1876	peptidase activity
B1F84_RS06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1F84_RS06540	COG1393	Belongs to the ArsC family
B1F84_RS06555	COG0280	phosphate acetyltransferase
B1F84_RS06555	COG0857	belongs to the CobB CobQ family
B1F84_RS06560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B1F84_RS06570	COG2226	methyltransferase
B1F84_RS06590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1F84_RS06595	COG1187	pseudouridine synthase activity
B1F84_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
B1F84_RS06605	COG2267	carboxylic ester hydrolase activity
B1F84_RS06610	COG3385	transposase activity
B1F84_RS06615	COG0616	signal peptide processing
B1F84_RS06620	COG1301	dicarboxylic acid transport
B1F84_RS06645	COG0366	Alpha amylase catalytic
B1F84_RS06720	COG0706	membrane insertase activity
B1F84_RS06735	COG2860	membrane
B1F84_RS06745	COG0837	glucose binding
B1F84_RS06750	COG1609	Transcriptional regulator
B1F84_RS06765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1F84_RS06790	COG0217	transcriptional regulatory protein
B1F84_RS06795	COG3590	peptidase
B1F84_RS06800	COG5265	(ABC) transporter
B1F84_RS06810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1F84_RS06815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1F84_RS06830	COG2824	Alkylphosphonate utilization operon protein PhnA
B1F84_RS06835	COG0189	ligase activity
B1F84_RS06840	COG1214	PFAM Peptidase M22, glycoprotease
B1F84_RS06840	COG0456	acetyltransferase
B1F84_RS06845	COG1285	pathogenesis
B1F84_RS06850	COG3300	MHYT domain
B1F84_RS06850	COG5001	Diguanylate cyclase
B1F84_RS06855	COG2199	diguanylate cyclase activity
B1F84_RS06890	COG0583	DNA-binding transcription factor activity
B1F84_RS06895	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1F84_RS06900	COG1136	(ABC) transporter
B1F84_RS06905	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1F84_RS06915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1F84_RS06920	COG5001	Diguanylate cyclase
B1F84_RS06920	COG4251	negative regulation of phosphorylation
B1F84_RS06920	COG3706	GGDEF domain
B1F84_RS06920	COG2203	Gaf domain
B1F84_RS06925	COG0318	PFAM AMP-dependent synthetase and ligase
B1F84_RS06940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1F84_RS06945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1F84_RS06950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1F84_RS06960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1F84_RS06965	COG1522	sequence-specific DNA binding
B1F84_RS06970	COG0659	secondary active sulfate transmembrane transporter activity
B1F84_RS06975	COG3275	phosphorelay sensor kinase activity
B1F84_RS06980	COG3279	Response regulator of the LytR AlgR family
B1F84_RS06985	COG0469	pyruvate kinase activity
B1F84_RS06995	COG0252	asparaginase activity
B1F84_RS07000	COG0616	signal peptide processing
B1F84_RS07005	COG1902	pentaerythritol trinitrate reductase activity
B1F84_RS07005	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1F84_RS07015	COG0778	Nitroreductase
B1F84_RS07035	COG0545	Peptidyl-prolyl cis-trans isomerase
B1F84_RS07065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1F84_RS07075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1F84_RS07085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1F84_RS07090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1F84_RS07095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1F84_RS07100	COG0539	negative regulation of cytoplasmic translation
B1F84_RS07105	COG0776	regulation of translation
B1F84_RS07115	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B1F84_RS07120	COG0284	orotidine-5'-phosphate decarboxylase activity
B1F84_RS07135	COG0513	Belongs to the DEAD box helicase family
B1F84_RS07140	COG1054	Belongs to the UPF0176 family
B1F84_RS07150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F84_RS07155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F84_RS07160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B1F84_RS07160	COG0517	IMP dehydrogenase activity
B1F84_RS07165	COG2176	DNA-directed DNA polymerase activity
B1F84_RS07170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1F84_RS07175	COG0367	asparagine synthase
B1F84_RS07180	COG1984	allophanate hydrolase subunit 2
B1F84_RS07185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B1F84_RS07195	COG0583	DNA-binding transcription factor activity
B1F84_RS07205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B1F84_RS07215	COG4770	biotin carboxylase activity
B1F84_RS07225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1F84_RS07230	COG1960	acyl-CoA dehydrogenase activity
B1F84_RS07240	COG0183	Belongs to the thiolase family
B1F84_RS07255	COG1024	Enoyl-CoA hydratase
B1F84_RS07260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B1F84_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
B1F84_RS07295	COG3038	cytochrome b561
B1F84_RS07305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1F84_RS07320	COG4628	conserved protein (DUF2132)
B1F84_RS07325	COG0604	alcohol dehydrogenase
B1F84_RS07330	COG1309	transcriptional regulator
B1F84_RS07335	COG3130	regulation of translation
B1F84_RS07340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1F84_RS07355	COG1607	acyl-coa hydrolase
B1F84_RS07360	COG2056	Na+-H+ antiporter family
B1F84_RS07375	COG0714	Associated with various cellular activities
B1F84_RS07380	COG2201	protein-glutamate methylesterase activity
B1F84_RS07390	COG0205	6-phosphofructokinase activity
B1F84_RS07425	COG0281	malic enzyme
B1F84_RS07430	COG0405	Gamma-glutamyltransferase
B1F84_RS07450	COG2855	membrane
B1F84_RS07460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1F84_RS07465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1F84_RS07475	COG0488	(ABC) transporter
B1F84_RS07490	COG1309	transcriptional regulator
B1F84_RS07525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1F84_RS07535	COG0583	DNA-binding transcription factor activity
B1F84_RS07545	COG0183	Belongs to the thiolase family
B1F84_RS07555	COG1278	Cold shock
B1F84_RS07580	COG0501	Belongs to the peptidase M48B family
B1F84_RS07585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B1F84_RS07590	COG2226	methyltransferase
B1F84_RS07600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1F84_RS07620	COG1178	ABC-type Fe3 transport system permease component
B1F84_RS07625	COG3842	ATPase activity
B1F84_RS07640	COG0017	Asparaginyl-tRNA synthetase
B1F84_RS07675	COG1720	tRNA m6t6A37 methyltransferase activity
B1F84_RS07680	COG0442	prolyl-tRNA aminoacylation
B1F84_RS07685	COG1668	transmembrane transport
B1F84_RS07690	COG4555	ABC transporter
B1F84_RS07715	COG0022	dehydrogenase e1 component
B1F84_RS07725	COG2988	succinylglutamate desuccinylase activity
B1F84_RS07730	COG0033	Phosphoglucomutase
B1F84_RS07735	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B1F84_RS07740	COG0596	Alpha beta hydrolase
B1F84_RS07760	COG0735	belongs to the Fur family
B1F84_RS07765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1F84_RS07780	COG0045	succinate-CoA ligase (ADP-forming) activity
B1F84_RS07785	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1F84_RS07790	COG0567	Dehydrogenase, E1 component
B1F84_RS07800	COG1053	succinate dehydrogenase
B1F84_RS07805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B1F84_RS07820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1F84_RS07825	COG2166	iron-sulfur cluster assembly
B1F84_RS07830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1F84_RS07835	COG0564	pseudouridine synthase activity
B1F84_RS07840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B1F84_RS07845	COG2835	tetraacyldisaccharide 4'-kinase activity
B1F84_RS07850	COG1663	tetraacyldisaccharide 4'-kinase activity
B1F84_RS07855	COG1132	(ABC) transporter
B1F84_RS07860	COG2333	competence protein COMEC
B1F84_RS07860	COG0658	competence protein
B1F84_RS07875	COG0488	(ABC) transporter
B1F84_RS07885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F84_RS07885	COG0116	Belongs to the methyltransferase superfamily
B1F84_RS07895	COG0167	dihydroorotate dehydrogenase activity
B1F84_RS07900	COG2902	Dehydrogenase
B1F84_RS07910	COG4447	cellulose binding
B1F84_RS07930	COG0308	aminopeptidase N
B1F84_RS07935	COG1757	Na H antiporter
B1F84_RS07945	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B1F84_RS07955	COG1956	GAF domain-containing protein
B1F84_RS07975	COG0670	Belongs to the BI1 family
B1F84_RS07985	COG2923	Belongs to the DsrF TusC family
B1F84_RS07995	COG2920	part of a sulfur-relay system
B1F84_RS08005	COG4251	negative regulation of phosphorylation
B1F84_RS08005	COG5001	Diguanylate cyclase
B1F84_RS08005	COG3706	GGDEF domain
B1F84_RS08005	COG2203	Gaf domain
B1F84_RS08010	COG0482	sulfurtransferase activity
B1F84_RS08015	COG2915	High frequency lysogenization protein hflD homolog
B1F84_RS08020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1F84_RS08025	COG2850	peptidyl-arginine hydroxylation
B1F84_RS08035	COG0436	Aminotransferase
B1F84_RS08055	COG0717	Belongs to the dCTP deaminase family
B1F84_RS08060	COG0489	protein tyrosine kinase activity
B1F84_RS08065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1F84_RS08065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1F84_RS08100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B1F84_RS08120	COG1063	alcohol dehydrogenase
B1F84_RS08130	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B1F84_RS08155	COG4771	TonB-dependent receptor
B1F84_RS08170	COG3038	cytochrome b561
B1F84_RS08180	COG0009	L-threonylcarbamoyladenylate synthase
B1F84_RS08185	COG0613	PHP domain protein
B1F84_RS08190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1F84_RS08195	COG0512	Glutamine amidotransferase of anthranilate synthase
B1F84_RS08200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1F84_RS08205	COG0135	phosphoribosylanthranilate isomerase activity
B1F84_RS08205	COG0134	indole-3-glycerol-phosphate synthase activity
B1F84_RS08220	COG0693	protein deglycase activity
B1F84_RS08225	COG0776	regulation of translation
B1F84_RS08235	COG0733	neurotransmitter:sodium symporter activity
B1F84_RS08240	COG2350	Protein conserved in bacteria
B1F84_RS08275	COG0492	ferredoxin-NADP+ reductase activity
B1F84_RS08280	COG0628	permease
B1F84_RS08285	COG1090	epimerase
B1F84_RS08305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1F84_RS08310	COG1505	serine-type exopeptidase activity
B1F84_RS08320	COG4771	TonB-dependent receptor
B1F84_RS08330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1F84_RS08340	COG0543	2 iron, 2 sulfur cluster binding
B1F84_RS08340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1F84_RS08345	COG2133	pyrroloquinoline quinone binding
B1F84_RS08375	COG0300	oxidoreductase activity
B1F84_RS08405	COG0477	Major facilitator Superfamily
B1F84_RS08410	COG0210	DNA helicase
B1F84_RS08415	COG1741	Belongs to the pirin family
B1F84_RS08420	COG0435	Glutathione S-transferase
B1F84_RS08425	COG2259	Doxx family
B1F84_RS08430	COG0583	DNA-binding transcription factor activity
B1F84_RS08450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F84_RS08455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1F84_RS08460	COG1012	belongs to the aldehyde dehydrogenase family
B1F84_RS08465	COG4638	Rieske (2fe-2S)
B1F84_RS08470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1F84_RS08475	COG0583	DNA-binding transcription factor activity
B1F84_RS08495	COG2925	Exonuclease
B1F84_RS08500	COG2084	Dehydrogenase
B1F84_RS08505	COG0386	Belongs to the glutathione peroxidase family
B1F84_RS08510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1F84_RS08520	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1F84_RS08525	COG0733	neurotransmitter:sodium symporter activity
B1F84_RS08535	COG0527	aspartate kinase activity
B1F84_RS08540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1F84_RS08580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F84_RS08595	COG0583	DNA-binding transcription factor activity
B1F84_RS08615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1F84_RS08620	COG0505	Belongs to the CarA family
B1F84_RS08625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1F84_RS08650	COG2814	Major facilitator Superfamily
B1F84_RS08655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1F84_RS08660	COG1420	regulation of RNA biosynthetic process
B1F84_RS08665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1F84_RS08675	COG0497	DNA recombination
B1F84_RS08685	COG0493	'glutamate synthase
B1F84_RS08690	COG0069	glutamate synthase activity
B1F84_RS08690	COG0070	glutamate synthase
B1F84_RS08690	COG0067	glutamate synthase
B1F84_RS08695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B1F84_RS08700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1F84_RS08705	COG2766	serine protein kinase
B1F84_RS08710	COG2718	Belongs to the UPF0229 family
B1F84_RS08715	COG2719	SpoVR family
B1F84_RS08725	COG3706	GGDEF domain
B1F84_RS08730	COG2201	protein-glutamate methylesterase activity
B1F84_RS08735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B1F84_RS08740	COG0563	adenylate kinase activity
B1F84_RS08745	COG0326	Molecular chaperone. Has ATPase activity
B1F84_RS08750	COG0564	pseudouridine synthase activity
B1F84_RS08755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1F84_RS08760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1F84_RS08765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1F84_RS08770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1F84_RS08775	COG3219	Protein conserved in bacteria
B1F84_RS08780	COG3220	belongs to the UPF0276 family
B1F84_RS08790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1F84_RS08815	COG0848	biopolymer transport protein
B1F84_RS08820	COG0811	peptide transport
B1F84_RS08825	COG0811	peptide transport
B1F84_RS08835	COG1278	Cold shock
B1F84_RS08840	COG0418	dihydroorotase activity
B1F84_RS08850	COG0583	DNA-binding transcription factor activity
B1F84_RS08855	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B1F84_RS08865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1F84_RS08885	COG1228	amidohydrolase
B1F84_RS08890	COG3228	Belongs to the MtfA family
B1F84_RS08895	COG3706	GGDEF domain
B1F84_RS08915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1F84_RS08925	COG1760	l-serine dehydratase
B1F84_RS08930	COG0583	DNA-binding transcription factor activity
B1F84_RS08940	COG2252	PERMEase
B1F84_RS08955	COG3012	SEC-C Motif Domain Protein
B1F84_RS08990	COG1418	mRNA catabolic process
B1F84_RS08995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F84_RS09010	COG1643	Atp-dependent helicase
B1F84_RS09045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B1F84_RS09050	COG0166	Belongs to the GPI family
B1F84_RS09075	COG4783	chaperone-mediated protein folding
B1F84_RS09080	COG1393	Belongs to the ArsC family
B1F84_RS09100	COG2854	intermembrane phospholipid transfer
B1F84_RS09105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B1F84_RS09115	COG3314	Sporulation integral membrane protein YlbJ
B1F84_RS09130	COG2716	regulation of RNA biosynthetic process
B1F84_RS09135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1F84_RS09165	COG0602	queuosine metabolic process
B1F84_RS09170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B1F84_RS09195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F84_RS09200	COG0556	nucleotide-excision repair
B1F84_RS09205	COG0534	Mate efflux family protein
B1F84_RS09230	COG2203	Gaf domain
B1F84_RS09230	COG2200	EAL domain
B1F84_RS09230	COG2199	diguanylate cyclase activity
B1F84_RS09235	COG4657	Part of a membrane complex involved in electron transport
B1F84_RS09240	COG2878	Part of a membrane complex involved in electron transport
B1F84_RS09250	COG4658	electron transport chain
B1F84_RS09255	COG4659	FMN binding
B1F84_RS09260	COG4660	Part of a membrane complex involved in electron transport
B1F84_RS09265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1F84_RS09280	COG1982	Orn Lys Arg decarboxylase major
B1F84_RS09290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B1F84_RS09380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1F84_RS09400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1F84_RS09405	COG3115	cell septum assembly
B1F84_RS09410	COG1196	nuclear chromosome segregation
B1F84_RS09415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1F84_RS09420	COG4269	membrane
B1F84_RS09440	COG1166	arginine decarboxylase activity
B1F84_RS09455	COG3385	transposase activity
B1F84_RS09460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1F84_RS09470	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B1F84_RS09475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B1F84_RS09480	COG2363	Small membrane protein
B1F84_RS09490	COG0583	DNA-binding transcription factor activity
B1F84_RS09510	COG3437	response regulator, receiver
B1F84_RS09510	COG0784	Response regulator, receiver
B1F84_RS09515	COG2890	protein-(glutamine-N5) methyltransferase activity
B1F84_RS09520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1F84_RS09525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1F84_RS09530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B1F84_RS09535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1F84_RS09545	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1F84_RS09550	COG0193	aminoacyl-tRNA hydrolase activity
B1F84_RS09555	COG0012	GTP binding
B1F84_RS09610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1F84_RS09615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1F84_RS09620	COG1702	phosphate starvation-inducible protein PhoH
B1F84_RS09625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1F84_RS09630	COG4535	Mg2 and Co2 transporter CorC
B1F84_RS09635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B1F84_RS09685	COG0545	Peptidyl-prolyl cis-trans isomerase
B1F84_RS09690	COG1067	ATP-dependent peptidase activity
B1F84_RS09695	COG2888	peptidyl-tyrosine sulfation
B1F84_RS09700	COG0495	leucyl-tRNA aminoacylation
B1F84_RS09705	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
B1F84_RS09715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1F84_RS09720	COG0799	negative regulation of ribosome biogenesis
B1F84_RS09725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B1F84_RS09730	COG0768	penicillin binding
B1F84_RS09735	COG0772	Belongs to the SEDS family
B1F84_RS09740	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B1F84_RS09745	COG1686	Belongs to the peptidase S11 family
B1F84_RS09750	COG2921	Belongs to the UPF0250 family
B1F84_RS09755	COG0321	lipoyl(octanoyl) transferase activity
B1F84_RS09760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1F84_RS09765	COG0724	RNA recognition motif
B1F84_RS09785	COG0564	pseudouridine synthase activity
B1F84_RS09790	COG3098	single-species biofilm formation
B1F84_RS09820	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
B1F84_RS09830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1F84_RS09830	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1F84_RS09845	COG0729	surface antigen
B1F84_RS09855	COG1061	Type III restriction enzyme res subunit
B1F84_RS09860	COG4771	TonB-dependent receptor
B1F84_RS09865	COG4206	TonB-dependent receptor
B1F84_RS09870	COG0417	DNA replication proofreading
B1F84_RS09875	COG1199	ATP-dependent helicase activity
B1F84_RS09890	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1F84_RS09915	COG0477	Major facilitator Superfamily
B1F84_RS09925	COG2391	methyltransferase activity
B1F84_RS09995	COG0037	tRNA processing
B1F84_RS10000	COG0825	malonyl-CoA metabolic process
B1F84_RS10005	COG0587	DNA-directed DNA polymerase activity
B1F84_RS10010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1F84_RS10015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F84_RS10025	COG1294	oxidase, subunit
B1F84_RS10030	COG4890	Cyd operon protein YbgT
B1F84_RS10035	COG4988	ABC transporter
B1F84_RS10040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B1F84_RS10045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B1F84_RS10050	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F84_RS10055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1F84_RS10060	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F84_RS10075	COG0750	zinc metalloprotease
B1F84_RS10080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1F84_RS10090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1F84_RS10100	COG0528	UMP kinase activity
B1F84_RS10105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1F84_RS10110	COG0052	Belongs to the universal ribosomal protein uS2 family
B1F84_RS10115	COG0024	Methionine aminopeptidase
B1F84_RS10120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B1F84_RS10125	COG2171	N-acyltransferase activity
B1F84_RS10135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1F84_RS10140	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1F84_RS10150	COG0626	cystathionine gamma-synthase activity
B1F84_RS10155	COG3768	UPF0283 membrane protein
B1F84_RS10160	COG3106	COG3106 Predicted ATPase
B1F84_RS10165	COG1983	PspC domain protein
B1F84_RS10175	COG1842	Phage shock protein A
B1F84_RS10180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B1F84_RS10185	COG0747	negative chemotaxis
B1F84_RS10205	COG4172	Belongs to the ABC transporter superfamily
B1F84_RS10210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F84_RS10220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1F84_RS10225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1F84_RS10230	COG0740	serine-type endopeptidase activity
B1F84_RS10235	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1F84_RS10265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1F84_RS10270	COG0697	spore germination
B1F84_RS10275	COG0215	cysteine-tRNA ligase activity
B1F84_RS10280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1F84_RS10290	COG4191	Histidine kinase
B1F84_RS10290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F84_RS10310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1F84_RS10315	COG1286	toxin biosynthetic process
B1F84_RS10325	COG0285	dihydrofolate synthase activity
B1F84_RS10330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1F84_RS10335	COG0101	tRNA pseudouridine synthase activity
B1F84_RS10350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F84_RS10355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1F84_RS10360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F84_RS10360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B1F84_RS10365	COG0702	epimerase
B1F84_RS10390	COG2885	chlorophyll binding
B1F84_RS10395	COG0814	amino acid
B1F84_RS10420	COG2197	response regulator
B1F84_RS10445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1F84_RS10450	COG0149	triose-phosphate isomerase activity
B1F84_RS10455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1F84_RS10460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1F84_RS10465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1F84_RS10470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B1F84_RS10475	COG1534	Rna-binding protein
B1F84_RS10505	COG0745	RESPONSE REGULATOR receiver
B1F84_RS10515	COG0733	neurotransmitter:sodium symporter activity
B1F84_RS10525	COG2153	protein acetylation
B1F84_RS10530	COG4326	sporulation control protein
B1F84_RS10545	COG2205	protein histidine kinase activity
B1F84_RS10550	COG0745	RESPONSE REGULATOR receiver
B1F84_RS10565	COG3706	GGDEF domain
B1F84_RS10570	COG0583	DNA-binding transcription factor activity
B1F84_RS10575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1F84_RS10600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1F84_RS10605	COG2914	Belongs to the UPF0125 (RnfH) family
B1F84_RS10610	COG2867	negative regulation of translational initiation
B1F84_RS10615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1F84_RS10620	COG4206	TonB-dependent receptor
B1F84_RS10625	COG0450	alkyl hydroperoxide reductase
B1F84_RS10640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1F84_RS10650	COG1555	photosystem II stabilization
B1F84_RS10655	COG3141	response to X-ray
B1F84_RS10660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1F84_RS10665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B1F84_RS10680	COG4235	cytochrome complex assembly
B1F84_RS10680	COG3088	subunit of a heme lyase
B1F84_RS10690	COG1138	Cytochrome C-type biogenesis protein
B1F84_RS10695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B1F84_RS10700	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1F84_RS10705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1F84_RS10710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1F84_RS10715	COG4133	protoheme IX ABC transporter activity
B1F84_RS10735	COG0835	chemotaxis
B1F84_RS10745	COG1192	Involved in chromosome partitioning
B1F84_RS10750	COG1360	Flagellar Motor Protein
B1F84_RS10755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1F84_RS10760	COG2201	protein-glutamate methylesterase activity
B1F84_RS10765	COG0643	Histidine kinase
B1F84_RS10765	COG0784	Response regulator, receiver
B1F84_RS10765	COG2198	Histidine kinase
B1F84_RS10770	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B1F84_RS10795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1F84_RS10810	COG1987	bacterial-type flagellum assembly
B1F84_RS10820	COG3190	flagellar
B1F84_RS10840	COG3144	bacterial-type flagellum assembly
B1F84_RS10860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1F84_RS10870	COG1677	Flagellar hook-basal body complex protein FliE
B1F84_RS10885	COG0519	Catalyzes the synthesis of GMP from XMP
B1F84_RS10895	COG1516	flagellar protein fliS
B1F84_RS10910	COG1334	flagellar protein FlaG
B1F84_RS10925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1F84_RS10935	COG3951	Flagellar rod assembly protein muramidase FlgJ
B1F84_RS10935	COG1705	Flagellar rod assembly protein muramidase FlgJ
B1F84_RS10940	COG1706	bacterial-type flagellum-dependent cell motility
B1F84_RS10945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B1F84_RS10950	COG4786	Flagellar basal body rod
B1F84_RS10955	COG4786	Flagellar basal body rod
B1F84_RS10975	COG1815	bacterial-type flagellum-dependent cell motility
B1F84_RS10980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1F84_RS10985	COG0835	chemotaxis
B1F84_RS10985	COG0784	Response regulator, receiver
B1F84_RS11020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1F84_RS11020	COG0678	peroxiredoxin activity
B1F84_RS11040	COG4974	Belongs to the 'phage' integrase family
B1F84_RS11045	COG0517	IMP dehydrogenase activity
B1F84_RS11075	COG1196	nuclear chromosome segregation
B1F84_RS11080	COG0732	type I restriction modification DNA specificity domain
B1F84_RS11105	COG3311	Transcriptional regulator
B1F84_RS11115	COG0582	viral genome integration into host DNA
B1F84_RS11175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1F84_RS11180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B1F84_RS11185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1F84_RS11190	COG0730	response to heat
B1F84_RS11200	COG1051	belongs to the nudix hydrolase family
B1F84_RS11205	COG3066	DNA modification
B1F84_RS11210	COG0148	phosphopyruvate hydratase activity
B1F84_RS11215	COG0504	CTP synthase activity
B1F84_RS11220	COG3956	TIGRFAM MazG family protein
B1F84_RS11225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1F84_RS11230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1F84_RS11235	COG4999	Histidine kinase
B1F84_RS11235	COG2205	protein histidine kinase activity
B1F84_RS11235	COG3437	response regulator, receiver
B1F84_RS11235	COG3850	Histidine kinase
B1F84_RS11240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B1F84_RS11245	COG1381	Involved in DNA repair and RecF pathway recombination
B1F84_RS11255	COG0571	ribonuclease III activity
B1F84_RS11265	COG0481	GTPase activity
B1F84_RS11275	COG3026	antisigma factor binding
B1F84_RS11285	COG1595	DNA-templated transcription, initiation
B1F84_RS11290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1F84_RS11300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B1F84_RS11305	COG0354	folic acid binding
B1F84_RS11310	COG1047	Peptidyl-prolyl cis-trans
B1F84_RS11330	COG1024	Enoyl-CoA hydratase
B1F84_RS11330	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1F84_RS11340	COG1346	cytolysis
B1F84_RS11345	COG0668	transmembrane transport
B1F84_RS11350	COG4249	Peptidase C14 caspase catalytic subunit p20
B1F84_RS11350	COG2319	Wd-40 repeat
B1F84_RS11360	COG5001	Diguanylate cyclase
B1F84_RS11360	COG4251	negative regulation of phosphorylation
B1F84_RS11360	COG3706	GGDEF domain
B1F84_RS11360	COG2203	Gaf domain
B1F84_RS11365	COG2239	Acts as a magnesium transporter
B1F84_RS11375	COG0788	formyltetrahydrofolate deformylase activity
B1F84_RS11380	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B1F84_RS11390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1F84_RS11400	COG4773	Receptor
B1F84_RS11415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1F84_RS11435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1F84_RS11440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1F84_RS11445	COG0585	pseudouridine synthase activity
B1F84_RS11450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1F84_RS11455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1F84_RS11460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B1F84_RS11505	COG3123	guanosine phosphorylase activity
B1F84_RS11535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1F84_RS11540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1F84_RS11550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1F84_RS11555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B1F84_RS11560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F84_RS11580	COG0560	Phosphoserine phosphatase
B1F84_RS11590	COG0084	hydrolase, TatD family'
B1F84_RS11595	COG0259	pyridoxamine-phosphate oxidase activity
B1F84_RS11600	COG0018	arginyl-trna synthetase
B1F84_RS11605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1F84_RS11670	COG1288	antiporter activity
B1F84_RS11695	COG1475	DNA binding
B1F84_RS11700	COG3969	phosphoadenosine phosphosulfate
B1F84_RS11720	COG3706	GGDEF domain
B1F84_RS11725	COG0459	protein refolding
B1F84_RS11730	COG0459	protein refolding
B1F84_RS11755	COG2003	Belongs to the UPF0758 family
B1F84_RS11780	COG0714	Associated with various cellular activities
B1F84_RS11795	COG0629	single-stranded DNA binding
B1F84_RS11830	COG0681	Belongs to the peptidase S26 family
B1F84_RS11890	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
B1F84_RS11965	COG0583	DNA-binding transcription factor activity
B1F84_RS11970	COG1012	belongs to the aldehyde dehydrogenase family
B1F84_RS11980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1F84_RS12075	COG1881	PFAM PEBP family protein
B1F84_RS12085	COG1733	regulation of RNA biosynthetic process
B1F84_RS12095	COG0778	Nitroreductase
B1F84_RS12135	COG3550	peptidyl-serine autophosphorylation
B1F84_RS12140	COG3620	sequence-specific DNA binding
B1F84_RS12145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1F84_RS12150	COG5002	protein histidine kinase activity
B1F84_RS12150	COG2198	Histidine kinase
B1F84_RS12150	COG0784	Response regulator, receiver
B1F84_RS12155	COG0456	acetyltransferase
B1F84_RS12170	COG0519	Catalyzes the synthesis of GMP from XMP
B1F84_RS12170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1F84_RS12175	COG0517	IMP dehydrogenase activity
B1F84_RS12175	COG0516	GMP reductase activity
B1F84_RS12180	COG1570	exodeoxyribonuclease VII activity
B1F84_RS12190	COG1045	serine acetyltransferase
B1F84_RS12205	COG0612	Peptidase, M16
B1F84_RS12225	COG0513	Belongs to the DEAD box helicase family
B1F84_RS12245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1F84_RS12255	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1F84_RS12260	COG0697	spore germination
B1F84_RS12285	COG0745	RESPONSE REGULATOR receiver
B1F84_RS12290	COG0642	Histidine kinase
B1F84_RS12305	COG0617	tRNA 3'-terminal CCA addition
B1F84_RS12315	COG0741	lytic transglycosylase activity
B1F84_RS12325	COG2204	response regulator
B1F84_RS12335	COG2205	protein histidine kinase activity
B1F84_RS12385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1F84_RS12390	COG1489	DNA binding
B1F84_RS12410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1F84_RS12420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1F84_RS12425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1F84_RS12430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1F84_RS12445	COG5002	protein histidine kinase activity
B1F84_RS12460	COG0126	phosphoglycerate kinase activity
B1F84_RS12465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1F84_RS12485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1F84_RS12495	COG5002	protein histidine kinase activity
B1F84_RS12495	COG2198	Histidine kinase
B1F84_RS12495	COG0784	Response regulator, receiver
B1F84_RS12505	COG3706	GGDEF domain
B1F84_RS12540	COG1979	alcohol dehydrogenase
B1F84_RS12545	COG2207	Transcriptional regulator
B1F84_RS12550	COG3706	GGDEF domain
B1F84_RS12570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B1F84_RS12595	COG2816	NAD+ diphosphatase activity
B1F84_RS12605	COG0668	transmembrane transport
B1F84_RS12615	COG1902	pentaerythritol trinitrate reductase activity
B1F84_RS12630	COG1823	symporter activity
B1F84_RS12635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1F84_RS12640	COG0477	Major facilitator Superfamily
B1F84_RS12650	COG0517	IMP dehydrogenase activity
B1F84_RS12650	COG1125	glycine betaine transport
B1F84_RS12660	COG0783	Belongs to the Dps family
B1F84_RS12690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B1F84_RS12710	COG1757	Na H antiporter
B1F84_RS12715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1F84_RS12720	COG3876	Protein conserved in bacteria
B1F84_RS12750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1F84_RS12760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1F84_RS12765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1F84_RS12775	COG0716	FMN binding
B1F84_RS12785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B1F84_RS12790	COG0513	Belongs to the DEAD box helicase family
B1F84_RS12800	COG0668	transmembrane transport
B1F84_RS12810	COG3022	response to hydroperoxide
B1F84_RS12815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1F84_RS12825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1F84_RS12830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1F84_RS12835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B1F84_RS12840	COG1492	cobalamin metabolic process
B1F84_RS12845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F84_RS12850	COG1120	ATPase activity
B1F84_RS12860	COG0583	DNA-binding transcription factor activity
B1F84_RS12865	COG3085	chromosome segregation
B1F84_RS12875	COG2962	Rard protein
B1F84_RS12880	COG2050	protein possibly involved in aromatic compounds catabolism
B1F84_RS12885	COG0514	ATP-dependent DNA helicase (RecQ)
B1F84_RS12910	COG0189	ligase activity
B1F84_RS12915	COG0189	ligase activity
B1F84_RS12915	COG4067	protein conserved in archaea
B1F84_RS12925	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B1F84_RS12930	COG0204	Acyl-transferase
B1F84_RS12950	COG3150	esterase
B1F84_RS12960	COG3151	Protein conserved in bacteria
B1F84_RS12965	COG0494	nUDIX hydrolase
B1F84_RS12970	COG1538	Outer membrane efflux protein
B1F84_RS12975	COG1560	Kdo2-lipid A biosynthetic process
B1F84_RS12985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B1F84_RS13000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1F84_RS13005	COG0189	ligase activity
B1F84_RS13010	COG1678	Uncharacterized ACR, COG1678
B1F84_RS13015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1F84_RS13030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B1F84_RS13035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1F84_RS13040	COG0762	integral membrane protein
B1F84_RS13050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1F84_RS13055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1F84_RS13075	COG0045	succinate-CoA ligase (ADP-forming) activity
B1F84_RS13075	COG1042	CoA-binding domain protein
B1F84_RS13075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1F84_RS13080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1F84_RS13105	COG3313	Fe-S protein
B1F84_RS13115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1F84_RS13135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1F84_RS13140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1F84_RS13155	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1F84_RS13170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B1F84_RS13175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F84_RS13180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B1F84_RS13185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1F84_RS13190	COG2967	ApaG domain
B1F84_RS13200	COG0840	transmembrane signaling receptor activity
B1F84_RS13210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1F84_RS13215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1F84_RS13220	COG2003	Belongs to the UPF0758 family
B1F84_RS13225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1F84_RS13235	COG4946	Tricorn protease homolog
B1F84_RS13235	COG1506	peptidase
B1F84_RS13235	COG0823	Involved in the tonB-independent uptake of proteins
B1F84_RS13240	COG3706	GGDEF domain
B1F84_RS13250	COG2081	HI0933 family
B1F84_RS13255	COG1404	Belongs to the peptidase S8 family
B1F84_RS13260	COG0678	peroxiredoxin activity
B1F84_RS13260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1F84_RS13280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1F84_RS13285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1F84_RS13290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1F84_RS13295	COG0142	geranyltranstransferase activity
B1F84_RS13300	COG0039	L-malate dehydrogenase activity
B1F84_RS13305	COG1438	arginine binding
B1F84_RS13315	COG3842	ATPase activity
B1F84_RS13325	COG1840	ABC-type Fe3 transport system, periplasmic component
B1F84_RS13330	COG3148	PFAM DTW domain containing protein
B1F84_RS13340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1F84_RS13345	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1F84_RS13350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1F84_RS13355	COG2186	Transcriptional regulator
B1F84_RS13395	COG0237	dephospho-CoA kinase activity
B1F84_RS13400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1F84_RS13405	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B1F84_RS13415	COG0745	RESPONSE REGULATOR receiver
B1F84_RS13420	COG2205	protein histidine kinase activity
B1F84_RS13425	COG2267	carboxylic ester hydrolase activity
B1F84_RS13435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B1F84_RS13440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1F84_RS13445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B1F84_RS13450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1F84_RS13455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1F84_RS13465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1F84_RS13470	COG4942	peptidase
B1F84_RS13475	COG0793	Belongs to the peptidase S41A family
B1F84_RS13495	COG2177	Part of the ABC transporter FtsEX involved in
B1F84_RS13500	COG2884	Cell division ATP-binding protein ftsE
B1F84_RS13505	COG0552	protein localization to endoplasmic reticulum
B1F84_RS13510	COG0742	ribosomal rna small subunit methyltransferase
B1F84_RS13515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B1F84_RS13535	COG2264	protein methyltransferase activity
B1F84_RS13540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1F84_RS13545	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B1F84_RS13550	COG0138	bifunctional purine biosynthesis protein purh
B1F84_RS13560	COG0151	Belongs to the GarS family
B1F84_RS13565	COG3300	MHYT domain
B1F84_RS13565	COG5001	Diguanylate cyclase
B1F84_RS13585	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1F84_RS13600	COG1280	lysine exporter protein (LysE YggA)
B1F84_RS13620	COG0823	Involved in the tonB-independent uptake of proteins
B1F84_RS13645	COG2823	Periplasmic or secreted lipoprotein
B1F84_RS13670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1F84_RS13675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1F84_RS13680	COG1862	Preprotein translocase
B1F84_RS13685	COG0343	queuine tRNA-ribosyltransferase activity
B1F84_RS13690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1F84_RS13695	COG5002	protein histidine kinase activity
B1F84_RS13695	COG5001	Diguanylate cyclase
B1F84_RS13705	COG0583	DNA-binding transcription factor activity
B1F84_RS13710	COG0306	phosphate transporter
B1F84_RS13715	COG1392	Phosphate transport regulator
B1F84_RS13720	COG0704	Plays a role in the regulation of phosphate uptake
B1F84_RS13725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1F84_RS13730	COG0573	inorganic phosphate transmembrane transporter activity
B1F84_RS13735	COG0573	inorganic phosphate transmembrane transporter activity
B1F84_RS13750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F84_RS13775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B1F84_RS13780	COG2824	Alkylphosphonate utilization operon protein PhnA
B1F84_RS13790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B1F84_RS13800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B1F84_RS13810	COG0741	lytic transglycosylase activity
B1F84_RS13810	COG1388	LysM domain
B1F84_RS13825	COG3618	amidohydrolase
B1F84_RS13840	COG4948	Mandelate Racemase Muconate Lactonizing
B1F84_RS13865	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
B1F84_RS13880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1F84_RS13885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1F84_RS13895	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B1F84_RS13900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1F84_RS13905	COG0330	HflC and HflK could
B1F84_RS13910	COG0330	HflC and HflK could
B1F84_RS13915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1F84_RS13920	COG1923	regulation of RNA biosynthetic process
B1F84_RS13925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1F84_RS13930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1F84_RS13935	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1F84_RS13940	COG0802	atpase or kinase
B1F84_RS13945	COG0439	Biotin carboxylase
B1F84_RS13950	COG0511	ligase activity, forming carbon-carbon bonds
B1F84_RS13955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1F84_RS13960	COG4232	protein-disulfide reductase activity
B1F84_RS13965	COG1324	tolerance protein
B1F84_RS13975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1F84_RS13980	COG0459	protein refolding
B1F84_RS13985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1F84_RS13990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B1F84_RS13990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1F84_RS14010	COG0203	ribosomal protein L17
B1F84_RS14015	COG0202	RNA polymerase activity
B1F84_RS14020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1F84_RS14025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1F84_RS14030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1F84_RS14035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1F84_RS14040	COG0201	protein transport
B1F84_RS14045	COG0200	Binds to the 23S rRNA
B1F84_RS14050	COG1841	ribosomal large subunit assembly
B1F84_RS14055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1F84_RS14060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1F84_RS14065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1F84_RS14070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1F84_RS14075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1F84_RS14080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1F84_RS14085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1F84_RS14090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1F84_RS14130	COG4555	ABC transporter
B1F84_RS14150	COG0640	Transcriptional regulator
B1F84_RS14190	COG1132	(ABC) transporter
B1F84_RS14200	COG2885	chlorophyll binding
B1F84_RS14210	COG0668	transmembrane transport
B1F84_RS14215	COG0204	Acyl-transferase
B1F84_RS14220	COG0204	Acyl-transferase
B1F84_RS14225	COG1166	arginine decarboxylase activity
B1F84_RS14230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1F84_RS14245	COG1082	Xylose isomerase domain protein TIM barrel
B1F84_RS14260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1F84_RS14275	COG2183	response to ionizing radiation
B1F84_RS14290	COG0596	Alpha beta hydrolase
B1F84_RS14295	COG1040	competence protein
B1F84_RS14305	COG0316	Belongs to the HesB IscA family
B1F84_RS14305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B1F84_RS14315	COG0534	Mate efflux family protein
B1F84_RS14325	COG2201	protein-glutamate methylesterase activity
B1F84_RS14330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B1F84_RS14335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1F84_RS14345	COG0835	chemotaxis
B1F84_RS14350	COG2198	Histidine kinase
B1F84_RS14350	COG0643	Histidine kinase
B1F84_RS14355	COG0745	RESPONSE REGULATOR receiver
B1F84_RS14370	COG0109	protoheme IX farnesyltransferase activity
B1F84_RS14405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1F84_RS14440	COG1017	nitric oxide dioxygenase activity
B1F84_RS14440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1F84_RS14455	COG3604	Transcriptional regulator
B1F84_RS14465	COG0431	NADPH-dependent FMN reductase
B1F84_RS14490	COG0066	3-isopropylmalate dehydratase activity
B1F84_RS14495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1F84_RS14500	COG0473	3-isopropylmalate dehydrogenase activity
B1F84_RS14505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1F84_RS14520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1F84_RS14525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1F84_RS14530	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
B1F84_RS14535	COG0545	Peptidyl-prolyl cis-trans isomerase
B1F84_RS14545	COG2900	Belongs to the SlyX family
B1F84_RS14550	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B1F84_RS14555	COG0488	(ABC) transporter
B1F84_RS14565	COG0429	hydrolase of the alpha beta-hydrolase fold
B1F84_RS14570	COG3089	Belongs to the UPF0270 family
B1F84_RS14580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1F84_RS14605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1F84_RS14615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1F84_RS14630	COG0537	adenosine 5'-monophosphoramidase activity
B1F84_RS14655	COG0436	Aminotransferase
B1F84_RS14660	COG0235	Class ii aldolase
B1F84_RS14665	COG0069	glutamate synthase activity
B1F84_RS14680	COG2226	methyltransferase
B1F84_RS14695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1F84_RS14700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1F84_RS14705	COG0805	protein transport
B1F84_RS14720	COG3706	GGDEF domain
B1F84_RS14720	COG5001	Diguanylate cyclase
B1F84_RS14720	COG2203	Gaf domain
B1F84_RS14720	COG4251	negative regulation of phosphorylation
B1F84_RS14735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1F84_RS14740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B1F84_RS14745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B1F84_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
B1F84_RS14755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1F84_RS14760	COG2610	gluconate transmembrane transporter activity
B1F84_RS14775	COG0784	Response regulator, receiver
B1F84_RS14775	COG2205	protein histidine kinase activity
B1F84_RS14790	COG4681	YaeQ
B1F84_RS14805	COG0783	Belongs to the Dps family
B1F84_RS14810	COG1770	oligopeptidase
B1F84_RS14815	COG3397	chitin binding
B1F84_RS14855	COG3428	Bacterial PH domain
B1F84_RS14865	COG0676	glucose-6-phosphate 1-epimerase activity
B1F84_RS14900	COG4771	TonB-dependent receptor
B1F84_RS14920	COG1136	(ABC) transporter
B1F84_RS14935	COG1785	Belongs to the alkaline phosphatase family
B1F84_RS14945	COG2807	transmembrane transport
B1F84_RS14950	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B1F84_RS14960	COG0583	DNA-binding transcription factor activity
B1F84_RS14975	COG0513	Belongs to the DEAD box helicase family
B1F84_RS14995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1F84_RS15000	COG1349	DNA-binding transcription factor activity
B1F84_RS15005	COG0110	maltose O-acetyltransferase activity
B1F84_RS15030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1F84_RS15035	COG3710	Transcriptional regulator
B1F84_RS15040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1F84_RS15045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1F84_RS15050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1F84_RS15055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1F84_RS15060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1F84_RS15065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1F84_RS15075	COG0356	it plays a direct role in the translocation of protons across the membrane
B1F84_RS15085	COG1475	DNA binding
B1F84_RS15090	COG1192	Involved in chromosome partitioning
B1F84_RS15095	COG0357	Ribosomal RNA small subunit methyltransferase G
B1F84_RS15100	COG0445	tRNA wobble uridine modification
B1F84_RS15105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B1F84_RS15110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1F84_RS15115	COG0706	membrane insertase activity
B1F84_RS15120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1F84_RS15125	COG0594	ribonuclease P activity
B1F84_RS15130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1F84_RS15140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1F84_RS15160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1F84_RS15165	COG0813	purine-nucleoside phosphorylase activity
B1F84_RS15170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B1F84_RS15175	COG0572	uridine kinase
B1F84_RS15180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B1F84_RS15190	COG1278	Cold shock
B1F84_RS15215	COG0745	RESPONSE REGULATOR receiver
B1F84_RS15255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1F84_RS15270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B1F84_RS15275	COG0217	transcriptional regulatory protein
B1F84_RS15300	COG0420	3'-5' exonuclease activity
B1F84_RS15315	COG1278	Cold shock
B1F84_RS15335	COG1671	Belongs to the UPF0178 family
B1F84_RS15340	COG3040	lipid binding
B1F84_RS15390	COG1566	PFAM secretion protein HlyD family protein
B1F84_RS15395	COG1846	Transcriptional regulator
B1F84_RS15420	COG0583	DNA-binding transcription factor activity
B1F84_RS15435	COG4264	IucA IucC family
B1F84_RS15445	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1F84_RS15450	COG0076	glutamate decarboxylase activity
B1F84_RS15500	COG0730	response to heat
B1F84_RS15545	COG1322	Protein conserved in bacteria
B1F84_RS15550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1F84_RS15575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1F84_RS15580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B1F84_RS15585	COG0574	Belongs to the PEP-utilizing enzyme family
B1F84_RS15585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1F84_RS15595	COG0247	lactate metabolic process
B1F84_RS15595	COG0277	FAD linked oxidase domain protein
B1F84_RS15600	COG3263	regulation of cellular component size
B1F84_RS15625	COG1115	amino acid carrier protein
B1F84_RS15630	COG4667	esterase of the alpha-beta hydrolase superfamily
B1F84_RS15635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1F84_RS15645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1F84_RS15650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F84_RS15665	COG3227	Zinc metalloprotease (Elastase)
B1F84_RS15675	COG4895	conserved protein (DUF2196)
B1F84_RS15695	COG0840	transmembrane signaling receptor activity
B1F84_RS15720	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B1F84_RS15725	COG0848	biopolymer transport protein
B1F84_RS15730	COG0811	peptide transport
B1F84_RS15735	COG0811	peptide transport
B1F84_RS15770	COG2983	Belongs to the UPF0260 family
B1F84_RS15800	COG2951	lytic endotransglycosylase activity
B1F84_RS15805	COG3100	YcgL domain-containing protein
B1F84_RS15810	COG0850	regulation of cytokinetic process
B1F84_RS15815	COG2894	cell division
B1F84_RS15820	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B1F84_RS15830	COG0318	PFAM AMP-dependent synthetase and ligase
B1F84_RS15845	COG1785	Belongs to the alkaline phosphatase family
B1F84_RS15860	COG1199	ATP-dependent helicase activity
B1F84_RS15870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1F84_RS15875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1F84_RS15880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1F84_RS15885	COG0131	Imidazoleglycerol-phosphate dehydratase
B1F84_RS15885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1F84_RS15890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1F84_RS15895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1F84_RS15905	COG0753	catalase activity
B1F84_RS15915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F84_RS15920	COG0107	imidazoleglycerol-phosphate synthase activity
B1F84_RS15925	COG0140	phosphoribosyl-ATP diphosphatase activity
B1F84_RS15925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1F84_RS15945	COG2873	o-acetylhomoserine
B1F84_RS15985	COG1611	Belongs to the LOG family
B1F84_RS15990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1F84_RS16005	COG0473	3-isopropylmalate dehydrogenase activity
B1F84_RS16010	COG0028	Belongs to the TPP enzyme family
B1F84_RS16015	COG0440	acetolactate synthase activity
B1F84_RS16040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1F84_RS16065	COG0415	Belongs to the DNA photolyase family
B1F84_RS16080	COG1595	DNA-templated transcription, initiation
B1F84_RS16095	COG1272	protein, Hemolysin III
B1F84_RS16110	COG0583	DNA-binding transcription factor activity
B1F84_RS16115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F84_RS16120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F84_RS16125	COG1187	pseudouridine synthase activity
B1F84_RS16130	COG2311	Membrane
B1F84_RS16135	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B1F84_RS16150	COG0058	SHG alpha-glucan phosphorylase activity
B1F84_RS16160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1F84_RS16165	COG1640	4-alpha-glucanotransferase
B1F84_RS16190	COG1522	sequence-specific DNA binding
B1F84_RS16195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1F84_RS16200	COG3138	arginine N-succinyltransferase
B1F84_RS16205	COG1012	belongs to the aldehyde dehydrogenase family
B1F84_RS16230	COG1309	transcriptional regulator
B1F84_RS16235	COG1012	belongs to the aldehyde dehydrogenase family
B1F84_RS16240	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B1F84_RS16260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B1F84_RS16265	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B1F84_RS16270	COG0154	amidase activity
B1F84_RS16275	COG0513	Belongs to the DEAD box helicase family
B1F84_RS16290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1F84_RS16325	COG3706	GGDEF domain
B1F84_RS16330	COG0596	Alpha beta hydrolase
B1F84_RS16345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1F84_RS16360	COG1879	ABC-type sugar transport system periplasmic component
B1F84_RS16365	COG0366	Alpha amylase catalytic
B1F84_RS16370	COG1215	transferase activity, transferring glycosyl groups
B1F84_RS16375	COG3769	mannosylglycerate metabolic process
B1F84_RS16385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1F84_RS16420	COG1063	alcohol dehydrogenase
B1F84_RS16435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F84_RS16465	COG0471	metal ion transport
B1F84_RS16475	COG2204	response regulator
B1F84_RS16480	COG4191	Histidine kinase
B1F84_RS16505	COG0484	heat shock protein binding
B1F84_RS16510	COG0443	Heat shock 70 kDa protein
B1F84_RS16525	COG2995	paraquat-inducible protein a
B1F84_RS16530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1F84_RS16530	COG3008	intermembrane lipid transfer
B1F84_RS16545	COG1757	Na H antiporter
B1F84_RS16550	COG1025	Belongs to the peptidase M16 family
B1F84_RS16560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1F84_RS16570	COG0737	Belongs to the 5'-nucleotidase family
B1F84_RS16600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B1F84_RS16605	COG0625	glutathione transferase activity
B1F84_RS16620	COG4628	conserved protein (DUF2132)
B1F84_RS16625	COG1803	Methylglyoxal synthase
B1F84_RS16625	COG1597	lipid kinase activity
B1F84_RS16630	COG1595	DNA-templated transcription, initiation
B1F84_RS16665	COG1538	Outer membrane efflux protein
B1F84_RS16680	COG1253	flavin adenine dinucleotide binding
B1F84_RS16690	COG0010	Belongs to the arginase family
B1F84_RS16695	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B1F84_RS16700	COG0295	cytidine deaminase activity
B1F84_RS16705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1F84_RS16740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F84_RS16750	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B1F84_RS16760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1F84_RS16770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1F84_RS16790	COG0457	Tetratricopeptide repeat
B1F84_RS16800	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B1F84_RS16805	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B1F84_RS16810	COG1435	thymidine kinase activity
B1F84_RS16830	COG1230	cation diffusion facilitator family transporter
B1F84_RS16840	COG2193	ferroxidase activity
B1F84_RS16850	COG2906	2 iron, 2 sulfur cluster binding
B1F84_RS16855	COG0537	adenosine 5'-monophosphoramidase activity
B1F84_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
B1F84_RS16875	COG0346	lactoylglutathione lyase activity
B1F84_RS16900	COG2119	membrane
B1F84_RS16910	COG0840	transmembrane signaling receptor activity
B1F84_RS16930	COG2203	Gaf domain
B1F84_RS16930	COG3706	GGDEF domain
B1F84_RS16930	COG5001	Diguanylate cyclase
B1F84_RS16930	COG4251	negative regulation of phosphorylation
B1F84_RS16950	COG4977	sequence-specific DNA binding
B1F84_RS16955	COG4667	esterase of the alpha-beta hydrolase superfamily
B1F84_RS16960	COG0784	Response regulator, receiver
B1F84_RS16960	COG2205	protein histidine kinase activity
B1F84_RS16970	COG3634	alkyl hydroperoxide reductase activity
B1F84_RS16985	COG5002	protein histidine kinase activity
B1F84_RS16985	COG0784	Response regulator, receiver
B1F84_RS16985	COG2205	protein histidine kinase activity
B1F84_RS16990	COG0784	Response regulator, receiver
B1F84_RS16990	COG2205	protein histidine kinase activity
B1F84_RS17025	COG0673	inositol 2-dehydrogenase activity
B1F84_RS17035	COG4771	TonB-dependent receptor
B1F84_RS17040	COG0457	Tetratricopeptide repeat
B1F84_RS17070	COG1280	lysine exporter protein (LysE YggA)
B1F84_RS17090	COG0823	Involved in the tonB-independent uptake of proteins
B1F84_RS17090	COG1506	peptidase
B1F84_RS17090	COG4946	Tricorn protease homolog
B1F84_RS17095	COG0564	pseudouridine synthase activity
B1F84_RS17130	COG4136	ATPase activity
B1F84_RS17135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1F84_RS17185	COG1609	Transcriptional regulator
B1F84_RS17220	COG0625	glutathione transferase activity
B1F84_RS17230	COG1966	Carbon starvation protein
B1F84_RS17235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1F84_RS17300	COG0789	Transcriptional regulator
B1F84_RS17435	COG1360	Flagellar Motor Protein
B1F84_RS17480	COG1309	transcriptional regulator
B1F84_RS17485	COG0840	transmembrane signaling receptor activity
B1F84_RS17495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1F84_RS17500	COG0640	Transcriptional regulator
B1F84_RS17505	COG1764	response to oxidative stress
B1F84_RS17510	COG1846	Transcriptional regulator
B1F84_RS17515	COG3724	N-succinylarginine dihydrolase activity
B1F84_RS17525	COG4221	oxidoreductase activity
B1F84_RS17530	COG3300	MHYT domain
B1F84_RS17530	COG5001	Diguanylate cyclase
B1F84_RS17535	COG0745	RESPONSE REGULATOR receiver
B1F84_RS17545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1F84_RS17550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1F84_RS17555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1F84_RS17560	COG0826	peptidase U32
B1F84_RS17570	COG0105	UTP biosynthetic process
B1F84_RS17575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1F84_RS17590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1F84_RS17595	COG0124	histidyl-tRNA synthetase
B1F84_RS17600	COG2976	Protein conserved in bacteria
B1F84_RS17605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1F84_RS17610	COG1160	GTP binding
B1F84_RS17620	COG0415	Belongs to the DNA photolyase family
B1F84_RS17635	COG0583	DNA-binding transcription factor activity
B1F84_RS17640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1F84_RS17645	COG3002	Belongs to the UPF0753 family
B1F84_RS17655	COG0009	L-threonylcarbamoyladenylate synthase
B1F84_RS17660	COG1716	ATPase activity
B1F84_RS17660	COG5001	Diguanylate cyclase
B1F84_RS17670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1F84_RS17680	COG2130	NADP-dependent
B1F84_RS17695	COG0514	ATP-dependent DNA helicase (RecQ)
B1F84_RS17700	COG1252	NADH dehydrogenase
B1F84_RS17715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B1F84_RS17720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1F84_RS17725	COG2971	BadF BadG BcrA BcrD
B1F84_RS17735	COG1609	Transcriptional regulator
B1F84_RS17745	COG3036	rescue of stalled ribosome
B1F84_RS17755	COG0745	RESPONSE REGULATOR receiver
B1F84_RS17775	COG4191	Histidine kinase
B1F84_RS17785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1F84_RS17790	COG3135	benzoate transporter
B1F84_RS17855	COG1061	Type III restriction enzyme res subunit
B1F84_RS17895	COG1653	transport
B1F84_RS17910	COG0488	(ABC) transporter