locus-tag	class	description
PSPO_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PSPO_RS00020	COG0187	DNA topoisomerase II activity
PSPO_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
PSPO_RS00030	COG0751	glycine-tRNA ligase activity
PSPO_RS00040	COG0425	Belongs to the sulfur carrier protein TusA family
PSPO_RS00045	COG0183	Belongs to the thiolase family
PSPO_RS00050	COG1250	3-hydroxyacyl-CoA dehydrogenase
PSPO_RS00050	COG1024	Enoyl-CoA hydratase
PSPO_RS00055	COG0741	lytic transglycosylase activity
PSPO_RS00060	COG0006	proline dipeptidase activity
PSPO_RS00065	COG1739	Uncharacterized protein family UPF0029
PSPO_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PSPO_RS00080	COG0569	domain protein
PSPO_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PSPO_RS00085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PSPO_RS00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PSPO_RS00095	COG0242	peptide deformylase activity
PSPO_RS00105	COG0758	DNA mediated transformation
PSPO_RS00110	COG2922	Belongs to the Smg family
PSPO_RS00115	COG0551	DNA topoisomerase type I activity
PSPO_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
PSPO_RS00125	COG0408	coproporphyrinogen oxidase activity
PSPO_RS00130	COG0840	transmembrane signaling receptor activity
PSPO_RS00135	COG2346	COG2346, Truncated hemoglobins
PSPO_RS00140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PSPO_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PSPO_RS00185	COG1444	tRNA N-acetyltransferase activity
PSPO_RS00205	COG1011	Hydrolase
PSPO_RS00210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PSPO_RS00220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PSPO_RS00225	COG0019	diaminopimelate decarboxylase activity
PSPO_RS00235	COG1965	Belongs to the frataxin family
PSPO_RS00240	COG0400	carboxylic ester hydrolase activity
PSPO_RS00250	COG0181	hydroxymethylbilane synthase activity
PSPO_RS00265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PSPO_RS00295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PSPO_RS00320	COG3118	belongs to the thioredoxin family
PSPO_RS00330	COG0248	Ppx GppA phosphatase
PSPO_RS00385	COG0330	HflC and HflK could
PSPO_RS00390	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
PSPO_RS00420	COG4555	ABC transporter
PSPO_RS00450	COG4989	oxidoreductase activity
PSPO_RS00470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PSPO_RS00480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PSPO_RS00485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PSPO_RS00490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PSPO_RS00495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PSPO_RS00500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PSPO_RS00505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PSPO_RS00510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PSPO_RS00515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PSPO_RS00520	COG1841	ribosomal large subunit assembly
PSPO_RS00525	COG0200	Binds to the 23S rRNA
PSPO_RS00530	COG0201	protein transport
PSPO_RS00535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PSPO_RS00540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PSPO_RS00545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PSPO_RS00555	COG0202	RNA polymerase activity
PSPO_RS00560	COG0203	ribosomal protein L17
PSPO_RS00575	COG0537	adenosine 5'-monophosphoramidase activity
PSPO_RS00590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PSPO_RS00600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PSPO_RS00625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PSPO_RS00630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PSPO_RS00640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PSPO_RS00645	COG0250	Participates in transcription elongation, termination and antitermination
PSPO_RS00650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PSPO_RS00660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PSPO_RS00665	COG0222	ribosome binding
PSPO_RS00670	COG0085	RNA polymerase activity
PSPO_RS00675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PSPO_RS00680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PSPO_RS00685	COG0049	tRNA binding
PSPO_RS00690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PSPO_RS00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PSPO_RS00735	COG0531	amino acid
PSPO_RS00740	COG1522	sequence-specific DNA binding
PSPO_RS00745	COG1770	oligopeptidase
PSPO_RS00755	COG0583	DNA-binding transcription factor activity
PSPO_RS00760	COG0454	-acetyltransferase
PSPO_RS00805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PSPO_RS00850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PSPO_RS00865	COG4221	oxidoreductase activity
PSPO_RS00875	COG0415	Belongs to the DNA photolyase family
PSPO_RS00885	COG3806	Anti-sigma factor
PSPO_RS00890	COG1595	DNA-templated transcription, initiation
PSPO_RS00955	COG1704	LemA family
PSPO_RS00980	COG1011	Hydrolase
PSPO_RS00985	COG0494	nUDIX hydrolase
PSPO_RS00990	COG1218	3'(2'),5'-bisphosphate nucleotidase
PSPO_RS01010	COG0484	heat shock protein binding
PSPO_RS01020	COG3089	Belongs to the UPF0270 family
PSPO_RS01025	COG0429	hydrolase of the alpha beta-hydrolase fold
PSPO_RS01040	COG0488	(ABC) transporter
PSPO_RS01045	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PSPO_RS01060	COG0545	Peptidyl-prolyl cis-trans isomerase
PSPO_RS01075	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
PSPO_RS01080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PSPO_RS01085	COG1515	deoxyribonuclease V activity
PSPO_RS01095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PSPO_RS01105	COG1309	transcriptional regulator
PSPO_RS01110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PSPO_RS01165	COG4206	TonB-dependent receptor
PSPO_RS01175	COG0051	transcription antitermination factor activity, RNA binding
PSPO_RS01180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PSPO_RS01185	COG0088	Forms part of the polypeptide exit tunnel
PSPO_RS01190	COG0089	rRNA binding
PSPO_RS01195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PSPO_RS01200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PSPO_RS01205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PSPO_RS01210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PSPO_RS01215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PSPO_RS01220	COG0255	Belongs to the universal ribosomal protein uL29 family
PSPO_RS01225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PSPO_RS01240	COG1595	DNA-templated transcription, initiation
PSPO_RS01250	COG2205	protein histidine kinase activity
PSPO_RS01255	COG0745	RESPONSE REGULATOR receiver
PSPO_RS01260	COG0569	domain protein
PSPO_RS01265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PSPO_RS01270	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PSPO_RS01275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PSPO_RS01280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PSPO_RS01285	COG3031	protein transport across the cell outer membrane
PSPO_RS01295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSPO_RS01300	COG1459	type II secretion system
PSPO_RS01305	COG2165	general secretion pathway protein
PSPO_RS01315	COG2165	general secretion pathway protein
PSPO_RS01320	COG4795	General secretion pathway protein
PSPO_RS01325	COG3156	type II secretion system protein K
PSPO_RS01330	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PSPO_RS01335	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PSPO_RS01360	COG0348	domain, Protein
PSPO_RS01370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PSPO_RS01385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PSPO_RS01390	COG0473	3-isopropylmalate dehydrogenase activity
PSPO_RS01395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PSPO_RS01400	COG0066	3-isopropylmalate dehydratase activity
PSPO_RS01415	COG0606	chelatase, subunit chli
PSPO_RS01420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PSPO_RS01435	COG1253	flavin adenine dinucleotide binding
PSPO_RS01450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PSPO_RS01475	COG0419	ATPase involved in DNA repair
PSPO_RS01480	COG0420	3'-5' exonuclease activity
PSPO_RS01495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PSPO_RS01525	COG3267	Type II secretory pathway component ExeA
PSPO_RS01525	COG3409	Peptidoglycan-binding domain 1 protein
PSPO_RS01535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSPO_RS01550	COG2165	general secretion pathway protein
PSPO_RS01555	COG2165	general secretion pathway protein
PSPO_RS01585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PSPO_RS01590	COG1077	Cell shape determining protein MreB Mrl
PSPO_RS01595	COG1792	Involved in formation and maintenance of cell shape
PSPO_RS01600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PSPO_RS01605	COG0424	maF-like protein
PSPO_RS01610	COG1530	ribonuclease E activity
PSPO_RS01615	COG3164	Protein of unknown function
PSPO_RS01620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PSPO_RS01625	COG0312	modulator of DNA gyrase
PSPO_RS01640	COG0312	modulator of DNA gyrase
PSPO_RS01660	COG2001	Belongs to the MraZ family
PSPO_RS01665	COG0275	rRNA processing
PSPO_RS01670	COG3116	cell division
PSPO_RS01675	COG0768	penicillin binding
PSPO_RS01685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PSPO_RS01690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PSPO_RS01695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PSPO_RS01700	COG0772	Belongs to the SEDS family
PSPO_RS01705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PSPO_RS01710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PSPO_RS01715	COG1181	Belongs to the D-alanine--D-alanine ligase family
PSPO_RS01720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PSPO_RS01725	COG0849	cell division
PSPO_RS01730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PSPO_RS01735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PSPO_RS01745	COG2832	Protein of unknown function (DUF454)
PSPO_RS01750	COG0668	transmembrane transport
PSPO_RS01780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSPO_RS01785	COG1459	type II secretion system
PSPO_RS01825	COG1450	Type ii and iii secretion system protein
PSPO_RS01870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PSPO_RS01875	COG0673	inositol 2-dehydrogenase activity
PSPO_RS01890	COG0463	Glycosyl transferase, family 2
PSPO_RS01915	COG2755	lipolytic protein G-D-S-L family
PSPO_RS01915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PSPO_RS01930	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PSPO_RS02020	COG0463	Glycosyl transferase, family 2
PSPO_RS02035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PSPO_RS02040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PSPO_RS02080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PSPO_RS02095	COG2022	thiamine diphosphate biosynthetic process
PSPO_RS02100	COG0352	thiamine-phosphate diphosphorylase activity
PSPO_RS02115	COG0688	phosphatidylethanolamine metabolic process
PSPO_RS02120	COG1162	GTPase activity
PSPO_RS02125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PSPO_RS02150	COG3954	Phosphoribulokinase
PSPO_RS02165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PSPO_RS02180	COG0625	glutathione transferase activity
PSPO_RS02185	COG1247	-acetyltransferase
PSPO_RS02190	COG3291	Pkd domain containing protein
PSPO_RS02225	COG2205	protein histidine kinase activity
PSPO_RS02225	COG2202	Pas domain
PSPO_RS02235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PSPO_RS02240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PSPO_RS02240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PSPO_RS02245	COG0802	atpase or kinase
PSPO_RS02255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PSPO_RS02260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PSPO_RS02265	COG1923	regulation of RNA biosynthetic process
PSPO_RS02270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PSPO_RS02275	COG0330	HflC and HflK could
PSPO_RS02280	COG0330	HflC and HflK could
PSPO_RS02290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PSPO_RS02295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PSPO_RS02300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PSPO_RS02305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSPO_RS02310	COG1522	sequence-specific DNA binding
PSPO_RS02325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PSPO_RS02330	COG1758	RNA polymerase activity
PSPO_RS02335	COG0194	GDP metabolic process
PSPO_RS02340	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
PSPO_RS02345	COG1011	Hydrolase
PSPO_RS02350	COG0840	transmembrane signaling receptor activity
PSPO_RS02355	COG1187	pseudouridine synthase activity
PSPO_RS02360	COG4206	TonB-dependent receptor
PSPO_RS02380	COG1280	lysine exporter protein (LysE YggA)
PSPO_RS02395	COG0123	including yeast histone deacetylase and acetoin utilization protein
PSPO_RS02410	COG5001	Diguanylate cyclase
PSPO_RS02415	COG0151	Belongs to the GarS family
PSPO_RS02425	COG0138	bifunctional purine biosynthesis protein purh
PSPO_RS02430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PSPO_RS02435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PSPO_RS02440	COG2264	protein methyltransferase activity
PSPO_RS02460	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PSPO_RS02465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PSPO_RS02470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PSPO_RS02480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PSPO_RS02485	COG1968	undecaprenyl-diphosphatase activity
PSPO_RS02490	COG2205	protein histidine kinase activity
PSPO_RS02495	COG0617	tRNA 3'-terminal CCA addition
PSPO_RS02500	COG3267	Type II secretory pathway component ExeA
PSPO_RS02500	COG3409	Peptidoglycan-binding domain 1 protein
PSPO_RS02520	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PSPO_RS02520	COG0506	proline dehydrogenase activity
PSPO_RS02520	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PSPO_RS02530	COG4991	sh3 domain protein
PSPO_RS02535	COG3025	triphosphatase activity
PSPO_RS02555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PSPO_RS02560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PSPO_RS02580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PSPO_RS02585	COG0126	phosphoglycerate kinase activity
PSPO_RS02600	COG0745	RESPONSE REGULATOR receiver
PSPO_RS02605	COG5002	protein histidine kinase activity
PSPO_RS02620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PSPO_RS02625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PSPO_RS02630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PSPO_RS02640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PSPO_RS02650	COG1489	DNA binding
PSPO_RS02655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PSPO_RS02675	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PSPO_RS02685	COG2205	protein histidine kinase activity
PSPO_RS02690	COG0745	RESPONSE REGULATOR receiver
PSPO_RS02695	COG2885	chlorophyll binding
PSPO_RS02725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PSPO_RS02730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PSPO_RS02775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PSPO_RS02780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PSPO_RS02815	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
PSPO_RS02825	COG2315	Protein conserved in bacteria
PSPO_RS02835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PSPO_RS02850	COG4191	Histidine kinase
PSPO_RS02855	COG0745	RESPONSE REGULATOR receiver
PSPO_RS02860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PSPO_RS02865	COG0463	Glycosyl transferase, family 2
PSPO_RS02880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PSPO_RS02885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PSPO_RS02890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PSPO_RS02895	COG0585	pseudouridine synthase activity
PSPO_RS02900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PSPO_RS02905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PSPO_RS02910	COG1388	LysM domain
PSPO_RS02910	COG4942	peptidase
PSPO_RS02920	COG0142	geranyltranstransferase activity
PSPO_RS02925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PSPO_RS02930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PSPO_RS02935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PSPO_RS02950	COG0840	transmembrane signaling receptor activity
PSPO_RS02955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PSPO_RS02965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PSPO_RS02970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PSPO_RS02975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSPO_RS02980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PSPO_RS02985	COG3178	'Phosphotransferase
PSPO_RS02990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PSPO_RS02995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PSPO_RS03005	COG0564	pseudouridine synthase activity
PSPO_RS03010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PSPO_RS03015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PSPO_RS03030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PSPO_RS03035	COG0789	Transcriptional regulator
PSPO_RS03040	COG0701	Predicted permease
PSPO_RS03075	COG3313	Fe-S protein
PSPO_RS03100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PSPO_RS03105	COG1042	CoA-binding domain protein
PSPO_RS03105	COG0045	succinate-CoA ligase (ADP-forming) activity
PSPO_RS03105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PSPO_RS03125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PSPO_RS03150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PSPO_RS03160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PSPO_RS03165	COG0826	peptidase U32
PSPO_RS03170	COG0105	UTP biosynthetic process
PSPO_RS03175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PSPO_RS03190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PSPO_RS03195	COG0124	histidyl-tRNA synthetase
PSPO_RS03200	COG2976	Protein conserved in bacteria
PSPO_RS03205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PSPO_RS03210	COG1160	GTP binding
PSPO_RS03240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PSPO_RS03245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PSPO_RS03255	COG0137	argininosuccinate synthase activity
PSPO_RS03260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PSPO_RS03260	COG0165	Argininosuccinate lyase
PSPO_RS03280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PSPO_RS03295	COG1519	Transferase
PSPO_RS03310	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PSPO_RS03315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PSPO_RS03315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PSPO_RS03320	COG3642	lipopolysaccharide core region biosynthetic process
PSPO_RS03325	COG0859	PFAM glycosyl transferase family 9
PSPO_RS03330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PSPO_RS03340	COG1063	alcohol dehydrogenase
PSPO_RS03345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PSPO_RS03355	COG1580	Controls the rotational direction of flagella during chemotaxis
PSPO_RS03360	COG3161	chorismate lyase activity
PSPO_RS03365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PSPO_RS03375	COG0583	DNA-binding transcription factor activity
PSPO_RS03380	COG0784	Response regulator, receiver
PSPO_RS03380	COG3437	response regulator, receiver
PSPO_RS03395	COG3068	Protein conserved in bacteria
PSPO_RS03400	COG0742	ribosomal rna small subunit methyltransferase
PSPO_RS03405	COG0552	protein localization to endoplasmic reticulum
PSPO_RS03410	COG2884	Cell division ATP-binding protein ftsE
PSPO_RS03415	COG2177	Part of the ABC transporter FtsEX involved in
PSPO_RS03515	COG2974	May be involved in recombination
PSPO_RS03520	COG4191	Histidine kinase
PSPO_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PSPO_RS03540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PSPO_RS03545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PSPO_RS03565	COG3022	response to hydroperoxide
PSPO_RS03580	COG3408	Glycogen debranching enzyme
PSPO_RS03580	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
PSPO_RS03585	COG2169	Transcriptional regulator
PSPO_RS03585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PSPO_RS03590	COG0513	Belongs to the DEAD box helicase family
PSPO_RS03595	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PSPO_RS03600	COG0716	FMN binding
PSPO_RS03605	COG4974	Belongs to the 'phage' integrase family
PSPO_RS03610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PSPO_RS03625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PSPO_RS03645	COG1309	transcriptional regulator
PSPO_RS03650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PSPO_RS03655	COG1346	cytolysis
PSPO_RS03660	COG1380	Effector of murein hydrolase LrgA
PSPO_RS03665	COG1024	Enoyl-CoA hydratase
PSPO_RS03670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS03680	COG3099	Belongs to the UPF0263 family
PSPO_RS03705	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PSPO_RS03715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PSPO_RS03720	COG1595	DNA-templated transcription, initiation
PSPO_RS03725	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
PSPO_RS03740	COG0481	GTPase activity
PSPO_RS03750	COG0571	ribonuclease III activity
PSPO_RS03755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PSPO_RS03760	COG1381	Involved in DNA repair and RecF pathway recombination
PSPO_RS03765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PSPO_RS03775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PSPO_RS03780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PSPO_RS03785	COG3956	TIGRFAM MazG family protein
PSPO_RS03790	COG0504	CTP synthase activity
PSPO_RS03795	COG0148	phosphopyruvate hydratase activity
PSPO_RS03800	COG3066	DNA modification
PSPO_RS03805	COG1051	belongs to the nudix hydrolase family
PSPO_RS03810	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PSPO_RS03815	COG0730	response to heat
PSPO_RS03820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PSPO_RS03825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PSPO_RS03830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PSPO_RS03880	COG0784	Response regulator, receiver
PSPO_RS03880	COG0835	chemotaxis
PSPO_RS03885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PSPO_RS03890	COG1815	bacterial-type flagellum-dependent cell motility
PSPO_RS03910	COG4787	bacterial-type flagellum-dependent cell motility
PSPO_RS03915	COG4786	Flagellar basal body rod
PSPO_RS03920	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PSPO_RS03925	COG1706	bacterial-type flagellum-dependent cell motility
PSPO_RS03930	COG3951	Flagellar rod assembly protein muramidase FlgJ
PSPO_RS03930	COG1705	Flagellar rod assembly protein muramidase FlgJ
PSPO_RS04025	COG2089	acid synthase
PSPO_RS04035	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
PSPO_RS04045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PSPO_RS04050	COG1086	Polysaccharide biosynthesis protein
PSPO_RS04055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PSPO_RS04100	COG1051	belongs to the nudix hydrolase family
PSPO_RS04105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PSPO_RS04115	COG1595	DNA-templated transcription, initiation
PSPO_RS04125	COG2304	oxidoreductase activity
PSPO_RS04145	COG0714	Associated with various cellular activities
PSPO_RS04155	COG0183	Belongs to the thiolase family
PSPO_RS04160	COG1024	Enoyl-CoA hydratase
PSPO_RS04160	COG1250	3-hydroxyacyl-CoA dehydrogenase
PSPO_RS04175	COG1025	Belongs to the peptidase M16 family
PSPO_RS04185	COG2840	Smr protein MutS2
PSPO_RS04190	COG2890	protein-(glutamine-N5) methyltransferase activity
PSPO_RS04195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PSPO_RS04200	COG3101	peptidyl-lysine hydroxylation
PSPO_RS04220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSPO_RS04235	COG1984	allophanate hydrolase subunit 2
PSPO_RS04245	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PSPO_RS04250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSPO_RS04265	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PSPO_RS04270	COG2186	Transcriptional regulator
PSPO_RS04275	COG0450	alkyl hydroperoxide reductase
PSPO_RS04280	COG3047	cAMP biosynthetic process
PSPO_RS04305	COG2201	protein-glutamate methylesterase activity
PSPO_RS04310	COG0268	Binds directly to 16S ribosomal RNA
PSPO_RS04315	COG0728	peptidoglycan biosynthetic process
PSPO_RS04320	COG0196	riboflavin kinase activity
PSPO_RS04325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PSPO_RS04330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PSPO_RS04335	COG1047	Peptidyl-prolyl cis-trans
PSPO_RS04340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PSPO_RS04345	COG3275	phosphorelay sensor kinase activity
PSPO_RS04395	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PSPO_RS04400	COG0564	pseudouridine synthase activity
PSPO_RS04405	COG1496	oxidoreductase activity
PSPO_RS04410	COG0542	response to heat
PSPO_RS04420	COG2918	glutathione biosynthetic process
PSPO_RS04430	COG4536	flavin adenine dinucleotide binding
PSPO_RS04435	COG4137	Cytochrome C assembly protein
PSPO_RS04440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PSPO_RS04445	COG0228	four-way junction DNA binding
PSPO_RS04450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PSPO_RS04455	COG0336	Belongs to the RNA methyltransferase TrmD family
PSPO_RS04460	COG0335	large ribosomal subunit rRNA binding
PSPO_RS04465	COG0287	Prephenate dehydrogenase
PSPO_RS04465	COG1605	Chorismate mutase
PSPO_RS04470	COG0077	Prephenate dehydratase
PSPO_RS04470	COG1605	Chorismate mutase
PSPO_RS04480	COG0023	Translation Initiation Factor
PSPO_RS04490	COG0745	RESPONSE REGULATOR receiver
PSPO_RS04500	COG1448	Aminotransferase
PSPO_RS04505	COG3141	response to X-ray
PSPO_RS04520	COG0784	Response regulator, receiver
PSPO_RS04520	COG4191	Histidine kinase
PSPO_RS04635	COG2353	YceI-like domain
PSPO_RS04640	COG3038	cytochrome b561
PSPO_RS04645	COG0519	Catalyzes the synthesis of GMP from XMP
PSPO_RS04670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PSPO_RS04695	COG1580	Controls the rotational direction of flagella during chemotaxis
PSPO_RS04735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PSPO_RS04760	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PSPO_RS04765	COG2198	Histidine kinase
PSPO_RS04765	COG0784	Response regulator, receiver
PSPO_RS04765	COG0643	Histidine kinase
PSPO_RS04770	COG2201	protein-glutamate methylesterase activity
PSPO_RS04775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PSPO_RS04780	COG1360	Flagellar Motor Protein
PSPO_RS04785	COG1192	Involved in chromosome partitioning
PSPO_RS04795	COG0835	chemotaxis
PSPO_RS04815	COG4133	protoheme IX ABC transporter activity
PSPO_RS04820	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PSPO_RS04825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PSPO_RS04830	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PSPO_RS04835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PSPO_RS04840	COG1138	Cytochrome C-type biogenesis protein
PSPO_RS04855	COG3088	subunit of a heme lyase
PSPO_RS04855	COG4235	cytochrome complex assembly
PSPO_RS04860	COG2853	Lipoprotein
PSPO_RS04865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PSPO_RS04870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PSPO_RS04875	COG0668	transmembrane transport
PSPO_RS04880	COG4771	TonB-dependent receptor
PSPO_RS04905	COG1793	dna ligase
PSPO_RS04910	COG1803	Methylglyoxal synthase
PSPO_RS04925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PSPO_RS04935	COG0739	heme binding
PSPO_RS04940	COG0179	Fumarylacetoacetate (FAA) hydrolase
PSPO_RS04950	COG0737	Belongs to the 5'-nucleotidase family
PSPO_RS04955	COG3104	oligopeptide transport
PSPO_RS04965	COG5265	(ABC) transporter
PSPO_RS04970	COG3118	belongs to the thioredoxin family
PSPO_RS04970	COG0457	Tetratricopeptide repeat
PSPO_RS04975	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PSPO_RS04980	COG1215	transferase activity, transferring glycosyl groups
PSPO_RS04985	COG1215	transferase activity, transferring glycosyl groups
PSPO_RS05000	COG2194	sulfuric ester hydrolase activity
PSPO_RS05025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PSPO_RS05030	COG2867	negative regulation of translational initiation
PSPO_RS05035	COG2914	Belongs to the UPF0125 (RnfH) family
PSPO_RS05040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PSPO_RS05045	COG2827	Endonuclease containing a URI domain
PSPO_RS05060	COG2837	iron assimilation
PSPO_RS05065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PSPO_RS05070	COG0583	DNA-binding transcription factor activity
PSPO_RS05085	COG0745	RESPONSE REGULATOR receiver
PSPO_RS05115	COG2195	Cleaves the N-terminal amino acid of tripeptides
PSPO_RS05130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PSPO_RS05130	COG4651	solute:proton antiporter activity
PSPO_RS05135	COG4326	sporulation control protein
PSPO_RS05140	COG2153	protein acetylation
PSPO_RS05145	COG0733	neurotransmitter:sodium symporter activity
PSPO_RS05150	COG2205	protein histidine kinase activity
PSPO_RS05155	COG0745	RESPONSE REGULATOR receiver
PSPO_RS05175	COG1534	Rna-binding protein
PSPO_RS05180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PSPO_RS05185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PSPO_RS05190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PSPO_RS05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PSPO_RS05200	COG0149	triose-phosphate isomerase activity
PSPO_RS05205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PSPO_RS05225	COG2204	response regulator
PSPO_RS05230	COG1288	antiporter activity
PSPO_RS05235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PSPO_RS05240	COG0602	queuosine metabolic process
PSPO_RS05245	COG0741	lytic transglycosylase activity
PSPO_RS05245	COG1388	LysM domain
PSPO_RS05250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PSPO_RS05255	COG2226	methyltransferase
PSPO_RS05315	COG2165	general secretion pathway protein
PSPO_RS05320	COG0488	(ABC) transporter
PSPO_RS05335	COG1960	acyl-CoA dehydrogenase activity
PSPO_RS05350	COG0121	glutamine amidotransferase
PSPO_RS05360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PSPO_RS05365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PSPO_RS05370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PSPO_RS05375	COG2226	methyltransferase
PSPO_RS05395	COG1451	nucleotide metabolic process
PSPO_RS05400	COG1801	Protein of unknown function DUF72
PSPO_RS05405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PSPO_RS05410	COG0840	transmembrane signaling receptor activity
PSPO_RS05415	COG2311	Membrane
PSPO_RS05420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PSPO_RS05425	COG0632	four-way junction helicase activity
PSPO_RS05430	COG2255	four-way junction helicase activity
PSPO_RS05435	COG0811	peptide transport
PSPO_RS05450	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS05455	COG2885	chlorophyll binding
PSPO_RS05460	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PSPO_RS05490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PSPO_RS05505	COG5290	Psort location Cytoplasmic, score
PSPO_RS05510	COG1404	Belongs to the peptidase S8 family
PSPO_RS05520	COG3618	amidohydrolase
PSPO_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS05535	COG0741	lytic transglycosylase activity
PSPO_RS05535	COG1388	LysM domain
PSPO_RS05555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PSPO_RS05580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PSPO_RS05585	COG0321	lipoyl(octanoyl) transferase activity
PSPO_RS05590	COG2921	Belongs to the UPF0250 family
PSPO_RS05595	COG1686	Belongs to the peptidase S11 family
PSPO_RS05600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PSPO_RS05605	COG0772	Belongs to the SEDS family
PSPO_RS05610	COG0768	penicillin binding
PSPO_RS05615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PSPO_RS05620	COG0799	negative regulation of ribosome biogenesis
PSPO_RS05625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PSPO_RS05630	COG1466	dna polymerase III delta subunit
PSPO_RS05640	COG0495	leucyl-tRNA aminoacylation
PSPO_RS05650	COG1067	ATP-dependent peptidase activity
PSPO_RS05655	COG5002	protein histidine kinase activity
PSPO_RS05655	COG2205	protein histidine kinase activity
PSPO_RS05655	COG0784	Response regulator, receiver
PSPO_RS05660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PSPO_RS05665	COG4535	Mg2 and Co2 transporter CorC
PSPO_RS05670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PSPO_RS05675	COG1702	phosphate starvation-inducible protein PhoH
PSPO_RS05680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PSPO_RS05685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PSPO_RS05735	COG0012	GTP binding
PSPO_RS05740	COG0193	aminoacyl-tRNA hydrolase activity
PSPO_RS05745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PSPO_RS05750	COG1061	Type III restriction enzyme res subunit
PSPO_RS05755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PSPO_RS05760	COG2719	SpoVR family
PSPO_RS05765	COG2718	Belongs to the UPF0229 family
PSPO_RS05770	COG2766	serine protein kinase
PSPO_RS05775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PSPO_RS05780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PSPO_RS05795	COG0070	glutamate synthase
PSPO_RS05795	COG0069	glutamate synthase activity
PSPO_RS05795	COG0067	glutamate synthase
PSPO_RS05800	COG0493	'glutamate synthase
PSPO_RS05805	COG0497	DNA recombination
PSPO_RS05815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PSPO_RS05820	COG1420	regulation of RNA biosynthetic process
PSPO_RS05825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PSPO_RS05830	COG2814	Major facilitator Superfamily
PSPO_RS05835	COG4783	chaperone-mediated protein folding
PSPO_RS05860	COG0583	DNA-binding transcription factor activity
PSPO_RS05865	COG1760	l-serine dehydratase
PSPO_RS05870	COG0494	nUDIX hydrolase
PSPO_RS05895	COG1643	Atp-dependent helicase
PSPO_RS05905	COG3228	Belongs to the MtfA family
PSPO_RS05910	COG0583	DNA-binding transcription factor activity
PSPO_RS05915	COG2259	Doxx family
PSPO_RS05920	COG1741	Belongs to the pirin family
PSPO_RS05925	COG0435	Glutathione S-transferase
PSPO_RS05935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PSPO_RS05960	COG2350	Protein conserved in bacteria
PSPO_RS05965	COG0733	neurotransmitter:sodium symporter activity
PSPO_RS05990	COG2917	probably involved in intracellular septation
PSPO_RS06005	COG0135	phosphoribosylanthranilate isomerase activity
PSPO_RS06005	COG0134	indole-3-glycerol-phosphate synthase activity
PSPO_RS06010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PSPO_RS06015	COG0512	Glutamine amidotransferase of anthranilate synthase
PSPO_RS06020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PSPO_RS06035	COG0009	L-threonylcarbamoyladenylate synthase
PSPO_RS06045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PSPO_RS06050	COG1187	pseudouridine synthase activity
PSPO_RS06055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PSPO_RS06060	COG2716	regulation of RNA biosynthetic process
PSPO_RS06070	COG3314	Sporulation integral membrane protein YlbJ
PSPO_RS06085	COG1104	cysteine desulfurase activity
PSPO_RS06095	COG0166	Belongs to the GPI family
PSPO_RS06100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PSPO_RS06105	COG0363	glucosamine-6-phosphate deaminase activity
PSPO_RS06120	COG4232	protein-disulfide reductase activity
PSPO_RS06160	COG1446	asparaginase
PSPO_RS06165	COG1643	Atp-dependent helicase
PSPO_RS06175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PSPO_RS06190	COG4771	TonB-dependent receptor
PSPO_RS06195	COG2205	protein histidine kinase activity
PSPO_RS06195	COG0784	Response regulator, receiver
PSPO_RS06200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PSPO_RS06200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PSPO_RS06210	COG0717	Belongs to the dCTP deaminase family
PSPO_RS06215	COG3148	PFAM DTW domain containing protein
PSPO_RS06225	COG0436	Aminotransferase
PSPO_RS06230	COG1876	peptidase activity
PSPO_RS06235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PSPO_RS06240	COG1393	Belongs to the ArsC family
PSPO_RS06255	COG0280	phosphate acetyltransferase
PSPO_RS06255	COG0857	belongs to the CobB CobQ family
PSPO_RS06260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PSPO_RS06265	COG3092	negative regulation of chromosome organization
PSPO_RS06270	COG2226	methyltransferase
PSPO_RS06280	COG0708	Exodeoxyribonuclease III
PSPO_RS06285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PSPO_RS06290	COG1074	ATP-dependent DNA helicase activity
PSPO_RS06295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PSPO_RS06345	COG2252	PERMEase
PSPO_RS06360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PSPO_RS06365	COG0366	Alpha amylase catalytic
PSPO_RS06380	COG1523	belongs to the glycosyl hydrolase 13 family
PSPO_RS06400	COG1609	Transcriptional regulator
PSPO_RS06405	COG0837	glucose binding
PSPO_RS06410	COG1609	Transcriptional regulator
PSPO_RS06425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PSPO_RS06445	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PSPO_RS06470	COG0534	Mate efflux family protein
PSPO_RS06475	COG0307	riboflavin synthase, alpha
PSPO_RS06485	COG3001	Fructosamine kinase
PSPO_RS06500	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PSPO_RS06505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PSPO_RS06525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PSPO_RS06550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PSPO_RS06555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PSPO_RS06560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PSPO_RS06570	COG0300	oxidoreductase activity
PSPO_RS06580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PSPO_RS06585	COG1522	sequence-specific DNA binding
PSPO_RS06590	COG0659	secondary active sulfate transmembrane transporter activity
PSPO_RS06595	COG2972	Histidine kinase
PSPO_RS06600	COG3279	Response regulator of the LytR AlgR family
PSPO_RS06605	COG0604	alcohol dehydrogenase
PSPO_RS06620	COG0037	tRNA processing
PSPO_RS06625	COG0589	response to stress
PSPO_RS06630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PSPO_RS06645	COG2217	Heavy metal translocating P-type atpase
PSPO_RS06655	COG2010	Cytochrome c
PSPO_RS06670	COG3278	Belongs to the heme-copper respiratory oxidase family
PSPO_RS06690	COG0538	isocitrate dehydrogenase activity
PSPO_RS06715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PSPO_RS06735	COG0659	secondary active sulfate transmembrane transporter activity
PSPO_RS06740	COG4591	ABC-type transport system involved in lipoprotein release permease component
PSPO_RS06745	COG1136	(ABC) transporter
PSPO_RS06750	COG4591	ABC-type transport system involved in lipoprotein release permease component
PSPO_RS06755	COG0786	glutamate:sodium symporter activity
PSPO_RS06775	COG2850	peptidyl-arginine hydroxylation
PSPO_RS06780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PSPO_RS06785	COG2915	High frequency lysogenization protein hflD homolog
PSPO_RS06790	COG0482	sulfurtransferase activity
PSPO_RS06795	COG1187	pseudouridine synthase activity
PSPO_RS06805	COG1278	Cold shock
PSPO_RS06810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PSPO_RS06815	COG0542	response to heat
PSPO_RS06820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PSPO_RS06825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PSPO_RS06830	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PSPO_RS06835	COG0492	ferredoxin-NADP+ reductase activity
PSPO_RS06840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PSPO_RS06845	COG0686	Belongs to the AlaDH PNT family
PSPO_RS06855	COG0531	amino acid
PSPO_RS06855	COG1674	ftsk spoiiie
PSPO_RS06860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PSPO_RS06865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PSPO_RS06870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PSPO_RS06875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PSPO_RS06885	COG0577	efflux transmembrane transporter activity
PSPO_RS06885	COG1136	(ABC) transporter
PSPO_RS06890	COG0577	efflux transmembrane transporter activity
PSPO_RS06890	COG1136	(ABC) transporter
PSPO_RS06900	COG4191	Histidine kinase
PSPO_RS06910	COG0735	belongs to the Fur family
PSPO_RS06930	COG0596	Alpha beta hydrolase
PSPO_RS06935	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PSPO_RS06940	COG0033	Phosphoglucomutase
PSPO_RS06945	COG2988	succinylglutamate desuccinylase activity
PSPO_RS06955	COG0022	dehydrogenase e1 component
PSPO_RS06980	COG4555	ABC transporter
PSPO_RS06985	COG1668	transmembrane transport
PSPO_RS06990	COG2885	chlorophyll binding
PSPO_RS07115	COG1704	LemA family
PSPO_RS07130	COG0367	asparagine synthase
PSPO_RS07140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PSPO_RS07150	COG4770	biotin carboxylase activity
PSPO_RS07155	COG1024	Enoyl-CoA hydratase
PSPO_RS07160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PSPO_RS07165	COG1960	acyl-CoA dehydrogenase activity
PSPO_RS07175	COG0183	Belongs to the thiolase family
PSPO_RS07185	COG1960	acyl-CoA dehydrogenase activity
PSPO_RS07190	COG1024	Enoyl-CoA hydratase
PSPO_RS07195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PSPO_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS07215	COG3130	regulation of translation
PSPO_RS07220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PSPO_RS07235	COG1607	acyl-coa hydrolase
PSPO_RS07245	COG2056	Na+-H+ antiporter family
PSPO_RS07260	COG0714	Associated with various cellular activities
PSPO_RS07270	COG1054	Belongs to the UPF0176 family
PSPO_RS07275	COG0513	Belongs to the DEAD box helicase family
PSPO_RS07280	COG2996	Protein conserved in bacteria
PSPO_RS07290	COG0284	orotidine-5'-phosphate decarboxylase activity
PSPO_RS07295	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PSPO_RS07305	COG0776	regulation of translation
PSPO_RS07310	COG0539	negative regulation of cytoplasmic translation
PSPO_RS07315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PSPO_RS07320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PSPO_RS07325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PSPO_RS07335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PSPO_RS07350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PSPO_RS07375	COG0281	malic enzyme
PSPO_RS07405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PSPO_RS07410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PSPO_RS07420	COG0501	Belongs to the peptidase M48B family
PSPO_RS07425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PSPO_RS07430	COG2226	methyltransferase
PSPO_RS07440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PSPO_RS07445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PSPO_RS07445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PSPO_RS07460	COG0017	Asparaginyl-tRNA synthetase
PSPO_RS07485	COG1720	tRNA m6t6A37 methyltransferase activity
PSPO_RS07490	COG0442	prolyl-tRNA aminoacylation
PSPO_RS07495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PSPO_RS07510	COG0045	succinate-CoA ligase (ADP-forming) activity
PSPO_RS07515	COG0508	dehydrogenase complex catalyzes the overall conversion of
PSPO_RS07520	COG0567	Dehydrogenase, E1 component
PSPO_RS07530	COG1053	succinate dehydrogenase
PSPO_RS07535	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PSPO_RS07550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PSPO_RS07555	COG2166	iron-sulfur cluster assembly
PSPO_RS07560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PSPO_RS07565	COG0564	pseudouridine synthase activity
PSPO_RS07570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PSPO_RS07575	COG2835	tetraacyldisaccharide 4'-kinase activity
PSPO_RS07580	COG1663	tetraacyldisaccharide 4'-kinase activity
PSPO_RS07585	COG1132	(ABC) transporter
PSPO_RS07590	COG2333	competence protein COMEC
PSPO_RS07590	COG0658	competence protein
PSPO_RS07620	COG0488	(ABC) transporter
PSPO_RS07630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PSPO_RS07630	COG0116	Belongs to the methyltransferase superfamily
PSPO_RS07640	COG0167	dihydroorotate dehydrogenase activity
PSPO_RS07645	COG2902	Dehydrogenase
PSPO_RS07675	COG0308	aminopeptidase N
PSPO_RS07680	COG1757	Na H antiporter
PSPO_RS07690	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PSPO_RS07700	COG1956	GAF domain-containing protein
PSPO_RS07720	COG0670	Belongs to the BI1 family
PSPO_RS07745	COG0545	Peptidyl-prolyl cis-trans isomerase
PSPO_RS07765	COG0471	metal ion transport
PSPO_RS07770	COG1472	Belongs to the glycosyl hydrolase 3 family
PSPO_RS07775	COG0778	Nitroreductase
PSPO_RS07785	COG1902	pentaerythritol trinitrate reductase activity
PSPO_RS07785	COG0446	pyridine nucleotide-disulphide oxidoreductase
PSPO_RS07790	COG0616	signal peptide processing
PSPO_RS07795	COG0252	asparaginase activity
PSPO_RS07800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSPO_RS07810	COG0469	pyruvate kinase activity
PSPO_RS07835	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PSPO_RS07860	COG2828	Protein conserved in bacteria
PSPO_RS07865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PSPO_RS07870	COG0372	Belongs to the citrate synthase family
PSPO_RS07875	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PSPO_RS07930	COG0700	Nucleoside recognition
PSPO_RS07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PSPO_RS07935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PSPO_RS07945	COG0084	hydrolase, TatD family'
PSPO_RS07960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PSPO_RS07965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PSPO_RS07975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PSPO_RS07980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PSPO_RS07990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PSPO_RS07995	COG0416	fatty acid biosynthetic process
PSPO_RS08000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PSPO_RS08005	COG1399	metal-binding, possibly nucleic acid-binding protein
PSPO_RS08010	COG0424	maF-like protein
PSPO_RS08015	COG0546	phosphoglycolate phosphatase activity
PSPO_RS08020	COG0564	pseudouridine synthase activity
PSPO_RS08025	COG1530	ribonuclease E activity
PSPO_RS08035	COG3081	Nucleoid-associated protein
PSPO_RS08040	COG3082	Protein of unknown function (DUF1414)
PSPO_RS08045	COG3083	sulfuric ester hydrolase activity
PSPO_RS08060	COG3139	Protein of unknown function (DUF1315)
PSPO_RS08070	COG1115	amino acid carrier protein
PSPO_RS08075	COG2866	Carboxypeptidase
PSPO_RS08090	COG0776	regulation of translation
PSPO_RS08095	COG0072	phenylalanine-tRNA ligase activity
PSPO_RS08155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PSPO_RS08160	COG0322	excinuclease ABC activity
PSPO_RS08165	COG2197	response regulator
PSPO_RS08170	COG1283	sodium-dependent phosphate transmembrane transporter activity
PSPO_RS08180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PSPO_RS08190	COG1960	acyl-CoA dehydrogenase activity
PSPO_RS08215	COG1131	(ABC) transporter
PSPO_RS08225	COG0626	cystathionine gamma-synthase activity
PSPO_RS08235	COG0363	glucosamine-6-phosphate deaminase activity
PSPO_RS08245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PSPO_RS08250	COG2971	BadF BadG BcrA BcrD
PSPO_RS08255	COG4109	DRTGG domain
PSPO_RS08275	COG2925	Exonuclease
PSPO_RS08285	COG0840	transmembrane signaling receptor activity
PSPO_RS08290	COG2084	Dehydrogenase
PSPO_RS08295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PSPO_RS08300	COG2095	MarC family integral membrane protein
PSPO_RS08305	COG0733	neurotransmitter:sodium symporter activity
PSPO_RS08315	COG0527	aspartate kinase activity
PSPO_RS08370	COG0418	dihydroorotase activity
PSPO_RS08375	COG3291	Pkd domain containing protein
PSPO_RS08380	COG2203	Gaf domain
PSPO_RS08380	COG3706	GGDEF domain
PSPO_RS08380	COG4251	negative regulation of phosphorylation
PSPO_RS08380	COG5001	Diguanylate cyclase
PSPO_RS08390	COG0583	DNA-binding transcription factor activity
PSPO_RS08395	COG0628	permease
PSPO_RS08400	COG1090	epimerase
PSPO_RS08405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PSPO_RS08410	COG4181	ATPase activity
PSPO_RS08435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PSPO_RS08445	COG1301	dicarboxylic acid transport
PSPO_RS08450	COG0616	signal peptide processing
PSPO_RS08455	COG2267	carboxylic ester hydrolase activity
PSPO_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS08480	COG4783	chaperone-mediated protein folding
PSPO_RS08485	COG1393	Belongs to the ArsC family
PSPO_RS08505	COG0564	pseudouridine synthase activity
PSPO_RS08510	COG3098	single-species biofilm formation
PSPO_RS08540	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PSPO_RS08550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PSPO_RS08550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PSPO_RS08560	COG2911	Protein conserved in bacteria
PSPO_RS08575	COG3706	GGDEF domain
PSPO_RS08580	COG2201	protein-glutamate methylesterase activity
PSPO_RS08585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PSPO_RS08590	COG0563	adenylate kinase activity
PSPO_RS08595	COG1966	Carbon starvation protein
PSPO_RS08600	COG0326	Molecular chaperone. Has ATPase activity
PSPO_RS08610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PSPO_RS08615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PSPO_RS08630	COG2205	protein histidine kinase activity
PSPO_RS08645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PSPO_RS08645	COG0116	Belongs to the methyltransferase superfamily
PSPO_RS08650	COG0556	nucleotide-excision repair
PSPO_RS08655	COG0534	Mate efflux family protein
PSPO_RS08680	COG2200	EAL domain
PSPO_RS08685	COG4657	Part of a membrane complex involved in electron transport
PSPO_RS08700	COG4658	electron transport chain
PSPO_RS08705	COG4659	FMN binding
PSPO_RS08710	COG4660	Part of a membrane complex involved in electron transport
PSPO_RS08715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PSPO_RS08725	COG0346	lactoylglutathione lyase activity
PSPO_RS08730	COG1357	PFAM Pentapeptide repeats (8 copies)
PSPO_RS08810	COG0745	RESPONSE REGULATOR receiver
PSPO_RS08845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PSPO_RS08850	COG3115	cell septum assembly
PSPO_RS08855	COG1196	nuclear chromosome segregation
PSPO_RS08860	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PSPO_RS08865	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PSPO_RS08870	COG2363	Small membrane protein
PSPO_RS08880	COG0583	DNA-binding transcription factor activity
PSPO_RS08890	COG2212	antiporter activity
PSPO_RS08895	COG1863	multisubunit Na H antiporter MnhE subunit
PSPO_RS08900	COG0651	ATP synthesis coupled electron transport
PSPO_RS08905	COG1006	Multisubunit Na H antiporter MnhC subunit
PSPO_RS08910	COG2111	Na H antiporter
PSPO_RS08910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PSPO_RS08925	COG1185	polyribonucleotide nucleotidyltransferase activity
PSPO_RS08930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PSPO_RS08935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PSPO_RS08940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PSPO_RS08945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PSPO_RS08950	COG0195	Participates in both transcription termination and antitermination
PSPO_RS08955	COG0779	Required for maturation of 30S ribosomal subunits
PSPO_RS08975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PSPO_RS08980	COG0514	ATP-dependent DNA helicase (RecQ)
PSPO_RS08995	COG1404	Belongs to the peptidase S8 family
PSPO_RS09035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PSPO_RS09045	COG1215	transferase activity, transferring glycosyl groups
PSPO_RS09050	COG3769	mannosylglycerate metabolic process
PSPO_RS09055	COG0183	Belongs to the thiolase family
PSPO_RS09060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PSPO_RS09065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PSPO_RS09070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PSPO_RS09080	COG3220	belongs to the UPF0276 family
PSPO_RS09090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PSPO_RS09120	COG0848	biopolymer transport protein
PSPO_RS09125	COG0811	peptide transport
PSPO_RS09130	COG0811	peptide transport
PSPO_RS09145	COG4206	TonB-dependent receptor
PSPO_RS09150	COG0417	DNA replication proofreading
PSPO_RS09155	COG1199	ATP-dependent helicase activity
PSPO_RS09170	COG0123	including yeast histone deacetylase and acetoin utilization protein
PSPO_RS09210	COG1136	(ABC) transporter
PSPO_RS09215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS09240	COG2356	endonuclease I
PSPO_RS09250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PSPO_RS09330	COG3706	GGDEF domain
PSPO_RS09345	COG0825	malonyl-CoA metabolic process
PSPO_RS09350	COG0587	DNA-directed DNA polymerase activity
PSPO_RS09355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PSPO_RS09360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PSPO_RS09365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PSPO_RS09370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PSPO_RS09375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PSPO_RS09390	COG0750	zinc metalloprotease
PSPO_RS09395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PSPO_RS09400	COG0575	Belongs to the CDS family
PSPO_RS09405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PSPO_RS09410	COG0233	cytoplasmic translational termination
PSPO_RS09415	COG0528	UMP kinase activity
PSPO_RS09420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PSPO_RS09425	COG0052	Belongs to the universal ribosomal protein uS2 family
PSPO_RS09430	COG0024	Methionine aminopeptidase
PSPO_RS09435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PSPO_RS09440	COG2171	N-acyltransferase activity
PSPO_RS09445	COG2154	pterin-4-alpha-carbinolamine dehydratase
PSPO_RS09460	COG3768	UPF0283 membrane protein
PSPO_RS09465	COG3106	COG3106 Predicted ATPase
PSPO_RS09470	COG1983	PspC domain protein
PSPO_RS09480	COG1842	Phage shock protein A
PSPO_RS09485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PSPO_RS09490	COG4166	transmembrane transport
PSPO_RS09495	COG4168	peptide transport system, permease
PSPO_RS09500	COG4171	peptide transport system, permease
PSPO_RS09505	COG4172	Belongs to the ABC transporter superfamily
PSPO_RS09510	COG4172	Belongs to the ABC transporter superfamily
PSPO_RS09515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSPO_RS09525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PSPO_RS09530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PSPO_RS09535	COG0740	serine-type endopeptidase activity
PSPO_RS09540	COG0544	peptidyl-prolyl cis-trans isomerase activity
PSPO_RS09570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PSPO_RS09575	COG0215	cysteine-tRNA ligase activity
PSPO_RS09580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PSPO_RS09600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PSPO_RS09605	COG1286	toxin biosynthetic process
PSPO_RS09615	COG0285	dihydrofolate synthase activity
PSPO_RS09620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PSPO_RS09625	COG0101	tRNA pseudouridine synthase activity
PSPO_RS09640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PSPO_RS09645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PSPO_RS09650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PSPO_RS09650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PSPO_RS09655	COG3291	Pkd domain containing protein
PSPO_RS09660	COG0517	IMP dehydrogenase activity
PSPO_RS09675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PSPO_RS09720	COG1166	arginine decarboxylase activity
PSPO_RS09725	COG0010	Belongs to the arginase family
PSPO_RS09740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PSPO_RS09745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PSPO_RS09750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PSPO_RS09755	COG0006	proline dipeptidase activity
PSPO_RS09760	COG3079	Belongs to the UPF0149 family
PSPO_RS09825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PSPO_RS09835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PSPO_RS09840	COG2813	Specifically methylates the guanine in position
PSPO_RS09850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PSPO_RS09850	COG4191	Histidine kinase
PSPO_RS09860	COG0745	RESPONSE REGULATOR receiver
PSPO_RS09865	COG0784	Response regulator, receiver
PSPO_RS09865	COG5002	protein histidine kinase activity
PSPO_RS09865	COG2198	Histidine kinase
PSPO_RS09880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PSPO_RS09900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PSPO_RS09905	COG0739	heme binding
PSPO_RS09920	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
PSPO_RS09930	COG3630	sodium ion export across plasma membrane
PSPO_RS09965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PSPO_RS09975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PSPO_RS09980	COG2137	regulation of response to DNA damage stimulus
PSPO_RS09990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PSPO_RS10050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PSPO_RS10095	COG2975	iron-sulfur cluster assembly
PSPO_RS10105	COG0525	valine-tRNA ligase activity
PSPO_RS10110	COG2927	DNA polymerase III (CHI subunit)
PSPO_RS10115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PSPO_RS10120	COG0795	lipopolysaccharide-transporting ATPase activity
PSPO_RS10125	COG0795	lipopolysaccharide-transporting ATPase activity
PSPO_RS10165	COG3118	belongs to the thioredoxin family
PSPO_RS10170	COG1473	amidohydrolase
PSPO_RS10190	COG3938	Belongs to the proline racemase family
PSPO_RS10210	COG0577	efflux transmembrane transporter activity
PSPO_RS10210	COG1136	(ABC) transporter
PSPO_RS10215	COG1136	(ABC) transporter
PSPO_RS10225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PSPO_RS10250	COG4774	siderophore transport
PSPO_RS10250	COG1629	transport
PSPO_RS10255	COG1360	Flagellar Motor Protein
PSPO_RS10260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PSPO_RS10265	COG1722	exodeoxyribonuclease VII activity
PSPO_RS10270	COG0142	geranyltranstransferase activity
PSPO_RS10275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PSPO_RS10280	COG3706	GGDEF domain
PSPO_RS10285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PSPO_RS10290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PSPO_RS10295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PSPO_RS10300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PSPO_RS10315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PSPO_RS10315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PSPO_RS10320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PSPO_RS10325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PSPO_RS10330	COG1752	Esterase of the alpha-beta hydrolase superfamily
PSPO_RS10335	COG0488	(ABC) transporter
PSPO_RS10340	COG0705	Rhomboid family
PSPO_RS10360	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
PSPO_RS10365	COG0204	Acyl-transferase
PSPO_RS10380	COG3150	esterase
PSPO_RS10395	COG0494	nUDIX hydrolase
PSPO_RS10400	COG1538	Outer membrane efflux protein
PSPO_RS10405	COG1560	Kdo2-lipid A biosynthetic process
PSPO_RS10415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PSPO_RS10430	COG1131	(ABC) transporter
PSPO_RS10435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PSPO_RS10440	COG0189	ligase activity
PSPO_RS10445	COG1678	Uncharacterized ACR, COG1678
PSPO_RS10450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PSPO_RS10470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PSPO_RS10475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PSPO_RS10480	COG0762	integral membrane protein
PSPO_RS10490	COG1785	Belongs to the alkaline phosphatase family
PSPO_RS10495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PSPO_RS10500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PSPO_RS10510	COG0039	L-malate dehydrogenase activity
PSPO_RS10515	COG1438	arginine binding
PSPO_RS10525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PSPO_RS10535	COG1840	ABC-type Fe3 transport system, periplasmic component
PSPO_RS10540	COG3148	PFAM DTW domain containing protein
PSPO_RS10545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PSPO_RS10550	COG0508	dehydrogenase complex catalyzes the overall conversion of
PSPO_RS10555	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PSPO_RS10560	COG2186	Transcriptional regulator
PSPO_RS10570	COG3023	N-Acetylmuramoyl-L-alanine amidase
PSPO_RS10595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSPO_RS10600	COG1459	type II secretion system
PSPO_RS10605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PSPO_RS10610	COG0237	dephospho-CoA kinase activity
PSPO_RS10615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PSPO_RS10620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PSPO_RS10635	COG0745	RESPONSE REGULATOR receiver
PSPO_RS10640	COG2205	protein histidine kinase activity
PSPO_RS10645	COG2267	carboxylic ester hydrolase activity
PSPO_RS10655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PSPO_RS10660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PSPO_RS10665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PSPO_RS10670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PSPO_RS10675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PSPO_RS10680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PSPO_RS10685	COG4942	peptidase
PSPO_RS10690	COG0793	Belongs to the peptidase S41A family
PSPO_RS10715	COG0840	transmembrane signaling receptor activity
PSPO_RS10720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PSPO_RS10725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PSPO_RS10735	COG3279	Response regulator of the LytR AlgR family
PSPO_RS10755	COG1477	protein flavinylation
PSPO_RS10760	COG2871	sodium ion transport
PSPO_RS10765	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSPO_RS10770	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSPO_RS10775	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSPO_RS10780	COG1805	sodium ion transport
PSPO_RS10785	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PSPO_RS10790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PSPO_RS10795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
PSPO_RS10805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PSPO_RS10810	COG0271	Belongs to the BolA IbaG family
PSPO_RS10820	COG2813	Specifically methylates the guanine in position
PSPO_RS10830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PSPO_RS10835	COG2814	Major facilitator Superfamily
PSPO_RS10855	COG0316	Belongs to the HesB IscA family
PSPO_RS10865	COG1981	membrane
PSPO_RS10870	COG0540	Belongs to the ATCase OTCase family
PSPO_RS10875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PSPO_RS10880	COG0840	transmembrane signaling receptor activity
PSPO_RS10885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PSPO_RS10895	COG0667	Aldo Keto reductase
PSPO_RS10910	COG1643	Atp-dependent helicase
PSPO_RS10920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PSPO_RS10935	COG0745	RESPONSE REGULATOR receiver
PSPO_RS10940	COG0004	ammonium transporteR
PSPO_RS10950	COG3275	phosphorelay sensor kinase activity
PSPO_RS10965	COG3279	Response regulator of the LytR AlgR family
PSPO_RS10990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PSPO_RS10995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PSPO_RS11000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PSPO_RS11005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PSPO_RS11015	COG0560	Phosphoserine phosphatase
PSPO_RS11025	COG0084	hydrolase, TatD family'
PSPO_RS11030	COG0259	pyridoxamine-phosphate oxidase activity
PSPO_RS11050	COG0018	arginyl-trna synthetase
PSPO_RS11060	COG1131	(ABC) transporter
PSPO_RS11120	COG2205	protein histidine kinase activity
PSPO_RS11120	COG0784	Response regulator, receiver
PSPO_RS11125	COG0456	acetyltransferase
PSPO_RS11140	COG3706	GGDEF domain
PSPO_RS11145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PSPO_RS11145	COG0519	Catalyzes the synthesis of GMP from XMP
PSPO_RS11150	COG0516	GMP reductase activity
PSPO_RS11150	COG0517	IMP dehydrogenase activity
PSPO_RS11155	COG1570	exodeoxyribonuclease VII activity
PSPO_RS11175	COG2814	Major facilitator Superfamily
PSPO_RS11195	COG0612	Peptidase, M16
PSPO_RS11210	COG0646	methionine synthase
PSPO_RS11210	COG1410	methionine synthase
PSPO_RS11215	COG1410	methionine synthase
PSPO_RS11215	COG0646	methionine synthase
PSPO_RS11220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PSPO_RS11240	COG1629	transport
PSPO_RS11240	COG4774	siderophore transport
PSPO_RS11245	COG2176	DNA-directed DNA polymerase activity
PSPO_RS11250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PSPO_RS11250	COG0517	IMP dehydrogenase activity
PSPO_RS11255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PSPO_RS11265	COG0784	Response regulator, receiver
PSPO_RS11265	COG2198	Histidine kinase
PSPO_RS11265	COG2205	protein histidine kinase activity
PSPO_RS11275	COG0788	formyltetrahydrofolate deformylase activity
PSPO_RS11310	COG0443	Heat shock 70 kDa protein
PSPO_RS11315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PSPO_RS11325	COG0822	iron-sulfur transferase activity
PSPO_RS11330	COG1104	cysteine desulfurase activity
PSPO_RS11335	COG1959	2 iron, 2 sulfur cluster binding
PSPO_RS11355	COG2199	diguanylate cyclase activity
PSPO_RS11355	COG2203	Gaf domain
PSPO_RS11355	COG2200	EAL domain
PSPO_RS11365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PSPO_RS11370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PSPO_RS11375	COG1862	Preprotein translocase
PSPO_RS11380	COG0343	queuine tRNA-ribosyltransferase activity
PSPO_RS11385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PSPO_RS11390	COG5002	protein histidine kinase activity
PSPO_RS11390	COG5001	Diguanylate cyclase
PSPO_RS11410	COG1595	DNA-templated transcription, initiation
PSPO_RS11415	COG0583	DNA-binding transcription factor activity
PSPO_RS11420	COG0306	phosphate transporter
PSPO_RS11425	COG1392	Phosphate transport regulator
PSPO_RS11430	COG0704	Plays a role in the regulation of phosphate uptake
PSPO_RS11435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PSPO_RS11440	COG0573	inorganic phosphate transmembrane transporter activity
PSPO_RS11455	COG0076	glutamate decarboxylase activity
PSPO_RS11460	COG3287	FIST C domain
PSPO_RS11460	COG2200	EAL domain
PSPO_RS11460	COG2199	diguanylate cyclase activity
PSPO_RS11465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PSPO_RS11470	COG0842	Transport permease protein
PSPO_RS11475	COG1131	(ABC) transporter
PSPO_RS11480	COG0163	prenyltransferase activity
PSPO_RS11485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PSPO_RS11495	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PSPO_RS11505	COG2003	Belongs to the UPF0758 family
PSPO_RS11510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PSPO_RS11520	COG1506	peptidase
PSPO_RS11520	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS11520	COG4946	Tricorn protease homolog
PSPO_RS11525	COG1032	radical SAM domain protein
PSPO_RS11530	COG3300	MHYT domain
PSPO_RS11530	COG5001	Diguanylate cyclase
PSPO_RS11565	COG1842	Phage shock protein A
PSPO_RS11575	COG0735	belongs to the Fur family
PSPO_RS11585	COG0432	Pfam Uncharacterised protein family UPF0047
PSPO_RS11590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PSPO_RS11595	COG0305	Participates in initiation and elongation during chromosome replication
PSPO_RS11630	COG4969	Belongs to the N-Me-Phe pilin family
PSPO_RS11640	COG0359	binds to the 23S rRNA
PSPO_RS11645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PSPO_RS11650	COG2965	DNA replication, synthesis of RNA primer
PSPO_RS11655	COG0360	Binds together with S18 to 16S ribosomal RNA
PSPO_RS11660	COG1528	Iron-storage protein
PSPO_RS11665	COG0678	peroxiredoxin activity
PSPO_RS11665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PSPO_RS11675	COG0742	ribosomal rna small subunit methyltransferase
PSPO_RS11680	COG0745	RESPONSE REGULATOR receiver
PSPO_RS11685	COG0339	signal peptide processing
PSPO_RS11690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PSPO_RS11695	COG0745	RESPONSE REGULATOR receiver
PSPO_RS11710	COG2205	protein histidine kinase activity
PSPO_RS11730	COG4948	Mandelate Racemase Muconate Lactonizing
PSPO_RS11740	COG1505	serine-type exopeptidase activity
PSPO_RS11760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PSPO_RS11765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PSPO_RS11770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PSPO_RS11775	COG1561	YicC-like family, N-terminal region
PSPO_RS11805	COG3620	sequence-specific DNA binding
PSPO_RS11875	COG0720	synthase
PSPO_RS11905	COG0514	ATP-dependent DNA helicase (RecQ)
PSPO_RS11925	COG0514	ATP-dependent DNA helicase (RecQ)
PSPO_RS11930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PSPO_RS11935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PSPO_RS11945	COG2203	Gaf domain
PSPO_RS11945	COG3706	GGDEF domain
PSPO_RS11945	COG4251	negative regulation of phosphorylation
PSPO_RS11945	COG5001	Diguanylate cyclase
PSPO_RS11960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PSPO_RS11965	COG1136	(ABC) transporter
PSPO_RS11980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PSPO_RS11990	COG1227	inorganic diphosphatase activity
PSPO_RS11995	COG3706	GGDEF domain
PSPO_RS12000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PSPO_RS12020	COG2897	thiosulfate sulfurtransferase activity
PSPO_RS12050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS12055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSPO_RS12065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSPO_RS12070	COG4206	TonB-dependent receptor
PSPO_RS12175	COG1666	GTP binding
PSPO_RS12180	COG1666	GTP binding
PSPO_RS12190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PSPO_RS12195	COG0301	tRNA thio-modification
PSPO_RS12195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PSPO_RS12200	COG0612	Peptidase, M16
PSPO_RS12210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSPO_RS12215	COG0557	exoribonuclease II activity
PSPO_RS12220	COG1234	tRNA 3'-trailer cleavage
PSPO_RS12235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PSPO_RS12245	COG0069	glutamate synthase activity
PSPO_RS12255	COG1404	Belongs to the peptidase S8 family
PSPO_RS12280	COG0047	phosphoribosylformylglycinamidine synthase activity
PSPO_RS12280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PSPO_RS12285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PSPO_RS12295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PSPO_RS12305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PSPO_RS12315	COG3706	GGDEF domain
PSPO_RS12320	COG2962	Rard protein
PSPO_RS12325	COG0514	ATP-dependent DNA helicase (RecQ)
PSPO_RS12335	COG0402	S-adenosylhomocysteine deaminase activity
PSPO_RS12350	COG1131	(ABC) transporter
PSPO_RS12360	COG2081	HI0933 family
PSPO_RS12365	COG2863	cytochrome
PSPO_RS12370	COG3122	Protein conserved in bacteria
PSPO_RS12380	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
PSPO_RS12390	COG2226	methyltransferase
PSPO_RS12405	COG0584	glycerophosphoryl diester phosphodiesterase
PSPO_RS12415	COG0840	transmembrane signaling receptor activity
PSPO_RS12420	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PSPO_RS12425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PSPO_RS12430	COG1509	lysine 2,3-aminomutase activity
PSPO_RS12465	COG0459	protein refolding
PSPO_RS12470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PSPO_RS12485	COG4232	protein-disulfide reductase activity
PSPO_RS12490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PSPO_RS12495	COG0511	ligase activity, forming carbon-carbon bonds
PSPO_RS12500	COG0439	Biotin carboxylase
PSPO_RS12510	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PSPO_RS12515	COG1765	OsmC-like protein
PSPO_RS12525	COG1012	belongs to the aldehyde dehydrogenase family
PSPO_RS12535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PSPO_RS12550	COG0180	Tryptophanyl-tRNA synthetase
PSPO_RS12555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PSPO_RS12570	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PSPO_RS12580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PSPO_RS12585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PSPO_RS12615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PSPO_RS12620	COG0460	homoserine dehydrogenase
PSPO_RS12620	COG0527	aspartate kinase activity
PSPO_RS12625	COG0626	cystathionine gamma-synthase activity
PSPO_RS12630	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
PSPO_RS12635	COG0281	malic enzyme
PSPO_RS12640	COG0254	rRNA binding
PSPO_RS12645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PSPO_RS12650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PSPO_RS12655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PSPO_RS12660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PSPO_RS12670	COG0840	transmembrane signaling receptor activity
PSPO_RS12680	COG0671	phosphoesterase, PA-phosphatase related
PSPO_RS12685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PSPO_RS12700	COG1228	amidohydrolase
PSPO_RS12705	COG2188	Transcriptional regulator
PSPO_RS12710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PSPO_RS12760	COG0405	Gamma-glutamyltransferase
PSPO_RS12765	COG0494	nUDIX hydrolase
PSPO_RS12770	COG0653	protein targeting
PSPO_RS12800	COG3078	GTPase activator activity
PSPO_RS12815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PSPO_RS12820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PSPO_RS12820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PSPO_RS12825	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PSPO_RS12835	COG5001	Diguanylate cyclase
PSPO_RS12855	COG0288	reversible hydration of carbon dioxide
PSPO_RS12865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PSPO_RS12870	COG0129	dihydroxy-acid dehydratase activity
PSPO_RS12875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PSPO_RS12880	COG3978	acetolactate synthase activity
PSPO_RS12920	COG0019	diaminopimelate decarboxylase activity
PSPO_RS12935	COG1217	gtp-binding protein TYPA
PSPO_RS12940	COG0174	glutamine synthetase
PSPO_RS12950	COG3852	Histidine kinase
PSPO_RS12975	COG0745	RESPONSE REGULATOR receiver
PSPO_RS12980	COG0583	DNA-binding transcription factor activity
PSPO_RS12985	COG2814	Major facilitator Superfamily
PSPO_RS13015	COG2885	chlorophyll binding
PSPO_RS13020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PSPO_RS13025	COG3107	peptidoglycan biosynthetic process
PSPO_RS13030	COG0792	nuclease activity
PSPO_RS13040	COG2823	Periplasmic or secreted lipoprotein
PSPO_RS13055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PSPO_RS13060	COG2969	positive regulation of protein catabolic process
PSPO_RS13065	COG0625	glutathione transferase activity
PSPO_RS13070	COG2857	Cytochrome c1
PSPO_RS13075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PSPO_RS13080	COG0723	plastoquinol--plastocyanin reductase activity
PSPO_RS13090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PSPO_RS13095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PSPO_RS13110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PSPO_RS13120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PSPO_RS13130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PSPO_RS13135	COG5007	Belongs to the BolA IbaG family
PSPO_RS13145	COG2854	intermembrane phospholipid transfer
PSPO_RS13150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PSPO_RS13155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PSPO_RS13160	COG1127	ABC transporter
PSPO_RS13175	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PSPO_RS13190	COG1137	ATPase activity
PSPO_RS13195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PSPO_RS13200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PSPO_RS13205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PSPO_RS13210	COG1660	Displays ATPase and GTPase activities
PSPO_RS13215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PSPO_RS13220	COG2239	Acts as a magnesium transporter
PSPO_RS13225	COG0456	acetyltransferase
PSPO_RS13235	COG1490	D-aminoacyl-tRNA deacylase activity
PSPO_RS13240	COG1295	ribonuclease BN
PSPO_RS13255	COG4946	Tricorn protease homolog
PSPO_RS13255	COG1506	peptidase
PSPO_RS13255	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS13260	COG4206	TonB-dependent receptor
PSPO_RS13270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PSPO_RS13280	COG2072	flavoprotein involved in K transport
PSPO_RS13315	COG1049	propionate catabolic process, 2-methylcitrate cycle
PSPO_RS13330	COG2423	ornithine cyclodeaminase activity
PSPO_RS13335	COG0006	proline dipeptidase activity
PSPO_RS13345	COG1858	cytochrome C peroxidase
PSPO_RS13360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSPO_RS13365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS13395	COG0629	single-stranded DNA binding
PSPO_RS13400	COG2814	Major facilitator Superfamily
PSPO_RS13405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PSPO_RS13435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PSPO_RS13440	COG2183	response to ionizing radiation
PSPO_RS13455	COG0596	Alpha beta hydrolase
PSPO_RS13460	COG1040	competence protein
PSPO_RS13470	COG0316	Belongs to the HesB IscA family
PSPO_RS13470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PSPO_RS13480	COG0534	Mate efflux family protein
PSPO_RS13490	COG2201	protein-glutamate methylesterase activity
PSPO_RS13495	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PSPO_RS13500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PSPO_RS13510	COG0835	chemotaxis
PSPO_RS13515	COG0643	Histidine kinase
PSPO_RS13515	COG2198	Histidine kinase
PSPO_RS13530	COG1999	signal sequence binding
PSPO_RS13535	COG0109	protoheme IX farnesyltransferase activity
PSPO_RS13540	COG1612	heme a metabolic process
PSPO_RS13560	COG1845	cytochrome c oxidase, subunit III
PSPO_RS13565	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PSPO_RS13570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PSPO_RS13575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PSPO_RS13580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PSPO_RS13585	COG2937	Belongs to the GPAT DAPAT family
PSPO_RS13590	COG1946	Acyl-CoA thioesterase
PSPO_RS13615	COG2199	diguanylate cyclase activity
PSPO_RS13620	COG5001	Diguanylate cyclase
PSPO_RS13625	COG2226	methyltransferase
PSPO_RS13630	COG3165	ubiquinone biosynthetic process from chorismate
PSPO_RS13635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PSPO_RS13645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PSPO_RS13650	COG0805	protein transport
PSPO_RS13660	COG0084	hydrolase, TatD family'
PSPO_RS13680	COG1648	precorrin-2 dehydrogenase activity
PSPO_RS13680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PSPO_RS13685	COG0175	sulfate reduction
PSPO_RS13695	COG3273	potassium ion transport
PSPO_RS13695	COG0471	metal ion transport
PSPO_RS13700	COG0529	Catalyzes the synthesis of activated sulfate
PSPO_RS13710	COG0745	RESPONSE REGULATOR receiver
PSPO_RS13745	COG0330	HflC and HflK could
PSPO_RS13755	COG1187	pseudouridine synthase activity
PSPO_RS13765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS13775	COG0640	Transcriptional regulator
PSPO_RS13800	COG3275	phosphorelay sensor kinase activity
PSPO_RS13810	COG0668	transmembrane transport
PSPO_RS13815	COG0204	Acyl-transferase
PSPO_RS13820	COG0204	Acyl-transferase
PSPO_RS13825	COG1166	arginine decarboxylase activity
PSPO_RS13830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PSPO_RS13850	COG1082	Xylose isomerase domain protein TIM barrel
PSPO_RS13865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PSPO_RS13870	COG4681	YaeQ
PSPO_RS13880	COG0783	Belongs to the Dps family
PSPO_RS13895	COG4152	abc transporter atp-binding protein
PSPO_RS13930	COG2198	Histidine kinase
PSPO_RS13930	COG5002	protein histidine kinase activity
PSPO_RS13930	COG0784	Response regulator, receiver
PSPO_RS13935	COG3437	response regulator, receiver
PSPO_RS13940	COG1506	peptidase
PSPO_RS13940	COG4946	Tricorn protease homolog
PSPO_RS13940	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS13950	COG4771	TonB-dependent receptor
PSPO_RS13955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PSPO_RS13965	COG1349	DNA-binding transcription factor activity
PSPO_RS13970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PSPO_RS13995	COG0676	glucose-6-phosphate 1-epimerase activity
PSPO_RS14045	COG2354	Protein conserved in bacteria
PSPO_RS14050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PSPO_RS14055	COG0813	purine-nucleoside phosphorylase activity
PSPO_RS14095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PSPO_RS14120	COG0745	RESPONSE REGULATOR receiver
PSPO_RS14125	COG2205	protein histidine kinase activity
PSPO_RS14135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PSPO_RS14155	COG0386	Belongs to the glutathione peroxidase family
PSPO_RS14160	COG0583	DNA-binding transcription factor activity
PSPO_RS14165	COG1979	alcohol dehydrogenase
PSPO_RS14200	COG1238	metal cluster binding
PSPO_RS14205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PSPO_RS14210	COG0302	gtp cyclohydrolase
PSPO_RS14230	COG3706	GGDEF domain
PSPO_RS14245	COG1228	amidohydrolase
PSPO_RS14270	COG0784	Response regulator, receiver
PSPO_RS14270	COG2205	protein histidine kinase activity
PSPO_RS14285	COG3710	Transcriptional regulator
PSPO_RS14310	COG1725	Transcriptional regulator
PSPO_RS14315	COG1131	(ABC) transporter
PSPO_RS14340	COG3706	GGDEF domain
PSPO_RS14365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PSPO_RS14375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PSPO_RS14385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PSPO_RS14390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PSPO_RS14395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PSPO_RS14400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PSPO_RS14410	COG0356	it plays a direct role in the translocation of protons across the membrane
PSPO_RS14415	COG3312	ion transport
PSPO_RS14420	COG1475	DNA binding
PSPO_RS14425	COG1192	Involved in chromosome partitioning
PSPO_RS14430	COG0357	Ribosomal RNA small subunit methyltransferase G
PSPO_RS14435	COG0445	tRNA wobble uridine modification
PSPO_RS14440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PSPO_RS14455	COG4592	Periplasmic binding protein
PSPO_RS14460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PSPO_RS14465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PSPO_RS14470	COG1120	ATPase activity
PSPO_RS14475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PSPO_RS14485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PSPO_RS14490	COG0706	membrane insertase activity
PSPO_RS14495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PSPO_RS14500	COG0594	ribonuclease P activity
PSPO_RS14505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PSPO_RS14510	COG1192	Involved in chromosome partitioning
PSPO_RS14520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PSPO_RS14535	COG1322	Protein conserved in bacteria
PSPO_RS14575	COG3562	capsule polysaccharide
PSPO_RS14595	COG0848	biopolymer transport protein
PSPO_RS14600	COG0811	peptide transport
PSPO_RS14620	COG2986	histidine ammonia-lyase
PSPO_RS14625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PSPO_RS14640	COG0123	including yeast histone deacetylase and acetoin utilization protein
PSPO_RS14650	COG0644	oxidoreductase
PSPO_RS14680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PSPO_RS14690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PSPO_RS14695	COG0813	purine-nucleoside phosphorylase activity
PSPO_RS14705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PSPO_RS14740	COG0741	lytic transglycosylase activity
PSPO_RS14740	COG0739	heme binding
PSPO_RS14740	COG1196	nuclear chromosome segregation
PSPO_RS14785	COG1404	Belongs to the peptidase S8 family
PSPO_RS14805	COG0339	signal peptide processing
PSPO_RS14815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PSPO_RS14830	COG0697	spore germination
PSPO_RS14845	COG0784	Response regulator, receiver
PSPO_RS14845	COG2205	protein histidine kinase activity
PSPO_RS14855	COG0583	DNA-binding transcription factor activity
PSPO_RS14860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PSPO_RS14885	COG0697	spore germination
PSPO_RS14905	COG2610	gluconate transmembrane transporter activity
PSPO_RS14910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PSPO_RS14915	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS14920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PSPO_RS14925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PSPO_RS14940	COG1131	(ABC) transporter
PSPO_RS14950	COG1309	transcriptional regulator
PSPO_RS14975	COG2249	NAD(P)H dehydrogenase (quinone) activity
PSPO_RS14980	COG1733	regulation of RNA biosynthetic process
PSPO_RS15005	COG0523	cobalamin synthesis protein
PSPO_RS15090	COG0745	RESPONSE REGULATOR receiver
PSPO_RS15095	COG5002	protein histidine kinase activity
PSPO_RS15100	COG2165	general secretion pathway protein
PSPO_RS15115	COG0415	Belongs to the DNA photolyase family
PSPO_RS15120	COG0415	Belongs to the DNA photolyase family
PSPO_RS15130	COG3046	protein related to deoxyribodipyrimidine photolyase
PSPO_RS15190	COG1942	4-Oxalocrotonate Tautomerase
PSPO_RS15200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSPO_RS15200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PSPO_RS15220	COG0583	DNA-binding transcription factor activity
PSPO_RS15230	COG4942	peptidase
PSPO_RS15275	COG1757	Na H antiporter
PSPO_RS15295	COG2932	Transcriptional regulator
PSPO_RS15310	COG2133	pyrroloquinoline quinone binding
PSPO_RS15350	COG4774	siderophore transport
PSPO_RS15370	COG4977	sequence-specific DNA binding
PSPO_RS15370	COG1917	Cupin 2, conserved barrel domain protein
PSPO_RS15375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PSPO_RS15385	COG2356	endonuclease I
PSPO_RS15395	COG0778	Nitroreductase
PSPO_RS15430	COG1131	(ABC) transporter
PSPO_RS15435	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
PSPO_RS15450	COG2169	Transcriptional regulator
PSPO_RS15465	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PSPO_RS15470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PSPO_RS15480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PSPO_RS15485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PSPO_RS15490	COG0235	Class ii aldolase
PSPO_RS15495	COG0436	Aminotransferase
PSPO_RS15500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PSPO_RS15520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PSPO_RS15605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PSPO_RS15610	COG2204	response regulator
PSPO_RS15615	COG1215	transferase activity, transferring glycosyl groups
PSPO_RS15640	COG0438	transferase activity, transferring glycosyl groups
PSPO_RS15665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PSPO_RS15675	COG2885	chlorophyll binding
PSPO_RS15725	COG4191	Histidine kinase
PSPO_RS15740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSPO_RS15755	COG0679	Auxin Efflux Carrier
PSPO_RS15765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PSPO_RS15770	COG1846	Transcriptional regulator
PSPO_RS15780	COG4251	negative regulation of phosphorylation
PSPO_RS15785	COG2205	protein histidine kinase activity
PSPO_RS15785	COG0784	Response regulator, receiver
PSPO_RS15790	COG5002	protein histidine kinase activity
PSPO_RS15790	COG5001	Diguanylate cyclase
PSPO_RS15790	COG3447	MASE1 domain protein
PSPO_RS15810	COG0583	DNA-binding transcription factor activity
PSPO_RS15820	COG1196	nuclear chromosome segregation
PSPO_RS15820	COG3264	Mechanosensitive ion channel
PSPO_RS15835	COG0189	ligase activity
PSPO_RS15860	COG1640	4-alpha-glucanotransferase
PSPO_RS15875	COG0058	SHG alpha-glucan phosphorylase activity
PSPO_RS15880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PSPO_RS15885	COG0297	glycogen (starch) synthase activity
PSPO_RS15905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSPO_RS15950	COG0454	-acetyltransferase
PSPO_RS15950	COG0456	acetyltransferase
PSPO_RS15975	COG1404	Belongs to the peptidase S8 family
PSPO_RS15995	COG1309	transcriptional regulator
PSPO_RS16020	COG1797	cobyrinic acid a,c-diamide synthase activity
PSPO_RS16025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PSPO_RS16030	COG3724	N-succinylarginine dihydrolase activity
PSPO_RS16035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PSPO_RS16040	COG0583	DNA-binding transcription factor activity
PSPO_RS16050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PSPO_RS16060	COG1881	PFAM PEBP family protein
PSPO_RS16065	COG2211	Major facilitator Superfamily
PSPO_RS16070	COG3119	arylsulfatase activity
PSPO_RS16110	COG1252	NADH dehydrogenase
PSPO_RS16130	COG0840	transmembrane signaling receptor activity
PSPO_RS16135	COG0840	transmembrane signaling receptor activity
PSPO_RS16140	COG2824	Alkylphosphonate utilization operon protein PhnA
PSPO_RS16155	COG0583	DNA-binding transcription factor activity
PSPO_RS16180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PSPO_RS16185	COG0840	transmembrane signaling receptor activity
PSPO_RS16205	COG1462	curli production assembly transport component CsgG
PSPO_RS16235	COG0791	NLP P60 protein
PSPO_RS16245	COG0431	NADPH-dependent FMN reductase
PSPO_RS16270	COG2059	Chromate
PSPO_RS16275	COG0583	DNA-binding transcription factor activity
PSPO_RS16340	COG1476	TRANSCRIPTIONal
PSPO_RS16350	COG3064	Membrane
PSPO_RS16350	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PSPO_RS16350	COG1073	alpha beta
PSPO_RS16360	COG1064	alcohol dehydrogenase
PSPO_RS16420	COG0515	serine threonine protein kinase
PSPO_RS16420	COG2815	serine threonine protein kinase
PSPO_RS16450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PSPO_RS16460	COG3537	Alpha-1,2-mannosidase
PSPO_RS16465	COG3537	Alpha-1,2-mannosidase
PSPO_RS16470	COG1609	Transcriptional regulator
PSPO_RS16510	COG3275	phosphorelay sensor kinase activity
PSPO_RS16515	COG3279	Response regulator of the LytR AlgR family
PSPO_RS16520	COG0583	DNA-binding transcription factor activity
PSPO_RS16530	COG0848	biopolymer transport protein
PSPO_RS16550	COG4774	siderophore transport
PSPO_RS16600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PSPO_RS16615	COG0668	transmembrane transport
PSPO_RS16625	COG1671	Belongs to the UPF0178 family
PSPO_RS16630	COG0534	Mate efflux family protein
PSPO_RS16655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PSPO_RS16660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PSPO_RS16670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PSPO_RS16675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PSPO_RS16720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PSPO_RS16730	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS16735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PSPO_RS16750	COG4628	conserved protein (DUF2132)
PSPO_RS16780	COG1012	belongs to the aldehyde dehydrogenase family
PSPO_RS16785	COG1309	transcriptional regulator
PSPO_RS16795	COG4206	TonB-dependent receptor
PSPO_RS16805	COG4946	Tricorn protease homolog
PSPO_RS16805	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS16805	COG1506	peptidase
PSPO_RS16825	COG1285	pathogenesis
PSPO_RS16830	COG1253	flavin adenine dinucleotide binding
PSPO_RS16840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PSPO_RS16850	COG1280	lysine exporter protein (LysE YggA)
PSPO_RS16885	COG0678	peroxiredoxin activity
PSPO_RS16885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PSPO_RS16910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PSPO_RS16930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PSPO_RS16950	COG0583	DNA-binding transcription factor activity
PSPO_RS16970	COG0625	glutathione transferase activity
PSPO_RS16975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PSPO_RS17010	COG0737	Belongs to the 5'-nucleotidase family
PSPO_RS17015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PSPO_RS17035	COG0625	glutathione transferase activity
PSPO_RS17050	COG3008	intermembrane lipid transfer
PSPO_RS17050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PSPO_RS17055	COG2995	paraquat-inducible protein a
PSPO_RS17060	COG1454	alcohol dehydrogenase
PSPO_RS17095	COG0457	Tetratricopeptide repeat
PSPO_RS17095	COG3710	Transcriptional regulator
PSPO_RS17125	COG0840	transmembrane signaling receptor activity
PSPO_RS17140	COG0840	transmembrane signaling receptor activity
PSPO_RS17145	COG0840	transmembrane signaling receptor activity
PSPO_RS17170	COG1760	l-serine dehydratase
PSPO_RS17175	COG0745	RESPONSE REGULATOR receiver
PSPO_RS17180	COG0784	Response regulator, receiver
PSPO_RS17180	COG5002	protein histidine kinase activity
PSPO_RS17190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PSPO_RS17200	COG0006	proline dipeptidase activity
PSPO_RS17205	COG1230	cation diffusion facilitator family transporter
PSPO_RS17210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PSPO_RS17230	COG0848	biopolymer transport protein
PSPO_RS17235	COG0811	peptide transport
PSPO_RS17240	COG0811	peptide transport
PSPO_RS17250	COG2226	methyltransferase
PSPO_RS17285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PSPO_RS17295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PSPO_RS17310	COG1477	protein flavinylation
PSPO_RS17345	COG1902	pentaerythritol trinitrate reductase activity
PSPO_RS17355	COG1278	Cold shock
PSPO_RS17360	COG3483	tryptophan 2,3-dioxygenase activity
PSPO_RS17405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PSPO_RS17420	COG0574	Belongs to the PEP-utilizing enzyme family
PSPO_RS17420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PSPO_RS17425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PSPO_RS17430	COG0254	rRNA binding
PSPO_RS17450	COG0247	lactate metabolic process
PSPO_RS17450	COG0277	FAD linked oxidase domain protein
PSPO_RS17475	COG2197	response regulator
PSPO_RS17480	COG4585	Histidine kinase
PSPO_RS17505	COG0840	transmembrane signaling receptor activity
PSPO_RS17510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PSPO_RS17515	COG1506	peptidase
PSPO_RS17515	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS17515	COG4946	Tricorn protease homolog
PSPO_RS17550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PSPO_RS17570	COG2193	ferroxidase activity
PSPO_RS17575	COG1960	acyl-CoA dehydrogenase activity
PSPO_RS17595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PSPO_RS17600	COG0513	Belongs to the DEAD box helicase family
PSPO_RS17605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PSPO_RS17615	COG1187	pseudouridine synthase activity
PSPO_RS17645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PSPO_RS17655	COG0840	transmembrane signaling receptor activity
PSPO_RS17660	COG0494	nUDIX hydrolase
PSPO_RS17690	COG1199	ATP-dependent helicase activity
PSPO_RS17700	COG1785	Belongs to the alkaline phosphatase family
PSPO_RS17705	COG2267	carboxylic ester hydrolase activity
PSPO_RS17710	COG0318	PFAM AMP-dependent synthetase and ligase
PSPO_RS17715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PSPO_RS17720	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PSPO_RS17725	COG2894	cell division
PSPO_RS17730	COG0850	regulation of cytokinetic process
PSPO_RS17735	COG3100	YcgL domain-containing protein
PSPO_RS17740	COG2951	lytic endotransglycosylase activity
PSPO_RS17745	COG2983	Belongs to the UPF0260 family
PSPO_RS17750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PSPO_RS17760	COG0811	peptide transport
PSPO_RS17765	COG0811	peptide transport
PSPO_RS17770	COG0848	biopolymer transport protein
PSPO_RS17775	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PSPO_RS17810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PSPO_RS17845	COG1733	regulation of RNA biosynthetic process
PSPO_RS17890	COG4974	Belongs to the 'phage' integrase family
PSPO_RS17915	COG0784	Response regulator, receiver
PSPO_RS17915	COG2205	protein histidine kinase activity
PSPO_RS17925	COG0302	gtp cyclohydrolase
PSPO_RS17945	COG0513	Belongs to the DEAD box helicase family
PSPO_RS17985	COG1611	Belongs to the LOG family
PSPO_RS17990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PSPO_RS18005	COG0473	3-isopropylmalate dehydrogenase activity
PSPO_RS18010	COG4946	Tricorn protease homolog
PSPO_RS18010	COG1506	peptidase
PSPO_RS18010	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS18015	COG0028	Belongs to the TPP enzyme family
PSPO_RS18055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PSPO_RS18060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PSPO_RS18065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PSPO_RS18075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PSPO_RS18075	COG0131	Imidazoleglycerol-phosphate dehydratase
PSPO_RS18080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PSPO_RS18085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PSPO_RS18090	COG0107	imidazoleglycerol-phosphate synthase activity
PSPO_RS18095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PSPO_RS18095	COG0140	phosphoribosyl-ATP diphosphatase activity
PSPO_RS18105	COG0840	transmembrane signaling receptor activity
PSPO_RS18115	COG0484	heat shock protein binding
PSPO_RS18120	COG0443	Heat shock 70 kDa protein
PSPO_RS18140	COG4269	membrane
PSPO_RS18145	COG0501	Belongs to the peptidase M48B family
PSPO_RS18160	COG1492	cobalamin metabolic process
PSPO_RS18165	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PSPO_RS18170	COG0295	cytidine deaminase activity
PSPO_RS18205	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PSPO_RS18215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PSPO_RS18250	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PSPO_RS18255	COG1435	thymidine kinase activity
PSPO_RS18265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PSPO_RS18270	COG0454	-acetyltransferase
PSPO_RS18290	COG2384	SAM-dependent methyltransferase
PSPO_RS18360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSPO_RS18365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS18390	COG2382	esterase
PSPO_RS18405	COG1840	ABC-type Fe3 transport system, periplasmic component
PSPO_RS18415	COG0488	(ABC) transporter
PSPO_RS18425	COG2133	pyrroloquinoline quinone binding
PSPO_RS18440	COG0840	transmembrane signaling receptor activity
PSPO_RS18455	COG1522	sequence-specific DNA binding
PSPO_RS18475	COG1271	oxidase subunit
PSPO_RS18480	COG1294	oxidase, subunit
PSPO_RS18500	COG1404	Belongs to the peptidase S8 family
PSPO_RS18535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PSPO_RS18545	COG2912	Transglutaminase-like superfamily
PSPO_RS18550	COG3094	Invasion gene expression up-regulator, SirB
PSPO_RS18555	COG3437	response regulator, receiver
PSPO_RS18555	COG0784	Response regulator, receiver
PSPO_RS18560	COG2890	protein-(glutamine-N5) methyltransferase activity
PSPO_RS18565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PSPO_RS18570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PSPO_RS18575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PSPO_RS18580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PSPO_RS18585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PSPO_RS18605	COG1162	GTPase activity
PSPO_RS18615	COG0577	efflux transmembrane transporter activity
PSPO_RS18620	COG1136	(ABC) transporter
PSPO_RS18625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS18660	COG0784	Response regulator, receiver
PSPO_RS18660	COG3437	response regulator, receiver
PSPO_RS18670	COG0840	transmembrane signaling receptor activity
PSPO_RS18675	COG0513	Belongs to the DEAD box helicase family
PSPO_RS18685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PSPO_RS18690	COG2199	diguanylate cyclase activity
PSPO_RS18695	COG3590	peptidase
PSPO_RS18705	COG0583	DNA-binding transcription factor activity
PSPO_RS18720	COG0443	Heat shock 70 kDa protein
PSPO_RS18750	COG0513	Belongs to the DEAD box helicase family
PSPO_RS18775	COG0745	RESPONSE REGULATOR receiver
PSPO_RS18790	COG4792	protein secretion
PSPO_RS18795	COG4791	protein targeting
PSPO_RS18800	COG4794	Type iii secretion
PSPO_RS18805	COG4790	Type iii secretion
PSPO_RS18810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PSPO_RS18830	COG4789	Type iii secretion
PSPO_RS18970	COG0745	RESPONSE REGULATOR receiver
PSPO_RS18975	COG2205	protein histidine kinase activity
PSPO_RS18985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS18990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSPO_RS19000	COG0456	acetyltransferase
PSPO_RS19010	COG0488	(ABC) transporter
PSPO_RS19025	COG2202	Pas domain
PSPO_RS19025	COG2199	diguanylate cyclase activity
PSPO_RS19025	COG2200	EAL domain
PSPO_RS19030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PSPO_RS19035	COG5001	Diguanylate cyclase
PSPO_RS19035	COG2203	Gaf domain
PSPO_RS19035	COG4251	negative regulation of phosphorylation
PSPO_RS19035	COG3706	GGDEF domain
PSPO_RS19065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PSPO_RS19070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PSPO_RS19075	COG2188	Transcriptional regulator
PSPO_RS19080	COG3706	GGDEF domain
PSPO_RS19115	COG2205	protein histidine kinase activity
PSPO_RS19125	COG2204	response regulator
PSPO_RS19135	COG3038	cytochrome b561
PSPO_RS19145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PSPO_RS19155	COG4206	TonB-dependent receptor
PSPO_RS19160	COG0583	DNA-binding transcription factor activity
PSPO_RS19170	COG4948	Mandelate Racemase Muconate Lactonizing
PSPO_RS19195	COG4682	membrane
PSPO_RS19205	COG2843	Capsule synthesis protein
PSPO_RS19220	COG2199	diguanylate cyclase activity
PSPO_RS19225	COG2356	endonuclease I
PSPO_RS19230	COG1280	lysine exporter protein (LysE YggA)
PSPO_RS19235	COG0702	epimerase
PSPO_RS19260	COG5640	endopeptidase activity
PSPO_RS19265	COG0745	RESPONSE REGULATOR receiver
PSPO_RS19275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PSPO_RS19280	COG2205	protein histidine kinase activity
PSPO_RS19280	COG0784	Response regulator, receiver
PSPO_RS19280	COG5002	protein histidine kinase activity
PSPO_RS19290	COG0513	Belongs to the DEAD box helicase family
PSPO_RS19335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PSPO_RS19340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PSPO_RS19355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PSPO_RS19360	COG1737	Transcriptional regulator
PSPO_RS19420	COG0583	DNA-binding transcription factor activity
PSPO_RS19445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PSPO_RS19465	COG1757	Na H antiporter
PSPO_RS19470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PSPO_RS19485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PSPO_RS19515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PSPO_RS19520	COG0505	Belongs to the CarA family
PSPO_RS19525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PSPO_RS19545	COG4977	sequence-specific DNA binding
PSPO_RS19550	COG0738	Major facilitator superfamily
PSPO_RS19555	COG1940	carbohydrate kinase activity
PSPO_RS19585	COG5001	Diguanylate cyclase
PSPO_RS19585	COG4251	negative regulation of phosphorylation
PSPO_RS19585	COG2203	Gaf domain
PSPO_RS19585	COG3706	GGDEF domain
PSPO_RS19600	COG1472	Belongs to the glycosyl hydrolase 3 family
PSPO_RS19610	COG1172	Belongs to the binding-protein-dependent transport system permease family
PSPO_RS19615	COG1879	ABC-type sugar transport system periplasmic component
PSPO_RS19620	COG1940	carbohydrate kinase activity
PSPO_RS19620	COG1846	Transcriptional regulator
PSPO_RS19625	COG0840	transmembrane signaling receptor activity
PSPO_RS19645	COG0583	DNA-binding transcription factor activity
PSPO_RS19650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PSPO_RS19700	COG0726	polysaccharide deacetylase
PSPO_RS19740	COG1335	isochorismatase
PSPO_RS19755	COG1629	transport
PSPO_RS19755	COG4774	siderophore transport
PSPO_RS19765	COG2009	succinate dehydrogenase
PSPO_RS19790	COG3655	Transcriptional regulator
PSPO_RS19810	COG0563	adenylate kinase activity
PSPO_RS19825	COG4774	siderophore transport
PSPO_RS19835	COG0596	Alpha beta hydrolase
PSPO_RS19840	COG1454	alcohol dehydrogenase
PSPO_RS19855	COG1368	sulfuric ester hydrolase activity
PSPO_RS19890	COG0583	DNA-binding transcription factor activity
PSPO_RS19900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PSPO_RS19925	COG0625	glutathione transferase activity
PSPO_RS19945	COG0583	DNA-binding transcription factor activity
PSPO_RS19950	COG2910	NAD(P)H-binding
PSPO_RS19965	COG2130	NADP-dependent
PSPO_RS19975	COG0583	DNA-binding transcription factor activity
PSPO_RS20010	COG0604	alcohol dehydrogenase
PSPO_RS20015	COG1309	transcriptional regulator
PSPO_RS20030	COG0730	response to heat
PSPO_RS20035	COG0513	Belongs to the DEAD box helicase family
PSPO_RS20075	COG2311	Membrane
PSPO_RS20090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PSPO_RS20105	COG3119	arylsulfatase activity
PSPO_RS20140	COG2304	oxidoreductase activity
PSPO_RS20165	COG0754	glutathionylspermidine amidase activity
PSPO_RS20170	COG5463	Belongs to the UPF0441 family
PSPO_RS20185	COG1842	Phage shock protein A
PSPO_RS20190	COG3789	protein conserved in bacteria
PSPO_RS20200	COG0640	Transcriptional regulator
PSPO_RS20205	COG0798	PFAM Bile acid sodium symporter
PSPO_RS20270	COG2205	protein histidine kinase activity
PSPO_RS20275	COG0745	RESPONSE REGULATOR receiver
PSPO_RS20315	COG0583	DNA-binding transcription factor activity
PSPO_RS20345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PSPO_RS20345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PSPO_RS20350	COG0509	glycine decarboxylation via glycine cleavage system
PSPO_RS20355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PSPO_RS20365	COG0583	DNA-binding transcription factor activity
PSPO_RS20380	COG0300	oxidoreductase activity
PSPO_RS20385	COG2972	Histidine kinase
PSPO_RS20390	COG3279	Response regulator of the LytR AlgR family
PSPO_RS20400	COG3119	arylsulfatase activity
PSPO_RS20410	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PSPO_RS20420	COG1017	nitric oxide dioxygenase activity
PSPO_RS20420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PSPO_RS20435	COG3604	Transcriptional regulator
PSPO_RS20440	COG1228	amidohydrolase
PSPO_RS20475	COG4774	siderophore transport
PSPO_RS20515	COG0583	DNA-binding transcription factor activity
PSPO_RS20525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PSPO_RS20560	COG4335	DNA alkylation repair
PSPO_RS20565	COG2066	Belongs to the glutaminase family
PSPO_RS20605	COG0789	Transcriptional regulator
PSPO_RS20615	COG0823	Involved in the tonB-independent uptake of proteins
PSPO_RS20615	COG1506	peptidase
PSPO_RS20630	COG3036	rescue of stalled ribosome
PSPO_RS20660	COG1136	(ABC) transporter
PSPO_RS20660	COG0577	efflux transmembrane transporter activity
PSPO_RS20670	COG2204	response regulator
PSPO_RS20675	COG5000	phosphorelay sensor kinase activity
PSPO_RS20735	COG1902	pentaerythritol trinitrate reductase activity
PSPO_RS20750	COG1794	racemase activity, acting on amino acids and derivatives
PSPO_RS20815	COG1944	ATP diphosphatase activity
PSPO_RS20825	COG1597	lipid kinase activity
PSPO_RS20825	COG1803	Methylglyoxal synthase
PSPO_RS20830	COG2204	response regulator
PSPO_RS20840	COG4251	negative regulation of phosphorylation
PSPO_RS20845	COG0784	Response regulator, receiver
PSPO_RS20850	COG0784	Response regulator, receiver
PSPO_RS20850	COG2205	protein histidine kinase activity
PSPO_RS20860	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PSPO_RS20865	COG2823	Periplasmic or secreted lipoprotein
PSPO_RS20870	COG0668	transmembrane transport
PSPO_RS20900	COG1902	pentaerythritol trinitrate reductase activity
PSPO_RS20910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PSPO_RS20940	COG1280	lysine exporter protein (LysE YggA)
PSPO_RS20980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PSPO_RS21010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PSPO_RS21010	COG4191	Histidine kinase
PSPO_RS21015	COG0784	Response regulator, receiver
PSPO_RS21015	COG3437	response regulator, receiver
PSPO_RS21020	COG1396	sequence-specific DNA binding
PSPO_RS21075	COG2203	Gaf domain
PSPO_RS21075	COG3706	GGDEF domain
PSPO_RS21075	COG4251	negative regulation of phosphorylation
PSPO_RS21075	COG5001	Diguanylate cyclase
PSPO_RS21090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PSPO_RS21140	COG0519	Catalyzes the synthesis of GMP from XMP
PSPO_RS21145	COG0456	acetyltransferase
PSPO_RS21145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PSPO_RS21190	COG1683	Conserved Protein
PSPO_RS21210	COG1028	Short-chain dehydrogenase reductase Sdr
PSPO_RS21220	COG1309	transcriptional regulator
PSPO_RS21230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PSPO_RS21245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PSPO_RS21250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PSPO_RS21255	COG0577	efflux transmembrane transporter activity
PSPO_RS21255	COG1136	(ABC) transporter
PSPO_RS21275	COG1136	(ABC) transporter
PSPO_RS21275	COG0577	efflux transmembrane transporter activity
PSPO_RS21320	COG0242	peptide deformylase activity
PSPO_RS21330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PSPO_RS21335	COG1288	antiporter activity
PSPO_RS21355	COG3135	benzoate transporter
PSPO_RS21360	COG1396	sequence-specific DNA binding
PSPO_RS21365	COG0789	Transcriptional regulator
PSPO_RS21385	COG1858	cytochrome C peroxidase
PSPO_RS21415	COG0583	DNA-binding transcription factor activity
PSPO_RS21425	COG3706	GGDEF domain
PSPO_RS21445	COG2819	hydrolase of the alpha beta superfamily
PSPO_RS21475	COG0346	lactoylglutathione lyase activity
PSPO_RS21510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase