locus-tag	class	description
I5154_RS00020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5154_RS00055	COG2909	trisaccharide binding
I5154_RS00060	COG2909	trisaccharide binding
I5154_RS00100	COG4067	protein conserved in archaea
I5154_RS00100	COG0189	ligase activity
I5154_RS00135	COG0668	transmembrane transport
I5154_RS00155	COG0243	molybdopterin cofactor binding
I5154_RS00160	COG2146	nitrite reductase [NAD(P)H] activity
I5154_RS00165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5154_RS00170	COG0515	serine threonine protein kinase
I5154_RS00175	COG2223	nitrite transmembrane transporter activity
I5154_RS00185	COG3707	response regulator
I5154_RS00205	COG0589	response to stress
I5154_RS00225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5154_RS00415	COG2932	Transcriptional regulator
I5154_RS00460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5154_RS00545	COG4626	Terminase
I5154_RS00545	COG1802	Transcriptional regulator
I5154_RS00555	COG4695	Portal protein
I5154_RS00560	COG0740	serine-type endopeptidase activity
I5154_RS00685	COG3179	chitinase
I5154_RS00720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5154_RS00725	COG2205	protein histidine kinase activity
I5154_RS00730	COG0745	RESPONSE REGULATOR receiver
I5154_RS00735	COG3344	reverse transcriptase
I5154_RS00755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5154_RS00770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5154_RS00780	COG4172	Belongs to the ABC transporter superfamily
I5154_RS00785	COG4239	(ABC) transporter, permease
I5154_RS00790	COG4174	ABC transporter (Permease)
I5154_RS00795	COG4166	transmembrane transport
I5154_RS00800	COG4166	transmembrane transport
I5154_RS00805	COG1388	LysM domain
I5154_RS00805	COG0741	lytic transglycosylase activity
I5154_RS00825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5154_RS00840	COG0531	amino acid
I5154_RS00850	COG1024	Enoyl-CoA hydratase
I5154_RS00875	COG0583	DNA-binding transcription factor activity
I5154_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS00905	COG0616	signal peptide processing
I5154_RS00910	COG0604	alcohol dehydrogenase
I5154_RS00935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5154_RS00995	COG3813	Protein conserved in bacteria
I5154_RS01000	COG4977	sequence-specific DNA binding
I5154_RS01005	COG2203	Gaf domain
I5154_RS01005	COG5001	Diguanylate cyclase
I5154_RS01005	COG4251	negative regulation of phosphorylation
I5154_RS01005	COG3706	GGDEF domain
I5154_RS01020	COG2239	Acts as a magnesium transporter
I5154_RS01030	COG3278	Belongs to the heme-copper respiratory oxidase family
I5154_RS01035	COG2354	Protein conserved in bacteria
I5154_RS01040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5154_RS01050	COG0583	DNA-binding transcription factor activity
I5154_RS01055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I5154_RS01075	COG1309	transcriptional regulator
I5154_RS01145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS01190	COG0417	DNA replication proofreading
I5154_RS01210	COG0625	glutathione transferase activity
I5154_RS01225	COG2366	antibiotic biosynthetic process
I5154_RS01250	COG2197	response regulator
I5154_RS01300	COG2814	Major facilitator Superfamily
I5154_RS01320	COG3712	iron ion homeostasis
I5154_RS01325	COG1595	DNA-templated transcription, initiation
I5154_RS01355	COG0579	oxidoreductase
I5154_RS01370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5154_RS01370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5154_RS01375	COG0275	rRNA processing
I5154_RS01380	COG4771	TonB-dependent receptor
I5154_RS01400	COG1944	ATP diphosphatase activity
I5154_RS01425	COG2080	2 iron, 2 sulfur cluster binding
I5154_RS01430	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I5154_RS01435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5154_RS01460	COG0753	catalase activity
I5154_RS01465	COG2010	Cytochrome c
I5154_RS01480	COG2204	response regulator
I5154_RS01495	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5154_RS01500	COG1609	Transcriptional regulator
I5154_RS01505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5154_RS01555	COG1278	Cold shock
I5154_RS01560	COG0583	DNA-binding transcription factor activity
I5154_RS01575	COG0488	(ABC) transporter
I5154_RS01615	COG2194	sulfuric ester hydrolase activity
I5154_RS01635	COG0784	Response regulator, receiver
I5154_RS01635	COG2205	protein histidine kinase activity
I5154_RS01655	COG3851	Histidine kinase
I5154_RS01720	COG2205	protein histidine kinase activity
I5154_RS01740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5154_RS01745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5154_RS01750	COG0583	DNA-binding transcription factor activity
I5154_RS01755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5154_RS01770	COG2031	fatty acid transporter
I5154_RS01775	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS01780	COG2610	gluconate transmembrane transporter activity
I5154_RS01785	COG3290	protein histidine kinase activity
I5154_RS01785	COG3829	transcription factor binding
I5154_RS01790	COG2271	Major facilitator Superfamily
I5154_RS01800	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5154_RS01830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5154_RS01835	COG1960	acyl-CoA dehydrogenase activity
I5154_RS01840	COG0789	Transcriptional regulator
I5154_RS01845	COG3204	pilus organization
I5154_RS01855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS01860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS01905	COG1522	sequence-specific DNA binding
I5154_RS01925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5154_RS01940	COG0028	Belongs to the TPP enzyme family
I5154_RS01960	COG0174	glutamine synthetase
I5154_RS01965	COG0531	amino acid
I5154_RS01975	COG0564	pseudouridine synthase activity
I5154_RS01995	COG2207	Transcriptional regulator
I5154_RS02010	COG1595	DNA-templated transcription, initiation
I5154_RS02030	COG0583	DNA-binding transcription factor activity
I5154_RS02045	COG4771	TonB-dependent receptor
I5154_RS02055	COG4174	ABC transporter (Permease)
I5154_RS02060	COG4239	(ABC) transporter, permease
I5154_RS02065	COG4172	Belongs to the ABC transporter superfamily
I5154_RS02070	COG1104	cysteine desulfurase activity
I5154_RS02100	COG2814	Major facilitator Superfamily
I5154_RS02105	COG2192	nodulation
I5154_RS02120	COG5001	Diguanylate cyclase
I5154_RS02145	COG2010	Cytochrome c
I5154_RS02150	COG2010	Cytochrome c
I5154_RS02155	COG1113	amino acid transport
I5154_RS02170	COG1522	sequence-specific DNA binding
I5154_RS02180	COG0367	asparagine synthase
I5154_RS02185	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5154_RS02190	COG0596	Alpha beta hydrolase
I5154_RS02210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5154_RS02220	COG2814	Major facilitator Superfamily
I5154_RS02255	COG0300	oxidoreductase activity
I5154_RS02265	COG0028	Belongs to the TPP enzyme family
I5154_RS02275	COG1984	allophanate hydrolase subunit 2
I5154_RS02295	COG2814	Major facilitator Superfamily
I5154_RS02300	COG0583	DNA-binding transcription factor activity
I5154_RS02315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5154_RS02315	COG2169	Transcriptional regulator
I5154_RS02345	COG0583	DNA-binding transcription factor activity
I5154_RS02350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5154_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS02360	COG1475	DNA binding
I5154_RS02370	COG3969	phosphoadenosine phosphosulfate
I5154_RS02380	COG3121	Chaperone
I5154_RS02385	COG3188	usher protein
I5154_RS02395	COG3121	Chaperone
I5154_RS02415	COG2323	membrane
I5154_RS02445	COG1546	Belongs to the CinA family
I5154_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS02465	COG0058	SHG alpha-glucan phosphorylase activity
I5154_RS02490	COG1285	pathogenesis
I5154_RS02510	COG0366	Alpha amylase catalytic
I5154_RS02520	COG0392	lysyltransferase activity
I5154_RS02525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5154_RS02530	COG3568	Endonuclease Exonuclease Phosphatase
I5154_RS02570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5154_RS02605	COG1363	Peptidase, m42
I5154_RS02635	COG0784	Response regulator, receiver
I5154_RS02635	COG4191	Histidine kinase
I5154_RS02650	COG2890	protein-(glutamine-N5) methyltransferase activity
I5154_RS02680	COG0517	IMP dehydrogenase activity
I5154_RS02685	COG0366	Alpha amylase catalytic
I5154_RS02705	COG1309	transcriptional regulator
I5154_RS02710	COG2130	NADP-dependent
I5154_RS02720	COG2084	Dehydrogenase
I5154_RS02735	COG0765	amino acid transport
I5154_RS02740	COG0765	amino acid transport
I5154_RS02775	COG2271	Major facilitator Superfamily
I5154_RS02780	COG3618	amidohydrolase
I5154_RS02795	COG2271	Major facilitator Superfamily
I5154_RS02800	COG4948	Mandelate Racemase Muconate Lactonizing
I5154_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS02815	COG2995	paraquat-inducible protein a
I5154_RS02820	COG3008	intermembrane lipid transfer
I5154_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS02860	COG3162	membrane
I5154_RS02865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5154_RS02875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5154_RS02880	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS02885	COG0531	amino acid
I5154_RS02900	COG2072	flavoprotein involved in K transport
I5154_RS02915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS02935	COG2409	Drug exporters of the RND superfamily
I5154_RS02965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5154_RS02985	COG1247	-acetyltransferase
I5154_RS02995	COG4221	oxidoreductase activity
I5154_RS03000	COG2207	Transcriptional regulator
I5154_RS03035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I5154_RS03060	COG0210	DNA helicase
I5154_RS03070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5154_RS03070	COG0116	Belongs to the methyltransferase superfamily
I5154_RS03075	COG3264	Mechanosensitive ion channel
I5154_RS03075	COG1196	nuclear chromosome segregation
I5154_RS03085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5154_RS03100	COG0583	DNA-binding transcription factor activity
I5154_RS03105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5154_RS03160	COG0488	(ABC) transporter
I5154_RS03190	COG3300	MHYT domain
I5154_RS03190	COG5001	Diguanylate cyclase
I5154_RS03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS03205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS03220	COG2832	Protein of unknown function (DUF454)
I5154_RS03260	COG1987	bacterial-type flagellum assembly
I5154_RS03280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5154_RS03285	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5154_RS03315	COG0643	Histidine kinase
I5154_RS03315	COG2198	Histidine kinase
I5154_RS03315	COG0784	Response regulator, receiver
I5154_RS03325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5154_RS03330	COG1360	Flagellar Motor Protein
I5154_RS03335	COG1192	Involved in chromosome partitioning
I5154_RS03345	COG0835	chemotaxis
I5154_RS03360	COG2378	regulation of single-species biofilm formation
I5154_RS03370	COG1496	oxidoreductase activity
I5154_RS03375	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS03385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5154_RS03460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5154_RS03465	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5154_RS03480	COG3192	ethanolamine utilization protein
I5154_RS03490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5154_RS03505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5154_RS03510	COG4413	Urea transporter
I5154_RS03515	COG0469	pyruvate kinase activity
I5154_RS03525	COG2084	Dehydrogenase
I5154_RS03530	COG3622	Belongs to the hyi family
I5154_RS03535	COG3960	tartronate-semialdehyde synthase activity
I5154_RS03545	COG1309	transcriptional regulator
I5154_RS03560	COG2233	PERMEase
I5154_RS03605	COG0745	RESPONSE REGULATOR receiver
I5154_RS03615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5154_RS03630	COG0583	DNA-binding transcription factor activity
I5154_RS03635	COG2807	transmembrane transport
I5154_RS03655	COG0501	Belongs to the peptidase M48B family
I5154_RS03675	COG4208	sulfate ABC transporter
I5154_RS03685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5154_RS03705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5154_RS03720	COG2199	diguanylate cyclase activity
I5154_RS03745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5154_RS03750	COG0174	glutamine synthetase
I5154_RS03755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5154_RS03760	COG0174	glutamine synthetase
I5154_RS03780	COG3842	ATPase activity
I5154_RS03785	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5154_RS03790	COG1177	transmembrane transport
I5154_RS03840	COG0765	amino acid transport
I5154_RS03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5154_RS03860	COG0277	FAD linked oxidase domain protein
I5154_RS03865	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5154_RS03875	COG3111	PFAM Bacterial OB fold (BOF) protein
I5154_RS03885	COG0531	amino acid
I5154_RS03890	COG2182	Extracellular solute-binding protein
I5154_RS03895	COG1177	transmembrane transport
I5154_RS03905	COG3842	ATPase activity
I5154_RS03910	COG3204	pilus organization
I5154_RS03915	COG2234	aminopeptidase activity
I5154_RS03935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5154_RS03945	COG0702	epimerase
I5154_RS03985	COG0730	response to heat
I5154_RS04020	COG0584	glycerophosphoryl diester phosphodiesterase
I5154_RS04040	COG0622	Phosphoesterase
I5154_RS04045	COG2233	PERMEase
I5154_RS04060	COG0693	protein deglycase activity
I5154_RS04100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5154_RS04110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5154_RS04135	COG0429	hydrolase of the alpha beta-hydrolase fold
I5154_RS04145	COG0742	ribosomal rna small subunit methyltransferase
I5154_RS04150	COG0612	Peptidase, M16
I5154_RS04155	COG0612	Peptidase, M16
I5154_RS04160	COG0552	protein localization to endoplasmic reticulum
I5154_RS04165	COG2884	Cell division ATP-binding protein ftsE
I5154_RS04170	COG2177	Part of the ABC transporter FtsEX involved in
I5154_RS04190	COG2363	Small membrane protein
I5154_RS04225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5154_RS04240	COG2813	Specifically methylates the guanine in position
I5154_RS04240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5154_RS04250	COG1160	GTP binding
I5154_RS04255	COG1872	DUF167
I5154_RS04300	COG0626	cystathionine gamma-synthase activity
I5154_RS04365	COG0643	Histidine kinase
I5154_RS04365	COG0784	Response regulator, receiver
I5154_RS04365	COG2198	Histidine kinase
I5154_RS04395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5154_RS04410	COG3038	cytochrome b561
I5154_RS04440	COG0513	Belongs to the DEAD box helicase family
I5154_RS04450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5154_RS04455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5154_RS04480	COG1309	transcriptional regulator
I5154_RS04485	COG0402	S-adenosylhomocysteine deaminase activity
I5154_RS04490	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5154_RS04500	COG0493	'glutamate synthase
I5154_RS04510	COG1953	Uracil, thiamine, allantoin
I5154_RS04525	COG1960	acyl-CoA dehydrogenase activity
I5154_RS04530	COG0583	DNA-binding transcription factor activity
I5154_RS04540	COG0306	phosphate transporter
I5154_RS04550	COG0330	HflC and HflK could
I5154_RS04560	COG1289	transmembrane transporter activity
I5154_RS04565	COG0513	Belongs to the DEAD box helicase family
I5154_RS04575	COG4067	protein conserved in archaea
I5154_RS04575	COG0189	ligase activity
I5154_RS04580	COG0477	Major facilitator Superfamily
I5154_RS04585	COG0542	response to heat
I5154_RS04595	COG0204	Acyl-transferase
I5154_RS04605	COG0745	RESPONSE REGULATOR receiver
I5154_RS04610	COG2205	protein histidine kinase activity
I5154_RS04615	COG4452	Inner membrane protein CreD
I5154_RS04645	COG4774	siderophore transport
I5154_RS04650	COG3712	iron ion homeostasis
I5154_RS04655	COG1595	DNA-templated transcription, initiation
I5154_RS04660	COG0625	glutathione transferase activity
I5154_RS04670	COG1309	transcriptional regulator
I5154_RS04675	COG1953	Uracil, thiamine, allantoin
I5154_RS04695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5154_RS04730	COG2005	Transcriptional regulator
I5154_RS04730	COG3585	molybdate ion transport
I5154_RS04735	COG5544	Lipoprotein
I5154_RS04740	COG1040	competence protein
I5154_RS04760	COG0511	ligase activity, forming carbon-carbon bonds
I5154_RS04775	COG1984	allophanate hydrolase subunit 2
I5154_RS04795	COG1073	alpha beta
I5154_RS04795	COG2226	methyltransferase
I5154_RS04815	COG1960	acyl-CoA dehydrogenase activity
I5154_RS04820	COG1960	acyl-CoA dehydrogenase activity
I5154_RS04825	COG1960	acyl-CoA dehydrogenase activity
I5154_RS04835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5154_RS04835	COG1648	precorrin-2 dehydrogenase activity
I5154_RS04920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5154_RS04925	COG0583	DNA-binding transcription factor activity
I5154_RS04930	COG2258	MOSC domain
I5154_RS04940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5154_RS04960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS04970	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5154_RS05025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5154_RS05030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5154_RS05040	COG3622	Belongs to the hyi family
I5154_RS05045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5154_RS05085	COG2081	HI0933 family
I5154_RS05090	COG1451	nucleotide metabolic process
I5154_RS05095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5154_RS05100	COG3152	Membrane
I5154_RS05105	COG1917	Cupin 2, conserved barrel domain protein
I5154_RS05105	COG4977	sequence-specific DNA binding
I5154_RS05110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5154_RS05210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5154_RS05230	COG2719	SpoVR family
I5154_RS05240	COG2766	serine protein kinase
I5154_RS05280	COG3344	reverse transcriptase
I5154_RS05295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5154_RS05310	COG2197	response regulator
I5154_RS05320	COG3842	ATPase activity
I5154_RS05330	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5154_RS05340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5154_RS05365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5154_RS05450	COG3179	chitinase
I5154_RS05485	COG1765	OsmC-like protein
I5154_RS05500	COG0537	adenosine 5'-monophosphoramidase activity
I5154_RS05525	COG1981	membrane
I5154_RS05555	COG0739	heme binding
I5154_RS05720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5154_RS05845	COG2814	Major facilitator Superfamily
I5154_RS05870	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5154_RS05880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5154_RS05880	COG3433	isochorismatase activity
I5154_RS05880	COG2226	methyltransferase
I5154_RS05885	COG2226	methyltransferase
I5154_RS05885	COG3433	isochorismatase activity
I5154_RS05885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5154_RS05975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS05990	COG2706	6-phosphogluconolactonase activity
I5154_RS06010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5154_RS06015	COG1960	acyl-CoA dehydrogenase activity
I5154_RS06025	COG4191	Histidine kinase
I5154_RS06030	COG4566	intracellular signal transduction
I5154_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS06045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5154_RS06050	COG2271	Major facilitator Superfamily
I5154_RS06095	COG2226	methyltransferase
I5154_RS06105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5154_RS06120	COG0251	oxidation-reduction process
I5154_RS06130	COG0693	protein deglycase activity
I5154_RS06135	COG0492	ferredoxin-NADP+ reductase activity
I5154_RS06140	COG1959	2 iron, 2 sulfur cluster binding
I5154_RS06170	COG0154	amidase activity
I5154_RS06175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5154_RS06180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5154_RS06185	COG4592	Periplasmic binding protein
I5154_RS06190	COG1120	ATPase activity
I5154_RS06200	COG1629	transport
I5154_RS06200	COG4774	siderophore transport
I5154_RS06205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5154_RS06210	COG4991	sh3 domain protein
I5154_RS06215	COG1063	alcohol dehydrogenase
I5154_RS06225	COG0022	dehydrogenase e1 component
I5154_RS06230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5154_RS06235	COG3199	ATP-NAD kinase
I5154_RS06245	COG3284	Transcriptional regulator
I5154_RS06270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS06300	COG2814	Major facilitator Superfamily
I5154_RS06305	COG1846	Transcriptional regulator
I5154_RS06315	COG3278	Belongs to the heme-copper respiratory oxidase family
I5154_RS06320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5154_RS06330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5154_RS06345	COG3971	2-oxopent-4-enoate hydratase activity
I5154_RS06350	COG2271	Major facilitator Superfamily
I5154_RS06360	COG3384	dioxygenase
I5154_RS06365	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS06405	COG1611	Belongs to the LOG family
I5154_RS06450	COG0583	DNA-binding transcription factor activity
I5154_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS06475	COG1063	alcohol dehydrogenase
I5154_RS06480	COG2271	Major facilitator Superfamily
I5154_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS06535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5154_RS06550	COG3121	Chaperone
I5154_RS06555	COG3188	usher protein
I5154_RS06575	COG2197	response regulator
I5154_RS06615	COG0531	amino acid
I5154_RS06635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5154_RS06645	COG3047	cAMP biosynthetic process
I5154_RS06675	COG3118	belongs to the thioredoxin family
I5154_RS06680	COG2264	protein methyltransferase activity
I5154_RS06695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5154_RS06695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5154_RS06720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I5154_RS06725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5154_RS06735	COG3577	Aspartyl protease
I5154_RS06760	COG0142	geranyltranstransferase activity
I5154_RS06770	COG4948	Mandelate Racemase Muconate Lactonizing
I5154_RS06790	COG1131	(ABC) transporter
I5154_RS06795	COG5002	protein histidine kinase activity
I5154_RS06815	COG0745	RESPONSE REGULATOR receiver
I5154_RS06825	COG3228	Belongs to the MtfA family
I5154_RS06830	COG0586	Pfam SNARE associated Golgi protein
I5154_RS06845	COG0456	acetyltransferase
I5154_RS06855	COG4303	Ethanolamine ammonia lyase large subunit
I5154_RS06860	COG0531	amino acid
I5154_RS06870	COG3284	Transcriptional regulator
I5154_RS06875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5154_RS06890	COG0702	epimerase
I5154_RS06910	COG1346	cytolysis
I5154_RS06920	COG0586	Pfam SNARE associated Golgi protein
I5154_RS06960	COG0768	penicillin binding
I5154_RS06965	COG0772	Belongs to the SEDS family
I5154_RS06970	COG2951	lytic endotransglycosylase activity
I5154_RS06980	COG1686	Belongs to the peptidase S11 family
I5154_RS07010	COG2951	lytic endotransglycosylase activity
I5154_RS07045	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5154_RS07055	COG4535	Mg2 and Co2 transporter CorC
I5154_RS07065	COG1702	phosphate starvation-inducible protein PhoH
I5154_RS07095	COG0351	phosphomethylpyrimidine kinase
I5154_RS07100	COG2198	Histidine kinase
I5154_RS07100	COG0784	Response regulator, receiver
I5154_RS07100	COG2205	protein histidine kinase activity
I5154_RS07110	COG1960	acyl-CoA dehydrogenase activity
I5154_RS07120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5154_RS07125	COG0653	protein targeting
I5154_RS07160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5154_RS07170	COG1643	Atp-dependent helicase
I5154_RS07215	COG3416	Protein conserved in bacteria
I5154_RS07225	COG0513	Belongs to the DEAD box helicase family
I5154_RS07235	COG2197	response regulator
I5154_RS07240	COG2199	diguanylate cyclase activity
I5154_RS07240	COG2200	EAL domain
I5154_RS07240	COG2202	Pas domain
I5154_RS07245	COG2205	protein histidine kinase activity
I5154_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS07265	COG1946	Acyl-CoA thioesterase
I5154_RS07285	COG4521	taurine ABC transporter
I5154_RS07295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5154_RS07300	COG2175	clavaminate synthase activity
I5154_RS07305	COG1297	OPT oligopeptide transporter protein
I5154_RS07310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5154_RS07325	COG1271	oxidase subunit
I5154_RS07330	COG1294	oxidase, subunit
I5154_RS07340	COG2207	Transcriptional regulator
I5154_RS07350	COG0183	Belongs to the thiolase family
I5154_RS07355	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS07380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5154_RS07405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5154_RS07415	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5154_RS07420	COG0303	'Molybdopterin
I5154_RS07425	COG0826	peptidase U32
I5154_RS07430	COG0826	peptidase U32
I5154_RS07435	COG3154	lipid carrier protein
I5154_RS07485	COG4772	TonB-dependent receptor
I5154_RS07490	COG3712	iron ion homeostasis
I5154_RS07495	COG1595	DNA-templated transcription, initiation
I5154_RS07505	COG0697	spore germination
I5154_RS07515	COG0583	DNA-binding transcription factor activity
I5154_RS07535	COG1566	PFAM secretion protein HlyD family protein
I5154_RS07585	COG0300	oxidoreductase activity
I5154_RS07590	COG2226	methyltransferase
I5154_RS07605	COG2197	response regulator
I5154_RS07610	COG3850	Histidine kinase
I5154_RS07620	COG2223	nitrite transmembrane transporter activity
I5154_RS07625	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5154_RS07630	COG1140	nitrate reductase beta subunit
I5154_RS07635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5154_RS07640	COG2181	nitrate reductase activity
I5154_RS07645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5154_RS07660	COG4771	TonB-dependent receptor
I5154_RS07665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS07690	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS07765	COG0583	DNA-binding transcription factor activity
I5154_RS07780	COG0640	Transcriptional regulator
I5154_RS07800	COG0490	domain, Protein
I5154_RS07800	COG0471	metal ion transport
I5154_RS07805	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I5154_RS07810	COG4120	Belongs to the binding-protein-dependent transport system permease family
I5154_RS07855	COG0795	lipopolysaccharide-transporting ATPase activity
I5154_RS07860	COG0795	lipopolysaccharide-transporting ATPase activity
I5154_RS07870	COG2200	EAL domain
I5154_RS07890	COG1862	Preprotein translocase
I5154_RS07905	COG3134	Outer membrane lipoprotein
I5154_RS07920	COG1045	serine acetyltransferase
I5154_RS07940	COG0316	Belongs to the HesB IscA family
I5154_RS08010	COG0436	Aminotransferase
I5154_RS08025	COG0667	Aldo Keto reductase
I5154_RS08065	COG0739	heme binding
I5154_RS08075	COG2847	Copper chaperone PCu(A)C
I5154_RS08085	COG1335	isochorismatase
I5154_RS08100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I5154_RS08110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5154_RS08115	COG0583	DNA-binding transcription factor activity
I5154_RS08125	COG0583	DNA-binding transcription factor activity
I5154_RS08165	COG2132	Multicopper oxidase
I5154_RS08170	COG0590	tRNA wobble adenosine to inosine editing
I5154_RS08215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5154_RS08215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5154_RS08220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5154_RS08225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5154_RS08230	COG2188	Transcriptional regulator
I5154_RS08270	COG0477	Major facilitator Superfamily
I5154_RS08275	COG4536	flavin adenine dinucleotide binding
I5154_RS08285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5154_RS08310	COG1607	acyl-coa hydrolase
I5154_RS08330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5154_RS08355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5154_RS08380	COG2255	four-way junction helicase activity
I5154_RS08395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5154_RS08405	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS08450	COG2197	response regulator
I5154_RS08455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5154_RS08475	COG0477	Major facilitator Superfamily
I5154_RS08510	COG3706	GGDEF domain
I5154_RS08510	COG4251	negative regulation of phosphorylation
I5154_RS08510	COG2203	Gaf domain
I5154_RS08510	COG5001	Diguanylate cyclase
I5154_RS08545	COG1073	alpha beta
I5154_RS08545	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I5154_RS08545	COG3064	Membrane
I5154_RS08560	COG2885	chlorophyll binding
I5154_RS08575	COG0789	Transcriptional regulator
I5154_RS08595	COG1214	PFAM Peptidase M22, glycoprotease
I5154_RS08605	COG1801	Protein of unknown function DUF72
I5154_RS08610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5154_RS08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS08680	COG2166	iron-sulfur cluster assembly
I5154_RS08695	COG1280	lysine exporter protein (LysE YggA)
I5154_RS08700	COG1393	Belongs to the ArsC family
I5154_RS08720	COG0025	NhaP-type Na H and K H
I5154_RS08725	COG0436	Aminotransferase
I5154_RS08735	COG0024	Methionine aminopeptidase
I5154_RS08815	COG1115	amino acid carrier protein
I5154_RS08865	COG2391	methyltransferase activity
I5154_RS08870	COG0583	DNA-binding transcription factor activity
I5154_RS08875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I5154_RS08880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I5154_RS08930	COG1546	Belongs to the CinA family
I5154_RS08950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5154_RS08955	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I5154_RS08960	COG3530	Putative quorum-sensing-regulated virulence factor
I5154_RS08975	COG1177	transmembrane transport
I5154_RS08980	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5154_RS08990	COG3148	PFAM DTW domain containing protein
I5154_RS09010	COG0069	glutamate synthase activity
I5154_RS09035	COG0531	amino acid
I5154_RS09040	COG2169	Transcriptional regulator
I5154_RS09040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5154_RS09045	COG0477	Major facilitator Superfamily
I5154_RS09050	COG0583	DNA-binding transcription factor activity
I5154_RS09055	COG1960	acyl-CoA dehydrogenase activity
I5154_RS09060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5154_RS09065	COG1024	Enoyl-CoA hydratase
I5154_RS09070	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5154_RS09075	COG0183	Belongs to the thiolase family
I5154_RS09085	COG0583	DNA-binding transcription factor activity
I5154_RS09120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5154_RS09155	COG2814	Major facilitator Superfamily
I5154_RS09195	COG0583	DNA-binding transcription factor activity
I5154_RS09205	COG0084	hydrolase, TatD family'
I5154_RS09210	COG1609	Transcriptional regulator
I5154_RS09220	COG1105	Belongs to the carbohydrate kinase PfkB family
I5154_RS09225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5154_RS09225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5154_RS09225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5154_RS09335	COG3842	ATPase activity
I5154_RS09355	COG0243	molybdopterin cofactor binding
I5154_RS09360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5154_RS09365	COG2223	nitrite transmembrane transporter activity
I5154_RS09380	COG0450	alkyl hydroperoxide reductase
I5154_RS09410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS09455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5154_RS09460	COG2264	protein methyltransferase activity
I5154_RS09470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5154_RS09540	COG0489	protein tyrosine kinase activity
I5154_RS09585	COG0791	NLP P60 protein
I5154_RS09600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5154_RS09605	COG0668	transmembrane transport
I5154_RS09610	COG0477	Major facilitator Superfamily
I5154_RS09615	COG0513	Belongs to the DEAD box helicase family
I5154_RS09635	COG2205	protein histidine kinase activity
I5154_RS09635	COG5002	protein histidine kinase activity
I5154_RS09635	COG0784	Response regulator, receiver
I5154_RS09640	COG1363	Peptidase, m42
I5154_RS09645	COG0189	ligase activity
I5154_RS09645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5154_RS09650	COG0367	asparagine synthase
I5154_RS09680	COG0183	Belongs to the thiolase family
I5154_RS09700	COG0450	alkyl hydroperoxide reductase
I5154_RS09705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS09710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5154_RS09720	COG0431	NADPH-dependent FMN reductase
I5154_RS09725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS09735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5154_RS09760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5154_RS09785	COG0583	DNA-binding transcription factor activity
I5154_RS09790	COG1380	Effector of murein hydrolase LrgA
I5154_RS09795	COG1346	cytolysis
I5154_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS09820	COG1024	Enoyl-CoA hydratase
I5154_RS09830	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5154_RS09875	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5154_RS09915	COG1629	transport
I5154_RS09970	COG0583	DNA-binding transcription factor activity
I5154_RS10045	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5154_RS10050	COG3639	organic phosphonate transmembrane transporter activity
I5154_RS10055	COG2188	Transcriptional regulator
I5154_RS10060	COG3624	Phosphonate C-P lyase system protein PhnG
I5154_RS10070	COG3626	phosphonate metabolism
I5154_RS10075	COG3627	carbon phosphorus lyase activity
I5154_RS10080	COG4107	phosphonate C-P lyase system protein PhnK
I5154_RS10085	COG4778	phosphonate C-P lyase system protein PhnL
I5154_RS10090	COG3454	Phosphonate metabolism
I5154_RS10100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5154_RS10175	COG1566	PFAM secretion protein HlyD family protein
I5154_RS10185	COG0697	spore germination
I5154_RS10210	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I5154_RS10230	COG0784	Response regulator, receiver
I5154_RS10230	COG0835	chemotaxis
I5154_RS10245	COG0745	RESPONSE REGULATOR receiver
I5154_RS10255	COG0514	ATP-dependent DNA helicase (RecQ)
I5154_RS10260	COG5001	Diguanylate cyclase
I5154_RS10260	COG4251	negative regulation of phosphorylation
I5154_RS10260	COG3706	GGDEF domain
I5154_RS10260	COG2203	Gaf domain
I5154_RS10280	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5154_RS10320	COG2124	cytochrome p450
I5154_RS10325	COG4221	oxidoreductase activity
I5154_RS10370	COG0583	DNA-binding transcription factor activity
I5154_RS10400	COG3639	organic phosphonate transmembrane transporter activity
I5154_RS10410	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5154_RS10415	COG2084	Dehydrogenase
I5154_RS10430	COG0589	response to stress
I5154_RS10470	COG2814	Major facilitator Superfamily
I5154_RS10475	COG2030	dehydratase
I5154_RS10480	COG2267	carboxylic ester hydrolase activity
I5154_RS10485	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS10490	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS10500	COG1643	Atp-dependent helicase
I5154_RS10510	COG0537	adenosine 5'-monophosphoramidase activity
I5154_RS10565	COG1595	DNA-templated transcription, initiation
I5154_RS10635	COG1201	RNA secondary structure unwinding
I5154_RS10640	COG2205	protein histidine kinase activity
I5154_RS10655	COG4772	TonB-dependent receptor
I5154_RS10670	COG2076	Multidrug Resistance protein
I5154_RS10675	COG0385	Bile acid
I5154_RS10725	COG2200	EAL domain
I5154_RS10735	COG0604	alcohol dehydrogenase
I5154_RS10735	COG3321	synthase
I5154_RS10740	COG0560	Phosphoserine phosphatase
I5154_RS10755	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5154_RS10785	COG0564	pseudouridine synthase activity
I5154_RS10795	COG2894	cell division
I5154_RS10805	COG1560	Kdo2-lipid A biosynthetic process
I5154_RS10925	COG2853	Lipoprotein
I5154_RS10945	COG3162	membrane
I5154_RS10950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5154_RS10980	COG1132	(ABC) transporter
I5154_RS10990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5154_RS11015	COG0509	glycine decarboxylation via glycine cleavage system
I5154_RS11045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5154_RS11060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5154_RS11060	COG0438	transferase activity, transferring glycosyl groups
I5154_RS11090	COG1127	ABC transporter
I5154_RS11095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5154_RS11100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5154_RS11105	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5154_RS11110	COG0778	Nitroreductase
I5154_RS11130	COG0745	RESPONSE REGULATOR receiver
I5154_RS11140	COG2350	Protein conserved in bacteria
I5154_RS11150	COG0613	PHP domain protein
I5154_RS11155	COG0009	L-threonylcarbamoyladenylate synthase
I5154_RS11160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I5154_RS11165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5154_RS11215	COG1175	transmembrane transport
I5154_RS11220	COG0395	ABC-type sugar transport system, permease component
I5154_RS11225	COG3842	ATPase activity
I5154_RS11235	COG0676	glucose-6-phosphate 1-epimerase activity
I5154_RS11280	COG0786	glutamate:sodium symporter activity
I5154_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS11310	COG0402	S-adenosylhomocysteine deaminase activity
I5154_RS11340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5154_RS11385	COG1086	Polysaccharide biosynthesis protein
I5154_RS11410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5154_RS11450	COG0583	DNA-binding transcription factor activity
I5154_RS11485	COG0596	Alpha beta hydrolase
I5154_RS11490	COG0800	Aldolase
I5154_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS11525	COG0583	DNA-binding transcription factor activity
I5154_RS11530	COG0251	oxidation-reduction process
I5154_RS11550	COG2226	methyltransferase
I5154_RS11590	COG0285	dihydrofolate synthase activity
I5154_RS11595	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5154_RS11600	COG1286	toxin biosynthetic process
I5154_RS11700	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5154_RS11700	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS11725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5154_RS11735	COG3139	Protein of unknown function (DUF1315)
I5154_RS11745	COG0308	aminopeptidase N
I5154_RS11775	COG0745	RESPONSE REGULATOR receiver
I5154_RS11815	COG0714	Associated with various cellular activities
I5154_RS11830	COG2342	PFAM TM1410 hypothetical-related protein
I5154_RS11855	COG0297	glycogen (starch) synthase activity
I5154_RS11905	COG3130	regulation of translation
I5154_RS11915	COG2027	D-alanyl-D-alanine carboxypeptidase
I5154_RS11920	COG3171	Protein conserved in bacteria
I5154_RS11925	COG2197	response regulator
I5154_RS11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS11930	COG2205	protein histidine kinase activity
I5154_RS11955	COG0004	ammonium transporteR
I5154_RS11965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5154_RS11975	COG0625	glutathione transferase activity
I5154_RS11980	COG1309	transcriptional regulator
I5154_RS12010	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5154_RS12030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5154_RS12035	COG1070	Carbohydrate kinase
I5154_RS12055	COG0741	lytic transglycosylase activity
I5154_RS12060	COG0488	(ABC) transporter
I5154_RS12070	COG0589	response to stress
I5154_RS12145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5154_RS12155	COG1113	amino acid transport
I5154_RS12190	COG1477	protein flavinylation
I5154_RS12205	COG0584	glycerophosphoryl diester phosphodiesterase
I5154_RS12220	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5154_RS12240	COG0658	competence protein
I5154_RS12240	COG2333	competence protein COMEC
I5154_RS12245	COG0811	peptide transport
I5154_RS12250	COG0848	biopolymer transport protein
I5154_RS12270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5154_RS12280	COG1530	ribonuclease E activity
I5154_RS12290	COG0546	phosphoglycolate phosphatase activity
I5154_RS12295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5154_RS12295	COG0616	signal peptide processing
I5154_RS12305	COG1399	metal-binding, possibly nucleic acid-binding protein
I5154_RS12335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5154_RS12345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5154_RS12365	COG0084	hydrolase, TatD family'
I5154_RS12450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5154_RS12465	COG0183	Belongs to the thiolase family
I5154_RS12475	COG2233	PERMEase
I5154_RS12495	COG2814	Major facilitator Superfamily
I5154_RS12500	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS12505	COG1309	transcriptional regulator
I5154_RS12540	COG4160	amino acid transport
I5154_RS12545	COG4215	(ABC) transporter
I5154_RS12550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS12555	COG1473	amidohydrolase
I5154_RS12560	COG0583	DNA-binding transcription factor activity
I5154_RS12565	COG0840	transmembrane signaling receptor activity
I5154_RS12595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5154_RS12605	COG1120	ATPase activity
I5154_RS12635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5154_RS12665	COG3047	cAMP biosynthetic process
I5154_RS12665	COG2885	chlorophyll binding
I5154_RS12670	COG2197	response regulator
I5154_RS12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5154_RS12685	COG1595	DNA-templated transcription, initiation
I5154_RS12700	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS12715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I5154_RS12720	COG1960	acyl-CoA dehydrogenase activity
I5154_RS12725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5154_RS12740	COG1309	transcriptional regulator
I5154_RS12770	COG0583	DNA-binding transcription factor activity
I5154_RS12780	COG0583	DNA-binding transcription factor activity
I5154_RS12790	COG0714	Associated with various cellular activities
I5154_RS12835	COG0084	hydrolase, TatD family'
I5154_RS12840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5154_RS12845	COG2259	Doxx family
I5154_RS12860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5154_RS12875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5154_RS12880	COG4181	ATPase activity
I5154_RS12920	COG1764	response to oxidative stress
I5154_RS12925	COG1846	Transcriptional regulator
I5154_RS12930	COG0583	DNA-binding transcription factor activity
I5154_RS12940	COG0583	DNA-binding transcription factor activity
I5154_RS12950	COG3214	Protein conserved in bacteria
I5154_RS12955	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I5154_RS12965	COG1024	Enoyl-CoA hydratase
I5154_RS12975	COG3384	dioxygenase
I5154_RS13015	COG2866	Carboxypeptidase
I5154_RS13030	COG0436	Aminotransferase
I5154_RS13040	COG0386	Belongs to the glutathione peroxidase family
I5154_RS13045	COG1846	Transcriptional regulator
I5154_RS13050	COG0784	Response regulator, receiver
I5154_RS13050	COG5002	protein histidine kinase activity
I5154_RS13050	COG2205	protein histidine kinase activity
I5154_RS13055	COG2255	four-way junction helicase activity
I5154_RS13060	COG1956	GAF domain-containing protein
I5154_RS13065	COG0625	glutathione transferase activity
I5154_RS13105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS13130	COG1396	sequence-specific DNA binding
I5154_RS13135	COG0583	DNA-binding transcription factor activity
I5154_RS13175	COG2132	Multicopper oxidase
I5154_RS13180	COG0745	RESPONSE REGULATOR receiver
I5154_RS13185	COG5002	protein histidine kinase activity
I5154_RS13205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5154_RS13210	COG0789	Transcriptional regulator
I5154_RS13215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5154_RS13220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I5154_RS13225	COG1309	transcriptional regulator
I5154_RS13230	COG0300	oxidoreductase activity
I5154_RS13250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5154_RS13270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I5154_RS13275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5154_RS13285	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5154_RS13300	COG2217	Heavy metal translocating P-type atpase
I5154_RS13305	COG2326	polyphosphate kinase activity
I5154_RS13340	COG0789	Transcriptional regulator
I5154_RS13405	COG2003	Belongs to the UPF0758 family
I5154_RS13460	COG3311	Transcriptional regulator
I5154_RS13465	COG1569	PIN domain
I5154_RS13535	COG0640	Transcriptional regulator
I5154_RS13545	COG0798	PFAM Bile acid sodium symporter
I5154_RS13550	COG1393	Belongs to the ArsC family
I5154_RS13555	COG0431	NADPH-dependent FMN reductase
I5154_RS13640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5154_RS13650	COG0789	Transcriptional regulator
I5154_RS13665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5154_RS13670	COG0629	single-stranded DNA binding
I5154_RS13795	COG0625	glutathione transferase activity
I5154_RS13800	COG1131	(ABC) transporter
I5154_RS13805	COG0842	Transport permease protein
I5154_RS13850	COG2188	Transcriptional regulator
I5154_RS13860	COG2853	Lipoprotein
I5154_RS13870	COG0745	RESPONSE REGULATOR receiver
I5154_RS13890	COG1335	isochorismatase
I5154_RS13930	COG0840	transmembrane signaling receptor activity
I5154_RS13945	COG3655	Transcriptional regulator
I5154_RS13985	COG2116	formate transmembrane transporter activity
I5154_RS13990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS14025	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I5154_RS14040	COG1051	belongs to the nudix hydrolase family
I5154_RS14050	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5154_RS14050	COG1024	Enoyl-CoA hydratase
I5154_RS14060	COG2837	iron assimilation
I5154_RS14145	COG1238	metal cluster binding
I5154_RS14155	COG1295	ribonuclease BN
I5154_RS14180	COG4974	Belongs to the 'phage' integrase family
I5154_RS14200	COG3568	Endonuclease Exonuclease Phosphatase
I5154_RS14200	COG1555	photosystem II stabilization
I5154_RS14210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5154_RS14225	COG1358	cellular component organization or biogenesis
I5154_RS14285	COG1929	Belongs to the glycerate kinase type-1 family
I5154_RS14290	COG4644	lycopene metabolic process
I5154_RS14445	COG1061	Type III restriction enzyme res subunit
I5154_RS14475	COG0024	Methionine aminopeptidase
I5154_RS14550	COG0514	ATP-dependent DNA helicase (RecQ)
I5154_RS14560	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5154_RS14575	COG0210	DNA helicase
I5154_RS14585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5154_RS14640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I5154_RS14640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I5154_RS14650	COG0542	response to heat
I5154_RS14695	COG0789	Transcriptional regulator
I5154_RS14705	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5154_RS14705	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS14710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I5154_RS14715	COG0243	molybdopterin cofactor binding
I5154_RS14735	COG1280	lysine exporter protein (LysE YggA)
I5154_RS14750	COG0542	response to heat
I5154_RS14820	COG1607	acyl-coa hydrolase
I5154_RS14825	COG1959	2 iron, 2 sulfur cluster binding
I5154_RS14840	COG2819	hydrolase of the alpha beta superfamily
I5154_RS14875	COG1802	Transcriptional regulator
I5154_RS14880	COG3938	Belongs to the proline racemase family
I5154_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS14890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS14895	COG3938	Belongs to the proline racemase family
I5154_RS14900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5154_RS14905	COG0765	amino acid transport
I5154_RS14910	COG0765	amino acid transport
I5154_RS14915	COG1126	abc transporter atp-binding protein
I5154_RS14920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS14935	COG0583	DNA-binding transcription factor activity
I5154_RS14945	COG4106	trans-aconitate 2-methyltransferase activity
I5154_RS14955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5154_RS14960	COG1459	type II secretion system
I5154_RS15010	COG0720	synthase
I5154_RS15015	COG3604	Transcriptional regulator
I5154_RS15075	COG0840	transmembrane signaling receptor activity
I5154_RS15080	COG2056	Na+-H+ antiporter family
I5154_RS15095	COG2226	methyltransferase
I5154_RS15190	COG2153	protein acetylation
I5154_RS15195	COG2850	peptidyl-arginine hydroxylation
I5154_RS15235	COG1278	Cold shock
I5154_RS15245	COG0542	response to heat
I5154_RS15250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5154_RS15265	COG0492	ferredoxin-NADP+ reductase activity
I5154_RS15280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5154_RS15295	COG0435	Glutathione S-transferase
I5154_RS15300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5154_RS15305	COG2920	part of a sulfur-relay system
I5154_RS15345	COG0583	DNA-binding transcription factor activity
I5154_RS15350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5154_RS15355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS15365	COG1960	acyl-CoA dehydrogenase activity
I5154_RS15370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS15380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS15395	COG2197	response regulator
I5154_RS15400	COG4771	TonB-dependent receptor
I5154_RS15440	COG0582	viral genome integration into host DNA
I5154_RS15445	COG2837	iron assimilation
I5154_RS15460	COG0583	DNA-binding transcription factor activity
I5154_RS15470	COG0583	DNA-binding transcription factor activity
I5154_RS15525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I5154_RS15530	COG1252	NADH dehydrogenase
I5154_RS15535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5154_RS15595	COG2003	Belongs to the UPF0758 family
I5154_RS15780	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5154_RS15790	COG0629	single-stranded DNA binding
I5154_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS15850	COG2205	protein histidine kinase activity
I5154_RS15870	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5154_RS15885	COG1522	sequence-specific DNA binding
I5154_RS15915	COG4191	Histidine kinase
I5154_RS15940	COG4251	negative regulation of phosphorylation
I5154_RS15940	COG5001	Diguanylate cyclase
I5154_RS15940	COG2203	Gaf domain
I5154_RS15940	COG3706	GGDEF domain
I5154_RS15965	COG0659	secondary active sulfate transmembrane transporter activity
I5154_RS16005	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS16015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5154_RS16025	COG0183	Belongs to the thiolase family
I5154_RS16030	COG1960	acyl-CoA dehydrogenase activity
I5154_RS16080	COG0729	surface antigen
I5154_RS16090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5154_RS16095	COG2267	carboxylic ester hydrolase activity
I5154_RS16100	COG0671	phosphoesterase, PA-phosphatase related
I5154_RS16100	COG2453	phosphatase
I5154_RS16115	COG4589	Belongs to the CDS family
I5154_RS16120	COG0667	Aldo Keto reductase
I5154_RS16130	COG1115	amino acid carrier protein
I5154_RS16140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5154_RS16160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS16165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS16170	COG1538	Outer membrane efflux protein
I5154_RS16230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5154_RS16230	COG0543	2 iron, 2 sulfur cluster binding
I5154_RS16235	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5154_RS16240	COG4638	Rieske (2fe-2S)
I5154_RS16255	COG4948	Mandelate Racemase Muconate Lactonizing
I5154_RS16265	COG3485	protocatechuate 3,4-dioxygenase
I5154_RS16300	COG2807	transmembrane transport
I5154_RS16305	COG0590	tRNA wobble adenosine to inosine editing
I5154_RS16320	COG2318	DinB family
I5154_RS16380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5154_RS16385	COG2863	cytochrome
I5154_RS16390	COG3258	Cytochrome c
I5154_RS16395	COG0642	Histidine kinase
I5154_RS16430	COG0625	glutathione transferase activity
I5154_RS16435	COG2814	Major facilitator Superfamily
I5154_RS16450	COG0583	DNA-binding transcription factor activity
I5154_RS16455	COG1595	DNA-templated transcription, initiation
I5154_RS16460	COG3712	iron ion homeostasis
I5154_RS16485	COG3210	domain, Protein
I5154_RS16550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5154_RS16560	COG2382	esterase
I5154_RS16580	COG0583	DNA-binding transcription factor activity
I5154_RS16600	COG1760	l-serine dehydratase
I5154_RS16605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5154_RS16640	COG2217	Heavy metal translocating P-type atpase
I5154_RS16655	COG0583	DNA-binding transcription factor activity
I5154_RS16670	COG1566	PFAM secretion protein HlyD family protein
I5154_RS16730	COG1335	isochorismatase
I5154_RS16740	COG0583	DNA-binding transcription factor activity
I5154_RS16780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5154_RS16785	COG1121	(ABC) transporter
I5154_RS16825	COG0657	acetylesterase activity
I5154_RS16830	COG4774	siderophore transport
I5154_RS16875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS16900	COG0735	belongs to the Fur family
I5154_RS16910	COG1304	FMN binding
I5154_RS16940	COG4566	intracellular signal transduction
I5154_RS17030	COG3829	transcription factor binding
I5154_RS17055	COG3829	transcription factor binding
I5154_RS17060	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5154_RS17065	COG0584	glycerophosphoryl diester phosphodiesterase
I5154_RS17070	COG2011	ABC-type metal ion transport system permease component
I5154_RS17080	COG1464	Belongs to the NlpA lipoprotein family
I5154_RS17105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5154_RS17110	COG1070	Carbohydrate kinase
I5154_RS17115	COG0246	Mannitol dehydrogenase
I5154_RS17130	COG1175	transmembrane transport
I5154_RS17145	COG1917	Cupin 2, conserved barrel domain protein
I5154_RS17145	COG4977	sequence-specific DNA binding
I5154_RS17160	COG1116	anion transmembrane transporter activity
I5154_RS17165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS17170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5154_RS17190	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS17205	COG3265	gluconokinase activity
I5154_RS17210	COG1609	Transcriptional regulator
I5154_RS17220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS17225	COG0583	DNA-binding transcription factor activity
I5154_RS17250	COG1396	sequence-specific DNA binding
I5154_RS17260	COG2175	clavaminate synthase activity
I5154_RS17270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5154_RS17275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5154_RS17300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5154_RS17300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5154_RS17310	COG3469	chitinase activity
I5154_RS17315	COG2188	Transcriptional regulator
I5154_RS17320	COG1053	succinate dehydrogenase
I5154_RS17355	COG4772	TonB-dependent receptor
I5154_RS17400	COG0431	NADPH-dependent FMN reductase
I5154_RS17405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5154_RS17415	COG0640	Transcriptional regulator
I5154_RS17420	COG2207	Transcriptional regulator
I5154_RS17425	COG1064	alcohol dehydrogenase
I5154_RS17450	COG1309	transcriptional regulator
I5154_RS17460	COG2329	Antibiotic biosynthesis monooxygenase
I5154_RS17495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5154_RS17505	COG1609	Transcriptional regulator
I5154_RS17535	COG0252	asparaginase activity
I5154_RS17540	COG1115	amino acid carrier protein
I5154_RS17585	COG1053	succinate dehydrogenase
I5154_RS17595	COG0728	peptidoglycan biosynthetic process
I5154_RS17655	COG2258	MOSC domain
I5154_RS17725	COG2508	Transcriptional regulator
I5154_RS17750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS17755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS17760	COG4221	oxidoreductase activity
I5154_RS17770	COG2020	methyltransferase activity
I5154_RS17775	COG3634	alkyl hydroperoxide reductase activity
I5154_RS17780	COG1309	transcriptional regulator
I5154_RS17795	COG0384	phenazine biosynthesis protein PhzF
I5154_RS17825	COG5006	permease, DMT superfamily
I5154_RS17840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5154_RS17855	COG3795	YCII-related domain
I5154_RS17865	COG2814	Major facilitator Superfamily
I5154_RS17870	COG4941	Belongs to the sigma-70 factor family
I5154_RS17880	COG3795	YCII-related domain
I5154_RS17890	COG2197	response regulator
I5154_RS17895	COG1982	Orn Lys Arg decarboxylase major
I5154_RS17900	COG0189	ligase activity
I5154_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS17920	COG0765	amino acid transport
I5154_RS17925	COG0765	amino acid transport
I5154_RS17930	COG1126	abc transporter atp-binding protein
I5154_RS17955	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS17970	COG1253	flavin adenine dinucleotide binding
I5154_RS17975	COG0300	oxidoreductase activity
I5154_RS17985	COG0583	DNA-binding transcription factor activity
I5154_RS17990	COG3591	Belongs to the peptidase S1B family
I5154_RS17990	COG1864	DNA RNA non-specific endonuclease
I5154_RS17995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5154_RS18000	COG4319	ketosteroid isomerase
I5154_RS18015	COG4774	siderophore transport
I5154_RS18060	COG2814	Major facilitator Superfamily
I5154_RS18080	COG0583	DNA-binding transcription factor activity
I5154_RS18090	COG0121	glutamine amidotransferase
I5154_RS18120	COG3712	iron ion homeostasis
I5154_RS18125	COG1595	DNA-templated transcription, initiation
I5154_RS18140	COG1230	cation diffusion facilitator family transporter
I5154_RS18145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5154_RS18205	COG1960	acyl-CoA dehydrogenase activity
I5154_RS18225	COG0406	alpha-ribazole phosphatase activity
I5154_RS18255	COG0778	Nitroreductase
I5154_RS18270	COG4206	TonB-dependent receptor
I5154_RS18280	COG1802	Transcriptional regulator
I5154_RS18290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS18325	COG0477	Major facilitator Superfamily
I5154_RS18345	COG0765	amino acid transport
I5154_RS18355	COG1126	abc transporter atp-binding protein
I5154_RS18365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5154_RS18370	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS18420	COG0784	Response regulator, receiver
I5154_RS18420	COG4191	Histidine kinase
I5154_RS18475	COG1289	transmembrane transporter activity
I5154_RS18490	COG2207	Transcriptional regulator
I5154_RS18510	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5154_RS18515	COG2957	Belongs to the agmatine deiminase family
I5154_RS18530	COG2957	Belongs to the agmatine deiminase family
I5154_RS18535	COG0583	DNA-binding transcription factor activity
I5154_RS18550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5154_RS18575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5154_RS18585	COG0318	PFAM AMP-dependent synthetase and ligase
I5154_RS18590	COG0367	asparagine synthase
I5154_RS18600	COG2211	Major facilitator Superfamily
I5154_RS18650	COG1335	isochorismatase
I5154_RS18655	COG0583	DNA-binding transcription factor activity
I5154_RS18665	COG0791	NLP P60 protein
I5154_RS18670	COG0791	NLP P60 protein
I5154_RS18680	COG3829	transcription factor binding
I5154_RS18695	COG2818	Glycosylase
I5154_RS18720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5154_RS18725	COG1960	acyl-CoA dehydrogenase activity
I5154_RS18735	COG0625	glutathione transferase activity
I5154_RS18755	COG5001	Diguanylate cyclase
I5154_RS18755	COG3447	MASE1 domain protein
I5154_RS18755	COG5002	protein histidine kinase activity
I5154_RS18775	COG4459	periplasmic nitrate reductase
I5154_RS18780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5154_RS18780	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5154_RS18785	COG3062	negative regulation of establishment of protein localization
I5154_RS18795	COG3043	anaerobic respiration
I5154_RS18800	COG3005	denitrification pathway
I5154_RS18805	COG2951	lytic endotransglycosylase activity
I5154_RS18810	COG0861	Integral membrane protein TerC family
I5154_RS18815	COG0753	catalase activity
I5154_RS18840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5154_RS18855	COG2226	methyltransferase
I5154_RS18870	COG2205	protein histidine kinase activity
I5154_RS18875	COG0745	RESPONSE REGULATOR receiver
I5154_RS18880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5154_RS18880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5154_RS18885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5154_RS18890	COG1943	Transposase
I5154_RS18925	COG0531	amino acid
I5154_RS18955	COG0583	DNA-binding transcription factor activity
I5154_RS18960	COG3257	ureidoglycine aminohydrolase activity
I5154_RS18975	COG0604	alcohol dehydrogenase
I5154_RS18975	COG3321	synthase
I5154_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS18980	COG2197	response regulator
I5154_RS19020	COG0583	DNA-binding transcription factor activity
I5154_RS19025	COG0667	Aldo Keto reductase
I5154_RS19050	COG0242	peptide deformylase activity
I5154_RS19060	COG2199	diguanylate cyclase activity
I5154_RS19065	COG2885	chlorophyll binding
I5154_RS19095	COG1132	(ABC) transporter
I5154_RS19105	COG4628	conserved protein (DUF2132)
I5154_RS19110	COG2133	pyrroloquinoline quinone binding
I5154_RS19125	COG2207	Transcriptional regulator
I5154_RS19130	COG0477	Major facilitator Superfamily
I5154_RS19145	COG2882	bacterial-type flagellum organization
I5154_RS19200	COG1516	flagellar protein fliS
I5154_RS19205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5154_RS19215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5154_RS19220	COG1216	Glycosyl transferase, family 2
I5154_RS19220	COG0438	transferase activity, transferring glycosyl groups
I5154_RS19245	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS19250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5154_RS19295	COG4787	bacterial-type flagellum-dependent cell motility
I5154_RS19305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I5154_RS19315	COG1815	bacterial-type flagellum-dependent cell motility
I5154_RS19360	COG0326	Molecular chaperone. Has ATPase activity
I5154_RS19375	COG3189	MarR family transcriptional regulator
I5154_RS19395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5154_RS19410	COG2212	antiporter activity
I5154_RS19415	COG1863	multisubunit Na H antiporter MnhE subunit
I5154_RS19420	COG0651	ATP synthesis coupled electron transport
I5154_RS19425	COG1006	Multisubunit Na H antiporter MnhC subunit
I5154_RS19430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5154_RS19430	COG2111	Na H antiporter
I5154_RS19435	COG3133	Outer membrane lipoprotein
I5154_RS19445	COG1929	Belongs to the glycerate kinase type-1 family
I5154_RS19450	COG2610	gluconate transmembrane transporter activity
I5154_RS19455	COG3835	regulator
I5154_RS19465	COG2885	chlorophyll binding
I5154_RS19480	COG1199	ATP-dependent helicase activity
I5154_RS19520	COG2860	membrane
I5154_RS19535	COG0653	protein targeting
I5154_RS19540	COG0625	glutathione transferase activity
I5154_RS19565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS19570	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS19600	COG1960	acyl-CoA dehydrogenase activity
I5154_RS19605	COG1024	Enoyl-CoA hydratase
I5154_RS19610	COG1960	acyl-CoA dehydrogenase activity
I5154_RS19620	COG2814	Major facilitator Superfamily
I5154_RS19625	COG2030	dehydratase
I5154_RS19635	COG0183	Belongs to the thiolase family
I5154_RS19665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5154_RS19670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5154_RS19685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5154_RS19695	COG0425	Belongs to the sulfur carrier protein TusA family
I5154_RS19750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5154_RS19755	COG3188	usher protein
I5154_RS19775	COG1051	belongs to the nudix hydrolase family
I5154_RS19840	COG1289	transmembrane transporter activity
I5154_RS19855	COG0583	DNA-binding transcription factor activity
I5154_RS19865	COG1566	PFAM secretion protein HlyD family protein
I5154_RS19875	COG1335	isochorismatase
I5154_RS19945	COG1074	ATP-dependent DNA helicase activity
I5154_RS20045	COG4644	lycopene metabolic process
I5154_RS20080	COG3609	addiction module antidote protein, CC2985 family
I5154_RS20145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5154_RS20160	COG0602	queuosine metabolic process
I5154_RS20165	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5154_RS20195	COG0824	Thioesterase
I5154_RS20225	COG0783	Belongs to the Dps family
I5154_RS20270	COG3118	belongs to the thioredoxin family
I5154_RS20305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5154_RS20320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5154_RS20360	COG3122	Protein conserved in bacteria
I5154_RS20370	COG3956	TIGRFAM MazG family protein
I5154_RS20375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5154_RS20405	COG2205	protein histidine kinase activity
I5154_RS20405	COG5002	protein histidine kinase activity
I5154_RS20405	COG0784	Response regulator, receiver
I5154_RS20410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5154_RS20460	COG3038	cytochrome b561
I5154_RS20475	COG4807	Protein conserved in bacteria
I5154_RS20485	COG2239	Acts as a magnesium transporter
I5154_RS20555	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5154_RS20650	COG2301	Belongs to the HpcH HpaI aldolase family
I5154_RS20660	COG2079	MmgE PrpD family protein
I5154_RS20670	COG1960	acyl-CoA dehydrogenase activity
I5154_RS20675	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I5154_RS20680	COG0583	DNA-binding transcription factor activity
I5154_RS20685	COG0583	DNA-binding transcription factor activity
I5154_RS20735	COG1113	amino acid transport
I5154_RS20755	COG3321	synthase
I5154_RS20755	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS20755	COG0604	alcohol dehydrogenase
I5154_RS20765	COG5002	protein histidine kinase activity
I5154_RS20765	COG5001	Diguanylate cyclase
I5154_RS20785	COG0271	Belongs to the BolA IbaG family
I5154_RS20825	COG0492	ferredoxin-NADP+ reductase activity
I5154_RS20830	COG0450	alkyl hydroperoxide reductase
I5154_RS20865	COG1307	EDD domain protein, DegV family
I5154_RS20875	COG1309	transcriptional regulator
I5154_RS20880	COG0386	Belongs to the glutathione peroxidase family
I5154_RS20905	COG0204	Acyl-transferase
I5154_RS20910	COG2885	chlorophyll binding
I5154_RS20915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5154_RS20930	COG2267	carboxylic ester hydrolase activity
I5154_RS21055	COG4695	Portal protein
I5154_RS21085	COG3179	chitinase
I5154_RS21095	COG3646	Phage regulatory protein
I5154_RS21110	COG0305	Participates in initiation and elongation during chromosome replication
I5154_RS21240	COG0582	viral genome integration into host DNA
I5154_RS21280	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I5154_RS21315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5154_RS21330	COG0546	phosphoglycolate phosphatase activity
I5154_RS21345	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5154_RS21360	COG0656	L-ascorbic acid biosynthetic process
I5154_RS21385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5154_RS21395	COG1802	Transcriptional regulator
I5154_RS21405	COG0372	Belongs to the citrate synthase family
I5154_RS21420	COG2079	MmgE PrpD family protein
I5154_RS21435	COG1113	amino acid transport
I5154_RS21440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5154_RS21470	COG0583	DNA-binding transcription factor activity
I5154_RS21475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5154_RS21485	COG4206	TonB-dependent receptor
I5154_RS21495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5154_RS21560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5154_RS21640	COG3180	Ammonia monooxygenase
I5154_RS21650	COG2720	vancomycin resistance protein
I5154_RS21665	COG1960	acyl-CoA dehydrogenase activity
I5154_RS21670	COG1024	Enoyl-CoA hydratase
I5154_RS21695	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5154_RS21765	COG0582	viral genome integration into host DNA
I5154_RS21815	COG0629	single-stranded DNA binding
I5154_RS21820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5154_RS21980	COG2003	Belongs to the UPF0758 family
I5154_RS22120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5154_RS22245	COG0420	3'-5' exonuclease activity
I5154_RS22255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5154_RS22260	COG1074	ATP-dependent DNA helicase activity
I5154_RS22265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5154_RS22270	COG0095	Lipoate-protein ligase
I5154_RS22275	COG0697	spore germination
I5154_RS22290	COG0840	transmembrane signaling receptor activity
I5154_RS22300	COG0306	phosphate transporter
I5154_RS22360	COG4964	Belongs to the GSP D family
I5154_RS22380	COG0433	COG0433 Predicted ATPase
I5154_RS22425	COG2925	Exonuclease
I5154_RS22455	COG0714	Associated with various cellular activities
I5154_RS22485	COG0589	response to stress
I5154_RS22495	COG1024	Enoyl-CoA hydratase
I5154_RS22505	COG3706	GGDEF domain
I5154_RS22525	COG0693	protein deglycase activity
I5154_RS22540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5154_RS22555	COG0154	amidase activity
I5154_RS22565	COG1473	amidohydrolase
I5154_RS22580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5154_RS22585	COG0426	domain, Protein
I5154_RS22585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5154_RS22605	COG0589	response to stress
I5154_RS22620	COG2814	Major facilitator Superfamily
I5154_RS22625	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS22640	COG1918	ferrous iron import across plasma membrane
I5154_RS22655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5154_RS22695	COG1704	LemA family
I5154_RS22720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS22725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS22740	COG3642	lipopolysaccharide core region biosynthetic process
I5154_RS22750	COG2205	protein histidine kinase activity
I5154_RS22755	COG0745	RESPONSE REGULATOR receiver
I5154_RS22790	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5154_RS22800	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS22825	COG0668	transmembrane transport
I5154_RS22835	COG0745	RESPONSE REGULATOR receiver
I5154_RS22850	COG2096	Adenosyltransferase
I5154_RS22855	COG0494	nUDIX hydrolase
I5154_RS22875	COG1196	nuclear chromosome segregation
I5154_RS22875	COG0739	heme binding
I5154_RS22875	COG0741	lytic transglycosylase activity
I5154_RS22920	COG0772	Belongs to the SEDS family
I5154_RS22935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5154_RS22975	COG3107	peptidoglycan biosynthetic process
I5154_RS22990	COG2823	Periplasmic or secreted lipoprotein
I5154_RS22995	COG2969	positive regulation of protein catabolic process
I5154_RS23000	COG0625	glutathione transferase activity
I5154_RS23005	COG2857	Cytochrome c1
I5154_RS23010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5154_RS23015	COG0723	plastoquinol--plastocyanin reductase activity
I5154_RS23030	COG0667	Aldo Keto reductase
I5154_RS23035	COG1960	acyl-CoA dehydrogenase activity
I5154_RS23050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5154_RS23060	COG2945	thiolester hydrolase activity
I5154_RS23080	COG2951	lytic endotransglycosylase activity
I5154_RS23090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5154_RS23130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5154_RS23135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5154_RS23140	COG1127	ABC transporter
I5154_RS23150	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5154_RS23165	COG1137	ATPase activity
I5154_RS23220	COG0312	modulator of DNA gyrase
I5154_RS23230	COG0312	modulator of DNA gyrase
I5154_RS23235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5154_RS23245	COG1530	ribonuclease E activity
I5154_RS23260	COG1792	Involved in formation and maintenance of cell shape
I5154_RS23265	COG1077	Cell shape determining protein MreB Mrl
I5154_RS23285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5154_RS23290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5154_RS23295	COG4676	Protein conserved in bacteria
I5154_RS23300	COG5445	Predicted secreted protein (DUF2300)
I5154_RS23315	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I5154_RS23320	COG4676	Protein conserved in bacteria
I5154_RS23325	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I5154_RS23340	COG0747	negative chemotaxis
I5154_RS23345	COG0747	negative chemotaxis
I5154_RS23360	COG0747	negative chemotaxis
I5154_RS23370	COG0747	negative chemotaxis
I5154_RS23375	COG0601	transmembrane transport
I5154_RS23380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5154_RS23385	COG0444	Belongs to the ABC transporter superfamily
I5154_RS23390	COG4608	Belongs to the ABC transporter superfamily
I5154_RS23405	COG1984	allophanate hydrolase subunit 2
I5154_RS23430	COG4774	siderophore transport
I5154_RS23445	COG2194	sulfuric ester hydrolase activity
I5154_RS23455	COG0019	diaminopimelate decarboxylase activity
I5154_RS23555	COG1252	NADH dehydrogenase
I5154_RS23560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5154_RS23565	COG2831	hemolysin activation secretion protein
I5154_RS23635	COG4969	Belongs to the N-Me-Phe pilin family
I5154_RS23675	COG1047	Peptidyl-prolyl cis-trans
I5154_RS23690	COG0196	riboflavin kinase activity
I5154_RS23705	COG3045	CreA protein
I5154_RS23730	COG0142	geranyltranstransferase activity
I5154_RS23745	COG0545	Peptidyl-prolyl cis-trans isomerase
I5154_RS23765	COG1067	ATP-dependent peptidase activity
I5154_RS23800	COG4650	regulator
I5154_RS23815	COG1690	Belongs to the RtcB family
I5154_RS23820	COG3541	Predicted nucleotidyltransferase
I5154_RS23840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5154_RS23865	COG1136	(ABC) transporter
I5154_RS23865	COG0577	efflux transmembrane transporter activity
I5154_RS23870	COG0577	efflux transmembrane transporter activity
I5154_RS23870	COG1136	(ABC) transporter
I5154_RS23875	COG0488	(ABC) transporter
I5154_RS23895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS23900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS23925	COG0523	cobalamin synthesis protein
I5154_RS23930	COG2879	small protein
I5154_RS23935	COG1966	Carbon starvation protein
I5154_RS24005	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5154_RS24005	COG3608	succinylglutamate desuccinylase aspartoacylase
I5154_RS24010	COG2010	Cytochrome c
I5154_RS24045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5154_RS24055	COG0833	amino acid
I5154_RS24060	COG2119	membrane
I5154_RS24075	COG0501	Belongs to the peptidase M48B family
I5154_RS24080	COG0840	transmembrane signaling receptor activity
I5154_RS24085	COG2135	peptidase activity
I5154_RS24090	COG1285	pathogenesis
I5154_RS24150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I5154_RS24205	COG1090	epimerase
I5154_RS24210	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I5154_RS24220	COG0789	Transcriptional regulator
I5154_RS24240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5154_RS24295	COG0012	GTP binding
I5154_RS24300	COG0582	viral genome integration into host DNA
I5154_RS24310	COG1205	dead DEAH box helicase
I5154_RS24310	COG1111	helicase
I5154_RS24315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5154_RS24360	COG3549	Plasmid maintenance system killer
I5154_RS24370	COG0288	reversible hydration of carbon dioxide
I5154_RS24380	COG0456	acetyltransferase
I5154_RS24425	COG1840	ABC-type Fe3 transport system, periplasmic component
I5154_RS24430	COG1178	ABC-type Fe3 transport system permease component
I5154_RS24435	COG3008	intermembrane lipid transfer
I5154_RS24440	COG2995	paraquat-inducible protein a
I5154_RS24445	COG2995	paraquat-inducible protein a
I5154_RS24485	COG1183	phosphatidylcholine synthase activity
I5154_RS24500	COG0028	Belongs to the TPP enzyme family
I5154_RS24515	COG3098	single-species biofilm formation
I5154_RS24525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5154_RS24560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5154_RS24565	COG4558	Periplasmic binding protein
I5154_RS24570	COG3720	iron ion transport
I5154_RS24575	COG4771	TonB-dependent receptor
I5154_RS24600	COG0436	Aminotransferase
I5154_RS24620	COG2252	PERMEase
I5154_RS24635	COG0436	Aminotransferase
I5154_RS24640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5154_RS24655	COG4191	Histidine kinase
I5154_RS24755	COG0195	Participates in both transcription termination and antitermination
I5154_RS24790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5154_RS24855	COG0497	DNA recombination
I5154_RS24885	COG2186	Transcriptional regulator
I5154_RS24890	COG1620	l-lactate permease
I5154_RS24940	COG0697	spore germination
I5154_RS24960	COG0697	spore germination
I5154_RS24965	COG1522	sequence-specific DNA binding
I5154_RS24975	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS24995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5154_RS25025	COG0509	glycine decarboxylation via glycine cleavage system
I5154_RS25065	COG0531	amino acid
I5154_RS25080	COG3276	selenocysteine insertion sequence binding
I5154_RS25095	COG2864	formate dehydrogenase
I5154_RS25100	COG0437	4 iron, 4 sulfur cluster binding
I5154_RS25110	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I5154_RS25115	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5154_RS25115	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS25140	COG0463	Glycosyl transferase, family 2
I5154_RS25150	COG0534	Mate efflux family protein
I5154_RS25160	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5154_RS25185	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5154_RS25210	COG4221	oxidoreductase activity
I5154_RS25215	COG1272	protein, Hemolysin III
I5154_RS25250	COG0023	Translation Initiation Factor
I5154_RS25335	COG2095	MarC family integral membrane protein
I5154_RS25340	COG0683	leucine binding
I5154_RS25355	COG0411	ABC transporter
I5154_RS25400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5154_RS25420	COG0443	Heat shock 70 kDa protein
I5154_RS25445	COG0789	Transcriptional regulator
I5154_RS25450	COG2982	Protein involved in outer membrane biogenesis
I5154_RS25455	COG2193	ferroxidase activity
I5154_RS25465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5154_RS25470	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I5154_RS25530	COG3712	iron ion homeostasis
I5154_RS25535	COG1595	DNA-templated transcription, initiation
I5154_RS25555	COG2814	Major facilitator Superfamily
I5154_RS25565	COG0583	DNA-binding transcription factor activity
I5154_RS25590	COG4221	oxidoreductase activity
I5154_RS25595	COG2423	ornithine cyclodeaminase activity
I5154_RS25625	COG0583	DNA-binding transcription factor activity
I5154_RS25640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5154_RS25680	COG0668	transmembrane transport
I5154_RS25700	COG3300	MHYT domain
I5154_RS25700	COG5001	Diguanylate cyclase
I5154_RS25715	COG0305	Participates in initiation and elongation during chromosome replication
I5154_RS25745	COG0557	exoribonuclease II activity
I5154_RS25775	COG0330	HflC and HflK could
I5154_RS25780	COG0330	HflC and HflK could
I5154_RS25785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5154_RS25805	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5154_RS25810	COG0802	atpase or kinase
I5154_RS25815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5154_RS25815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5154_RS25865	COG5001	Diguanylate cyclase
I5154_RS25865	COG3300	MHYT domain
I5154_RS25870	COG3830	Belongs to the UPF0237 family
I5154_RS25870	COG0560	Phosphoserine phosphatase
I5154_RS25880	COG1988	membrane-bound metal-dependent
I5154_RS25895	COG3577	Aspartyl protease
I5154_RS25910	COG3150	esterase
I5154_RS25915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5154_RS25925	COG0494	nUDIX hydrolase
I5154_RS25940	COG1538	Outer membrane efflux protein
I5154_RS25945	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5154_RS25965	COG1960	acyl-CoA dehydrogenase activity
I5154_RS25970	COG1024	Enoyl-CoA hydratase
I5154_RS25975	COG0833	amino acid
I5154_RS26005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5154_RS26005	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS26015	COG1519	Transferase
I5154_RS26020	COG0583	DNA-binding transcription factor activity
I5154_RS26035	COG0667	Aldo Keto reductase
I5154_RS26045	COG1960	acyl-CoA dehydrogenase activity
I5154_RS26050	COG1960	acyl-CoA dehydrogenase activity
I5154_RS26075	COG1215	transferase activity, transferring glycosyl groups
I5154_RS26095	COG0438	transferase activity, transferring glycosyl groups
I5154_RS26100	COG2192	nodulation
I5154_RS26125	COG0438	transferase activity, transferring glycosyl groups
I5154_RS26130	COG0859	PFAM glycosyl transferase family 9
I5154_RS26135	COG0859	PFAM glycosyl transferase family 9
I5154_RS26170	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5154_RS26175	COG1960	acyl-CoA dehydrogenase activity
I5154_RS26185	COG3264	Mechanosensitive ion channel
I5154_RS26185	COG1196	nuclear chromosome segregation
I5154_RS26195	COG0730	response to heat
I5154_RS26200	COG2873	o-acetylhomoserine
I5154_RS26215	COG1192	Involved in chromosome partitioning
I5154_RS26220	COG0583	DNA-binding transcription factor activity
I5154_RS26225	COG2814	Major facilitator Superfamily
I5154_RS26250	COG0493	'glutamate synthase
I5154_RS26255	COG0067	glutamate synthase
I5154_RS26255	COG0069	glutamate synthase activity
I5154_RS26255	COG0070	glutamate synthase
I5154_RS26315	COG0281	malic enzyme
I5154_RS26335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5154_RS26445	COG0840	transmembrane signaling receptor activity
I5154_RS26455	COG1126	abc transporter atp-binding protein
I5154_RS26460	COG0765	amino acid transport
I5154_RS26490	COG1051	belongs to the nudix hydrolase family
I5154_RS26495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5154_RS26500	COG0251	oxidation-reduction process
I5154_RS26530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5154_RS26550	COG2986	histidine ammonia-lyase
I5154_RS26555	COG4175	Glycine betaine
I5154_RS26560	COG4176	ABC-type proline glycine betaine transport system permease component
I5154_RS26580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5154_RS26615	COG0402	S-adenosylhomocysteine deaminase activity
I5154_RS26665	COG0789	Transcriptional regulator
I5154_RS26670	COG1217	gtp-binding protein TYPA
I5154_RS26690	COG0668	transmembrane transport
I5154_RS26705	COG3852	Histidine kinase
I5154_RS26720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5154_RS26750	COG4942	peptidase
I5154_RS26755	COG0793	Belongs to the peptidase S41A family
I5154_RS26760	COG2861	carbohydrate metabolic process
I5154_RS26820	COG0579	oxidoreductase
I5154_RS26830	COG1194	a g-specific adenine glycosylase
I5154_RS26840	COG0673	inositol 2-dehydrogenase activity
I5154_RS26850	COG0582	viral genome integration into host DNA
I5154_RS26855	COG0582	viral genome integration into host DNA
I5154_RS26955	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS26990	COG1846	Transcriptional regulator
I5154_RS27000	COG1566	PFAM secretion protein HlyD family protein
I5154_RS27005	COG2814	Major facilitator Superfamily
I5154_RS27015	COG4695	Portal protein
I5154_RS27215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5154_RS27250	COG1088	dTDP-glucose 4,6-dehydratase activity
I5154_RS27255	COG1091	dTDP-4-dehydrorhamnose reductase activity
I5154_RS27330	COG1218	3'(2'),5'-bisphosphate nucleotidase
I5154_RS27335	COG0494	nUDIX hydrolase
I5154_RS27340	COG1011	Hydrolase
I5154_RS27345	COG1652	LysM domain
I5154_RS27355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5154_RS27375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5154_RS27385	COG0824	Thioesterase
I5154_RS27390	COG1454	alcohol dehydrogenase
I5154_RS27395	COG1960	acyl-CoA dehydrogenase activity
I5154_RS27400	COG1024	Enoyl-CoA hydratase
I5154_RS27400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5154_RS27410	COG0778	Nitroreductase
I5154_RS27440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5154_RS27445	COG4067	protein conserved in archaea
I5154_RS27445	COG0189	ligase activity
I5154_RS27470	COG2183	response to ionizing radiation
I5154_RS27500	COG0306	phosphate transporter
I5154_RS27505	COG1392	Phosphate transport regulator
I5154_RS27510	COG3025	triphosphatase activity
I5154_RS27515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5154_RS27545	COG1178	ABC-type Fe3 transport system permease component
I5154_RS27555	COG0583	DNA-binding transcription factor activity
I5154_RS27570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5154_RS27580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5154_RS27585	COG0006	proline dipeptidase activity
I5154_RS27610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5154_RS27620	COG0842	Transport permease protein
I5154_RS27625	COG1129	ABC transporter
I5154_RS27625	COG0842	Transport permease protein
I5154_RS27630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5154_RS27645	COG2271	Major facilitator Superfamily
I5154_RS27660	COG2755	lipolytic protein G-D-S-L family
I5154_RS27660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5154_RS27675	COG0248	Ppx GppA phosphatase
I5154_RS27690	COG0586	Pfam SNARE associated Golgi protein
I5154_RS27695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5154_RS27700	COG2050	protein possibly involved in aromatic compounds catabolism
I5154_RS27710	COG0672	)-iron permease
I5154_RS27715	COG1280	lysine exporter protein (LysE YggA)
I5154_RS27720	COG0861	Integral membrane protein TerC family
I5154_RS27730	COG0488	(ABC) transporter
I5154_RS27785	COG3275	phosphorelay sensor kinase activity
I5154_RS27820	COG0598	Magnesium transport protein CorA
I5154_RS27850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5154_RS27915	COG0432	Pfam Uncharacterised protein family UPF0047
I5154_RS27920	COG0004	ammonium transporteR
I5154_RS27925	COG0347	Belongs to the P(II) protein family
I5154_RS27955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5154_RS27980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I5154_RS28015	COG2199	diguanylate cyclase activity
I5154_RS28015	COG2203	Gaf domain
I5154_RS28025	COG5006	permease, DMT superfamily
I5154_RS28045	COG3214	Protein conserved in bacteria
I5154_RS28100	COG1917	Cupin 2, conserved barrel domain protein
I5154_RS28100	COG2169	Transcriptional regulator
I5154_RS28110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5154_RS28150	COG0842	Transport permease protein
I5154_RS28155	COG0842	Transport permease protein
I5154_RS28160	COG1131	(ABC) transporter
I5154_RS28175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5154_RS28220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5154_RS28230	COG0583	DNA-binding transcription factor activity
I5154_RS28245	COG0210	DNA helicase
I5154_RS28250	COG0028	Belongs to the TPP enzyme family
I5154_RS28260	COG0427	acetyl-CoA hydrolase
I5154_RS28270	COG1396	sequence-specific DNA binding
I5154_RS28270	COG1917	Cupin 2, conserved barrel domain protein
I5154_RS28280	COG0251	oxidation-reduction process
I5154_RS28310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS28315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5154_RS28320	COG2814	Major facilitator Superfamily
I5154_RS28325	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS28330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5154_RS28350	COG0747	negative chemotaxis
I5154_RS28365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5154_RS28405	COG3245	cytochrome
I5154_RS28425	COG0708	Exodeoxyribonuclease III
I5154_RS28440	COG1561	YicC-like family, N-terminal region
I5154_RS28455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5154_RS28475	COG2207	Transcriptional regulator
I5154_RS28475	COG4753	response regulator
I5154_RS28485	COG0583	DNA-binding transcription factor activity
I5154_RS28490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5154_RS28525	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I5154_RS28530	COG0247	lactate metabolic process
I5154_RS28535	COG0277	FAD linked oxidase domain protein
I5154_RS28540	COG0277	FAD linked oxidase domain protein
I5154_RS28545	COG2186	Transcriptional regulator
I5154_RS28575	COG1253	flavin adenine dinucleotide binding
I5154_RS28580	COG0739	heme binding
I5154_RS28600	COG0573	inorganic phosphate transmembrane transporter activity
I5154_RS28645	COG0477	Major facilitator Superfamily
I5154_RS28650	COG1607	acyl-coa hydrolase
I5154_RS28670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5154_RS28675	COG4175	Glycine betaine
I5154_RS28680	COG4176	ABC-type proline glycine betaine transport system permease component
I5154_RS28690	COG1760	l-serine dehydratase
I5154_RS28705	COG0583	DNA-binding transcription factor activity
I5154_RS28715	COG0657	acetylesterase activity
I5154_RS28730	COG3246	L-lysine catabolic process to acetate
I5154_RS28785	COG1902	pentaerythritol trinitrate reductase activity
I5154_RS28785	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5154_RS28790	COG0247	lactate metabolic process
I5154_RS28790	COG2181	nitrate reductase activity
I5154_RS28795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I5154_RS28810	COG3655	Transcriptional regulator
I5154_RS28850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5154_RS28850	COG1017	nitric oxide dioxygenase activity
I5154_RS28935	COG0583	DNA-binding transcription factor activity
I5154_RS28945	COG2391	methyltransferase activity
I5154_RS28970	COG0511	ligase activity, forming carbon-carbon bonds
I5154_RS28970	COG5016	pyruvate
I5154_RS28975	COG0439	Biotin carboxylase
I5154_RS28980	COG0583	DNA-binding transcription factor activity
I5154_RS28995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5154_RS29000	COG0826	peptidase U32
I5154_RS29020	COG0210	DNA helicase
I5154_RS29030	COG0427	acetyl-CoA hydrolase
I5154_RS29045	COG0438	transferase activity, transferring glycosyl groups
I5154_RS29095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5154_RS29100	COG2755	lipolytic protein G-D-S-L family
I5154_RS29100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5154_RS29140	COG0679	Auxin Efflux Carrier
I5154_RS29150	COG2851	Citrate transporter
I5154_RS29155	COG0861	Integral membrane protein TerC family
I5154_RS29160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5154_RS29165	COG1690	Belongs to the RtcB family
I5154_RS29200	COG0700	Nucleoside recognition
I5154_RS29205	COG1301	dicarboxylic acid transport
I5154_RS29225	COG5002	protein histidine kinase activity
I5154_RS29230	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5154_RS29235	COG2095	MarC family integral membrane protein
I5154_RS29260	COG3245	cytochrome
I5154_RS29295	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5154_RS29300	COG0735	belongs to the Fur family
I5154_RS29310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5154_RS29325	COG2011	ABC-type metal ion transport system permease component
I5154_RS29355	COG0531	amino acid
I5154_RS29365	COG4191	Histidine kinase
I5154_RS29395	COG4651	solute:proton antiporter activity
I5154_RS29395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5154_RS29400	COG1607	acyl-coa hydrolase
I5154_RS29410	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS29415	COG0174	glutamine synthetase
I5154_RS29420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5154_RS29425	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS29450	COG4651	solute:proton antiporter activity
I5154_RS29450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5154_RS29455	COG0477	Major facilitator Superfamily
I5154_RS29465	COG0523	cobalamin synthesis protein
I5154_RS29510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5154_RS29530	COG2358	TRAP transporter, solute receptor (TAXI family
I5154_RS29535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5154_RS29590	COG1349	DNA-binding transcription factor activity
I5154_RS29650	COG1475	DNA binding
I5154_RS29655	COG1192	Involved in chromosome partitioning
I5154_RS29725	COG2010	Cytochrome c
I5154_RS29740	COG2818	Glycosylase
I5154_RS29755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5154_RS29770	COG0569	domain protein
I5154_RS29790	COG1652	LysM domain
I5154_RS29795	COG0758	DNA mediated transformation
I5154_RS29825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5154_RS29845	COG3119	arylsulfatase activity
I5154_RS29850	COG0583	DNA-binding transcription factor activity
I5154_RS29885	COG3360	Dodecin
I5154_RS29900	COG3210	domain, Protein
I5154_RS29900	COG3210	domain, Protein
I5154_RS29935	COG3174	membrane
I5154_RS29980	COG0367	asparagine synthase
I5154_RS30000	COG0583	DNA-binding transcription factor activity
I5154_RS30015	COG1764	response to oxidative stress
I5154_RS30050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5154_RS30055	COG0339	signal peptide processing
I5154_RS30060	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5154_RS30075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5154_RS30090	COG2815	serine threonine protein kinase
I5154_RS30090	COG0515	serine threonine protein kinase
I5154_RS30095	COG0631	protein serine/threonine phosphatase activity
I5154_RS30110	COG1360	Flagellar Motor Protein
I5154_RS30240	COG0659	secondary active sulfate transmembrane transporter activity
I5154_RS30250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5154_RS30255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5154_RS30260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I5154_RS30300	COG2153	protein acetylation
I5154_RS30340	COG0583	DNA-binding transcription factor activity
I5154_RS30365	COG2824	Alkylphosphonate utilization operon protein PhnA
I5154_RS30395	COG0402	S-adenosylhomocysteine deaminase activity
I5154_RS30400	COG3845	ABC transporter
I5154_RS30405	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5154_RS30410	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5154_RS30485	COG0583	DNA-binding transcription factor activity
I5154_RS30490	COG3485	protocatechuate 3,4-dioxygenase
I5154_RS30495	COG3485	protocatechuate 3,4-dioxygenase
I5154_RS30500	COG1414	Transcriptional regulator
I5154_RS30515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5154_RS30520	COG0583	DNA-binding transcription factor activity
I5154_RS30555	COG2233	PERMEase
I5154_RS30560	COG1309	transcriptional regulator
I5154_RS30595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I5154_RS30610	COG0835	chemotaxis
I5154_RS30615	COG0643	Histidine kinase
I5154_RS30615	COG2198	Histidine kinase
I5154_RS30620	COG0745	RESPONSE REGULATOR receiver
I5154_RS30630	COG0583	DNA-binding transcription factor activity
I5154_RS30635	COG1028	Short-chain dehydrogenase reductase Sdr
I5154_RS30645	COG1116	anion transmembrane transporter activity
I5154_RS30650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5154_RS30655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5154_RS30695	COG2175	clavaminate synthase activity
I5154_RS30770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5154_RS30795	COG1012	belongs to the aldehyde dehydrogenase family
I5154_RS30800	COG1113	amino acid transport
I5154_RS30815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5154_RS30820	COG0235	Class ii aldolase
I5154_RS30825	COG1396	sequence-specific DNA binding
I5154_RS30830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5154_RS30835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5154_RS30845	COG0477	Major facilitator Superfamily
I5154_RS30855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5154_RS30860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5154_RS30865	COG0583	DNA-binding transcription factor activity
I5154_RS30885	COG0673	inositol 2-dehydrogenase activity
I5154_RS30905	COG2271	Major facilitator Superfamily
I5154_RS30915	COG1309	transcriptional regulator
I5154_RS30920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5154_RS30930	COG0477	Major facilitator Superfamily
I5154_RS30950	COG2239	Acts as a magnesium transporter
I5154_RS31055	COG2252	PERMEase
I5154_RS31065	COG0402	S-adenosylhomocysteine deaminase activity
I5154_RS31095	COG1196	nuclear chromosome segregation
I5154_RS31125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5154_RS31140	COG1960	acyl-CoA dehydrogenase activity
I5154_RS31170	COG2076	Multidrug Resistance protein
I5154_RS31210	COG2217	Heavy metal translocating P-type atpase
I5154_RS31220	COG0348	domain, Protein
I5154_RS31225	COG2010	Cytochrome c
I5154_RS31240	COG3278	Belongs to the heme-copper respiratory oxidase family
I5154_RS31245	COG2010	Cytochrome c
I5154_RS31260	COG3278	Belongs to the heme-copper respiratory oxidase family
I5154_RS31275	COG0840	transmembrane signaling receptor activity
I5154_RS31295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS31300	COG0174	glutamine synthetase
I5154_RS31310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5154_RS31315	COG0251	oxidation-reduction process
I5154_RS31340	COG3738	Protein conserved in bacteria
I5154_RS31355	COG2084	Dehydrogenase
I5154_RS31385	COG4804	nuclease activity
I5154_RS31390	COG2003	Belongs to the UPF0758 family
I5154_RS31405	COG1475	DNA binding
I5154_RS31415	COG5489	Protein of unknown function (DUF736)
I5154_RS31460	COG4959	Type IV secretory pathway protease TraF
I5154_RS31480	COG1127	ABC transporter
I5154_RS31485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5154_RS31520	COG0583	DNA-binding transcription factor activity
I5154_RS31530	COG2076	Multidrug Resistance protein
I5154_RS31560	COG4962	Type ii secretion system protein e
I5154_RS31565	COG3838	Conjugal transfer protein Trbc
I5154_RS31575	COG3451	type IV secretory pathway VirB4
I5154_RS31590	COG3846	protein secretion by the type IV secretion system
I5154_RS31620	COG2009	succinate dehydrogenase
I5154_RS31625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5154_RS31630	COG1053	succinate dehydrogenase
I5154_RS31635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5154_RS31710	COG2207	Transcriptional regulator
I5154_RS31715	COG2010	Cytochrome c
I5154_RS31715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5154_RS31720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5154_RS31720	COG2010	Cytochrome c
I5154_RS31725	COG2080	2 iron, 2 sulfur cluster binding
I5154_RS31730	COG1846	Transcriptional regulator
I5154_RS31770	COG0784	Response regulator, receiver
I5154_RS31770	COG5002	protein histidine kinase activity
I5154_RS31770	COG2205	protein histidine kinase activity
I5154_RS31800	COG1022	Amp-dependent synthetase and ligase
I5154_RS31830	COG0625	glutathione transferase activity
I5154_RS31840	COG0628	permease
I5154_RS31845	COG2807	transmembrane transport
I5154_RS31850	COG2186	Transcriptional regulator
I5154_RS31855	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5154_RS31860	COG1024	Enoyl-CoA hydratase
I5154_RS31870	COG1960	acyl-CoA dehydrogenase activity
I5154_RS31895	COG2205	protein histidine kinase activity
I5154_RS31900	COG0745	RESPONSE REGULATOR receiver
I5154_RS31940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5154_RS31950	COG0840	transmembrane signaling receptor activity
I5154_RS31960	COG2130	NADP-dependent
I5154_RS31975	COG3135	benzoate transporter
I5154_RS31990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5154_RS31995	COG0625	glutathione transferase activity
I5154_RS32065	COG2204	response regulator
I5154_RS32105	COG2815	serine threonine protein kinase
I5154_RS32105	COG0515	serine threonine protein kinase
I5154_RS32125	COG2840	Smr protein MutS2
I5154_RS32205	COG4792	protein secretion
I5154_RS32210	COG4791	protein targeting
I5154_RS32215	COG4794	Type iii secretion
I5154_RS32220	COG4790	Type iii secretion
I5154_RS32270	COG4789	Type iii secretion
I5154_RS32380	COG1317	bacterial-type flagellum organization
I5154_RS32405	COG2308	Evidence 4 Homologs of previously reported genes of
I5154_RS32415	COG1305	Transglutaminase-like
I5154_RS32435	COG0183	Belongs to the thiolase family
I5154_RS32440	COG1024	Enoyl-CoA hydratase
I5154_RS32440	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5154_RS32450	COG0667	Aldo Keto reductase
I5154_RS32465	COG0519	Catalyzes the synthesis of GMP from XMP