locus-tag	class	description
HW07_RS00135	COG0739	heme binding
HW07_RS00165	COG1981	membrane
HW07_RS00190	COG0537	adenosine 5'-monophosphoramidase activity
HW07_RS00205	COG1765	OsmC-like protein
HW07_RS00325	COG3179	chitinase
HW07_RS00340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW07_RS00365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW07_RS00375	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW07_RS00385	COG3842	ATPase activity
HW07_RS00395	COG2197	response regulator
HW07_RS00410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HW07_RS00460	COG2766	serine protein kinase
HW07_RS00470	COG2719	SpoVR family
HW07_RS00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW07_RS00580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW07_RS00585	COG1917	Cupin 2, conserved barrel domain protein
HW07_RS00585	COG4977	sequence-specific DNA binding
HW07_RS00590	COG3152	Membrane
HW07_RS00595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW07_RS00605	COG1451	nucleotide metabolic process
HW07_RS00610	COG2081	HI0933 family
HW07_RS00650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW07_RS00655	COG3622	Belongs to the hyi family
HW07_RS00665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW07_RS00670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW07_RS00725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW07_RS00735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS00755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW07_RS00765	COG2258	MOSC domain
HW07_RS00770	COG0583	DNA-binding transcription factor activity
HW07_RS00775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW07_RS00860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW07_RS00860	COG1648	precorrin-2 dehydrogenase activity
HW07_RS00870	COG1960	acyl-CoA dehydrogenase activity
HW07_RS00875	COG1960	acyl-CoA dehydrogenase activity
HW07_RS00880	COG1960	acyl-CoA dehydrogenase activity
HW07_RS00900	COG1073	alpha beta
HW07_RS00900	COG2226	methyltransferase
HW07_RS00915	COG3121	Chaperone
HW07_RS00930	COG1984	allophanate hydrolase subunit 2
HW07_RS00945	COG0511	ligase activity, forming carbon-carbon bonds
HW07_RS00965	COG1040	competence protein
HW07_RS00970	COG5544	Lipoprotein
HW07_RS00975	COG3585	molybdate ion transport
HW07_RS00975	COG2005	Transcriptional regulator
HW07_RS01010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW07_RS01030	COG1953	Uracil, thiamine, allantoin
HW07_RS01035	COG1309	transcriptional regulator
HW07_RS01045	COG0625	glutathione transferase activity
HW07_RS01050	COG1595	DNA-templated transcription, initiation
HW07_RS01055	COG3712	iron ion homeostasis
HW07_RS01060	COG4774	siderophore transport
HW07_RS01090	COG4452	Inner membrane protein CreD
HW07_RS01095	COG2205	protein histidine kinase activity
HW07_RS01100	COG0745	RESPONSE REGULATOR receiver
HW07_RS01110	COG0204	Acyl-transferase
HW07_RS01120	COG0542	response to heat
HW07_RS01125	COG0477	Major facilitator Superfamily
HW07_RS01135	COG0189	ligase activity
HW07_RS01135	COG4067	protein conserved in archaea
HW07_RS01145	COG0513	Belongs to the DEAD box helicase family
HW07_RS01150	COG1289	transmembrane transporter activity
HW07_RS01160	COG0330	HflC and HflK could
HW07_RS01170	COG0306	phosphate transporter
HW07_RS01180	COG0583	DNA-binding transcription factor activity
HW07_RS01185	COG1960	acyl-CoA dehydrogenase activity
HW07_RS01200	COG1953	Uracil, thiamine, allantoin
HW07_RS01225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW07_RS01230	COG0402	S-adenosylhomocysteine deaminase activity
HW07_RS01235	COG1309	transcriptional regulator
HW07_RS01260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW07_RS01265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW07_RS01275	COG0513	Belongs to the DEAD box helicase family
HW07_RS01305	COG3038	cytochrome b561
HW07_RS01320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW07_RS01350	COG0643	Histidine kinase
HW07_RS01350	COG0784	Response regulator, receiver
HW07_RS01350	COG2198	Histidine kinase
HW07_RS01415	COG0626	cystathionine gamma-synthase activity
HW07_RS01460	COG1872	DUF167
HW07_RS01465	COG1160	GTP binding
HW07_RS01475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW07_RS01475	COG2813	Specifically methylates the guanine in position
HW07_RS01490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW07_RS01525	COG2363	Small membrane protein
HW07_RS01545	COG2177	Part of the ABC transporter FtsEX involved in
HW07_RS01550	COG2884	Cell division ATP-binding protein ftsE
HW07_RS01555	COG0552	protein localization to endoplasmic reticulum
HW07_RS01560	COG0612	Peptidase, M16
HW07_RS01565	COG0612	Peptidase, M16
HW07_RS01570	COG0742	ribosomal rna small subunit methyltransferase
HW07_RS01580	COG0429	hydrolase of the alpha beta-hydrolase fold
HW07_RS01605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HW07_RS01615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW07_RS01650	COG0693	protein deglycase activity
HW07_RS01665	COG2233	PERMEase
HW07_RS01670	COG0622	Phosphoesterase
HW07_RS01690	COG0584	glycerophosphoryl diester phosphodiesterase
HW07_RS01725	COG0730	response to heat
HW07_RS01765	COG0702	epimerase
HW07_RS01775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW07_RS01795	COG2234	aminopeptidase activity
HW07_RS01800	COG3204	pilus organization
HW07_RS01805	COG3842	ATPase activity
HW07_RS01815	COG1177	transmembrane transport
HW07_RS01820	COG2182	Extracellular solute-binding protein
HW07_RS01825	COG0531	amino acid
HW07_RS01835	COG3111	PFAM Bacterial OB fold (BOF) protein
HW07_RS01845	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW07_RS01850	COG0277	FAD linked oxidase domain protein
HW07_RS01855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW07_RS01870	COG0765	amino acid transport
HW07_RS01920	COG1177	transmembrane transport
HW07_RS01925	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW07_RS01930	COG3842	ATPase activity
HW07_RS01950	COG0174	glutamine synthetase
HW07_RS01955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW07_RS01960	COG0174	glutamine synthetase
HW07_RS01965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW07_RS01990	COG2199	diguanylate cyclase activity
HW07_RS02005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW07_RS02025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HW07_RS02035	COG4208	sulfate ABC transporter
HW07_RS02055	COG0501	Belongs to the peptidase M48B family
HW07_RS02075	COG2807	transmembrane transport
HW07_RS02080	COG0583	DNA-binding transcription factor activity
HW07_RS02095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW07_RS02105	COG0745	RESPONSE REGULATOR receiver
HW07_RS02180	COG0582	viral genome integration into host DNA
HW07_RS02335	COG2239	Acts as a magnesium transporter
HW07_RS02355	COG0477	Major facilitator Superfamily
HW07_RS02365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW07_RS02370	COG1309	transcriptional regulator
HW07_RS02380	COG2271	Major facilitator Superfamily
HW07_RS02400	COG0673	inositol 2-dehydrogenase activity
HW07_RS02420	COG0583	DNA-binding transcription factor activity
HW07_RS02425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW07_RS02430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW07_RS02440	COG0477	Major facilitator Superfamily
HW07_RS02450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW07_RS02455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW07_RS02460	COG1396	sequence-specific DNA binding
HW07_RS02465	COG0235	Class ii aldolase
HW07_RS02470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW07_RS02485	COG1113	amino acid transport
HW07_RS02490	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS02520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW07_RS02595	COG2175	clavaminate synthase activity
HW07_RS02635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS02640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW07_RS02645	COG1116	anion transmembrane transporter activity
HW07_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS02660	COG0583	DNA-binding transcription factor activity
HW07_RS02670	COG0745	RESPONSE REGULATOR receiver
HW07_RS02675	COG2198	Histidine kinase
HW07_RS02675	COG0643	Histidine kinase
HW07_RS02695	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HW07_RS02730	COG1309	transcriptional regulator
HW07_RS02735	COG2233	PERMEase
HW07_RS02770	COG0583	DNA-binding transcription factor activity
HW07_RS02775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS02790	COG1414	Transcriptional regulator
HW07_RS02795	COG3485	protocatechuate 3,4-dioxygenase
HW07_RS02800	COG3485	protocatechuate 3,4-dioxygenase
HW07_RS02805	COG0583	DNA-binding transcription factor activity
HW07_RS02875	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW07_RS02880	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW07_RS02885	COG3845	ABC transporter
HW07_RS02895	COG0402	S-adenosylhomocysteine deaminase activity
HW07_RS02925	COG2824	Alkylphosphonate utilization operon protein PhnA
HW07_RS02950	COG0583	DNA-binding transcription factor activity
HW07_RS02990	COG2153	protein acetylation
HW07_RS03030	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HW07_RS03035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW07_RS03040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW07_RS03050	COG0659	secondary active sulfate transmembrane transporter activity
HW07_RS03180	COG1360	Flagellar Motor Protein
HW07_RS03195	COG0631	protein serine/threonine phosphatase activity
HW07_RS03200	COG2815	serine threonine protein kinase
HW07_RS03200	COG0515	serine threonine protein kinase
HW07_RS03215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HW07_RS03230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HW07_RS03235	COG0339	signal peptide processing
HW07_RS03240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW07_RS03275	COG1764	response to oxidative stress
HW07_RS03290	COG0583	DNA-binding transcription factor activity
HW07_RS03310	COG0367	asparagine synthase
HW07_RS03350	COG3174	membrane
HW07_RS03385	COG3360	Dodecin
HW07_RS03420	COG0583	DNA-binding transcription factor activity
HW07_RS03425	COG3119	arylsulfatase activity
HW07_RS03445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW07_RS03475	COG0758	DNA mediated transformation
HW07_RS03480	COG1652	LysM domain
HW07_RS03500	COG0569	domain protein
HW07_RS03515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HW07_RS03530	COG2818	Glycosylase
HW07_RS03545	COG2010	Cytochrome c
HW07_RS03615	COG1192	Involved in chromosome partitioning
HW07_RS03620	COG1475	DNA binding
HW07_RS03680	COG1349	DNA-binding transcription factor activity
HW07_RS03700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW07_RS03705	COG2358	TRAP transporter, solute receptor (TAXI family
HW07_RS03725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW07_RS03770	COG0523	cobalamin synthesis protein
HW07_RS03780	COG0477	Major facilitator Superfamily
HW07_RS03785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW07_RS03785	COG4651	solute:proton antiporter activity
HW07_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS03815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW07_RS03820	COG0174	glutamine synthetase
HW07_RS03825	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS03835	COG1607	acyl-coa hydrolase
HW07_RS03840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW07_RS03840	COG4651	solute:proton antiporter activity
HW07_RS03870	COG4191	Histidine kinase
HW07_RS03880	COG0531	amino acid
HW07_RS03910	COG2011	ABC-type metal ion transport system permease component
HW07_RS03925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW07_RS03935	COG0735	belongs to the Fur family
HW07_RS03940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HW07_RS03975	COG3245	cytochrome
HW07_RS04000	COG2095	MarC family integral membrane protein
HW07_RS04005	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW07_RS04010	COG5002	protein histidine kinase activity
HW07_RS04035	COG1301	dicarboxylic acid transport
HW07_RS04040	COG0700	Nucleoside recognition
HW07_RS04075	COG1690	Belongs to the RtcB family
HW07_RS04080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW07_RS04085	COG0861	Integral membrane protein TerC family
HW07_RS04090	COG2851	Citrate transporter
HW07_RS04100	COG0679	Auxin Efflux Carrier
HW07_RS04140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW07_RS04140	COG2755	lipolytic protein G-D-S-L family
HW07_RS04145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW07_RS04190	COG0438	transferase activity, transferring glycosyl groups
HW07_RS04205	COG0427	acetyl-CoA hydrolase
HW07_RS04215	COG0210	DNA helicase
HW07_RS04235	COG0826	peptidase U32
HW07_RS04240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW07_RS04255	COG0583	DNA-binding transcription factor activity
HW07_RS04260	COG0439	Biotin carboxylase
HW07_RS04265	COG5016	pyruvate
HW07_RS04265	COG0511	ligase activity, forming carbon-carbon bonds
HW07_RS04290	COG2391	methyltransferase activity
HW07_RS04300	COG0583	DNA-binding transcription factor activity
HW07_RS04385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW07_RS04385	COG1017	nitric oxide dioxygenase activity
HW07_RS04425	COG3655	Transcriptional regulator
HW07_RS04445	COG2181	nitrate reductase activity
HW07_RS04445	COG0247	lactate metabolic process
HW07_RS04450	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS04450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW07_RS04505	COG3246	L-lysine catabolic process to acetate
HW07_RS04520	COG0657	acetylesterase activity
HW07_RS04530	COG0583	DNA-binding transcription factor activity
HW07_RS04545	COG1760	l-serine dehydratase
HW07_RS04555	COG4176	ABC-type proline glycine betaine transport system permease component
HW07_RS04560	COG4175	Glycine betaine
HW07_RS04565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW07_RS04585	COG1607	acyl-coa hydrolase
HW07_RS04590	COG0477	Major facilitator Superfamily
HW07_RS04630	COG0573	inorganic phosphate transmembrane transporter activity
HW07_RS04650	COG0739	heme binding
HW07_RS04655	COG1253	flavin adenine dinucleotide binding
HW07_RS04685	COG2186	Transcriptional regulator
HW07_RS04690	COG0277	FAD linked oxidase domain protein
HW07_RS04695	COG0277	FAD linked oxidase domain protein
HW07_RS04700	COG0247	lactate metabolic process
HW07_RS04705	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HW07_RS04740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW07_RS04745	COG0583	DNA-binding transcription factor activity
HW07_RS04775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW07_RS04790	COG1561	YicC-like family, N-terminal region
HW07_RS04805	COG0708	Exodeoxyribonuclease III
HW07_RS04825	COG3245	cytochrome
HW07_RS04865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW07_RS04880	COG0747	negative chemotaxis
HW07_RS04900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW07_RS04905	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS04910	COG2814	Major facilitator Superfamily
HW07_RS04915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW07_RS04920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS04950	COG0251	oxidation-reduction process
HW07_RS04960	COG1396	sequence-specific DNA binding
HW07_RS04960	COG1917	Cupin 2, conserved barrel domain protein
HW07_RS04970	COG0427	acetyl-CoA hydrolase
HW07_RS04980	COG0028	Belongs to the TPP enzyme family
HW07_RS04985	COG0210	DNA helicase
HW07_RS05000	COG0583	DNA-binding transcription factor activity
HW07_RS05010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW07_RS05015	COG0606	chelatase, subunit chli
HW07_RS05025	COG0347	Belongs to the P(II) protein family
HW07_RS05030	COG0004	ammonium transporteR
HW07_RS05035	COG0432	Pfam Uncharacterised protein family UPF0047
HW07_RS05095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW07_RS05125	COG0598	Magnesium transport protein CorA
HW07_RS05155	COG3275	phosphorelay sensor kinase activity
HW07_RS05210	COG0488	(ABC) transporter
HW07_RS05220	COG0861	Integral membrane protein TerC family
HW07_RS05225	COG1280	lysine exporter protein (LysE YggA)
HW07_RS05230	COG0672	)-iron permease
HW07_RS05240	COG2050	protein possibly involved in aromatic compounds catabolism
HW07_RS05245	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HW07_RS05250	COG0586	Pfam SNARE associated Golgi protein
HW07_RS05265	COG0248	Ppx GppA phosphatase
HW07_RS05280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW07_RS05280	COG2755	lipolytic protein G-D-S-L family
HW07_RS05295	COG2271	Major facilitator Superfamily
HW07_RS05310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS05315	COG0842	Transport permease protein
HW07_RS05315	COG1129	ABC transporter
HW07_RS05320	COG0842	Transport permease protein
HW07_RS05330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW07_RS05355	COG0006	proline dipeptidase activity
HW07_RS05360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW07_RS05370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW07_RS05385	COG0583	DNA-binding transcription factor activity
HW07_RS05395	COG1178	ABC-type Fe3 transport system permease component
HW07_RS05425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW07_RS05430	COG3025	triphosphatase activity
HW07_RS05435	COG1392	Phosphate transport regulator
HW07_RS05440	COG0306	phosphate transporter
HW07_RS05470	COG2183	response to ionizing radiation
HW07_RS05495	COG4067	protein conserved in archaea
HW07_RS05495	COG0189	ligase activity
HW07_RS05500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW07_RS05525	COG0778	Nitroreductase
HW07_RS05535	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW07_RS05535	COG1024	Enoyl-CoA hydratase
HW07_RS05540	COG1960	acyl-CoA dehydrogenase activity
HW07_RS05545	COG1454	alcohol dehydrogenase
HW07_RS05550	COG0824	Thioesterase
HW07_RS05560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW07_RS05580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW07_RS05590	COG1652	LysM domain
HW07_RS05595	COG1011	Hydrolase
HW07_RS05600	COG0494	nUDIX hydrolase
HW07_RS05605	COG1218	3'(2'),5'-bisphosphate nucleotidase
HW07_RS05675	COG1091	dTDP-4-dehydrorhamnose reductase activity
HW07_RS05680	COG1088	dTDP-glucose 4,6-dehydratase activity
HW07_RS05725	COG0582	viral genome integration into host DNA
HW07_RS05735	COG2814	Major facilitator Superfamily
HW07_RS05740	COG1566	PFAM secretion protein HlyD family protein
HW07_RS05750	COG1846	Transcriptional regulator
HW07_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS05795	COG0673	inositol 2-dehydrogenase activity
HW07_RS05805	COG1194	a g-specific adenine glycosylase
HW07_RS05815	COG0579	oxidoreductase
HW07_RS05875	COG2861	carbohydrate metabolic process
HW07_RS05880	COG0793	Belongs to the peptidase S41A family
HW07_RS05885	COG4942	peptidase
HW07_RS05915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW07_RS05930	COG3852	Histidine kinase
HW07_RS05945	COG0668	transmembrane transport
HW07_RS05965	COG1217	gtp-binding protein TYPA
HW07_RS05970	COG0789	Transcriptional regulator
HW07_RS06020	COG0402	S-adenosylhomocysteine deaminase activity
HW07_RS06055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW07_RS06075	COG4176	ABC-type proline glycine betaine transport system permease component
HW07_RS06080	COG4175	Glycine betaine
HW07_RS06085	COG2986	histidine ammonia-lyase
HW07_RS06105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW07_RS06130	COG0251	oxidation-reduction process
HW07_RS06135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS06140	COG1051	belongs to the nudix hydrolase family
HW07_RS06170	COG0765	amino acid transport
HW07_RS06175	COG1126	abc transporter atp-binding protein
HW07_RS06185	COG0840	transmembrane signaling receptor activity
HW07_RS06295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW07_RS06315	COG0281	malic enzyme
HW07_RS06365	COG0069	glutamate synthase activity
HW07_RS06365	COG0067	glutamate synthase
HW07_RS06365	COG0070	glutamate synthase
HW07_RS06370	COG0493	'glutamate synthase
HW07_RS06395	COG2814	Major facilitator Superfamily
HW07_RS06400	COG0583	DNA-binding transcription factor activity
HW07_RS06405	COG1192	Involved in chromosome partitioning
HW07_RS06420	COG2873	o-acetylhomoserine
HW07_RS06425	COG0730	response to heat
HW07_RS06435	COG1196	nuclear chromosome segregation
HW07_RS06435	COG3264	Mechanosensitive ion channel
HW07_RS06445	COG1960	acyl-CoA dehydrogenase activity
HW07_RS06450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HW07_RS06485	COG0859	PFAM glycosyl transferase family 9
HW07_RS06490	COG0859	PFAM glycosyl transferase family 9
HW07_RS06495	COG0438	transferase activity, transferring glycosyl groups
HW07_RS06520	COG2192	nodulation
HW07_RS06525	COG0438	transferase activity, transferring glycosyl groups
HW07_RS06545	COG1215	transferase activity, transferring glycosyl groups
HW07_RS06570	COG1960	acyl-CoA dehydrogenase activity
HW07_RS06575	COG1960	acyl-CoA dehydrogenase activity
HW07_RS06585	COG0667	Aldo Keto reductase
HW07_RS06600	COG0583	DNA-binding transcription factor activity
HW07_RS06605	COG1519	Transferase
HW07_RS06615	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW07_RS06615	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS06645	COG0833	amino acid
HW07_RS06650	COG1024	Enoyl-CoA hydratase
HW07_RS06655	COG1960	acyl-CoA dehydrogenase activity
HW07_RS06660	COG0045	succinate-CoA ligase (ADP-forming) activity
HW07_RS06675	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW07_RS06680	COG1538	Outer membrane efflux protein
HW07_RS06695	COG0494	nUDIX hydrolase
HW07_RS06705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HW07_RS06710	COG3150	esterase
HW07_RS06725	COG3577	Aspartyl protease
HW07_RS06740	COG1988	membrane-bound metal-dependent
HW07_RS06750	COG3830	Belongs to the UPF0237 family
HW07_RS06750	COG0560	Phosphoserine phosphatase
HW07_RS06755	COG5001	Diguanylate cyclase
HW07_RS06755	COG3300	MHYT domain
HW07_RS06805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW07_RS06805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW07_RS06810	COG0802	atpase or kinase
HW07_RS06815	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW07_RS06835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW07_RS06840	COG0330	HflC and HflK could
HW07_RS06845	COG0330	HflC and HflK could
HW07_RS06875	COG0557	exoribonuclease II activity
HW07_RS06905	COG0305	Participates in initiation and elongation during chromosome replication
HW07_RS06915	COG3300	MHYT domain
HW07_RS06915	COG5001	Diguanylate cyclase
HW07_RS06935	COG0668	transmembrane transport
HW07_RS06975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW07_RS06990	COG0583	DNA-binding transcription factor activity
HW07_RS07020	COG2423	ornithine cyclodeaminase activity
HW07_RS07025	COG4221	oxidoreductase activity
HW07_RS07050	COG0583	DNA-binding transcription factor activity
HW07_RS07060	COG2814	Major facilitator Superfamily
HW07_RS07080	COG1595	DNA-templated transcription, initiation
HW07_RS07085	COG3712	iron ion homeostasis
HW07_RS07145	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HW07_RS07150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW07_RS07160	COG2193	ferroxidase activity
HW07_RS07165	COG2982	Protein involved in outer membrane biogenesis
HW07_RS07170	COG0789	Transcriptional regulator
HW07_RS07195	COG0443	Heat shock 70 kDa protein
HW07_RS07210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW07_RS07255	COG0411	ABC transporter
HW07_RS07270	COG0683	leucine binding
HW07_RS07275	COG2095	MarC family integral membrane protein
HW07_RS07360	COG0023	Translation Initiation Factor
HW07_RS07395	COG1272	protein, Hemolysin III
HW07_RS07400	COG4221	oxidoreductase activity
HW07_RS07425	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HW07_RS07450	COG1283	sodium-dependent phosphate transmembrane transporter activity
HW07_RS07460	COG0534	Mate efflux family protein
HW07_RS07470	COG0463	Glycosyl transferase, family 2
HW07_RS07495	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS07495	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW07_RS07500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HW07_RS07505	COG3383	formate dehydrogenase (NAD+) activity
HW07_RS07505	COG0243	molybdopterin cofactor binding
HW07_RS07510	COG0243	molybdopterin cofactor binding
HW07_RS07510	COG3383	formate dehydrogenase (NAD+) activity
HW07_RS07515	COG0437	4 iron, 4 sulfur cluster binding
HW07_RS07520	COG2864	formate dehydrogenase
HW07_RS07535	COG3276	selenocysteine insertion sequence binding
HW07_RS07590	COG0509	glycine decarboxylation via glycine cleavage system
HW07_RS07620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW07_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS07650	COG1522	sequence-specific DNA binding
HW07_RS07655	COG0697	spore germination
HW07_RS07675	COG0697	spore germination
HW07_RS07725	COG1620	l-lactate permease
HW07_RS07730	COG2186	Transcriptional regulator
HW07_RS07760	COG0497	DNA recombination
HW07_RS07825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW07_RS07860	COG0195	Participates in both transcription termination and antitermination
HW07_RS07960	COG4191	Histidine kinase
HW07_RS07975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW07_RS07980	COG0436	Aminotransferase
HW07_RS07995	COG2252	PERMEase
HW07_RS08005	COG2321	neutral zinc metallopeptidase
HW07_RS08015	COG0436	Aminotransferase
HW07_RS08040	COG4771	TonB-dependent receptor
HW07_RS08045	COG3720	iron ion transport
HW07_RS08050	COG4558	Periplasmic binding protein
HW07_RS08055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW07_RS08090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW07_RS08100	COG3098	single-species biofilm formation
HW07_RS08110	COG0028	Belongs to the TPP enzyme family
HW07_RS08125	COG1183	phosphatidylcholine synthase activity
HW07_RS08165	COG2995	paraquat-inducible protein a
HW07_RS08170	COG2995	paraquat-inducible protein a
HW07_RS08175	COG3008	intermembrane lipid transfer
HW07_RS08180	COG1178	ABC-type Fe3 transport system permease component
HW07_RS08185	COG1840	ABC-type Fe3 transport system, periplasmic component
HW07_RS08230	COG0456	acetyltransferase
HW07_RS08240	COG0288	reversible hydration of carbon dioxide
HW07_RS08310	COG4128	Pfam Zonular occludens toxin
HW07_RS08320	COG4974	Belongs to the 'phage' integrase family
HW07_RS08335	COG0012	GTP binding
HW07_RS08390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW07_RS08410	COG0789	Transcriptional regulator
HW07_RS08420	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HW07_RS08425	COG1090	epimerase
HW07_RS08480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW07_RS08540	COG1285	pathogenesis
HW07_RS08545	COG2135	peptidase activity
HW07_RS08550	COG0840	transmembrane signaling receptor activity
HW07_RS08555	COG0501	Belongs to the peptidase M48B family
HW07_RS08570	COG2119	membrane
HW07_RS08575	COG0833	amino acid
HW07_RS08585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW07_RS08620	COG2010	Cytochrome c
HW07_RS08625	COG3608	succinylglutamate desuccinylase aspartoacylase
HW07_RS08625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW07_RS08690	COG1966	Carbon starvation protein
HW07_RS08695	COG2879	small protein
HW07_RS08700	COG0523	cobalamin synthesis protein
HW07_RS08725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS08730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS08750	COG0488	(ABC) transporter
HW07_RS08755	COG0577	efflux transmembrane transporter activity
HW07_RS08755	COG1136	(ABC) transporter
HW07_RS08760	COG0577	efflux transmembrane transporter activity
HW07_RS08760	COG1136	(ABC) transporter
HW07_RS08785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW07_RS08805	COG3541	Predicted nucleotidyltransferase
HW07_RS08810	COG1690	Belongs to the RtcB family
HW07_RS08825	COG4650	regulator
HW07_RS08850	COG1067	ATP-dependent peptidase activity
HW07_RS08870	COG0545	Peptidyl-prolyl cis-trans isomerase
HW07_RS08885	COG0142	geranyltranstransferase activity
HW07_RS08910	COG3045	CreA protein
HW07_RS08925	COG0196	riboflavin kinase activity
HW07_RS08940	COG1047	Peptidyl-prolyl cis-trans
HW07_RS08980	COG4969	Belongs to the N-Me-Phe pilin family
HW07_RS09055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW07_RS09060	COG1252	NADH dehydrogenase
HW07_RS09125	COG4969	Belongs to the N-Me-Phe pilin family
HW07_RS09165	COG0019	diaminopimelate decarboxylase activity
HW07_RS09175	COG2194	sulfuric ester hydrolase activity
HW07_RS09190	COG4774	siderophore transport
HW07_RS09195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW07_RS09215	COG1984	allophanate hydrolase subunit 2
HW07_RS09230	COG4608	Belongs to the ABC transporter superfamily
HW07_RS09235	COG0444	Belongs to the ABC transporter superfamily
HW07_RS09240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW07_RS09245	COG0601	transmembrane transport
HW07_RS09250	COG0747	negative chemotaxis
HW07_RS09260	COG0747	negative chemotaxis
HW07_RS09275	COG0747	negative chemotaxis
HW07_RS09280	COG0747	negative chemotaxis
HW07_RS09295	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HW07_RS09300	COG4676	Protein conserved in bacteria
HW07_RS09305	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HW07_RS09320	COG5445	Predicted secreted protein (DUF2300)
HW07_RS09325	COG4676	Protein conserved in bacteria
HW07_RS09330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW07_RS09335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW07_RS09355	COG1077	Cell shape determining protein MreB Mrl
HW07_RS09360	COG1792	Involved in formation and maintenance of cell shape
HW07_RS09375	COG1530	ribonuclease E activity
HW07_RS09385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW07_RS09390	COG0312	modulator of DNA gyrase
HW07_RS09400	COG0312	modulator of DNA gyrase
HW07_RS09455	COG1137	ATPase activity
HW07_RS09470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HW07_RS09480	COG1127	ABC transporter
HW07_RS09485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW07_RS09490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW07_RS09530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW07_RS09540	COG2951	lytic endotransglycosylase activity
HW07_RS09560	COG2945	thiolester hydrolase activity
HW07_RS09570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW07_RS09585	COG1960	acyl-CoA dehydrogenase activity
HW07_RS09590	COG0667	Aldo Keto reductase
HW07_RS09605	COG0723	plastoquinol--plastocyanin reductase activity
HW07_RS09610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW07_RS09615	COG2857	Cytochrome c1
HW07_RS09620	COG0625	glutathione transferase activity
HW07_RS09625	COG2969	positive regulation of protein catabolic process
HW07_RS09630	COG2823	Periplasmic or secreted lipoprotein
HW07_RS09645	COG3107	peptidoglycan biosynthetic process
HW07_RS09685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW07_RS09700	COG0772	Belongs to the SEDS family
HW07_RS09745	COG0739	heme binding
HW07_RS09745	COG0741	lytic transglycosylase activity
HW07_RS09745	COG1196	nuclear chromosome segregation
HW07_RS09765	COG0494	nUDIX hydrolase
HW07_RS09770	COG2096	Adenosyltransferase
HW07_RS09785	COG0745	RESPONSE REGULATOR receiver
HW07_RS09795	COG0668	transmembrane transport
HW07_RS09820	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS09830	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW07_RS09865	COG0745	RESPONSE REGULATOR receiver
HW07_RS09870	COG2205	protein histidine kinase activity
HW07_RS09880	COG3642	lipopolysaccharide core region biosynthetic process
HW07_RS09895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS09900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS09925	COG1704	LemA family
HW07_RS09965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW07_RS09980	COG1918	ferrous iron import across plasma membrane
HW07_RS09995	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS10000	COG2814	Major facilitator Superfamily
HW07_RS10015	COG0589	response to stress
HW07_RS10035	COG0426	domain, Protein
HW07_RS10035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW07_RS10040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW07_RS10055	COG1473	amidohydrolase
HW07_RS10065	COG0154	amidase activity
HW07_RS10080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW07_RS10095	COG0693	protein deglycase activity
HW07_RS10115	COG3706	GGDEF domain
HW07_RS10125	COG1024	Enoyl-CoA hydratase
HW07_RS10135	COG0589	response to stress
HW07_RS10165	COG0714	Associated with various cellular activities
HW07_RS10195	COG2925	Exonuclease
HW07_RS10205	COG0788	formyltetrahydrofolate deformylase activity
HW07_RS10240	COG0433	COG0433 Predicted ATPase
HW07_RS10260	COG4964	Belongs to the GSP D family
HW07_RS10320	COG0306	phosphate transporter
HW07_RS10330	COG0840	transmembrane signaling receptor activity
HW07_RS10345	COG0697	spore germination
HW07_RS10350	COG0095	Lipoate-protein ligase
HW07_RS10355	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HW07_RS10360	COG1074	ATP-dependent DNA helicase activity
HW07_RS10365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW07_RS10375	COG0420	3'-5' exonuclease activity
HW07_RS10525	COG2831	hemolysin activation secretion protein
HW07_RS10560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW07_RS10570	COG0583	DNA-binding transcription factor activity
HW07_RS10590	COG0154	amidase activity
HW07_RS10600	COG0463	Glycosyl transferase, family 2
HW07_RS10615	COG0583	DNA-binding transcription factor activity
HW07_RS10715	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW07_RS10720	COG2910	NAD(P)H-binding
HW07_RS10740	COG1024	Enoyl-CoA hydratase
HW07_RS10745	COG1960	acyl-CoA dehydrogenase activity
HW07_RS10760	COG2720	vancomycin resistance protein
HW07_RS10770	COG3180	Ammonia monooxygenase
HW07_RS10850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW07_RS10915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW07_RS10925	COG4206	TonB-dependent receptor
HW07_RS10935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW07_RS10940	COG0583	DNA-binding transcription factor activity
HW07_RS10970	COG1113	amino acid transport
HW07_RS10985	COG2079	MmgE PrpD family protein
HW07_RS11000	COG0372	Belongs to the citrate synthase family
HW07_RS11010	COG1802	Transcriptional regulator
HW07_RS11020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW07_RS11045	COG0656	L-ascorbic acid biosynthetic process
HW07_RS11060	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW07_RS11075	COG0546	phosphoglycolate phosphatase activity
HW07_RS11090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW07_RS11125	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HW07_RS11175	COG2267	carboxylic ester hydrolase activity
HW07_RS11190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW07_RS11195	COG2885	chlorophyll binding
HW07_RS11200	COG0204	Acyl-transferase
HW07_RS11220	COG0386	Belongs to the glutathione peroxidase family
HW07_RS11225	COG1309	transcriptional regulator
HW07_RS11235	COG1307	EDD domain protein, DegV family
HW07_RS11270	COG0450	alkyl hydroperoxide reductase
HW07_RS11275	COG0492	ferredoxin-NADP+ reductase activity
HW07_RS11315	COG0271	Belongs to the BolA IbaG family
HW07_RS11335	COG5002	protein histidine kinase activity
HW07_RS11335	COG5001	Diguanylate cyclase
HW07_RS11345	COG0604	alcohol dehydrogenase
HW07_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS11345	COG3321	synthase
HW07_RS11365	COG1113	amino acid transport
HW07_RS11415	COG0583	DNA-binding transcription factor activity
HW07_RS11420	COG0583	DNA-binding transcription factor activity
HW07_RS11425	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HW07_RS11430	COG1960	acyl-CoA dehydrogenase activity
HW07_RS11440	COG2079	MmgE PrpD family protein
HW07_RS11450	COG2301	Belongs to the HpcH HpaI aldolase family
HW07_RS11545	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HW07_RS11615	COG2239	Acts as a magnesium transporter
HW07_RS11625	COG4807	Protein conserved in bacteria
HW07_RS11640	COG3038	cytochrome b561
HW07_RS11690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW07_RS11695	COG0784	Response regulator, receiver
HW07_RS11695	COG2205	protein histidine kinase activity
HW07_RS11695	COG5002	protein histidine kinase activity
HW07_RS11725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW07_RS11730	COG3956	TIGRFAM MazG family protein
HW07_RS11740	COG3122	Protein conserved in bacteria
HW07_RS11780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW07_RS11795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW07_RS11830	COG3118	belongs to the thioredoxin family
HW07_RS11875	COG0783	Belongs to the Dps family
HW07_RS11905	COG0824	Thioesterase
HW07_RS11935	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HW07_RS11940	COG0602	queuosine metabolic process
HW07_RS11965	COG1051	belongs to the nudix hydrolase family
HW07_RS11985	COG3188	usher protein
HW07_RS11990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW07_RS12045	COG0425	Belongs to the sulfur carrier protein TusA family
HW07_RS12055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW07_RS12070	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HW07_RS12075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW07_RS12115	COG2030	dehydratase
HW07_RS12120	COG2814	Major facilitator Superfamily
HW07_RS12130	COG1960	acyl-CoA dehydrogenase activity
HW07_RS12135	COG1024	Enoyl-CoA hydratase
HW07_RS12140	COG1960	acyl-CoA dehydrogenase activity
HW07_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS12170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS12195	COG0625	glutathione transferase activity
HW07_RS12200	COG0653	protein targeting
HW07_RS12215	COG2860	membrane
HW07_RS12255	COG1199	ATP-dependent helicase activity
HW07_RS12270	COG2885	chlorophyll binding
HW07_RS12280	COG3835	regulator
HW07_RS12285	COG2610	gluconate transmembrane transporter activity
HW07_RS12290	COG1929	Belongs to the glycerate kinase type-1 family
HW07_RS12300	COG3133	Outer membrane lipoprotein
HW07_RS12305	COG2111	Na H antiporter
HW07_RS12305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW07_RS12310	COG1006	Multisubunit Na H antiporter MnhC subunit
HW07_RS12315	COG0651	ATP synthesis coupled electron transport
HW07_RS12320	COG1863	multisubunit Na H antiporter MnhE subunit
HW07_RS12325	COG2212	antiporter activity
HW07_RS12340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW07_RS12360	COG3189	MarR family transcriptional regulator
HW07_RS12375	COG0326	Molecular chaperone. Has ATPase activity
HW07_RS12420	COG1815	bacterial-type flagellum-dependent cell motility
HW07_RS12430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW07_RS12440	COG4787	bacterial-type flagellum-dependent cell motility
HW07_RS12500	COG1334	flagellar protein FlaG
HW07_RS12560	COG2882	bacterial-type flagellum organization
HW07_RS12575	COG0477	Major facilitator Superfamily
HW07_RS12580	COG2207	Transcriptional regulator
HW07_RS12595	COG2133	pyrroloquinoline quinone binding
HW07_RS12600	COG4628	conserved protein (DUF2132)
HW07_RS12610	COG1132	(ABC) transporter
HW07_RS12640	COG2885	chlorophyll binding
HW07_RS12645	COG2199	diguanylate cyclase activity
HW07_RS12655	COG0242	peptide deformylase activity
HW07_RS12680	COG0667	Aldo Keto reductase
HW07_RS12685	COG0583	DNA-binding transcription factor activity
HW07_RS12725	COG2197	response regulator
HW07_RS12730	COG0604	alcohol dehydrogenase
HW07_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS12730	COG3321	synthase
HW07_RS12745	COG3257	ureidoglycine aminohydrolase activity
HW07_RS12750	COG0583	DNA-binding transcription factor activity
HW07_RS12780	COG0531	amino acid
HW07_RS12815	COG1943	Transposase
HW07_RS12820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW07_RS12825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW07_RS12825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW07_RS12830	COG0745	RESPONSE REGULATOR receiver
HW07_RS12835	COG2205	protein histidine kinase activity
HW07_RS12850	COG2226	methyltransferase
HW07_RS12865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW07_RS12870	COG2977	Belongs to the P-Pant transferase superfamily
HW07_RS12890	COG0753	catalase activity
HW07_RS12895	COG0861	Integral membrane protein TerC family
HW07_RS12900	COG2951	lytic endotransglycosylase activity
HW07_RS12905	COG3005	denitrification pathway
HW07_RS12910	COG3043	anaerobic respiration
HW07_RS12920	COG3062	negative regulation of establishment of protein localization
HW07_RS12925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW07_RS12925	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW07_RS12930	COG4459	periplasmic nitrate reductase
HW07_RS12950	COG5002	protein histidine kinase activity
HW07_RS12950	COG3447	MASE1 domain protein
HW07_RS12950	COG5001	Diguanylate cyclase
HW07_RS12970	COG0625	glutathione transferase activity
HW07_RS12980	COG1960	acyl-CoA dehydrogenase activity
HW07_RS12985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW07_RS13010	COG2818	Glycosylase
HW07_RS13025	COG3829	transcription factor binding
HW07_RS13035	COG0791	NLP P60 protein
HW07_RS13040	COG0791	NLP P60 protein
HW07_RS13050	COG0583	DNA-binding transcription factor activity
HW07_RS13055	COG1335	isochorismatase
HW07_RS13105	COG2211	Major facilitator Superfamily
HW07_RS13115	COG0367	asparagine synthase
HW07_RS13120	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS13130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW07_RS13155	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HW07_RS13165	COG0583	DNA-binding transcription factor activity
HW07_RS13170	COG2957	Belongs to the agmatine deiminase family
HW07_RS13185	COG2957	Belongs to the agmatine deiminase family
HW07_RS13190	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW07_RS13210	COG2207	Transcriptional regulator
HW07_RS13225	COG1289	transmembrane transporter activity
HW07_RS13280	COG4191	Histidine kinase
HW07_RS13280	COG0784	Response regulator, receiver
HW07_RS13330	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS13335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW07_RS13345	COG1126	abc transporter atp-binding protein
HW07_RS13355	COG0765	amino acid transport
HW07_RS13375	COG0477	Major facilitator Superfamily
HW07_RS13405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS13415	COG1802	Transcriptional regulator
HW07_RS13425	COG4206	TonB-dependent receptor
HW07_RS13440	COG0778	Nitroreductase
HW07_RS13470	COG0406	alpha-ribazole phosphatase activity
HW07_RS13490	COG1960	acyl-CoA dehydrogenase activity
HW07_RS13550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW07_RS13555	COG1230	cation diffusion facilitator family transporter
HW07_RS13570	COG1595	DNA-templated transcription, initiation
HW07_RS13575	COG3712	iron ion homeostasis
HW07_RS13605	COG0121	glutamine amidotransferase
HW07_RS13615	COG0583	DNA-binding transcription factor activity
HW07_RS13635	COG2814	Major facilitator Superfamily
HW07_RS13680	COG4774	siderophore transport
HW07_RS13695	COG4319	ketosteroid isomerase
HW07_RS13700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW07_RS13705	COG3591	Belongs to the peptidase S1B family
HW07_RS13705	COG1864	DNA RNA non-specific endonuclease
HW07_RS13710	COG0583	DNA-binding transcription factor activity
HW07_RS13720	COG0300	oxidoreductase activity
HW07_RS13725	COG1253	flavin adenine dinucleotide binding
HW07_RS13740	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS13765	COG1126	abc transporter atp-binding protein
HW07_RS13770	COG0765	amino acid transport
HW07_RS13775	COG0765	amino acid transport
HW07_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS13795	COG0189	ligase activity
HW07_RS13800	COG1982	Orn Lys Arg decarboxylase major
HW07_RS13805	COG2197	response regulator
HW07_RS13815	COG3795	YCII-related domain
HW07_RS13825	COG4941	Belongs to the sigma-70 factor family
HW07_RS13830	COG2814	Major facilitator Superfamily
HW07_RS13840	COG3795	YCII-related domain
HW07_RS13855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW07_RS13870	COG5006	permease, DMT superfamily
HW07_RS13900	COG0384	phenazine biosynthesis protein PhzF
HW07_RS13905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW07_RS13925	COG1247	-acetyltransferase
HW07_RS13935	COG4221	oxidoreductase activity
HW07_RS13940	COG2207	Transcriptional regulator
HW07_RS14000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW07_RS14025	COG0210	DNA helicase
HW07_RS14035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW07_RS14035	COG0116	Belongs to the methyltransferase superfamily
HW07_RS14040	COG1196	nuclear chromosome segregation
HW07_RS14040	COG3264	Mechanosensitive ion channel
HW07_RS14050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW07_RS14065	COG0583	DNA-binding transcription factor activity
HW07_RS14070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW07_RS14125	COG0488	(ABC) transporter
HW07_RS14160	COG5001	Diguanylate cyclase
HW07_RS14160	COG3300	MHYT domain
HW07_RS14170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS14175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS14190	COG2832	Protein of unknown function (DUF454)
HW07_RS14230	COG1987	bacterial-type flagellum assembly
HW07_RS14250	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW07_RS14255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW07_RS14285	COG2198	Histidine kinase
HW07_RS14285	COG0784	Response regulator, receiver
HW07_RS14285	COG0643	Histidine kinase
HW07_RS14295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW07_RS14300	COG1360	Flagellar Motor Protein
HW07_RS14305	COG1192	Involved in chromosome partitioning
HW07_RS14315	COG0835	chemotaxis
HW07_RS14340	COG1496	oxidoreductase activity
HW07_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS14360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW07_RS14435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HW07_RS14440	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW07_RS14455	COG3192	ethanolamine utilization protein
HW07_RS14465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HW07_RS14480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW07_RS14485	COG4413	Urea transporter
HW07_RS14490	COG0469	pyruvate kinase activity
HW07_RS14500	COG2084	Dehydrogenase
HW07_RS14505	COG3622	Belongs to the hyi family
HW07_RS14510	COG3960	tartronate-semialdehyde synthase activity
HW07_RS14520	COG1309	transcriptional regulator
HW07_RS14535	COG2233	PERMEase
HW07_RS14595	COG2252	PERMEase
HW07_RS14605	COG0402	S-adenosylhomocysteine deaminase activity
HW07_RS14635	COG1196	nuclear chromosome segregation
HW07_RS14670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW07_RS14685	COG1960	acyl-CoA dehydrogenase activity
HW07_RS14715	COG2076	Multidrug Resistance protein
HW07_RS14755	COG2217	Heavy metal translocating P-type atpase
HW07_RS14765	COG0348	domain, Protein
HW07_RS14770	COG2010	Cytochrome c
HW07_RS14785	COG3278	Belongs to the heme-copper respiratory oxidase family
HW07_RS14790	COG2010	Cytochrome c
HW07_RS14805	COG3278	Belongs to the heme-copper respiratory oxidase family
HW07_RS14820	COG0840	transmembrane signaling receptor activity
HW07_RS14840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS14845	COG0174	glutamine synthetase
HW07_RS14850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS14855	COG0251	oxidation-reduction process
HW07_RS14880	COG3738	Protein conserved in bacteria
HW07_RS14895	COG2084	Dehydrogenase
HW07_RS14925	COG2009	succinate dehydrogenase
HW07_RS14930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HW07_RS14935	COG1053	succinate dehydrogenase
HW07_RS14940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW07_RS15015	COG2207	Transcriptional regulator
HW07_RS15020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW07_RS15020	COG2010	Cytochrome c
HW07_RS15025	COG2010	Cytochrome c
HW07_RS15025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW07_RS15030	COG2080	2 iron, 2 sulfur cluster binding
HW07_RS15035	COG1846	Transcriptional regulator
HW07_RS15075	COG0784	Response regulator, receiver
HW07_RS15075	COG2205	protein histidine kinase activity
HW07_RS15075	COG5002	protein histidine kinase activity
HW07_RS15105	COG1022	Amp-dependent synthetase and ligase
HW07_RS15135	COG0625	glutathione transferase activity
HW07_RS15145	COG0628	permease
HW07_RS15150	COG2807	transmembrane transport
HW07_RS15155	COG2186	Transcriptional regulator
HW07_RS15160	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW07_RS15165	COG1024	Enoyl-CoA hydratase
HW07_RS15175	COG1960	acyl-CoA dehydrogenase activity
HW07_RS15200	COG2205	protein histidine kinase activity
HW07_RS15205	COG0745	RESPONSE REGULATOR receiver
HW07_RS15245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW07_RS15255	COG0840	transmembrane signaling receptor activity
HW07_RS15265	COG2130	NADP-dependent
HW07_RS15280	COG3135	benzoate transporter
HW07_RS15295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW07_RS15300	COG0625	glutathione transferase activity
HW07_RS15340	COG2204	response regulator
HW07_RS15380	COG0515	serine threonine protein kinase
HW07_RS15380	COG2815	serine threonine protein kinase
HW07_RS15400	COG2840	Smr protein MutS2
HW07_RS15480	COG4792	protein secretion
HW07_RS15485	COG4791	protein targeting
HW07_RS15490	COG4794	Type iii secretion
HW07_RS15495	COG4790	Type iii secretion
HW07_RS15545	COG4789	Type iii secretion
HW07_RS15655	COG1317	bacterial-type flagellum organization
HW07_RS15675	COG0505	Belongs to the CarA family
HW07_RS15680	COG2308	Evidence 4 Homologs of previously reported genes of
HW07_RS15690	COG1305	Transglutaminase-like
HW07_RS15710	COG0183	Belongs to the thiolase family
HW07_RS15725	COG0667	Aldo Keto reductase
HW07_RS15740	COG0519	Catalyzes the synthesis of GMP from XMP
HW07_RS15795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW07_RS15830	COG2909	trisaccharide binding
HW07_RS15835	COG2909	trisaccharide binding
HW07_RS15875	COG0189	ligase activity
HW07_RS15875	COG4067	protein conserved in archaea
HW07_RS15915	COG0668	transmembrane transport
HW07_RS15935	COG0243	molybdopterin cofactor binding
HW07_RS15940	COG2146	nitrite reductase [NAD(P)H] activity
HW07_RS15945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW07_RS15950	COG0515	serine threonine protein kinase
HW07_RS15955	COG2223	nitrite transmembrane transporter activity
HW07_RS15965	COG2201	protein-glutamate methylesterase activity
HW07_RS15985	COG0589	response to stress
HW07_RS16005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW07_RS16050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW07_RS16055	COG2205	protein histidine kinase activity
HW07_RS16060	COG0745	RESPONSE REGULATOR receiver
HW07_RS16080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW07_RS16095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW07_RS16105	COG4172	Belongs to the ABC transporter superfamily
HW07_RS16110	COG4239	(ABC) transporter, permease
HW07_RS16115	COG4174	ABC transporter (Permease)
HW07_RS16120	COG4166	transmembrane transport
HW07_RS16125	COG4166	transmembrane transport
HW07_RS16130	COG1388	LysM domain
HW07_RS16130	COG0741	lytic transglycosylase activity
HW07_RS16150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW07_RS16165	COG0531	amino acid
HW07_RS16175	COG1024	Enoyl-CoA hydratase
HW07_RS16200	COG0583	DNA-binding transcription factor activity
HW07_RS16205	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS16210	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS16230	COG0616	signal peptide processing
HW07_RS16235	COG0604	alcohol dehydrogenase
HW07_RS16260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW07_RS16325	COG3813	Protein conserved in bacteria
HW07_RS16330	COG4977	sequence-specific DNA binding
HW07_RS16335	COG4251	negative regulation of phosphorylation
HW07_RS16335	COG3706	GGDEF domain
HW07_RS16335	COG2203	Gaf domain
HW07_RS16335	COG5001	Diguanylate cyclase
HW07_RS16350	COG2239	Acts as a magnesium transporter
HW07_RS16360	COG3278	Belongs to the heme-copper respiratory oxidase family
HW07_RS16365	COG2354	Protein conserved in bacteria
HW07_RS16375	COG0583	DNA-binding transcription factor activity
HW07_RS16380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HW07_RS16400	COG1309	transcriptional regulator
HW07_RS16470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS16515	COG0417	DNA replication proofreading
HW07_RS16540	COG0625	glutathione transferase activity
HW07_RS16555	COG2366	antibiotic biosynthetic process
HW07_RS16580	COG2197	response regulator
HW07_RS16630	COG2814	Major facilitator Superfamily
HW07_RS16650	COG3712	iron ion homeostasis
HW07_RS16655	COG1595	DNA-templated transcription, initiation
HW07_RS16685	COG0579	oxidoreductase
HW07_RS16700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW07_RS16700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW07_RS16705	COG0275	rRNA processing
HW07_RS16710	COG4771	TonB-dependent receptor
HW07_RS16730	COG1944	ATP diphosphatase activity
HW07_RS16790	COG0753	catalase activity
HW07_RS16795	COG2010	Cytochrome c
HW07_RS16820	COG1129	ABC transporter
HW07_RS16825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW07_RS16830	COG1609	Transcriptional regulator
HW07_RS16835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW07_RS16885	COG1278	Cold shock
HW07_RS16890	COG0583	DNA-binding transcription factor activity
HW07_RS16905	COG0488	(ABC) transporter
HW07_RS16950	COG2194	sulfuric ester hydrolase activity
HW07_RS16970	COG2205	protein histidine kinase activity
HW07_RS16970	COG0784	Response regulator, receiver
HW07_RS16985	COG3851	Histidine kinase
HW07_RS17050	COG2205	protein histidine kinase activity
HW07_RS17070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW07_RS17075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW07_RS17080	COG0583	DNA-binding transcription factor activity
HW07_RS17085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW07_RS17100	COG2031	fatty acid transporter
HW07_RS17105	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS17110	COG2610	gluconate transmembrane transporter activity
HW07_RS17115	COG3829	transcription factor binding
HW07_RS17115	COG3290	protein histidine kinase activity
HW07_RS17130	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW07_RS17160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW07_RS17165	COG1960	acyl-CoA dehydrogenase activity
HW07_RS17170	COG0789	Transcriptional regulator
HW07_RS17175	COG3204	pilus organization
HW07_RS17185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS17190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS17195	COG1309	transcriptional regulator
HW07_RS17235	COG1522	sequence-specific DNA binding
HW07_RS17260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW07_RS17275	COG0028	Belongs to the TPP enzyme family
HW07_RS17290	COG0174	glutamine synthetase
HW07_RS17295	COG0531	amino acid
HW07_RS17305	COG0564	pseudouridine synthase activity
HW07_RS17325	COG2207	Transcriptional regulator
HW07_RS17340	COG1595	DNA-templated transcription, initiation
HW07_RS17360	COG0583	DNA-binding transcription factor activity
HW07_RS17375	COG4771	TonB-dependent receptor
HW07_RS17385	COG4174	ABC transporter (Permease)
HW07_RS17390	COG4239	(ABC) transporter, permease
HW07_RS17395	COG4172	Belongs to the ABC transporter superfamily
HW07_RS17400	COG1104	cysteine desulfurase activity
HW07_RS17430	COG2814	Major facilitator Superfamily
HW07_RS17435	COG2192	nodulation
HW07_RS17440	COG4206	TonB-dependent receptor
HW07_RS17450	COG5001	Diguanylate cyclase
HW07_RS17470	COG2010	Cytochrome c
HW07_RS17475	COG2010	Cytochrome c
HW07_RS17480	COG1113	amino acid transport
HW07_RS17495	COG1522	sequence-specific DNA binding
HW07_RS17505	COG0367	asparagine synthase
HW07_RS17510	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HW07_RS17515	COG0596	Alpha beta hydrolase
HW07_RS17535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW07_RS17545	COG2814	Major facilitator Superfamily
HW07_RS17580	COG0300	oxidoreductase activity
HW07_RS17585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW07_RS17605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW07_RS17610	COG1045	serine acetyltransferase
HW07_RS17615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW07_RS17625	COG0028	Belongs to the TPP enzyme family
HW07_RS17635	COG1984	allophanate hydrolase subunit 2
HW07_RS17655	COG2814	Major facilitator Superfamily
HW07_RS17660	COG0583	DNA-binding transcription factor activity
HW07_RS17675	COG2169	Transcriptional regulator
HW07_RS17675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW07_RS17685	COG1063	alcohol dehydrogenase
HW07_RS17705	COG0583	DNA-binding transcription factor activity
HW07_RS17720	COG1475	DNA binding
HW07_RS17730	COG3969	phosphoadenosine phosphosulfate
HW07_RS17740	COG3121	Chaperone
HW07_RS17745	COG3188	usher protein
HW07_RS17755	COG3121	Chaperone
HW07_RS17775	COG2323	membrane
HW07_RS17805	COG1546	Belongs to the CinA family
HW07_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS17825	COG0058	SHG alpha-glucan phosphorylase activity
HW07_RS17845	COG1285	pathogenesis
HW07_RS17865	COG0366	Alpha amylase catalytic
HW07_RS17875	COG0392	lysyltransferase activity
HW07_RS17880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW07_RS17885	COG3568	Endonuclease Exonuclease Phosphatase
HW07_RS17925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HW07_RS17965	COG1363	Peptidase, m42
HW07_RS17995	COG4191	Histidine kinase
HW07_RS17995	COG0784	Response regulator, receiver
HW07_RS18010	COG2890	protein-(glutamine-N5) methyltransferase activity
HW07_RS18035	COG3685	Protein conserved in bacteria
HW07_RS18040	COG3546	catalase activity
HW07_RS18055	COG1063	alcohol dehydrogenase
HW07_RS18075	COG0517	IMP dehydrogenase activity
HW07_RS18095	COG1309	transcriptional regulator
HW07_RS18100	COG2130	NADP-dependent
HW07_RS18110	COG2084	Dehydrogenase
HW07_RS18125	COG0765	amino acid transport
HW07_RS18130	COG0765	amino acid transport
HW07_RS18165	COG2271	Major facilitator Superfamily
HW07_RS18170	COG3618	amidohydrolase
HW07_RS18185	COG2271	Major facilitator Superfamily
HW07_RS18190	COG4948	Mandelate Racemase Muconate Lactonizing
HW07_RS18200	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS18205	COG2995	paraquat-inducible protein a
HW07_RS18210	COG3008	intermembrane lipid transfer
HW07_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS18245	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS18250	COG3162	membrane
HW07_RS18255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW07_RS18270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW07_RS18275	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS18280	COG0531	amino acid
HW07_RS18295	COG2072	flavoprotein involved in K transport
HW07_RS18310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS18330	COG2409	Drug exporters of the RND superfamily
HW07_RS18335	COG4447	cellulose binding
HW07_RS18345	COG2508	Transcriptional regulator
HW07_RS18355	COG2801	Transposase and inactivated derivatives
HW07_RS18360	COG2963	transposase activity
HW07_RS18385	COG2258	MOSC domain
HW07_RS18445	COG0728	peptidoglycan biosynthetic process
HW07_RS18455	COG1053	succinate dehydrogenase
HW07_RS18500	COG1115	amino acid carrier protein
HW07_RS18505	COG0252	asparaginase activity
HW07_RS18535	COG1609	Transcriptional regulator
HW07_RS18545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW07_RS18580	COG2329	Antibiotic biosynthesis monooxygenase
HW07_RS18590	COG1309	transcriptional regulator
HW07_RS18615	COG1064	alcohol dehydrogenase
HW07_RS18620	COG2207	Transcriptional regulator
HW07_RS18625	COG0640	Transcriptional regulator
HW07_RS18635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW07_RS18640	COG0431	NADPH-dependent FMN reductase
HW07_RS18685	COG4772	TonB-dependent receptor
HW07_RS18715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW07_RS18730	COG1053	succinate dehydrogenase
HW07_RS18735	COG2188	Transcriptional regulator
HW07_RS18740	COG3469	chitinase activity
HW07_RS18750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW07_RS18750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW07_RS18780	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HW07_RS18790	COG2175	clavaminate synthase activity
HW07_RS18800	COG1396	sequence-specific DNA binding
HW07_RS18820	COG0583	DNA-binding transcription factor activity
HW07_RS18825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS18835	COG1609	Transcriptional regulator
HW07_RS18840	COG3265	gluconokinase activity
HW07_RS18850	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS18870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW07_RS18875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS18880	COG1116	anion transmembrane transporter activity
HW07_RS18895	COG4977	sequence-specific DNA binding
HW07_RS18895	COG1917	Cupin 2, conserved barrel domain protein
HW07_RS18910	COG4771	TonB-dependent receptor
HW07_RS18930	COG1175	transmembrane transport
HW07_RS18945	COG0246	Mannitol dehydrogenase
HW07_RS18950	COG1070	Carbohydrate kinase
HW07_RS18955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW07_RS18980	COG1464	Belongs to the NlpA lipoprotein family
HW07_RS18990	COG2011	ABC-type metal ion transport system permease component
HW07_RS18995	COG0584	glycerophosphoryl diester phosphodiesterase
HW07_RS19000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW07_RS19005	COG3829	transcription factor binding
HW07_RS19030	COG3829	transcription factor binding
HW07_RS19120	COG2197	response regulator
HW07_RS19150	COG1304	FMN binding
HW07_RS19160	COG0735	belongs to the Fur family
HW07_RS19185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS19275	COG1121	(ABC) transporter
HW07_RS19280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW07_RS19320	COG0583	DNA-binding transcription factor activity
HW07_RS19330	COG1335	isochorismatase
HW07_RS19390	COG1566	PFAM secretion protein HlyD family protein
HW07_RS19405	COG0583	DNA-binding transcription factor activity
HW07_RS19420	COG2217	Heavy metal translocating P-type atpase
HW07_RS19455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW07_RS19460	COG1760	l-serine dehydratase
HW07_RS19480	COG0583	DNA-binding transcription factor activity
HW07_RS19500	COG2382	esterase
HW07_RS19510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW07_RS19550	COG3712	iron ion homeostasis
HW07_RS19555	COG1595	DNA-templated transcription, initiation
HW07_RS19560	COG0583	DNA-binding transcription factor activity
HW07_RS19580	COG0625	glutathione transferase activity
HW07_RS19615	COG0642	Histidine kinase
HW07_RS19620	COG3258	Cytochrome c
HW07_RS19625	COG2863	cytochrome
HW07_RS19630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW07_RS19690	COG2318	DinB family
HW07_RS19705	COG0590	tRNA wobble adenosine to inosine editing
HW07_RS19710	COG2807	transmembrane transport
HW07_RS19745	COG3485	protocatechuate 3,4-dioxygenase
HW07_RS19755	COG4948	Mandelate Racemase Muconate Lactonizing
HW07_RS19770	COG4638	Rieske (2fe-2S)
HW07_RS19775	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HW07_RS19780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW07_RS19780	COG0543	2 iron, 2 sulfur cluster binding
HW07_RS19840	COG1538	Outer membrane efflux protein
HW07_RS19845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS19850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS19870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW07_RS19880	COG1115	amino acid carrier protein
HW07_RS19890	COG0667	Aldo Keto reductase
HW07_RS19895	COG4589	Belongs to the CDS family
HW07_RS19910	COG2453	phosphatase
HW07_RS19910	COG0671	phosphoesterase, PA-phosphatase related
HW07_RS19915	COG2267	carboxylic ester hydrolase activity
HW07_RS19920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW07_RS19930	COG0729	surface antigen
HW07_RS19980	COG1960	acyl-CoA dehydrogenase activity
HW07_RS19985	COG0183	Belongs to the thiolase family
HW07_RS19995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW07_RS20005	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS20040	COG0659	secondary active sulfate transmembrane transporter activity
HW07_RS20050	COG2203	Gaf domain
HW07_RS20050	COG5001	Diguanylate cyclase
HW07_RS20050	COG3706	GGDEF domain
HW07_RS20050	COG4251	negative regulation of phosphorylation
HW07_RS20075	COG2135	peptidase activity
HW07_RS20095	COG3179	chitinase
HW07_RS20215	COG5484	DNA packaging
HW07_RS20215	COG3728	DNA packaging
HW07_RS20285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW07_RS20305	COG3723	Recombinational DNA repair protein, rece pathway
HW07_RS20315	COG1674	ftsk spoiiie
HW07_RS20320	COG0419	ATPase involved in DNA repair
HW07_RS20370	COG4191	Histidine kinase
HW07_RS20400	COG1522	sequence-specific DNA binding
HW07_RS20415	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW07_RS20435	COG0784	Response regulator, receiver
HW07_RS20435	COG2198	Histidine kinase
HW07_RS20435	COG2205	protein histidine kinase activity
HW07_RS20435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS20480	COG4771	TonB-dependent receptor
HW07_RS20485	COG2197	response regulator
HW07_RS20510	COG0842	Transport permease protein
HW07_RS20515	COG0842	Transport permease protein
HW07_RS20520	COG1131	(ABC) transporter
HW07_RS20530	COG1309	transcriptional regulator
HW07_RS20540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW07_RS20545	COG1960	acyl-CoA dehydrogenase activity
HW07_RS20585	COG3424	synthase
HW07_RS20590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS20600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS20605	COG1960	acyl-CoA dehydrogenase activity
HW07_RS20615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS20620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW07_RS20625	COG0583	DNA-binding transcription factor activity
HW07_RS20665	COG2920	part of a sulfur-relay system
HW07_RS20670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW07_RS20675	COG0435	Glutathione S-transferase
HW07_RS20690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW07_RS20705	COG0492	ferredoxin-NADP+ reductase activity
HW07_RS20720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW07_RS20725	COG0542	response to heat
HW07_RS20735	COG1278	Cold shock
HW07_RS20775	COG2850	peptidyl-arginine hydroxylation
HW07_RS20780	COG2153	protein acetylation
HW07_RS20875	COG2226	methyltransferase
HW07_RS20890	COG2056	Na+-H+ antiporter family
HW07_RS20895	COG0840	transmembrane signaling receptor activity
HW07_RS20950	COG3604	Transcriptional regulator
HW07_RS20955	COG0720	synthase
HW07_RS20995	COG2165	general secretion pathway protein
HW07_RS21005	COG1459	type II secretion system
HW07_RS21010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW07_RS21020	COG4106	trans-aconitate 2-methyltransferase activity
HW07_RS21030	COG0583	DNA-binding transcription factor activity
HW07_RS21075	COG2819	hydrolase of the alpha beta superfamily
HW07_RS21085	COG1959	2 iron, 2 sulfur cluster binding
HW07_RS21090	COG1607	acyl-coa hydrolase
HW07_RS21160	COG0542	response to heat
HW07_RS21175	COG1280	lysine exporter protein (LysE YggA)
HW07_RS21195	COG0243	molybdopterin cofactor binding
HW07_RS21200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW07_RS21205	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS21205	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW07_RS21215	COG0789	Transcriptional regulator
HW07_RS21250	COG0542	response to heat
HW07_RS21260	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW07_RS21260	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW07_RS21295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW07_RS21310	COG2801	Transposase and inactivated derivatives
HW07_RS21315	COG2963	transposase activity
HW07_RS21395	COG0024	Methionine aminopeptidase
HW07_RS21425	COG1295	ribonuclease BN
HW07_RS21435	COG1238	metal cluster binding
HW07_RS21520	COG2837	iron assimilation
HW07_RS21530	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW07_RS21530	COG1024	Enoyl-CoA hydratase
HW07_RS21540	COG1051	belongs to the nudix hydrolase family
HW07_RS21595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW07_RS21600	COG2116	formate transmembrane transporter activity
HW07_RS21640	COG3655	Transcriptional regulator
HW07_RS21695	COG1335	isochorismatase
HW07_RS21715	COG0745	RESPONSE REGULATOR receiver
HW07_RS21725	COG2853	Lipoprotein
HW07_RS21735	COG2188	Transcriptional regulator
HW07_RS21780	COG0842	Transport permease protein
HW07_RS21785	COG1131	(ABC) transporter
HW07_RS21790	COG0625	glutathione transferase activity
HW07_RS21880	COG0625	glutathione transferase activity
HW07_RS21885	COG1956	GAF domain-containing protein
HW07_RS21890	COG2255	four-way junction helicase activity
HW07_RS21895	COG5002	protein histidine kinase activity
HW07_RS21895	COG0784	Response regulator, receiver
HW07_RS21895	COG2205	protein histidine kinase activity
HW07_RS21900	COG1846	Transcriptional regulator
HW07_RS21905	COG0386	Belongs to the glutathione peroxidase family
HW07_RS21915	COG0436	Aminotransferase
HW07_RS21930	COG2866	Carboxypeptidase
HW07_RS21970	COG3384	dioxygenase
HW07_RS21980	COG1024	Enoyl-CoA hydratase
HW07_RS21990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HW07_RS21995	COG3214	Protein conserved in bacteria
HW07_RS22005	COG0583	DNA-binding transcription factor activity
HW07_RS22015	COG0583	DNA-binding transcription factor activity
HW07_RS22020	COG1846	Transcriptional regulator
HW07_RS22025	COG1764	response to oxidative stress
HW07_RS22065	COG4181	ATPase activity
HW07_RS22070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HW07_RS22085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW07_RS22100	COG2259	Doxx family
HW07_RS22105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW07_RS22110	COG0084	hydrolase, TatD family'
HW07_RS22155	COG0714	Associated with various cellular activities
HW07_RS22165	COG0583	DNA-binding transcription factor activity
HW07_RS22175	COG0583	DNA-binding transcription factor activity
HW07_RS22205	COG1309	transcriptional regulator
HW07_RS22220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW07_RS22225	COG1960	acyl-CoA dehydrogenase activity
HW07_RS22230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW07_RS22245	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS22260	COG1595	DNA-templated transcription, initiation
HW07_RS22265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW07_RS22275	COG2197	response regulator
HW07_RS22280	COG2885	chlorophyll binding
HW07_RS22280	COG3047	cAMP biosynthetic process
HW07_RS22310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW07_RS22340	COG1120	ATPase activity
HW07_RS22350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW07_RS22380	COG0840	transmembrane signaling receptor activity
HW07_RS22385	COG0583	DNA-binding transcription factor activity
HW07_RS22390	COG1473	amidohydrolase
HW07_RS22395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS22400	COG4215	(ABC) transporter
HW07_RS22405	COG4160	amino acid transport
HW07_RS22440	COG1309	transcriptional regulator
HW07_RS22445	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS22450	COG2814	Major facilitator Superfamily
HW07_RS22470	COG3038	cytochrome b561
HW07_RS22480	COG2233	PERMEase
HW07_RS22490	COG0183	Belongs to the thiolase family
HW07_RS22505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW07_RS22590	COG0084	hydrolase, TatD family'
HW07_RS22610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW07_RS22620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW07_RS22650	COG1399	metal-binding, possibly nucleic acid-binding protein
HW07_RS22660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW07_RS22660	COG0616	signal peptide processing
HW07_RS22665	COG0546	phosphoglycolate phosphatase activity
HW07_RS22675	COG1530	ribonuclease E activity
HW07_RS22685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW07_RS22705	COG0848	biopolymer transport protein
HW07_RS22710	COG0811	peptide transport
HW07_RS22715	COG2333	competence protein COMEC
HW07_RS22715	COG0658	competence protein
HW07_RS22735	COG4591	ABC-type transport system involved in lipoprotein release permease component
HW07_RS22750	COG0584	glycerophosphoryl diester phosphodiesterase
HW07_RS22765	COG1477	protein flavinylation
HW07_RS22800	COG1113	amino acid transport
HW07_RS22810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW07_RS22885	COG0589	response to stress
HW07_RS22895	COG0488	(ABC) transporter
HW07_RS22900	COG0741	lytic transglycosylase activity
HW07_RS22920	COG1070	Carbohydrate kinase
HW07_RS22925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW07_RS22945	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW07_RS22975	COG1309	transcriptional regulator
HW07_RS22980	COG0625	glutathione transferase activity
HW07_RS22990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW07_RS23000	COG0004	ammonium transporteR
HW07_RS23025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS23025	COG2205	protein histidine kinase activity
HW07_RS23030	COG2197	response regulator
HW07_RS23035	COG3171	Protein conserved in bacteria
HW07_RS23040	COG2027	D-alanyl-D-alanine carboxypeptidase
HW07_RS23050	COG3130	regulation of translation
HW07_RS23100	COG0297	glycogen (starch) synthase activity
HW07_RS23125	COG2342	PFAM TM1410 hypothetical-related protein
HW07_RS23135	COG1335	isochorismatase
HW07_RS23155	COG0714	Associated with various cellular activities
HW07_RS23190	COG0745	RESPONSE REGULATOR receiver
HW07_RS23220	COG0308	aminopeptidase N
HW07_RS23230	COG3139	Protein of unknown function (DUF1315)
HW07_RS23240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW07_RS23265	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW07_RS23265	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS23365	COG1286	toxin biosynthetic process
HW07_RS23370	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW07_RS23375	COG0285	dihydrofolate synthase activity
HW07_RS23415	COG2226	methyltransferase
HW07_RS23435	COG0251	oxidation-reduction process
HW07_RS23440	COG0583	DNA-binding transcription factor activity
HW07_RS23460	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS23475	COG0800	Aldolase
HW07_RS23480	COG0596	Alpha beta hydrolase
HW07_RS23515	COG0583	DNA-binding transcription factor activity
HW07_RS23555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW07_RS23620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW07_RS23650	COG0402	S-adenosylhomocysteine deaminase activity
HW07_RS23665	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS23680	COG0786	glutamate:sodium symporter activity
HW07_RS23725	COG0676	glucose-6-phosphate 1-epimerase activity
HW07_RS23735	COG3842	ATPase activity
HW07_RS23740	COG0395	ABC-type sugar transport system, permease component
HW07_RS23745	COG1175	transmembrane transport
HW07_RS23790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW07_RS23800	COG0009	L-threonylcarbamoyladenylate synthase
HW07_RS23805	COG0613	PHP domain protein
HW07_RS23815	COG2350	Protein conserved in bacteria
HW07_RS23825	COG0745	RESPONSE REGULATOR receiver
HW07_RS23845	COG0778	Nitroreductase
HW07_RS23850	COG0727	PFAM Uncharacterised protein family (UPF0153)
HW07_RS23855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW07_RS23860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW07_RS23865	COG1127	ABC transporter
HW07_RS23895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW07_RS23895	COG0438	transferase activity, transferring glycosyl groups
HW07_RS23910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW07_RS23945	COG1132	(ABC) transporter
HW07_RS23975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW07_RS23980	COG3162	membrane
HW07_RS24000	COG2853	Lipoprotein
HW07_RS24015	COG1560	Kdo2-lipid A biosynthetic process
HW07_RS24025	COG2894	cell division
HW07_RS24035	COG0564	pseudouridine synthase activity
HW07_RS24065	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW07_RS24080	COG0560	Phosphoserine phosphatase
HW07_RS24085	COG3321	synthase
HW07_RS24085	COG0604	alcohol dehydrogenase
HW07_RS24095	COG2200	EAL domain
HW07_RS24145	COG0385	Bile acid
HW07_RS24150	COG2076	Multidrug Resistance protein
HW07_RS24165	COG4772	TonB-dependent receptor
HW07_RS24180	COG2205	protein histidine kinase activity
HW07_RS24185	COG1201	RNA secondary structure unwinding
HW07_RS24255	COG1595	DNA-templated transcription, initiation
HW07_RS24305	COG0537	adenosine 5'-monophosphoramidase activity
HW07_RS24315	COG1643	Atp-dependent helicase
HW07_RS24325	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS24330	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS24335	COG2267	carboxylic ester hydrolase activity
HW07_RS24340	COG2030	dehydratase
HW07_RS24345	COG2814	Major facilitator Superfamily
HW07_RS24385	COG0589	response to stress
HW07_RS24400	COG2084	Dehydrogenase
HW07_RS24405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW07_RS24415	COG3639	organic phosphonate transmembrane transporter activity
HW07_RS24445	COG0583	DNA-binding transcription factor activity
HW07_RS24490	COG4221	oxidoreductase activity
HW07_RS24495	COG2124	cytochrome p450
HW07_RS24535	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW07_RS24555	COG5001	Diguanylate cyclase
HW07_RS24555	COG2203	Gaf domain
HW07_RS24555	COG3706	GGDEF domain
HW07_RS24555	COG4251	negative regulation of phosphorylation
HW07_RS24560	COG0514	ATP-dependent DNA helicase (RecQ)
HW07_RS24570	COG0745	RESPONSE REGULATOR receiver
HW07_RS24585	COG0784	Response regulator, receiver
HW07_RS24585	COG0835	chemotaxis
HW07_RS24605	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HW07_RS24630	COG0697	spore germination
HW07_RS24705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW07_RS24715	COG3454	Phosphonate metabolism
HW07_RS24720	COG4778	phosphonate C-P lyase system protein PhnL
HW07_RS24725	COG4107	phosphonate C-P lyase system protein PhnK
HW07_RS24730	COG3627	carbon phosphorus lyase activity
HW07_RS24735	COG3626	phosphonate metabolism
HW07_RS24745	COG3624	Phosphonate C-P lyase system protein PhnG
HW07_RS24750	COG2188	Transcriptional regulator
HW07_RS24755	COG3639	organic phosphonate transmembrane transporter activity
HW07_RS24760	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW07_RS24835	COG0583	DNA-binding transcription factor activity
HW07_RS24890	COG1629	transport
HW07_RS24930	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW07_RS24975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW07_RS24985	COG1024	Enoyl-CoA hydratase
HW07_RS24990	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS25010	COG1346	cytolysis
HW07_RS25015	COG1380	Effector of murein hydrolase LrgA
HW07_RS25020	COG0583	DNA-binding transcription factor activity
HW07_RS25045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW07_RS25070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW07_RS25080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS25085	COG0431	NADPH-dependent FMN reductase
HW07_RS25095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW07_RS25100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW07_RS25105	COG0450	alkyl hydroperoxide reductase
HW07_RS25125	COG0183	Belongs to the thiolase family
HW07_RS25150	COG0367	asparagine synthase
HW07_RS25155	COG0189	ligase activity
HW07_RS25155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW07_RS25160	COG1363	Peptidase, m42
HW07_RS25165	COG5002	protein histidine kinase activity
HW07_RS25165	COG2205	protein histidine kinase activity
HW07_RS25165	COG0784	Response regulator, receiver
HW07_RS25185	COG0513	Belongs to the DEAD box helicase family
HW07_RS25190	COG0477	Major facilitator Superfamily
HW07_RS25195	COG0668	transmembrane transport
HW07_RS25200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW07_RS25215	COG0791	NLP P60 protein
HW07_RS25260	COG0489	protein tyrosine kinase activity
HW07_RS25315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW07_RS25325	COG2264	protein methyltransferase activity
HW07_RS25330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW07_RS25365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS25395	COG0450	alkyl hydroperoxide reductase
HW07_RS25410	COG2223	nitrite transmembrane transporter activity
HW07_RS25415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HW07_RS25420	COG0243	molybdopterin cofactor binding
HW07_RS25440	COG3842	ATPase activity
HW07_RS25550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW07_RS25550	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HW07_RS25550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW07_RS25555	COG1105	Belongs to the carbohydrate kinase PfkB family
HW07_RS25565	COG1609	Transcriptional regulator
HW07_RS25570	COG0084	hydrolase, TatD family'
HW07_RS25580	COG0583	DNA-binding transcription factor activity
HW07_RS25620	COG2814	Major facilitator Superfamily
HW07_RS25660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW07_RS25695	COG0583	DNA-binding transcription factor activity
HW07_RS25705	COG0183	Belongs to the thiolase family
HW07_RS25710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW07_RS25715	COG1024	Enoyl-CoA hydratase
HW07_RS25720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW07_RS25725	COG1960	acyl-CoA dehydrogenase activity
HW07_RS25730	COG0583	DNA-binding transcription factor activity
HW07_RS25735	COG0477	Major facilitator Superfamily
HW07_RS25740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW07_RS25740	COG2169	Transcriptional regulator
HW07_RS25745	COG0531	amino acid
HW07_RS25770	COG0069	glutamate synthase activity
HW07_RS25790	COG3148	PFAM DTW domain containing protein
HW07_RS25800	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW07_RS25805	COG1177	transmembrane transport
HW07_RS25820	COG3530	Putative quorum-sensing-regulated virulence factor
HW07_RS25825	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HW07_RS25830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW07_RS25850	COG1546	Belongs to the CinA family
HW07_RS25900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HW07_RS25905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HW07_RS25910	COG0583	DNA-binding transcription factor activity
HW07_RS25915	COG2391	methyltransferase activity
HW07_RS25965	COG1115	amino acid carrier protein
HW07_RS26045	COG0024	Methionine aminopeptidase
HW07_RS26055	COG0436	Aminotransferase
HW07_RS26060	COG0025	NhaP-type Na H and K H
HW07_RS26080	COG1393	Belongs to the ArsC family
HW07_RS26100	COG2166	iron-sulfur cluster assembly
HW07_RS26145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS26170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HW07_RS26175	COG1801	Protein of unknown function DUF72
HW07_RS26185	COG1214	PFAM Peptidase M22, glycoprotease
HW07_RS26205	COG0789	Transcriptional regulator
HW07_RS26220	COG2885	chlorophyll binding
HW07_RS26235	COG1073	alpha beta
HW07_RS26235	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HW07_RS26235	COG3064	Membrane
HW07_RS26265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW07_RS26270	COG5001	Diguanylate cyclase
HW07_RS26270	COG2203	Gaf domain
HW07_RS26270	COG4251	negative regulation of phosphorylation
HW07_RS26270	COG3706	GGDEF domain
HW07_RS26305	COG0477	Major facilitator Superfamily
HW07_RS26325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW07_RS26330	COG2197	response regulator
HW07_RS26375	COG1902	pentaerythritol trinitrate reductase activity
HW07_RS26385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW07_RS26400	COG2255	four-way junction helicase activity
HW07_RS26425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW07_RS26450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW07_RS26470	COG1607	acyl-coa hydrolase
HW07_RS26495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW07_RS26505	COG4536	flavin adenine dinucleotide binding
HW07_RS26510	COG0477	Major facilitator Superfamily
HW07_RS26550	COG2188	Transcriptional regulator
HW07_RS26555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW07_RS26560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW07_RS26565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW07_RS26565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW07_RS26600	COG0590	tRNA wobble adenosine to inosine editing
HW07_RS26605	COG2132	Multicopper oxidase
HW07_RS26655	COG0583	DNA-binding transcription factor activity
HW07_RS26660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW07_RS26670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW07_RS26685	COG1335	isochorismatase
HW07_RS26695	COG2847	Copper chaperone PCu(A)C
HW07_RS26705	COG0739	heme binding
HW07_RS26745	COG0667	Aldo Keto reductase
HW07_RS26760	COG0436	Aminotransferase
HW07_RS26850	COG1045	serine acetyltransferase
HW07_RS26865	COG3134	Outer membrane lipoprotein
HW07_RS26880	COG1862	Preprotein translocase
HW07_RS26900	COG2200	EAL domain
HW07_RS26910	COG0795	lipopolysaccharide-transporting ATPase activity
HW07_RS26915	COG0795	lipopolysaccharide-transporting ATPase activity
HW07_RS26960	COG4120	Belongs to the binding-protein-dependent transport system permease family
HW07_RS26965	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HW07_RS26970	COG0490	domain, Protein
HW07_RS26970	COG0471	metal ion transport
HW07_RS27000	COG0583	DNA-binding transcription factor activity
HW07_RS27065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS27075	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS27100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS27110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW07_RS27115	COG2181	nitrate reductase activity
HW07_RS27120	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW07_RS27125	COG1140	nitrate reductase beta subunit
HW07_RS27130	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW07_RS27135	COG2223	nitrite transmembrane transporter activity
HW07_RS27145	COG3850	Histidine kinase
HW07_RS27150	COG2197	response regulator
HW07_RS27165	COG2226	methyltransferase
HW07_RS27170	COG0300	oxidoreductase activity
HW07_RS27220	COG1566	PFAM secretion protein HlyD family protein
HW07_RS27240	COG0583	DNA-binding transcription factor activity
HW07_RS27250	COG0697	spore germination
HW07_RS27260	COG1595	DNA-templated transcription, initiation
HW07_RS27265	COG3712	iron ion homeostasis
HW07_RS27270	COG4772	TonB-dependent receptor
HW07_RS27320	COG3154	lipid carrier protein
HW07_RS27325	COG0826	peptidase U32
HW07_RS27330	COG0826	peptidase U32
HW07_RS27335	COG0303	'Molybdopterin
HW07_RS27340	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW07_RS27350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HW07_RS27360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW07_RS27385	COG0318	PFAM AMP-dependent synthetase and ligase
HW07_RS27390	COG0183	Belongs to the thiolase family
HW07_RS27400	COG2207	Transcriptional regulator
HW07_RS27410	COG1294	oxidase, subunit
HW07_RS27415	COG1271	oxidase subunit
HW07_RS27430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW07_RS27435	COG1297	OPT oligopeptide transporter protein
HW07_RS27440	COG2175	clavaminate synthase activity
HW07_RS27445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW07_RS27455	COG4521	taurine ABC transporter
HW07_RS27475	COG1946	Acyl-CoA thioesterase
HW07_RS27495	COG2205	protein histidine kinase activity
HW07_RS27495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS27500	COG2199	diguanylate cyclase activity
HW07_RS27500	COG2202	Pas domain
HW07_RS27500	COG2200	EAL domain
HW07_RS27505	COG2197	response regulator
HW07_RS27515	COG0513	Belongs to the DEAD box helicase family
HW07_RS27525	COG3416	Protein conserved in bacteria
HW07_RS27570	COG1643	Atp-dependent helicase
HW07_RS27580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW07_RS27620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW07_RS27630	COG1960	acyl-CoA dehydrogenase activity
HW07_RS27640	COG2205	protein histidine kinase activity
HW07_RS27640	COG0784	Response regulator, receiver
HW07_RS27640	COG2198	Histidine kinase
HW07_RS27645	COG0351	phosphomethylpyrimidine kinase
HW07_RS27675	COG1702	phosphate starvation-inducible protein PhoH
HW07_RS27685	COG4535	Mg2 and Co2 transporter CorC
HW07_RS27695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HW07_RS27730	COG2951	lytic endotransglycosylase activity
HW07_RS27760	COG1686	Belongs to the peptidase S11 family
HW07_RS27770	COG2951	lytic endotransglycosylase activity
HW07_RS27775	COG0772	Belongs to the SEDS family
HW07_RS27780	COG0768	penicillin binding
HW07_RS27820	COG0586	Pfam SNARE associated Golgi protein
HW07_RS27830	COG1346	cytolysis
HW07_RS27850	COG0702	epimerase
HW07_RS27865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW07_RS27870	COG3284	Transcriptional regulator
HW07_RS27880	COG0531	amino acid
HW07_RS27885	COG4303	Ethanolamine ammonia lyase large subunit
HW07_RS27895	COG0456	acetyltransferase
HW07_RS27910	COG0586	Pfam SNARE associated Golgi protein
HW07_RS27915	COG3228	Belongs to the MtfA family
HW07_RS27925	COG0745	RESPONSE REGULATOR receiver
HW07_RS27945	COG5002	protein histidine kinase activity
HW07_RS27950	COG1131	(ABC) transporter
HW07_RS27970	COG4948	Mandelate Racemase Muconate Lactonizing
HW07_RS27980	COG0142	geranyltranstransferase activity
HW07_RS28005	COG3577	Aspartyl protease
HW07_RS28015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW07_RS28020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HW07_RS28045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW07_RS28045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW07_RS28060	COG2264	protein methyltransferase activity
HW07_RS28065	COG3118	belongs to the thioredoxin family
HW07_RS28095	COG3047	cAMP biosynthetic process
HW07_RS28105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW07_RS28125	COG0531	amino acid
HW07_RS28165	COG2197	response regulator
HW07_RS28180	COG3121	Chaperone
HW07_RS28185	COG3188	usher protein
HW07_RS28190	COG3121	Chaperone
HW07_RS28205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW07_RS28210	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS28245	COG2271	Major facilitator Superfamily
HW07_RS28250	COG1063	alcohol dehydrogenase
HW07_RS28255	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS28275	COG0583	DNA-binding transcription factor activity
HW07_RS28315	COG1611	Belongs to the LOG family
HW07_RS28355	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS28360	COG3384	dioxygenase
HW07_RS28370	COG2271	Major facilitator Superfamily
HW07_RS28375	COG3971	2-oxopent-4-enoate hydratase activity
HW07_RS28390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW07_RS28400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW07_RS28405	COG3278	Belongs to the heme-copper respiratory oxidase family
HW07_RS28415	COG1846	Transcriptional regulator
HW07_RS28420	COG2814	Major facilitator Superfamily
HW07_RS28450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS28480	COG3284	Transcriptional regulator
HW07_RS28490	COG3199	ATP-NAD kinase
HW07_RS28495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW07_RS28500	COG0022	dehydrogenase e1 component
HW07_RS28510	COG1063	alcohol dehydrogenase
HW07_RS28515	COG4991	sh3 domain protein
HW07_RS28520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW07_RS28525	COG1629	transport
HW07_RS28525	COG4774	siderophore transport
HW07_RS28535	COG1120	ATPase activity
HW07_RS28540	COG4592	Periplasmic binding protein
HW07_RS28545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW07_RS28550	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW07_RS28555	COG1028	Short-chain dehydrogenase reductase Sdr
HW07_RS28560	COG0154	amidase activity
HW07_RS28590	COG1959	2 iron, 2 sulfur cluster binding
HW07_RS28600	COG0693	protein deglycase activity
HW07_RS28610	COG0251	oxidation-reduction process
HW07_RS28625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW07_RS28635	COG2226	methyltransferase
HW07_RS28680	COG2271	Major facilitator Superfamily
HW07_RS28685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW07_RS28690	COG1012	belongs to the aldehyde dehydrogenase family
HW07_RS28710	COG0765	amino acid transport
HW07_RS28715	COG0765	amino acid transport
HW07_RS28720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW07_RS28725	COG4566	intracellular signal transduction
HW07_RS28730	COG4191	Histidine kinase
HW07_RS28740	COG1960	acyl-CoA dehydrogenase activity
HW07_RS28745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW07_RS28765	COG2706	6-phosphogluconolactonase activity
HW07_RS28775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW07_RS28780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW07_RS28865	COG1132	(ABC) transporter
HW07_RS28865	COG2375	cellular response to nickel ion
HW07_RS28875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW07_RS28875	COG2226	methyltransferase
HW07_RS28875	COG3433	isochorismatase activity
HW07_RS28880	COG2226	methyltransferase
HW07_RS28880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW07_RS28880	COG3433	isochorismatase activity
HW07_RS28890	COG1021	2,3-dihydroxybenzoate-AMP ligase
HW07_RS28915	COG2814	Major facilitator Superfamily
HW07_RS29040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome