locus-tag class description HH306_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HH306_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH306_RS00030 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HH306_RS00050 ENOG4108R3E Dna-3-methyladenine glycosylase i HH306_RS00065 ENOG4105EX9 Membrane HH306_RS00075 ENOG4105WAP TPR repeat-containing protein HH306_RS00080 ENOG4105C1A potassium transporter peripheral membrane HH306_RS00085 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HH306_RS00095 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HH306_RS00100 ENOG4108WZM domain protein HH306_RS00105 ENOG4105C79 DNA protecting protein DprA HH306_RS00115 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HH306_RS00120 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HH306_RS00125 ENOG4105E2X shikimate dehydrogenase HH306_RS00135 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase HH306_RS00155 ENOG4105CBG Sulfatase HH306_RS00160 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS00175 ENOG4107ZHV Transcriptional regulator HH306_RS00185 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HH306_RS00190 ENOG4108MGI Transcriptional regulator HH306_RS00195 ENOG4105WKW Pfam:DUF1458 HH306_RS00205 ENOG4105D5K Hemolysin activator protein HH306_RS00210 ENOG4105CKT filamentous hemagglutinin HH306_RS00250 ENOG4107PU6 Membrane HH306_RS00255 ENOG41072JS exoenzyme T HH306_RS00260 ENOG4106B0W Curli production assembly transport component CsgG HH306_RS00270 ENOG4107Y60 (LipO)protein HH306_RS00280 ENOG4105NGS secreted protein HH306_RS00295 ENOG4105CAQ asparagine synthetase HH306_RS00305 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HH306_RS00315 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS00330 ENOG4108Z9K Osmotically inducible protein HH306_RS00335 ENOG4105KBG Protein of unknown function (DUF1161) HH306_RS00360 ENOG4107XGZ Hydrolase HH306_RS00365 ENOG4108Z0R Transferase HH306_RS00370 ENOG4105DGW oligopeptidase A HH306_RS00375 ENOG4105VKU nucleicacid-binding protein HH306_RS00390 ENOG4105E6M Sulphatase-modifying factor protein HH306_RS00405 ENOG4105D9P serine threonine protein kinase HH306_RS00410 ENOG4108ZF3 Phosphatase HH306_RS00425 ENOG4105ER2 Ompa motb domain protein HH306_RS00460 ENOG4108WC9 type VI secretion system effector, hcp1 family HH306_RS00485 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS00510 ENOG4105CS6 Rhs element vgr protein HH306_RS00545 ENOG4107B2H carbonic anhydrase HH306_RS00550 ENOG4105CHH sulfate transporter HH306_RS00565 ENOG4105BZ9 Cytochrome C oxidase, subunit I HH306_RS00570 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) HH306_RS00575 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HH306_RS00610 ENOG4107YB6 acetyltransferase, (GNAT) family HH306_RS00650 ENOG4105CR8 Transcriptional regulator HH306_RS00675 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HH306_RS00685 ENOG4105C26 Dehydrogenase HH306_RS00690 ENOG4105K8K Cupin 2, conserved barrel HH306_RS00695 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH306_RS00700 ENOG4105EVZ LysR family transcriptional regulator HH306_RS00705 ENOG4107QUY Guanine deaminase HH306_RS00710 ENOG4108JQ9 ABC transporter HH306_RS00715 ENOG4105UIB (ABC) transporter HH306_RS00730 ENOG4108JU3 Alkyl hydroperoxide reductase HH306_RS00735 ENOG4105CSR polyphosphate kinase 2 HH306_RS00740 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HH306_RS00790 ENOG4105DDW LysR family Transcriptional regulator HH306_RS00795 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HH306_RS00800 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HH306_RS00805 ENOG4107HP6 Transcriptional regulator HH306_RS00820 ENOG4105BZS acriflavin resistance protein HH306_RS00825 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS00835 ENOG4105J5J Outer membrane porin HH306_RS00845 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HH306_RS00855 ENOG4105C2W permease HH306_RS00860 ENOG4108R86 Transcriptional regulator HH306_RS00890 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HH306_RS00895 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HH306_RS00900 ENOG4105BZU Histidine kinase HH306_RS00905 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS00910 ENOG4108V3W Chemotaxis protein, CheW HH306_RS00915 ENOG4105CBS Chea signal transduction histidine kinase HH306_RS00920 ENOG4108VYJ response regulator receiver protein HH306_RS00930 ENOG4105EJC lysr family transcriptional regulator HH306_RS00935 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HH306_RS00940 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HH306_RS00945 ENOG4105E2Y ABC, transporter HH306_RS00950 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH306_RS00955 ENOG4107Z6I Thiamine biosynthesis protein HH306_RS00970 ENOG4105J5J Outer membrane porin HH306_RS01000 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HH306_RS01005 ENOG4105W8H transhydrogenase (subunit alpha HH306_RS01010 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HH306_RS01015 ENOG4105WQ5 TonB family HH306_RS01025 ENOG4105SG9 biopolymer transport protein, ExbD HH306_RS01065 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HH306_RS01070 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HH306_RS01085 ENOG4108K70 Transcriptional regulator HH306_RS01095 ENOG4105C26 Dehydrogenase HH306_RS01100 ENOG4105C85 amino acid HH306_RS01105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH306_RS01115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH306_RS01120 ENOG4108S8N class II Aldolase HH306_RS01140 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS01145 ENOG4105CSH Transporter HH306_RS01150 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HH306_RS01155 ENOG4105F2Z 3-oxoadipate enol-lactonase HH306_RS01160 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HH306_RS01175 ENOG4105D2S major facilitator superfamily HH306_RS01185 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HH306_RS01200 ENOG41090KI Outer membrane porin HH306_RS01205 ENOG4108I5G Major Facilitator superfamily HH306_RS01210 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HH306_RS01215 ENOG4108W9H Tetr family transcriptional regulator HH306_RS01220 ENOG4107S9B Shikimate dehydrogenase HH306_RS01225 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HH306_RS01230 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH306_RS01235 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HH306_RS01250 ENOG4105CJW magnesium transporter HH306_RS01265 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HH306_RS01270 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HH306_RS01310 ENOG4105CS6 Rhs element vgr protein HH306_RS01315 ENOG4108WC9 type VI secretion system effector, hcp1 family HH306_RS01345 ENOG4105C26 Dehydrogenase HH306_RS01350 ENOG4108JPW Aminotransferase HH306_RS01355 ENOG4108VYJ response regulator receiver protein HH306_RS01365 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HH306_RS01380 ENOG4105G2Y Transcriptional regulator HH306_RS01385 ENOG4105DJ2 Major Facilitator Superfamily HH306_RS01405 ENOG4108K0D peptidase, M48 HH306_RS01420 ENOG4108IJ6 ABC transporter HH306_RS01425 ENOG4105ECW sulfate abc transporter HH306_RS01430 ENOG4108I5D sulfate abc transporter HH306_RS01435 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HH306_RS01445 ENOG4105BZU Histidine kinase HH306_RS01455 ENOG4105CK7 Sodium proline symporter HH306_RS01460 ENOG4105CYW agmatinase HH306_RS01465 ENOG4105EVZ LysR family transcriptional regulator HH306_RS01470 ENOG4105BZU Histidine kinase HH306_RS01475 ENOG41090KI Outer membrane porin HH306_RS01495 ENOG4107RUE extracellular solute-binding protein family 1 HH306_RS01500 ENOG4105CFQ glutamine synthetase HH306_RS01505 ENOG4108Z86 Glutamine amidotransferase HH306_RS01510 ENOG4105CFQ glutamine synthetase HH306_RS01515 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH306_RS01525 ENOG4108HM4 ABC transporter HH306_RS01530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS01535 ENOG4105F38 ABC transporter, permease HH306_RS01540 ENOG4105D38 putrescine abc transporter HH306_RS01590 ENOG4105E5Q amino acid AbC transporter HH306_RS01605 ENOG4108JQ1 Dehydrogenase HH306_RS01610 ENOG4105CQB FAD linked oxidase domain protein HH306_RS01615 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HH306_RS01625 ENOG4105H4F exported protein HH306_RS01630 ENOG41067B5 Histone deacetylase superfamily protein HH306_RS01635 ENOG4105CUB amino acid HH306_RS01640 ENOG4107FKK extracellular solute-binding protein family 1 HH306_RS01645 ENOG4105D38 putrescine abc transporter HH306_RS01655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS01660 ENOG4108ZK4 sdia-regulated domain-containing protein HH306_RS01665 ENOG4108MXK alkaline phosphatase isozyme conversion HH306_RS01670 ENOG4105KWI UPF0339 protein HH306_RS01680 ENOG4105C7B Threonine dehydratase HH306_RS01690 ENOG4105CGD Nad-dependent epimerase dehydratase HH306_RS01715 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HH306_RS01720 ENOG4105BZU Histidine kinase HH306_RS01730 ENOG4105HF0 Membrane HH306_RS01765 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HH306_RS01785 ENOG4108RE9 Phosphodiesterase HH306_RS01790 ENOG4105C2W permease HH306_RS01800 ENOG4105DR4 Methyltransferase HH306_RS01805 ENOG4107RKG DJ-1/PfpI family HH306_RS01840 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HH306_RS01860 ENOG4107RGH Aldehyde dehydrogenase HH306_RS01875 ENOG4105DNZ Alpha Beta Hydrolase HH306_RS01885 ENOG4106H78 methyltransferase HH306_RS01900 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HH306_RS01905 ENOG4105CAK Cell division ATP-binding protein ftsE HH306_RS01910 ENOG4105CRP Part of the ABC transporter FtsEX involved in HH306_RS01915 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH306_RS01925 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HH306_RS01935 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HH306_RS01945 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HH306_RS01950 ENOG4105D25 secreted protein HH306_RS01965 ENOG4105CSA Coproporphyrinogen iii oxidase HH306_RS01970 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HH306_RS01980 ENOG4105DWV Homoserine O-trans-acetylase HH306_RS01985 ENOG4105DWV Homoserine O-trans-acetylase HH306_RS01990 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HH306_RS01995 ENOG4105VZ9 UPF0235 protein HH306_RS02000 ENOG4108VIA integral membrane protein HH306_RS02005 ENOG4105II7 pyrroline-5-carboxylate reductase HH306_RS02010 ENOG4105DFA alanine racemase domain protein HH306_RS02015 ENOG4105CZX twitching motility protein HH306_RS02020 ENOG4105CZX twitching motility protein HH306_RS02040 ENOG4105C28 cystathionine HH306_RS02045 ENOG4105CD3 dihydroorotase HH306_RS02075 ENOG4105D7Z glutathione synthase HH306_RS02080 ENOG4108UNF response regulator HH306_RS02085 ENOG4105M3Z response regulator HH306_RS02090 ENOG4108ZGA chew protein HH306_RS02095 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS02100 ENOG4105BZU Histidine kinase HH306_RS02135 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HH306_RS02150 ENOG4105DS1 cytochrome b561 HH306_RS02160 ENOG4107MHI Transcriptional regulator, MarR family HH306_RS02165 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH306_RS02170 ENOG4105BZS acriflavin resistance protein HH306_RS02175 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS02180 ENOG4105C1J atp-dependent rna helicase HH306_RS02190 ENOG4105SYT Methylenetetrahydrofolate reductase HH306_RS02195 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH306_RS02210 ENOG4105CNM Receptor HH306_RS02220 ENOG4108R86 Transcriptional regulator HH306_RS02225 ENOG4105DZC cytosine deaminase HH306_RS02230 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HH306_RS02235 ENOG4107SJI Dehydrogenase HH306_RS02240 ENOG4105BZ8 glutamate synthase HH306_RS02245 ENOG4105CD3 dihydroorotase HH306_RS02250 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HH306_RS02255 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HH306_RS02265 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS02270 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS02280 ENOG4105CJ3 phosphate transporter HH306_RS02290 ENOG4107QX8 SPFH domain, Band 7 family protein HH306_RS02300 ENOG4105EM2 membrane HH306_RS02305 ENOG4105C1J atp-dependent rna helicase HH306_RS02310 ENOG4105VEQ Cold shock protein HH306_RS02315 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HH306_RS02325 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH306_RS02330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS02340 ENOG4106HNH Acyl-transferase HH306_RS02350 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH306_RS02355 ENOG4105EB3 Histidine kinase HH306_RS02360 ENOG4105CT7 inner membrane cred family protein HH306_RS02390 ENOG4105E0K tonB-dependent siderophore receptor HH306_RS02395 ENOG4108S3W Anti-feci sigma factor, fecr HH306_RS02400 ENOG4108SF5 RNA Polymerase HH306_RS02405 ENOG4108U78 Glutathione S-transferase HH306_RS02410 ENOG41060I7 thioesterase Superfamily protein HH306_RS02415 ENOG4105J7D transcriptional regulator HH306_RS02420 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HH306_RS02440 ENOG4105F2Z 3-oxoadipate enol-lactonase HH306_RS02465 ENOG4105FR1 rard protein HH306_RS02470 ENOG4105E27 serine threonine protein kinase HH306_RS02475 ENOG4105F4R Transcriptional regulator mode HH306_RS02480 ENOG4105T42 (LipO)protein HH306_RS02485 ENOG4105MJ2 Competence protein HH306_RS02500 ENOG4105E7W lamb ycsf family protein HH306_RS02505 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HH306_RS02510 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HH306_RS02535 ENOG4108FZ9 Chaperone HH306_RS02550 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HH306_RS02560 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HH306_RS02570 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS02575 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS02580 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS02590 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HH306_RS02600 ENOG4108UMR transcriptional regulator AsnC family HH306_RS02605 ENOG4108ZGY Transcriptional regulator (AsnC family) HH306_RS02610 ENOG4108UMR transcriptional regulator AsnC family HH306_RS02615 ENOG4108ZGY Transcriptional regulator (AsnC family) HH306_RS02620 ENOG4106P6N cytochrome d1 heme region HH306_RS02625 ENOG4105Y7H Cytochrome HH306_RS02630 ENOG4105W2Z cytochrome C, class I HH306_RS02635 ENOG4105F64 nitrite reductase HH306_RS02640 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HH306_RS02645 ENOG4105CCU oxidase (Subunit III) HH306_RS02655 ENOG4108VKQ nitriC oxide reductase HH306_RS02660 ENOG4105DSQ Nitric oxide reductase HH306_RS02665 ENOG4105FAE von Willebrand factor, type A HH306_RS02680 ENOG4105DND Transcriptional regulator HH306_RS02685 ENOG4108RPX mosc domain containing protein HH306_RS02695 ENOG4105C8Y Acetylornithine aminotransferase HH306_RS02700 ENOG41089BK Glutamine amido-transferase HH306_RS02710 ENOG4108UDW Transcriptional regulator, luxr family HH306_RS02715 ENOG4105CJP fad dependent oxidoreductase HH306_RS02725 ENOG4105HA9 of methanol dehydrogenase type HH306_RS02735 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HH306_RS02780 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HH306_RS02785 ENOG4105CV1 Transketolase (EC 2.2.1.1) HH306_RS02795 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HH306_RS02800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HH306_RS02820 ENOG4105D2N Aldolase HH306_RS02840 ENOG4105CBX hi0933 family HH306_RS02845 ENOG4108VKG metal-dependent hydrolase HH306_RS02850 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HH306_RS02855 ENOG4105KAF membrAne HH306_RS02860 ENOG4105E7U AraC family transcriptional regulator HH306_RS02895 ENOG4107H8F HH306_RS02900 ENOG4108UNC HH306_RS02930 ENOG4105BZU Histidine kinase HH306_RS02935 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH306_RS02940 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HH306_RS02965 ENOG4107ZVW dihydroneopterin aldolase HH306_RS02985 ENOG4105ED1 spovr family HH306_RS02995 ENOG4105CYN Serine protein kinase HH306_RS03015 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HH306_RS03020 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HH306_RS03025 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HH306_RS03030 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HH306_RS03035 ENOG4105EHM Aminoglycoside phosphotransferase HH306_RS03040 ENOG4108S0S Nucleotidyl transferase HH306_RS03045 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HH306_RS03060 ENOG4105WH1 Two component transcriptional regulator luxr family HH306_RS03070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS03080 ENOG4105F38 ABC transporter, permease HH306_RS03090 ENOG4105DJV ribulose-phosphate 3-epimerase HH306_RS03095 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH306_RS03100 ENOG4105CRQ synthase (Component I) HH306_RS03110 ENOG4108XTP Transcriptional regulator HH306_RS03115 ENOG4105KSC Transcriptional regulator, TraR DksA family HH306_RS03200 ENOG4105NVB glycoside hydrolase, family 19 HH306_RS03295 ENOG4105DDQ anthranilate synthase HH306_RS03310 ENOG4107RYR Transcriptional regulator, Crp Fnr family HH306_RS03315 ENOG4108UKZ OsmC family HH306_RS03330 ENOG4107YU2 histidine triad (hIT) protein HH306_RS03355 ENOG4108YXA Membrane HH306_RS03380 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HH306_RS03385 ENOG4105DR5 peptidase HH306_RS03390 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HH306_RS03420 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HH306_RS03460 ENOG4105PM1 preprotein translocase subunit SecE HH306_RS03465 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HH306_RS03510 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HH306_RS03550 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HH306_RS03625 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HH306_RS03660 ENOG4105CH6 catalase HH306_RS03665 ENOG4108UWD Iron-storage protein HH306_RS03670 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HH306_RS03675 ENOG4107RDB Major Facilitator HH306_RS03680 ENOG4108UUM single-stranded DNA-binding protein HH306_RS03685 ENOG4105E4F Isochorismate synthase HH306_RS03690 ENOG4105VIA Chorismate mutase HH306_RS03700 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HH306_RS03705 ENOG4105WPR Transcriptional regulator, ARAC family HH306_RS03710 ENOG4105C0W non-ribosomal peptide synthetase HH306_RS03715 ENOG4105C0W non-ribosomal peptide synthetase HH306_RS03735 ENOG4105CNM Receptor HH306_RS03745 ENOG4108VN5 Inherit from COG: PepSY-associated TM helix HH306_RS03755 ENOG41061H0 Monooxygenase HH306_RS03765 ENOG4105JAB phenazine biosynthesis protein, phzf family HH306_RS03785 ENOG4106SDP Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control HH306_RS03795 ENOG4107WY9 o-methyltransferase HH306_RS03800 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS03805 ENOG4105BZS acriflavin resistance protein HH306_RS03810 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH306_RS03820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HH306_RS03825 ENOG4105EGI Transcriptional regulator HH306_RS03830 ENOG4107QWG 2-Nitropropane dioxygenase HH306_RS03835 ENOG4105CPF Cell wall formation (By similarity) HH306_RS03840 ENOG4105C8F Beta-lactamase domain protein HH306_RS03845 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS03855 ENOG4105BZU Histidine kinase HH306_RS03860 ENOG4108ZXC Two component transcriptional regulator, luxr family HH306_RS03865 ENOG4107UBR Extracellular solute-binding protein family 3 HH306_RS03870 ENOG4105EAD ABC transporter HH306_RS03875 ENOG4105DRP amino acid AbC transporter HH306_RS03895 ENOG4105C26 Dehydrogenase HH306_RS03900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH306_RS03905 ENOG4105C54 Major Facilitator superfamily HH306_RS03920 ENOG4105ECQ AraC Family Transcriptional Regulator HH306_RS03940 ENOG4105C7K acetolactate synthase HH306_RS03945 ENOG41090KI Outer membrane porin HH306_RS03960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HH306_RS03975 ENOG4108UQ8 endoribonuclease L-psp HH306_RS03985 ENOG4107RKG DJ-1/PfpI family HH306_RS03990 ENOG4105CAY ferredoxin--nadp reductase HH306_RS03995 ENOG41062ES Transcriptional regulator HH306_RS04000 ENOG4105CNM Receptor HH306_RS04005 ENOG4105CV8 reductase HH306_RS04025 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HH306_RS04045 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS04050 ENOG4105F27 Major Facilitator HH306_RS04055 ENOG4105CR8 Transcriptional regulator HH306_RS04060 ENOG4105CHR reductase HH306_RS04065 ENOG4105TVJ transport system, permease HH306_RS04070 ENOG4105DQ5 transport system permease protein HH306_RS04075 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HH306_RS04080 ENOG4105E0A ABC, transporter HH306_RS04090 ENOG4107RBR Receptor HH306_RS04110 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HH306_RS04115 ENOG4105CPP Dehydrogenase, E1 component HH306_RS04120 ENOG4107R0V Pyruvate dehydrogenase HH306_RS04125 ENOG4106Z86 ATP-nad acox kinase HH306_RS04130 ENOG4105CHR reductase HH306_RS04135 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HH306_RS04155 ENOG4108JJA ABC, transporter HH306_RS04160 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HH306_RS04230 ENOG4105X5T HH306_RS04240 ENOG4108XTP Transcriptional regulator HH306_RS04290 ENOG4105CDU Replicative dna helicase HH306_RS04320 ENOG4105EPF Outer membrane porin HH306_RS04325 ENOG4105C2C drug resistance transporter, Bcr CflA HH306_RS04330 ENOG4108V8F Transcriptional regulator, MarR family HH306_RS04340 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HH306_RS04345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH306_RS04355 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HH306_RS04375 ENOG4105CSP Major Facilitator Superfamily HH306_RS04385 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HH306_RS04390 ENOG4105C26 Dehydrogenase HH306_RS04420 ENOG4105BZU Histidine kinase HH306_RS04430 ENOG4105EWT decarboxylase family HH306_RS04440 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) HH306_RS04445 ENOG4105BZU Histidine kinase HH306_RS04455 ENOG41066YJ Beta-lactamase HH306_RS04460 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS04470 ENOG4105CPI Metal Dependent Phosphohydrolase HH306_RS04480 ENOG4105E18 UPF0276 protein HH306_RS04490 ENOG4109045 doxx family HH306_RS04500 ENOG4105E0F Histidine kinase HH306_RS04525 ENOG4105CHR reductase HH306_RS04535 ENOG4108I5G Major Facilitator superfamily HH306_RS04570 ENOG4107UWN reductase HH306_RS04575 ENOG4105EFA 4-hydroxyphenylacetate HH306_RS04585 ENOG4105CHR reductase HH306_RS04590 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HH306_RS04605 ENOG4105GQR Chaperone HH306_RS04610 ENOG4105CW0 outer membrane usher protein HH306_RS04630 ENOG41068CG regulatoR HH306_RS04635 ENOG4108RU0 short-chain dehydrogenase reductase HH306_RS04670 ENOG4105CUB amino acid HH306_RS04680 ENOG4105E7U AraC family transcriptional regulator HH306_RS04690 ENOG4105C1B dTDP-glucose 4-6-dehydratase HH306_RS04695 ENOG4108YY7 Invasion gene expression up-regulator SirB HH306_RS04700 ENOG4105EIF outer membrane protein W HH306_RS04730 ENOG4107QR8 Thioredoxin HH306_RS04735 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HH306_RS04750 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HH306_RS04760 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HH306_RS04770 ENOG4107YIM Involved in the transcription termination process (By similarity) HH306_RS04775 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HH306_RS04780 ENOG4108ZAI phosphatidylglycerophosphatase a HH306_RS04790 ENOG4108WIW Aspartyl protease HH306_RS04805 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HH306_RS04815 ENOG4105CTB Polyprenyl synthetase HH306_RS04825 ENOG4105CMJ mandelate racemase muconate lactonizing HH306_RS04845 ENOG4105CJ1 ABC, transporter HH306_RS04850 ENOG4105BZU Histidine kinase HH306_RS04860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HH306_RS04870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH306_RS04875 ENOG4105F0N pyrophosphate phospho-hydrolase HH306_RS04880 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HH306_RS04885 ENOG4105DQR SNARE associated Golgi HH306_RS04900 ENOG4105KD7 acetyltransferase HH306_RS04910 ENOG4105CPD ethanolamine ammonia-lyase HH306_RS04915 ENOG4105CUB amino acid HH306_RS04920 ENOG4105C26 Dehydrogenase HH306_RS04925 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HH306_RS04930 ENOG4105DFU Cell wall formation (By similarity) HH306_RS04935 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HH306_RS04945 ENOG4105K4T epimerase HH306_RS04965 ENOG41067MG lrgb family HH306_RS04975 ENOG4108KF1 Membrane HH306_RS05015 ENOG4105CJN penicillin-binding protein HH306_RS05020 ENOG4105CNI cell division protein FtsW HH306_RS05025 ENOG4105CVE Lytic murein transglycosylase HH306_RS05030 ENOG4105K6T rare lipoprotein A HH306_RS05035 ENOG4105DZ1 carboxypeptidase HH306_RS05055 ENOG4105EXG Transcriptional regulator HH306_RS05065 ENOG4105CVE Lytic murein transglycosylase HH306_RS05090 ENOG4105C8T Leucyl-tRNA synthetase HH306_RS05100 ENOG41080C8 DUF218 domain HH306_RS05105 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HH306_RS05110 ENOG4108JU5 Magnesium and cobalt efflux protein HH306_RS05120 ENOG4105C9A Phoh family HH306_RS05145 ENOG4107S5G Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HH306_RS05150 ENOG4105DWF phosphomethylpyrimidine kinase HH306_RS05155 ENOG4105BZU Histidine kinase HH306_RS05165 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS05175 ENOG4105FYV Amp nucleosidase HH306_RS05190 ENOG4108R99 pseudouridine synthase HH306_RS05205 ENOG4105EW9 transcriptional regulator AsnC family HH306_RS05215 ENOG41076HS cation diffusion facilitator family transporter HH306_RS05225 ENOG4105CQ7 ATP-dependent helicase HH306_RS05370 ENOG4105FBW Monooxygenase HH306_RS05380 ENOG4105G4C Periplasmic ligand-binding sensor protein HH306_RS05390 ENOG4105C1J atp-dependent rna helicase HH306_RS05395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS05400 ENOG4108WQH regulatoR HH306_RS05405 ENOG4105BZU Histidine kinase HH306_RS05410 ENOG4105BZU Histidine kinase HH306_RS05415 ENOG4108YYQ gCN5-related N-acetyltransferase HH306_RS05420 ENOG4108YYQ gCN5-related N-acetyltransferase HH306_RS05430 ENOG4105C29 acyl-CoA thioesterase HH306_RS05450 ENOG4106FTQ Taurine ABC transporter, periplasmic HH306_RS05455 ENOG4108IY8 ABC, transporter HH306_RS05460 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HH306_RS05470 ENOG4105EPD Oligopeptide transporter, Opt family HH306_RS05475 ENOG4105C94 Transporter HH306_RS05480 ENOG4108JU7 Transcriptional regulator HH306_RS05485 ENOG4105D01 (LipO)protein HH306_RS05490 ENOG4105C4M (Ubiquinol oxidase) subunit I HH306_RS05495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HH306_RS05505 ENOG4105R1U AraC Family Transcriptional Regulator HH306_RS05515 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS05520 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS05530 ENOG4105D25 secreted protein HH306_RS05535 ENOG41061ZR Transcriptional regulator HH306_RS05545 ENOG4108IAB Phoh family HH306_RS05555 ENOG4105M00 molybdopterin converting factor, subunit 1 HH306_RS05560 ENOG4108ZAF Molybdopterin HH306_RS05565 ENOG4108RIR Molybdenum cofactor biosynthesis protein HH306_RS05570 ENOG4105CVM Molybdenum cofactor synthesis domain protein HH306_RS05630 ENOG4108ZGU inhibitor of vertebrate lysozyme HH306_RS05635 ENOG4105GAV receptor HH306_RS05640 ENOG4108S3W Anti-feci sigma factor, fecr HH306_RS05645 ENOG4108SF5 RNA Polymerase HH306_RS05650 ENOG4105ECQ AraC Family Transcriptional Regulator HH306_RS05655 ENOG4108Q5Y Membrane HH306_RS05660 ENOG4105C5I Dehydrogenase HH306_RS05665 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS05685 ENOG4105Y49 secretion protein, HlyD family HH306_RS05690 ENOG4108IJ8 ABC transporter HH306_RS05695 ENOG4105E90 ABC transporter HH306_RS05700 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HH306_RS05705 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HH306_RS05710 ENOG4105EEQ Na H antiporter HH306_RS05735 ENOG4105E1F short-chain dehydrogenase reductase HH306_RS05755 ENOG4105WH1 Two component transcriptional regulator luxr family HH306_RS05760 ENOG4105BZU Histidine kinase HH306_RS05770 ENOG4105DQQ Major facilitator superfamily MFS_1 HH306_RS05800 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH306_RS05805 ENOG4105E89 ABC transporter HH306_RS05810 ENOG4108SGR YheO domain-containing protein HH306_RS05815 ENOG4105FC8 fad dependent oxidoreductase HH306_RS05830 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS05845 ENOG4105VE1 Phosphatidylcholine synthase HH306_RS05905 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS05925 ENOG41072JS exoenzyme T HH306_RS05935 ENOG4107QWE )-transporter HH306_RS05940 ENOG4105D5T phosphonate abc transporter HH306_RS05945 ENOG4105C7J ABC transporter, permease HH306_RS05975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HH306_RS05985 ENOG4105MYG DNA polymerase iii, chi subunit HH306_RS05995 ENOG4108ZX5 transcriptional regulator HH306_RS06005 ENOG4108M8S permease YjgP YjgQ family protein HH306_RS06010 ENOG4108K5H permease YjgP YjgQ family protein HH306_RS06020 ENOG4105BZU Histidine kinase HH306_RS06065 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HH306_RS06170 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HH306_RS06240 ENOG4105NVB glycoside hydrolase, family 19 HH306_RS06290 ENOG4105VIE preprotein translocase, subunit YajC HH306_RS06295 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HH306_RS06300 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HH306_RS06305 ENOG4107MBR 17 kDa surface antigen HH306_RS06310 ENOG4105ECY inositol monophosphatase HH306_RS06320 ENOG4105D7W serine acetyltransferase HH306_RS06325 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HH306_RS06335 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HH306_RS06340 ENOG4108Z4V iron-sulfur cluster assembly HH306_RS06350 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HH306_RS06355 ENOG4108ZIT Ferredoxin, 2FE-2S HH306_RS06360 ENOG4105WVQ Fe-S assembly protein IscX HH306_RS06400 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HH306_RS06410 ENOG4105CHM Aminotransferase HH306_RS06425 ENOG4105CPC Aldo Keto reductase HH306_RS06440 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HH306_RS06450 ENOG4107RNH Outer membrane receptor FepA HH306_RS06465 ENOG4105DR5 peptidase HH306_RS06475 ENOG41080T7 secreted protein HH306_RS06485 ENOG4108RWI nicotinamidase HH306_RS06490 ENOG4105ECQ AraC Family Transcriptional Regulator HH306_RS06500 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HH306_RS06510 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HH306_RS06515 ENOG4108M0I Transcriptional regulator HH306_RS06520 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HH306_RS06535 ENOG4105DGU Histone deacetylase HH306_RS06555 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HH306_RS06565 ENOG4107R16 Multicopper oxidase HH306_RS06570 ENOG4108Z6B deaminase HH306_RS06590 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HH306_RS06595 ENOG4108ETH Formylglycinamide ribotide synthetase HH306_RS06610 ENOG4105CI1 PTS System HH306_RS06615 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HH306_RS06620 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HH306_RS06625 ENOG4105CE4 GlcNAc 6-P deacetylase HH306_RS06630 ENOG4105FDP GntR family transcriptional regulator HH306_RS06640 ENOG4105E09 nadh pyrophosphatase HH306_RS06645 ENOG4105P8F nudix hydrolase HH306_RS06650 ENOG4108Z0R Transferase HH306_RS06670 ENOG4105CSH Transporter HH306_RS06675 ENOG4108JU6 CBS domain protein HH306_RS06685 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HH306_RS06725 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH306_RS06730 ENOG4105T95 Thiol disulfide interChange protein HH306_RS06735 ENOG4105D6E homoserine dehydrogenase HH306_RS06740 ENOG4105D98 threonine synthase HH306_RS06755 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HH306_RS06780 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HH306_RS06790 ENOG4108VWS Yaeq family HH306_RS06795 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HH306_RS06800 ENOG4105D4Y metalloprotease HH306_RS06805 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS06850 ENOG41068CG regulatoR HH306_RS06865 ENOG4108KSA LysR family transcriptional regulator HH306_RS06875 ENOG4105CSH Transporter HH306_RS06890 ENOG4108KTQ Methyltransferase HH306_RS06900 ENOG4105CBS Chea signal transduction histidine kinase HH306_RS06905 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HH306_RS06945 ENOG4105EUK rtx toxin RtxA HH306_RS06955 ENOG4108UVJ appr-1-p processing domain protein HH306_RS06960 ENOG4105KCK Peptidoglycan-associated lipoprotein HH306_RS06980 ENOG4105W1Y Transcriptional regulator HH306_RS06990 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HH306_RS07000 ENOG41072GX Peptidase M22 Glycoprotease HH306_RS07010 ENOG41081XQ Conserved Protein HH306_RS07015 ENOG4105CR4 methylisocitrate lyase HH306_RS07040 ENOG4105DJY efflux transporter, rnd family, mfp subunit HH306_RS07085 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HH306_RS07090 ENOG4105C9B Cysteine desulfurase HH306_RS07095 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HH306_RS07105 ENOG4105KUZ arsenate reductase HH306_RS07125 ENOG4105EEQ Na H antiporter HH306_RS07130 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) HH306_RS07140 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HH306_RS07155 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HH306_RS07165 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HH306_RS07170 ENOG4105KNE Phosphatidate cytidylyltransferase HH306_RS07180 ENOG4105DZP Membrane-associated zinc metalloprotease HH306_RS07185 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HH306_RS07190 ENOG4105X4K outer membrane chaperone skp HH306_RS07220 ENOG4105BZG amino acid carrier protein HH306_RS07225 ENOG4105C0B DNA polymerase III (alpha subunit) HH306_RS07235 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HH306_RS07255 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HH306_RS07260 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HH306_RS07270 ENOG41066VF YeeE YedE family protein HH306_RS07275 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS07285 ENOG4105C4W S-formylglutathione hydrolase HH306_RS07310 ENOG4108K5P (LipO)protein HH306_RS07315 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH306_RS07320 ENOG4108Z4U Ferredoxin HH306_RS07325 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HH306_RS07335 ENOG4107TH8 cina domain protein HH306_RS07345 ENOG4105Y3E Modulates RecA activity (By similarity) HH306_RS07355 ENOG4105CY0 Metallo-Beta-Lactamase HH306_RS07360 ENOG4107QRI Phosphoketolase HH306_RS07365 ENOG4105VRT cytoplasmic protein HH306_RS07380 ENOG4105D38 putrescine abc transporter HH306_RS07385 ENOG4105F38 ABC transporter, permease HH306_RS07390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS07395 ENOG4106IUH DTW domain containing protein HH306_RS07410 ENOG41080IJ Diacylglycerol kinase HH306_RS07415 ENOG4105CBC glutamate synthase HH306_RS07440 ENOG4105CUB amino acid HH306_RS07445 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH306_RS07450 ENOG4105CSH Transporter HH306_RS07455 ENOG4105CN8 Transcriptional regulator HH306_RS07460 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS07465 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HH306_RS07470 ENOG4105E39 Enoyl-CoA hydratase HH306_RS07475 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH306_RS07480 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS07485 ENOG41090KI Outer membrane porin HH306_RS07490 ENOG4105DZ2 Transcriptional regulator HH306_RS07500 ENOG4105RA2 Membrane HH306_RS07505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HH306_RS07510 ENOG4105E98 transcriptional regulator DeoR family HH306_RS07515 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HH306_RS07520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HH306_RS07525 ENOG4108Z66 YbaK ebsC protein HH306_RS07530 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HH306_RS07535 ENOG4105JAB phenazine biosynthesis protein, phzf family HH306_RS07560 ENOG4105C2C drug resistance transporter, Bcr CflA HH306_RS07570 ENOG41063TF transcriptional regulator (AraC HH306_RS07575 ENOG4105C26 Dehydrogenase HH306_RS07580 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH306_RS07585 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH306_RS07600 ENOG4105CBN LysR family transcriptional regulator HH306_RS07610 ENOG4105EYA deoxyribonuclease HH306_RS07615 ENOG4107B7Y DNA-binding transcriptional regulator FruR HH306_RS07620 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HH306_RS07625 ENOG4105DE4 1-phosphofructokinase HH306_RS07630 ENOG4105DM4 PTS System HH306_RS07635 ENOG4105C6Y Udp-glucose 6-dehydrogenase HH306_RS07650 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH306_RS07660 ENOG4105C3I Nad-dependent epimerase dehydratase HH306_RS07675 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HH306_RS07680 ENOG4105ZJ4 Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate is important for the architecture of biofilms and increases HH306_RS07685 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate HH306_RS07690 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HH306_RS07700 ENOG4105JHR Alginate biosynthesis protein AlgX HH306_RS07705 ENOG4108C0K Bifunctional protein that converts poly(beta-D- mannuronate) to alpha-L-guluronate and that is also part of a periplasmic protein complex that serves as a scaffold that leads the newly formed alginate polymer through the periplasmic space to the outer membrane secretin AlgE HH306_RS07710 ENOG4105Y9T outer membrane protein AlgE HH306_RS07715 ENOG4105XJP alginate biosynthesis protein HH306_RS07720 ENOG4108UIA Alginate biosynthesis protein Alg44 HH306_RS07725 ENOG4105KZJ alginate biosynthesis protein Alg8 HH306_RS07730 ENOG4105C6Y Udp-glucose 6-dehydrogenase HH306_RS07740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS07745 ENOG4105DBV ornithine carbamoyltransferase HH306_RS07760 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HH306_RS07765 ENOG4105M2J Glutaredoxin HH306_RS07770 ENOG4106UW1 Major Facilitator superfamily HH306_RS07775 ENOG4108UQY Iron-storage protein HH306_RS07780 ENOG4105W53 bacterioferritin-associated ferredoxin HH306_RS07785 ENOG4105D3R alkyl hydroperoxide reductase HH306_RS07795 ENOG4105EKE dihydroorotase HH306_RS07815 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH306_RS07825 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS07850 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HH306_RS07855 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HH306_RS07860 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HH306_RS07870 ENOG4105CSM endonuclease III HH306_RS07920 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HH306_RS07945 ENOG4105VJY transcriptional regulator HH306_RS07950 ENOG4108MVS synthase HH306_RS07955 ENOG4105F87 Dehydratase HH306_RS07960 ENOG4105EMK carboxylate amino acid amine transporter HH306_RS07970 ENOG4105K4H Nlp p60 protein HH306_RS07975 ENOG4107R1I NAD-dependent malic enzyme HH306_RS07985 ENOG4105NAE bifunctional deaminase-reductase domain protein HH306_RS07990 ENOG4105CUY Mechanosensitive ion channel HH306_RS07995 ENOG41079KZ Major Facilitator Superfamily HH306_RS08000 ENOG4105C1J atp-dependent rna helicase HH306_RS08020 ENOG4105BZU Histidine kinase HH306_RS08025 ENOG4105DER m42 family HH306_RS08035 ENOG4105CAQ asparagine synthetase HH306_RS08050 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HH306_RS08055 ENOG4105CSR polyphosphate kinase 2 HH306_RS08060 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS08070 ENOG4105DWT malate dehydrogenase (quinone) HH306_RS08080 ENOG4105D3R alkyl hydroperoxide reductase HH306_RS08085 ENOG4105GVF (ABC) transporter HH306_RS08090 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH306_RS08105 ENOG4105GVF (ABC) transporter HH306_RS08110 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HH306_RS08115 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH306_RS08120 ENOG4105E2Y ABC, transporter HH306_RS08125 ENOG4105F4R Transcriptional regulator mode HH306_RS08140 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HH306_RS08145 ENOG4105EUJ GTP cyclohydrolase i HH306_RS08150 ENOG410642E Short chain dehydrogenase HH306_RS08160 ENOG4105QDK Flavodoxin HH306_RS08165 ENOG4108KB2 LysR family Transcriptional regulator HH306_RS08170 ENOG4105VAW lrga family HH306_RS08175 ENOG41067MG lrgb family HH306_RS08180 ENOG4105MP9 class II Aldolase HH306_RS08195 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HH306_RS08200 ENOG4105E39 Enoyl-CoA hydratase HH306_RS08210 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) HH306_RS08225 ENOG4105D25 secreted protein HH306_RS08235 ENOG41063JG Transcriptional regulator HH306_RS08245 ENOG4107RUY (E1 component), alpha subunit HH306_RS08250 ENOG4105CPP Dehydrogenase, E1 component HH306_RS08255 ENOG4105C7S Dehydrogenase HH306_RS08295 ENOG4105X58 receptor HH306_RS08305 ENOG4108JJ6 Type I secretion system ATPase HH306_RS08310 ENOG4107QZV Type I secretion membrane fusion protein HH306_RS08315 ENOG4105DFG type I secretion outer membrane protein HH306_RS08350 ENOG4105DUM transcriptional regulator, lysR family HH306_RS08355 ENOG4105DP0 ferredoxin-NADP reductase HH306_RS08365 ENOG4108T0W nitrous oxide maturation protein NosY HH306_RS08370 ENOG4105CIG ABC transporter HH306_RS08375 ENOG4105DH4 Periplasmic copper-binding protein HH306_RS08380 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) HH306_RS08385 ENOG4105HEE Binding Domain protein HH306_RS08400 ENOG4108R96 Methyltransferase, YaeB family HH306_RS08405 ENOG4105CHR reductase HH306_RS08425 ENOG4105EHI Phosphonate ABC transporter, periplasmic HH306_RS08435 ENOG4107RJJ Transcriptional regulator HH306_RS08450 ENOG4105EKV Phosphonate metabolism protein HH306_RS08455 ENOG4105FT8 Phosphonate metabolism HH306_RS08460 ENOG4105ENV phosphonate C-P lyase system protein PhnK HH306_RS08465 ENOG4105HRV phosphonate c-p lyase system protein phnl HH306_RS08470 ENOG4105FD8 phosphonate metabolism protein PhnM HH306_RS08480 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HH306_RS08530 ENOG4105UPP uncharacterized protein ydcA HH306_RS08540 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein HH306_RS08545 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HH306_RS08550 ENOG4108S3N antar domain-containing protein HH306_RS08555 ENOG4105IW1 AmiS UreI transporter HH306_RS08575 ENOG4105FDR Membrane HH306_RS08580 ENOG4105BZC d-serine deaminase HH306_RS08600 ENOG4106825 Type iv pilus assembly HH306_RS08620 ENOG4107R88 Chemotaxis protein (CheV) HH306_RS08625 ENOG4105BZU Histidine kinase HH306_RS08635 ENOG4108KXV response regulator HH306_RS08645 ENOG4105C9U ATP-dependent DNA helicase RecQ HH306_RS08670 ENOG4105D78 K07001 NTE family protein HH306_RS08705 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HH306_RS08710 ENOG4106A3M Cytochrome p-450 HH306_RS08715 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr HH306_RS08735 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HH306_RS08770 ENOG4105HSS phospholipase C HH306_RS08795 ENOG4105D5T phosphonate abc transporter HH306_RS08800 ENOG4107T9Q phosphonate abc transporter HH306_RS08805 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH306_RS08810 ENOG4105BZU Histidine kinase HH306_RS08815 ENOG4105DIJ Phosphoethanolamine transferase HH306_RS08820 ENOG4107YZX Universal stress protein HH306_RS08825 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HH306_RS08860 ENOG4108SUT Major Facilitator Superfamily HH306_RS08865 ENOG4108Z7G MaoC domain protein dehydratase HH306_RS08870 ENOG4105E8V Alpha Beta Hydrolase Fold protein HH306_RS08875 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS08880 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS08890 ENOG4105CQ7 ATP-dependent helicase HH306_RS08900 ENOG4105K59 histidine triad (HIT) protein HH306_RS08945 ENOG4105JXB ankyrin repeat-containing protein HH306_RS08990 ENOG4108SDF phosphate-selective porin O and P HH306_RS09025 ENOG4107QRT dEAD DEAH box helicase HH306_RS09030 ENOG4105BZU Histidine kinase HH306_RS09045 ENOG4105GAV receptor HH306_RS09055 ENOG4105VEQ Cold shock protein HH306_RS09060 ENOG4105KPY Small multidrug resistance protein HH306_RS09065 ENOG4105C09 Bile acid HH306_RS09085 ENOG4108V1T peptidylprolyl cis-trans isomerase HH306_RS09115 ENOG4105BZU Histidine kinase HH306_RS09120 ENOG4105CN1 protease HH306_RS09125 ENOG4108JA1 polyketide synthase HH306_RS09130 ENOG4105EAC phosphoserine phosphatase HH306_RS09145 ENOG4105F38 ABC transporter, permease HH306_RS09165 ENOG4105D9U N-acetyltransferase HH306_RS09175 ENOG4105D3G Pseudouridine synthase HH306_RS09185 ENOG4107QMS site-determining protein HH306_RS09195 ENOG4105D1S lipid A biosynthesis HH306_RS09205 ENOG4105EUB pirin domain protein HH306_RS09210 ENOG410903C (LipO)protein HH306_RS09230 ENOG41062QD Membrane HH306_RS09235 ENOG4107QN1 sodium solute HH306_RS09265 ENOG4105BZ1 (ABC) transporter HH306_RS09270 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HH306_RS09275 ENOG41082A2 Alpha beta hydrolase HH306_RS09290 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HH306_RS09300 ENOG4108Z7R Chaperone CsaA HH306_RS09315 ENOG4105BZF Glycosyl transferase (Group 1 HH306_RS09320 ENOG4105F8J Adenylate Guanylate cyclase HH306_RS09330 ENOG4108ZX5 transcriptional regulator HH306_RS09345 ENOG4105DHJ ABC, transporter HH306_RS09355 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HH306_RS09360 ENOG4105PI0 Ferredoxin HH306_RS09365 ENOG41069NU Nitroreductase HH306_RS09375 ENOG410804D Sensor Signal Transduction Histidine Kinase HH306_RS09385 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH306_RS09395 ENOG4105K9H YciI-like protein HH306_RS09405 ENOG4105DB7 PHP domain protein HH306_RS09410 ENOG4107RTD sua5 ycio yrdc ywlc family protein HH306_RS09415 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HH306_RS09420 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HH306_RS09435 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HH306_RS09440 ENOG4105C01 Dihydroxy-acid dehydratase HH306_RS09455 ENOG4105E0F Histidine kinase HH306_RS09480 ENOG4108IJ9 (ABC) transporter HH306_RS09485 ENOG4105TW1 Carbohydrate-selective porin OprB HH306_RS09490 ENOG4105DSB aldose 1-epimerase HH306_RS09495 ENOG4106KNT transcriptional regulator HH306_RS09500 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HH306_RS09505 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) HH306_RS09510 ENOG4108UHU Aldolase HH306_RS09520 ENOG4105FE9 pseudouridine synthase HH306_RS09530 ENOG4105BZU Histidine kinase HH306_RS09535 ENOG4105D6U Sodium Glutamate Symporter HH306_RS09540 ENOG41088SP formiminoglutamate hydrolase HH306_RS09550 ENOG4105UBK short-chain dehydrogenase reductase HH306_RS09555 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH306_RS09565 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HH306_RS09575 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH306_RS09585 ENOG4105CQC Prephenate dehydratase HH306_RS09590 ENOG4105CIH Imidazole acetol-phosphate transaminase HH306_RS09595 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HH306_RS09605 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HH306_RS09625 ENOG4107QQG Dehydrogenase HH306_RS09630 ENOG4107R5Z Oxidoreductase domain protein HH306_RS09635 ENOG4105EXC Acyl-transferase HH306_RS09640 ENOG4105J5G Transferase hexapeptide repeat containing protein HH306_RS09645 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH306_RS09660 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HH306_RS09665 ENOG4108REZ Imidazole glycerol phosphate synthase HH306_RS09670 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HH306_RS09680 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HH306_RS09695 ENOG4105ESV Glycosyl transferase, family 4 HH306_RS09720 ENOG4105CGF Aromatic amino acid aminotransferase HH306_RS09725 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HH306_RS09740 ENOG4105HEI LysR family (Transcriptional regulator HH306_RS09745 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HH306_RS09775 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HH306_RS09780 ENOG4108UHU Aldolase HH306_RS09790 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HH306_RS09795 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH306_RS09815 ENOG4105HEI LysR family (Transcriptional regulator HH306_RS09820 ENOG4105KME endoribonuclease L-psp HH306_RS09825 ENOG4108MP6 LysR family Transcriptional regulator HH306_RS09840 ENOG4105F2W methyltransferase HH306_RS09845 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HH306_RS09850 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HH306_RS09855 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HH306_RS09865 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HH306_RS09880 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HH306_RS09885 ENOG41063M6 Cell Division Protein HH306_RS09890 ENOG4105E96 Colicin v production protein HH306_RS09895 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HH306_RS09900 ENOG4105C28 cystathionine HH306_RS09905 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HH306_RS09910 ENOG4105GVR general secretion pathway protein D HH306_RS09915 ENOG4106I3Z HH306_RS09920 ENOG4107QHF type ii secretion system protein e HH306_RS09925 ENOG4105D7Q type ii secretion system HH306_RS09930 ENOG4108VAU general secretion pathway protein G HH306_RS09935 ENOG4105VWV general secretion pathway protein h HH306_RS09940 ENOG4105X5Z General secretion pathway protein I HH306_RS09945 ENOG4108WWZ General secretion pathway protein J HH306_RS09950 ENOG4108RTD type II secretion system protein K HH306_RS09955 ENOG4108ADH Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HH306_RS09960 ENOG41064QQ General secretion pathway HH306_RS09980 ENOG4108ZX5 transcriptional regulator HH306_RS09990 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS10015 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HH306_RS10025 ENOG4105VUT cytoplasmic protein HH306_RS10035 ENOG4105CD8 aminopeptidase N HH306_RS10045 ENOG4105D25 secreted protein HH306_RS10065 ENOG4105ETX regulatoR HH306_RS10100 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HH306_RS10110 ENOG4105C7I Dehydrogenase HH306_RS10120 ENOG4105D3W isochorismatase HH306_RS10130 ENOG4105GSQ TM1410 hypothetical-related protein HH306_RS10155 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH306_RS10205 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HH306_RS10210 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HH306_RS10215 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HH306_RS10220 ENOG41090ED Protein with unknown function (DUF469) HH306_RS10225 ENOG4108WQH regulatoR HH306_RS10230 ENOG4105BZU Histidine kinase HH306_RS10260 ENOG4105EPF Outer membrane porin HH306_RS10265 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HH306_RS10280 ENOG4105J7D transcriptional regulator HH306_RS10310 ENOG4108RIR Molybdenum cofactor biosynthesis protein HH306_RS10315 ENOG4105CVM Molybdenum cofactor synthesis domain protein HH306_RS10330 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HH306_RS10335 ENOG4108CWB sugar kinase ygcE HH306_RS10340 ENOG4107TE5 Lipid kinase HH306_RS10355 ENOG4107SC1 transglycosylase HH306_RS10360 ENOG4105C5H ABC transporter HH306_RS10370 ENOG41081QV Universal stress protein HH306_RS10390 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS10400 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HH306_RS10415 ENOG4106AIJ Cell Division HH306_RS10435 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HH306_RS10445 ENOG4108JA2 transcriptioN-repair coupling factor HH306_RS10455 ENOG4105C85 amino acid HH306_RS10460 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH306_RS10470 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH306_RS10485 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HH306_RS10490 ENOG4105CJ2 (LipO)protein HH306_RS10505 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HH306_RS10520 ENOG4105D60 lipoprotein releasing system transmembrane protein HH306_RS10525 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HH306_RS10540 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HH306_RS10550 ENOG4109015 Biopolymer transport protein exbD tolR HH306_RS10565 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HH306_RS10575 ENOG4105D4A Cell wall formation (By similarity) HH306_RS10580 ENOG4105C03 ribonuclease HH306_RS10585 ENOG4105EI2 Pseudouridine synthase HH306_RS10590 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH306_RS10595 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HH306_RS10600 ENOG4108UHJ MAF-like protein HH306_RS10605 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HH306_RS10620 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HH306_RS10625 ENOG4105CHR reductase HH306_RS10630 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HH306_RS10635 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HH306_RS10645 ENOG4105HHA aminodeoxychorismate lyase HH306_RS10655 ENOG4107QRG dna polymerase iii HH306_RS10665 ENOG4105F8V Hydrolase, tatD family HH306_RS10670 ENOG4105C9B Cysteine desulfurase HH306_RS10695 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HH306_RS10700 ENOG4105BZJ Electron transfer flavoprotein HH306_RS10705 ENOG4105C10 Electron transfer flavoprotein HH306_RS10720 ENOG4105CIA precorrin-4 C(11)-methyltransferase HH306_RS10725 ENOG4108P62 biosynthesis protein (CbiG) HH306_RS10740 ENOG4107QRP cobalamin biosynthesis protein CobW HH306_RS10745 ENOG4105CTK cobaltochelatase, cobn subunit HH306_RS10750 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH306_RS10765 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS10775 ENOG4105C2W permease HH306_RS10785 ENOG4105CPW cytochrome b561 HH306_RS10795 ENOG4105F27 Major Facilitator HH306_RS10800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS10805 ENOG4108IND Tetr family transcriptional regulator HH306_RS10810 ENOG4108MGI Transcriptional regulator HH306_RS10835 ENOG4108JEH abc transporter atp-binding protein HH306_RS10840 ENOG4106YG3 ABC transporter HH306_RS10845 ENOG4105DSP amino acid AbC transporter HH306_RS10850 ENOG4105E89 ABC transporter HH306_RS10855 ENOG4105CH2 amidohydrolase HH306_RS10860 ENOG4107F9Y LysR family transcriptional regulator HH306_RS10865 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS10895 ENOG4105DQ5 transport system permease protein HH306_RS10905 ENOG4105E0A ABC, transporter HH306_RS10930 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HH306_RS10935 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HH306_RS10940 ENOG41081F0 Precorrin-8x methylmutase HH306_RS10945 ENOG4105DVK Precorrin-2 c20-methyltransferase HH306_RS10970 ENOG41068CG regulatoR HH306_RS10980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH306_RS10985 ENOG4108WQI RNA Polymerase HH306_RS11005 ENOG4105CHR reductase HH306_RS11015 ENOG4108IPT Naphthoate synthase HH306_RS11020 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS11025 ENOG4107QX3 carboxylase HH306_RS11040 ENOG4108RZE Tetr family transcriptional regulator HH306_RS11060 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS11070 ENOG4105CWB LysR family transcriptional Regulator HH306_RS11080 ENOG4105CBN LysR family transcriptional regulator HH306_RS11090 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HH306_RS11100 ENOG4105F8C transglutaminase domain-containing protein HH306_RS11115 ENOG4105BZU Histidine kinase HH306_RS11135 ENOG4105F8V Hydrolase, tatD family HH306_RS11140 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HH306_RS11145 ENOG4108VGI doxx family HH306_RS11150 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HH306_RS11155 ENOG4107IFA Lipase (EC 3.1.1.3) HH306_RS11160 ENOG4107XID 2'-5' rna ligase HH306_RS11170 ENOG4108RRZ Transcription elongation factor GreB HH306_RS11175 ENOG4105CV6 ABC transporter, permease HH306_RS11180 ENOG4108I0Y (ABC) transporter HH306_RS11185 ENOG4108UJV acyl-CoA thioesterase i HH306_RS11195 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HH306_RS11220 ENOG4108ZHJ Organic hydroperoxide resistance protein HH306_RS11225 ENOG4105K56 Transcriptional regulator HH306_RS11230 ENOG4105EJC lysr family transcriptional regulator HH306_RS11250 ENOG4105T0Z Conserved Protein HH306_RS11255 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HH306_RS11265 ENOG4105E39 Enoyl-CoA hydratase HH306_RS11275 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HH306_RS11285 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS11295 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH306_RS11305 ENOG41068KF Universal stress protein HH306_RS11330 ENOG4105CHM Aminotransferase HH306_RS11345 ENOG4105K56 Transcriptional regulator HH306_RS11350 ENOG4105BZU Histidine kinase HH306_RS11355 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HH306_RS11360 ENOG4108ZGC gaf domain protein HH306_RS11365 ENOG4107MKT Stringent starvation protein a HH306_RS11450 ENOG4107QPN acyl-Coa dehydrogenase HH306_RS11460 ENOG4108TGY Glutathione S-transferase HH306_RS11465 ENOG4105DA5 (ABC) transporter HH306_RS11470 ENOG4105E3A (ABC) transporter HH306_RS11515 ENOG4106S9K Transcriptional regulator HH306_RS11535 ENOG4105I93 response regulator HH306_RS11550 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HH306_RS11600 ENOG4105NI8 Cytosine-specific methyltransferase HH306_RS11615 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HH306_RS11745 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HH306_RS11775 ENOG4108TFU terminase (Small subunit) HH306_RS11860 ENOG4105NVB glycoside hydrolase, family 19 HH306_RS11945 ENOG4105VMP Transcriptional regulator HH306_RS11985 ENOG4105S64 Formate nitrite transporter HH306_RS11990 ENOG4105CJP fad dependent oxidoreductase HH306_RS12025 ENOG4105BZU Histidine kinase HH306_RS12035 ENOG4105JAB phenazine biosynthesis protein, phzf family HH306_RS12050 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH306_RS12060 ENOG4105EZR dyp-type peroxidase family protein HH306_RS12095 ENOG4105J5J Outer membrane porin HH306_RS12145 ENOG4105W39 Membrane HH306_RS12155 ENOG4107U9T Pfam:Ribonuclease_BN HH306_RS12185 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HH306_RS12220 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HH306_RS12240 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HH306_RS12280 ENOG4105JXR Protein of unknown function (DUF3296) HH306_RS12290 ENOG4108YGG dna repair protein HH306_RS12295 ENOG4108YXQ IS66 Orf2 family protein HH306_RS12300 ENOG4105E5H Transposase HH306_RS12350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS12385 ENOG4108Z6Z Transcriptional regulator HH306_RS12395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS12400 ENOG4108Z4U Ferredoxin HH306_RS12420 ENOG4108HM4 ABC transporter HH306_RS12425 ENOG410829K Lysine exporter protein (Lyse ygga) HH306_RS12430 ENOG4105C6T cysteine synthase HH306_RS12440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS12455 ENOG4108ZX5 transcriptional regulator HH306_RS12475 ENOG4105J5J Outer membrane porin HH306_RS12500 ENOG4107QS8 (LipO)protein HH306_RS12510 ENOG4108S4H thioesterase Superfamily protein HH306_RS12515 ENOG4105KPV Transcriptional regulator HH306_RS12525 ENOG4105NIV Esterase HH306_RS12530 ENOG4107RNH Outer membrane receptor FepA HH306_RS12535 ENOG410804D Sensor Signal Transduction Histidine Kinase HH306_RS12545 ENOG4105CS6 Rhs element vgr protein HH306_RS12550 ENOG4105CNA YD repeat protein HH306_RS12570 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS12575 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HH306_RS12580 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HH306_RS12590 ENOG4107QHF type ii secretion system protein e HH306_RS12595 ENOG4105D7Q type ii secretion system HH306_RS12600 ENOG4108VAU general secretion pathway protein G HH306_RS12605 ENOG4108VAU general secretion pathway protein G HH306_RS12645 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HH306_RS12655 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HH306_RS12670 ENOG4105M0Y HH306_RS12695 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH306_RS12710 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS12715 ENOG4105D3Y Na H antiporter HH306_RS12720 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS12730 ENOG4108I0C methyltransferase HH306_RS12735 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH306_RS12740 ENOG4105C8S subunit m HH306_RS12745 ENOG4105D65 subunit l HH306_RS12755 ENOG4107UFS subunit j HH306_RS12770 ENOG4108IEH NADH dehydrogenase subunit g HH306_RS12775 ENOG4107QIZ NADH dehydrogenase HH306_RS12780 ENOG4105GKE subunit e HH306_RS12810 ENOG4107RET Isocitrate lyase HH306_RS12825 ENOG41082BV acetyltransferase HH306_RS12830 ENOG4105EZE Cupin 4 family protein HH306_RS12835 ENOG4107QTF adenylosuccinate lyase HH306_RS12860 ENOG4105E9K Isocitrate dehydrogenase HH306_RS12870 ENOG4105VEQ Cold shock protein HH306_RS12880 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS12885 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HH306_RS12900 ENOG4105C3M thioredoxin reductase HH306_RS12905 ENOG4105CNU cell division protein FtsK HH306_RS12915 ENOG4105D1H recombination factor protein RarA HH306_RS12925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HH306_RS12930 ENOG4105CHF Glutathione S-transferase HH306_RS12935 ENOG4107QYG anthranilate phosphoribosyltransferase HH306_RS12940 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HH306_RS12950 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HH306_RS12955 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HH306_RS12960 ENOG4108MN8 Membrane HH306_RS12975 ENOG4108T2C cysteine dioxygenase type I HH306_RS12980 ENOG4105C5Q Transcriptional regulator HH306_RS12990 ENOG4105GVF (ABC) transporter HH306_RS13000 ENOG4105FDT acyl-CoA dehydrogenase HH306_RS13005 ENOG4105GVF (ABC) transporter HH306_RS13015 ENOG4105GVF (ABC) transporter HH306_RS13020 ENOG41065KQ synthase HH306_RS13030 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS13055 ENOG4107T3I fad-binding protein HH306_RS13060 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS13075 ENOG4107MVR Transcriptional regulator HH306_RS13085 ENOG4105CJ1 ABC, transporter HH306_RS13090 ENOG4107QWP ABC-2 type transporter HH306_RS13095 ENOG4107QWP ABC-2 type transporter HH306_RS13115 ENOG4108HM4 ABC transporter HH306_RS13120 ENOG4105WH1 Two component transcriptional regulator luxr family HH306_RS13125 ENOG4105D05 Receptor HH306_RS13140 ENOG4105CN2 monooxygenase, FAD-binding HH306_RS13145 ENOG4105WH1 Two component transcriptional regulator luxr family HH306_RS13165 ENOG4105BZU Histidine kinase HH306_RS13185 ENOG4105NF4 modulator of drug activity HH306_RS13190 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HH306_RS13195 ENOG4105VDT -acetyltransferase HH306_RS13215 ENOG4105EEF Alkane 1-monooxygenase HH306_RS13225 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HH306_RS13230 ENOG4105BZU Histidine kinase HH306_RS13240 ENOG4106W3I PA-I galactophilic lectin HH306_RS13280 ENOG4105CHH sulfate transporter HH306_RS13290 ENOG4108NVR Methyl-accepting chemotaxis HH306_RS13320 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS13325 ENOG4108ZX5 transcriptional regulator HH306_RS13340 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS13345 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS13365 ENOG4105DU1 integral membrane protein, terc HH306_RS13375 ENOG4105EXG Transcriptional regulator HH306_RS13380 ENOG4108UYE Lactoylglutathione lyase HH306_RS13385 ENOG4105CGK Exodeoxyribonuclease III HH306_RS13395 ENOG4105CFU surface antigen HH306_RS13405 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HH306_RS13410 ENOG4105E8V Alpha Beta Hydrolase Fold protein HH306_RS13415 ENOG41077RS Phosphatase HH306_RS13430 ENOG4108HPI phosphatidate Cytidylyltransferase HH306_RS13435 ENOG4105CPC Aldo Keto reductase HH306_RS13445 ENOG4105BZG amino acid carrier protein HH306_RS13450 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HH306_RS13455 ENOG4105CIH Imidazole acetol-phosphate transaminase HH306_RS13470 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH306_RS13475 ENOG4105BZS acriflavin resistance protein HH306_RS13480 ENOG4105BZS acriflavin resistance protein HH306_RS13485 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS13545 ENOG4105F57 Anthranilate dioxygenase reductase HH306_RS13550 ENOG4108YS2 small subunit HH306_RS13555 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HH306_RS13565 ENOG4108KB2 LysR family Transcriptional regulator HH306_RS13570 ENOG4105DTQ mandelate racemase muconate lactonizing HH306_RS13575 ENOG4105NN7 muconolactone delta-isomerase HH306_RS13580 ENOG410626B catechol 1,2-dioxygenase HH306_RS13590 ENOG4105J5J Outer membrane porin HH306_RS13615 ENOG4105DJ2 Major Facilitator Superfamily HH306_RS13620 ENOG4107Y2X deaminase HH306_RS13630 ENOG4105JQN Transcriptional regulator HH306_RS13695 ENOG4105DEN Luciferase family HH306_RS13700 ENOG41090Y2 cytochrome C HH306_RS13705 ENOG4105NQN cytochrome C HH306_RS13710 ENOG4105DHQ Histidine kinase HH306_RS13715 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH306_RS13720 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HH306_RS13730 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HH306_RS13745 ENOG4108RXX maleylacetoacetate isomerase HH306_RS13750 ENOG4105D2S major facilitator superfamily HH306_RS13765 ENOG4107R11 Transcriptional regulator HH306_RS13770 ENOG4108SF5 RNA Polymerase HH306_RS13775 ENOG4108S3W Anti-feci sigma factor, fecr HH306_RS13795 ENOG4105D5K Hemolysin activator protein HH306_RS13800 ENOG4105CKT filamentous hemagglutinin HH306_RS13845 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HH306_RS13855 ENOG4105E93 esterase HH306_RS13875 ENOG4105EJC lysr family transcriptional regulator HH306_RS13880 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HH306_RS13885 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HH306_RS13890 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HH306_RS13895 ENOG4105EJQ L-serine dehydratase HH306_RS13900 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HH306_RS13950 ENOG4108NUU Transcriptional regulator HH306_RS13955 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HH306_RS13965 ENOG4105Y49 secretion protein, HlyD family HH306_RS13975 ENOG4105CSR polyphosphate kinase 2 HH306_RS14015 ENOG4105J5J Outer membrane porin HH306_RS14020 ENOG4105CHJ isochorismatase hydrolase HH306_RS14025 ENOG4105EUB pirin domain protein HH306_RS14030 ENOG4105HEI LysR family (Transcriptional regulator HH306_RS14035 ENOG4105E53 ec 3.2.1.28 HH306_RS14075 ENOG4105FDK ABC transporter HH306_RS14120 ENOG4105CNM Receptor HH306_RS14125 ENOG4105IBP Cyclic peptide transporter HH306_RS14130 ENOG4108V3E phosphoribosylglycinamide formyltransferase HH306_RS14155 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS14165 ENOG4105DJY efflux transporter, rnd family, mfp subunit HH306_RS14180 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HH306_RS14185 ENOG4107SQI penicillin amidase HH306_RS14195 ENOG4108MGI Transcriptional regulator HH306_RS14200 ENOG4105DMF Dehydrogenase HH306_RS14230 ENOG4108ZXC Two component transcriptional regulator, luxr family HH306_RS14245 ENOG4105CS6 Rhs element vgr protein HH306_RS14260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS14320 ENOG4107SM7 Transcriptional regulator HH306_RS14330 ENOG4108UZX fmn reductase HH306_RS14335 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HH306_RS14340 ENOG4107T8P acyl-Coa dehydrogenase HH306_RS14345 ENOG4107SM7 Transcriptional regulator HH306_RS14350 ENOG4105D6Z AFG1 family ATPase HH306_RS14355 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HH306_RS14360 ENOG4108UMI ABC transporter, permease HH306_RS14365 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS14370 ENOG4105D01 (LipO)protein HH306_RS14380 ENOG4107T8P acyl-Coa dehydrogenase HH306_RS14395 ENOG4107Y7Q pfkb domain protein HH306_RS14400 ENOG4105CMG Carbohydrate kinase HH306_RS14405 ENOG4105DEI Mannitol dehydrogenase HH306_RS14410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH306_RS14420 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HH306_RS14440 ENOG4107ZSV Receptor HH306_RS14455 ENOG4105E7U AraC family transcriptional regulator HH306_RS14470 ENOG4105D7T ABC transporter HH306_RS14475 ENOG4105I5W Transporter HH306_RS14490 ENOG4107T8P acyl-Coa dehydrogenase HH306_RS14500 ENOG4105C26 Dehydrogenase HH306_RS14510 ENOG4105C6Z Gluconate HH306_RS14515 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HH306_RS14520 ENOG4105DIQ Transcriptional regulator HH306_RS14530 ENOG4105CJP fad dependent oxidoreductase HH306_RS14535 ENOG4105HEI LysR family (Transcriptional regulator HH306_RS14540 ENOG4107S1E Beta-lactamase HH306_RS14555 ENOG4108JCI Transcriptional regulator HH306_RS14605 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS14605 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS14615 ENOG4105E03 chitinase HH306_RS14625 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HH306_RS14640 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH306_RS14660 ENOG4105TW1 Carbohydrate-selective porin OprB HH306_RS14665 ENOG4105DZG Dehydrogenase HH306_RS14670 ENOG4105CHB tonB-dependent Receptor HH306_RS14715 ENOG4105CAU Arsenical resistance protein, ArsH HH306_RS14720 ENOG4107WAU Protein tyrosine phosphatase HH306_RS14730 ENOG41082YX Transcriptional regulator, arsr family HH306_RS14735 ENOG4105CF7 AraC family transcriptional regulator HH306_RS14740 ENOG4105DQ4 alcohol dehydrogenase HH306_RS14750 ENOG4108Z4X TRANSCRIPTIONal HH306_RS14755 ENOG4105CJN penicillin-binding protein HH306_RS14760 ENOG4105XYF acetyltransferase HH306_RS14775 ENOG4105KAC Antibiotic biosynthesis monooxygenase HH306_RS14805 ENOG4105C5I Dehydrogenase HH306_RS14815 ENOG4105D7K pfkb domain protein HH306_RS14825 ENOG4108M60 Transcriptional regulator HH306_RS14830 ENOG4105JQN Transcriptional regulator HH306_RS14840 ENOG4105EFA 4-hydroxyphenylacetate HH306_RS14855 ENOG4105HDK L-asparaginase HH306_RS14870 ENOG4107QN2 dihydrolipoyl dehydrogenase HH306_RS14875 ENOG4107QSN dihydrolipoamide acetyltransferase HH306_RS14880 ENOG4105CPP Dehydrogenase, E1 component HH306_RS14885 ENOG4107R0V Pyruvate dehydrogenase HH306_RS14890 ENOG4105J0Q Transcriptional regulator HH306_RS14905 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HH306_RS14915 ENOG4105CJR Integral membrane protein (MviN HH306_RS14950 ENOG4105DAY polysaccharide export protein HH306_RS14955 ENOG4108KBE Glycosyl transferase, family 2 HH306_RS14965 ENOG4105D3Q Sugar transferase HH306_RS14975 ENOG4108RPX mosc domain containing protein HH306_RS15020 ENOG4105EQ2 LysR family Transcriptional regulator HH306_RS15025 ENOG4107RTG Major Facilitator superfamily HH306_RS15030 ENOG4105ENX hydrolase HH306_RS15035 ENOG4105CZJ Aldehyde dehydrogenase HH306_RS15045 ENOG4105CXK mandelate racemase muconate lactonizing HH306_RS15050 ENOG4105CSP Major Facilitator Superfamily HH306_RS15055 ENOG4105EPF Outer membrane porin HH306_RS15060 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HH306_RS15070 ENOG4105DJB Major Facilitator Superfamily HH306_RS15110 ENOG4105DRP amino acid AbC transporter HH306_RS15120 ENOG4105BZU Histidine kinase HH306_RS15125 ENOG4106KE4 Dehydrogenase HH306_RS15135 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HH306_RS15140 ENOG4108WUH Transcriptional regulator, TetR family HH306_RS15145 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH306_RS15150 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HH306_RS15155 ENOG41065RR hydrogen cyanide synthase HcnA HH306_RS15165 ENOG41080XP Cbs domain HH306_RS15185 ENOG4105E2A Dehydrogenase HH306_RS15200 ENOG4105WEF catalase HH306_RS15205 ENOG4108N8X transition metal ion binding HH306_RS15220 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HH306_RS15230 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HH306_RS15245 ENOG4105BZU Histidine kinase HH306_RS15275 ENOG4105CN9 Peptidase m42 family protein HH306_RS15310 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HH306_RS15315 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HH306_RS15355 ENOG4105X23 Endonuclease Exonuclease phosphatase HH306_RS15360 ENOG4105DZQ phospholipase D Transphosphatidylase HH306_RS15365 ENOG4107UXM Membrane HH306_RS15370 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HH306_RS15375 ENOG4105CG3 alpha amylase, catalytic region HH306_RS15380 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HH306_RS15385 ENOG4105FDF Could be involved in DNA repair (By similarity) HH306_RS15395 ENOG4105KT7 mgtC SapB transporter HH306_RS15400 ENOG4105CH6 catalase HH306_RS15420 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HH306_RS15440 ENOG4108WTK competence damage-inducible protein HH306_RS15455 ENOG4105DQE DNA ligase HH306_RS15470 ENOG4107VMU Membrane HH306_RS15490 ENOG4105GQR Chaperone HH306_RS15500 ENOG4105CW0 outer membrane usher protein HH306_RS15505 ENOG4105GQR Chaperone HH306_RS15515 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HH306_RS15525 ENOG4105GTN ParB Domain Protein Nuclease HH306_RS15535 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HH306_RS15540 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS15560 ENOG4105CPQ Dehydrogenase HH306_RS15570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH306_RS15595 ENOG4105EPF Outer membrane porin HH306_RS15610 ENOG4107R7A Allophanate hydrolase subunit 2 HH306_RS15640 ENOG4107RN6 Monooxygenase HH306_RS15660 ENOG4105K6V RNA polymerase HH306_RS15665 ENOG4105F27 Major Facilitator HH306_RS15675 ENOG4105FBW Monooxygenase HH306_RS15680 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH306_RS15695 ENOG4105EBM Alpha Beta Hydrolase Fold protein HH306_RS15700 ENOG4106DX9 Aromatic-ring-hydroxylating dioxygenase beta subunit HH306_RS15705 ENOG4105CAQ asparagine synthetase HH306_RS15710 ENOG4105FUY alpha subunit HH306_RS15715 ENOG4105F7P transcriptional regulator AsnC family HH306_RS15720 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HH306_RS15730 ENOG4105C85 amino acid HH306_RS15770 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HH306_RS15775 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH306_RS15785 ENOG4105D8G Major Facilitator superfamily HH306_RS15815 ENOG4105C3J Cysteine desulfurase HH306_RS15820 ENOG4108JQ5 ABC transporter HH306_RS15825 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HH306_RS15830 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HH306_RS15840 ENOG4105D05 Receptor HH306_RS15845 ENOG4105EQ2 LysR family Transcriptional regulator HH306_RS15855 ENOG4105DND Transcriptional regulator HH306_RS15860 ENOG4107B2H carbonic anhydrase HH306_RS15875 ENOG4108SF5 RNA Polymerase HH306_RS15895 ENOG4105CF7 AraC family transcriptional regulator HH306_RS15915 ENOG4105D3G Pseudouridine synthase HH306_RS15925 ENOG4105CUB amino acid HH306_RS15930 ENOG4105CFQ glutamine synthetase HH306_RS15960 ENOG4105C7K acetolactate synthase HH306_RS15975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH306_RS15995 ENOG4108XM1 transcriptional regulator AsnC family HH306_RS16005 ENOG4105DHU Bile acid HH306_RS16010 ENOG4105DC8 reductase HH306_RS16015 ENOG4105HUJ glyoxalase bleomycin resistance protein dioxygenase HH306_RS16020 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HH306_RS16025 ENOG4105C6Y Udp-glucose 6-dehydrogenase HH306_RS16035 ENOG4108IG5 Transcriptional regulator HH306_RS16040 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH306_RS16045 ENOG4105BZS acriflavin resistance protein HH306_RS16055 ENOG4108ZK4 sdia-regulated domain-containing protein HH306_RS16060 ENOG4108Z6Z Transcriptional regulator HH306_RS16065 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS16070 ENOG4107QX3 carboxylase HH306_RS16085 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HH306_RS16100 ENOG4105ERH Fumarylacetoacetate hydrolase HH306_RS16105 ENOG4108RXX maleylacetoacetate isomerase HH306_RS16110 ENOG4105D2S major facilitator superfamily HH306_RS16115 ENOG4108JUB Transcriptional regulator HH306_RS16120 ENOG4105CY2 Citrate transporter HH306_RS16125 ENOG4105DTD Dehydrogenase HH306_RS16130 ENOG4105CRW Short chain fatty acid transporter HH306_RS16135 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS16145 ENOG4105D6N CoA-transferase, subunit a HH306_RS16150 ENOG4108M0I Transcriptional regulator HH306_RS16155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH306_RS16160 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HH306_RS16180 ENOG4105I8F Histidine kinase HH306_RS16210 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HH306_RS16220 ENOG4105C26 Dehydrogenase HH306_RS16225 ENOG4105DZG Dehydrogenase HH306_RS16230 ENOG4105DZG Dehydrogenase HH306_RS16245 ENOG4105BZU Histidine kinase HH306_RS16255 ENOG4108W5X Transcriptional Regulator, LuxR family HH306_RS16265 ENOG4105BZU Histidine kinase HH306_RS16280 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HH306_RS16285 ENOG4105DIJ Phosphoethanolamine transferase HH306_RS16290 ENOG4105CWM branched-chain amino acid transport system II carrier protein HH306_RS16335 ENOG4105C5H ABC transporter HH306_RS16345 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HH306_RS16350 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS16360 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HH306_RS16405 ENOG4108RVA ribokinase HH306_RS16410 ENOG4105ETE Transcriptional regulator (LacI family HH306_RS16415 ENOG4105CNN ABC, transporter HH306_RS16420 ENOG4105C2J ABC transporter HH306_RS16425 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HH306_RS16495 ENOG4107SDU Methyl-accepting chemotaxis HH306_RS16505 ENOG4105D9U N-acetyltransferase HH306_RS16515 ENOG4105DDY UPF0142 protein ycaO HH306_RS16535 ENOG4105D05 Receptor HH306_RS16540 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HH306_RS16545 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH306_RS16560 ENOG4105D5U fad dependent oxidoreductase HH306_RS16590 ENOG4108SF5 RNA Polymerase HH306_RS16595 ENOG4108S3W Anti-feci sigma factor, fecr HH306_RS16605 ENOG4108VN5 Inherit from COG: PepSY-associated TM helix HH306_RS16615 ENOG4107RDB Major Facilitator HH306_RS16635 ENOG4105JAB phenazine biosynthesis protein, phzf family HH306_RS16665 ENOG4105VJY transcriptional regulator HH306_RS16690 ENOG4105CUJ penicillin amidase HH306_RS16705 ENOG4108TGY Glutathione S-transferase HH306_RS16725 ENOG4105CQ2 DNA polymerase HH306_RS16800 ENOG4108VC8 Peptidase family M23 HH306_RS16815 ENOG4105GVR general secretion pathway protein D HH306_RS16835 ENOG4105F2V VRR-NUC domain-containing protein HH306_RS16840 ENOG4108IG5 Transcriptional regulator HH306_RS16845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HH306_RS16850 ENOG4105E0C molybdate abc transporter HH306_RS16855 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HH306_RS16865 ENOG4105HEI LysR family (Transcriptional regulator HH306_RS16875 ENOG4105CKW Inner membrane protein yedI HH306_RS16880 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HH306_RS16890 ENOG4105CJW magnesium transporter HH306_RS16915 ENOG4105XDF Protein of unknown function (DUF1272) HH306_RS16945 ENOG4105C3R Methionine synthase HH306_RS16965 ENOG4105EVD ribosomal RNA large subunit methyltransferase N HH306_RS16975 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HH306_RS17005 ENOG4105ERU peptidase HH306_RS17025 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HH306_RS17030 ENOG4105CHR reductase HH306_RS17035 ENOG4108KB2 LysR family Transcriptional regulator HH306_RS17050 ENOG4105E09 nadh pyrophosphatase HH306_RS17060 ENOG4105E39 Enoyl-CoA hydratase HH306_RS17070 ENOG4105D5Q Arginine ornithine antiporter HH306_RS17075 ENOG4105CXN decarboxylase HH306_RS17085 ENOG4107RZZ dna polymerase iii epsilon subunit HH306_RS17105 ENOG4105E9H Lytic Murein transglycosylase HH306_RS17110 ENOG4105E43 Extracellular solute-binding protein, family 5 HH306_RS17115 ENOG4105E43 Extracellular solute-binding protein, family 5 HH306_RS17120 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HH306_RS17125 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HH306_RS17130 ENOG4108JQ5 ABC transporter HH306_RS17135 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HH306_RS17140 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HH306_RS17150 ENOG4105K70 DNA-binding protein HH306_RS17155 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HH306_RS17165 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HH306_RS17175 ENOG4107EXC regulatoR HH306_RS17180 ENOG4105JJR Histidine kinase HH306_RS17185 ENOG4108A04 Beta-lactamase HH306_RS17225 ENOG4105CX6 glutaminyL-tRNA synthetase HH306_RS17230 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HH306_RS17245 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HH306_RS17250 ENOG4105Q9Y Universal stress protein HH306_RS17260 ENOG4107QIJ Aconitate hydratase 2 HH306_RS17270 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HH306_RS17290 ENOG4108IFG nitrite reductase, (NAD(P)H) HH306_RS17295 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HH306_RS17305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HH306_RS17310 ENOG4105CDV Ompa motb domain protein HH306_RS17355 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HH306_RS17395 ENOG41061ZR Transcriptional regulator HH306_RS17400 ENOG41061ZR Transcriptional regulator HH306_RS17405 ENOG4105CRQ synthase (Component I) HH306_RS17410 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HH306_RS17425 ENOG4107R11 Transcriptional regulator HH306_RS17435 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HH306_RS17445 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH306_RS17485 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HH306_RS17500 ENOG4105CPC Aldo Keto reductase HH306_RS17505 ENOG4105EQ2 LysR family Transcriptional regulator HH306_RS17510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH306_RS17515 ENOG4105CHU acetyl-coa acetyltransferase HH306_RS17560 ENOG4105BZU Histidine kinase HH306_RS17565 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HH306_RS17595 ENOG41070MY type iii secretion HH306_RS17600 ENOG41066XE Type III export protein HH306_RS17630 ENOG4108KB1 transcriptional regulator, arac family HH306_RS17645 ENOG4106V6P Exoenzyme S synthesis protein C HH306_RS17760 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HH306_RS17785 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HH306_RS17810 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HH306_RS17825 ENOG4108DG9 Smr protein MutS2 HH306_RS17830 ENOG4105EUJ GTP cyclohydrolase i HH306_RS17885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS17890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS17935 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH306_RS17950 ENOG4105DKK Benzoate HH306_RS17965 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HH306_RS17975 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS17985 ENOG4105EW6 flavin reductase domain protein, FMN-binding HH306_RS18000 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HH306_RS18025 ENOG4105EEX Two component transcriptional regulator (Winged helix family HH306_RS18030 ENOG4105C08 Histidine kinase HH306_RS18040 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HH306_RS18045 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HH306_RS18055 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS18065 ENOG4105E39 Enoyl-CoA hydratase HH306_RS18070 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH306_RS18075 ENOG41073TP transcriptional regulator HH306_RS18080 ENOG4105DJ2 Major Facilitator Superfamily HH306_RS18085 ENOG4105IPI Membrane HH306_RS18095 ENOG4105CYM Glutathione S-transferase HH306_RS18115 ENOG41063TF transcriptional regulator (AraC HH306_RS18120 ENOG4105KA0 thioesterase Superfamily protein HH306_RS18125 ENOG4108IQE Amp-dependent synthetase and ligase HH306_RS18145 ENOG4107RNH Outer membrane receptor FepA HH306_RS18155 ENOG4105BZU Histidine kinase HH306_RS18195 ENOG4108VHT MarR family transcriptional regulator HH306_RS18200 ENOG4108XHQ (2Fe-2S)-binding domain protein HH306_RS18205 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HH306_RS18210 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HH306_RS18215 ENOG4105R1U AraC Family Transcriptional Regulator HH306_RS18230 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HH306_RS18260 ENOG4105CWM branched-chain amino acid transport system II carrier protein HH306_RS18265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HH306_RS18275 ENOG4107QN2 dihydrolipoyl dehydrogenase HH306_RS18280 ENOG4105C7S Dehydrogenase HH306_RS18285 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HH306_RS18290 ENOG4105E33 succinate dehydrogenase HH306_RS18295 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HH306_RS18300 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HH306_RS18305 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HH306_RS18310 ENOG4105BZN citrate synthase HH306_RS18315 ENOG4105VV6 START domain-containing protein HH306_RS18335 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH306_RS18350 ENOG4108XC3 NADH ubiquinone oxidoreductase HH306_RS18365 ENOG4105DUM transcriptional regulator, lysR family HH306_RS18375 ENOG4105M4H endoribonuclease L-psp HH306_RS18380 ENOG4105CJP fad dependent oxidoreductase HH306_RS18390 ENOG4105CFQ glutamine synthetase HH306_RS18395 ENOG4105CJP fad dependent oxidoreductase HH306_RS18410 ENOG4107QM5 aconitate hydratase HH306_RS18415 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HH306_RS18430 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HH306_RS18445 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) HH306_RS18450 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HH306_RS18465 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) HH306_RS18470 ENOG4105C58 cytochrome c oxidase accessory protein ccog HH306_RS18480 ENOG4105C59 p-type ATPase HH306_RS18495 ENOG4105D4P Coproporphyrinogen iii oxidase HH306_RS18505 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HH306_RS18520 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HH306_RS18535 ENOG4107RN6 Monooxygenase HH306_RS18545 ENOG4106611 bacteriocin immunity HH306_RS18550 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS18565 ENOG4107QMP dna polymerase iii subunits gamma and tau HH306_RS18595 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HH306_RS18605 ENOG4105EEF Alkane 1-monooxygenase HH306_RS18625 ENOG4107QUY Guanine deaminase HH306_RS18635 ENOG4105C7N Xanthine uracil vitamin C permease HH306_RS18640 ENOG4105VT2 5-hydroxyisourate hydrolase HH306_RS18670 ENOG4108WC9 type VI secretion system effector, hcp1 family HH306_RS18675 ENOG4105CS6 Rhs element vgr protein HH306_RS18695 ENOG4105C2W permease HH306_RS18705 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH306_RS18710 ENOG4108R86 Transcriptional regulator HH306_RS18720 ENOG41060W2 glyoxylate carboligase HH306_RS18725 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HH306_RS18730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH306_RS18740 ENOG4105CA9 Pyruvate kinase HH306_RS18750 ENOG4105EYW Ion transport protein HH306_RS18765 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HH306_RS18775 ENOG4105ENY Ethanolamine utilization protein eutH HH306_RS18780 ENOG4105E98 transcriptional regulator DeoR family HH306_RS18785 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HH306_RS18795 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HH306_RS18820 ENOG4108M1T Cytochrome c-type biogenesis protein HH306_RS18825 ENOG4105KWW Biogenesis protein HH306_RS18830 ENOG4107QX9 Thiol disulfide interChange protein HH306_RS18835 ENOG4105DA4 cytochrome c-type biogenesis protein HH306_RS18845 ENOG41067VX Heme exporter protein HH306_RS18850 ENOG41060IM Heme exporter protein HH306_RS18855 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HH306_RS18860 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HH306_RS18875 ENOG4105KNA -acetyltransferase HH306_RS18885 ENOG4105CHR reductase HH306_RS18890 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HH306_RS18915 ENOG4108V3W Chemotaxis protein, CheW HH306_RS18925 ENOG4107QJE Chromosome Partitioning Protein HH306_RS18930 ENOG4105ER2 Ompa motb domain protein HH306_RS18935 ENOG4105E14 MotA TolQ exbB proton channel HH306_RS18940 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HH306_RS18955 ENOG4108VYJ response regulator receiver protein HH306_RS18960 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH306_RS18970 ENOG4105FZW flagellar biosynthesis regulator FlhF HH306_RS18975 ENOG4105D7B Flagellar biosynthesis protein flha HH306_RS18980 ENOG4105HA9 of methanol dehydrogenase type HH306_RS18990 ENOG4105D00 flagellar biosynthetic protein flhB HH306_RS18995 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HH306_RS19000 ENOG4105VS8 Flagellar biosynthetic protein fliq HH306_RS19005 ENOG4105CN7 Flagellar biosynthetic protein FliP HH306_RS19010 ENOG4105VTB flagellar biosynthesis protein fliO HH306_RS19015 ENOG4105DD5 Flagellar motor switch protein HH306_RS19020 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HH306_RS19040 ENOG4105WD1 Membrane HH306_RS19055 ENOG4105BZS acriflavin resistance protein HH306_RS19070 ENOG4105BZU Histidine kinase HH306_RS19075 ENOG4105NNS Autoinducer synthesis protein HH306_RS19085 ENOG4105VJY transcriptional regulator HH306_RS19095 ENOG4105K5X acetyltransferase HH306_RS19105 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HH306_RS19120 ENOG4105K9H YciI-like protein HH306_RS19135 ENOG4105C26 Dehydrogenase HH306_RS19150 ENOG4105CBN LysR family transcriptional regulator HH306_RS19170 ENOG4107SDU Methyl-accepting chemotaxis HH306_RS19175 ENOG4105EVZ LysR family transcriptional regulator HH306_RS19180 ENOG4105CYW agmatinase HH306_RS19200 ENOG4105C7K acetolactate synthase HH306_RS19215 ENOG4105EGI Transcriptional regulator HH306_RS19225 ENOG4105FR1 rard protein HH306_RS19230 ENOG4107RUE extracellular solute-binding protein family 1 HH306_RS19235 ENOG41067B5 Histone deacetylase superfamily protein HH306_RS19240 ENOG4105EGS Mechanosensitive ion channel HH306_RS19245 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HH306_RS19255 ENOG41088T4 Helicase IV HH306_RS19265 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HH306_RS19280 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HH306_RS19300 ENOG4105BZU Histidine kinase HH306_RS19315 ENOG4105CF7 AraC family transcriptional regulator HH306_RS19320 ENOG4105EMU Dehydrogenase HH306_RS19340 ENOG4105WCN acetyltransferase HH306_RS19395 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HH306_RS19430 ENOG4107QI1 Mate efflux family protein HH306_RS19435 ENOG4107AQZ Membrane HH306_RS19450 ENOG4108UIN ybak prolyl-trna synthetase associated region HH306_RS19465 ENOG4105GRZ Ycii-related protein HH306_RS19480 ENOG4105CHP RNA polymerase HH306_RS19490 ENOG4105GRZ Ycii-related protein HH306_RS19500 ENOG4108Q9V regulatoR HH306_RS19505 ENOG4105CXN decarboxylase HH306_RS19510 ENOG4105D7Z glutathione synthase HH306_RS19515 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HH306_RS19525 ENOG4107RP9 extracellular solute-binding protein, family 3 HH306_RS19530 ENOG4105EAD ABC transporter HH306_RS19535 ENOG4105DRP amino acid AbC transporter HH306_RS19540 ENOG4105CDA abc transporter atp-binding protein HH306_RS19545 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HH306_RS19550 ENOG4105HDK L-asparaginase HH306_RS19555 ENOG4105CQZ Histidine kinase HH306_RS19560 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS19565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS19580 ENOG4105EE5 Membrane protein terC HH306_RS19585 ENOG4105E1F short-chain dehydrogenase reductase HH306_RS19595 ENOG410642W LysR family Transcriptional regulator HH306_RS19605 ENOG4105C7B Threonine dehydratase HH306_RS19610 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HH306_RS19625 ENOG4108ESX Receptor HH306_RS19635 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HH306_RS19640 ENOG4105CCU oxidase (Subunit III) HH306_RS19645 ENOG4105BZ9 Cytochrome C oxidase, subunit I HH306_RS19650 ENOG4105E2S oxidase) subunit II HH306_RS19670 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH306_RS19675 ENOG4105JQN Transcriptional regulator HH306_RS19690 ENOG4105DUM transcriptional regulator, lysR family HH306_RS19700 ENOG4105E7A Glutamine amidotransferase HH306_RS19720 ENOG4105C3F Signal peptidase i HH306_RS19730 ENOG4108S3W Anti-feci sigma factor, fecr HH306_RS19735 ENOG410904A RNA polymerase HH306_RS19750 ENOG4105PGM cation diffusion facilitator family transporter HH306_RS19755 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HH306_RS19775 ENOG4105KHC sulfurtransferase HH306_RS19795 ENOG4105ISI outer membrane protein, OMPP1 FadL TodX family HH306_RS19815 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS19830 ENOG4105GN9 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HH306_RS19835 ENOG4108TGR phosphatase HH306_RS19845 ENOG4108YZT Adenosylcobinamide kinase HH306_RS19855 ENOG4105EFT decarboxylase HH306_RS19860 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HH306_RS19865 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HH306_RS19870 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HH306_RS19875 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HH306_RS19880 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH306_RS19890 ENOG4105G3Z GntR family transcriptional regulator HH306_RS19895 ENOG4105CTU Proline racemase HH306_RS19955 ENOG4105DRP amino acid AbC transporter HH306_RS19965 ENOG4105CDA abc transporter atp-binding protein HH306_RS19970 ENOG4105CTU Proline racemase HH306_RS19975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH306_RS19980 ENOG4105CZJ Aldehyde dehydrogenase HH306_RS19985 ENOG4105DG4 malate L-lactate dehydrogenase HH306_RS19995 ENOG41065N1 inhibitor HH306_RS20000 ENOG4105QNJ serralysin (EC 3.4.24.40) HH306_RS20005 ENOG4105DFG type I secretion outer membrane protein HH306_RS20010 ENOG4107QZV Type I secretion membrane fusion protein HH306_RS20015 ENOG4108JJ6 Type I secretion system ATPase HH306_RS20045 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS20050 ENOG4105CW7 secretion protein, HlyD family HH306_RS20075 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HH306_RS20090 ENOG4105R1U AraC Family Transcriptional Regulator HH306_RS20110 ENOG4105DYS nad(p)h dehydrogenase (quinone) HH306_RS20115 ENOG4105DWY Agmatine deiminase HH306_RS20130 ENOG4105DWY Agmatine deiminase HH306_RS20135 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS20150 ENOG4105CA3 membrane-bound lytic murein transglycosylase HH306_RS20175 ENOG4107SDT Homocitrate synthase HH306_RS20185 ENOG4105CEY Amp-dependent synthetase and ligase HH306_RS20190 ENOG4105CAQ asparagine synthetase HH306_RS20200 ENOG4105E5W Transporter HH306_RS20210 ENOG4105C2I pirin domain protein HH306_RS20225 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH306_RS20235 ENOG4105EUB pirin domain protein HH306_RS20240 ENOG4108YYH Nadph-dependent fmn reductase HH306_RS20250 ENOG4105CHJ isochorismatase hydrolase HH306_RS20255 ENOG4105CC0 LysR family Transcriptional regulator HH306_RS20265 ENOG4105K4H Nlp p60 protein HH306_RS20270 ENOG4108QBX (LipO)protein HH306_RS20275 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HH306_RS20280 ENOG4108JUB Transcriptional regulator HH306_RS20285 ENOG4106V2I dimethylaminohydrolase HH306_RS20290 ENOG4105D5Q Arginine ornithine antiporter HH306_RS20295 ENOG4108R3E Dna-3-methyladenine glycosylase i HH306_RS20310 ENOG41069YE inner membrane protein yohC HH306_RS20320 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HH306_RS20325 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS20335 ENOG4105CYM Glutathione S-transferase HH306_RS20340 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS20355 ENOG4105BZU Histidine kinase HH306_RS20365 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH306_RS20380 ENOG4108ZNS ferredoxin-type protein NapF HH306_RS20385 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HH306_RS20405 ENOG4105CVE Lytic murein transglycosylase HH306_RS20410 ENOG4108ZCF integral membrane protein HH306_RS20415 ENOG4107EFQ arachidonate 15-lipoxygenase HH306_RS20435 ENOG4108TSE Transferase HH306_RS20440 ENOG4105CUZ uba thif-type nad fad binding protein HH306_RS20455 ENOG4105DHI Methyltransferase HH306_RS20465 ENOG4105VEQ Cold shock protein HH306_RS20470 ENOG4105JJR Histidine kinase HH306_RS20475 ENOG4107EXC regulatoR HH306_RS20480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH306_RS20485 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH306_RS20505 ENOG4108MA7 Inherit from COG: YD repeat protein HH306_RS20525 ENOG4105CUB amino acid HH306_RS20530 ENOG4105C0A alcohol dehydrogenase HH306_RS20535 ENOG4105EVZ LysR family transcriptional regulator HH306_RS20555 ENOG4105EGI Transcriptional regulator HH306_RS20560 ENOG4105S0E allantoin catabolism protein HH306_RS20580 ENOG4107WYG Transcriptional regulator, luxr family HH306_RS20615 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HH306_RS20620 ENOG410642W LysR family Transcriptional regulator HH306_RS20625 ENOG4108FN7 Aldo keto reductase HH306_RS20635 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HH306_RS20640 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HH306_RS20650 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HH306_RS20655 ENOG4108WS1 HH306_RS20660 ENOG4108KHX Diguanylate cyclase HH306_RS20665 ENOG41090EK ompa motb domain protein HH306_RS20695 ENOG4105BZ1 (ABC) transporter HH306_RS20705 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HH306_RS20710 ENOG4105D8V Glucose sorbosone dehydrogenase HH306_RS20725 ENOG4105R1U AraC Family Transcriptional Regulator HH306_RS20730 ENOG41079KZ Major Facilitator Superfamily HH306_RS20745 ENOG4105GSA Flagellar export protein flij HH306_RS20750 ENOG4108JIR Flagellum-specific ATP synthase HH306_RS20760 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HH306_RS20765 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HH306_RS20780 ENOG4105BZU Histidine kinase HH306_RS20795 ENOG4105MQ3 flagellar protein FliS HH306_RS20800 ENOG4105DTS flagellar hook-associated HH306_RS20805 ENOG41063QE flagellar protein FlaG HH306_RS20810 ENOG4105I03 Flagellin HH306_RS20815 ENOG4107RGC Glycosyl transferase, family 2 HH306_RS20820 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HH306_RS20835 ENOG4105DTJ flagellar hook-associated protein HH306_RS20840 ENOG4105E1Q flagellar hook-associated protein HH306_RS20845 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HH306_RS20860 ENOG4105CGA flagellar basal-body rod protein FlgG HH306_RS20865 ENOG4108KPB Flagellar basal-body rod protein FlgF HH306_RS20870 ENOG4105BZE flagellar hook protein, FlgE HH306_RS20875 ENOG4105W00 Flagellar hook capping protein HH306_RS20880 ENOG4108ZC9 flagellar basal-body rod protein flgc HH306_RS20885 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HH306_RS20900 ENOG4105CP9 extracellular ligand-binding receptor HH306_RS20905 ENOG4105C32 Amino acid ABC transporter (Permease) HH306_RS20910 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HH306_RS20915 ENOG4105C0Z ABC transporter HH306_RS20920 ENOG4108IV0 ABC, transporter HH306_RS20930 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HH306_RS20935 ENOG4105JQN Transcriptional regulator HH306_RS20945 ENOG4105K78 MarR family Transcriptional regulator HH306_RS20965 ENOG4105C6T cysteine synthase HH306_RS20980 ENOG4105W4C monovalent cation H antiporter subunit F HH306_RS20985 ENOG4105SC1 monovalent cation H antiporter subunit E HH306_RS20990 ENOG4107R4Z monovalent cation h antiporter subunit d HH306_RS20995 ENOG4108ZE9 Monovalent cation H antiporter subunit C HH306_RS21000 ENOG4105D65 subunit l HH306_RS21005 ENOG4108XTF Outer Membrane Lipoprotein HH306_RS21015 ENOG4105BZW Glycerate kinase HH306_RS21020 ENOG4105C6Z Gluconate HH306_RS21025 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HH306_RS21035 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 HH306_RS21050 ENOG4105DVT helicase HH306_RS21070 ENOG4105CDV Ompa motb domain protein HH306_RS21090 ENOG4105EN6 Membrane HH306_RS21105 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HH306_RS21110 ENOG4105CYM Glutathione S-transferase HH306_RS21115 ENOG4105CUJ penicillin amidase HH306_RS21120 ENOG4105CGY Dna recombination protein HH306_RS21135 ENOG4105CJP fad dependent oxidoreductase HH306_RS21140 ENOG4105C26 Dehydrogenase HH306_RS21155 ENOG4105EPF Outer membrane porin HH306_RS21160 ENOG4105EA8 2-Nitropropane dioxygenase HH306_RS21165 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HH306_RS21170 ENOG4105CC9 acyl-Coa dehydrogenase HH306_RS21175 ENOG4105E39 Enoyl-CoA hydratase HH306_RS21180 ENOG4105D2B acyl-CoA dehydrogenase HH306_RS21190 ENOG4107RGD Major Facilitator superfamily HH306_RS21220 ENOG4107QJZ Glycosyl transferase, family 2 HH306_RS21260 ENOG4105CY0 Metallo-Beta-Lactamase HH306_RS21265 ENOG4105GJM (LipO)protein HH306_RS21270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH306_RS21280 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HH306_RS21290 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HH306_RS21295 ENOG4105ERG peptidase m48, ste24p HH306_RS21310 ENOG4105DDQ anthranilate synthase HH306_RS21315 ENOG4105CRQ synthase (Component I) HH306_RS21320 ENOG4105R2E Metallo-beta-lactamase superfamily HH306_RS21325 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HH306_RS21330 ENOG4108MJ1 3-oxoacyl-(ACP) synthase HH306_RS21340 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH306_RS21345 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH306_RS21350 ENOG4105CW0 outer membrane usher protein HH306_RS21355 ENOG4108AF8 Chaperone HH306_RS21390 ENOG4108MA7 Inherit from COG: YD repeat protein HH306_RS21430 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HH306_RS21435 ENOG4105UFD tol-pal system protein YbgF HH306_RS21440 ENOG4105KCK Peptidoglycan-associated lipoprotein HH306_RS21445 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HH306_RS21455 ENOG4105M8F Biopolymer transport protein exbD tolR HH306_RS21460 ENOG4105E02 MotA TolQ exbB proton channel HH306_RS21465 ENOG4107YD3 Thioesterase HH306_RS21500 ENOG4105VEQ Cold shock protein HH306_RS21515 ENOG4105J5J Outer membrane porin HH306_RS21535 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HH306_RS21540 ENOG4105R2R Thioredoxin HH306_RS21565 ENOG4105CS1 NAD(P)H quinone oxidoreductase HH306_RS21575 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HH306_RS21585 ENOG4105CXB phosphoribosylaminoimidazole synthetase HH306_RS21590 ENOG4108V3E phosphoribosylglycinamide formyltransferase HH306_RS21630 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HH306_RS21640 ENOG4105DXN mazG family HH306_RS21645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH306_RS21655 ENOG4105C6T cysteine synthase HH306_RS21660 ENOG4107RNH Outer membrane receptor FepA HH306_RS21665 ENOG410804D Sensor Signal Transduction Histidine Kinase HH306_RS21675 ENOG4105BZU Histidine kinase HH306_RS21680 ENOG4105C5I Dehydrogenase HH306_RS21695 ENOG4105E68 Sulfatase HH306_RS21730 ENOG4108VKM cytochrome b561 HH306_RS21740 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HH306_RS21745 ENOG4108W15 Protein of unknown function (DUF1456) HH306_RS21755 ENOG4105CJW magnesium transporter HH306_RS21790 ENOG4108XTP Transcriptional regulator HH306_RS21815 ENOG4105CFH Aspartokinase HH306_RS21820 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HH306_RS21825 ENOG4105C5W Aldolase HH306_RS21845 ENOG4105C26 Dehydrogenase HH306_RS21850 ENOG4105F4X arginine HH306_RS21855 ENOG4108T2Z Arginine HH306_RS21860 ENOG4105C8Y Acetylornithine aminotransferase HH306_RS21870 ENOG4105ECQ AraC Family Transcriptional Regulator HH306_RS21875 ENOG4108JEH abc transporter atp-binding protein HH306_RS21890 ENOG4105DSP amino acid AbC transporter HH306_RS21895 ENOG4105E89 ABC transporter HH306_RS21900 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH306_RS21905 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HH306_RS21910 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ HH306_RS21915 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HH306_RS21920 ENOG4105CI0 Citrate lyase HH306_RS21935 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HH306_RS21940 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS21945 ENOG4108M9J MaoC like domain protein HH306_RS21955 ENOG4105EJC lysr family transcriptional regulator HH306_RS21970 ENOG4108JU8 Transcriptional regulator HH306_RS21975 ENOG4105MIR Phenylalanine 4-monooxygenase HH306_RS21985 ENOG4105CGF Aromatic amino acid aminotransferase HH306_RS21990 ENOG41061WM D-Alanyl-D-Alanine HH306_RS21995 ENOG4108YZN class I peptide chain release factor HH306_RS22000 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme HH306_RS22005 ENOG4105C85 amino acid HH306_RS22010 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HH306_RS22035 ENOG4105BZU Histidine kinase HH306_RS22055 ENOG4105M85 Bola protein HH306_RS22070 ENOG4105C9Q fumarate hydratase class II HH306_RS22080 ENOG4108M1A Chitin-binding protein HH306_RS22095 ENOG4105C3M thioredoxin reductase HH306_RS22100 ENOG4105D3R alkyl hydroperoxide reductase HH306_RS22105 ENOG4105BZU Histidine kinase HH306_RS22115 ENOG4107R72 Ceramidase HH306_RS22120 ENOG4105HSS phospholipase C HH306_RS22135 ENOG4108RMV DegV Family HH306_RS22145 ENOG4108WUH Transcriptional regulator, TetR family HH306_RS22150 ENOG4108V06 Glutathione peroxidase HH306_RS22155 ENOG4108YZY peptidylprolyl cis-trans isomerase HH306_RS22170 ENOG4105C6K Malic enzyme HH306_RS22175 ENOG4106HNH Acyl-transferase HH306_RS22180 ENOG4108ZG0 Ompa motb domain protein HH306_RS22185 ENOG4105C5X domain protein HH306_RS22210 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HH306_RS22310 ENOG4108ZG0 Ompa motb domain protein HH306_RS22325 ENOG4108ZX5 transcriptional regulator HH306_RS22335 ENOG4106HB6 Alpha beta hydrolase HH306_RS22340 ENOG4108IG5 Transcriptional regulator HH306_RS22360 ENOG4108VSE mercuric transport protein HH306_RS22365 ENOG4105XIV Mercuric transport protein, periplasmic component HH306_RS22445 ENOG4108ES9 ParB domain protein nuclease HH306_RS22555 ENOG4105CEC DNA methylase N-4 N-6 HH306_RS22570 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HH306_RS22695 ENOG4108ES9 ParB domain protein nuclease HH306_RS22755 ENOG4105D07 Signal peptide peptidase, SppA HH306_RS22890 ENOG41076CZ activating enzyme HH306_RS22895 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS22925 ENOG4105C4R Atp-dependent dna helicase HH306_RS23010 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HH306_RS23030 ENOG4105DUM transcriptional regulator, lysR family HH306_RS23035 ENOG4105DUM transcriptional regulator, lysR family HH306_RS23045 ENOG4105C92 Aminotransferase class V HH306_RS23060 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH306_RS23065 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HH306_RS23075 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HH306_RS23090 ENOG4105CV8 reductase HH306_RS23115 ENOG4105C0D helicase HH306_RS23120 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase HH306_RS23125 ENOG4105DRR Transcriptional regulator, GntR family HH306_RS23130 ENOG4105CR4 methylisocitrate lyase HH306_RS23135 ENOG4105BZN citrate synthase HH306_RS23140 ENOG4108I0Z Aconitate hydratase HH306_RS23145 ENOG4105C7F AcnD-accessory protein PrpF HH306_RS23150 ENOG4105DXD 2-methylcitrate dehydratase HH306_RS23165 ENOG4105C85 amino acid HH306_RS23195 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS23200 ENOG4105CK7 Sodium proline symporter HH306_RS23205 ENOG4105C26 Dehydrogenase HH306_RS23210 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH306_RS23220 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HH306_RS23275 ENOG4105C3F Signal peptidase i HH306_RS23285 ENOG4105C0H protease HH306_RS23295 ENOG4105VQK sigma E regulatory protein, MucB RseB HH306_RS23300 ENOG41069E1 anti sigma-E protein RseA HH306_RS23305 ENOG4105EMN RNA polymerase sigma factor HH306_RS23310 ENOG4108IYU L-aspartate oxidase HH306_RS23320 ENOG4105Y75 tpr repeat protein HH306_RS23325 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HH306_RS23345 ENOG4105EPF Outer membrane porin HH306_RS23365 ENOG4108KK1 membrane protein AbrB duplication HH306_RS23375 ENOG4107RBI VanW family HH306_RS23385 ENOG4105C26 Dehydrogenase HH306_RS23390 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS23395 ENOG4105E39 Enoyl-CoA hydratase HH306_RS23565 ENOG4107SC1 transglycosylase HH306_RS23680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH306_RS23690 ENOG4108RYK Nad-dependent epimerase dehydratase HH306_RS23695 ENOG4105EUZ Beta-lactamase domain protein HH306_RS23740 ENOG4105I08 Pseudouridine synthase HH306_RS23755 ENOG4108YI3 3-hydroxyacyl-CoA-acyl carrier protein transferase HH306_RS23795 ENOG4105EGI Transcriptional regulator HH306_RS23805 ENOG4105EQK -acetyltransferase HH306_RS23810 ENOG4105K64 Glycosyl transferase, family 2 HH306_RS23815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HH306_RS23820 ENOG4105CSH Transporter HH306_RS23835 ENOG4107RSM transcriptional regulator HH306_RS23845 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HH306_RS23870 ENOG4105SG9 biopolymer transport protein, ExbD HH306_RS23875 ENOG4105E02 MotA TolQ exbB proton channel HH306_RS23880 ENOG4105D5K Hemolysin activator protein HH306_RS23895 ENOG4108UPW ABC transporter HH306_RS23900 ENOG4108UPW ABC transporter HH306_RS23905 ENOG4105D7Q type ii secretion system HH306_RS23910 ENOG4107QHF type ii secretion system protein e HH306_RS23915 ENOG4105GVR general secretion pathway protein D HH306_RS23935 ENOG4108VAU general secretion pathway protein G HH306_RS23940 ENOG4105X5Z General secretion pathway protein I HH306_RS23955 ENOG4108WWZ General secretion pathway protein J HH306_RS23980 ENOG4108YNN Heme oxygenase HH306_RS23995 ENOG4105C0B DNA polymerase III (alpha subunit) HH306_RS24025 ENOG4107RH8 nuclease SbcCD subunit D HH306_RS24030 ENOG4105EYH Exonuclease HH306_RS24035 ENOG4107QYX exodeoxyribonuclease v alpha HH306_RS24040 ENOG4107QKA exodeoxyribonuclease V beta HH306_RS24045 ENOG4105DSY exodeoxyribonuclease V, gamma HH306_RS24050 ENOG4108KMH lipoate-protein ligase a HH306_RS24055 ENOG410631K Membrane HH306_RS24070 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS24080 ENOG4105CJ3 phosphate transporter HH306_RS24115 ENOG4105VK0 repeat-containing protein HH306_RS24155 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS24160 ENOG4105D7A ATP-binding protein HH306_RS24165 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS24170 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS24205 ENOG4105CJB Exodeoxyribonuclease I HH306_RS24235 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HH306_RS24265 ENOG4105Q9Y Universal stress protein HH306_RS24270 ENOG4105CA9 Pyruvate kinase HH306_RS24275 ENOG4105E39 Enoyl-CoA hydratase HH306_RS24285 ENOG4105BZU Histidine kinase HH306_RS24290 ENOG4107GFK fumarate HH306_RS24295 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HH306_RS24305 ENOG4107R7Y intracellular protease Pfpi family HH306_RS24320 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HH306_RS24335 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HH306_RS24340 ENOG4105CSH Transporter HH306_RS24345 ENOG4105CH2 amidohydrolase HH306_RS24360 ENOG4105FQP Beta-lactamase HH306_RS24400 ENOG4105F27 Major Facilitator HH306_RS24405 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS24410 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HH306_RS24420 ENOG4105XFK Ferrous iron transport protein A HH306_RS24435 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HH306_RS24460 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH306_RS24465 ENOG4105BZU Histidine kinase HH306_RS24475 ENOG4108V0P LemA family HH306_RS24500 ENOG410624X efflux transporter, rnd family, mfp subunit HH306_RS24505 ENOG4105BZS acriflavin resistance protein HH306_RS24510 ENOG4107RH7 Nicotinate phosphoribosyltransferase HH306_RS24520 ENOG4105FQR PH-inducible protein involved in stress response HH306_RS24530 ENOG4106F60 Histidine kinase HH306_RS24535 ENOG4105ETX regulatoR HH306_RS24570 ENOG4105FS0 cytoplasmic membrane protein HH306_RS24605 ENOG4105D64 Mechanosensitive ion channel HH306_RS24620 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HH306_RS24630 ENOG4108WBT adenosyltransferase HH306_RS24635 ENOG4105M6F mutator MutT protein HH306_RS24645 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HH306_RS24655 ENOG4105E4C Lytic transglycosylase catalytic HH306_RS24670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HH306_RS24675 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HH306_RS24680 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HH306_RS24685 ENOG4105CPF Cell wall formation (By similarity) HH306_RS24700 ENOG4105CNI cell division protein FtsW HH306_RS24705 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HH306_RS24715 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HH306_RS24720 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HH306_RS24725 ENOG4105CJN penicillin-binding protein HH306_RS24735 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HH306_RS24750 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HH306_RS24755 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HH306_RS24770 ENOG4105W4M Transport-associated protein HH306_RS24775 ENOG4105KB2 stringent starvation protein b HH306_RS24780 ENOG4107MKT Stringent starvation protein a HH306_RS24785 ENOG4105EIX cytochrome c1 HH306_RS24790 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HH306_RS24795 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HH306_RS24810 ENOG4105CPC Aldo Keto reductase HH306_RS24815 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS24830 ENOG4105D6Z AFG1 family ATPase HH306_RS24835 ENOG4105C31 Tryptophanyl-tRNA synthetase HH306_RS24840 ENOG4105DHZ alpha beta HH306_RS24850 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HH306_RS24860 ENOG4105CVE Lytic murein transglycosylase HH306_RS24865 ENOG4107QNR UPF0135 protein HH306_RS24870 ENOG4105C0H protease HH306_RS24875 ENOG4105CIH Imidazole acetol-phosphate transaminase HH306_RS24880 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HH306_RS24910 ENOG4107PE3 Mammalian cell entry related domain protein HH306_RS24915 ENOG4105CY3 ABC transporter, permease HH306_RS24920 ENOG4105DHJ ABC, transporter HH306_RS24925 ENOG4105C2X Arabinose 5-phosphate isomerase HH306_RS24930 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HH306_RS24945 ENOG4108IUZ ABC transporter HH306_RS24950 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH306_RS24955 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HH306_RS24960 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HH306_RS24970 ENOG41080Z8 PHOSPHOCARRIER protein HH306_RS24980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH306_RS24990 ENOG4105C9Q fumarate hydratase class II HH306_RS25000 ENOG4105CMS peptidase U62, modulator of DNA gyrase HH306_RS25010 ENOG4105D1U peptidase U62 modulator of DNA gyrase HH306_RS25025 ENOG4105C03 ribonuclease HH306_RS25030 ENOG4108Z03 MAF-like protein HH306_RS25040 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HH306_RS25050 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HH306_RS25055 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HH306_RS25065 ENOG4105K6T rare lipoprotein A HH306_RS25070 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HH306_RS25075 ENOG4105EDV vault protein HH306_RS25080 ENOG41081SK signal peptide protein HH306_RS25085 ENOG4107S52 alpha-2-macroglobulin domain protein HH306_RS25090 ENOG4108QJJ Protein of unknown function (DUF1175) HH306_RS25095 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HH306_RS25100 ENOG4105EDV vault protein HH306_RS25105 ENOG4108UYB regulatoR HH306_RS25110 ENOG4105TX3 Histidine kinase HH306_RS25120 ENOG4105DEF Extracellular solute-binding protein, family 5 HH306_RS25125 ENOG4105DEF Extracellular solute-binding protein, family 5 HH306_RS25140 ENOG4105DEF Extracellular solute-binding protein, family 5 HH306_RS25150 ENOG4105DEF Extracellular solute-binding protein, family 5 HH306_RS25155 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH306_RS25160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH306_RS25165 ENOG4105C3U ABC transporter HH306_RS25170 ENOG4108JQ7 (ABC) transporter HH306_RS25175 ENOG4108NIW Leucine export protein LeuE HH306_RS25180 ENOG4105EW9 transcriptional regulator AsnC family HH306_RS25185 ENOG4107R7A Allophanate hydrolase subunit 2 HH306_RS25195 ENOG4105E7W lamb ycsf family protein HH306_RS25205 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HH306_RS25210 ENOG4108ESX Receptor HH306_RS25225 ENOG4105DIJ Phosphoethanolamine transferase HH306_RS25235 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HH306_RS25240 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS25260 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HH306_RS25275 ENOG4105KHS type IV fimbrial pilin protein HH306_RS25280 ENOG4107QHF type ii secretion system protein e HH306_RS25290 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HH306_RS25295 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HH306_RS25340 ENOG4105CEP NADH dehydrogenase HH306_RS25345 ENOG4105D6Z AFG1 family ATPase HH306_RS25350 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type HH306_RS25360 ENOG4107QJE Chromosome Partitioning Protein HH306_RS25400 ENOG4105CDU Replicative dna helicase HH306_RS25460 ENOG4105C0D helicase HH306_RS25470 ENOG4105YES addiction module antidote protein HH306_RS25475 ENOG4105VUH addiction module killer protein HH306_RS25500 ENOG4107QHF type ii secretion system protein e HH306_RS25515 ENOG4107QHF type ii secretion system protein e HH306_RS25685 ENOG4105CHH sulfate transporter HH306_RS25700 ENOG4108ZK4 sdia-regulated domain-containing protein HH306_RS25720 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH306_RS25730 ENOG4105KT5 UmuD protein HH306_RS25735 ENOG4108RAV Conserved protein HH306_RS25810 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HH306_RS25920 ENOG4105X54 addiction module antidote protein HH306_RS25970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH306_RS25975 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HH306_RS25980 ENOG4105C34 Pseudouridine synthase HH306_RS25985 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HH306_RS25995 ENOG4107TUY Histidine kinase HH306_RS26000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS26005 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH306_RS26045 ENOG4106855 Competence protein HH306_RS26055 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HH306_RS26070 ENOG4105DTN riboflavin biosynthesis protein ribF HH306_RS26075 ENOG4105CJR Integral membrane protein (MviN HH306_RS26085 ENOG4108RH0 Crea protein HH306_RS26110 ENOG4105EAH synthase HH306_RS26125 ENOG4108V1T peptidylprolyl cis-trans isomerase HH306_RS26145 ENOG4105DAN ATP-dependent protease HH306_RS26170 ENOG4105CYB regulatoR HH306_RS26185 ENOG4105E0Y RtcB Protein HH306_RS26190 ENOG410756H nucleotidyltransferase HH306_RS26210 ENOG4105D82 Glutamate dehydrogenase HH306_RS26235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH306_RS26240 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH306_RS26245 ENOG4105C5H ABC transporter HH306_RS26255 ENOG4105RJZ Transcriptional regulator HH306_RS26260 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH306_RS26265 ENOG4105BZS acriflavin resistance protein HH306_RS26270 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH306_RS26275 ENOG4105RJZ Transcriptional regulator HH306_RS26280 ENOG4105BZU Histidine kinase HH306_RS26285 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HH306_RS26295 ENOG4105CKI cobalamin synthesis protein HH306_RS26300 ENOG4105VCD cytoplasmic protein HH306_RS26305 ENOG4105D22 carbon starvation protein HH306_RS26320 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HH306_RS26340 ENOG4105CH6 catalase HH306_RS26355 ENOG4105DP0 ferredoxin-NADP reductase HH306_RS26360 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HH306_RS26365 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HH306_RS26375 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HH306_RS26380 ENOG4107TJ9 Cytochrome HH306_RS26415 ENOG4105C5I Dehydrogenase HH306_RS26420 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HH306_RS26425 ENOG4108IQI permease HH306_RS26445 ENOG4108K0D peptidase, M48 HH306_RS26450 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS26455 ENOG4108RAV Conserved protein HH306_RS26460 ENOG4105KT7 mgtC SapB transporter HH306_RS26495 ENOG4105DWT malate dehydrogenase (quinone) HH306_RS26520 ENOG4108UGV hypoxanthine phosphoribosyltransferase HH306_RS26530 ENOG4105C2W permease HH306_RS26575 ENOG4105ECP epimerase HH306_RS26580 ENOG4108QDE fad dependent oxidoreductase HH306_RS26590 ENOG4108XDN Transcriptional regulator HH306_RS26595 ENOG4105CVP deoxyribo-dipyrimidine photolyase HH306_RS26600 ENOG41061N2 exported protein HH306_RS26610 ENOG4105D06 uba thif-type nad fad binding protein HH306_RS26615 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HH306_RS26630 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein HH306_RS26650 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HH306_RS26665 ENOG4105C3G gtp-binding protein HH306_RS26675 ENOG4105VDM plasmid maintenance system antidote protein, xre family HH306_RS26680 ENOG41080ET plasmid maintenance system killer protein HH306_RS26690 ENOG41077A9 carbonic anhydrase HH306_RS26700 ENOG410801F ribosomal-protein-alanine acetyltransferase HH306_RS26745 ENOG4107QKW extracellular solute-binding protein family 1 HH306_RS26750 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HH306_RS26755 ENOG4105DY2 Paraquat-inducible protein b HH306_RS26760 ENOG4105F1S paraquat-inducible protein a HH306_RS26765 ENOG4105H2K paraquat-inducible protein a HH306_RS26800 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HH306_RS26805 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HH306_RS26815 ENOG4108ZP8 Acetolactate synthase small subunit HH306_RS26820 ENOG4105C7K acetolactate synthase HH306_RS26835 ENOG4105WP7 tRNA pseudouridine synthase C HH306_RS26845 ENOG4105BZ4 penicillin-binding protein HH306_RS26875 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HH306_RS26880 ENOG4105EHG Permease protein HH306_RS26885 ENOG4107R4I Periplasmic binding protein HH306_RS26890 ENOG4106QJH hemin transport protein HH306_RS26895 ENOG4107ENK receptor HH306_RS26920 ENOG4105CHM Aminotransferase HH306_RS26930 ENOG4105CGZ zinc metallopeptidase HH306_RS26940 ENOG4105C7N Xanthine uracil vitamin C permease HH306_RS26975 ENOG4105BZU Histidine kinase HH306_RS26980 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS26985 ENOG4105DJ0 Poly(A) Polymerase HH306_RS26990 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HH306_RS27015 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH306_RS27040 ENOG4105VDW Csbd family HH306_RS27045 ENOG4105W4M Transport-associated protein HH306_RS27060 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HH306_RS27075 ENOG4105CHV Transcription elongation factor NusA HH306_RS27095 ENOG4107EJC Preprotein translocase subunit SecG HH306_RS27110 ENOG4105EEI dihydropteroate synthase HH306_RS27115 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HH306_RS27125 ENOG4105HBR Rna-binding protein HH306_RS27135 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HH306_RS27140 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HH306_RS27145 ENOG4108NIW Leucine export protein LeuE HH306_RS27150 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HH306_RS27175 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HH306_RS27180 ENOG41090R7 Ferric uptake HH306_RS27185 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HH306_RS27195 ENOG4108Z1B Cyclase dehydrase HH306_RS27205 ENOG41073TP transcriptional regulator HH306_RS27210 ENOG4105DAA L-lactate HH306_RS27230 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HH306_RS27240 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH306_RS27245 ENOG4105DHQ Histidine kinase HH306_RS27250 ENOG4108Z6Z Transcriptional regulator HH306_RS27260 ENOG4108594 Permease of the drug metabolite transporter HH306_RS27270 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HH306_RS27280 ENOG4105FDR Membrane HH306_RS27295 ENOG4105CHR reductase HH306_RS27300 ENOG4108ZX5 transcriptional regulator HH306_RS27315 ENOG4106371 Methyltransferase HH306_RS27345 ENOG4105PHD The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HH306_RS27350 ENOG4108MTT Glutamate-rich protein grpB HH306_RS27385 ENOG410839U amino acid HH306_RS27390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH306_RS27400 ENOG4105EM7 Selenocysteine-specific translation elongation factor HH306_RS27410 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HH306_RS27415 ENOG4108MG3 formate dehydrogenase HH306_RS27420 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HH306_RS27430 ENOG4107IFA Lipase (EC 3.1.1.3) HH306_RS27435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS27470 ENOG4107R73 Mate efflux family protein HH306_RS27480 ENOG4105EAM Na Pi-cotransporter HH306_RS27495 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HH306_RS27505 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HH306_RS27515 ENOG4107QN2 dihydrolipoyl dehydrogenase HH306_RS27530 ENOG4105EMU Dehydrogenase HH306_RS27535 ENOG4108UT2 hemolysin iii HH306_RS27540 ENOG4108I0N Transporter, RarD family, DMT superfamily protein HH306_RS27550 ENOG410642S Nicotianamine synthase protein HH306_RS27555 ENOG4105E0K tonB-dependent siderophore receptor HH306_RS27565 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HH306_RS27570 ENOG4108ZJT translation initiation factor, Sui1 HH306_RS27575 ENOG4105PTV Nudix Hydrolase HH306_RS27590 ENOG4108W2P Methyl-accepting chemotaxis HH306_RS27595 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HH306_RS27600 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HH306_RS27605 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HH306_RS27610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HH306_RS27630 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HH306_RS27635 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HH306_RS27645 ENOG4105C12 Phosphoribosylglycinamide synthetase HH306_RS27650 ENOG4105BZU Histidine kinase HH306_RS27655 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HH306_RS27660 ENOG41083Z3 extracellular ligand-binding receptor HH306_RS27665 ENOG4105C32 Amino acid ABC transporter (Permease) HH306_RS27670 ENOG4105CNN ABC, transporter HH306_RS27675 ENOG4105C0Z ABC transporter HH306_RS27680 ENOG4108IV0 ABC, transporter HH306_RS27690 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HH306_RS27700 ENOG4108Z7F N-acetyltransferase HH306_RS27710 ENOG4105CQM Urea amidohydrolase subunit alpha HH306_RS27720 ENOG4105KSC Transcriptional regulator, TraR DksA family HH306_RS27735 ENOG4105R8A Heat shock protein HH306_RS27760 ENOG4108Z6Z Transcriptional regulator HH306_RS27765 ENOG41066T0 asmA family HH306_RS27770 ENOG4108UQY Iron-storage protein HH306_RS27780 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HH306_RS27785 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) HH306_RS27845 ENOG4108S3W Anti-feci sigma factor, fecr HH306_RS27850 ENOG4108SF5 RNA Polymerase HH306_RS27860 ENOG41090KI Outer membrane porin HH306_RS27870 ENOG4105D2S major facilitator superfamily HH306_RS27875 ENOG4105FP9 thiamine pyrophosphate HH306_RS27880 ENOG4108PTX LysR family Transcriptional regulator HH306_RS27885 ENOG4105D2S major facilitator superfamily HH306_RS27905 ENOG4105EMU Dehydrogenase HH306_RS27910 ENOG4105CIF Ornithine Cyclodeaminase HH306_RS27915 ENOG4108IV0 ABC, transporter HH306_RS27920 ENOG4105C0Z ABC transporter HH306_RS27925 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HH306_RS27930 ENOG4105C32 Amino acid ABC transporter (Permease) HH306_RS27940 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS27955 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HH306_RS27965 ENOG4107RH7 Nicotinate phosphoribosyltransferase HH306_RS27980 ENOG41090JD Blue (Type 1) copper domain protein HH306_RS27985 ENOG4108URH decarboxylase HH306_RS27990 ENOG4108K5P (LipO)protein HH306_RS27995 ENOG4105D64 Mechanosensitive ion channel HH306_RS28010 ENOG4105CCT upf0313 protein HH306_RS28015 ENOG4105BZU Histidine kinase HH306_RS28020 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HH306_RS28025 ENOG4105CDU Replicative dna helicase HH306_RS28050 ENOG4105C2N RNA methyltransferase TrmH family group 3 HH306_RS28055 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HH306_RS28085 ENOG4105EPW hflc protein HH306_RS28090 ENOG4107QJR hflk protein HH306_RS28095 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HH306_RS28115 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HH306_RS28120 ENOG4105K8N protein family UPF0079, ATPase HH306_RS28125 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HH306_RS28130 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HH306_RS28135 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HH306_RS28140 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HH306_RS28145 ENOG4105ER2 Ompa motb domain protein HH306_RS28150 ENOG4107RD7 Flagellar Motor Protein, MotA HH306_RS28160 ENOG4105KHC sulfurtransferase HH306_RS28175 ENOG4105BZU Histidine kinase HH306_RS28180 ENOG4105EAC phosphoserine phosphatase HH306_RS28190 ENOG4105S2T inner membrane protein YbcI HH306_RS28200 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH306_RS28205 ENOG4108WIW Aspartyl protease HH306_RS28215 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH306_RS28220 ENOG4105IPS esterase HH306_RS28225 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HH306_RS28235 ENOG41087AY ADP-Ribose pyrophosphatase HH306_RS28250 ENOG4105DFG type I secretion outer membrane protein HH306_RS28255 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HH306_RS28260 ENOG4105CHM Aminotransferase HH306_RS28265 ENOG4105C7K acetolactate synthase HH306_RS28270 ENOG4105CMV Succinyl-CoA synthetase subunit beta HH306_RS28275 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS28280 ENOG4105E39 Enoyl-CoA hydratase HH306_RS28285 ENOG4108IQI permease HH306_RS28290 ENOG4105BZU Histidine kinase HH306_RS28300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HH306_RS28315 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH306_RS28325 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HH306_RS28330 ENOG4106P55 Transcriptional regulator HH306_RS28335 ENOG410814C multidrug resistance protein HH306_RS28340 ENOG41087SS fad dependent oxidoreductase HH306_RS28345 ENOG4107SET aldo keto reductase HH306_RS28355 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS28360 ENOG4105C1G acyl-Coa dehydrogenase HH306_RS28365 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HH306_RS28370 ENOG4105BZ1 (ABC) transporter HH306_RS28385 ENOG4108SHN Glycosyl transferase, family 2 HH306_RS28405 ENOG4107TAE Glycosyl transferase (Group 1 HH306_RS28430 ENOG4107543 (lipo)polysaccharide HH306_RS28435 ENOG4107RJ7 Glycosyl transferase (Group 1 HH306_RS28440 ENOG4105D16 lipopolysaccharide heptosyltransferase i HH306_RS28445 ENOG4105XA0 heptosyltransferase ii HH306_RS28450 ENOG4105CM2 brancheD-chain amino acid aminotransferase HH306_RS28455 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HH306_RS28460 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HH306_RS28465 ENOG4107QSN dihydrolipoamide acetyltransferase HH306_RS28470 ENOG4105BZU Histidine kinase HH306_RS28480 ENOG4105D6S protein involved in catabolism of external DNA HH306_RS28485 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS28490 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HH306_RS28495 ENOG4105EGS Mechanosensitive ion channel HH306_RS28505 ENOG410635A Membrane HH306_RS28525 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HH306_RS28530 ENOG4106NZI LysR family Transcriptional regulator HH306_RS28535 ENOG4105D94 Major Facilitator Superfamily HH306_RS28555 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HH306_RS28560 ENOG4105BZ8 glutamate synthase HH306_RS28585 ENOG4105E4G Type IV pilus HH306_RS28610 ENOG4108JQC penicillin-binding protein 1A HH306_RS28615 ENOG4105C6K Malic enzyme HH306_RS28635 ENOG4105C25 Primosomal protein n' HH306_RS28640 ENOG4105C75 arginyL-tRNA synthetase HH306_RS28710 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HH306_RS28745 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS28750 ENOG41067ZM Uncharacterised protein family (UPF0158) HH306_RS28755 ENOG4105CDA abc transporter atp-binding protein HH306_RS28760 ENOG4105E5Q amino acid AbC transporter HH306_RS28765 ENOG4106PMH Extracellular solute-binding protein family 3 HH306_RS28790 ENOG4108Z4K mutator MutT protein HH306_RS28795 ENOG4107RP9 extracellular solute-binding protein, family 3 HH306_RS28800 ENOG4105KME endoribonuclease L-psp HH306_RS28805 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH306_RS28830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HH306_RS28845 ENOG4105CI2 imidazolone-5-propionate hydrolase HH306_RS28850 ENOG4105C84 Histidine ammonia-lyase HH306_RS28855 ENOG4108IJ7 Glycine betaine HH306_RS28860 ENOG4108HQS Glycine betaine HH306_RS28870 ENOG4105C85 amino acid HH306_RS28880 ENOG4105ETS cytosine purines uracil thiamine allantoin HH306_RS28905 ENOG41090B9 response to stress HH306_RS28910 ENOG4105CZE histidine utilization repressor HH306_RS28915 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HH306_RS28940 ENOG4107XDR Lactoylglutathione lyase HH306_RS28945 ENOG4108FHP Autotransporter beta-domain HH306_RS28965 ENOG4108Z4X TRANSCRIPTIONal HH306_RS28970 ENOG4105CI3 gtp-binding protein typa HH306_RS28980 ENOG4105C5F glutamine synthetase HH306_RS28990 ENOG4105D8X mechanosensitive ion channel HH306_RS29005 ENOG4105CUX Signal transduction histidine kinase HH306_RS29010 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS29020 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HH306_RS29030 ENOG4105VW4 glutaredoxin 3 HH306_RS29040 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HH306_RS29050 ENOG41063SB peptidase HH306_RS29055 ENOG4105CN1 protease HH306_RS29060 ENOG4105PXI polysaccharide deacetylase HH306_RS29100 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HH306_RS29120 ENOG4105D5U fad dependent oxidoreductase HH306_RS29130 ENOG4105CEN a g-specific adenine glycosylase HH306_RS29140 ENOG4105D9R oxidoreductase HH306_RS29160 ENOG4106PGW Short-chain dehydrogenase reductase Sdr HH306_RS29170 ENOG4108JEH abc transporter atp-binding protein HH306_RS29175 ENOG4105E89 ABC transporter HH306_RS29195 ENOG4105K56 Transcriptional regulator HH306_RS29205 ENOG4105CW7 secretion protein, HlyD family HH306_RS29210 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH306_RS29220 ENOG4105C1B dTDP-glucose 4-6-dehydratase HH306_RS29225 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HH306_RS29235 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HH306_RS29240 ENOG4105CQZ Histidine kinase HH306_RS29245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS29250 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HH306_RS29255 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ HH306_RS29260 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HH306_RS29265 ENOG4105D5Q Arginine ornithine antiporter HH306_RS29270 ENOG4105CEU Arginine dihydrolase HH306_RS29275 ENOG4105DBV ornithine carbamoyltransferase HH306_RS29280 ENOG4105C5B carbamate kinase HH306_RS29285 ENOG4107RX2 synthase HH306_RS29300 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HH306_RS29305 ENOG4107RK2 ADP-ribose diphosphatase NudE HH306_RS29310 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HH306_RS29315 ENOG4109066 lysm domain bon superfamily protein HH306_RS29320 ENOG4105C5Q Transcriptional regulator HH306_RS29325 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HH306_RS29345 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HH306_RS29360 ENOG4105C0A alcohol dehydrogenase HH306_RS29365 ENOG4105CSU acyl-Coa dehydrogenase HH306_RS29370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH306_RS29405 ENOG4105VEJ Heat shock protein HH306_RS29410 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HH306_RS29420 ENOG4107WMG L,D-carboxypeptidase HH306_RS29425 ENOG4105E0F Histidine kinase HH306_RS29435 ENOG4105BZM domain protein HH306_RS29445 ENOG4105D9M gamma-glutamylcysteine synthetase HH306_RS29465 ENOG4105CJ3 phosphate transporter HH306_RS29470 ENOG4107IX6 phosphate transport regulator HH306_RS29475 ENOG4105I7R Adenylate cyclase HH306_RS29480 ENOG4107QHF type ii secretion system protein e HH306_RS29495 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HH306_RS29500 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HH306_RS29505 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HH306_RS29510 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HH306_RS29515 ENOG4107QKW extracellular solute-binding protein family 1 HH306_RS29520 ENOG4106NZI LysR family Transcriptional regulator HH306_RS29535 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HH306_RS29545 ENOG4105D0A hydroxylase HH306_RS29550 ENOG4107RAQ aminopeptidase HH306_RS29565 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HH306_RS29575 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HH306_RS29585 ENOG4105CMI transporter HH306_RS29590 ENOG4105CJ1 ABC, transporter HH306_RS29595 ENOG4105D0S secretion protein (HlyD HH306_RS29610 ENOG4105CXY transporter HH306_RS29625 ENOG4105EXC Acyl-transferase HH306_RS29630 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HH306_RS29635 ENOG4105K63 Thioredoxin HH306_RS29640 ENOG4105C9X ppx gppa phosphatase HH306_RS29650 ENOG4105D52 delta-aminolevulinic acid dehydratase HH306_RS29655 ENOG4105KHU inner membrane protein YohD HH306_RS29660 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HH306_RS29665 ENOG4108VUY thioesterase Superfamily protein HH306_RS29675 ENOG4107SJW iron permease, FTR1 HH306_RS29680 ENOG410829K Lysine exporter protein (Lyse ygga) HH306_RS29685 ENOG4105EE5 Membrane protein terC HH306_RS29695 ENOG4105C5H ABC transporter HH306_RS29715 ENOG4105PBF Anti-RNA polymerase sigma 70 factor HH306_RS29720 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HH306_RS29735 ENOG41076E6 Uroporphyrinogen-III Synthase HH306_RS29745 ENOG4108NEV two component transcriptional regulator, LytTR family HH306_RS29750 ENOG4108HRK Histidine kinase HH306_RS29775 ENOG4108WC9 type VI secretion system effector, hcp1 family HH306_RS29785 ENOG4107QUT magnesium and cobalt transport protein CorA HH306_RS29805 ENOG4107T0K Adenylate cyclase HH306_RS29815 ENOG4105NXH GreA GreB family elongation factor HH306_RS29825 ENOG4105XQ6 frataxin-like protein HH306_RS29835 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HH306_RS29850 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH306_RS29880 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HH306_RS29885 ENOG4105BZU Histidine kinase HH306_RS29890 ENOG4108YZA Nitrogen regulatory protein pii HH306_RS29895 ENOG4105W0Z cytoplasmic protein HH306_RS29900 ENOG4105C0P Mg chelatase subunit ChlI HH306_RS29905 ENOG4105C94 Transporter HH306_RS29915 ENOG4105ETT transcriptional Regulator, LysR family HH306_RS29920 ENOG4107QI1 Mate efflux family protein HH306_RS29925 ENOG4105BZU Histidine kinase HH306_RS29930 ENOG4105C4R Atp-dependent dna helicase HH306_RS29935 ENOG4105C7K acetolactate synthase HH306_RS29945 ENOG4105CYC Transferase HH306_RS29950 ENOG4105MPD Cytochrome HH306_RS29955 ENOG4107VRI Transcriptional regulator HH306_RS29960 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HH306_RS29965 ENOG4105M4H endoribonuclease L-psp HH306_RS29970 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH306_RS29980 ENOG410689M (LipO)protein HH306_RS29990 ENOG4105EW9 transcriptional regulator AsnC family HH306_RS29995 ENOG4105CJP fad dependent oxidoreductase HH306_RS30000 ENOG4107RZC phospholipase d HH306_RS30005 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH306_RS30010 ENOG4105C26 Dehydrogenase HH306_RS30015 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH306_RS30025 ENOG4105W0E 50S ribosomal protein L33 HH306_RS30035 ENOG4105DEF Extracellular solute-binding protein, family 5 HH306_RS30050 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HH306_RS30060 ENOG4107QKV phosphomannomutase HH306_RS30090 ENOG4105MPD Cytochrome HH306_RS30105 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HH306_RS30110 ENOG4105CGK Exodeoxyribonuclease III HH306_RS30125 ENOG4105DSJ YicC domain protein HH306_RS30130 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HH306_RS30140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH306_RS30145 ENOG4105KME endoribonuclease L-psp HH306_RS30160 ENOG4105EQD regulatoR HH306_RS30170 ENOG4105C5Q Transcriptional regulator HH306_RS30175 ENOG4105CB5 ATP-dependent DNA helicase recG HH306_RS30190 ENOG4105NYX DNA-binding protein HH306_RS30195 ENOG4107QZF nitrite reductase NADPH large subunit HH306_RS30200 ENOG4105VCQ rubredoxin HH306_RS30210 ENOG4108ZJF Glcg protein HH306_RS30215 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HH306_RS30220 ENOG4105EU8 FAD linked oxidase domain protein HH306_RS30225 ENOG4105CQB FAD linked oxidase domain protein HH306_RS30230 ENOG4108KWP DNA-binding transcriptional regulator GlcC HH306_RS30235 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HH306_RS30250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH306_RS30255 ENOG4105BZU Histidine kinase HH306_RS30260 ENOG4105C37 (CBS) domain HH306_RS30265 ENOG4105DR5 peptidase HH306_RS30270 ENOG4108VYJ response regulator receiver protein HH306_RS30275 ENOG4108UTW Plays a role in the regulation of phosphate uptake HH306_RS30280 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HH306_RS30285 ENOG4105C8U phosphate abc transporter HH306_RS30290 ENOG4105C8U phosphate abc transporter HH306_RS30295 ENOG4105DJH phosphate HH306_RS30325 ENOG4105CSH Transporter HH306_RS30330 ENOG4105NAU thioesterase Superfamily protein HH306_RS30350 ENOG4105C94 Transporter HH306_RS30355 ENOG4108IJ7 Glycine betaine HH306_RS30360 ENOG4108HQS Glycine betaine HH306_RS30370 ENOG4105EJQ L-serine dehydratase HH306_RS30375 ENOG4105ECQ AraC Family Transcriptional Regulator HH306_RS30385 ENOG4105DUM transcriptional regulator, lysR family HH306_RS30390 ENOG4105HMI Membrane HH306_RS30405 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HH306_RS30410 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HH306_RS30420 ENOG4105ECQ AraC Family Transcriptional Regulator HH306_RS30425 ENOG4105CWC Acetylornithine deacetylase HH306_RS30435 ENOG4105KME endoribonuclease L-psp HH306_RS30440 ENOG4105H3G oxidoreductase HH306_RS30455 ENOG4108IGT Dipeptidase HH306_RS30470 ENOG4105DF6 Fe-S oxidoreductase HH306_RS30490 ENOG4105VMP Transcriptional regulator HH306_RS30525 ENOG4105DVW rieske (2Fe-2S) HH306_RS30530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HH306_RS30540 ENOG4105C5W Aldolase HH306_RS30550 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HH306_RS30580 ENOG4105E2A Dehydrogenase HH306_RS30585 ENOG4105DSB aldose 1-epimerase HH306_RS30600 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HH306_RS30605 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HH306_RS30615 ENOG4107YNJ LysR family Transcriptional regulator HH306_RS30620 ENOG4108IJ0 Aspartate ammonia-lyase HH306_RS30625 ENOG41066VF YeeE YedE family protein HH306_RS30650 ENOG4107QSA Oxaloacetate decarboxylase HH306_RS30655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HH306_RS30670 ENOG4106KNT transcriptional regulator HH306_RS30675 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HH306_RS30680 ENOG4105CFP Peptidase U32 HH306_RS30695 ENOG4105BZU Histidine kinase HH306_RS30700 ENOG4105C4R Atp-dependent dna helicase HH306_RS30710 ENOG4105CYC Transferase HH306_RS30725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH306_RS30735 ENOG4105EY8 ABC transporter HH306_RS30750 ENOG4105C0K Gdp-mannose 4,6-dehydratase HH306_RS30755 ENOG4108DMA Nad-dependent epimerase dehydratase HH306_RS30770 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HH306_RS30775 ENOG4105EXC Acyl-transferase HH306_RS30815 ENOG4105RK9 auxin efflux carrier HH306_RS30825 ENOG4105D4T Citrate transporter HH306_RS30830 ENOG4105EE5 Membrane protein terC HH306_RS30835 ENOG4108S2Y peptide Chain Release factor HH306_RS30850 ENOG4105EAM Na Pi-cotransporter HH306_RS30860 ENOG41090JX gCN5-related N-acetyltransferase HH306_RS30880 ENOG4105CK2 sodium dicarboxylate symporter HH306_RS30885 ENOG4108ZGU inhibitor of vertebrate lysozyme HH306_RS30895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS30900 ENOG4105ES5 Histidine kinase HH306_RS30905 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HH306_RS30910 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HH306_RS30925 ENOG4108Z33 Thiol disulfide Interchange Protein HH306_RS30930 ENOG4106RE7 Cytochrome HH306_RS30935 ENOG4105MPD Cytochrome HH306_RS30945 ENOG4105C2M dna polymerase I HH306_RS30970 ENOG4105NXV High-affinity zinc uptake system protein HH306_RS30975 ENOG4105MYN Zinc uptake regulation protein HH306_RS30985 ENOG4105FAV ABC, transporter HH306_RS31000 ENOG4108UMI ABC transporter, permease HH306_RS31005 ENOG4105D01 (LipO)protein HH306_RS31030 ENOG4105CUB amino acid HH306_RS31035 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH306_RS31050 ENOG4108HWY Beta-lactamase HH306_RS31075 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH306_RS31080 ENOG4108S4H thioesterase Superfamily protein HH306_RS31090 ENOG4105CHR reductase HH306_RS31095 ENOG4105CFQ glutamine synthetase HH306_RS31100 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HH306_RS31105 ENOG4105CHR reductase HH306_RS31130 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH306_RS31135 ENOG4105CSH Transporter HH306_RS31140 ENOG410822N TonB family HH306_RS31145 ENOG4105CKI cobalamin synthesis protein HH306_RS31175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HH306_RS31190 ENOG4105CD3 dihydroorotase HH306_RS31210 ENOG4105H1G trap transporter solute receptor taxi family HH306_RS31215 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HH306_RS31230 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HH306_RS31235 ENOG410804X Transcriptional regulator HH306_RS31280 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HH306_RS31290 ENOG41064MJ ATP synthase, subunit I HH306_RS31295 ENOG4105FA0 parb-like partition protein HH306_RS31300 ENOG4107QJE Chromosome Partitioning Protein HH306_RS31320 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HH306_RS31470 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HH306_RS31585 ENOG4105W1Y Transcriptional regulator HH306_RS31590 ENOG4105D25 secreted protein HH306_RS31610 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity HH306_RS31615 ENOG4105EDF drug resistance transporter, EmrB QacA subfamily HH306_RS31630 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS31635 ENOG4105C8Q Methyl-accepting chemotaxis HH306_RS31640 ENOG4108IV0 ABC, transporter HH306_RS31645 ENOG4105C0Z ABC transporter HH306_RS31725 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH306_RS31735 ENOG41088T4 Helicase IV HH306_RS31785 ENOG4105CFI type iii restriction protein res subunit HH306_RS31800 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HH306_RS31835 ENOG4108KU3 Integrase HH306_RS31865 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) HH306_RS31870 ENOG4107QJE Chromosome Partitioning Protein HH306_RS31985 ENOG4105FA0 parb-like partition protein HH306_RS31990 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HH306_RS32125 ENOG4108UUM single-stranded DNA-binding protein