locus-tag	class	description
HW02_RS00040	COG0765	amino acid transport
HW02_RS00050	COG1126	abc transporter atp-binding protein
HW02_RS00075	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS00090	COG1253	flavin adenine dinucleotide binding
HW02_RS00095	COG0300	oxidoreductase activity
HW02_RS00105	COG0583	DNA-binding transcription factor activity
HW02_RS00110	COG3591	Belongs to the peptidase S1B family
HW02_RS00110	COG1864	DNA RNA non-specific endonuclease
HW02_RS00115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW02_RS00120	COG4319	ketosteroid isomerase
HW02_RS00135	COG4774	siderophore transport
HW02_RS00180	COG2814	Major facilitator Superfamily
HW02_RS00200	COG0583	DNA-binding transcription factor activity
HW02_RS00210	COG0121	glutamine amidotransferase
HW02_RS00240	COG3712	iron ion homeostasis
HW02_RS00245	COG1595	DNA-templated transcription, initiation
HW02_RS00260	COG1230	cation diffusion facilitator family transporter
HW02_RS00265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW02_RS00290	COG2252	PERMEase
HW02_RS00350	COG2233	PERMEase
HW02_RS00365	COG1309	transcriptional regulator
HW02_RS00375	COG3960	tartronate-semialdehyde synthase activity
HW02_RS00380	COG3622	Belongs to the hyi family
HW02_RS00385	COG2084	Dehydrogenase
HW02_RS00395	COG0469	pyruvate kinase activity
HW02_RS00400	COG4413	Urea transporter
HW02_RS00405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW02_RS00430	COG3192	ethanolamine utilization protein
HW02_RS00445	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS00450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HW02_RS00525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW02_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS00545	COG1496	oxidoreductase activity
HW02_RS00570	COG0835	chemotaxis
HW02_RS00580	COG1192	Involved in chromosome partitioning
HW02_RS00585	COG1360	Flagellar Motor Protein
HW02_RS00590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW02_RS00600	COG0643	Histidine kinase
HW02_RS00600	COG0784	Response regulator, receiver
HW02_RS00600	COG2198	Histidine kinase
HW02_RS00630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW02_RS00635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW02_RS00655	COG1987	bacterial-type flagellum assembly
HW02_RS00695	COG2832	Protein of unknown function (DUF454)
HW02_RS00710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS00715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS00725	COG3300	MHYT domain
HW02_RS00725	COG5001	Diguanylate cyclase
HW02_RS00770	COG0488	(ABC) transporter
HW02_RS00825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS00830	COG0583	DNA-binding transcription factor activity
HW02_RS00845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW02_RS00855	COG3264	Mechanosensitive ion channel
HW02_RS00855	COG1196	nuclear chromosome segregation
HW02_RS00860	COG0116	Belongs to the methyltransferase superfamily
HW02_RS00860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW02_RS00870	COG0210	DNA helicase
HW02_RS00895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW02_RS00940	COG0438	transferase activity, transferring glycosyl groups
HW02_RS00945	COG0463	Glycosyl transferase, family 2
HW02_RS00950	COG0438	transferase activity, transferring glycosyl groups
HW02_RS00975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW02_RS00985	COG1450	Type ii and iii secretion system protein
HW02_RS01035	COG1960	acyl-CoA dehydrogenase activity
HW02_RS01055	COG0406	alpha-ribazole phosphatase activity
HW02_RS01085	COG0778	Nitroreductase
HW02_RS01100	COG4206	TonB-dependent receptor
HW02_RS01110	COG1802	Transcriptional regulator
HW02_RS01120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS01150	COG0477	Major facilitator Superfamily
HW02_RS01170	COG0765	amino acid transport
HW02_RS01180	COG1126	abc transporter atp-binding protein
HW02_RS01190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS01195	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS01245	COG4191	Histidine kinase
HW02_RS01245	COG0784	Response regulator, receiver
HW02_RS01285	COG1289	transmembrane transporter activity
HW02_RS01300	COG2207	Transcriptional regulator
HW02_RS01320	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS01325	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS01335	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HW02_RS01360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW02_RS01370	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS01375	COG0367	asparagine synthase
HW02_RS01385	COG2211	Major facilitator Superfamily
HW02_RS01435	COG1335	isochorismatase
HW02_RS01440	COG0583	DNA-binding transcription factor activity
HW02_RS01450	COG0791	NLP P60 protein
HW02_RS01455	COG0791	NLP P60 protein
HW02_RS01465	COG3829	transcription factor binding
HW02_RS01480	COG2818	Glycosylase
HW02_RS01505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW02_RS01510	COG1960	acyl-CoA dehydrogenase activity
HW02_RS01520	COG0625	glutathione transferase activity
HW02_RS01540	COG5001	Diguanylate cyclase
HW02_RS01540	COG3447	MASE1 domain protein
HW02_RS01540	COG5002	protein histidine kinase activity
HW02_RS01560	COG4459	periplasmic nitrate reductase
HW02_RS01565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW02_RS01565	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW02_RS01570	COG3062	negative regulation of establishment of protein localization
HW02_RS01580	COG3043	anaerobic respiration
HW02_RS01585	COG3005	denitrification pathway
HW02_RS01590	COG2951	lytic endotransglycosylase activity
HW02_RS01595	COG0861	Integral membrane protein TerC family
HW02_RS01600	COG0753	catalase activity
HW02_RS01620	COG2977	Belongs to the P-Pant transferase superfamily
HW02_RS01625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW02_RS01640	COG2226	methyltransferase
HW02_RS01655	COG2205	protein histidine kinase activity
HW02_RS01660	COG0745	RESPONSE REGULATOR receiver
HW02_RS01665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW02_RS01665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW02_RS01670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW02_RS01675	COG1943	Transposase
HW02_RS01700	COG4104	PAAR repeat-containing protein
HW02_RS01715	COG0531	amino acid
HW02_RS01745	COG0583	DNA-binding transcription factor activity
HW02_RS01750	COG3257	ureidoglycine aminohydrolase activity
HW02_RS01765	COG3321	synthase
HW02_RS01765	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS01765	COG0604	alcohol dehydrogenase
HW02_RS01770	COG2197	response regulator
HW02_RS01810	COG0583	DNA-binding transcription factor activity
HW02_RS01815	COG0667	Aldo Keto reductase
HW02_RS01840	COG0242	peptide deformylase activity
HW02_RS01850	COG2199	diguanylate cyclase activity
HW02_RS01855	COG2885	chlorophyll binding
HW02_RS01885	COG1132	(ABC) transporter
HW02_RS01895	COG4628	conserved protein (DUF2132)
HW02_RS01900	COG2133	pyrroloquinoline quinone binding
HW02_RS01915	COG2207	Transcriptional regulator
HW02_RS01920	COG0477	Major facilitator Superfamily
HW02_RS01935	COG2882	bacterial-type flagellum organization
HW02_RS01990	COG1516	flagellar protein fliS
HW02_RS01995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW02_RS02005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW02_RS02010	COG1216	Glycosyl transferase, family 2
HW02_RS02010	COG0438	transferase activity, transferring glycosyl groups
HW02_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS02040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW02_RS02085	COG4787	bacterial-type flagellum-dependent cell motility
HW02_RS02095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW02_RS02105	COG1815	bacterial-type flagellum-dependent cell motility
HW02_RS02150	COG0326	Molecular chaperone. Has ATPase activity
HW02_RS02165	COG3189	MarR family transcriptional regulator
HW02_RS02185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW02_RS02200	COG2212	antiporter activity
HW02_RS02205	COG1863	multisubunit Na H antiporter MnhE subunit
HW02_RS02210	COG0651	ATP synthesis coupled electron transport
HW02_RS02215	COG1006	Multisubunit Na H antiporter MnhC subunit
HW02_RS02220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW02_RS02220	COG2111	Na H antiporter
HW02_RS02225	COG3133	Outer membrane lipoprotein
HW02_RS02235	COG1929	Belongs to the glycerate kinase type-1 family
HW02_RS02240	COG2610	gluconate transmembrane transporter activity
HW02_RS02245	COG3835	regulator
HW02_RS02255	COG2885	chlorophyll binding
HW02_RS02270	COG1199	ATP-dependent helicase activity
HW02_RS02310	COG2860	membrane
HW02_RS02325	COG0653	protein targeting
HW02_RS02330	COG0625	glutathione transferase activity
HW02_RS02355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS02360	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS02385	COG1960	acyl-CoA dehydrogenase activity
HW02_RS02390	COG1024	Enoyl-CoA hydratase
HW02_RS02395	COG1960	acyl-CoA dehydrogenase activity
HW02_RS02405	COG2814	Major facilitator Superfamily
HW02_RS02410	COG2030	dehydratase
HW02_RS02420	COG0183	Belongs to the thiolase family
HW02_RS02450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW02_RS02455	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HW02_RS02470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW02_RS02480	COG0425	Belongs to the sulfur carrier protein TusA family
HW02_RS02535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW02_RS02560	COG1051	belongs to the nudix hydrolase family
HW02_RS02575	COG1192	Involved in chromosome partitioning
HW02_RS02685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS02720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS02825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW02_RS02835	COG1074	ATP-dependent DNA helicase activity
HW02_RS02880	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS02890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW02_RS02895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS02920	COG2963	transposase activity
HW02_RS02925	COG2801	Transposase and inactivated derivatives
HW02_RS03090	COG3609	addiction module antidote protein, CC2985 family
HW02_RS03125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HW02_RS03140	COG0602	queuosine metabolic process
HW02_RS03145	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HW02_RS03175	COG0824	Thioesterase
HW02_RS03205	COG0783	Belongs to the Dps family
HW02_RS03255	COG3118	belongs to the thioredoxin family
HW02_RS03290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW02_RS03305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW02_RS03355	COG3122	Protein conserved in bacteria
HW02_RS03365	COG3956	TIGRFAM MazG family protein
HW02_RS03370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW02_RS03400	COG5002	protein histidine kinase activity
HW02_RS03400	COG2205	protein histidine kinase activity
HW02_RS03400	COG0784	Response regulator, receiver
HW02_RS03405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW02_RS03455	COG3038	cytochrome b561
HW02_RS03470	COG4807	Protein conserved in bacteria
HW02_RS03480	COG2239	Acts as a magnesium transporter
HW02_RS03550	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HW02_RS03645	COG2301	Belongs to the HpcH HpaI aldolase family
HW02_RS03655	COG2079	MmgE PrpD family protein
HW02_RS03665	COG1960	acyl-CoA dehydrogenase activity
HW02_RS03670	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HW02_RS03675	COG0583	DNA-binding transcription factor activity
HW02_RS03680	COG0583	DNA-binding transcription factor activity
HW02_RS03730	COG1113	amino acid transport
HW02_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS03750	COG0604	alcohol dehydrogenase
HW02_RS03750	COG3321	synthase
HW02_RS03780	COG0271	Belongs to the BolA IbaG family
HW02_RS03820	COG0492	ferredoxin-NADP+ reductase activity
HW02_RS03825	COG0450	alkyl hydroperoxide reductase
HW02_RS03860	COG1307	EDD domain protein, DegV family
HW02_RS03870	COG1309	transcriptional regulator
HW02_RS03875	COG0386	Belongs to the glutathione peroxidase family
HW02_RS03895	COG0204	Acyl-transferase
HW02_RS03900	COG2885	chlorophyll binding
HW02_RS03905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS03920	COG2267	carboxylic ester hydrolase activity
HW02_RS03985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW02_RS04000	COG0546	phosphoglycolate phosphatase activity
HW02_RS04015	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW02_RS04030	COG0656	L-ascorbic acid biosynthetic process
HW02_RS04055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS04065	COG1802	Transcriptional regulator
HW02_RS04075	COG0372	Belongs to the citrate synthase family
HW02_RS04090	COG2079	MmgE PrpD family protein
HW02_RS04105	COG1113	amino acid transport
HW02_RS04135	COG0583	DNA-binding transcription factor activity
HW02_RS04140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW02_RS04150	COG4206	TonB-dependent receptor
HW02_RS04160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW02_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW02_RS04305	COG3180	Ammonia monooxygenase
HW02_RS04315	COG2720	vancomycin resistance protein
HW02_RS04330	COG1960	acyl-CoA dehydrogenase activity
HW02_RS04335	COG1024	Enoyl-CoA hydratase
HW02_RS04360	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW02_RS04430	COG0582	viral genome integration into host DNA
HW02_RS04435	COG0789	Transcriptional regulator
HW02_RS04445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW02_RS04505	COG2003	Belongs to the UPF0758 family
HW02_RS04575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS04595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS04630	COG3621	Patatin-like phospholipase
HW02_RS04750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS04815	COG0583	DNA-binding transcription factor activity
HW02_RS04825	COG0583	DNA-binding transcription factor activity
HW02_RS04845	COG0071	Belongs to the small heat shock protein (HSP20) family
HW02_RS04850	COG0542	response to heat
HW02_RS04860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW02_RS04865	COG3118	belongs to the thioredoxin family
HW02_RS04880	COG0501	Belongs to the peptidase M48B family
HW02_RS04885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW02_RS04905	COG0789	Transcriptional regulator
HW02_RS04915	COG0583	DNA-binding transcription factor activity
HW02_RS04930	COG4974	Belongs to the 'phage' integrase family
HW02_RS04940	COG4128	Pfam Zonular occludens toxin
HW02_RS05020	COG0583	DNA-binding transcription factor activity
HW02_RS05035	COG0463	Glycosyl transferase, family 2
HW02_RS05040	COG0154	amidase activity
HW02_RS05060	COG0583	DNA-binding transcription factor activity
HW02_RS05070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS05105	COG2831	hemolysin activation secretion protein
HW02_RS05260	COG0420	3'-5' exonuclease activity
HW02_RS05270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW02_RS05275	COG1074	ATP-dependent DNA helicase activity
HW02_RS05280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HW02_RS05285	COG0095	Lipoate-protein ligase
HW02_RS05290	COG0697	spore germination
HW02_RS05315	COG0306	phosphate transporter
HW02_RS05375	COG4964	Belongs to the GSP D family
HW02_RS05395	COG0433	COG0433 Predicted ATPase
HW02_RS05430	COG0788	formyltetrahydrofolate deformylase activity
HW02_RS05440	COG2925	Exonuclease
HW02_RS05470	COG0714	Associated with various cellular activities
HW02_RS05500	COG0589	response to stress
HW02_RS05510	COG1024	Enoyl-CoA hydratase
HW02_RS05520	COG3706	GGDEF domain
HW02_RS05540	COG0693	protein deglycase activity
HW02_RS05555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW02_RS05570	COG0154	amidase activity
HW02_RS05580	COG1473	amidohydrolase
HW02_RS05595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW02_RS05600	COG0426	domain, Protein
HW02_RS05600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW02_RS05620	COG0589	response to stress
HW02_RS05635	COG2814	Major facilitator Superfamily
HW02_RS05640	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS05655	COG1918	ferrous iron import across plasma membrane
HW02_RS05670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW02_RS05710	COG1704	LemA family
HW02_RS05735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS05740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS05755	COG3642	lipopolysaccharide core region biosynthetic process
HW02_RS05765	COG2205	protein histidine kinase activity
HW02_RS05770	COG0745	RESPONSE REGULATOR receiver
HW02_RS05805	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW02_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS05840	COG0668	transmembrane transport
HW02_RS05850	COG0745	RESPONSE REGULATOR receiver
HW02_RS05865	COG2096	Adenosyltransferase
HW02_RS05870	COG0494	nUDIX hydrolase
HW02_RS05890	COG0741	lytic transglycosylase activity
HW02_RS05890	COG0739	heme binding
HW02_RS05890	COG1196	nuclear chromosome segregation
HW02_RS05935	COG0772	Belongs to the SEDS family
HW02_RS05950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW02_RS05990	COG3107	peptidoglycan biosynthetic process
HW02_RS06005	COG2823	Periplasmic or secreted lipoprotein
HW02_RS06010	COG2969	positive regulation of protein catabolic process
HW02_RS06015	COG0625	glutathione transferase activity
HW02_RS06020	COG2857	Cytochrome c1
HW02_RS06025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW02_RS06030	COG0723	plastoquinol--plastocyanin reductase activity
HW02_RS06045	COG0667	Aldo Keto reductase
HW02_RS06050	COG1960	acyl-CoA dehydrogenase activity
HW02_RS06065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW02_RS06075	COG2945	thiolester hydrolase activity
HW02_RS06095	COG2951	lytic endotransglycosylase activity
HW02_RS06105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW02_RS06145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW02_RS06150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW02_RS06155	COG1127	ABC transporter
HW02_RS06165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HW02_RS06180	COG1137	ATPase activity
HW02_RS06235	COG0312	modulator of DNA gyrase
HW02_RS06245	COG0312	modulator of DNA gyrase
HW02_RS06250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW02_RS06260	COG1530	ribonuclease E activity
HW02_RS06275	COG1792	Involved in formation and maintenance of cell shape
HW02_RS06280	COG1077	Cell shape determining protein MreB Mrl
HW02_RS06300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW02_RS06305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS06310	COG4676	Protein conserved in bacteria
HW02_RS06315	COG5445	Predicted secreted protein (DUF2300)
HW02_RS06330	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HW02_RS06335	COG4676	Protein conserved in bacteria
HW02_RS06340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HW02_RS06355	COG0747	negative chemotaxis
HW02_RS06360	COG0747	negative chemotaxis
HW02_RS06375	COG0747	negative chemotaxis
HW02_RS06385	COG0747	negative chemotaxis
HW02_RS06390	COG0601	transmembrane transport
HW02_RS06395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW02_RS06400	COG0444	Belongs to the ABC transporter superfamily
HW02_RS06405	COG4608	Belongs to the ABC transporter superfamily
HW02_RS06420	COG1984	allophanate hydrolase subunit 2
HW02_RS06440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW02_RS06445	COG4774	siderophore transport
HW02_RS06460	COG2194	sulfuric ester hydrolase activity
HW02_RS06470	COG0019	diaminopimelate decarboxylase activity
HW02_RS06510	COG4969	Belongs to the N-Me-Phe pilin family
HW02_RS06585	COG1252	NADH dehydrogenase
HW02_RS06590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW02_RS06605	COG1192	Involved in chromosome partitioning
HW02_RS06740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS06745	COG1278	Cold shock
HW02_RS06755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS06765	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW02_RS06770	COG3657	addiction module killer protein
HW02_RS06795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS06940	COG1074	ATP-dependent DNA helicase activity
HW02_RS07055	COG3609	addiction module antidote protein, CC2985 family
HW02_RS07070	COG3328	transposase activity
HW02_RS07080	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HW02_RS07145	COG4969	Belongs to the N-Me-Phe pilin family
HW02_RS07185	COG1047	Peptidyl-prolyl cis-trans
HW02_RS07200	COG0196	riboflavin kinase activity
HW02_RS07215	COG3045	CreA protein
HW02_RS07240	COG0142	geranyltranstransferase activity
HW02_RS07255	COG0545	Peptidyl-prolyl cis-trans isomerase
HW02_RS07275	COG1067	ATP-dependent peptidase activity
HW02_RS07300	COG4650	regulator
HW02_RS07315	COG1690	Belongs to the RtcB family
HW02_RS07320	COG3541	Predicted nucleotidyltransferase
HW02_RS07340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW02_RS07365	COG0577	efflux transmembrane transporter activity
HW02_RS07365	COG1136	(ABC) transporter
HW02_RS07370	COG0577	efflux transmembrane transporter activity
HW02_RS07370	COG1136	(ABC) transporter
HW02_RS07375	COG0488	(ABC) transporter
HW02_RS07395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS07400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS07450	COG0523	cobalamin synthesis protein
HW02_RS07455	COG2879	small protein
HW02_RS07460	COG1966	Carbon starvation protein
HW02_RS07535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW02_RS07535	COG3608	succinylglutamate desuccinylase aspartoacylase
HW02_RS07540	COG2010	Cytochrome c
HW02_RS07575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW02_RS07585	COG0833	amino acid
HW02_RS07590	COG2119	membrane
HW02_RS07605	COG0501	Belongs to the peptidase M48B family
HW02_RS07610	COG0840	transmembrane signaling receptor activity
HW02_RS07615	COG2135	peptidase activity
HW02_RS07620	COG1285	pathogenesis
HW02_RS07680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW02_RS07735	COG1090	epimerase
HW02_RS07740	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HW02_RS07750	COG0789	Transcriptional regulator
HW02_RS07770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW02_RS07825	COG0012	GTP binding
HW02_RS07830	COG0582	viral genome integration into host DNA
HW02_RS07840	COG1111	helicase
HW02_RS07840	COG1205	dead DEAH box helicase
HW02_RS07845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS07875	COG4974	Belongs to the 'phage' integrase family
HW02_RS07960	COG0288	reversible hydration of carbon dioxide
HW02_RS07970	COG0456	acetyltransferase
HW02_RS08015	COG1840	ABC-type Fe3 transport system, periplasmic component
HW02_RS08020	COG1178	ABC-type Fe3 transport system permease component
HW02_RS08025	COG3008	intermembrane lipid transfer
HW02_RS08030	COG2995	paraquat-inducible protein a
HW02_RS08035	COG2995	paraquat-inducible protein a
HW02_RS08075	COG1183	phosphatidylcholine synthase activity
HW02_RS08090	COG0028	Belongs to the TPP enzyme family
HW02_RS08100	COG3098	single-species biofilm formation
HW02_RS08110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW02_RS08145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS08150	COG4558	Periplasmic binding protein
HW02_RS08155	COG3720	iron ion transport
HW02_RS08160	COG4771	TonB-dependent receptor
HW02_RS08185	COG0436	Aminotransferase
HW02_RS08195	COG2321	neutral zinc metallopeptidase
HW02_RS08205	COG2252	PERMEase
HW02_RS08220	COG0436	Aminotransferase
HW02_RS08225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW02_RS08240	COG4191	Histidine kinase
HW02_RS08340	COG0195	Participates in both transcription termination and antitermination
HW02_RS08375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW02_RS08440	COG0497	DNA recombination
HW02_RS08470	COG2186	Transcriptional regulator
HW02_RS08475	COG1620	l-lactate permease
HW02_RS08525	COG0697	spore germination
HW02_RS08545	COG0697	spore germination
HW02_RS08550	COG1522	sequence-specific DNA binding
HW02_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS08580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW02_RS08610	COG0509	glycine decarboxylation via glycine cleavage system
HW02_RS08650	COG0531	amino acid
HW02_RS08665	COG3276	selenocysteine insertion sequence binding
HW02_RS08680	COG2864	formate dehydrogenase
HW02_RS08685	COG0437	4 iron, 4 sulfur cluster binding
HW02_RS08690	COG3383	formate dehydrogenase (NAD+) activity
HW02_RS08690	COG0243	molybdopterin cofactor binding
HW02_RS08695	COG3383	formate dehydrogenase (NAD+) activity
HW02_RS08695	COG0243	molybdopterin cofactor binding
HW02_RS08700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HW02_RS08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS08705	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS08730	COG0463	Glycosyl transferase, family 2
HW02_RS08740	COG0534	Mate efflux family protein
HW02_RS08750	COG1283	sodium-dependent phosphate transmembrane transporter activity
HW02_RS08775	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HW02_RS08800	COG4221	oxidoreductase activity
HW02_RS08805	COG1272	protein, Hemolysin III
HW02_RS08840	COG0023	Translation Initiation Factor
HW02_RS08925	COG2095	MarC family integral membrane protein
HW02_RS08930	COG0683	leucine binding
HW02_RS08945	COG0411	ABC transporter
HW02_RS08990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW02_RS09005	COG0443	Heat shock 70 kDa protein
HW02_RS09030	COG0789	Transcriptional regulator
HW02_RS09035	COG2982	Protein involved in outer membrane biogenesis
HW02_RS09040	COG2193	ferroxidase activity
HW02_RS09050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW02_RS09055	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HW02_RS09115	COG3712	iron ion homeostasis
HW02_RS09120	COG1595	DNA-templated transcription, initiation
HW02_RS09140	COG2814	Major facilitator Superfamily
HW02_RS09150	COG0583	DNA-binding transcription factor activity
HW02_RS09175	COG4221	oxidoreductase activity
HW02_RS09180	COG2423	ornithine cyclodeaminase activity
HW02_RS09210	COG0583	DNA-binding transcription factor activity
HW02_RS09225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW02_RS09265	COG0668	transmembrane transport
HW02_RS09285	COG3300	MHYT domain
HW02_RS09285	COG5001	Diguanylate cyclase
HW02_RS09295	COG0305	Participates in initiation and elongation during chromosome replication
HW02_RS09325	COG0557	exoribonuclease II activity
HW02_RS09355	COG0330	HflC and HflK could
HW02_RS09360	COG0330	HflC and HflK could
HW02_RS09365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW02_RS09385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW02_RS09390	COG0802	atpase or kinase
HW02_RS09395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW02_RS09395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW02_RS09445	COG3300	MHYT domain
HW02_RS09445	COG5001	Diguanylate cyclase
HW02_RS09450	COG0560	Phosphoserine phosphatase
HW02_RS09450	COG3830	Belongs to the UPF0237 family
HW02_RS09460	COG1988	membrane-bound metal-dependent
HW02_RS09475	COG3577	Aspartyl protease
HW02_RS09490	COG3150	esterase
HW02_RS09495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HW02_RS09505	COG0494	nUDIX hydrolase
HW02_RS09520	COG1538	Outer membrane efflux protein
HW02_RS09525	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS09540	COG0045	succinate-CoA ligase (ADP-forming) activity
HW02_RS09545	COG1960	acyl-CoA dehydrogenase activity
HW02_RS09550	COG1024	Enoyl-CoA hydratase
HW02_RS09555	COG0833	amino acid
HW02_RS09585	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS09585	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS09595	COG1519	Transferase
HW02_RS09600	COG0583	DNA-binding transcription factor activity
HW02_RS09615	COG0667	Aldo Keto reductase
HW02_RS09625	COG1960	acyl-CoA dehydrogenase activity
HW02_RS09630	COG1960	acyl-CoA dehydrogenase activity
HW02_RS09640	COG0367	asparagine synthase
HW02_RS09665	COG1215	transferase activity, transferring glycosyl groups
HW02_RS09685	COG0438	transferase activity, transferring glycosyl groups
HW02_RS09690	COG2192	nodulation
HW02_RS09715	COG0438	transferase activity, transferring glycosyl groups
HW02_RS09720	COG0859	PFAM glycosyl transferase family 9
HW02_RS09725	COG0859	PFAM glycosyl transferase family 9
HW02_RS09760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HW02_RS09765	COG1960	acyl-CoA dehydrogenase activity
HW02_RS09775	COG1196	nuclear chromosome segregation
HW02_RS09775	COG3264	Mechanosensitive ion channel
HW02_RS09785	COG0730	response to heat
HW02_RS09790	COG2873	o-acetylhomoserine
HW02_RS09805	COG1192	Involved in chromosome partitioning
HW02_RS09810	COG0583	DNA-binding transcription factor activity
HW02_RS09815	COG2814	Major facilitator Superfamily
HW02_RS09840	COG0493	'glutamate synthase
HW02_RS09845	COG0070	glutamate synthase
HW02_RS09845	COG0069	glutamate synthase activity
HW02_RS09845	COG0067	glutamate synthase
HW02_RS09895	COG0281	malic enzyme
HW02_RS09915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW02_RS10025	COG0840	transmembrane signaling receptor activity
HW02_RS10035	COG1126	abc transporter atp-binding protein
HW02_RS10040	COG0765	amino acid transport
HW02_RS10070	COG1051	belongs to the nudix hydrolase family
HW02_RS10075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS10080	COG0251	oxidation-reduction process
HW02_RS10125	COG2986	histidine ammonia-lyase
HW02_RS10130	COG4175	Glycine betaine
HW02_RS10135	COG4176	ABC-type proline glycine betaine transport system permease component
HW02_RS10155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW02_RS10190	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS10240	COG0789	Transcriptional regulator
HW02_RS10245	COG1217	gtp-binding protein TYPA
HW02_RS10265	COG0668	transmembrane transport
HW02_RS10280	COG3852	Histidine kinase
HW02_RS10295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW02_RS10325	COG4942	peptidase
HW02_RS10330	COG0793	Belongs to the peptidase S41A family
HW02_RS10335	COG2861	carbohydrate metabolic process
HW02_RS10395	COG0579	oxidoreductase
HW02_RS10405	COG1194	a g-specific adenine glycosylase
HW02_RS10415	COG0673	inositol 2-dehydrogenase activity
HW02_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS10505	COG1566	PFAM secretion protein HlyD family protein
HW02_RS10510	COG2814	Major facilitator Superfamily
HW02_RS10520	COG1088	dTDP-glucose 4,6-dehydratase activity
HW02_RS10525	COG1091	dTDP-4-dehydrorhamnose reductase activity
HW02_RS10590	COG1218	3'(2'),5'-bisphosphate nucleotidase
HW02_RS10595	COG0494	nUDIX hydrolase
HW02_RS10600	COG1011	Hydrolase
HW02_RS10605	COG1652	LysM domain
HW02_RS10615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW02_RS10635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW02_RS10645	COG0824	Thioesterase
HW02_RS10650	COG1454	alcohol dehydrogenase
HW02_RS10655	COG1960	acyl-CoA dehydrogenase activity
HW02_RS10660	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS10660	COG1024	Enoyl-CoA hydratase
HW02_RS10670	COG0778	Nitroreductase
HW02_RS10695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW02_RS10700	COG0189	ligase activity
HW02_RS10700	COG4067	protein conserved in archaea
HW02_RS10725	COG2183	response to ionizing radiation
HW02_RS10755	COG0306	phosphate transporter
HW02_RS10760	COG1392	Phosphate transport regulator
HW02_RS10765	COG3025	triphosphatase activity
HW02_RS10770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS10800	COG1178	ABC-type Fe3 transport system permease component
HW02_RS10810	COG0583	DNA-binding transcription factor activity
HW02_RS10825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW02_RS10835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW02_RS10840	COG0006	proline dipeptidase activity
HW02_RS10865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW02_RS10875	COG0842	Transport permease protein
HW02_RS10880	COG0842	Transport permease protein
HW02_RS10880	COG1129	ABC transporter
HW02_RS10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS10900	COG2271	Major facilitator Superfamily
HW02_RS10915	COG2755	lipolytic protein G-D-S-L family
HW02_RS10915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW02_RS10930	COG0248	Ppx GppA phosphatase
HW02_RS10945	COG0586	Pfam SNARE associated Golgi protein
HW02_RS10950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HW02_RS10955	COG2050	protein possibly involved in aromatic compounds catabolism
HW02_RS10965	COG0672	)-iron permease
HW02_RS10970	COG1280	lysine exporter protein (LysE YggA)
HW02_RS10975	COG0861	Integral membrane protein TerC family
HW02_RS10985	COG0488	(ABC) transporter
HW02_RS11040	COG3275	phosphorelay sensor kinase activity
HW02_RS11070	COG0598	Magnesium transport protein CorA
HW02_RS11100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW02_RS11160	COG0432	Pfam Uncharacterised protein family UPF0047
HW02_RS11165	COG0004	ammonium transporteR
HW02_RS11170	COG0347	Belongs to the P(II) protein family
HW02_RS11180	COG0606	chelatase, subunit chli
HW02_RS11185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW02_RS11195	COG0583	DNA-binding transcription factor activity
HW02_RS11210	COG0210	DNA helicase
HW02_RS11215	COG0028	Belongs to the TPP enzyme family
HW02_RS11225	COG0427	acetyl-CoA hydrolase
HW02_RS11235	COG1396	sequence-specific DNA binding
HW02_RS11235	COG1917	Cupin 2, conserved barrel domain protein
HW02_RS11245	COG0251	oxidation-reduction process
HW02_RS11275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS11280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW02_RS11285	COG2814	Major facilitator Superfamily
HW02_RS11290	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS11295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW02_RS11315	COG0747	negative chemotaxis
HW02_RS11330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW02_RS11370	COG3245	cytochrome
HW02_RS11390	COG0708	Exodeoxyribonuclease III
HW02_RS11405	COG1561	YicC-like family, N-terminal region
HW02_RS11420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW02_RS11440	COG2207	Transcriptional regulator
HW02_RS11440	COG4753	response regulator
HW02_RS11450	COG0583	DNA-binding transcription factor activity
HW02_RS11455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW02_RS11490	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HW02_RS11495	COG0247	lactate metabolic process
HW02_RS11500	COG0277	FAD linked oxidase domain protein
HW02_RS11505	COG0277	FAD linked oxidase domain protein
HW02_RS11510	COG2186	Transcriptional regulator
HW02_RS11540	COG1253	flavin adenine dinucleotide binding
HW02_RS11545	COG0739	heme binding
HW02_RS11565	COG0573	inorganic phosphate transmembrane transporter activity
HW02_RS11630	COG4584	PFAM Integrase catalytic
HW02_RS11635	COG1484	DNA-dependent DNA replication
HW02_RS11640	COG2963	transposase activity
HW02_RS11645	COG2801	Transposase and inactivated derivatives
HW02_RS11650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS11690	COG3474	cytochrome
HW02_RS11800	COG2837	iron assimilation
HW02_RS11810	COG1024	Enoyl-CoA hydratase
HW02_RS11810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS11820	COG1051	belongs to the nudix hydrolase family
HW02_RS11855	COG0477	Major facilitator Superfamily
HW02_RS11860	COG1607	acyl-coa hydrolase
HW02_RS11880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW02_RS11885	COG4175	Glycine betaine
HW02_RS11890	COG4176	ABC-type proline glycine betaine transport system permease component
HW02_RS11900	COG1760	l-serine dehydratase
HW02_RS11915	COG0583	DNA-binding transcription factor activity
HW02_RS11925	COG0657	acetylesterase activity
HW02_RS11940	COG3246	L-lysine catabolic process to acetate
HW02_RS11995	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS11995	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS12000	COG2181	nitrate reductase activity
HW02_RS12000	COG0247	lactate metabolic process
HW02_RS12020	COG3655	Transcriptional regulator
HW02_RS12060	COG1017	nitric oxide dioxygenase activity
HW02_RS12060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW02_RS12145	COG0583	DNA-binding transcription factor activity
HW02_RS12155	COG2391	methyltransferase activity
HW02_RS12180	COG5016	pyruvate
HW02_RS12180	COG0511	ligase activity, forming carbon-carbon bonds
HW02_RS12185	COG0439	Biotin carboxylase
HW02_RS12190	COG0583	DNA-binding transcription factor activity
HW02_RS12205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW02_RS12210	COG0826	peptidase U32
HW02_RS12230	COG0210	DNA helicase
HW02_RS12240	COG0427	acetyl-CoA hydrolase
HW02_RS12255	COG0438	transferase activity, transferring glycosyl groups
HW02_RS12300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW02_RS12305	COG2755	lipolytic protein G-D-S-L family
HW02_RS12305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW02_RS12345	COG0679	Auxin Efflux Carrier
HW02_RS12355	COG2851	Citrate transporter
HW02_RS12360	COG0861	Integral membrane protein TerC family
HW02_RS12365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW02_RS12370	COG1690	Belongs to the RtcB family
HW02_RS12405	COG0700	Nucleoside recognition
HW02_RS12410	COG1301	dicarboxylic acid transport
HW02_RS12435	COG5002	protein histidine kinase activity
HW02_RS12440	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW02_RS12445	COG2095	MarC family integral membrane protein
HW02_RS12470	COG3245	cytochrome
HW02_RS12505	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HW02_RS12510	COG0735	belongs to the Fur family
HW02_RS12520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW02_RS12535	COG2011	ABC-type metal ion transport system permease component
HW02_RS12565	COG0531	amino acid
HW02_RS12575	COG4191	Histidine kinase
HW02_RS12610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW02_RS12610	COG4651	solute:proton antiporter activity
HW02_RS12615	COG1607	acyl-coa hydrolase
HW02_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS12630	COG0174	glutamine synthetase
HW02_RS12635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW02_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS12665	COG4651	solute:proton antiporter activity
HW02_RS12665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW02_RS12670	COG0477	Major facilitator Superfamily
HW02_RS12680	COG0523	cobalamin synthesis protein
HW02_RS12725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW02_RS12745	COG2358	TRAP transporter, solute receptor (TAXI family
HW02_RS12750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW02_RS12770	COG1349	DNA-binding transcription factor activity
HW02_RS12830	COG1475	DNA binding
HW02_RS12835	COG1192	Involved in chromosome partitioning
HW02_RS12895	COG2801	Transposase and inactivated derivatives
HW02_RS12900	COG2963	transposase activity
HW02_RS12905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS12935	COG2010	Cytochrome c
HW02_RS12950	COG2818	Glycosylase
HW02_RS12965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HW02_RS12980	COG0569	domain protein
HW02_RS13000	COG1652	LysM domain
HW02_RS13005	COG0758	DNA mediated transformation
HW02_RS13035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS13055	COG3119	arylsulfatase activity
HW02_RS13060	COG0583	DNA-binding transcription factor activity
HW02_RS13095	COG3360	Dodecin
HW02_RS13140	COG3174	membrane
HW02_RS13185	COG0367	asparagine synthase
HW02_RS13205	COG0583	DNA-binding transcription factor activity
HW02_RS13220	COG1764	response to oxidative stress
HW02_RS13255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW02_RS13260	COG0339	signal peptide processing
HW02_RS13265	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HW02_RS13280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HW02_RS13295	COG0515	serine threonine protein kinase
HW02_RS13295	COG2815	serine threonine protein kinase
HW02_RS13300	COG0631	protein serine/threonine phosphatase activity
HW02_RS13315	COG1360	Flagellar Motor Protein
HW02_RS13440	COG0659	secondary active sulfate transmembrane transporter activity
HW02_RS13450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW02_RS13455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW02_RS13460	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HW02_RS13500	COG2153	protein acetylation
HW02_RS13540	COG0583	DNA-binding transcription factor activity
HW02_RS13565	COG2824	Alkylphosphonate utilization operon protein PhnA
HW02_RS13595	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS13605	COG3845	ABC transporter
HW02_RS13610	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW02_RS13615	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW02_RS13685	COG0583	DNA-binding transcription factor activity
HW02_RS13690	COG3485	protocatechuate 3,4-dioxygenase
HW02_RS13695	COG3485	protocatechuate 3,4-dioxygenase
HW02_RS13700	COG1414	Transcriptional regulator
HW02_RS13715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS13720	COG0583	DNA-binding transcription factor activity
HW02_RS13755	COG2233	PERMEase
HW02_RS13760	COG1309	transcriptional regulator
HW02_RS13795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HW02_RS13810	COG0835	chemotaxis
HW02_RS13815	COG0643	Histidine kinase
HW02_RS13815	COG2198	Histidine kinase
HW02_RS13820	COG0745	RESPONSE REGULATOR receiver
HW02_RS13830	COG0583	DNA-binding transcription factor activity
HW02_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS13845	COG1116	anion transmembrane transporter activity
HW02_RS13850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS13855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS13895	COG2175	clavaminate synthase activity
HW02_RS13950	COG1177	transmembrane transport
HW02_RS13955	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS13965	COG0583	DNA-binding transcription factor activity
HW02_RS14000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW02_RS14025	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS14030	COG1113	amino acid transport
HW02_RS14045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS14050	COG0235	Class ii aldolase
HW02_RS14055	COG1396	sequence-specific DNA binding
HW02_RS14060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW02_RS14065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW02_RS14075	COG0477	Major facilitator Superfamily
HW02_RS14085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS14090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS14095	COG0583	DNA-binding transcription factor activity
HW02_RS14115	COG0673	inositol 2-dehydrogenase activity
HW02_RS14135	COG2271	Major facilitator Superfamily
HW02_RS14145	COG1309	transcriptional regulator
HW02_RS14150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW02_RS14160	COG0477	Major facilitator Superfamily
HW02_RS14180	COG2239	Acts as a magnesium transporter
HW02_RS14295	COG0745	RESPONSE REGULATOR receiver
HW02_RS14305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS14320	COG0583	DNA-binding transcription factor activity
HW02_RS14325	COG2807	transmembrane transport
HW02_RS14345	COG0501	Belongs to the peptidase M48B family
HW02_RS14365	COG4208	sulfate ABC transporter
HW02_RS14375	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HW02_RS14410	COG2199	diguanylate cyclase activity
HW02_RS14435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW02_RS14440	COG0174	glutamine synthetase
HW02_RS14445	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW02_RS14450	COG0174	glutamine synthetase
HW02_RS14470	COG3842	ATPase activity
HW02_RS14475	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS14480	COG1177	transmembrane transport
HW02_RS14530	COG0765	amino acid transport
HW02_RS14545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW02_RS14550	COG0277	FAD linked oxidase domain protein
HW02_RS14555	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW02_RS14565	COG3111	PFAM Bacterial OB fold (BOF) protein
HW02_RS14575	COG0531	amino acid
HW02_RS14580	COG2182	Extracellular solute-binding protein
HW02_RS14585	COG1177	transmembrane transport
HW02_RS14595	COG3842	ATPase activity
HW02_RS14600	COG3204	pilus organization
HW02_RS14605	COG2234	aminopeptidase activity
HW02_RS14625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW02_RS14635	COG0702	epimerase
HW02_RS14675	COG0730	response to heat
HW02_RS14710	COG0584	glycerophosphoryl diester phosphodiesterase
HW02_RS14730	COG0622	Phosphoesterase
HW02_RS14735	COG2233	PERMEase
HW02_RS14750	COG0693	protein deglycase activity
HW02_RS14785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW02_RS14795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HW02_RS14820	COG0429	hydrolase of the alpha beta-hydrolase fold
HW02_RS14830	COG0742	ribosomal rna small subunit methyltransferase
HW02_RS14835	COG0612	Peptidase, M16
HW02_RS14840	COG0612	Peptidase, M16
HW02_RS14845	COG0552	protein localization to endoplasmic reticulum
HW02_RS14850	COG2884	Cell division ATP-binding protein ftsE
HW02_RS14855	COG2177	Part of the ABC transporter FtsEX involved in
HW02_RS14875	COG2363	Small membrane protein
HW02_RS14910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW02_RS14925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS14925	COG2813	Specifically methylates the guanine in position
HW02_RS14935	COG1160	GTP binding
HW02_RS14940	COG1872	DUF167
HW02_RS14985	COG0626	cystathionine gamma-synthase activity
HW02_RS15050	COG2198	Histidine kinase
HW02_RS15050	COG0784	Response regulator, receiver
HW02_RS15050	COG0643	Histidine kinase
HW02_RS15080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW02_RS15095	COG3038	cytochrome b561
HW02_RS15125	COG0513	Belongs to the DEAD box helicase family
HW02_RS15135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW02_RS15140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW02_RS15165	COG1309	transcriptional regulator
HW02_RS15170	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS15175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW02_RS15200	COG1953	Uracil, thiamine, allantoin
HW02_RS15215	COG1960	acyl-CoA dehydrogenase activity
HW02_RS15220	COG0583	DNA-binding transcription factor activity
HW02_RS15230	COG0306	phosphate transporter
HW02_RS15240	COG0330	HflC and HflK could
HW02_RS15250	COG1289	transmembrane transporter activity
HW02_RS15255	COG0513	Belongs to the DEAD box helicase family
HW02_RS15265	COG4067	protein conserved in archaea
HW02_RS15265	COG0189	ligase activity
HW02_RS15275	COG0477	Major facilitator Superfamily
HW02_RS15280	COG0542	response to heat
HW02_RS15290	COG0204	Acyl-transferase
HW02_RS15300	COG0745	RESPONSE REGULATOR receiver
HW02_RS15305	COG2205	protein histidine kinase activity
HW02_RS15310	COG4452	Inner membrane protein CreD
HW02_RS15340	COG4774	siderophore transport
HW02_RS15345	COG3712	iron ion homeostasis
HW02_RS15350	COG1595	DNA-templated transcription, initiation
HW02_RS15355	COG0625	glutathione transferase activity
HW02_RS15365	COG1309	transcriptional regulator
HW02_RS15370	COG1953	Uracil, thiamine, allantoin
HW02_RS15390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS15425	COG2005	Transcriptional regulator
HW02_RS15425	COG3585	molybdate ion transport
HW02_RS15430	COG5544	Lipoprotein
HW02_RS15435	COG1040	competence protein
HW02_RS15455	COG0511	ligase activity, forming carbon-carbon bonds
HW02_RS15470	COG1984	allophanate hydrolase subunit 2
HW02_RS15485	COG3121	Chaperone
HW02_RS15500	COG1073	alpha beta
HW02_RS15500	COG2226	methyltransferase
HW02_RS15520	COG1960	acyl-CoA dehydrogenase activity
HW02_RS15525	COG1960	acyl-CoA dehydrogenase activity
HW02_RS15530	COG1960	acyl-CoA dehydrogenase activity
HW02_RS15540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW02_RS15540	COG1648	precorrin-2 dehydrogenase activity
HW02_RS15630	COG0583	DNA-binding transcription factor activity
HW02_RS15635	COG2258	MOSC domain
HW02_RS15645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW02_RS15665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS15675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW02_RS15730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW02_RS15735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW02_RS15745	COG3622	Belongs to the hyi family
HW02_RS15750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW02_RS15790	COG2081	HI0933 family
HW02_RS15795	COG1451	nucleotide metabolic process
HW02_RS15800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW02_RS15805	COG3152	Membrane
HW02_RS15810	COG4977	sequence-specific DNA binding
HW02_RS15810	COG1917	Cupin 2, conserved barrel domain protein
HW02_RS15815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS15875	COG3344	reverse transcriptase
HW02_RS15915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW02_RS15935	COG2719	SpoVR family
HW02_RS15945	COG2766	serine protein kinase
HW02_RS15995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HW02_RS16010	COG2197	response regulator
HW02_RS16020	COG3842	ATPase activity
HW02_RS16030	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS16040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW02_RS16065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW02_RS16150	COG3179	chitinase
HW02_RS16185	COG1765	OsmC-like protein
HW02_RS16200	COG0537	adenosine 5'-monophosphoramidase activity
HW02_RS16210	COG0300	oxidoreductase activity
HW02_RS16225	COG1981	membrane
HW02_RS16255	COG0739	heme binding
HW02_RS16420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW02_RS16545	COG2814	Major facilitator Superfamily
HW02_RS16570	COG1021	2,3-dihydroxybenzoate-AMP ligase
HW02_RS16580	COG3433	isochorismatase activity
HW02_RS16580	COG2226	methyltransferase
HW02_RS16580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS16585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS16585	COG2226	methyltransferase
HW02_RS16585	COG3433	isochorismatase activity
HW02_RS16595	COG2375	cellular response to nickel ion
HW02_RS16595	COG1132	(ABC) transporter
HW02_RS16675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS16680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS16690	COG2706	6-phosphogluconolactonase activity
HW02_RS16710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS16715	COG1960	acyl-CoA dehydrogenase activity
HW02_RS16725	COG4191	Histidine kinase
HW02_RS16730	COG4566	intracellular signal transduction
HW02_RS16735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS16740	COG0765	amino acid transport
HW02_RS16745	COG0765	amino acid transport
HW02_RS16765	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS16770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS16775	COG2271	Major facilitator Superfamily
HW02_RS16820	COG2226	methyltransferase
HW02_RS16830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS16845	COG0251	oxidation-reduction process
HW02_RS16855	COG0693	protein deglycase activity
HW02_RS16860	COG0492	ferredoxin-NADP+ reductase activity
HW02_RS16865	COG1959	2 iron, 2 sulfur cluster binding
HW02_RS16895	COG0154	amidase activity
HW02_RS16900	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS16905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS16910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS16915	COG4592	Periplasmic binding protein
HW02_RS16920	COG1120	ATPase activity
HW02_RS16930	COG4774	siderophore transport
HW02_RS16930	COG1629	transport
HW02_RS16935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS16940	COG4991	sh3 domain protein
HW02_RS16945	COG1063	alcohol dehydrogenase
HW02_RS16955	COG0022	dehydrogenase e1 component
HW02_RS16960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW02_RS16965	COG3199	ATP-NAD kinase
HW02_RS16975	COG3284	Transcriptional regulator
HW02_RS17000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS17160	COG3646	Phage regulatory protein
HW02_RS17170	COG3179	chitinase
HW02_RS17210	COG0740	serine-type endopeptidase activity
HW02_RS17320	COG2814	Major facilitator Superfamily
HW02_RS17325	COG1846	Transcriptional regulator
HW02_RS17335	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS17340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS17350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS17365	COG3971	2-oxopent-4-enoate hydratase activity
HW02_RS17370	COG2271	Major facilitator Superfamily
HW02_RS17380	COG3384	dioxygenase
HW02_RS17385	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS17425	COG1611	Belongs to the LOG family
HW02_RS17470	COG0583	DNA-binding transcription factor activity
HW02_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS17495	COG1063	alcohol dehydrogenase
HW02_RS17500	COG2271	Major facilitator Superfamily
HW02_RS17535	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS17540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW02_RS17555	COG3121	Chaperone
HW02_RS17580	COG2197	response regulator
HW02_RS17620	COG0531	amino acid
HW02_RS17640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW02_RS17650	COG3047	cAMP biosynthetic process
HW02_RS17680	COG3118	belongs to the thioredoxin family
HW02_RS17685	COG2264	protein methyltransferase activity
HW02_RS17700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW02_RS17700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW02_RS17725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HW02_RS17730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW02_RS17740	COG3577	Aspartyl protease
HW02_RS17765	COG0142	geranyltranstransferase activity
HW02_RS17775	COG4948	Mandelate Racemase Muconate Lactonizing
HW02_RS17795	COG1131	(ABC) transporter
HW02_RS17820	COG0745	RESPONSE REGULATOR receiver
HW02_RS17830	COG3228	Belongs to the MtfA family
HW02_RS17835	COG0586	Pfam SNARE associated Golgi protein
HW02_RS17850	COG0456	acetyltransferase
HW02_RS17860	COG4303	Ethanolamine ammonia lyase large subunit
HW02_RS17865	COG0531	amino acid
HW02_RS17875	COG3284	Transcriptional regulator
HW02_RS17880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW02_RS17895	COG0702	epimerase
HW02_RS17915	COG1346	cytolysis
HW02_RS17925	COG0586	Pfam SNARE associated Golgi protein
HW02_RS17965	COG0768	penicillin binding
HW02_RS17970	COG0772	Belongs to the SEDS family
HW02_RS17975	COG2951	lytic endotransglycosylase activity
HW02_RS17985	COG1686	Belongs to the peptidase S11 family
HW02_RS18015	COG2951	lytic endotransglycosylase activity
HW02_RS18050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HW02_RS18060	COG4535	Mg2 and Co2 transporter CorC
HW02_RS18070	COG1702	phosphate starvation-inducible protein PhoH
HW02_RS18100	COG0351	phosphomethylpyrimidine kinase
HW02_RS18105	COG2205	protein histidine kinase activity
HW02_RS18105	COG2198	Histidine kinase
HW02_RS18105	COG0784	Response regulator, receiver
HW02_RS18115	COG1960	acyl-CoA dehydrogenase activity
HW02_RS18125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW02_RS18165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW02_RS18175	COG1643	Atp-dependent helicase
HW02_RS18220	COG3416	Protein conserved in bacteria
HW02_RS18230	COG0513	Belongs to the DEAD box helicase family
HW02_RS18240	COG2197	response regulator
HW02_RS18245	COG2199	diguanylate cyclase activity
HW02_RS18245	COG2200	EAL domain
HW02_RS18245	COG2202	Pas domain
HW02_RS18250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS18250	COG2205	protein histidine kinase activity
HW02_RS18270	COG1946	Acyl-CoA thioesterase
HW02_RS18290	COG4521	taurine ABC transporter
HW02_RS18300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS18305	COG2175	clavaminate synthase activity
HW02_RS18310	COG1297	OPT oligopeptide transporter protein
HW02_RS18315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW02_RS18330	COG1271	oxidase subunit
HW02_RS18335	COG1294	oxidase, subunit
HW02_RS18345	COG2207	Transcriptional regulator
HW02_RS18355	COG0183	Belongs to the thiolase family
HW02_RS18360	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS18385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW02_RS18395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HW02_RS18405	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW02_RS18410	COG0303	'Molybdopterin
HW02_RS18415	COG0826	peptidase U32
HW02_RS18420	COG0826	peptidase U32
HW02_RS18425	COG3154	lipid carrier protein
HW02_RS18475	COG4772	TonB-dependent receptor
HW02_RS18480	COG3712	iron ion homeostasis
HW02_RS18485	COG1595	DNA-templated transcription, initiation
HW02_RS18495	COG0697	spore germination
HW02_RS18505	COG0583	DNA-binding transcription factor activity
HW02_RS18525	COG1566	PFAM secretion protein HlyD family protein
HW02_RS18575	COG0300	oxidoreductase activity
HW02_RS18580	COG2226	methyltransferase
HW02_RS18595	COG2197	response regulator
HW02_RS18600	COG3850	Histidine kinase
HW02_RS18610	COG2223	nitrite transmembrane transporter activity
HW02_RS18615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW02_RS18620	COG1140	nitrate reductase beta subunit
HW02_RS18625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW02_RS18630	COG2181	nitrate reductase activity
HW02_RS18635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS18645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS18670	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS18680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS18745	COG0583	DNA-binding transcription factor activity
HW02_RS18770	COG0490	domain, Protein
HW02_RS18770	COG0471	metal ion transport
HW02_RS18775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HW02_RS18780	COG4120	Belongs to the binding-protein-dependent transport system permease family
HW02_RS18825	COG0795	lipopolysaccharide-transporting ATPase activity
HW02_RS18830	COG0795	lipopolysaccharide-transporting ATPase activity
HW02_RS18840	COG2200	EAL domain
HW02_RS18845	COG2801	Transposase and inactivated derivatives
HW02_RS18875	COG1862	Preprotein translocase
HW02_RS18890	COG3134	Outer membrane lipoprotein
HW02_RS18905	COG1045	serine acetyltransferase
HW02_RS18995	COG0436	Aminotransferase
HW02_RS19010	COG0667	Aldo Keto reductase
HW02_RS19050	COG0739	heme binding
HW02_RS19060	COG2847	Copper chaperone PCu(A)C
HW02_RS19070	COG1335	isochorismatase
HW02_RS19085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW02_RS19095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW02_RS19100	COG0583	DNA-binding transcription factor activity
HW02_RS19160	COG0738	Major facilitator superfamily
HW02_RS19170	COG2130	NADP-dependent
HW02_RS19175	COG2132	Multicopper oxidase
HW02_RS19180	COG0590	tRNA wobble adenosine to inosine editing
HW02_RS19215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW02_RS19215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW02_RS19220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW02_RS19225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW02_RS19230	COG2188	Transcriptional regulator
HW02_RS19270	COG0477	Major facilitator Superfamily
HW02_RS19275	COG4536	flavin adenine dinucleotide binding
HW02_RS19285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW02_RS19310	COG1607	acyl-coa hydrolase
HW02_RS19330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW02_RS19355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW02_RS19395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW02_RS19405	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS19450	COG2197	response regulator
HW02_RS19455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW02_RS19475	COG0477	Major facilitator Superfamily
HW02_RS19510	COG5001	Diguanylate cyclase
HW02_RS19510	COG2203	Gaf domain
HW02_RS19510	COG3706	GGDEF domain
HW02_RS19510	COG4251	negative regulation of phosphorylation
HW02_RS19515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW02_RS19545	COG3064	Membrane
HW02_RS19545	COG1073	alpha beta
HW02_RS19545	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HW02_RS19560	COG2885	chlorophyll binding
HW02_RS19575	COG0789	Transcriptional regulator
HW02_RS19595	COG1214	PFAM Peptidase M22, glycoprotease
HW02_RS19605	COG1801	Protein of unknown function DUF72
HW02_RS19610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HW02_RS19635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS19680	COG2166	iron-sulfur cluster assembly
HW02_RS19695	COG1280	lysine exporter protein (LysE YggA)
HW02_RS19700	COG1393	Belongs to the ArsC family
HW02_RS19720	COG0025	NhaP-type Na H and K H
HW02_RS19725	COG0436	Aminotransferase
HW02_RS19735	COG0024	Methionine aminopeptidase
HW02_RS19780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW02_RS19815	COG1115	amino acid carrier protein
HW02_RS19865	COG2391	methyltransferase activity
HW02_RS19870	COG0583	DNA-binding transcription factor activity
HW02_RS19875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HW02_RS19880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HW02_RS19930	COG1546	Belongs to the CinA family
HW02_RS19950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW02_RS19955	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HW02_RS19960	COG3530	Putative quorum-sensing-regulated virulence factor
HW02_RS19975	COG1177	transmembrane transport
HW02_RS19980	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS19990	COG3148	PFAM DTW domain containing protein
HW02_RS20035	COG0531	amino acid
HW02_RS20040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW02_RS20040	COG2169	Transcriptional regulator
HW02_RS20045	COG0477	Major facilitator Superfamily
HW02_RS20050	COG0583	DNA-binding transcription factor activity
HW02_RS20055	COG1960	acyl-CoA dehydrogenase activity
HW02_RS20060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW02_RS20065	COG1024	Enoyl-CoA hydratase
HW02_RS20070	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS20075	COG0183	Belongs to the thiolase family
HW02_RS20085	COG0583	DNA-binding transcription factor activity
HW02_RS20120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW02_RS20160	COG2814	Major facilitator Superfamily
HW02_RS20200	COG0583	DNA-binding transcription factor activity
HW02_RS20230	COG0084	hydrolase, TatD family'
HW02_RS20235	COG1609	Transcriptional regulator
HW02_RS20245	COG1105	Belongs to the carbohydrate kinase PfkB family
HW02_RS20250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HW02_RS20250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW02_RS20250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW02_RS20360	COG3842	ATPase activity
HW02_RS20380	COG0243	molybdopterin cofactor binding
HW02_RS20385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HW02_RS20390	COG2223	nitrite transmembrane transporter activity
HW02_RS20405	COG0450	alkyl hydroperoxide reductase
HW02_RS20435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS20460	COG5566	PFAM Mor transcription activator
HW02_RS20520	COG0488	(ABC) transporter
HW02_RS20585	COG0640	Transcriptional regulator
HW02_RS20595	COG4373	Mu-like prophage FluMu protein gp28
HW02_RS20600	COG4383	Mu-like prophage protein gp29
HW02_RS20625	COG4397	Mu-like prophage major head subunit gpT
HW02_RS20725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW02_RS20730	COG2264	protein methyltransferase activity
HW02_RS20740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW02_RS20795	COG0489	protein tyrosine kinase activity
HW02_RS20840	COG0791	NLP P60 protein
HW02_RS20855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW02_RS20860	COG0668	transmembrane transport
HW02_RS20865	COG0477	Major facilitator Superfamily
HW02_RS20870	COG0513	Belongs to the DEAD box helicase family
HW02_RS20890	COG0784	Response regulator, receiver
HW02_RS20890	COG5002	protein histidine kinase activity
HW02_RS20890	COG2205	protein histidine kinase activity
HW02_RS20895	COG1363	Peptidase, m42
HW02_RS20900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW02_RS20900	COG0189	ligase activity
HW02_RS20905	COG0367	asparagine synthase
HW02_RS20930	COG0183	Belongs to the thiolase family
HW02_RS20950	COG0450	alkyl hydroperoxide reductase
HW02_RS20955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS20960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS20970	COG0431	NADPH-dependent FMN reductase
HW02_RS20975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS20985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS21010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW02_RS21035	COG0583	DNA-binding transcription factor activity
HW02_RS21040	COG1380	Effector of murein hydrolase LrgA
HW02_RS21045	COG1346	cytolysis
HW02_RS21065	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS21070	COG1024	Enoyl-CoA hydratase
HW02_RS21080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW02_RS21125	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW02_RS21165	COG1629	transport
HW02_RS21220	COG0583	DNA-binding transcription factor activity
HW02_RS21295	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW02_RS21300	COG3639	organic phosphonate transmembrane transporter activity
HW02_RS21305	COG2188	Transcriptional regulator
HW02_RS21310	COG3624	Phosphonate C-P lyase system protein PhnG
HW02_RS21320	COG3626	phosphonate metabolism
HW02_RS21325	COG3627	carbon phosphorus lyase activity
HW02_RS21330	COG4107	phosphonate C-P lyase system protein PhnK
HW02_RS21335	COG4778	phosphonate C-P lyase system protein PhnL
HW02_RS21340	COG3454	Phosphonate metabolism
HW02_RS21350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW02_RS21465	COG0697	spore germination
HW02_RS21490	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HW02_RS21510	COG0784	Response regulator, receiver
HW02_RS21510	COG0835	chemotaxis
HW02_RS21525	COG0745	RESPONSE REGULATOR receiver
HW02_RS21535	COG0514	ATP-dependent DNA helicase (RecQ)
HW02_RS21540	COG5001	Diguanylate cyclase
HW02_RS21540	COG2203	Gaf domain
HW02_RS21540	COG4251	negative regulation of phosphorylation
HW02_RS21540	COG3706	GGDEF domain
HW02_RS21560	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW02_RS21600	COG2124	cytochrome p450
HW02_RS21605	COG4221	oxidoreductase activity
HW02_RS21620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS21650	COG0583	DNA-binding transcription factor activity
HW02_RS21680	COG3639	organic phosphonate transmembrane transporter activity
HW02_RS21690	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW02_RS21695	COG2084	Dehydrogenase
HW02_RS21710	COG0589	response to stress
HW02_RS21750	COG2814	Major facilitator Superfamily
HW02_RS21755	COG2030	dehydratase
HW02_RS21760	COG2267	carboxylic ester hydrolase activity
HW02_RS21765	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS21770	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS21780	COG1643	Atp-dependent helicase
HW02_RS21790	COG0537	adenosine 5'-monophosphoramidase activity
HW02_RS21840	COG1595	DNA-templated transcription, initiation
HW02_RS21910	COG1201	RNA secondary structure unwinding
HW02_RS21915	COG0784	Response regulator, receiver
HW02_RS21915	COG2205	protein histidine kinase activity
HW02_RS21930	COG4772	TonB-dependent receptor
HW02_RS21945	COG2076	Multidrug Resistance protein
HW02_RS21950	COG0385	Bile acid
HW02_RS22000	COG2200	EAL domain
HW02_RS22010	COG3321	synthase
HW02_RS22010	COG0604	alcohol dehydrogenase
HW02_RS22015	COG0560	Phosphoserine phosphatase
HW02_RS22030	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS22060	COG0564	pseudouridine synthase activity
HW02_RS22070	COG2894	cell division
HW02_RS22080	COG1560	Kdo2-lipid A biosynthetic process
HW02_RS22095	COG2853	Lipoprotein
HW02_RS22115	COG3162	membrane
HW02_RS22120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW02_RS22150	COG1132	(ABC) transporter
HW02_RS22160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS22185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW02_RS22200	COG0438	transferase activity, transferring glycosyl groups
HW02_RS22200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW02_RS22230	COG1127	ABC transporter
HW02_RS22235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW02_RS22240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW02_RS22245	COG0727	PFAM Uncharacterised protein family (UPF0153)
HW02_RS22250	COG0778	Nitroreductase
HW02_RS22270	COG0745	RESPONSE REGULATOR receiver
HW02_RS22280	COG2350	Protein conserved in bacteria
HW02_RS22290	COG0613	PHP domain protein
HW02_RS22295	COG0009	L-threonylcarbamoyladenylate synthase
HW02_RS22305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW02_RS22350	COG1175	transmembrane transport
HW02_RS22355	COG0395	ABC-type sugar transport system, permease component
HW02_RS22360	COG3842	ATPase activity
HW02_RS22370	COG0676	glucose-6-phosphate 1-epimerase activity
HW02_RS22415	COG0786	glutamate:sodium symporter activity
HW02_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS22445	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS22475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW02_RS22525	COG0367	asparagine synthase
HW02_RS22540	COG0438	transferase activity, transferring glycosyl groups
HW02_RS22545	COG0438	transferase activity, transferring glycosyl groups
HW02_RS22555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW02_RS22595	COG0583	DNA-binding transcription factor activity
HW02_RS22630	COG0596	Alpha beta hydrolase
HW02_RS22635	COG0800	Aldolase
HW02_RS22650	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS22670	COG0583	DNA-binding transcription factor activity
HW02_RS22675	COG0251	oxidation-reduction process
HW02_RS22695	COG2226	methyltransferase
HW02_RS22735	COG0285	dihydrofolate synthase activity
HW02_RS22740	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW02_RS22745	COG1286	toxin biosynthetic process
HW02_RS22845	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS22845	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS22870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW02_RS22880	COG3139	Protein of unknown function (DUF1315)
HW02_RS22890	COG0308	aminopeptidase N
HW02_RS22920	COG0745	RESPONSE REGULATOR receiver
HW02_RS22955	COG0714	Associated with various cellular activities
HW02_RS22975	COG1335	isochorismatase
HW02_RS22985	COG2342	PFAM TM1410 hypothetical-related protein
HW02_RS23010	COG0297	glycogen (starch) synthase activity
HW02_RS23060	COG3130	regulation of translation
HW02_RS23070	COG2027	D-alanyl-D-alanine carboxypeptidase
HW02_RS23075	COG3171	Protein conserved in bacteria
HW02_RS23080	COG2197	response regulator
HW02_RS23135	COG4644	lycopene metabolic process
HW02_RS23140	COG2205	protein histidine kinase activity
HW02_RS23140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS23165	COG0004	ammonium transporteR
HW02_RS23175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS23185	COG0625	glutathione transferase activity
HW02_RS23190	COG1309	transcriptional regulator
HW02_RS23220	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW02_RS23240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW02_RS23245	COG1070	Carbohydrate kinase
HW02_RS23265	COG0741	lytic transglycosylase activity
HW02_RS23270	COG0488	(ABC) transporter
HW02_RS23280	COG0589	response to stress
HW02_RS23355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW02_RS23365	COG1113	amino acid transport
HW02_RS23400	COG1477	protein flavinylation
HW02_RS23415	COG0584	glycerophosphoryl diester phosphodiesterase
HW02_RS23430	COG4591	ABC-type transport system involved in lipoprotein release permease component
HW02_RS23450	COG2333	competence protein COMEC
HW02_RS23450	COG0658	competence protein
HW02_RS23455	COG0811	peptide transport
HW02_RS23460	COG0848	biopolymer transport protein
HW02_RS23480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW02_RS23490	COG1530	ribonuclease E activity
HW02_RS23505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW02_RS23505	COG0616	signal peptide processing
HW02_RS23515	COG1399	metal-binding, possibly nucleic acid-binding protein
HW02_RS23545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW02_RS23555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW02_RS23575	COG0084	hydrolase, TatD family'
HW02_RS23660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW02_RS23675	COG0183	Belongs to the thiolase family
HW02_RS23685	COG2233	PERMEase
HW02_RS23715	COG2814	Major facilitator Superfamily
HW02_RS23720	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS23725	COG1309	transcriptional regulator
HW02_RS23760	COG4160	amino acid transport
HW02_RS23765	COG4215	(ABC) transporter
HW02_RS23770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS23775	COG1473	amidohydrolase
HW02_RS23780	COG0583	DNA-binding transcription factor activity
HW02_RS23785	COG0840	transmembrane signaling receptor activity
HW02_RS23815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS23825	COG1120	ATPase activity
HW02_RS23855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS23885	COG2885	chlorophyll binding
HW02_RS23885	COG3047	cAMP biosynthetic process
HW02_RS23890	COG2197	response regulator
HW02_RS23900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS23905	COG1595	DNA-templated transcription, initiation
HW02_RS23920	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS23935	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW02_RS23940	COG1960	acyl-CoA dehydrogenase activity
HW02_RS23945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW02_RS23960	COG1309	transcriptional regulator
HW02_RS23990	COG0583	DNA-binding transcription factor activity
HW02_RS24000	COG0583	DNA-binding transcription factor activity
HW02_RS24010	COG0714	Associated with various cellular activities
HW02_RS24055	COG0084	hydrolase, TatD family'
HW02_RS24060	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW02_RS24065	COG2259	Doxx family
HW02_RS24080	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW02_RS24095	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HW02_RS24100	COG4181	ATPase activity
HW02_RS24140	COG1764	response to oxidative stress
HW02_RS24145	COG1846	Transcriptional regulator
HW02_RS24150	COG0583	DNA-binding transcription factor activity
HW02_RS24160	COG0583	DNA-binding transcription factor activity
HW02_RS24170	COG3214	Protein conserved in bacteria
HW02_RS24175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HW02_RS24185	COG1024	Enoyl-CoA hydratase
HW02_RS24195	COG3384	dioxygenase
HW02_RS24235	COG2866	Carboxypeptidase
HW02_RS24250	COG0436	Aminotransferase
HW02_RS24260	COG0386	Belongs to the glutathione peroxidase family
HW02_RS24265	COG1846	Transcriptional regulator
HW02_RS24270	COG5002	protein histidine kinase activity
HW02_RS24270	COG0784	Response regulator, receiver
HW02_RS24270	COG2205	protein histidine kinase activity
HW02_RS24275	COG2255	four-way junction helicase activity
HW02_RS24280	COG1956	GAF domain-containing protein
HW02_RS24285	COG0625	glutathione transferase activity
HW02_RS24310	COG0582	viral genome integration into host DNA
HW02_RS24350	COG0583	DNA-binding transcription factor activity
HW02_RS24370	COG2217	Heavy metal translocating P-type atpase
HW02_RS24390	COG2132	Multicopper oxidase
HW02_RS24395	COG0745	RESPONSE REGULATOR receiver
HW02_RS24400	COG5002	protein histidine kinase activity
HW02_RS24420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW02_RS24425	COG0789	Transcriptional regulator
HW02_RS24430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW02_RS24435	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HW02_RS24450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HW02_RS24455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW02_RS24475	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HW02_RS24480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW02_RS24490	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW02_RS24505	COG2217	Heavy metal translocating P-type atpase
HW02_RS24510	COG2326	polyphosphate kinase activity
HW02_RS24580	COG2003	Belongs to the UPF0758 family
HW02_RS24635	COG3311	Transcriptional regulator
HW02_RS24640	COG1569	PIN domain
HW02_RS24645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW02_RS24710	COG0640	Transcriptional regulator
HW02_RS24720	COG0798	PFAM Bile acid sodium symporter
HW02_RS24725	COG1393	Belongs to the ArsC family
HW02_RS24730	COG0431	NADPH-dependent FMN reductase
HW02_RS24815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW02_RS24825	COG0789	Transcriptional regulator
HW02_RS24840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS24845	COG0629	single-stranded DNA binding
HW02_RS24900	COG2200	EAL domain
HW02_RS24925	COG0625	glutathione transferase activity
HW02_RS24930	COG1131	(ABC) transporter
HW02_RS24935	COG0842	Transport permease protein
HW02_RS24980	COG2188	Transcriptional regulator
HW02_RS24990	COG2853	Lipoprotein
HW02_RS25000	COG0745	RESPONSE REGULATOR receiver
HW02_RS25020	COG1335	isochorismatase
HW02_RS25050	COG5434	Belongs to the glycosyl hydrolase 28 family
HW02_RS25080	COG3655	Transcriptional regulator
HW02_RS25120	COG2116	formate transmembrane transporter activity
HW02_RS25125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS25180	COG4644	lycopene metabolic process
HW02_RS25215	COG0789	Transcriptional regulator
HW02_RS25225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW02_RS25250	COG4372	Transposase
HW02_RS25310	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS25325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW02_RS25340	COG0589	response to stress
HW02_RS25345	COG0659	secondary active sulfate transmembrane transporter activity
HW02_RS25375	COG1061	Type III restriction enzyme res subunit
HW02_RS25400	COG0024	Methionine aminopeptidase
HW02_RS25495	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW02_RS25495	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW02_RS25505	COG0542	response to heat
HW02_RS25540	COG0789	Transcriptional regulator
HW02_RS25550	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS25550	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS25555	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW02_RS25560	COG0243	molybdopterin cofactor binding
HW02_RS25580	COG1280	lysine exporter protein (LysE YggA)
HW02_RS25595	COG0542	response to heat
HW02_RS25665	COG1607	acyl-coa hydrolase
HW02_RS25670	COG1959	2 iron, 2 sulfur cluster binding
HW02_RS25685	COG2819	hydrolase of the alpha beta superfamily
HW02_RS25730	COG0583	DNA-binding transcription factor activity
HW02_RS25740	COG4106	trans-aconitate 2-methyltransferase activity
HW02_RS25750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS25755	COG1459	type II secretion system
HW02_RS25765	COG2165	general secretion pathway protein
HW02_RS25805	COG0720	synthase
HW02_RS25810	COG3604	Transcriptional regulator
HW02_RS25870	COG0840	transmembrane signaling receptor activity
HW02_RS25875	COG2056	Na+-H+ antiporter family
HW02_RS25895	COG2226	methyltransferase
HW02_RS25990	COG2153	protein acetylation
HW02_RS25995	COG2850	peptidyl-arginine hydroxylation
HW02_RS26035	COG1278	Cold shock
HW02_RS26045	COG0542	response to heat
HW02_RS26050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW02_RS26065	COG0492	ferredoxin-NADP+ reductase activity
HW02_RS26080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW02_RS26095	COG0435	Glutathione S-transferase
HW02_RS26100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW02_RS26105	COG2920	part of a sulfur-relay system
HW02_RS26145	COG0583	DNA-binding transcription factor activity
HW02_RS26150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS26155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS26165	COG1960	acyl-CoA dehydrogenase activity
HW02_RS26170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS26180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS26185	COG3424	synthase
HW02_RS26225	COG1960	acyl-CoA dehydrogenase activity
HW02_RS26230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS26240	COG1309	transcriptional regulator
HW02_RS26250	COG1131	(ABC) transporter
HW02_RS26255	COG0842	Transport permease protein
HW02_RS26260	COG0842	Transport permease protein
HW02_RS26285	COG2197	response regulator
HW02_RS26290	COG4771	TonB-dependent receptor
HW02_RS26330	COG2205	protein histidine kinase activity
HW02_RS26330	COG0784	Response regulator, receiver
HW02_RS26330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS26330	COG2198	Histidine kinase
HW02_RS26350	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS26365	COG1522	sequence-specific DNA binding
HW02_RS26395	COG4191	Histidine kinase
HW02_RS26420	COG2203	Gaf domain
HW02_RS26420	COG3706	GGDEF domain
HW02_RS26420	COG4251	negative regulation of phosphorylation
HW02_RS26420	COG5001	Diguanylate cyclase
HW02_RS26430	COG0659	secondary active sulfate transmembrane transporter activity
HW02_RS26465	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS26475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW02_RS26485	COG0183	Belongs to the thiolase family
HW02_RS26490	COG1960	acyl-CoA dehydrogenase activity
HW02_RS26540	COG0729	surface antigen
HW02_RS26550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW02_RS26555	COG2267	carboxylic ester hydrolase activity
HW02_RS26560	COG2453	phosphatase
HW02_RS26560	COG0671	phosphoesterase, PA-phosphatase related
HW02_RS26575	COG4589	Belongs to the CDS family
HW02_RS26580	COG0667	Aldo Keto reductase
HW02_RS26590	COG1115	amino acid carrier protein
HW02_RS26600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW02_RS26620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS26625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS26630	COG1538	Outer membrane efflux protein
HW02_RS26690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW02_RS26690	COG0543	2 iron, 2 sulfur cluster binding
HW02_RS26695	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HW02_RS26700	COG4638	Rieske (2fe-2S)
HW02_RS26715	COG4948	Mandelate Racemase Muconate Lactonizing
HW02_RS26725	COG3485	protocatechuate 3,4-dioxygenase
HW02_RS26760	COG2807	transmembrane transport
HW02_RS26765	COG0590	tRNA wobble adenosine to inosine editing
HW02_RS26780	COG2318	DinB family
HW02_RS26850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS26855	COG2863	cytochrome
HW02_RS26860	COG3258	Cytochrome c
HW02_RS26865	COG0642	Histidine kinase
HW02_RS26900	COG0625	glutathione transferase activity
HW02_RS26920	COG0583	DNA-binding transcription factor activity
HW02_RS26925	COG1595	DNA-templated transcription, initiation
HW02_RS26930	COG3712	iron ion homeostasis
HW02_RS26995	COG2382	esterase
HW02_RS27015	COG0583	DNA-binding transcription factor activity
HW02_RS27035	COG1760	l-serine dehydratase
HW02_RS27040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW02_RS27075	COG2217	Heavy metal translocating P-type atpase
HW02_RS27090	COG0583	DNA-binding transcription factor activity
HW02_RS27105	COG1566	PFAM secretion protein HlyD family protein
HW02_RS27160	COG1335	isochorismatase
HW02_RS27170	COG0583	DNA-binding transcription factor activity
HW02_RS27210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW02_RS27215	COG1121	(ABC) transporter
HW02_RS27255	COG0657	acetylesterase activity
HW02_RS27260	COG4774	siderophore transport
HW02_RS27305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS27330	COG0735	belongs to the Fur family
HW02_RS27340	COG1304	FMN binding
HW02_RS27370	COG4566	intracellular signal transduction
HW02_RS27460	COG3829	transcription factor binding
HW02_RS27485	COG3829	transcription factor binding
HW02_RS27490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW02_RS27495	COG0584	glycerophosphoryl diester phosphodiesterase
HW02_RS27500	COG2011	ABC-type metal ion transport system permease component
HW02_RS27510	COG1464	Belongs to the NlpA lipoprotein family
HW02_RS27535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW02_RS27540	COG1070	Carbohydrate kinase
HW02_RS27545	COG0246	Mannitol dehydrogenase
HW02_RS27560	COG1175	transmembrane transport
HW02_RS27580	COG4771	TonB-dependent receptor
HW02_RS27595	COG1917	Cupin 2, conserved barrel domain protein
HW02_RS27595	COG4977	sequence-specific DNA binding
HW02_RS27610	COG1116	anion transmembrane transporter activity
HW02_RS27615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS27620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS27640	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS27650	COG3265	gluconokinase activity
HW02_RS27655	COG1609	Transcriptional regulator
HW02_RS27665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS27670	COG0583	DNA-binding transcription factor activity
HW02_RS27690	COG1396	sequence-specific DNA binding
HW02_RS27700	COG2175	clavaminate synthase activity
HW02_RS27710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HW02_RS27715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS27740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS27740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS27750	COG3469	chitinase activity
HW02_RS27755	COG2188	Transcriptional regulator
HW02_RS27760	COG1053	succinate dehydrogenase
HW02_RS27775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS27805	COG4772	TonB-dependent receptor
HW02_RS27850	COG0431	NADPH-dependent FMN reductase
HW02_RS27855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW02_RS27865	COG0640	Transcriptional regulator
HW02_RS27870	COG2207	Transcriptional regulator
HW02_RS27875	COG1064	alcohol dehydrogenase
HW02_RS27900	COG1309	transcriptional regulator
HW02_RS27910	COG2329	Antibiotic biosynthesis monooxygenase
HW02_RS27945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW02_RS27955	COG1609	Transcriptional regulator
HW02_RS27985	COG0252	asparaginase activity
HW02_RS27990	COG1115	amino acid carrier protein
HW02_RS28035	COG1053	succinate dehydrogenase
HW02_RS28045	COG0728	peptidoglycan biosynthetic process
HW02_RS28105	COG2258	MOSC domain
HW02_RS28305	COG4644	lycopene metabolic process
HW02_RS28360	COG2890	protein-(glutamine-N5) methyltransferase activity
HW02_RS28375	COG4191	Histidine kinase
HW02_RS28375	COG0784	Response regulator, receiver
HW02_RS28405	COG1363	Peptidase, m42
HW02_RS28445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HW02_RS28485	COG3568	Endonuclease Exonuclease Phosphatase
HW02_RS28490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW02_RS28495	COG0392	lysyltransferase activity
HW02_RS28505	COG0366	Alpha amylase catalytic
HW02_RS28525	COG1285	pathogenesis
HW02_RS28545	COG0058	SHG alpha-glucan phosphorylase activity
HW02_RS28560	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS28565	COG1546	Belongs to the CinA family
HW02_RS28595	COG2323	membrane
HW02_RS28615	COG3121	Chaperone
HW02_RS28625	COG3188	usher protein
HW02_RS28630	COG3121	Chaperone
HW02_RS28640	COG3969	phosphoadenosine phosphosulfate
HW02_RS28650	COG1475	DNA binding
HW02_RS28655	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS28660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HW02_RS28665	COG0583	DNA-binding transcription factor activity
HW02_RS28685	COG1063	alcohol dehydrogenase
HW02_RS28695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW02_RS28695	COG2169	Transcriptional regulator
HW02_RS28710	COG0583	DNA-binding transcription factor activity
HW02_RS28715	COG2814	Major facilitator Superfamily
HW02_RS28735	COG1984	allophanate hydrolase subunit 2
HW02_RS28745	COG0028	Belongs to the TPP enzyme family
HW02_RS28755	COG0300	oxidoreductase activity
HW02_RS28790	COG2814	Major facilitator Superfamily
HW02_RS28800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS28820	COG0596	Alpha beta hydrolase
HW02_RS28825	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HW02_RS28830	COG0367	asparagine synthase
HW02_RS28840	COG1522	sequence-specific DNA binding
HW02_RS28855	COG1113	amino acid transport
HW02_RS28860	COG2010	Cytochrome c
HW02_RS28865	COG2010	Cytochrome c
HW02_RS28885	COG5001	Diguanylate cyclase
HW02_RS28895	COG4206	TonB-dependent receptor
HW02_RS28900	COG2192	nodulation
HW02_RS28905	COG2814	Major facilitator Superfamily
HW02_RS28935	COG1104	cysteine desulfurase activity
HW02_RS28940	COG4172	Belongs to the ABC transporter superfamily
HW02_RS28945	COG4239	(ABC) transporter, permease
HW02_RS28950	COG4174	ABC transporter (Permease)
HW02_RS28960	COG4771	TonB-dependent receptor
HW02_RS28975	COG0583	DNA-binding transcription factor activity
HW02_RS28995	COG1595	DNA-templated transcription, initiation
HW02_RS29010	COG2207	Transcriptional regulator
HW02_RS29030	COG0564	pseudouridine synthase activity
HW02_RS29040	COG0531	amino acid
HW02_RS29045	COG0174	glutamine synthetase
HW02_RS29080	COG0028	Belongs to the TPP enzyme family
HW02_RS29095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS29115	COG1522	sequence-specific DNA binding
HW02_RS29155	COG1309	transcriptional regulator
HW02_RS29170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS29175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS29185	COG3204	pilus organization
HW02_RS29190	COG0789	Transcriptional regulator
HW02_RS29195	COG1960	acyl-CoA dehydrogenase activity
HW02_RS29200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW02_RS29230	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW02_RS29240	COG2271	Major facilitator Superfamily
HW02_RS29245	COG3290	protein histidine kinase activity
HW02_RS29245	COG3829	transcription factor binding
HW02_RS29250	COG2610	gluconate transmembrane transporter activity
HW02_RS29255	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS29260	COG2031	fatty acid transporter
HW02_RS29275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW02_RS29280	COG0583	DNA-binding transcription factor activity
HW02_RS29285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW02_RS29290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS29310	COG2205	protein histidine kinase activity
HW02_RS29375	COG3851	Histidine kinase
HW02_RS29390	COG0784	Response regulator, receiver
HW02_RS29390	COG2205	protein histidine kinase activity
HW02_RS29410	COG2194	sulfuric ester hydrolase activity
HW02_RS29450	COG0488	(ABC) transporter
HW02_RS29465	COG0583	DNA-binding transcription factor activity
HW02_RS29470	COG1278	Cold shock
HW02_RS29520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW02_RS29525	COG1609	Transcriptional regulator
HW02_RS29530	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW02_RS29535	COG1129	ABC transporter
HW02_RS29560	COG2010	Cytochrome c
HW02_RS29565	COG0753	catalase activity
HW02_RS29595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW02_RS29600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HW02_RS29605	COG2080	2 iron, 2 sulfur cluster binding
HW02_RS29630	COG1944	ATP diphosphatase activity
HW02_RS29650	COG4771	TonB-dependent receptor
HW02_RS29660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW02_RS29660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW02_RS29675	COG0579	oxidoreductase
HW02_RS29710	COG1595	DNA-templated transcription, initiation
HW02_RS29715	COG3712	iron ion homeostasis
HW02_RS29735	COG2814	Major facilitator Superfamily
HW02_RS29785	COG2197	response regulator
HW02_RS29815	COG2366	antibiotic biosynthetic process
HW02_RS29830	COG0625	glutathione transferase activity
HW02_RS29845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS29850	COG0417	DNA replication proofreading
HW02_RS29895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS29965	COG1309	transcriptional regulator
HW02_RS29985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HW02_RS29990	COG0583	DNA-binding transcription factor activity
HW02_RS30000	COG2354	Protein conserved in bacteria
HW02_RS30005	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS30015	COG2239	Acts as a magnesium transporter
HW02_RS30030	COG3706	GGDEF domain
HW02_RS30030	COG4251	negative regulation of phosphorylation
HW02_RS30030	COG5001	Diguanylate cyclase
HW02_RS30030	COG2203	Gaf domain
HW02_RS30035	COG4977	sequence-specific DNA binding
HW02_RS30040	COG3813	Protein conserved in bacteria
HW02_RS30105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS30130	COG0604	alcohol dehydrogenase
HW02_RS30135	COG0616	signal peptide processing
HW02_RS30155	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS30160	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS30165	COG0583	DNA-binding transcription factor activity
HW02_RS30190	COG1024	Enoyl-CoA hydratase
HW02_RS30200	COG0531	amino acid
HW02_RS30215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW02_RS30235	COG0741	lytic transglycosylase activity
HW02_RS30235	COG1388	LysM domain
HW02_RS30240	COG4166	transmembrane transport
HW02_RS30245	COG4166	transmembrane transport
HW02_RS30250	COG4174	ABC transporter (Permease)
HW02_RS30255	COG4239	(ABC) transporter, permease
HW02_RS30260	COG4172	Belongs to the ABC transporter superfamily
HW02_RS30270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS30285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW02_RS30305	COG0745	RESPONSE REGULATOR receiver
HW02_RS30310	COG2205	protein histidine kinase activity
HW02_RS30315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW02_RS30360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW02_RS30380	COG0589	response to stress
HW02_RS30400	COG2201	protein-glutamate methylesterase activity
HW02_RS30410	COG2223	nitrite transmembrane transporter activity
HW02_RS30415	COG0515	serine threonine protein kinase
HW02_RS30420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS30425	COG2146	nitrite reductase [NAD(P)H] activity
HW02_RS30430	COG0243	molybdopterin cofactor binding
HW02_RS30450	COG0668	transmembrane transport
HW02_RS30490	COG0189	ligase activity
HW02_RS30490	COG4067	protein conserved in archaea
HW02_RS30530	COG2909	trisaccharide binding
HW02_RS30535	COG2909	trisaccharide binding
HW02_RS30570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW02_RS30625	COG0519	Catalyzes the synthesis of GMP from XMP
HW02_RS30640	COG0667	Aldo Keto reductase
HW02_RS30655	COG0183	Belongs to the thiolase family
HW02_RS30675	COG1305	Transglutaminase-like
HW02_RS30685	COG2308	Evidence 4 Homologs of previously reported genes of
HW02_RS30690	COG0505	Belongs to the CarA family
HW02_RS30710	COG1317	bacterial-type flagellum organization
HW02_RS30820	COG4789	Type iii secretion
HW02_RS30870	COG4790	Type iii secretion
HW02_RS30875	COG4794	Type iii secretion
HW02_RS30880	COG4791	protein targeting
HW02_RS30885	COG4792	protein secretion
HW02_RS30965	COG2840	Smr protein MutS2
HW02_RS30985	COG2815	serine threonine protein kinase
HW02_RS30985	COG0515	serine threonine protein kinase
HW02_RS31025	COG2204	response regulator
HW02_RS31070	COG0625	glutathione transferase activity
HW02_RS31075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS31090	COG3135	benzoate transporter
HW02_RS31100	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS31105	COG2130	NADP-dependent
HW02_RS31125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW02_RS31165	COG0745	RESPONSE REGULATOR receiver
HW02_RS31170	COG2205	protein histidine kinase activity
HW02_RS31195	COG1960	acyl-CoA dehydrogenase activity
HW02_RS31205	COG1024	Enoyl-CoA hydratase
HW02_RS31210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS31215	COG2186	Transcriptional regulator
HW02_RS31220	COG2807	transmembrane transport
HW02_RS31225	COG0628	permease
HW02_RS31235	COG0625	glutathione transferase activity
HW02_RS31265	COG1022	Amp-dependent synthetase and ligase
HW02_RS31295	COG2205	protein histidine kinase activity
HW02_RS31295	COG0784	Response regulator, receiver
HW02_RS31295	COG5002	protein histidine kinase activity
HW02_RS31335	COG1846	Transcriptional regulator
HW02_RS31340	COG2080	2 iron, 2 sulfur cluster binding
HW02_RS31345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW02_RS31345	COG2010	Cytochrome c
HW02_RS31350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW02_RS31350	COG2010	Cytochrome c
HW02_RS31355	COG2207	Transcriptional regulator
HW02_RS31430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW02_RS31435	COG1053	succinate dehydrogenase
HW02_RS31440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HW02_RS31445	COG2009	succinate dehydrogenase
HW02_RS31475	COG3846	protein secretion by the type IV secretion system
HW02_RS31490	COG3451	type IV secretory pathway VirB4
HW02_RS31500	COG3838	Conjugal transfer protein Trbc
HW02_RS31525	COG0583	DNA-binding transcription factor activity
HW02_RS31560	COG0501	Belongs to the peptidase M48B family
HW02_RS31590	COG1192	Involved in chromosome partitioning
HW02_RS31620	COG5489	Protein of unknown function (DUF736)
HW02_RS31630	COG1475	DNA binding
HW02_RS31650	COG2814	Major facilitator Superfamily
HW02_RS31660	COG4804	nuclease activity
HW02_RS31690	COG2084	Dehydrogenase
HW02_RS31705	COG3738	Protein conserved in bacteria
HW02_RS31730	COG0251	oxidation-reduction process
HW02_RS31735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS31740	COG0174	glutamine synthetase
HW02_RS31745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS31765	COG0840	transmembrane signaling receptor activity
HW02_RS31780	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS31795	COG2010	Cytochrome c
HW02_RS31800	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS31815	COG2010	Cytochrome c
HW02_RS31820	COG0348	domain, Protein
HW02_RS31830	COG2217	Heavy metal translocating P-type atpase
HW02_RS31870	COG2076	Multidrug Resistance protein
HW02_RS31900	COG1960	acyl-CoA dehydrogenase activity
HW02_RS31915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW02_RS31950	COG1196	nuclear chromosome segregation
HW02_RS31980	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS31985	COG1247	-acetyltransferase
HW02_RS32000	COG0582	viral genome integration into host DNA
HW02_RS32015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW02_RS32025	COG0384	phenazine biosynthesis protein PhzF
HW02_RS32055	COG5006	permease, DMT superfamily
HW02_RS32070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW02_RS32085	COG3795	YCII-related domain
HW02_RS32095	COG2814	Major facilitator Superfamily
HW02_RS32100	COG4941	Belongs to the sigma-70 factor family
HW02_RS32110	COG3795	YCII-related domain
HW02_RS32120	COG2197	response regulator
HW02_RS32125	COG1982	Orn Lys Arg decarboxylase major
HW02_RS32130	COG0189	ligase activity
HW02_RS32135	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS32150	COG0765	amino acid transport
HW02_RS32155	COG0765	amino acid transport
HW02_RS32160	COG1126	abc transporter atp-binding protein