locus-tag	class	description
HW02_RS00030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS00055	COG2010	Cytochrome c
HW02_RS00070	COG2818	Glycosylase
HW02_RS00085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HW02_RS00100	COG0569	domain protein
HW02_RS00120	COG1652	LysM domain
HW02_RS00125	COG0758	DNA mediated transformation
HW02_RS00155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS00175	COG3119	arylsulfatase activity
HW02_RS00180	COG0583	DNA-binding transcription factor activity
HW02_RS00215	COG3360	Dodecin
HW02_RS00270	COG3174	membrane
HW02_RS00315	COG0367	asparagine synthase
HW02_RS00335	COG0583	DNA-binding transcription factor activity
HW02_RS00350	COG1764	response to oxidative stress
HW02_RS00385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW02_RS00390	COG0339	signal peptide processing
HW02_RS00395	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HW02_RS00410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HW02_RS00425	COG0515	serine threonine protein kinase
HW02_RS00425	COG2815	serine threonine protein kinase
HW02_RS00430	COG0631	protein serine/threonine phosphatase activity
HW02_RS00445	COG1360	Flagellar Motor Protein
HW02_RS00570	COG0659	secondary active sulfate transmembrane transporter activity
HW02_RS00585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW02_RS00590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW02_RS00595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HW02_RS00635	COG2153	protein acetylation
HW02_RS00675	COG0583	DNA-binding transcription factor activity
HW02_RS00700	COG2824	Alkylphosphonate utilization operon protein PhnA
HW02_RS00730	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS00740	COG3845	ABC transporter
HW02_RS00745	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW02_RS00750	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW02_RS00825	COG0583	DNA-binding transcription factor activity
HW02_RS00830	COG3485	protocatechuate 3,4-dioxygenase
HW02_RS00835	COG3485	protocatechuate 3,4-dioxygenase
HW02_RS00845	COG1414	Transcriptional regulator
HW02_RS00860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS00865	COG0583	DNA-binding transcription factor activity
HW02_RS00900	COG2233	PERMEase
HW02_RS00905	COG1309	transcriptional regulator
HW02_RS00940	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HW02_RS00955	COG0835	chemotaxis
HW02_RS00960	COG2198	Histidine kinase
HW02_RS00960	COG0643	Histidine kinase
HW02_RS00965	COG0745	RESPONSE REGULATOR receiver
HW02_RS00975	COG0583	DNA-binding transcription factor activity
HW02_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS00990	COG1116	anion transmembrane transporter activity
HW02_RS00995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS01000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS01045	COG2175	clavaminate synthase activity
HW02_RS01100	COG1177	transmembrane transport
HW02_RS01105	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS01115	COG0583	DNA-binding transcription factor activity
HW02_RS01150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW02_RS01180	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS01185	COG1113	amino acid transport
HW02_RS01200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS01205	COG0235	Class ii aldolase
HW02_RS01210	COG1396	sequence-specific DNA binding
HW02_RS01215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW02_RS01220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW02_RS01230	COG0477	Major facilitator Superfamily
HW02_RS01240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS01245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS01250	COG0583	DNA-binding transcription factor activity
HW02_RS01270	COG0673	inositol 2-dehydrogenase activity
HW02_RS01290	COG2271	Major facilitator Superfamily
HW02_RS01300	COG1309	transcriptional regulator
HW02_RS01305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW02_RS01315	COG0477	Major facilitator Superfamily
HW02_RS01335	COG2239	Acts as a magnesium transporter
HW02_RS01455	COG0745	RESPONSE REGULATOR receiver
HW02_RS01465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS01480	COG0583	DNA-binding transcription factor activity
HW02_RS01485	COG2807	transmembrane transport
HW02_RS01505	COG0501	Belongs to the peptidase M48B family
HW02_RS01525	COG4208	sulfate ABC transporter
HW02_RS01535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HW02_RS01555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW02_RS01570	COG2199	diguanylate cyclase activity
HW02_RS01595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW02_RS01600	COG0174	glutamine synthetase
HW02_RS01605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW02_RS01610	COG0174	glutamine synthetase
HW02_RS01630	COG3842	ATPase activity
HW02_RS01635	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS01640	COG1177	transmembrane transport
HW02_RS01695	COG0765	amino acid transport
HW02_RS01710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW02_RS01715	COG0277	FAD linked oxidase domain protein
HW02_RS01720	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW02_RS01730	COG3111	PFAM Bacterial OB fold (BOF) protein
HW02_RS01740	COG0531	amino acid
HW02_RS01745	COG2182	Extracellular solute-binding protein
HW02_RS01750	COG1177	transmembrane transport
HW02_RS01760	COG3842	ATPase activity
HW02_RS01770	COG3204	pilus organization
HW02_RS01775	COG2234	aminopeptidase activity
HW02_RS01795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW02_RS01805	COG0702	epimerase
HW02_RS01845	COG0730	response to heat
HW02_RS01880	COG0584	glycerophosphoryl diester phosphodiesterase
HW02_RS01900	COG0622	Phosphoesterase
HW02_RS01905	COG2233	PERMEase
HW02_RS01920	COG0693	protein deglycase activity
HW02_RS01955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW02_RS01965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HW02_RS01990	COG0429	hydrolase of the alpha beta-hydrolase fold
HW02_RS02000	COG0742	ribosomal rna small subunit methyltransferase
HW02_RS02005	COG0612	Peptidase, M16
HW02_RS02010	COG0612	Peptidase, M16
HW02_RS02015	COG0552	protein localization to endoplasmic reticulum
HW02_RS02020	COG2884	Cell division ATP-binding protein ftsE
HW02_RS02025	COG2177	Part of the ABC transporter FtsEX involved in
HW02_RS02045	COG2363	Small membrane protein
HW02_RS02080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW02_RS02095	COG2813	Specifically methylates the guanine in position
HW02_RS02095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS02105	COG1160	GTP binding
HW02_RS02110	COG1872	DUF167
HW02_RS02155	COG0626	cystathionine gamma-synthase activity
HW02_RS02220	COG2198	Histidine kinase
HW02_RS02220	COG0784	Response regulator, receiver
HW02_RS02220	COG0643	Histidine kinase
HW02_RS02250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW02_RS02270	COG3038	cytochrome b561
HW02_RS02300	COG0513	Belongs to the DEAD box helicase family
HW02_RS02310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW02_RS02315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW02_RS02340	COG1309	transcriptional regulator
HW02_RS02345	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS02350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW02_RS02385	COG1953	Uracil, thiamine, allantoin
HW02_RS02400	COG1960	acyl-CoA dehydrogenase activity
HW02_RS02405	COG0583	DNA-binding transcription factor activity
HW02_RS02415	COG0306	phosphate transporter
HW02_RS02425	COG0330	HflC and HflK could
HW02_RS02435	COG1289	transmembrane transporter activity
HW02_RS02440	COG0513	Belongs to the DEAD box helicase family
HW02_RS02450	COG4067	protein conserved in archaea
HW02_RS02450	COG0189	ligase activity
HW02_RS02460	COG0477	Major facilitator Superfamily
HW02_RS02470	COG0542	response to heat
HW02_RS02480	COG0204	Acyl-transferase
HW02_RS02490	COG0745	RESPONSE REGULATOR receiver
HW02_RS02495	COG2205	protein histidine kinase activity
HW02_RS02500	COG4452	Inner membrane protein CreD
HW02_RS02530	COG4774	siderophore transport
HW02_RS02535	COG3712	iron ion homeostasis
HW02_RS02540	COG1595	DNA-templated transcription, initiation
HW02_RS02545	COG0625	glutathione transferase activity
HW02_RS02555	COG1309	transcriptional regulator
HW02_RS02560	COG1953	Uracil, thiamine, allantoin
HW02_RS02580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS02615	COG2005	Transcriptional regulator
HW02_RS02615	COG3585	molybdate ion transport
HW02_RS02620	COG5544	Lipoprotein
HW02_RS02625	COG1040	competence protein
HW02_RS02645	COG0511	ligase activity, forming carbon-carbon bonds
HW02_RS02660	COG1984	allophanate hydrolase subunit 2
HW02_RS02675	COG3121	Chaperone
HW02_RS02690	COG2226	methyltransferase
HW02_RS02690	COG1073	alpha beta
HW02_RS02710	COG1960	acyl-CoA dehydrogenase activity
HW02_RS02715	COG1960	acyl-CoA dehydrogenase activity
HW02_RS02725	COG1960	acyl-CoA dehydrogenase activity
HW02_RS02735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW02_RS02735	COG1648	precorrin-2 dehydrogenase activity
HW02_RS02825	COG0583	DNA-binding transcription factor activity
HW02_RS02830	COG2258	MOSC domain
HW02_RS02840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW02_RS02865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS02875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW02_RS02930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW02_RS02935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW02_RS02945	COG3622	Belongs to the hyi family
HW02_RS02950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW02_RS02990	COG2081	HI0933 family
HW02_RS02995	COG1451	nucleotide metabolic process
HW02_RS03000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW02_RS03005	COG3152	Membrane
HW02_RS03010	COG1917	Cupin 2, conserved barrel domain protein
HW02_RS03010	COG4977	sequence-specific DNA binding
HW02_RS03015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS03080	COG3344	reverse transcriptase
HW02_RS03120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW02_RS03140	COG2719	SpoVR family
HW02_RS03150	COG2766	serine protein kinase
HW02_RS03200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HW02_RS03215	COG2197	response regulator
HW02_RS03225	COG3842	ATPase activity
HW02_RS03235	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS03245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW02_RS03270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW02_RS03355	COG3179	chitinase
HW02_RS03390	COG1765	OsmC-like protein
HW02_RS03405	COG0537	adenosine 5'-monophosphoramidase activity
HW02_RS03415	COG0300	oxidoreductase activity
HW02_RS03430	COG1981	membrane
HW02_RS03460	COG0739	heme binding
HW02_RS03625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW02_RS03750	COG2814	Major facilitator Superfamily
HW02_RS03775	COG1021	2,3-dihydroxybenzoate-AMP ligase
HW02_RS03785	COG3433	isochorismatase activity
HW02_RS03785	COG2226	methyltransferase
HW02_RS03785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS03790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS03790	COG2226	methyltransferase
HW02_RS03790	COG3433	isochorismatase activity
HW02_RS03800	COG1132	(ABC) transporter
HW02_RS03800	COG2375	cellular response to nickel ion
HW02_RS03885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS03890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS03900	COG2706	6-phosphogluconolactonase activity
HW02_RS03920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS03925	COG1960	acyl-CoA dehydrogenase activity
HW02_RS03935	COG4191	Histidine kinase
HW02_RS03940	COG4566	intracellular signal transduction
HW02_RS03945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS03950	COG0765	amino acid transport
HW02_RS03955	COG0765	amino acid transport
HW02_RS03975	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS03980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS03985	COG2271	Major facilitator Superfamily
HW02_RS04035	COG2226	methyltransferase
HW02_RS04045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS04060	COG0251	oxidation-reduction process
HW02_RS04070	COG0693	protein deglycase activity
HW02_RS04075	COG0492	ferredoxin-NADP+ reductase activity
HW02_RS04080	COG1959	2 iron, 2 sulfur cluster binding
HW02_RS04110	COG0154	amidase activity
HW02_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS04125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS04130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS04135	COG4592	Periplasmic binding protein
HW02_RS04140	COG1120	ATPase activity
HW02_RS04150	COG1629	transport
HW02_RS04150	COG4774	siderophore transport
HW02_RS04155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS04160	COG4991	sh3 domain protein
HW02_RS04165	COG1063	alcohol dehydrogenase
HW02_RS04175	COG0022	dehydrogenase e1 component
HW02_RS04180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW02_RS04185	COG3199	ATP-NAD kinase
HW02_RS04195	COG3284	Transcriptional regulator
HW02_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS04390	COG3646	Phage regulatory protein
HW02_RS04400	COG3179	chitinase
HW02_RS04440	COG0740	serine-type endopeptidase activity
HW02_RS04470	COG4968	Prepilin-type N-terminal cleavage methylation domain
HW02_RS04560	COG2814	Major facilitator Superfamily
HW02_RS04565	COG1846	Transcriptional regulator
HW02_RS04575	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS04580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS04590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS04605	COG3971	2-oxopent-4-enoate hydratase activity
HW02_RS04610	COG2271	Major facilitator Superfamily
HW02_RS04620	COG3384	dioxygenase
HW02_RS04625	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS04665	COG1611	Belongs to the LOG family
HW02_RS04710	COG0583	DNA-binding transcription factor activity
HW02_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS04735	COG1063	alcohol dehydrogenase
HW02_RS04740	COG2271	Major facilitator Superfamily
HW02_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS04780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW02_RS04795	COG3121	Chaperone
HW02_RS04820	COG2197	response regulator
HW02_RS04860	COG0531	amino acid
HW02_RS04880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW02_RS04890	COG3047	cAMP biosynthetic process
HW02_RS04920	COG3118	belongs to the thioredoxin family
HW02_RS04925	COG2264	protein methyltransferase activity
HW02_RS04945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW02_RS04945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW02_RS04970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HW02_RS04975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW02_RS04985	COG3577	Aspartyl protease
HW02_RS05010	COG0142	geranyltranstransferase activity
HW02_RS05020	COG4948	Mandelate Racemase Muconate Lactonizing
HW02_RS05040	COG1131	(ABC) transporter
HW02_RS05065	COG0745	RESPONSE REGULATOR receiver
HW02_RS05075	COG3228	Belongs to the MtfA family
HW02_RS05080	COG0586	Pfam SNARE associated Golgi protein
HW02_RS05095	COG0456	acetyltransferase
HW02_RS05105	COG4303	Ethanolamine ammonia lyase large subunit
HW02_RS05110	COG0531	amino acid
HW02_RS05120	COG3284	Transcriptional regulator
HW02_RS05125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW02_RS05140	COG0702	epimerase
HW02_RS05160	COG1346	cytolysis
HW02_RS05170	COG0586	Pfam SNARE associated Golgi protein
HW02_RS05210	COG0768	penicillin binding
HW02_RS05215	COG0772	Belongs to the SEDS family
HW02_RS05220	COG2951	lytic endotransglycosylase activity
HW02_RS05230	COG1686	Belongs to the peptidase S11 family
HW02_RS05260	COG2951	lytic endotransglycosylase activity
HW02_RS05295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HW02_RS05305	COG4535	Mg2 and Co2 transporter CorC
HW02_RS05315	COG1702	phosphate starvation-inducible protein PhoH
HW02_RS05345	COG0351	phosphomethylpyrimidine kinase
HW02_RS05350	COG2198	Histidine kinase
HW02_RS05350	COG0784	Response regulator, receiver
HW02_RS05350	COG2205	protein histidine kinase activity
HW02_RS05360	COG1960	acyl-CoA dehydrogenase activity
HW02_RS05370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW02_RS05410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW02_RS05420	COG1643	Atp-dependent helicase
HW02_RS05465	COG3416	Protein conserved in bacteria
HW02_RS05475	COG0513	Belongs to the DEAD box helicase family
HW02_RS05490	COG2197	response regulator
HW02_RS05495	COG2202	Pas domain
HW02_RS05495	COG2200	EAL domain
HW02_RS05495	COG2199	diguanylate cyclase activity
HW02_RS05500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS05500	COG2205	protein histidine kinase activity
HW02_RS05520	COG1946	Acyl-CoA thioesterase
HW02_RS05540	COG4521	taurine ABC transporter
HW02_RS05550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS05555	COG2175	clavaminate synthase activity
HW02_RS05560	COG1297	OPT oligopeptide transporter protein
HW02_RS05565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW02_RS05580	COG1271	oxidase subunit
HW02_RS05585	COG1294	oxidase, subunit
HW02_RS05595	COG2207	Transcriptional regulator
HW02_RS05605	COG0183	Belongs to the thiolase family
HW02_RS05610	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS05645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW02_RS05655	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HW02_RS05665	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW02_RS05670	COG0303	'Molybdopterin
HW02_RS05675	COG0826	peptidase U32
HW02_RS05680	COG0826	peptidase U32
HW02_RS05685	COG3154	lipid carrier protein
HW02_RS05735	COG4772	TonB-dependent receptor
HW02_RS05740	COG3712	iron ion homeostasis
HW02_RS05745	COG1595	DNA-templated transcription, initiation
HW02_RS05755	COG0697	spore germination
HW02_RS05765	COG0583	DNA-binding transcription factor activity
HW02_RS05785	COG1566	PFAM secretion protein HlyD family protein
HW02_RS05840	COG0300	oxidoreductase activity
HW02_RS05845	COG2226	methyltransferase
HW02_RS05860	COG2197	response regulator
HW02_RS05865	COG3850	Histidine kinase
HW02_RS05875	COG2223	nitrite transmembrane transporter activity
HW02_RS05880	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW02_RS05885	COG1140	nitrate reductase beta subunit
HW02_RS05890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW02_RS05895	COG2181	nitrate reductase activity
HW02_RS05900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS05910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS05940	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS05950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS06015	COG0583	DNA-binding transcription factor activity
HW02_RS06050	COG0490	domain, Protein
HW02_RS06050	COG0471	metal ion transport
HW02_RS06055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HW02_RS06060	COG4120	Belongs to the binding-protein-dependent transport system permease family
HW02_RS06105	COG0795	lipopolysaccharide-transporting ATPase activity
HW02_RS06110	COG0795	lipopolysaccharide-transporting ATPase activity
HW02_RS06120	COG2200	EAL domain
HW02_RS06125	COG1278	Cold shock
HW02_RS06155	COG1862	Preprotein translocase
HW02_RS06170	COG3134	Outer membrane lipoprotein
HW02_RS06185	COG1045	serine acetyltransferase
HW02_RS06275	COG0436	Aminotransferase
HW02_RS06290	COG0667	Aldo Keto reductase
HW02_RS06330	COG0739	heme binding
HW02_RS06340	COG2847	Copper chaperone PCu(A)C
HW02_RS06350	COG1335	isochorismatase
HW02_RS06365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW02_RS06375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW02_RS06380	COG0583	DNA-binding transcription factor activity
HW02_RS06440	COG0738	Major facilitator superfamily
HW02_RS06450	COG2130	NADP-dependent
HW02_RS06455	COG2132	Multicopper oxidase
HW02_RS06460	COG0590	tRNA wobble adenosine to inosine editing
HW02_RS06505	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW02_RS06505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW02_RS06510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW02_RS06515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW02_RS06520	COG2188	Transcriptional regulator
HW02_RS06560	COG0477	Major facilitator Superfamily
HW02_RS06565	COG4536	flavin adenine dinucleotide binding
HW02_RS06575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW02_RS06600	COG1607	acyl-coa hydrolase
HW02_RS06620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW02_RS06645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW02_RS06685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW02_RS06695	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS06740	COG2197	response regulator
HW02_RS06745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW02_RS06765	COG0477	Major facilitator Superfamily
HW02_RS06800	COG5001	Diguanylate cyclase
HW02_RS06800	COG4251	negative regulation of phosphorylation
HW02_RS06800	COG3706	GGDEF domain
HW02_RS06800	COG2203	Gaf domain
HW02_RS06835	COG3064	Membrane
HW02_RS06835	COG1073	alpha beta
HW02_RS06835	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HW02_RS06850	COG2885	chlorophyll binding
HW02_RS06865	COG0789	Transcriptional regulator
HW02_RS06885	COG1214	PFAM Peptidase M22, glycoprotease
HW02_RS06895	COG1801	Protein of unknown function DUF72
HW02_RS06900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HW02_RS06925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS06970	COG2166	iron-sulfur cluster assembly
HW02_RS06985	COG1280	lysine exporter protein (LysE YggA)
HW02_RS06990	COG1393	Belongs to the ArsC family
HW02_RS07010	COG0025	NhaP-type Na H and K H
HW02_RS07015	COG0436	Aminotransferase
HW02_RS07025	COG0024	Methionine aminopeptidase
HW02_RS07070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW02_RS07105	COG1115	amino acid carrier protein
HW02_RS07155	COG2391	methyltransferase activity
HW02_RS07160	COG0583	DNA-binding transcription factor activity
HW02_RS07165	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HW02_RS07170	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HW02_RS07225	COG1546	Belongs to the CinA family
HW02_RS07245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW02_RS07250	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HW02_RS07255	COG3530	Putative quorum-sensing-regulated virulence factor
HW02_RS07270	COG1177	transmembrane transport
HW02_RS07275	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS07285	COG3148	PFAM DTW domain containing protein
HW02_RS07330	COG0531	amino acid
HW02_RS07335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW02_RS07335	COG2169	Transcriptional regulator
HW02_RS07340	COG0477	Major facilitator Superfamily
HW02_RS07350	COG0583	DNA-binding transcription factor activity
HW02_RS07355	COG1960	acyl-CoA dehydrogenase activity
HW02_RS07360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW02_RS07365	COG1024	Enoyl-CoA hydratase
HW02_RS07370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS07375	COG0183	Belongs to the thiolase family
HW02_RS07385	COG0583	DNA-binding transcription factor activity
HW02_RS07425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW02_RS07470	COG2814	Major facilitator Superfamily
HW02_RS07510	COG0583	DNA-binding transcription factor activity
HW02_RS07545	COG0084	hydrolase, TatD family'
HW02_RS07550	COG1609	Transcriptional regulator
HW02_RS07560	COG1105	Belongs to the carbohydrate kinase PfkB family
HW02_RS07565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW02_RS07565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW02_RS07565	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HW02_RS07680	COG3842	ATPase activity
HW02_RS07700	COG0243	molybdopterin cofactor binding
HW02_RS07705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HW02_RS07710	COG2223	nitrite transmembrane transporter activity
HW02_RS07725	COG0450	alkyl hydroperoxide reductase
HW02_RS07755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS07780	COG5566	PFAM Mor transcription activator
HW02_RS07840	COG0488	(ABC) transporter
HW02_RS07915	COG0640	Transcriptional regulator
HW02_RS07925	COG4373	Mu-like prophage FluMu protein gp28
HW02_RS07930	COG4383	Mu-like prophage protein gp29
HW02_RS07955	COG4397	Mu-like prophage major head subunit gpT
HW02_RS08065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW02_RS08070	COG2264	protein methyltransferase activity
HW02_RS08080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW02_RS08135	COG0489	protein tyrosine kinase activity
HW02_RS08185	COG0791	NLP P60 protein
HW02_RS08205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW02_RS08210	COG0668	transmembrane transport
HW02_RS08215	COG0477	Major facilitator Superfamily
HW02_RS08220	COG0513	Belongs to the DEAD box helicase family
HW02_RS08240	COG0784	Response regulator, receiver
HW02_RS08240	COG2205	protein histidine kinase activity
HW02_RS08240	COG5002	protein histidine kinase activity
HW02_RS08245	COG1363	Peptidase, m42
HW02_RS08250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW02_RS08250	COG0189	ligase activity
HW02_RS08255	COG0367	asparagine synthase
HW02_RS08285	COG0183	Belongs to the thiolase family
HW02_RS08305	COG0450	alkyl hydroperoxide reductase
HW02_RS08310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS08315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS08325	COG0431	NADPH-dependent FMN reductase
HW02_RS08330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS08340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS08365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW02_RS08390	COG0583	DNA-binding transcription factor activity
HW02_RS08395	COG1380	Effector of murein hydrolase LrgA
HW02_RS08400	COG1346	cytolysis
HW02_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS08425	COG1024	Enoyl-CoA hydratase
HW02_RS08435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW02_RS08480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW02_RS08520	COG1629	transport
HW02_RS08575	COG0583	DNA-binding transcription factor activity
HW02_RS08650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW02_RS08655	COG3639	organic phosphonate transmembrane transporter activity
HW02_RS08660	COG2188	Transcriptional regulator
HW02_RS08665	COG3624	Phosphonate C-P lyase system protein PhnG
HW02_RS08675	COG3626	phosphonate metabolism
HW02_RS08680	COG3627	carbon phosphorus lyase activity
HW02_RS08685	COG4107	phosphonate C-P lyase system protein PhnK
HW02_RS08690	COG4778	phosphonate C-P lyase system protein PhnL
HW02_RS08695	COG3454	Phosphonate metabolism
HW02_RS08705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW02_RS08825	COG0697	spore germination
HW02_RS08850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HW02_RS08870	COG0784	Response regulator, receiver
HW02_RS08870	COG0835	chemotaxis
HW02_RS08885	COG0745	RESPONSE REGULATOR receiver
HW02_RS08895	COG0514	ATP-dependent DNA helicase (RecQ)
HW02_RS08900	COG4251	negative regulation of phosphorylation
HW02_RS08900	COG2203	Gaf domain
HW02_RS08900	COG5001	Diguanylate cyclase
HW02_RS08900	COG3706	GGDEF domain
HW02_RS08925	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW02_RS08965	COG2124	cytochrome p450
HW02_RS08970	COG4221	oxidoreductase activity
HW02_RS08985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS09015	COG0583	DNA-binding transcription factor activity
HW02_RS09045	COG3639	organic phosphonate transmembrane transporter activity
HW02_RS09055	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW02_RS09060	COG2084	Dehydrogenase
HW02_RS09075	COG0589	response to stress
HW02_RS09115	COG2814	Major facilitator Superfamily
HW02_RS09120	COG2030	dehydratase
HW02_RS09125	COG2267	carboxylic ester hydrolase activity
HW02_RS09130	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS09135	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS09150	COG1643	Atp-dependent helicase
HW02_RS09160	COG0537	adenosine 5'-monophosphoramidase activity
HW02_RS09210	COG1595	DNA-templated transcription, initiation
HW02_RS09285	COG1201	RNA secondary structure unwinding
HW02_RS09290	COG0784	Response regulator, receiver
HW02_RS09290	COG2205	protein histidine kinase activity
HW02_RS09305	COG4772	TonB-dependent receptor
HW02_RS09320	COG2076	Multidrug Resistance protein
HW02_RS09325	COG0385	Bile acid
HW02_RS09375	COG2200	EAL domain
HW02_RS09385	COG3321	synthase
HW02_RS09385	COG0604	alcohol dehydrogenase
HW02_RS09390	COG0560	Phosphoserine phosphatase
HW02_RS09405	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW02_RS09435	COG0564	pseudouridine synthase activity
HW02_RS09445	COG2894	cell division
HW02_RS09455	COG1560	Kdo2-lipid A biosynthetic process
HW02_RS09470	COG2853	Lipoprotein
HW02_RS09490	COG3162	membrane
HW02_RS09495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW02_RS09525	COG1132	(ABC) transporter
HW02_RS09535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW02_RS09560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW02_RS09575	COG0438	transferase activity, transferring glycosyl groups
HW02_RS09575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW02_RS09605	COG1127	ABC transporter
HW02_RS09610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW02_RS09615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW02_RS09620	COG0727	PFAM Uncharacterised protein family (UPF0153)
HW02_RS09625	COG0778	Nitroreductase
HW02_RS09645	COG0745	RESPONSE REGULATOR receiver
HW02_RS09655	COG2350	Protein conserved in bacteria
HW02_RS09665	COG0613	PHP domain protein
HW02_RS09670	COG0009	L-threonylcarbamoyladenylate synthase
HW02_RS09675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW02_RS09680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW02_RS09730	COG1175	transmembrane transport
HW02_RS09735	COG0395	ABC-type sugar transport system, permease component
HW02_RS09740	COG3842	ATPase activity
HW02_RS09755	COG0676	glucose-6-phosphate 1-epimerase activity
HW02_RS09800	COG0786	glutamate:sodium symporter activity
HW02_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS09830	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS09860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW02_RS09890	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW02_RS09910	COG0367	asparagine synthase
HW02_RS09925	COG0438	transferase activity, transferring glycosyl groups
HW02_RS09930	COG0438	transferase activity, transferring glycosyl groups
HW02_RS09940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW02_RS09980	COG0583	DNA-binding transcription factor activity
HW02_RS10015	COG0596	Alpha beta hydrolase
HW02_RS10020	COG0800	Aldolase
HW02_RS10035	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS10055	COG0583	DNA-binding transcription factor activity
HW02_RS10060	COG0251	oxidation-reduction process
HW02_RS10080	COG2226	methyltransferase
HW02_RS10120	COG0285	dihydrofolate synthase activity
HW02_RS10125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW02_RS10130	COG1286	toxin biosynthetic process
HW02_RS10230	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS10230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS10255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW02_RS10265	COG3139	Protein of unknown function (DUF1315)
HW02_RS10275	COG0308	aminopeptidase N
HW02_RS10310	COG0745	RESPONSE REGULATOR receiver
HW02_RS10345	COG0714	Associated with various cellular activities
HW02_RS10365	COG1335	isochorismatase
HW02_RS10375	COG2342	PFAM TM1410 hypothetical-related protein
HW02_RS10400	COG0297	glycogen (starch) synthase activity
HW02_RS10450	COG3130	regulation of translation
HW02_RS10465	COG2027	D-alanyl-D-alanine carboxypeptidase
HW02_RS10470	COG3171	Protein conserved in bacteria
HW02_RS10475	COG2197	response regulator
HW02_RS10535	COG4644	lycopene metabolic process
HW02_RS10540	COG2205	protein histidine kinase activity
HW02_RS10540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS10565	COG0004	ammonium transporteR
HW02_RS10575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS10585	COG0625	glutathione transferase activity
HW02_RS10590	COG1309	transcriptional regulator
HW02_RS10620	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW02_RS10640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW02_RS10645	COG1070	Carbohydrate kinase
HW02_RS10665	COG0741	lytic transglycosylase activity
HW02_RS10670	COG0488	(ABC) transporter
HW02_RS10680	COG0589	response to stress
HW02_RS10760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW02_RS10770	COG1113	amino acid transport
HW02_RS10805	COG1477	protein flavinylation
HW02_RS10820	COG0584	glycerophosphoryl diester phosphodiesterase
HW02_RS10835	COG4591	ABC-type transport system involved in lipoprotein release permease component
HW02_RS10855	COG0658	competence protein
HW02_RS10855	COG2333	competence protein COMEC
HW02_RS10860	COG0811	peptide transport
HW02_RS10865	COG0848	biopolymer transport protein
HW02_RS10885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW02_RS10895	COG1530	ribonuclease E activity
HW02_RS10910	COG0546	phosphoglycolate phosphatase activity
HW02_RS10915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW02_RS10915	COG0616	signal peptide processing
HW02_RS10925	COG1399	metal-binding, possibly nucleic acid-binding protein
HW02_RS10955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW02_RS10965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW02_RS10985	COG0084	hydrolase, TatD family'
HW02_RS11070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW02_RS11085	COG0183	Belongs to the thiolase family
HW02_RS11100	COG2233	PERMEase
HW02_RS11125	COG2814	Major facilitator Superfamily
HW02_RS11130	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS11135	COG1309	transcriptional regulator
HW02_RS11170	COG4160	amino acid transport
HW02_RS11175	COG4215	(ABC) transporter
HW02_RS11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS11185	COG1473	amidohydrolase
HW02_RS11190	COG0583	DNA-binding transcription factor activity
HW02_RS11195	COG0840	transmembrane signaling receptor activity
HW02_RS11225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS11235	COG1120	ATPase activity
HW02_RS11265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS11295	COG3047	cAMP biosynthetic process
HW02_RS11295	COG2885	chlorophyll binding
HW02_RS11300	COG2197	response regulator
HW02_RS11310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS11315	COG1595	DNA-templated transcription, initiation
HW02_RS11330	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS11345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW02_RS11350	COG1960	acyl-CoA dehydrogenase activity
HW02_RS11355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW02_RS11370	COG1309	transcriptional regulator
HW02_RS11400	COG0583	DNA-binding transcription factor activity
HW02_RS11410	COG0583	DNA-binding transcription factor activity
HW02_RS11420	COG0714	Associated with various cellular activities
HW02_RS11465	COG0084	hydrolase, TatD family'
HW02_RS11470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW02_RS11475	COG2259	Doxx family
HW02_RS11490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW02_RS11505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HW02_RS11510	COG4181	ATPase activity
HW02_RS11550	COG1764	response to oxidative stress
HW02_RS11555	COG1846	Transcriptional regulator
HW02_RS11560	COG0583	DNA-binding transcription factor activity
HW02_RS11570	COG0583	DNA-binding transcription factor activity
HW02_RS11580	COG3214	Protein conserved in bacteria
HW02_RS11585	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HW02_RS11595	COG1024	Enoyl-CoA hydratase
HW02_RS11605	COG3384	dioxygenase
HW02_RS11645	COG2866	Carboxypeptidase
HW02_RS11660	COG0436	Aminotransferase
HW02_RS11670	COG0386	Belongs to the glutathione peroxidase family
HW02_RS11675	COG1846	Transcriptional regulator
HW02_RS11680	COG0784	Response regulator, receiver
HW02_RS11680	COG2205	protein histidine kinase activity
HW02_RS11680	COG5002	protein histidine kinase activity
HW02_RS11685	COG2255	four-way junction helicase activity
HW02_RS11690	COG1956	GAF domain-containing protein
HW02_RS11695	COG0625	glutathione transferase activity
HW02_RS11720	COG0582	viral genome integration into host DNA
HW02_RS11765	COG1396	sequence-specific DNA binding
HW02_RS11770	COG0583	DNA-binding transcription factor activity
HW02_RS11810	COG2132	Multicopper oxidase
HW02_RS11815	COG0745	RESPONSE REGULATOR receiver
HW02_RS11820	COG5002	protein histidine kinase activity
HW02_RS11840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW02_RS11845	COG0789	Transcriptional regulator
HW02_RS11850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW02_RS11855	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HW02_RS11870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HW02_RS11875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW02_RS11895	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HW02_RS11900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW02_RS11910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW02_RS11925	COG2217	Heavy metal translocating P-type atpase
HW02_RS11930	COG2326	polyphosphate kinase activity
HW02_RS12010	COG2003	Belongs to the UPF0758 family
HW02_RS12065	COG3311	Transcriptional regulator
HW02_RS12070	COG1569	PIN domain
HW02_RS12075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW02_RS12140	COG0640	Transcriptional regulator
HW02_RS12150	COG0798	PFAM Bile acid sodium symporter
HW02_RS12155	COG1393	Belongs to the ArsC family
HW02_RS12160	COG0431	NADPH-dependent FMN reductase
HW02_RS12245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW02_RS12255	COG0789	Transcriptional regulator
HW02_RS12275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS12280	COG0629	single-stranded DNA binding
HW02_RS12335	COG2200	EAL domain
HW02_RS12360	COG0625	glutathione transferase activity
HW02_RS12365	COG1131	(ABC) transporter
HW02_RS12370	COG0842	Transport permease protein
HW02_RS12415	COG2188	Transcriptional regulator
HW02_RS12425	COG2853	Lipoprotein
HW02_RS12435	COG0745	RESPONSE REGULATOR receiver
HW02_RS12455	COG1335	isochorismatase
HW02_RS12485	COG5434	Belongs to the glycosyl hydrolase 28 family
HW02_RS12515	COG3655	Transcriptional regulator
HW02_RS12560	COG2116	formate transmembrane transporter activity
HW02_RS12565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS12630	COG4644	lycopene metabolic process
HW02_RS12670	COG0789	Transcriptional regulator
HW02_RS12680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW02_RS12705	COG4372	Transposase
HW02_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS12785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW02_RS12800	COG0589	response to stress
HW02_RS12805	COG0659	secondary active sulfate transmembrane transporter activity
HW02_RS12845	COG1061	Type III restriction enzyme res subunit
HW02_RS12870	COG0024	Methionine aminopeptidase
HW02_RS12965	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW02_RS12965	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW02_RS12975	COG0542	response to heat
HW02_RS13010	COG0789	Transcriptional regulator
HW02_RS13020	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS13020	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS13025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW02_RS13030	COG0243	molybdopterin cofactor binding
HW02_RS13055	COG1280	lysine exporter protein (LysE YggA)
HW02_RS13070	COG0542	response to heat
HW02_RS13145	COG1607	acyl-coa hydrolase
HW02_RS13150	COG1959	2 iron, 2 sulfur cluster binding
HW02_RS13165	COG2819	hydrolase of the alpha beta superfamily
HW02_RS13210	COG0583	DNA-binding transcription factor activity
HW02_RS13220	COG4106	trans-aconitate 2-methyltransferase activity
HW02_RS13230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS13235	COG1459	type II secretion system
HW02_RS13245	COG2165	general secretion pathway protein
HW02_RS13285	COG0720	synthase
HW02_RS13290	COG3604	Transcriptional regulator
HW02_RS13350	COG0840	transmembrane signaling receptor activity
HW02_RS13355	COG2056	Na+-H+ antiporter family
HW02_RS13375	COG2226	methyltransferase
HW02_RS13475	COG2153	protein acetylation
HW02_RS13480	COG2850	peptidyl-arginine hydroxylation
HW02_RS13520	COG1278	Cold shock
HW02_RS13530	COG0542	response to heat
HW02_RS13535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW02_RS13550	COG0492	ferredoxin-NADP+ reductase activity
HW02_RS13565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW02_RS13580	COG0435	Glutathione S-transferase
HW02_RS13585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW02_RS13590	COG2920	part of a sulfur-relay system
HW02_RS13630	COG0583	DNA-binding transcription factor activity
HW02_RS13635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS13640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS13650	COG1960	acyl-CoA dehydrogenase activity
HW02_RS13655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS13665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS13670	COG3424	synthase
HW02_RS13680	COG0583	DNA-binding transcription factor activity
HW02_RS13710	COG1960	acyl-CoA dehydrogenase activity
HW02_RS13715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS13725	COG1309	transcriptional regulator
HW02_RS13735	COG1131	(ABC) transporter
HW02_RS13740	COG0842	Transport permease protein
HW02_RS13745	COG0842	Transport permease protein
HW02_RS13770	COG2197	response regulator
HW02_RS13775	COG4771	TonB-dependent receptor
HW02_RS13830	COG2205	protein histidine kinase activity
HW02_RS13830	COG0784	Response regulator, receiver
HW02_RS13830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS13830	COG2198	Histidine kinase
HW02_RS13850	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS13865	COG1522	sequence-specific DNA binding
HW02_RS13895	COG4191	Histidine kinase
HW02_RS13920	COG4251	negative regulation of phosphorylation
HW02_RS13920	COG5001	Diguanylate cyclase
HW02_RS13920	COG3706	GGDEF domain
HW02_RS13920	COG2203	Gaf domain
HW02_RS13930	COG0659	secondary active sulfate transmembrane transporter activity
HW02_RS13965	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS13975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW02_RS13985	COG0183	Belongs to the thiolase family
HW02_RS13990	COG1960	acyl-CoA dehydrogenase activity
HW02_RS14040	COG0729	surface antigen
HW02_RS14050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW02_RS14055	COG2267	carboxylic ester hydrolase activity
HW02_RS14060	COG0671	phosphoesterase, PA-phosphatase related
HW02_RS14060	COG2453	phosphatase
HW02_RS14075	COG4589	Belongs to the CDS family
HW02_RS14080	COG0667	Aldo Keto reductase
HW02_RS14090	COG1115	amino acid carrier protein
HW02_RS14100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW02_RS14130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS14135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS14140	COG1538	Outer membrane efflux protein
HW02_RS14200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW02_RS14200	COG0543	2 iron, 2 sulfur cluster binding
HW02_RS14205	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HW02_RS14210	COG4638	Rieske (2fe-2S)
HW02_RS14235	COG4948	Mandelate Racemase Muconate Lactonizing
HW02_RS14245	COG3485	protocatechuate 3,4-dioxygenase
HW02_RS14280	COG2807	transmembrane transport
HW02_RS14285	COG0590	tRNA wobble adenosine to inosine editing
HW02_RS14300	COG2318	DinB family
HW02_RS14375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS14380	COG2863	cytochrome
HW02_RS14385	COG3258	Cytochrome c
HW02_RS14390	COG0642	Histidine kinase
HW02_RS14425	COG0625	glutathione transferase activity
HW02_RS14445	COG0583	DNA-binding transcription factor activity
HW02_RS14450	COG1595	DNA-templated transcription, initiation
HW02_RS14455	COG3712	iron ion homeostasis
HW02_RS14520	COG2382	esterase
HW02_RS14540	COG0583	DNA-binding transcription factor activity
HW02_RS14565	COG1760	l-serine dehydratase
HW02_RS14570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW02_RS14605	COG2217	Heavy metal translocating P-type atpase
HW02_RS14620	COG0583	DNA-binding transcription factor activity
HW02_RS14640	COG1566	PFAM secretion protein HlyD family protein
HW02_RS14695	COG1335	isochorismatase
HW02_RS14705	COG0583	DNA-binding transcription factor activity
HW02_RS14745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW02_RS14750	COG1121	(ABC) transporter
HW02_RS14790	COG0657	acetylesterase activity
HW02_RS14795	COG4774	siderophore transport
HW02_RS14840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS14865	COG0735	belongs to the Fur family
HW02_RS14875	COG1304	FMN binding
HW02_RS14905	COG4566	intracellular signal transduction
HW02_RS14995	COG3829	transcription factor binding
HW02_RS15020	COG3829	transcription factor binding
HW02_RS15025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW02_RS15030	COG0584	glycerophosphoryl diester phosphodiesterase
HW02_RS15035	COG2011	ABC-type metal ion transport system permease component
HW02_RS15045	COG1464	Belongs to the NlpA lipoprotein family
HW02_RS15075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW02_RS15080	COG1070	Carbohydrate kinase
HW02_RS15085	COG0246	Mannitol dehydrogenase
HW02_RS15100	COG1175	transmembrane transport
HW02_RS15120	COG4771	TonB-dependent receptor
HW02_RS15135	COG4977	sequence-specific DNA binding
HW02_RS15135	COG1917	Cupin 2, conserved barrel domain protein
HW02_RS15150	COG1116	anion transmembrane transporter activity
HW02_RS15155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW02_RS15160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS15180	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS15195	COG3265	gluconokinase activity
HW02_RS15200	COG1609	Transcriptional regulator
HW02_RS15210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS15215	COG0583	DNA-binding transcription factor activity
HW02_RS15235	COG1396	sequence-specific DNA binding
HW02_RS15245	COG2175	clavaminate synthase activity
HW02_RS15255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HW02_RS15260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS15285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS15285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW02_RS15295	COG3469	chitinase activity
HW02_RS15300	COG2188	Transcriptional regulator
HW02_RS15305	COG1053	succinate dehydrogenase
HW02_RS15320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW02_RS15355	COG4772	TonB-dependent receptor
HW02_RS15400	COG0431	NADPH-dependent FMN reductase
HW02_RS15405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW02_RS15415	COG0640	Transcriptional regulator
HW02_RS15420	COG2207	Transcriptional regulator
HW02_RS15425	COG1064	alcohol dehydrogenase
HW02_RS15450	COG1309	transcriptional regulator
HW02_RS15460	COG2329	Antibiotic biosynthesis monooxygenase
HW02_RS15495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW02_RS15505	COG1609	Transcriptional regulator
HW02_RS15540	COG0252	asparaginase activity
HW02_RS15545	COG1115	amino acid carrier protein
HW02_RS15590	COG1053	succinate dehydrogenase
HW02_RS15600	COG0728	peptidoglycan biosynthetic process
HW02_RS15665	COG2258	MOSC domain
HW02_RS15880	COG4644	lycopene metabolic process
HW02_RS15940	COG2890	protein-(glutamine-N5) methyltransferase activity
HW02_RS15955	COG0784	Response regulator, receiver
HW02_RS15955	COG4191	Histidine kinase
HW02_RS15985	COG1363	Peptidase, m42
HW02_RS16030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HW02_RS16075	COG3568	Endonuclease Exonuclease Phosphatase
HW02_RS16080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW02_RS16085	COG0392	lysyltransferase activity
HW02_RS16095	COG0366	Alpha amylase catalytic
HW02_RS16115	COG1285	pathogenesis
HW02_RS16140	COG0058	SHG alpha-glucan phosphorylase activity
HW02_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS16190	COG2323	membrane
HW02_RS16210	COG3121	Chaperone
HW02_RS16220	COG3188	usher protein
HW02_RS16225	COG3121	Chaperone
HW02_RS16235	COG3969	phosphoadenosine phosphosulfate
HW02_RS16245	COG1475	DNA binding
HW02_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS16255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HW02_RS16260	COG0583	DNA-binding transcription factor activity
HW02_RS16280	COG1063	alcohol dehydrogenase
HW02_RS16295	COG2169	Transcriptional regulator
HW02_RS16295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW02_RS16315	COG0583	DNA-binding transcription factor activity
HW02_RS16320	COG2814	Major facilitator Superfamily
HW02_RS16340	COG1984	allophanate hydrolase subunit 2
HW02_RS16350	COG0028	Belongs to the TPP enzyme family
HW02_RS16360	COG0300	oxidoreductase activity
HW02_RS16400	COG2814	Major facilitator Superfamily
HW02_RS16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW02_RS16430	COG0596	Alpha beta hydrolase
HW02_RS16435	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HW02_RS16440	COG0367	asparagine synthase
HW02_RS16450	COG1522	sequence-specific DNA binding
HW02_RS16470	COG1113	amino acid transport
HW02_RS16480	COG2010	Cytochrome c
HW02_RS16485	COG2010	Cytochrome c
HW02_RS16510	COG5001	Diguanylate cyclase
HW02_RS16520	COG4206	TonB-dependent receptor
HW02_RS16530	COG2192	nodulation
HW02_RS16535	COG2814	Major facilitator Superfamily
HW02_RS16565	COG1104	cysteine desulfurase activity
HW02_RS16570	COG4172	Belongs to the ABC transporter superfamily
HW02_RS16575	COG4239	(ABC) transporter, permease
HW02_RS16580	COG4174	ABC transporter (Permease)
HW02_RS16590	COG4771	TonB-dependent receptor
HW02_RS16605	COG0583	DNA-binding transcription factor activity
HW02_RS16625	COG1595	DNA-templated transcription, initiation
HW02_RS16640	COG2207	Transcriptional regulator
HW02_RS16660	COG0564	pseudouridine synthase activity
HW02_RS16675	COG0531	amino acid
HW02_RS16680	COG0174	glutamine synthetase
HW02_RS16715	COG0028	Belongs to the TPP enzyme family
HW02_RS16730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS16750	COG1522	sequence-specific DNA binding
HW02_RS16790	COG1309	transcriptional regulator
HW02_RS16805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS16810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS16820	COG3204	pilus organization
HW02_RS16825	COG0789	Transcriptional regulator
HW02_RS16830	COG1960	acyl-CoA dehydrogenase activity
HW02_RS16835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW02_RS16865	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW02_RS16875	COG2271	Major facilitator Superfamily
HW02_RS16880	COG3829	transcription factor binding
HW02_RS16880	COG3290	protein histidine kinase activity
HW02_RS16885	COG2610	gluconate transmembrane transporter activity
HW02_RS16890	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS16895	COG2031	fatty acid transporter
HW02_RS16910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW02_RS16915	COG0583	DNA-binding transcription factor activity
HW02_RS16920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW02_RS16925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS16945	COG2205	protein histidine kinase activity
HW02_RS17010	COG3851	Histidine kinase
HW02_RS17025	COG0784	Response regulator, receiver
HW02_RS17025	COG2205	protein histidine kinase activity
HW02_RS17045	COG2194	sulfuric ester hydrolase activity
HW02_RS17090	COG0488	(ABC) transporter
HW02_RS17105	COG0583	DNA-binding transcription factor activity
HW02_RS17110	COG1278	Cold shock
HW02_RS17160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW02_RS17165	COG1609	Transcriptional regulator
HW02_RS17170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW02_RS17175	COG1129	ABC transporter
HW02_RS17205	COG2010	Cytochrome c
HW02_RS17210	COG0753	catalase activity
HW02_RS17245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW02_RS17250	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HW02_RS17255	COG2080	2 iron, 2 sulfur cluster binding
HW02_RS17280	COG1944	ATP diphosphatase activity
HW02_RS17300	COG4771	TonB-dependent receptor
HW02_RS17310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW02_RS17310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW02_RS17325	COG0579	oxidoreductase
HW02_RS17360	COG1595	DNA-templated transcription, initiation
HW02_RS17365	COG3712	iron ion homeostasis
HW02_RS17385	COG2814	Major facilitator Superfamily
HW02_RS17435	COG2197	response regulator
HW02_RS17465	COG2366	antibiotic biosynthetic process
HW02_RS17480	COG0625	glutathione transferase activity
HW02_RS17495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS17500	COG0417	DNA replication proofreading
HW02_RS17545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS17615	COG1309	transcriptional regulator
HW02_RS17635	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HW02_RS17640	COG0583	DNA-binding transcription factor activity
HW02_RS17650	COG2354	Protein conserved in bacteria
HW02_RS17655	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS17665	COG2239	Acts as a magnesium transporter
HW02_RS17680	COG2203	Gaf domain
HW02_RS17680	COG3706	GGDEF domain
HW02_RS17680	COG4251	negative regulation of phosphorylation
HW02_RS17680	COG5001	Diguanylate cyclase
HW02_RS17690	COG4977	sequence-specific DNA binding
HW02_RS17695	COG3813	Protein conserved in bacteria
HW02_RS17760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS17785	COG0604	alcohol dehydrogenase
HW02_RS17790	COG0616	signal peptide processing
HW02_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS17820	COG0583	DNA-binding transcription factor activity
HW02_RS17845	COG1024	Enoyl-CoA hydratase
HW02_RS17855	COG0531	amino acid
HW02_RS17870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW02_RS17890	COG0741	lytic transglycosylase activity
HW02_RS17890	COG1388	LysM domain
HW02_RS17895	COG4166	transmembrane transport
HW02_RS17900	COG4166	transmembrane transport
HW02_RS17905	COG4174	ABC transporter (Permease)
HW02_RS17910	COG4239	(ABC) transporter, permease
HW02_RS17915	COG4172	Belongs to the ABC transporter superfamily
HW02_RS17925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS17940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW02_RS17965	COG0745	RESPONSE REGULATOR receiver
HW02_RS17970	COG2205	protein histidine kinase activity
HW02_RS17975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW02_RS18020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW02_RS18040	COG0589	response to stress
HW02_RS18065	COG2201	protein-glutamate methylesterase activity
HW02_RS18075	COG2223	nitrite transmembrane transporter activity
HW02_RS18080	COG0515	serine threonine protein kinase
HW02_RS18085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW02_RS18090	COG2146	nitrite reductase [NAD(P)H] activity
HW02_RS18095	COG0243	molybdopterin cofactor binding
HW02_RS18115	COG0668	transmembrane transport
HW02_RS18155	COG4067	protein conserved in archaea
HW02_RS18155	COG0189	ligase activity
HW02_RS18200	COG2909	trisaccharide binding
HW02_RS18205	COG2909	trisaccharide binding
HW02_RS18240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW02_RS18295	COG0519	Catalyzes the synthesis of GMP from XMP
HW02_RS18310	COG0667	Aldo Keto reductase
HW02_RS18325	COG0183	Belongs to the thiolase family
HW02_RS18345	COG1305	Transglutaminase-like
HW02_RS18355	COG2308	Evidence 4 Homologs of previously reported genes of
HW02_RS18365	COG0505	Belongs to the CarA family
HW02_RS18385	COG1317	bacterial-type flagellum organization
HW02_RS18495	COG4789	Type iii secretion
HW02_RS18545	COG4790	Type iii secretion
HW02_RS18550	COG4794	Type iii secretion
HW02_RS18555	COG4791	protein targeting
HW02_RS18560	COG4792	protein secretion
HW02_RS18640	COG2840	Smr protein MutS2
HW02_RS18660	COG0515	serine threonine protein kinase
HW02_RS18660	COG2815	serine threonine protein kinase
HW02_RS18700	COG2204	response regulator
HW02_RS18750	COG0625	glutathione transferase activity
HW02_RS18755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW02_RS18770	COG3135	benzoate transporter
HW02_RS18780	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS18785	COG2130	NADP-dependent
HW02_RS18810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW02_RS18850	COG0745	RESPONSE REGULATOR receiver
HW02_RS18855	COG2205	protein histidine kinase activity
HW02_RS18880	COG1960	acyl-CoA dehydrogenase activity
HW02_RS18890	COG1024	Enoyl-CoA hydratase
HW02_RS18895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS18900	COG2186	Transcriptional regulator
HW02_RS18905	COG2807	transmembrane transport
HW02_RS18910	COG0628	permease
HW02_RS18920	COG0625	glutathione transferase activity
HW02_RS18950	COG1022	Amp-dependent synthetase and ligase
HW02_RS18980	COG2205	protein histidine kinase activity
HW02_RS18980	COG0784	Response regulator, receiver
HW02_RS18980	COG5002	protein histidine kinase activity
HW02_RS19020	COG1846	Transcriptional regulator
HW02_RS19025	COG2080	2 iron, 2 sulfur cluster binding
HW02_RS19030	COG2010	Cytochrome c
HW02_RS19030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW02_RS19035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW02_RS19035	COG2010	Cytochrome c
HW02_RS19040	COG2207	Transcriptional regulator
HW02_RS19115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW02_RS19120	COG1053	succinate dehydrogenase
HW02_RS19125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HW02_RS19130	COG2009	succinate dehydrogenase
HW02_RS19160	COG3846	protein secretion by the type IV secretion system
HW02_RS19175	COG3451	type IV secretory pathway VirB4
HW02_RS19185	COG3838	Conjugal transfer protein Trbc
HW02_RS19210	COG0583	DNA-binding transcription factor activity
HW02_RS19245	COG0501	Belongs to the peptidase M48B family
HW02_RS19280	COG1192	Involved in chromosome partitioning
HW02_RS19315	COG5489	Protein of unknown function (DUF736)
HW02_RS19330	COG1475	DNA binding
HW02_RS19350	COG2814	Major facilitator Superfamily
HW02_RS19355	COG1937	Protein conserved in bacteria
HW02_RS19365	COG4804	nuclease activity
HW02_RS19395	COG2084	Dehydrogenase
HW02_RS19410	COG3738	Protein conserved in bacteria
HW02_RS19440	COG0251	oxidation-reduction process
HW02_RS19445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS19455	COG0174	glutamine synthetase
HW02_RS19460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS19480	COG0840	transmembrane signaling receptor activity
HW02_RS19495	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS19510	COG2010	Cytochrome c
HW02_RS19515	COG3278	Belongs to the heme-copper respiratory oxidase family
HW02_RS19530	COG2010	Cytochrome c
HW02_RS19540	COG0348	domain, Protein
HW02_RS19550	COG2217	Heavy metal translocating P-type atpase
HW02_RS19590	COG2076	Multidrug Resistance protein
HW02_RS19620	COG1960	acyl-CoA dehydrogenase activity
HW02_RS19635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW02_RS19665	COG1196	nuclear chromosome segregation
HW02_RS19695	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS19700	COG1247	-acetyltransferase
HW02_RS19720	COG1192	Involved in chromosome partitioning
HW02_RS19735	COG0582	viral genome integration into host DNA
HW02_RS19750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW02_RS19760	COG0384	phenazine biosynthesis protein PhzF
HW02_RS19790	COG5006	permease, DMT superfamily
HW02_RS19805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW02_RS19820	COG3795	YCII-related domain
HW02_RS19830	COG2814	Major facilitator Superfamily
HW02_RS19835	COG4941	Belongs to the sigma-70 factor family
HW02_RS19845	COG3795	YCII-related domain
HW02_RS19855	COG2197	response regulator
HW02_RS19860	COG1982	Orn Lys Arg decarboxylase major
HW02_RS19865	COG0189	ligase activity
HW02_RS19870	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS19885	COG0765	amino acid transport
HW02_RS19890	COG0765	amino acid transport
HW02_RS19895	COG1126	abc transporter atp-binding protein
HW02_RS19925	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS19945	COG1253	flavin adenine dinucleotide binding
HW02_RS19950	COG0300	oxidoreductase activity
HW02_RS19960	COG0583	DNA-binding transcription factor activity
HW02_RS19970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW02_RS19975	COG4319	ketosteroid isomerase
HW02_RS19990	COG4774	siderophore transport
HW02_RS20040	COG2814	Major facilitator Superfamily
HW02_RS20060	COG0583	DNA-binding transcription factor activity
HW02_RS20070	COG0121	glutamine amidotransferase
HW02_RS20100	COG3712	iron ion homeostasis
HW02_RS20105	COG1595	DNA-templated transcription, initiation
HW02_RS20120	COG1230	cation diffusion facilitator family transporter
HW02_RS20125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW02_RS20155	COG2252	PERMEase
HW02_RS20215	COG2233	PERMEase
HW02_RS20230	COG1309	transcriptional regulator
HW02_RS20240	COG3960	tartronate-semialdehyde synthase activity
HW02_RS20245	COG3622	Belongs to the hyi family
HW02_RS20250	COG2084	Dehydrogenase
HW02_RS20260	COG0469	pyruvate kinase activity
HW02_RS20265	COG4413	Urea transporter
HW02_RS20270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW02_RS20295	COG3192	ethanolamine utilization protein
HW02_RS20310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS20315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HW02_RS20390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW02_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS20410	COG1496	oxidoreductase activity
HW02_RS20435	COG0835	chemotaxis
HW02_RS20445	COG1192	Involved in chromosome partitioning
HW02_RS20450	COG1360	Flagellar Motor Protein
HW02_RS20455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW02_RS20465	COG2198	Histidine kinase
HW02_RS20465	COG0784	Response regulator, receiver
HW02_RS20465	COG0643	Histidine kinase
HW02_RS20495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW02_RS20500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW02_RS20520	COG1987	bacterial-type flagellum assembly
HW02_RS20560	COG2832	Protein of unknown function (DUF454)
HW02_RS20575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS20580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS20590	COG3300	MHYT domain
HW02_RS20590	COG5001	Diguanylate cyclase
HW02_RS20635	COG0488	(ABC) transporter
HW02_RS20690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS20700	COG0583	DNA-binding transcription factor activity
HW02_RS20715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW02_RS20730	COG1196	nuclear chromosome segregation
HW02_RS20730	COG3264	Mechanosensitive ion channel
HW02_RS20735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW02_RS20735	COG0116	Belongs to the methyltransferase superfamily
HW02_RS20745	COG0210	DNA helicase
HW02_RS20770	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW02_RS20820	COG0438	transferase activity, transferring glycosyl groups
HW02_RS20825	COG0463	Glycosyl transferase, family 2
HW02_RS20830	COG0438	transferase activity, transferring glycosyl groups
HW02_RS20855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW02_RS20865	COG1450	Type ii and iii secretion system protein
HW02_RS20915	COG1960	acyl-CoA dehydrogenase activity
HW02_RS20935	COG0406	alpha-ribazole phosphatase activity
HW02_RS20965	COG0778	Nitroreductase
HW02_RS20980	COG4206	TonB-dependent receptor
HW02_RS20990	COG1802	Transcriptional regulator
HW02_RS21000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS21030	COG0477	Major facilitator Superfamily
HW02_RS21050	COG0765	amino acid transport
HW02_RS21060	COG1126	abc transporter atp-binding protein
HW02_RS21070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW02_RS21075	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS21135	COG0784	Response regulator, receiver
HW02_RS21135	COG4191	Histidine kinase
HW02_RS21175	COG1289	transmembrane transporter activity
HW02_RS21190	COG2207	Transcriptional regulator
HW02_RS21210	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS21215	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS21225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HW02_RS21250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW02_RS21260	COG0318	PFAM AMP-dependent synthetase and ligase
HW02_RS21265	COG0367	asparagine synthase
HW02_RS21275	COG2211	Major facilitator Superfamily
HW02_RS21325	COG1335	isochorismatase
HW02_RS21330	COG0583	DNA-binding transcription factor activity
HW02_RS21340	COG0791	NLP P60 protein
HW02_RS21345	COG0791	NLP P60 protein
HW02_RS21355	COG3829	transcription factor binding
HW02_RS21370	COG2818	Glycosylase
HW02_RS21395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW02_RS21400	COG1960	acyl-CoA dehydrogenase activity
HW02_RS21410	COG0625	glutathione transferase activity
HW02_RS21435	COG3447	MASE1 domain protein
HW02_RS21435	COG5002	protein histidine kinase activity
HW02_RS21435	COG5001	Diguanylate cyclase
HW02_RS21455	COG4459	periplasmic nitrate reductase
HW02_RS21460	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW02_RS21460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW02_RS21465	COG3062	negative regulation of establishment of protein localization
HW02_RS21475	COG3043	anaerobic respiration
HW02_RS21480	COG3005	denitrification pathway
HW02_RS21485	COG2951	lytic endotransglycosylase activity
HW02_RS21490	COG0861	Integral membrane protein TerC family
HW02_RS21495	COG0753	catalase activity
HW02_RS21515	COG2977	Belongs to the P-Pant transferase superfamily
HW02_RS21520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW02_RS21535	COG2226	methyltransferase
HW02_RS21550	COG2205	protein histidine kinase activity
HW02_RS21555	COG0745	RESPONSE REGULATOR receiver
HW02_RS21560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW02_RS21560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW02_RS21565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW02_RS21570	COG1943	Transposase
HW02_RS21600	COG4104	PAAR repeat-containing protein
HW02_RS21615	COG0531	amino acid
HW02_RS21645	COG0583	DNA-binding transcription factor activity
HW02_RS21650	COG3257	ureidoglycine aminohydrolase activity
HW02_RS21665	COG0604	alcohol dehydrogenase
HW02_RS21665	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS21665	COG3321	synthase
HW02_RS21670	COG2197	response regulator
HW02_RS21710	COG0583	DNA-binding transcription factor activity
HW02_RS21715	COG0667	Aldo Keto reductase
HW02_RS21745	COG0242	peptide deformylase activity
HW02_RS21755	COG2199	diguanylate cyclase activity
HW02_RS21760	COG2885	chlorophyll binding
HW02_RS21790	COG1132	(ABC) transporter
HW02_RS21805	COG4628	conserved protein (DUF2132)
HW02_RS21810	COG2133	pyrroloquinoline quinone binding
HW02_RS21825	COG2207	Transcriptional regulator
HW02_RS21830	COG0477	Major facilitator Superfamily
HW02_RS21845	COG2882	bacterial-type flagellum organization
HW02_RS21900	COG1516	flagellar protein fliS
HW02_RS21905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW02_RS21915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW02_RS21920	COG1216	Glycosyl transferase, family 2
HW02_RS21920	COG0438	transferase activity, transferring glycosyl groups
HW02_RS21945	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS21950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW02_RS21995	COG4787	bacterial-type flagellum-dependent cell motility
HW02_RS22005	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW02_RS22015	COG1815	bacterial-type flagellum-dependent cell motility
HW02_RS22065	COG0326	Molecular chaperone. Has ATPase activity
HW02_RS22080	COG3189	MarR family transcriptional regulator
HW02_RS22100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW02_RS22115	COG2212	antiporter activity
HW02_RS22120	COG1863	multisubunit Na H antiporter MnhE subunit
HW02_RS22125	COG0651	ATP synthesis coupled electron transport
HW02_RS22130	COG1006	Multisubunit Na H antiporter MnhC subunit
HW02_RS22135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW02_RS22135	COG2111	Na H antiporter
HW02_RS22140	COG3133	Outer membrane lipoprotein
HW02_RS22150	COG1929	Belongs to the glycerate kinase type-1 family
HW02_RS22155	COG2610	gluconate transmembrane transporter activity
HW02_RS22160	COG3835	regulator
HW02_RS22170	COG2885	chlorophyll binding
HW02_RS22185	COG1199	ATP-dependent helicase activity
HW02_RS22225	COG2860	membrane
HW02_RS22240	COG0653	protein targeting
HW02_RS22245	COG0625	glutathione transferase activity
HW02_RS22270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS22275	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS22300	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS22305	COG1960	acyl-CoA dehydrogenase activity
HW02_RS22310	COG1024	Enoyl-CoA hydratase
HW02_RS22315	COG1960	acyl-CoA dehydrogenase activity
HW02_RS22325	COG2814	Major facilitator Superfamily
HW02_RS22330	COG2030	dehydratase
HW02_RS22340	COG0183	Belongs to the thiolase family
HW02_RS22370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW02_RS22375	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HW02_RS22390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW02_RS22400	COG0425	Belongs to the sulfur carrier protein TusA family
HW02_RS22455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW02_RS22480	COG1051	belongs to the nudix hydrolase family
HW02_RS22495	COG1192	Involved in chromosome partitioning
HW02_RS22610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS22625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS22650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS22755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW02_RS22765	COG1074	ATP-dependent DNA helicase activity
HW02_RS22815	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS22825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW02_RS22830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS22840	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS23035	COG3609	addiction module antidote protein, CC2985 family
HW02_RS23070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HW02_RS23085	COG0602	queuosine metabolic process
HW02_RS23090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HW02_RS23120	COG0824	Thioesterase
HW02_RS23150	COG0783	Belongs to the Dps family
HW02_RS23200	COG3118	belongs to the thioredoxin family
HW02_RS23235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW02_RS23255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW02_RS23305	COG3122	Protein conserved in bacteria
HW02_RS23315	COG3956	TIGRFAM MazG family protein
HW02_RS23320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW02_RS23350	COG5002	protein histidine kinase activity
HW02_RS23350	COG2205	protein histidine kinase activity
HW02_RS23350	COG0784	Response regulator, receiver
HW02_RS23355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW02_RS23405	COG3038	cytochrome b561
HW02_RS23425	COG4807	Protein conserved in bacteria
HW02_RS23435	COG2239	Acts as a magnesium transporter
HW02_RS23505	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HW02_RS23600	COG2301	Belongs to the HpcH HpaI aldolase family
HW02_RS23610	COG2079	MmgE PrpD family protein
HW02_RS23620	COG1960	acyl-CoA dehydrogenase activity
HW02_RS23625	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HW02_RS23630	COG0583	DNA-binding transcription factor activity
HW02_RS23635	COG0583	DNA-binding transcription factor activity
HW02_RS23695	COG1113	amino acid transport
HW02_RS23715	COG3321	synthase
HW02_RS23715	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS23715	COG0604	alcohol dehydrogenase
HW02_RS23745	COG0271	Belongs to the BolA IbaG family
HW02_RS23785	COG0492	ferredoxin-NADP+ reductase activity
HW02_RS23790	COG0450	alkyl hydroperoxide reductase
HW02_RS23825	COG1307	EDD domain protein, DegV family
HW02_RS23835	COG1309	transcriptional regulator
HW02_RS23840	COG0386	Belongs to the glutathione peroxidase family
HW02_RS23865	COG0204	Acyl-transferase
HW02_RS23870	COG2885	chlorophyll binding
HW02_RS23875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW02_RS23890	COG2267	carboxylic ester hydrolase activity
HW02_RS23960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW02_RS23975	COG0546	phosphoglycolate phosphatase activity
HW02_RS23990	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW02_RS24005	COG0656	L-ascorbic acid biosynthetic process
HW02_RS24030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS24040	COG1802	Transcriptional regulator
HW02_RS24050	COG0372	Belongs to the citrate synthase family
HW02_RS24065	COG2079	MmgE PrpD family protein
HW02_RS24080	COG1113	amino acid transport
HW02_RS24110	COG0583	DNA-binding transcription factor activity
HW02_RS24115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW02_RS24125	COG4206	TonB-dependent receptor
HW02_RS24135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW02_RS24200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW02_RS24280	COG3180	Ammonia monooxygenase
HW02_RS24290	COG2720	vancomycin resistance protein
HW02_RS24305	COG1960	acyl-CoA dehydrogenase activity
HW02_RS24310	COG1024	Enoyl-CoA hydratase
HW02_RS24335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW02_RS24405	COG0582	viral genome integration into host DNA
HW02_RS24410	COG0789	Transcriptional regulator
HW02_RS24420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW02_RS24425	COG4644	lycopene metabolic process
HW02_RS24485	COG2003	Belongs to the UPF0758 family
HW02_RS24555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS24575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS24620	COG3621	Patatin-like phospholipase
HW02_RS24740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS24805	COG0583	DNA-binding transcription factor activity
HW02_RS24815	COG0583	DNA-binding transcription factor activity
HW02_RS24820	COG0583	DNA-binding transcription factor activity
HW02_RS24840	COG0071	Belongs to the small heat shock protein (HSP20) family
HW02_RS24845	COG0542	response to heat
HW02_RS24855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW02_RS24860	COG3118	belongs to the thioredoxin family
HW02_RS24875	COG0501	Belongs to the peptidase M48B family
HW02_RS24880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW02_RS24900	COG0789	Transcriptional regulator
HW02_RS24910	COG0583	DNA-binding transcription factor activity
HW02_RS24925	COG4974	Belongs to the 'phage' integrase family
HW02_RS24935	COG4128	Pfam Zonular occludens toxin
HW02_RS25025	COG0583	DNA-binding transcription factor activity
HW02_RS25040	COG0463	Glycosyl transferase, family 2
HW02_RS25045	COG0154	amidase activity
HW02_RS25065	COG0583	DNA-binding transcription factor activity
HW02_RS25075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW02_RS25110	COG2831	hemolysin activation secretion protein
HW02_RS25265	COG0420	3'-5' exonuclease activity
HW02_RS25275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW02_RS25280	COG1074	ATP-dependent DNA helicase activity
HW02_RS25285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HW02_RS25290	COG0095	Lipoate-protein ligase
HW02_RS25295	COG0697	spore germination
HW02_RS25320	COG0306	phosphate transporter
HW02_RS25380	COG4964	Belongs to the GSP D family
HW02_RS25400	COG0433	COG0433 Predicted ATPase
HW02_RS25440	COG0788	formyltetrahydrofolate deformylase activity
HW02_RS25450	COG2925	Exonuclease
HW02_RS25480	COG0714	Associated with various cellular activities
HW02_RS25510	COG0589	response to stress
HW02_RS25520	COG1024	Enoyl-CoA hydratase
HW02_RS25530	COG3706	GGDEF domain
HW02_RS25550	COG0693	protein deglycase activity
HW02_RS25565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW02_RS25580	COG0154	amidase activity
HW02_RS25590	COG1473	amidohydrolase
HW02_RS25605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW02_RS25610	COG0426	domain, Protein
HW02_RS25610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW02_RS25630	COG0589	response to stress
HW02_RS25645	COG2814	Major facilitator Superfamily
HW02_RS25650	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS25665	COG1918	ferrous iron import across plasma membrane
HW02_RS25680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW02_RS25720	COG1704	LemA family
HW02_RS25745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS25750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS25765	COG3642	lipopolysaccharide core region biosynthetic process
HW02_RS25775	COG2205	protein histidine kinase activity
HW02_RS25780	COG0745	RESPONSE REGULATOR receiver
HW02_RS25815	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW02_RS25825	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS25850	COG0668	transmembrane transport
HW02_RS25860	COG0745	RESPONSE REGULATOR receiver
HW02_RS25875	COG2096	Adenosyltransferase
HW02_RS25880	COG0494	nUDIX hydrolase
HW02_RS25905	COG0741	lytic transglycosylase activity
HW02_RS25905	COG0739	heme binding
HW02_RS25905	COG1196	nuclear chromosome segregation
HW02_RS25950	COG0772	Belongs to the SEDS family
HW02_RS25965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW02_RS26005	COG3107	peptidoglycan biosynthetic process
HW02_RS26020	COG2823	Periplasmic or secreted lipoprotein
HW02_RS26025	COG2969	positive regulation of protein catabolic process
HW02_RS26030	COG0625	glutathione transferase activity
HW02_RS26035	COG2857	Cytochrome c1
HW02_RS26040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW02_RS26045	COG0723	plastoquinol--plastocyanin reductase activity
HW02_RS26060	COG0667	Aldo Keto reductase
HW02_RS26065	COG1960	acyl-CoA dehydrogenase activity
HW02_RS26080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW02_RS26090	COG2945	thiolester hydrolase activity
HW02_RS26110	COG2951	lytic endotransglycosylase activity
HW02_RS26120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW02_RS26160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW02_RS26165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW02_RS26170	COG1127	ABC transporter
HW02_RS26180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HW02_RS26195	COG1137	ATPase activity
HW02_RS26250	COG0312	modulator of DNA gyrase
HW02_RS26260	COG0312	modulator of DNA gyrase
HW02_RS26265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW02_RS26275	COG1530	ribonuclease E activity
HW02_RS26290	COG1792	Involved in formation and maintenance of cell shape
HW02_RS26295	COG1077	Cell shape determining protein MreB Mrl
HW02_RS26315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW02_RS26320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW02_RS26325	COG4676	Protein conserved in bacteria
HW02_RS26330	COG5445	Predicted secreted protein (DUF2300)
HW02_RS26345	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HW02_RS26350	COG4676	Protein conserved in bacteria
HW02_RS26355	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HW02_RS26370	COG0747	negative chemotaxis
HW02_RS26375	COG0747	negative chemotaxis
HW02_RS26390	COG0747	negative chemotaxis
HW02_RS26405	COG0747	negative chemotaxis
HW02_RS26410	COG0601	transmembrane transport
HW02_RS26415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW02_RS26420	COG0444	Belongs to the ABC transporter superfamily
HW02_RS26425	COG4608	Belongs to the ABC transporter superfamily
HW02_RS26440	COG1984	allophanate hydrolase subunit 2
HW02_RS26460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW02_RS26465	COG4774	siderophore transport
HW02_RS26480	COG2194	sulfuric ester hydrolase activity
HW02_RS26490	COG0019	diaminopimelate decarboxylase activity
HW02_RS26530	COG4969	Belongs to the N-Me-Phe pilin family
HW02_RS26605	COG1252	NADH dehydrogenase
HW02_RS26610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW02_RS26625	COG1192	Involved in chromosome partitioning
HW02_RS26775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW02_RS26780	COG1278	Cold shock
HW02_RS26790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS26800	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW02_RS26805	COG3657	addiction module killer protein
HW02_RS26830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS26990	COG1074	ATP-dependent DNA helicase activity
HW02_RS27110	COG3609	addiction module antidote protein, CC2985 family
HW02_RS27130	COG3328	transposase activity
HW02_RS27140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HW02_RS27205	COG4969	Belongs to the N-Me-Phe pilin family
HW02_RS27245	COG1047	Peptidyl-prolyl cis-trans
HW02_RS27260	COG0196	riboflavin kinase activity
HW02_RS27275	COG3045	CreA protein
HW02_RS27300	COG0142	geranyltranstransferase activity
HW02_RS27315	COG0545	Peptidyl-prolyl cis-trans isomerase
HW02_RS27335	COG1067	ATP-dependent peptidase activity
HW02_RS27360	COG4650	regulator
HW02_RS27375	COG1690	Belongs to the RtcB family
HW02_RS27380	COG3541	Predicted nucleotidyltransferase
HW02_RS27400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW02_RS27425	COG1136	(ABC) transporter
HW02_RS27425	COG0577	efflux transmembrane transporter activity
HW02_RS27430	COG0577	efflux transmembrane transporter activity
HW02_RS27430	COG1136	(ABC) transporter
HW02_RS27435	COG0488	(ABC) transporter
HW02_RS27455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW02_RS27460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS27515	COG0523	cobalamin synthesis protein
HW02_RS27520	COG2879	small protein
HW02_RS27525	COG1966	Carbon starvation protein
HW02_RS27600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW02_RS27600	COG3608	succinylglutamate desuccinylase aspartoacylase
HW02_RS27605	COG2010	Cytochrome c
HW02_RS27645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW02_RS27655	COG0833	amino acid
HW02_RS27660	COG2119	membrane
HW02_RS27675	COG0501	Belongs to the peptidase M48B family
HW02_RS27680	COG0840	transmembrane signaling receptor activity
HW02_RS27685	COG2135	peptidase activity
HW02_RS27690	COG1285	pathogenesis
HW02_RS27750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW02_RS27805	COG1090	epimerase
HW02_RS27810	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HW02_RS27820	COG0789	Transcriptional regulator
HW02_RS27840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW02_RS27895	COG0012	GTP binding
HW02_RS27900	COG0582	viral genome integration into host DNA
HW02_RS27910	COG1111	helicase
HW02_RS27910	COG1205	dead DEAH box helicase
HW02_RS27915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW02_RS27945	COG4974	Belongs to the 'phage' integrase family
HW02_RS28050	COG3549	Plasmid maintenance system killer
HW02_RS28065	COG0288	reversible hydration of carbon dioxide
HW02_RS28075	COG0456	acetyltransferase
HW02_RS28120	COG1840	ABC-type Fe3 transport system, periplasmic component
HW02_RS28125	COG1178	ABC-type Fe3 transport system permease component
HW02_RS28130	COG3008	intermembrane lipid transfer
HW02_RS28135	COG2995	paraquat-inducible protein a
HW02_RS28140	COG2995	paraquat-inducible protein a
HW02_RS28180	COG1183	phosphatidylcholine synthase activity
HW02_RS28195	COG0028	Belongs to the TPP enzyme family
HW02_RS28205	COG3098	single-species biofilm formation
HW02_RS28215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW02_RS28250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW02_RS28255	COG4558	Periplasmic binding protein
HW02_RS28260	COG3720	iron ion transport
HW02_RS28265	COG4771	TonB-dependent receptor
HW02_RS28290	COG0436	Aminotransferase
HW02_RS28300	COG2321	neutral zinc metallopeptidase
HW02_RS28310	COG2252	PERMEase
HW02_RS28325	COG0436	Aminotransferase
HW02_RS28330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW02_RS28345	COG4191	Histidine kinase
HW02_RS28450	COG0195	Participates in both transcription termination and antitermination
HW02_RS28485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW02_RS28555	COG0497	DNA recombination
HW02_RS28585	COG2186	Transcriptional regulator
HW02_RS28590	COG1620	l-lactate permease
HW02_RS28640	COG0697	spore germination
HW02_RS28660	COG0697	spore germination
HW02_RS28665	COG1522	sequence-specific DNA binding
HW02_RS28675	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS28695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW02_RS28725	COG0509	glycine decarboxylation via glycine cleavage system
HW02_RS28765	COG0531	amino acid
HW02_RS28780	COG3276	selenocysteine insertion sequence binding
HW02_RS28795	COG2864	formate dehydrogenase
HW02_RS28800	COG0437	4 iron, 4 sulfur cluster binding
HW02_RS28810	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HW02_RS28815	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS28815	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS28840	COG0463	Glycosyl transferase, family 2
HW02_RS28850	COG0534	Mate efflux family protein
HW02_RS28860	COG1283	sodium-dependent phosphate transmembrane transporter activity
HW02_RS28885	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HW02_RS28910	COG4221	oxidoreductase activity
HW02_RS28915	COG1272	protein, Hemolysin III
HW02_RS28950	COG0023	Translation Initiation Factor
HW02_RS29040	COG2095	MarC family integral membrane protein
HW02_RS29045	COG0683	leucine binding
HW02_RS29060	COG0411	ABC transporter
HW02_RS29105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW02_RS29120	COG0443	Heat shock 70 kDa protein
HW02_RS29145	COG0789	Transcriptional regulator
HW02_RS29150	COG2982	Protein involved in outer membrane biogenesis
HW02_RS29155	COG2193	ferroxidase activity
HW02_RS29165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW02_RS29170	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HW02_RS29230	COG3712	iron ion homeostasis
HW02_RS29235	COG1595	DNA-templated transcription, initiation
HW02_RS29255	COG2814	Major facilitator Superfamily
HW02_RS29265	COG0583	DNA-binding transcription factor activity
HW02_RS29290	COG4221	oxidoreductase activity
HW02_RS29295	COG2423	ornithine cyclodeaminase activity
HW02_RS29325	COG0583	DNA-binding transcription factor activity
HW02_RS29340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW02_RS29380	COG0668	transmembrane transport
HW02_RS29400	COG3300	MHYT domain
HW02_RS29400	COG5001	Diguanylate cyclase
HW02_RS29410	COG0305	Participates in initiation and elongation during chromosome replication
HW02_RS29440	COG0557	exoribonuclease II activity
HW02_RS29470	COG0330	HflC and HflK could
HW02_RS29475	COG0330	HflC and HflK could
HW02_RS29480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW02_RS29500	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW02_RS29505	COG0802	atpase or kinase
HW02_RS29510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW02_RS29510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW02_RS29565	COG3300	MHYT domain
HW02_RS29565	COG5001	Diguanylate cyclase
HW02_RS29570	COG0560	Phosphoserine phosphatase
HW02_RS29570	COG3830	Belongs to the UPF0237 family
HW02_RS29580	COG1988	membrane-bound metal-dependent
HW02_RS29595	COG3577	Aspartyl protease
HW02_RS29610	COG3150	esterase
HW02_RS29615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HW02_RS29625	COG0494	nUDIX hydrolase
HW02_RS29640	COG1538	Outer membrane efflux protein
HW02_RS29645	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW02_RS29660	COG0045	succinate-CoA ligase (ADP-forming) activity
HW02_RS29665	COG1960	acyl-CoA dehydrogenase activity
HW02_RS29670	COG1024	Enoyl-CoA hydratase
HW02_RS29675	COG0833	amino acid
HW02_RS29705	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS29705	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS29715	COG1519	Transferase
HW02_RS29720	COG0583	DNA-binding transcription factor activity
HW02_RS29735	COG0667	Aldo Keto reductase
HW02_RS29745	COG1960	acyl-CoA dehydrogenase activity
HW02_RS29750	COG1960	acyl-CoA dehydrogenase activity
HW02_RS29760	COG0367	asparagine synthase
HW02_RS29785	COG1215	transferase activity, transferring glycosyl groups
HW02_RS29805	COG0438	transferase activity, transferring glycosyl groups
HW02_RS29810	COG2192	nodulation
HW02_RS29835	COG0438	transferase activity, transferring glycosyl groups
HW02_RS29840	COG0859	PFAM glycosyl transferase family 9
HW02_RS29845	COG0859	PFAM glycosyl transferase family 9
HW02_RS29890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HW02_RS29895	COG1960	acyl-CoA dehydrogenase activity
HW02_RS29910	COG1196	nuclear chromosome segregation
HW02_RS29910	COG3264	Mechanosensitive ion channel
HW02_RS29920	COG0730	response to heat
HW02_RS29925	COG2873	o-acetylhomoserine
HW02_RS29940	COG1192	Involved in chromosome partitioning
HW02_RS29945	COG0583	DNA-binding transcription factor activity
HW02_RS29950	COG2814	Major facilitator Superfamily
HW02_RS29975	COG0493	'glutamate synthase
HW02_RS29980	COG0067	glutamate synthase
HW02_RS29980	COG0069	glutamate synthase activity
HW02_RS29980	COG0070	glutamate synthase
HW02_RS30030	COG0281	malic enzyme
HW02_RS30050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW02_RS30165	COG0840	transmembrane signaling receptor activity
HW02_RS30175	COG1126	abc transporter atp-binding protein
HW02_RS30180	COG0765	amino acid transport
HW02_RS30210	COG1051	belongs to the nudix hydrolase family
HW02_RS30215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW02_RS30220	COG0251	oxidation-reduction process
HW02_RS30265	COG2986	histidine ammonia-lyase
HW02_RS30270	COG4175	Glycine betaine
HW02_RS30275	COG4176	ABC-type proline glycine betaine transport system permease component
HW02_RS30295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW02_RS30330	COG0402	S-adenosylhomocysteine deaminase activity
HW02_RS30380	COG0789	Transcriptional regulator
HW02_RS30385	COG1217	gtp-binding protein TYPA
HW02_RS30410	COG0668	transmembrane transport
HW02_RS30425	COG3852	Histidine kinase
HW02_RS30440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW02_RS30470	COG4942	peptidase
HW02_RS30475	COG0793	Belongs to the peptidase S41A family
HW02_RS30480	COG2861	carbohydrate metabolic process
HW02_RS30540	COG0579	oxidoreductase
HW02_RS30550	COG1194	a g-specific adenine glycosylase
HW02_RS30560	COG0673	inositol 2-dehydrogenase activity
HW02_RS30585	COG0464	growth
HW02_RS30615	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS30660	COG1566	PFAM secretion protein HlyD family protein
HW02_RS30665	COG2814	Major facilitator Superfamily
HW02_RS30675	COG1088	dTDP-glucose 4,6-dehydratase activity
HW02_RS30680	COG1091	dTDP-4-dehydrorhamnose reductase activity
HW02_RS30745	COG1218	3'(2'),5'-bisphosphate nucleotidase
HW02_RS30750	COG0494	nUDIX hydrolase
HW02_RS30755	COG1011	Hydrolase
HW02_RS30760	COG1652	LysM domain
HW02_RS30770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW02_RS30790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW02_RS30800	COG0824	Thioesterase
HW02_RS30805	COG1454	alcohol dehydrogenase
HW02_RS30810	COG1960	acyl-CoA dehydrogenase activity
HW02_RS30815	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS30815	COG1024	Enoyl-CoA hydratase
HW02_RS30825	COG0778	Nitroreductase
HW02_RS30855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW02_RS30860	COG0189	ligase activity
HW02_RS30860	COG4067	protein conserved in archaea
HW02_RS30885	COG2183	response to ionizing radiation
HW02_RS30915	COG0306	phosphate transporter
HW02_RS30920	COG1392	Phosphate transport regulator
HW02_RS30925	COG3025	triphosphatase activity
HW02_RS30930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW02_RS30960	COG1178	ABC-type Fe3 transport system permease component
HW02_RS30970	COG0583	DNA-binding transcription factor activity
HW02_RS30985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW02_RS30995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW02_RS31000	COG0006	proline dipeptidase activity
HW02_RS31025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW02_RS31035	COG0842	Transport permease protein
HW02_RS31040	COG1129	ABC transporter
HW02_RS31040	COG0842	Transport permease protein
HW02_RS31045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW02_RS31060	COG2271	Major facilitator Superfamily
HW02_RS31075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW02_RS31075	COG2755	lipolytic protein G-D-S-L family
HW02_RS31090	COG0248	Ppx GppA phosphatase
HW02_RS31105	COG0586	Pfam SNARE associated Golgi protein
HW02_RS31110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HW02_RS31115	COG2050	protein possibly involved in aromatic compounds catabolism
HW02_RS31125	COG0672	)-iron permease
HW02_RS31130	COG1280	lysine exporter protein (LysE YggA)
HW02_RS31135	COG0861	Integral membrane protein TerC family
HW02_RS31145	COG0488	(ABC) transporter
HW02_RS31200	COG3275	phosphorelay sensor kinase activity
HW02_RS31230	COG0598	Magnesium transport protein CorA
HW02_RS31260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW02_RS31330	COG0432	Pfam Uncharacterised protein family UPF0047
HW02_RS31335	COG0004	ammonium transporteR
HW02_RS31340	COG0347	Belongs to the P(II) protein family
HW02_RS31350	COG0606	chelatase, subunit chli
HW02_RS31355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW02_RS31365	COG0583	DNA-binding transcription factor activity
HW02_RS31380	COG0210	DNA helicase
HW02_RS31385	COG0028	Belongs to the TPP enzyme family
HW02_RS31395	COG0427	acetyl-CoA hydrolase
HW02_RS31405	COG1396	sequence-specific DNA binding
HW02_RS31405	COG1917	Cupin 2, conserved barrel domain protein
HW02_RS31415	COG0251	oxidation-reduction process
HW02_RS31445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS31450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW02_RS31455	COG2814	Major facilitator Superfamily
HW02_RS31460	COG1012	belongs to the aldehyde dehydrogenase family
HW02_RS31465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW02_RS31485	COG0747	negative chemotaxis
HW02_RS31500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW02_RS31540	COG3245	cytochrome
HW02_RS31560	COG0708	Exodeoxyribonuclease III
HW02_RS31575	COG1561	YicC-like family, N-terminal region
HW02_RS31590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW02_RS31610	COG2169	Transcriptional regulator
HW02_RS31620	COG0583	DNA-binding transcription factor activity
HW02_RS31625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW02_RS31665	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HW02_RS31670	COG0247	lactate metabolic process
HW02_RS31675	COG0277	FAD linked oxidase domain protein
HW02_RS31680	COG0277	FAD linked oxidase domain protein
HW02_RS31685	COG2186	Transcriptional regulator
HW02_RS31715	COG1253	flavin adenine dinucleotide binding
HW02_RS31720	COG0739	heme binding
HW02_RS31740	COG0573	inorganic phosphate transmembrane transporter activity
HW02_RS31810	COG4584	PFAM Integrase catalytic
HW02_RS31815	COG1484	DNA-dependent DNA replication
HW02_RS31825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW02_RS31865	COG3474	cytochrome
HW02_RS31980	COG2837	iron assimilation
HW02_RS31990	COG1024	Enoyl-CoA hydratase
HW02_RS31990	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW02_RS32000	COG1051	belongs to the nudix hydrolase family
HW02_RS32050	COG0477	Major facilitator Superfamily
HW02_RS32055	COG1607	acyl-coa hydrolase
HW02_RS32080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW02_RS32085	COG4175	Glycine betaine
HW02_RS32090	COG4176	ABC-type proline glycine betaine transport system permease component
HW02_RS32100	COG1760	l-serine dehydratase
HW02_RS32115	COG0583	DNA-binding transcription factor activity
HW02_RS32125	COG0657	acetylesterase activity
HW02_RS32140	COG3246	L-lysine catabolic process to acetate
HW02_RS32195	COG1902	pentaerythritol trinitrate reductase activity
HW02_RS32195	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW02_RS32200	COG2181	nitrate reductase activity
HW02_RS32200	COG0247	lactate metabolic process
HW02_RS32220	COG3655	Transcriptional regulator
HW02_RS32260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW02_RS32260	COG1017	nitric oxide dioxygenase activity
HW02_RS32350	COG0583	DNA-binding transcription factor activity
HW02_RS32365	COG2391	methyltransferase activity
HW02_RS32390	COG0511	ligase activity, forming carbon-carbon bonds
HW02_RS32390	COG5016	pyruvate
HW02_RS32395	COG0439	Biotin carboxylase
HW02_RS32400	COG0583	DNA-binding transcription factor activity
HW02_RS32415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW02_RS32420	COG0826	peptidase U32
HW02_RS32440	COG0210	DNA helicase
HW02_RS32450	COG0427	acetyl-CoA hydrolase
HW02_RS32465	COG0438	transferase activity, transferring glycosyl groups
HW02_RS32510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW02_RS32515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW02_RS32515	COG2755	lipolytic protein G-D-S-L family
HW02_RS32555	COG0679	Auxin Efflux Carrier
HW02_RS32565	COG2851	Citrate transporter
HW02_RS32570	COG0861	Integral membrane protein TerC family
HW02_RS32575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW02_RS32580	COG1690	Belongs to the RtcB family
HW02_RS32625	COG0700	Nucleoside recognition
HW02_RS32630	COG1301	dicarboxylic acid transport
HW02_RS32655	COG5002	protein histidine kinase activity
HW02_RS32660	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW02_RS32665	COG2095	MarC family integral membrane protein
HW02_RS32690	COG3245	cytochrome
HW02_RS32725	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HW02_RS32730	COG0735	belongs to the Fur family
HW02_RS32740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW02_RS32755	COG2011	ABC-type metal ion transport system permease component
HW02_RS32785	COG0531	amino acid
HW02_RS32795	COG4191	Histidine kinase
HW02_RS32830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW02_RS32830	COG4651	solute:proton antiporter activity
HW02_RS32835	COG1607	acyl-coa hydrolase
HW02_RS32845	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS32850	COG0174	glutamine synthetase
HW02_RS32855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW02_RS32860	COG1028	Short-chain dehydrogenase reductase Sdr
HW02_RS32885	COG4651	solute:proton antiporter activity
HW02_RS32885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW02_RS32890	COG0477	Major facilitator Superfamily
HW02_RS32900	COG0523	cobalamin synthesis protein
HW02_RS32945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW02_RS32965	COG2358	TRAP transporter, solute receptor (TAXI family
HW02_RS32970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW02_RS32990	COG1349	DNA-binding transcription factor activity
HW02_RS33050	COG1475	DNA binding
HW02_RS33055	COG1192	Involved in chromosome partitioning