locus-tag	class	description
D8668_RS00060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D8668_RS00090	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS00095	COG1113	amino acid transport
D8668_RS00110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8668_RS00115	COG0235	Class ii aldolase
D8668_RS00120	COG1396	sequence-specific DNA binding
D8668_RS00125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D8668_RS00130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8668_RS00140	COG0477	Major facilitator Superfamily
D8668_RS00150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8668_RS00155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8668_RS00160	COG0583	DNA-binding transcription factor activity
D8668_RS00180	COG0673	inositol 2-dehydrogenase activity
D8668_RS00200	COG2271	Major facilitator Superfamily
D8668_RS00210	COG1309	transcriptional regulator
D8668_RS00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D8668_RS00225	COG0477	Major facilitator Superfamily
D8668_RS00245	COG2239	Acts as a magnesium transporter
D8668_RS00365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D8668_RS00370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D8668_RS00385	COG0789	Transcriptional regulator
D8668_RS00395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D8668_RS00405	COG0714	Associated with various cellular activities
D8668_RS00520	COG3344	reverse transcriptase
D8668_RS00555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8668_RS00570	COG2226	methyltransferase
D8668_RS00645	COG3012	SEC-C Motif Domain Protein
D8668_RS00680	COG0732	type I restriction modification DNA specificity domain
D8668_RS00705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D8668_RS00750	COG0347	Belongs to the P(II) protein family
D8668_RS00755	COG0004	ammonium transporteR
D8668_RS00760	COG0432	Pfam Uncharacterised protein family UPF0047
D8668_RS00830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D8668_RS00860	COG0598	Magnesium transport protein CorA
D8668_RS00890	COG3275	phosphorelay sensor kinase activity
D8668_RS00945	COG0488	(ABC) transporter
D8668_RS00955	COG0861	Integral membrane protein TerC family
D8668_RS00960	COG1280	lysine exporter protein (LysE YggA)
D8668_RS00965	COG0672	)-iron permease
D8668_RS00975	COG2050	protein possibly involved in aromatic compounds catabolism
D8668_RS00980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D8668_RS00985	COG0586	Pfam SNARE associated Golgi protein
D8668_RS01000	COG0248	Ppx GppA phosphatase
D8668_RS01015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D8668_RS01015	COG2755	lipolytic protein G-D-S-L family
D8668_RS01030	COG2271	Major facilitator Superfamily
D8668_RS01045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS01050	COG0842	Transport permease protein
D8668_RS01050	COG1129	ABC transporter
D8668_RS01055	COG0842	Transport permease protein
D8668_RS01065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D8668_RS01090	COG0006	proline dipeptidase activity
D8668_RS01095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8668_RS01105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8668_RS01120	COG0583	DNA-binding transcription factor activity
D8668_RS01130	COG1178	ABC-type Fe3 transport system permease component
D8668_RS01160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D8668_RS01165	COG3025	triphosphatase activity
D8668_RS01170	COG1392	Phosphate transport regulator
D8668_RS01175	COG0306	phosphate transporter
D8668_RS01205	COG2183	response to ionizing radiation
D8668_RS01230	COG0189	ligase activity
D8668_RS01230	COG4067	protein conserved in archaea
D8668_RS01235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D8668_RS01265	COG0778	Nitroreductase
D8668_RS01275	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8668_RS01275	COG1024	Enoyl-CoA hydratase
D8668_RS01280	COG1960	acyl-CoA dehydrogenase activity
D8668_RS01285	COG1454	alcohol dehydrogenase
D8668_RS01290	COG0824	Thioesterase
D8668_RS01300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D8668_RS01320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D8668_RS01330	COG1652	LysM domain
D8668_RS01335	COG1011	Hydrolase
D8668_RS01340	COG0494	nUDIX hydrolase
D8668_RS01410	COG1091	dTDP-4-dehydrorhamnose reductase activity
D8668_RS01415	COG1088	dTDP-glucose 4,6-dehydratase activity
D8668_RS01450	COG2814	Major facilitator Superfamily
D8668_RS01455	COG1566	PFAM secretion protein HlyD family protein
D8668_RS01465	COG1846	Transcriptional regulator
D8668_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS01530	COG4974	Belongs to the 'phage' integrase family
D8668_RS01585	COG0673	inositol 2-dehydrogenase activity
D8668_RS01595	COG1194	a g-specific adenine glycosylase
D8668_RS01605	COG0579	oxidoreductase
D8668_RS01665	COG2861	carbohydrate metabolic process
D8668_RS01670	COG0793	Belongs to the peptidase S41A family
D8668_RS01675	COG4942	peptidase
D8668_RS01705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D8668_RS01725	COG3852	Histidine kinase
D8668_RS01740	COG0668	transmembrane transport
D8668_RS01765	COG1217	gtp-binding protein TYPA
D8668_RS01820	COG0402	S-adenosylhomocysteine deaminase activity
D8668_RS01855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D8668_RS01875	COG4176	ABC-type proline glycine betaine transport system permease component
D8668_RS01880	COG4175	Glycine betaine
D8668_RS01885	COG2986	histidine ammonia-lyase
D8668_RS01910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8668_RS01940	COG0251	oxidation-reduction process
D8668_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS01950	COG1051	belongs to the nudix hydrolase family
D8668_RS01980	COG0765	amino acid transport
D8668_RS01985	COG1126	abc transporter atp-binding protein
D8668_RS01995	COG0840	transmembrane signaling receptor activity
D8668_RS02115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8668_RS02135	COG0281	malic enzyme
D8668_RS02185	COG0067	glutamate synthase
D8668_RS02185	COG0070	glutamate synthase
D8668_RS02185	COG0069	glutamate synthase activity
D8668_RS02190	COG0493	'glutamate synthase
D8668_RS02215	COG2814	Major facilitator Superfamily
D8668_RS02220	COG0583	DNA-binding transcription factor activity
D8668_RS02225	COG1192	Involved in chromosome partitioning
D8668_RS02240	COG2873	o-acetylhomoserine
D8668_RS02245	COG0730	response to heat
D8668_RS02255	COG3264	Mechanosensitive ion channel
D8668_RS02255	COG1196	nuclear chromosome segregation
D8668_RS02270	COG1960	acyl-CoA dehydrogenase activity
D8668_RS02275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D8668_RS02315	COG0859	PFAM glycosyl transferase family 9
D8668_RS02320	COG0859	PFAM glycosyl transferase family 9
D8668_RS02325	COG0438	transferase activity, transferring glycosyl groups
D8668_RS02350	COG2192	nodulation
D8668_RS02355	COG0438	transferase activity, transferring glycosyl groups
D8668_RS02375	COG1215	transferase activity, transferring glycosyl groups
D8668_RS02400	COG1960	acyl-CoA dehydrogenase activity
D8668_RS02405	COG1960	acyl-CoA dehydrogenase activity
D8668_RS02415	COG0667	Aldo Keto reductase
D8668_RS02430	COG0583	DNA-binding transcription factor activity
D8668_RS02435	COG1519	Transferase
D8668_RS02445	COG1902	pentaerythritol trinitrate reductase activity
D8668_RS02445	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8668_RS02475	COG0833	amino acid
D8668_RS02480	COG1024	Enoyl-CoA hydratase
D8668_RS02485	COG1960	acyl-CoA dehydrogenase activity
D8668_RS02505	COG2249	NAD(P)H dehydrogenase (quinone) activity
D8668_RS02510	COG1538	Outer membrane efflux protein
D8668_RS02525	COG0494	nUDIX hydrolase
D8668_RS02535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8668_RS02540	COG3150	esterase
D8668_RS02555	COG3577	Aspartyl protease
D8668_RS02570	COG1988	membrane-bound metal-dependent
D8668_RS02580	COG0560	Phosphoserine phosphatase
D8668_RS02580	COG3830	Belongs to the UPF0237 family
D8668_RS02585	COG3300	MHYT domain
D8668_RS02585	COG5001	Diguanylate cyclase
D8668_RS02640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D8668_RS02640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D8668_RS02645	COG0802	atpase or kinase
D8668_RS02650	COG0860	N-Acetylmuramoyl-L-alanine amidase
D8668_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8668_RS02675	COG0330	HflC and HflK could
D8668_RS02680	COG0330	HflC and HflK could
D8668_RS02710	COG0557	exoribonuclease II activity
D8668_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
D8668_RS02755	COG5001	Diguanylate cyclase
D8668_RS02755	COG3300	MHYT domain
D8668_RS02780	COG0668	transmembrane transport
D8668_RS02820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D8668_RS02835	COG0583	DNA-binding transcription factor activity
D8668_RS02865	COG2423	ornithine cyclodeaminase activity
D8668_RS02870	COG4221	oxidoreductase activity
D8668_RS02895	COG0583	DNA-binding transcription factor activity
D8668_RS02905	COG2814	Major facilitator Superfamily
D8668_RS02925	COG1595	DNA-templated transcription, initiation
D8668_RS02990	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D8668_RS02995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D8668_RS03005	COG2193	ferroxidase activity
D8668_RS03010	COG2982	Protein involved in outer membrane biogenesis
D8668_RS03015	COG0789	Transcriptional regulator
D8668_RS03040	COG0443	Heat shock 70 kDa protein
D8668_RS03060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D8668_RS03105	COG0411	ABC transporter
D8668_RS03120	COG0683	leucine binding
D8668_RS03125	COG2095	MarC family integral membrane protein
D8668_RS03215	COG0023	Translation Initiation Factor
D8668_RS03250	COG1272	protein, Hemolysin III
D8668_RS03255	COG4221	oxidoreductase activity
D8668_RS03280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D8668_RS03305	COG1283	sodium-dependent phosphate transmembrane transporter activity
D8668_RS03315	COG0534	Mate efflux family protein
D8668_RS03325	COG0463	Glycosyl transferase, family 2
D8668_RS03350	COG1902	pentaerythritol trinitrate reductase activity
D8668_RS03350	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8668_RS03355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D8668_RS03360	COG3383	formate dehydrogenase (NAD+) activity
D8668_RS03360	COG0243	molybdopterin cofactor binding
D8668_RS03365	COG0243	molybdopterin cofactor binding
D8668_RS03365	COG3383	formate dehydrogenase (NAD+) activity
D8668_RS03370	COG0437	4 iron, 4 sulfur cluster binding
D8668_RS03375	COG2864	formate dehydrogenase
D8668_RS03390	COG3276	selenocysteine insertion sequence binding
D8668_RS03405	COG0531	amino acid
D8668_RS03445	COG0509	glycine decarboxylation via glycine cleavage system
D8668_RS03475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8668_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS03505	COG1522	sequence-specific DNA binding
D8668_RS03510	COG0697	spore germination
D8668_RS03530	COG0697	spore germination
D8668_RS03580	COG1620	l-lactate permease
D8668_RS03585	COG2186	Transcriptional regulator
D8668_RS03615	COG0497	DNA recombination
D8668_RS03685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D8668_RS03720	COG0195	Participates in both transcription termination and antitermination
D8668_RS03825	COG4191	Histidine kinase
D8668_RS03840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D8668_RS03845	COG0436	Aminotransferase
D8668_RS03860	COG2252	PERMEase
D8668_RS03870	COG2321	neutral zinc metallopeptidase
D8668_RS03880	COG0436	Aminotransferase
D8668_RS03905	COG4771	TonB-dependent receptor
D8668_RS03910	COG3720	iron ion transport
D8668_RS03915	COG4558	Periplasmic binding protein
D8668_RS03920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8668_RS03955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8668_RS03965	COG3098	single-species biofilm formation
D8668_RS03975	COG0028	Belongs to the TPP enzyme family
D8668_RS03990	COG1183	phosphatidylcholine synthase activity
D8668_RS04030	COG2995	paraquat-inducible protein a
D8668_RS04035	COG2995	paraquat-inducible protein a
D8668_RS04040	COG3008	intermembrane lipid transfer
D8668_RS04045	COG1178	ABC-type Fe3 transport system permease component
D8668_RS04050	COG1840	ABC-type Fe3 transport system, periplasmic component
D8668_RS04095	COG0456	acetyltransferase
D8668_RS04105	COG0288	reversible hydration of carbon dioxide
D8668_RS04120	COG3549	Plasmid maintenance system killer
D8668_RS04135	COG0012	GTP binding
D8668_RS04190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D8668_RS04210	COG0789	Transcriptional regulator
D8668_RS04220	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
D8668_RS04225	COG1090	epimerase
D8668_RS04280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D8668_RS04340	COG1285	pathogenesis
D8668_RS04345	COG2135	peptidase activity
D8668_RS04350	COG0840	transmembrane signaling receptor activity
D8668_RS04355	COG0501	Belongs to the peptidase M48B family
D8668_RS04370	COG2119	membrane
D8668_RS04375	COG0833	amino acid
D8668_RS04385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D8668_RS04425	COG2010	Cytochrome c
D8668_RS04430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D8668_RS04430	COG3608	succinylglutamate desuccinylase aspartoacylase
D8668_RS04500	COG1966	Carbon starvation protein
D8668_RS04505	COG2879	small protein
D8668_RS04510	COG0523	cobalamin synthesis protein
D8668_RS04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS04540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS04560	COG0488	(ABC) transporter
D8668_RS04565	COG1136	(ABC) transporter
D8668_RS04565	COG0577	efflux transmembrane transporter activity
D8668_RS04570	COG1136	(ABC) transporter
D8668_RS04570	COG0577	efflux transmembrane transporter activity
D8668_RS04595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8668_RS04615	COG3541	Predicted nucleotidyltransferase
D8668_RS04620	COG1690	Belongs to the RtcB family
D8668_RS04635	COG4650	regulator
D8668_RS04660	COG1067	ATP-dependent peptidase activity
D8668_RS04680	COG0545	Peptidyl-prolyl cis-trans isomerase
D8668_RS04695	COG0142	geranyltranstransferase activity
D8668_RS04720	COG3045	CreA protein
D8668_RS04735	COG0196	riboflavin kinase activity
D8668_RS04750	COG1047	Peptidyl-prolyl cis-trans
D8668_RS04855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D8668_RS04865	COG3328	transposase activity
D8668_RS04880	COG3668	Plasmid stabilization system
D8668_RS04885	COG3609	addiction module antidote protein, CC2985 family
D8668_RS04995	COG1074	ATP-dependent DNA helicase activity
D8668_RS05160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D8668_RS05185	COG3657	addiction module killer protein
D8668_RS05190	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D8668_RS05200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D8668_RS05215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D8668_RS05375	COG1192	Involved in chromosome partitioning
D8668_RS05385	COG2831	hemolysin activation secretion protein
D8668_RS05390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D8668_RS05395	COG1252	NADH dehydrogenase
D8668_RS05460	COG4969	Belongs to the N-Me-Phe pilin family
D8668_RS05500	COG0019	diaminopimelate decarboxylase activity
D8668_RS05510	COG2194	sulfuric ester hydrolase activity
D8668_RS05525	COG4774	siderophore transport
D8668_RS05550	COG1984	allophanate hydrolase subunit 2
D8668_RS05565	COG4608	Belongs to the ABC transporter superfamily
D8668_RS05570	COG0444	Belongs to the ABC transporter superfamily
D8668_RS05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8668_RS05580	COG0601	transmembrane transport
D8668_RS05585	COG0747	negative chemotaxis
D8668_RS05600	COG0747	negative chemotaxis
D8668_RS05615	COG0747	negative chemotaxis
D8668_RS05620	COG0747	negative chemotaxis
D8668_RS05635	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D8668_RS05640	COG4676	Protein conserved in bacteria
D8668_RS05645	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
D8668_RS05660	COG5445	Predicted secreted protein (DUF2300)
D8668_RS05665	COG4676	Protein conserved in bacteria
D8668_RS05670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8668_RS05675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D8668_RS05695	COG1077	Cell shape determining protein MreB Mrl
D8668_RS05715	COG1530	ribonuclease E activity
D8668_RS05725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D8668_RS05730	COG0312	modulator of DNA gyrase
D8668_RS05740	COG0312	modulator of DNA gyrase
D8668_RS05795	COG1137	ATPase activity
D8668_RS05810	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D8668_RS05820	COG1127	ABC transporter
D8668_RS05825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8668_RS05830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D8668_RS05870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8668_RS05880	COG2951	lytic endotransglycosylase activity
D8668_RS05900	COG2945	thiolester hydrolase activity
D8668_RS05910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D8668_RS05925	COG1960	acyl-CoA dehydrogenase activity
D8668_RS05930	COG0667	Aldo Keto reductase
D8668_RS05945	COG0723	plastoquinol--plastocyanin reductase activity
D8668_RS05950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D8668_RS05955	COG2857	Cytochrome c1
D8668_RS05960	COG0625	glutathione transferase activity
D8668_RS05965	COG2969	positive regulation of protein catabolic process
D8668_RS05970	COG2823	Periplasmic or secreted lipoprotein
D8668_RS05985	COG3107	peptidoglycan biosynthetic process
D8668_RS06025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8668_RS06040	COG0772	Belongs to the SEDS family
D8668_RS06085	COG0739	heme binding
D8668_RS06085	COG0741	lytic transglycosylase activity
D8668_RS06085	COG1196	nuclear chromosome segregation
D8668_RS06110	COG0494	nUDIX hydrolase
D8668_RS06115	COG2096	Adenosyltransferase
D8668_RS06130	COG0745	RESPONSE REGULATOR receiver
D8668_RS06140	COG0668	transmembrane transport
D8668_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS06175	COG3030	protein affecting phage T7 exclusion by the F plasmid
D8668_RS06210	COG0745	RESPONSE REGULATOR receiver
D8668_RS06215	COG2205	protein histidine kinase activity
D8668_RS06225	COG3642	lipopolysaccharide core region biosynthetic process
D8668_RS06240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS06245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS06270	COG1704	LemA family
D8668_RS06310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8668_RS06325	COG1918	ferrous iron import across plasma membrane
D8668_RS06340	COG1902	pentaerythritol trinitrate reductase activity
D8668_RS06360	COG0589	response to stress
D8668_RS06380	COG0426	domain, Protein
D8668_RS06380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8668_RS06385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D8668_RS06400	COG1473	amidohydrolase
D8668_RS06410	COG0154	amidase activity
D8668_RS06425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8668_RS06440	COG0693	protein deglycase activity
D8668_RS06460	COG3706	GGDEF domain
D8668_RS06470	COG1024	Enoyl-CoA hydratase
D8668_RS06480	COG0589	response to stress
D8668_RS06510	COG0714	Associated with various cellular activities
D8668_RS06540	COG2925	Exonuclease
D8668_RS06550	COG0788	formyltetrahydrofolate deformylase activity
D8668_RS06590	COG0433	COG0433 Predicted ATPase
D8668_RS06610	COG4964	Belongs to the GSP D family
D8668_RS06670	COG0306	phosphate transporter
D8668_RS06680	COG0840	transmembrane signaling receptor activity
D8668_RS06695	COG0697	spore germination
D8668_RS06700	COG0095	Lipoate-protein ligase
D8668_RS06705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D8668_RS06710	COG1074	ATP-dependent DNA helicase activity
D8668_RS06715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D8668_RS06725	COG0420	3'-5' exonuclease activity
D8668_RS06865	COG2831	hemolysin activation secretion protein
D8668_RS06900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8668_RS06910	COG0583	DNA-binding transcription factor activity
D8668_RS06930	COG0154	amidase activity
D8668_RS06940	COG0463	Glycosyl transferase, family 2
D8668_RS06955	COG0583	DNA-binding transcription factor activity
D8668_RS07040	COG4128	Pfam Zonular occludens toxin
D8668_RS07050	COG4974	Belongs to the 'phage' integrase family
D8668_RS07130	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D8668_RS07135	COG2910	NAD(P)H-binding
D8668_RS07155	COG1024	Enoyl-CoA hydratase
D8668_RS07160	COG1960	acyl-CoA dehydrogenase activity
D8668_RS07175	COG2720	vancomycin resistance protein
D8668_RS07185	COG3180	Ammonia monooxygenase
D8668_RS07265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8668_RS07330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D8668_RS07340	COG4206	TonB-dependent receptor
D8668_RS07350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8668_RS07355	COG0583	DNA-binding transcription factor activity
D8668_RS07385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8668_RS07390	COG1113	amino acid transport
D8668_RS07405	COG2079	MmgE PrpD family protein
D8668_RS07420	COG0372	Belongs to the citrate synthase family
D8668_RS07430	COG1802	Transcriptional regulator
D8668_RS07440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D8668_RS07465	COG0656	L-ascorbic acid biosynthetic process
D8668_RS07480	COG3023	N-Acetylmuramoyl-L-alanine amidase
D8668_RS07495	COG0546	phosphoglycolate phosphatase activity
D8668_RS07510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8668_RS07595	COG2267	carboxylic ester hydrolase activity
D8668_RS07610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8668_RS07615	COG2885	chlorophyll binding
D8668_RS07620	COG0204	Acyl-transferase
D8668_RS07645	COG0386	Belongs to the glutathione peroxidase family
D8668_RS07650	COG1309	transcriptional regulator
D8668_RS07660	COG1307	EDD domain protein, DegV family
D8668_RS07690	COG5002	protein histidine kinase activity
D8668_RS07690	COG3447	MASE1 domain protein
D8668_RS07690	COG5001	Diguanylate cyclase
D8668_RS07695	COG0450	alkyl hydroperoxide reductase
D8668_RS07700	COG0492	ferredoxin-NADP+ reductase activity
D8668_RS07740	COG0271	Belongs to the BolA IbaG family
D8668_RS07760	COG5002	protein histidine kinase activity
D8668_RS07760	COG5001	Diguanylate cyclase
D8668_RS07790	COG1113	amino acid transport
D8668_RS07850	COG0583	DNA-binding transcription factor activity
D8668_RS07855	COG0583	DNA-binding transcription factor activity
D8668_RS07860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D8668_RS07865	COG1960	acyl-CoA dehydrogenase activity
D8668_RS07875	COG2079	MmgE PrpD family protein
D8668_RS07885	COG2301	Belongs to the HpcH HpaI aldolase family
D8668_RS07980	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D8668_RS08050	COG2239	Acts as a magnesium transporter
D8668_RS08060	COG4807	Protein conserved in bacteria
D8668_RS08080	COG3038	cytochrome b561
D8668_RS08130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D8668_RS08135	COG0784	Response regulator, receiver
D8668_RS08135	COG5002	protein histidine kinase activity
D8668_RS08135	COG2205	protein histidine kinase activity
D8668_RS08165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8668_RS08170	COG3956	TIGRFAM MazG family protein
D8668_RS08180	COG3122	Protein conserved in bacteria
D8668_RS08220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D8668_RS08240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D8668_RS08275	COG3118	belongs to the thioredoxin family
D8668_RS08320	COG0783	Belongs to the Dps family
D8668_RS08350	COG0824	Thioesterase
D8668_RS08380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D8668_RS08385	COG0602	queuosine metabolic process
D8668_RS08405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D8668_RS08415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8668_RS08425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8668_RS08430	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D8668_RS08440	COG0235	Class ii aldolase
D8668_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS08465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8668_RS08465	COG0475	glutathione-regulated potassium exporter activity
D8668_RS08555	COG3188	usher protein
D8668_RS08560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8668_RS08615	COG0425	Belongs to the sulfur carrier protein TusA family
D8668_RS08625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D8668_RS08640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D8668_RS08645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D8668_RS08675	COG0183	Belongs to the thiolase family
D8668_RS08685	COG2030	dehydratase
D8668_RS08690	COG2814	Major facilitator Superfamily
D8668_RS08700	COG1960	acyl-CoA dehydrogenase activity
D8668_RS08705	COG1024	Enoyl-CoA hydratase
D8668_RS08710	COG1960	acyl-CoA dehydrogenase activity
D8668_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS08740	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS08745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS08770	COG0625	glutathione transferase activity
D8668_RS08775	COG0653	protein targeting
D8668_RS08790	COG2860	membrane
D8668_RS08830	COG1199	ATP-dependent helicase activity
D8668_RS08845	COG2885	chlorophyll binding
D8668_RS08855	COG3835	regulator
D8668_RS08860	COG2610	gluconate transmembrane transporter activity
D8668_RS08875	COG3133	Outer membrane lipoprotein
D8668_RS08885	COG2111	Na H antiporter
D8668_RS08885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8668_RS08890	COG1006	Multisubunit Na H antiporter MnhC subunit
D8668_RS08895	COG0651	ATP synthesis coupled electron transport
D8668_RS08900	COG1863	multisubunit Na H antiporter MnhE subunit
D8668_RS08905	COG2212	antiporter activity
D8668_RS08920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D8668_RS08940	COG3189	MarR family transcriptional regulator
D8668_RS08955	COG0326	Molecular chaperone. Has ATPase activity
D8668_RS09005	COG1815	bacterial-type flagellum-dependent cell motility
D8668_RS09015	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D8668_RS09025	COG4787	bacterial-type flagellum-dependent cell motility
D8668_RS09070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8668_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS09100	COG0438	transferase activity, transferring glycosyl groups
D8668_RS09100	COG1216	Glycosyl transferase, family 2
D8668_RS09105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D8668_RS09115	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D8668_RS09120	COG1516	flagellar protein fliS
D8668_RS09175	COG2882	bacterial-type flagellum organization
D8668_RS09190	COG0477	Major facilitator Superfamily
D8668_RS09195	COG2207	Transcriptional regulator
D8668_RS09210	COG2133	pyrroloquinoline quinone binding
D8668_RS09215	COG4628	conserved protein (DUF2132)
D8668_RS09230	COG1132	(ABC) transporter
D8668_RS09260	COG2885	chlorophyll binding
D8668_RS09265	COG2199	diguanylate cyclase activity
D8668_RS09275	COG0242	peptide deformylase activity
D8668_RS09305	COG0667	Aldo Keto reductase
D8668_RS09310	COG0583	DNA-binding transcription factor activity
D8668_RS09350	COG2197	response regulator
D8668_RS09355	COG3321	synthase
D8668_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS09355	COG0604	alcohol dehydrogenase
D8668_RS09370	COG3257	ureidoglycine aminohydrolase activity
D8668_RS09375	COG0583	DNA-binding transcription factor activity
D8668_RS09405	COG0531	amino acid
D8668_RS09440	COG1943	Transposase
D8668_RS09445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8668_RS09450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D8668_RS09450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8668_RS09455	COG0745	RESPONSE REGULATOR receiver
D8668_RS09460	COG2205	protein histidine kinase activity
D8668_RS09490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8668_RS09515	COG0753	catalase activity
D8668_RS09520	COG0861	Integral membrane protein TerC family
D8668_RS09525	COG2951	lytic endotransglycosylase activity
D8668_RS09530	COG3005	denitrification pathway
D8668_RS09535	COG3043	anaerobic respiration
D8668_RS09545	COG3062	negative regulation of establishment of protein localization
D8668_RS09550	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8668_RS09550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8668_RS09555	COG4459	periplasmic nitrate reductase
D8668_RS09575	COG5001	Diguanylate cyclase
D8668_RS09575	COG5002	protein histidine kinase activity
D8668_RS09575	COG3447	MASE1 domain protein
D8668_RS09600	COG0625	glutathione transferase activity
D8668_RS09610	COG1960	acyl-CoA dehydrogenase activity
D8668_RS09615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8668_RS09640	COG2818	Glycosylase
D8668_RS09655	COG3829	transcription factor binding
D8668_RS09665	COG0791	NLP P60 protein
D8668_RS09670	COG0791	NLP P60 protein
D8668_RS09680	COG0583	DNA-binding transcription factor activity
D8668_RS09685	COG1335	isochorismatase
D8668_RS09735	COG2211	Major facilitator Superfamily
D8668_RS09745	COG0367	asparagine synthase
D8668_RS09750	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS09760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8668_RS09785	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D8668_RS09795	COG0583	DNA-binding transcription factor activity
D8668_RS09800	COG2957	Belongs to the agmatine deiminase family
D8668_RS09815	COG2957	Belongs to the agmatine deiminase family
D8668_RS09820	COG2249	NAD(P)H dehydrogenase (quinone) activity
D8668_RS09840	COG2207	Transcriptional regulator
D8668_RS09855	COG1289	transmembrane transporter activity
D8668_RS09910	COG4191	Histidine kinase
D8668_RS09910	COG0784	Response regulator, receiver
D8668_RS09970	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS09975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8668_RS09985	COG1126	abc transporter atp-binding protein
D8668_RS09995	COG0765	amino acid transport
D8668_RS10015	COG0477	Major facilitator Superfamily
D8668_RS10050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS10060	COG1802	Transcriptional regulator
D8668_RS10070	COG4206	TonB-dependent receptor
D8668_RS10085	COG0778	Nitroreductase
D8668_RS10115	COG0406	alpha-ribazole phosphatase activity
D8668_RS10135	COG1960	acyl-CoA dehydrogenase activity
D8668_RS10195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8668_RS10200	COG1230	cation diffusion facilitator family transporter
D8668_RS10215	COG1595	DNA-templated transcription, initiation
D8668_RS10220	COG3712	iron ion homeostasis
D8668_RS10250	COG0121	glutamine amidotransferase
D8668_RS10260	COG0583	DNA-binding transcription factor activity
D8668_RS10330	COG4774	siderophore transport
D8668_RS10345	COG4319	ketosteroid isomerase
D8668_RS10350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8668_RS10355	COG1864	DNA RNA non-specific endonuclease
D8668_RS10355	COG3591	Belongs to the peptidase S1B family
D8668_RS10360	COG0583	DNA-binding transcription factor activity
D8668_RS10370	COG0300	oxidoreductase activity
D8668_RS10375	COG1253	flavin adenine dinucleotide binding
D8668_RS10420	COG1126	abc transporter atp-binding protein
D8668_RS10425	COG0765	amino acid transport
D8668_RS10430	COG0765	amino acid transport
D8668_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS10450	COG0189	ligase activity
D8668_RS10455	COG1982	Orn Lys Arg decarboxylase major
D8668_RS10460	COG2197	response regulator
D8668_RS10470	COG3795	YCII-related domain
D8668_RS10480	COG4941	Belongs to the sigma-70 factor family
D8668_RS10485	COG2814	Major facilitator Superfamily
D8668_RS10495	COG3795	YCII-related domain
D8668_RS10510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D8668_RS10525	COG5006	permease, DMT superfamily
D8668_RS10555	COG0384	phenazine biosynthesis protein PhzF
D8668_RS10570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8668_RS10590	COG1247	-acetyltransferase
D8668_RS10600	COG4221	oxidoreductase activity
D8668_RS10605	COG2207	Transcriptional regulator
D8668_RS10615	COG1450	Type ii and iii secretion system protein
D8668_RS10625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8668_RS10650	COG0438	transferase activity, transferring glycosyl groups
D8668_RS10655	COG0463	Glycosyl transferase, family 2
D8668_RS10660	COG0438	transferase activity, transferring glycosyl groups
D8668_RS10705	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D8668_RS10730	COG0210	DNA helicase
D8668_RS10740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D8668_RS10740	COG0116	Belongs to the methyltransferase superfamily
D8668_RS10745	COG3264	Mechanosensitive ion channel
D8668_RS10745	COG1196	nuclear chromosome segregation
D8668_RS10760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D8668_RS10775	COG0583	DNA-binding transcription factor activity
D8668_RS10785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8668_RS10875	COG3300	MHYT domain
D8668_RS10875	COG5001	Diguanylate cyclase
D8668_RS10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS10890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS10905	COG2832	Protein of unknown function (DUF454)
D8668_RS10945	COG1987	bacterial-type flagellum assembly
D8668_RS10965	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D8668_RS10970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D8668_RS11010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D8668_RS11015	COG1360	Flagellar Motor Protein
D8668_RS11020	COG1192	Involved in chromosome partitioning
D8668_RS11030	COG0835	chemotaxis
D8668_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS11070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D8668_RS11145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D8668_RS11165	COG3192	ethanolamine utilization protein
D8668_RS11175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D8668_RS11190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8668_RS11195	COG4413	Urea transporter
D8668_RS11200	COG0469	pyruvate kinase activity
D8668_RS11210	COG2084	Dehydrogenase
D8668_RS11215	COG3622	Belongs to the hyi family
D8668_RS11220	COG3960	tartronate-semialdehyde synthase activity
D8668_RS11230	COG1309	transcriptional regulator
D8668_RS11245	COG2233	PERMEase
D8668_RS11305	COG2252	PERMEase
D8668_RS11320	COG0402	S-adenosylhomocysteine deaminase activity
D8668_RS11350	COG1196	nuclear chromosome segregation
D8668_RS11395	COG1960	acyl-CoA dehydrogenase activity
D8668_RS11425	COG2076	Multidrug Resistance protein
D8668_RS11465	COG2217	Heavy metal translocating P-type atpase
D8668_RS11475	COG0348	domain, Protein
D8668_RS11485	COG2010	Cytochrome c
D8668_RS11500	COG3278	Belongs to the heme-copper respiratory oxidase family
D8668_RS11505	COG2010	Cytochrome c
D8668_RS11520	COG3278	Belongs to the heme-copper respiratory oxidase family
D8668_RS11535	COG0840	transmembrane signaling receptor activity
D8668_RS11555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS11560	COG0174	glutamine synthetase
D8668_RS11570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS11575	COG0251	oxidation-reduction process
D8668_RS11605	COG3738	Protein conserved in bacteria
D8668_RS11650	COG4804	nuclease activity
D8668_RS11655	COG2003	Belongs to the UPF0758 family
D8668_RS11690	COG5489	Protein of unknown function (DUF736)
D8668_RS11765	COG1127	ABC transporter
D8668_RS11770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8668_RS11805	COG0583	DNA-binding transcription factor activity
D8668_RS11815	COG2076	Multidrug Resistance protein
D8668_RS11845	COG4962	Type ii secretion system protein e
D8668_RS11850	COG3838	Conjugal transfer protein Trbc
D8668_RS11860	COG3451	type IV secretory pathway VirB4
D8668_RS11875	COG3846	protein secretion by the type IV secretion system
D8668_RS11905	COG2009	succinate dehydrogenase
D8668_RS11910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D8668_RS11915	COG1053	succinate dehydrogenase
D8668_RS11920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D8668_RS11995	COG2207	Transcriptional regulator
D8668_RS12005	COG2010	Cytochrome c
D8668_RS12005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D8668_RS12010	COG2080	2 iron, 2 sulfur cluster binding
D8668_RS12015	COG1846	Transcriptional regulator
D8668_RS12055	COG0784	Response regulator, receiver
D8668_RS12055	COG2205	protein histidine kinase activity
D8668_RS12055	COG5002	protein histidine kinase activity
D8668_RS12085	COG1022	Amp-dependent synthetase and ligase
D8668_RS12115	COG0625	glutathione transferase activity
D8668_RS12125	COG0628	permease
D8668_RS12130	COG2807	transmembrane transport
D8668_RS12135	COG2186	Transcriptional regulator
D8668_RS12140	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8668_RS12145	COG1024	Enoyl-CoA hydratase
D8668_RS12155	COG1960	acyl-CoA dehydrogenase activity
D8668_RS12180	COG2205	protein histidine kinase activity
D8668_RS12225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8668_RS12235	COG0840	transmembrane signaling receptor activity
D8668_RS12250	COG2130	NADP-dependent
D8668_RS12265	COG3135	benzoate transporter
D8668_RS12280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8668_RS12285	COG0625	glutathione transferase activity
D8668_RS12295	COG3209	COG3209 Rhs family protein
D8668_RS12355	COG2204	response regulator
D8668_RS12390	COG0631	protein serine/threonine phosphatase activity
D8668_RS12395	COG2815	serine threonine protein kinase
D8668_RS12395	COG0515	serine threonine protein kinase
D8668_RS12415	COG2840	Smr protein MutS2
D8668_RS12495	COG4792	protein secretion
D8668_RS12500	COG4791	protein targeting
D8668_RS12505	COG4794	Type iii secretion
D8668_RS12510	COG4790	Type iii secretion
D8668_RS12565	COG4789	Type iii secretion
D8668_RS12675	COG1317	bacterial-type flagellum organization
D8668_RS12705	COG2308	Evidence 4 Homologs of previously reported genes of
D8668_RS12715	COG1305	Transglutaminase-like
D8668_RS12735	COG0183	Belongs to the thiolase family
D8668_RS12750	COG0667	Aldo Keto reductase
D8668_RS12765	COG0519	Catalyzes the synthesis of GMP from XMP
D8668_RS12820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D8668_RS12855	COG2909	trisaccharide binding
D8668_RS12860	COG2909	trisaccharide binding
D8668_RS12905	COG0189	ligase activity
D8668_RS12905	COG4067	protein conserved in archaea
D8668_RS12945	COG0668	transmembrane transport
D8668_RS12965	COG0243	molybdopterin cofactor binding
D8668_RS12970	COG2146	nitrite reductase [NAD(P)H] activity
D8668_RS12975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8668_RS12980	COG0515	serine threonine protein kinase
D8668_RS12985	COG2223	nitrite transmembrane transporter activity
D8668_RS12995	COG2201	protein-glutamate methylesterase activity
D8668_RS13020	COG0589	response to stress
D8668_RS13040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D8668_RS13085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D8668_RS13090	COG2205	protein histidine kinase activity
D8668_RS13095	COG0745	RESPONSE REGULATOR receiver
D8668_RS13120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D8668_RS13135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8668_RS13145	COG4172	Belongs to the ABC transporter superfamily
D8668_RS13150	COG4239	(ABC) transporter, permease
D8668_RS13155	COG4174	ABC transporter (Permease)
D8668_RS13160	COG4166	transmembrane transport
D8668_RS13165	COG4166	transmembrane transport
D8668_RS13170	COG1388	LysM domain
D8668_RS13170	COG0741	lytic transglycosylase activity
D8668_RS13190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8668_RS13205	COG0531	amino acid
D8668_RS13215	COG1024	Enoyl-CoA hydratase
D8668_RS13240	COG0583	DNA-binding transcription factor activity
D8668_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS13270	COG0616	signal peptide processing
D8668_RS13275	COG0604	alcohol dehydrogenase
D8668_RS13300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8668_RS13365	COG3813	Protein conserved in bacteria
D8668_RS13370	COG4977	sequence-specific DNA binding
D8668_RS13375	COG2203	Gaf domain
D8668_RS13375	COG5001	Diguanylate cyclase
D8668_RS13375	COG4251	negative regulation of phosphorylation
D8668_RS13375	COG3706	GGDEF domain
D8668_RS13390	COG2239	Acts as a magnesium transporter
D8668_RS13400	COG3278	Belongs to the heme-copper respiratory oxidase family
D8668_RS13405	COG2354	Protein conserved in bacteria
D8668_RS13410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8668_RS13420	COG0583	DNA-binding transcription factor activity
D8668_RS13425	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D8668_RS13445	COG1309	transcriptional regulator
D8668_RS13515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS13580	COG0625	glutathione transferase activity
D8668_RS13595	COG2366	antibiotic biosynthetic process
D8668_RS13620	COG2197	response regulator
D8668_RS13695	COG1595	DNA-templated transcription, initiation
D8668_RS13730	COG0579	oxidoreductase
D8668_RS13745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8668_RS13745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D8668_RS13750	COG0275	rRNA processing
D8668_RS13755	COG4771	TonB-dependent receptor
D8668_RS13775	COG1944	ATP diphosphatase activity
D8668_RS13800	COG2080	2 iron, 2 sulfur cluster binding
D8668_RS13805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D8668_RS13810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D8668_RS13825	COG0753	catalase activity
D8668_RS13830	COG2010	Cytochrome c
D8668_RS13850	COG2204	response regulator
D8668_RS13855	COG1879	ABC-type sugar transport system periplasmic component
D8668_RS13865	COG1172	Belongs to the binding-protein-dependent transport system permease family
D8668_RS13870	COG1609	Transcriptional regulator
D8668_RS13875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D8668_RS13925	COG1278	Cold shock
D8668_RS13930	COG0583	DNA-binding transcription factor activity
D8668_RS13945	COG0488	(ABC) transporter
D8668_RS13990	COG2194	sulfuric ester hydrolase activity
D8668_RS14010	COG0784	Response regulator, receiver
D8668_RS14010	COG2205	protein histidine kinase activity
D8668_RS14025	COG3851	Histidine kinase
D8668_RS14090	COG2205	protein histidine kinase activity
D8668_RS14110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8668_RS14115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8668_RS14120	COG0583	DNA-binding transcription factor activity
D8668_RS14125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D8668_RS14140	COG2031	fatty acid transporter
D8668_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS14150	COG2610	gluconate transmembrane transporter activity
D8668_RS14155	COG3290	protein histidine kinase activity
D8668_RS14155	COG3829	transcription factor binding
D8668_RS14160	COG2271	Major facilitator Superfamily
D8668_RS14170	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8668_RS14200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8668_RS14205	COG1960	acyl-CoA dehydrogenase activity
D8668_RS14210	COG0789	Transcriptional regulator
D8668_RS14215	COG3204	pilus organization
D8668_RS14225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS14235	COG1309	transcriptional regulator
D8668_RS14275	COG1522	sequence-specific DNA binding
D8668_RS14295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8668_RS14310	COG0028	Belongs to the TPP enzyme family
D8668_RS14335	COG0174	glutamine synthetase
D8668_RS14340	COG0531	amino acid
D8668_RS14355	COG0564	pseudouridine synthase activity
D8668_RS14375	COG2207	Transcriptional regulator
D8668_RS14390	COG1595	DNA-templated transcription, initiation
D8668_RS14430	COG4771	TonB-dependent receptor
D8668_RS14445	COG4239	(ABC) transporter, permease
D8668_RS14450	COG4172	Belongs to the ABC transporter superfamily
D8668_RS14455	COG1104	cysteine desulfurase activity
D8668_RS14485	COG2814	Major facilitator Superfamily
D8668_RS14490	COG2192	nodulation
D8668_RS14510	COG5001	Diguanylate cyclase
D8668_RS14515	COG3153	acetyltransferase
D8668_RS14515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D8668_RS14535	COG2010	Cytochrome c
D8668_RS14540	COG2010	Cytochrome c
D8668_RS14550	COG1113	amino acid transport
D8668_RS14570	COG1522	sequence-specific DNA binding
D8668_RS14580	COG0367	asparagine synthase
D8668_RS14585	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D8668_RS14590	COG0596	Alpha beta hydrolase
D8668_RS14610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8668_RS14620	COG2814	Major facilitator Superfamily
D8668_RS14655	COG0300	oxidoreductase activity
D8668_RS14665	COG0028	Belongs to the TPP enzyme family
D8668_RS14675	COG1984	allophanate hydrolase subunit 2
D8668_RS14695	COG2814	Major facilitator Superfamily
D8668_RS14700	COG0583	DNA-binding transcription factor activity
D8668_RS14720	COG2169	Transcriptional regulator
D8668_RS14720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8668_RS14755	COG0583	DNA-binding transcription factor activity
D8668_RS14760	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D8668_RS14765	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS14770	COG1475	DNA binding
D8668_RS14780	COG3969	phosphoadenosine phosphosulfate
D8668_RS14790	COG3121	Chaperone
D8668_RS14805	COG3121	Chaperone
D8668_RS14825	COG2323	membrane
D8668_RS14855	COG1546	Belongs to the CinA family
D8668_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS14875	COG0058	SHG alpha-glucan phosphorylase activity
D8668_RS14900	COG1285	pathogenesis
D8668_RS14920	COG0366	Alpha amylase catalytic
D8668_RS14930	COG0392	lysyltransferase activity
D8668_RS14935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8668_RS14940	COG3568	Endonuclease Exonuclease Phosphatase
D8668_RS14985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D8668_RS15025	COG1363	Peptidase, m42
D8668_RS15055	COG0784	Response regulator, receiver
D8668_RS15055	COG4191	Histidine kinase
D8668_RS15070	COG2890	protein-(glutamine-N5) methyltransferase activity
D8668_RS15105	COG0517	IMP dehydrogenase activity
D8668_RS15110	COG0366	Alpha amylase catalytic
D8668_RS15130	COG1309	transcriptional regulator
D8668_RS15135	COG2130	NADP-dependent
D8668_RS15145	COG2084	Dehydrogenase
D8668_RS15160	COG0765	amino acid transport
D8668_RS15165	COG0765	amino acid transport
D8668_RS15170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS15250	COG4644	lycopene metabolic process
D8668_RS15265	COG2271	Major facilitator Superfamily
D8668_RS15270	COG3618	amidohydrolase
D8668_RS15285	COG2271	Major facilitator Superfamily
D8668_RS15290	COG4948	Mandelate Racemase Muconate Lactonizing
D8668_RS15305	COG2995	paraquat-inducible protein a
D8668_RS15310	COG3008	intermembrane lipid transfer
D8668_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS15350	COG3162	membrane
D8668_RS15355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8668_RS15370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8668_RS15375	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS15380	COG0531	amino acid
D8668_RS15395	COG2072	flavoprotein involved in K transport
D8668_RS15410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS15480	COG1484	DNA-dependent DNA replication
D8668_RS15485	COG4584	PFAM Integrase catalytic
D8668_RS15515	COG2409	Drug exporters of the RND superfamily
D8668_RS15520	COG4447	cellulose binding
D8668_RS15530	COG2508	Transcriptional regulator
D8668_RS15595	COG5642	Protein of unknown function (DUF2384)
D8668_RS15645	COG2258	MOSC domain
D8668_RS15710	COG0728	peptidoglycan biosynthetic process
D8668_RS15720	COG1053	succinate dehydrogenase
D8668_RS15765	COG1115	amino acid carrier protein
D8668_RS15770	COG0252	asparaginase activity
D8668_RS15805	COG1609	Transcriptional regulator
D8668_RS15815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D8668_RS15850	COG0504	CTP synthase activity
D8668_RS15860	COG1309	transcriptional regulator
D8668_RS15885	COG1064	alcohol dehydrogenase
D8668_RS15890	COG2207	Transcriptional regulator
D8668_RS15895	COG0640	Transcriptional regulator
D8668_RS15905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8668_RS15910	COG0431	NADPH-dependent FMN reductase
D8668_RS15955	COG4772	TonB-dependent receptor
D8668_RS15995	COG1053	succinate dehydrogenase
D8668_RS16000	COG2188	Transcriptional regulator
D8668_RS16005	COG3469	chitinase activity
D8668_RS16040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8668_RS16045	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8668_RS16055	COG2175	clavaminate synthase activity
D8668_RS16065	COG1396	sequence-specific DNA binding
D8668_RS16085	COG0583	DNA-binding transcription factor activity
D8668_RS16090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS16100	COG1609	Transcriptional regulator
D8668_RS16105	COG3265	gluconokinase activity
D8668_RS16120	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS16140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8668_RS16145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS16150	COG1116	anion transmembrane transporter activity
D8668_RS16165	COG1917	Cupin 2, conserved barrel domain protein
D8668_RS16165	COG4977	sequence-specific DNA binding
D8668_RS16180	COG1175	transmembrane transport
D8668_RS16195	COG0246	Mannitol dehydrogenase
D8668_RS16205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D8668_RS16230	COG1464	Belongs to the NlpA lipoprotein family
D8668_RS16240	COG2011	ABC-type metal ion transport system permease component
D8668_RS16250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D8668_RS16255	COG3829	transcription factor binding
D8668_RS16280	COG3829	transcription factor binding
D8668_RS16370	COG4566	intracellular signal transduction
D8668_RS16400	COG1304	FMN binding
D8668_RS16410	COG0735	belongs to the Fur family
D8668_RS16435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS16480	COG4774	siderophore transport
D8668_RS16485	COG0657	acetylesterase activity
D8668_RS16525	COG1121	(ABC) transporter
D8668_RS16530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D8668_RS16570	COG0583	DNA-binding transcription factor activity
D8668_RS16580	COG1335	isochorismatase
D8668_RS16665	COG1566	PFAM secretion protein HlyD family protein
D8668_RS16685	COG0583	DNA-binding transcription factor activity
D8668_RS16700	COG2217	Heavy metal translocating P-type atpase
D8668_RS16740	COG1760	l-serine dehydratase
D8668_RS16765	COG0583	DNA-binding transcription factor activity
D8668_RS16785	COG2382	esterase
D8668_RS16795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8668_RS16910	COG3712	iron ion homeostasis
D8668_RS16915	COG1595	DNA-templated transcription, initiation
D8668_RS16920	COG0583	DNA-binding transcription factor activity
D8668_RS16940	COG0625	glutathione transferase activity
D8668_RS16975	COG0642	Histidine kinase
D8668_RS16985	COG3258	Cytochrome c
D8668_RS16990	COG2863	cytochrome
D8668_RS16995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8668_RS17060	COG2318	DinB family
D8668_RS17075	COG0590	tRNA wobble adenosine to inosine editing
D8668_RS17080	COG2807	transmembrane transport
D8668_RS17115	COG3485	protocatechuate 3,4-dioxygenase
D8668_RS17125	COG4948	Mandelate Racemase Muconate Lactonizing
D8668_RS17150	COG4638	Rieske (2fe-2S)
D8668_RS17155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D8668_RS17160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8668_RS17160	COG0543	2 iron, 2 sulfur cluster binding
D8668_RS17220	COG1538	Outer membrane efflux protein
D8668_RS17225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS17230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS17270	COG1115	amino acid carrier protein
D8668_RS17280	COG0667	Aldo Keto reductase
D8668_RS17285	COG4589	Belongs to the CDS family
D8668_RS17300	COG0671	phosphoesterase, PA-phosphatase related
D8668_RS17300	COG2453	phosphatase
D8668_RS17305	COG2267	carboxylic ester hydrolase activity
D8668_RS17310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D8668_RS17320	COG0729	surface antigen
D8668_RS17370	COG1960	acyl-CoA dehydrogenase activity
D8668_RS17375	COG0183	Belongs to the thiolase family
D8668_RS17385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8668_RS17395	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS17430	COG0659	secondary active sulfate transmembrane transporter activity
D8668_RS17455	COG4251	negative regulation of phosphorylation
D8668_RS17455	COG2203	Gaf domain
D8668_RS17455	COG3706	GGDEF domain
D8668_RS17455	COG5001	Diguanylate cyclase
D8668_RS17480	COG4191	Histidine kinase
D8668_RS17510	COG1522	sequence-specific DNA binding
D8668_RS17525	COG2249	NAD(P)H dehydrogenase (quinone) activity
D8668_RS17545	COG2205	protein histidine kinase activity
D8668_RS17545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS17600	COG2197	response regulator
D8668_RS17615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS17625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS17630	COG1960	acyl-CoA dehydrogenase activity
D8668_RS17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS17645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8668_RS17650	COG0583	DNA-binding transcription factor activity
D8668_RS17690	COG2920	part of a sulfur-relay system
D8668_RS17695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D8668_RS17700	COG0435	Glutathione S-transferase
D8668_RS17715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8668_RS17730	COG0492	ferredoxin-NADP+ reductase activity
D8668_RS17745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D8668_RS17750	COG0542	response to heat
D8668_RS17760	COG1278	Cold shock
D8668_RS17800	COG2850	peptidyl-arginine hydroxylation
D8668_RS17805	COG2153	protein acetylation
D8668_RS17905	COG2226	methyltransferase
D8668_RS17920	COG2056	Na+-H+ antiporter family
D8668_RS17925	COG0840	transmembrane signaling receptor activity
D8668_RS17985	COG3604	Transcriptional regulator
D8668_RS17990	COG0720	synthase
D8668_RS18040	COG1459	type II secretion system
D8668_RS18045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D8668_RS18055	COG4106	trans-aconitate 2-methyltransferase activity
D8668_RS18065	COG0583	DNA-binding transcription factor activity
D8668_RS18110	COG2819	hydrolase of the alpha beta superfamily
D8668_RS18120	COG1959	2 iron, 2 sulfur cluster binding
D8668_RS18125	COG1607	acyl-coa hydrolase
D8668_RS18200	COG0542	response to heat
D8668_RS18215	COG1280	lysine exporter protein (LysE YggA)
D8668_RS18240	COG0243	molybdopterin cofactor binding
D8668_RS18245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D8668_RS18260	COG0789	Transcriptional regulator
D8668_RS18305	COG0542	response to heat
D8668_RS18315	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D8668_RS18315	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D8668_RS18325	COG3328	transposase activity
D8668_RS18345	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D8668_RS18355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D8668_RS18475	COG5377	YqaJ viral recombinase family
D8668_RS18500	COG2003	Belongs to the UPF0758 family
D8668_RS18605	COG0024	Methionine aminopeptidase
D8668_RS18635	COG1295	ribonuclease BN
D8668_RS18645	COG1238	metal cluster binding
D8668_RS18730	COG2837	iron assimilation
D8668_RS18740	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8668_RS18740	COG1024	Enoyl-CoA hydratase
D8668_RS18750	COG1051	belongs to the nudix hydrolase family
D8668_RS18805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS18810	COG2116	formate transmembrane transporter activity
D8668_RS18860	COG3655	Transcriptional regulator
D8668_RS18875	COG0840	transmembrane signaling receptor activity
D8668_RS18935	COG4974	Belongs to the 'phage' integrase family
D8668_RS19000	COG0745	RESPONSE REGULATOR receiver
D8668_RS19010	COG2853	Lipoprotein
D8668_RS19020	COG2188	Transcriptional regulator
D8668_RS19065	COG0842	Transport permease protein
D8668_RS19070	COG1131	(ABC) transporter
D8668_RS19075	COG0625	glutathione transferase activity
D8668_RS19195	COG0629	single-stranded DNA binding
D8668_RS19295	COG0488	(ABC) transporter
D8668_RS19320	COG1320	monovalent cation:proton antiporter activity
D8668_RS19335	COG0651	ATP synthesis coupled electron transport
D8668_RS19340	COG0651	ATP synthesis coupled electron transport
D8668_RS19345	COG1006	Multisubunit Na H antiporter MnhC subunit
D8668_RS19350	COG2111	Na H antiporter
D8668_RS19355	COG2111	Na H antiporter
D8668_RS19355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8668_RS19380	COG0210	DNA helicase
D8668_RS19560	COG2003	Belongs to the UPF0758 family
D8668_RS19625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D8668_RS19655	COG0583	DNA-binding transcription factor activity
D8668_RS19660	COG0582	viral genome integration into host DNA
D8668_RS19680	COG0625	glutathione transferase activity
D8668_RS19685	COG1956	GAF domain-containing protein
D8668_RS19690	COG2255	four-way junction helicase activity
D8668_RS19695	COG0784	Response regulator, receiver
D8668_RS19695	COG2205	protein histidine kinase activity
D8668_RS19695	COG5002	protein histidine kinase activity
D8668_RS19700	COG1846	Transcriptional regulator
D8668_RS19705	COG0386	Belongs to the glutathione peroxidase family
D8668_RS19715	COG0436	Aminotransferase
D8668_RS19730	COG2866	Carboxypeptidase
D8668_RS19770	COG3384	dioxygenase
D8668_RS19780	COG1024	Enoyl-CoA hydratase
D8668_RS19790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D8668_RS19795	COG3214	Protein conserved in bacteria
D8668_RS19805	COG0583	DNA-binding transcription factor activity
D8668_RS19815	COG0583	DNA-binding transcription factor activity
D8668_RS19820	COG1846	Transcriptional regulator
D8668_RS19825	COG1764	response to oxidative stress
D8668_RS19885	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D8668_RS19900	COG2259	Doxx family
D8668_RS19905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D8668_RS19910	COG0084	hydrolase, TatD family'
D8668_RS19955	COG0714	Associated with various cellular activities
D8668_RS19965	COG0583	DNA-binding transcription factor activity
D8668_RS20005	COG1309	transcriptional regulator
D8668_RS20020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8668_RS20025	COG1960	acyl-CoA dehydrogenase activity
D8668_RS20030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D8668_RS20045	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS20060	COG1595	DNA-templated transcription, initiation
D8668_RS20065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8668_RS20075	COG2197	response regulator
D8668_RS20080	COG2885	chlorophyll binding
D8668_RS20080	COG3047	cAMP biosynthetic process
D8668_RS20140	COG1120	ATPase activity
D8668_RS20150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8668_RS20185	COG0583	DNA-binding transcription factor activity
D8668_RS20190	COG1473	amidohydrolase
D8668_RS20195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS20200	COG4215	(ABC) transporter
D8668_RS20205	COG4160	amino acid transport
D8668_RS20240	COG1309	transcriptional regulator
D8668_RS20245	COG1902	pentaerythritol trinitrate reductase activity
D8668_RS20250	COG2814	Major facilitator Superfamily
D8668_RS20275	COG2233	PERMEase
D8668_RS20290	COG0183	Belongs to the thiolase family
D8668_RS20305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D8668_RS20390	COG0084	hydrolase, TatD family'
D8668_RS20410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D8668_RS20420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8668_RS20450	COG1399	metal-binding, possibly nucleic acid-binding protein
D8668_RS20460	COG0616	signal peptide processing
D8668_RS20460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D8668_RS20490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8668_RS20510	COG0848	biopolymer transport protein
D8668_RS20515	COG0811	peptide transport
D8668_RS20540	COG4591	ABC-type transport system involved in lipoprotein release permease component
D8668_RS20555	COG0584	glycerophosphoryl diester phosphodiesterase
D8668_RS20570	COG1477	protein flavinylation
D8668_RS20605	COG1113	amino acid transport
D8668_RS20615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8668_RS20695	COG0589	response to stress
D8668_RS20705	COG0488	(ABC) transporter
D8668_RS20710	COG0741	lytic transglycosylase activity
D8668_RS20730	COG1070	Carbohydrate kinase
D8668_RS20735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D8668_RS20755	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8668_RS20785	COG1309	transcriptional regulator
D8668_RS20790	COG0625	glutathione transferase activity
D8668_RS20800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8668_RS20810	COG0004	ammonium transporteR
D8668_RS20840	COG2205	protein histidine kinase activity
D8668_RS20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS20845	COG2197	response regulator
D8668_RS20850	COG3171	Protein conserved in bacteria
D8668_RS20855	COG2027	D-alanyl-D-alanine carboxypeptidase
D8668_RS20870	COG3130	regulation of translation
D8668_RS20920	COG0297	glycogen (starch) synthase activity
D8668_RS20945	COG2342	PFAM TM1410 hypothetical-related protein
D8668_RS20960	COG0714	Associated with various cellular activities
D8668_RS20995	COG0745	RESPONSE REGULATOR receiver
D8668_RS21030	COG0308	aminopeptidase N
D8668_RS21040	COG3139	Protein of unknown function (DUF1315)
D8668_RS21050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8668_RS21175	COG1286	toxin biosynthetic process
D8668_RS21180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D8668_RS21185	COG0285	dihydrofolate synthase activity
D8668_RS21225	COG2226	methyltransferase
D8668_RS21245	COG0251	oxidation-reduction process
D8668_RS21250	COG0583	DNA-binding transcription factor activity
D8668_RS21270	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS21285	COG0800	Aldolase
D8668_RS21290	COG0596	Alpha beta hydrolase
D8668_RS21325	COG0583	DNA-binding transcription factor activity
D8668_RS21365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8668_RS21390	COG1086	Polysaccharide biosynthesis protein
D8668_RS21440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D8668_RS21470	COG0402	S-adenosylhomocysteine deaminase activity
D8668_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS21500	COG0786	glutamate:sodium symporter activity
D8668_RS21550	COG0676	glucose-6-phosphate 1-epimerase activity
D8668_RS21565	COG3842	ATPase activity
D8668_RS21570	COG0395	ABC-type sugar transport system, permease component
D8668_RS21575	COG1175	transmembrane transport
D8668_RS21625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D8668_RS21630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D8668_RS21635	COG0009	L-threonylcarbamoyladenylate synthase
D8668_RS21640	COG0613	PHP domain protein
D8668_RS21650	COG2350	Protein conserved in bacteria
D8668_RS21660	COG0745	RESPONSE REGULATOR receiver
D8668_RS21680	COG0778	Nitroreductase
D8668_RS21685	COG0727	PFAM Uncharacterised protein family (UPF0153)
D8668_RS21690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8668_RS21695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8668_RS21700	COG1127	ABC transporter
D8668_RS21730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D8668_RS21730	COG0438	transferase activity, transferring glycosyl groups
D8668_RS21745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8668_RS21770	COG0702	epimerase
D8668_RS21775	COG0509	glycine decarboxylation via glycine cleavage system
D8668_RS21800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8668_RS21810	COG1132	(ABC) transporter
D8668_RS21840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8668_RS21845	COG3162	membrane
D8668_RS21865	COG2853	Lipoprotein
D8668_RS21880	COG1560	Kdo2-lipid A biosynthetic process
D8668_RS21890	COG2894	cell division
D8668_RS21900	COG0564	pseudouridine synthase activity
D8668_RS21930	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8668_RS21945	COG0560	Phosphoserine phosphatase
D8668_RS21950	COG0604	alcohol dehydrogenase
D8668_RS21950	COG3321	synthase
D8668_RS21960	COG2200	EAL domain
D8668_RS22010	COG0385	Bile acid
D8668_RS22015	COG2076	Multidrug Resistance protein
D8668_RS22030	COG4772	TonB-dependent receptor
D8668_RS22045	COG2205	protein histidine kinase activity
D8668_RS22050	COG1201	RNA secondary structure unwinding
D8668_RS22125	COG1595	DNA-templated transcription, initiation
D8668_RS22180	COG0537	adenosine 5'-monophosphoramidase activity
D8668_RS22190	COG1643	Atp-dependent helicase
D8668_RS22205	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS22210	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS22215	COG2267	carboxylic ester hydrolase activity
D8668_RS22220	COG2030	dehydratase
D8668_RS22225	COG2814	Major facilitator Superfamily
D8668_RS22265	COG0589	response to stress
D8668_RS22280	COG2084	Dehydrogenase
D8668_RS22285	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D8668_RS22295	COG3639	organic phosphonate transmembrane transporter activity
D8668_RS22330	COG0583	DNA-binding transcription factor activity
D8668_RS22420	COG1752	Esterase of the alpha-beta hydrolase superfamily
D8668_RS22445	COG2203	Gaf domain
D8668_RS22445	COG3706	GGDEF domain
D8668_RS22445	COG4251	negative regulation of phosphorylation
D8668_RS22445	COG5001	Diguanylate cyclase
D8668_RS22450	COG0514	ATP-dependent DNA helicase (RecQ)
D8668_RS22460	COG0745	RESPONSE REGULATOR receiver
D8668_RS22475	COG0835	chemotaxis
D8668_RS22475	COG0784	Response regulator, receiver
D8668_RS22495	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D8668_RS22520	COG0697	spore germination
D8668_RS22605	COG3454	Phosphonate metabolism
D8668_RS22610	COG4778	phosphonate C-P lyase system protein PhnL
D8668_RS22615	COG4107	phosphonate C-P lyase system protein PhnK
D8668_RS22620	COG3627	carbon phosphorus lyase activity
D8668_RS22625	COG3626	phosphonate metabolism
D8668_RS22635	COG3624	Phosphonate C-P lyase system protein PhnG
D8668_RS22640	COG2188	Transcriptional regulator
D8668_RS22645	COG3639	organic phosphonate transmembrane transporter activity
D8668_RS22650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D8668_RS22725	COG0583	DNA-binding transcription factor activity
D8668_RS22780	COG1629	transport
D8668_RS22870	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D8668_RS22880	COG1024	Enoyl-CoA hydratase
D8668_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS22915	COG0583	DNA-binding transcription factor activity
D8668_RS22940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D8668_RS22965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8668_RS22975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS22980	COG0431	NADPH-dependent FMN reductase
D8668_RS22990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8668_RS22995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS23000	COG0450	alkyl hydroperoxide reductase
D8668_RS23020	COG0183	Belongs to the thiolase family
D8668_RS23050	COG0367	asparagine synthase
D8668_RS23055	COG0189	ligase activity
D8668_RS23055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D8668_RS23060	COG1363	Peptidase, m42
D8668_RS23065	COG5002	protein histidine kinase activity
D8668_RS23065	COG0784	Response regulator, receiver
D8668_RS23065	COG2205	protein histidine kinase activity
D8668_RS23090	COG0477	Major facilitator Superfamily
D8668_RS23095	COG0668	transmembrane transport
D8668_RS23100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D8668_RS23120	COG0791	NLP P60 protein
D8668_RS23170	COG0489	protein tyrosine kinase activity
D8668_RS23240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D8668_RS23250	COG2264	protein methyltransferase activity
D8668_RS23255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D8668_RS23290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS23320	COG0450	alkyl hydroperoxide reductase
D8668_RS23335	COG2223	nitrite transmembrane transporter activity
D8668_RS23340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D8668_RS23345	COG0243	molybdopterin cofactor binding
D8668_RS23365	COG3842	ATPase activity
D8668_RS23485	COG1105	Belongs to the carbohydrate kinase PfkB family
D8668_RS23495	COG1609	Transcriptional regulator
D8668_RS23500	COG0084	hydrolase, TatD family'
D8668_RS23510	COG0583	DNA-binding transcription factor activity
D8668_RS23550	COG2814	Major facilitator Superfamily
D8668_RS23600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D8668_RS23640	COG0583	DNA-binding transcription factor activity
D8668_RS23655	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8668_RS23660	COG1024	Enoyl-CoA hydratase
D8668_RS23665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8668_RS23670	COG1960	acyl-CoA dehydrogenase activity
D8668_RS23675	COG0583	DNA-binding transcription factor activity
D8668_RS23685	COG0477	Major facilitator Superfamily
D8668_RS23690	COG2169	Transcriptional regulator
D8668_RS23690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8668_RS23695	COG0531	amino acid
D8668_RS23720	COG0069	glutamate synthase activity
D8668_RS23740	COG3148	PFAM DTW domain containing protein
D8668_RS23750	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8668_RS23755	COG1177	transmembrane transport
D8668_RS23770	COG3530	Putative quorum-sensing-regulated virulence factor
D8668_RS23775	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D8668_RS23780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D8668_RS23800	COG1546	Belongs to the CinA family
D8668_RS23855	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D8668_RS23860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D8668_RS23865	COG0583	DNA-binding transcription factor activity
D8668_RS23870	COG2391	methyltransferase activity
D8668_RS23920	COG1115	amino acid carrier protein
D8668_RS24000	COG0024	Methionine aminopeptidase
D8668_RS24010	COG0436	Aminotransferase
D8668_RS24015	COG0025	NhaP-type Na H and K H
D8668_RS24035	COG1393	Belongs to the ArsC family
D8668_RS24040	COG1280	lysine exporter protein (LysE YggA)
D8668_RS24055	COG2166	iron-sulfur cluster assembly
D8668_RS24100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS24125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D8668_RS24130	COG1801	Protein of unknown function DUF72
D8668_RS24140	COG1214	PFAM Peptidase M22, glycoprotease
D8668_RS24160	COG0789	Transcriptional regulator
D8668_RS24175	COG2885	chlorophyll binding
D8668_RS24190	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D8668_RS24190	COG1073	alpha beta
D8668_RS24190	COG3064	Membrane
D8668_RS24260	COG0477	Major facilitator Superfamily
D8668_RS24280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D8668_RS24285	COG2197	response regulator
D8668_RS24330	COG1902	pentaerythritol trinitrate reductase activity
D8668_RS24340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8668_RS24355	COG2255	four-way junction helicase activity
D8668_RS24380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8668_RS24405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8668_RS24425	COG1607	acyl-coa hydrolase
D8668_RS24450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8668_RS24460	COG4536	flavin adenine dinucleotide binding
D8668_RS24470	COG0477	Major facilitator Superfamily
D8668_RS24510	COG2188	Transcriptional regulator
D8668_RS24515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D8668_RS24520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D8668_RS24570	COG0590	tRNA wobble adenosine to inosine editing
D8668_RS24575	COG2132	Multicopper oxidase
D8668_RS24625	COG0583	DNA-binding transcription factor activity
D8668_RS24630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8668_RS24640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D8668_RS24655	COG1335	isochorismatase
D8668_RS24665	COG2847	Copper chaperone PCu(A)C
D8668_RS24675	COG0739	heme binding
D8668_RS24715	COG0667	Aldo Keto reductase
D8668_RS24730	COG0436	Aminotransferase
D8668_RS24820	COG1045	serine acetyltransferase
D8668_RS24835	COG3134	Outer membrane lipoprotein
D8668_RS24850	COG1862	Preprotein translocase
D8668_RS24870	COG2200	EAL domain
D8668_RS24880	COG0795	lipopolysaccharide-transporting ATPase activity
D8668_RS24885	COG0795	lipopolysaccharide-transporting ATPase activity
D8668_RS24930	COG4120	Belongs to the binding-protein-dependent transport system permease family
D8668_RS24935	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D8668_RS24940	COG0490	domain, Protein
D8668_RS24940	COG0471	metal ion transport
D8668_RS24965	COG0640	Transcriptional regulator
D8668_RS24980	COG0583	DNA-binding transcription factor activity
D8668_RS25045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS25055	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS25085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS25105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8668_RS25110	COG2181	nitrate reductase activity
D8668_RS25115	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D8668_RS25120	COG1140	nitrate reductase beta subunit
D8668_RS25125	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D8668_RS25130	COG2223	nitrite transmembrane transporter activity
D8668_RS25140	COG3850	Histidine kinase
D8668_RS25145	COG2197	response regulator
D8668_RS25160	COG2226	methyltransferase
D8668_RS25220	COG1566	PFAM secretion protein HlyD family protein
D8668_RS25240	COG0583	DNA-binding transcription factor activity
D8668_RS25250	COG0697	spore germination
D8668_RS25260	COG1595	DNA-templated transcription, initiation
D8668_RS25265	COG3712	iron ion homeostasis
D8668_RS25270	COG4772	TonB-dependent receptor
D8668_RS25320	COG3154	lipid carrier protein
D8668_RS25325	COG0826	peptidase U32
D8668_RS25330	COG0826	peptidase U32
D8668_RS25340	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8668_RS25350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D8668_RS25375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D8668_RS25410	COG0318	PFAM AMP-dependent synthetase and ligase
D8668_RS25415	COG0183	Belongs to the thiolase family
D8668_RS25425	COG2207	Transcriptional regulator
D8668_RS25435	COG1294	oxidase, subunit
D8668_RS25440	COG1271	oxidase subunit
D8668_RS25455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8668_RS25460	COG1297	OPT oligopeptide transporter protein
D8668_RS25465	COG2175	clavaminate synthase activity
D8668_RS25470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8668_RS25480	COG4521	taurine ABC transporter
D8668_RS25500	COG1946	Acyl-CoA thioesterase
D8668_RS25520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8668_RS25520	COG2205	protein histidine kinase activity
D8668_RS25525	COG2202	Pas domain
D8668_RS25525	COG2199	diguanylate cyclase activity
D8668_RS25525	COG2200	EAL domain
D8668_RS25530	COG2197	response regulator
D8668_RS25545	COG0513	Belongs to the DEAD box helicase family
D8668_RS25555	COG3416	Protein conserved in bacteria
D8668_RS25650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8668_RS25660	COG1960	acyl-CoA dehydrogenase activity
D8668_RS25670	COG0784	Response regulator, receiver
D8668_RS25670	COG2198	Histidine kinase
D8668_RS25670	COG2205	protein histidine kinase activity
D8668_RS25675	COG0351	phosphomethylpyrimidine kinase
D8668_RS25705	COG1702	phosphate starvation-inducible protein PhoH
D8668_RS25715	COG4535	Mg2 and Co2 transporter CorC
D8668_RS25725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D8668_RS25760	COG2951	lytic endotransglycosylase activity
D8668_RS25795	COG1686	Belongs to the peptidase S11 family
D8668_RS25805	COG2951	lytic endotransglycosylase activity
D8668_RS25810	COG0772	Belongs to the SEDS family
D8668_RS25815	COG0768	penicillin binding
D8668_RS25855	COG0586	Pfam SNARE associated Golgi protein
D8668_RS25865	COG1346	cytolysis
D8668_RS25885	COG0702	epimerase
D8668_RS25900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8668_RS25905	COG3284	Transcriptional regulator
D8668_RS25915	COG0531	amino acid
D8668_RS25920	COG4303	Ethanolamine ammonia lyase large subunit
D8668_RS25930	COG0456	acetyltransferase
D8668_RS25945	COG0586	Pfam SNARE associated Golgi protein
D8668_RS25950	COG3228	Belongs to the MtfA family
D8668_RS25960	COG0745	RESPONSE REGULATOR receiver
D8668_RS25985	COG1131	(ABC) transporter
D8668_RS26005	COG4948	Mandelate Racemase Muconate Lactonizing
D8668_RS26015	COG0142	geranyltranstransferase activity
D8668_RS26025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8668_RS26040	COG3577	Aspartyl protease
D8668_RS26050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D8668_RS26055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D8668_RS26080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8668_RS26080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8668_RS26100	COG2264	protein methyltransferase activity
D8668_RS26105	COG3118	belongs to the thioredoxin family
D8668_RS26135	COG3047	cAMP biosynthetic process
D8668_RS26145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8668_RS26165	COG0531	amino acid
D8668_RS26205	COG2197	response regulator
D8668_RS26225	COG3188	usher protein
D8668_RS26230	COG3121	Chaperone
D8668_RS26245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8668_RS26250	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS26290	COG1063	alcohol dehydrogenase
D8668_RS26295	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS26315	COG0583	DNA-binding transcription factor activity
D8668_RS26365	COG1611	Belongs to the LOG family
D8668_RS26405	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS26410	COG3384	dioxygenase
D8668_RS26420	COG2271	Major facilitator Superfamily
D8668_RS26425	COG3971	2-oxopent-4-enoate hydratase activity
D8668_RS26440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8668_RS26450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8668_RS26455	COG3278	Belongs to the heme-copper respiratory oxidase family
D8668_RS26465	COG1846	Transcriptional regulator
D8668_RS26470	COG2814	Major facilitator Superfamily
D8668_RS26505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS26530	COG3284	Transcriptional regulator
D8668_RS26545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8668_RS26560	COG1063	alcohol dehydrogenase
D8668_RS26565	COG4991	sh3 domain protein
D8668_RS26570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8668_RS26575	COG4774	siderophore transport
D8668_RS26575	COG1629	transport
D8668_RS26585	COG1120	ATPase activity
D8668_RS26590	COG4592	Periplasmic binding protein
D8668_RS26595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8668_RS26600	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8668_RS26610	COG0154	amidase activity
D8668_RS26640	COG1959	2 iron, 2 sulfur cluster binding
D8668_RS26645	COG0492	ferredoxin-NADP+ reductase activity
D8668_RS26650	COG0693	protein deglycase activity
D8668_RS26660	COG0251	oxidation-reduction process
D8668_RS26675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8668_RS26685	COG2226	methyltransferase
D8668_RS26735	COG2271	Major facilitator Superfamily
D8668_RS26740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8668_RS26755	COG4566	intracellular signal transduction
D8668_RS26760	COG4191	Histidine kinase
D8668_RS26770	COG1960	acyl-CoA dehydrogenase activity
D8668_RS26775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8668_RS26795	COG2706	6-phosphogluconolactonase activity
D8668_RS26805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8668_RS26810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS26920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8668_RS26920	COG2226	methyltransferase
D8668_RS26920	COG3433	isochorismatase activity
D8668_RS26935	COG1021	2,3-dihydroxybenzoate-AMP ligase
D8668_RS26960	COG2814	Major facilitator Superfamily
D8668_RS27085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D8668_RS27250	COG0739	heme binding
D8668_RS27280	COG1981	membrane
D8668_RS27305	COG0537	adenosine 5'-monophosphoramidase activity
D8668_RS27320	COG1765	OsmC-like protein
D8668_RS27355	COG3179	chitinase
D8668_RS27440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D8668_RS27465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D8668_RS27475	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8668_RS27485	COG3842	ATPase activity
D8668_RS27495	COG2197	response regulator
D8668_RS27510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D8668_RS27530	COG3344	reverse transcriptase
D8668_RS27570	COG2766	serine protein kinase
D8668_RS27580	COG2719	SpoVR family
D8668_RS27600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D8668_RS27640	COG3344	reverse transcriptase
D8668_RS27705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8668_RS27710	COG1917	Cupin 2, conserved barrel domain protein
D8668_RS27710	COG4977	sequence-specific DNA binding
D8668_RS27715	COG3152	Membrane
D8668_RS27720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8668_RS27725	COG1451	nucleotide metabolic process
D8668_RS27730	COG2081	HI0933 family
D8668_RS27770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D8668_RS27775	COG3622	Belongs to the hyi family
D8668_RS27785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D8668_RS27790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8668_RS27845	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D8668_RS27855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS27880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8668_RS27890	COG2258	MOSC domain
D8668_RS27895	COG0583	DNA-binding transcription factor activity
D8668_RS27900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8668_RS27985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D8668_RS27985	COG1648	precorrin-2 dehydrogenase activity
D8668_RS27995	COG1960	acyl-CoA dehydrogenase activity
D8668_RS28005	COG1960	acyl-CoA dehydrogenase activity
D8668_RS28010	COG1960	acyl-CoA dehydrogenase activity
D8668_RS28030	COG2226	methyltransferase
D8668_RS28030	COG1073	alpha beta
D8668_RS28050	COG1984	allophanate hydrolase subunit 2
D8668_RS28065	COG0511	ligase activity, forming carbon-carbon bonds
D8668_RS28090	COG5544	Lipoprotein
D8668_RS28095	COG2005	Transcriptional regulator
D8668_RS28095	COG3585	molybdate ion transport
D8668_RS28130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8668_RS28150	COG1953	Uracil, thiamine, allantoin
D8668_RS28155	COG1309	transcriptional regulator
D8668_RS28165	COG0625	glutathione transferase activity
D8668_RS28170	COG1595	DNA-templated transcription, initiation
D8668_RS28175	COG3712	iron ion homeostasis
D8668_RS28180	COG4774	siderophore transport
D8668_RS28215	COG4452	Inner membrane protein CreD
D8668_RS28220	COG2205	protein histidine kinase activity
D8668_RS28225	COG0745	RESPONSE REGULATOR receiver
D8668_RS28235	COG0204	Acyl-transferase
D8668_RS28245	COG0542	response to heat
D8668_RS28255	COG0477	Major facilitator Superfamily
D8668_RS28260	COG4067	protein conserved in archaea
D8668_RS28260	COG0189	ligase activity
D8668_RS28270	COG0513	Belongs to the DEAD box helicase family
D8668_RS28275	COG1289	transmembrane transporter activity
D8668_RS28285	COG0330	HflC and HflK could
D8668_RS28295	COG0306	phosphate transporter
D8668_RS28305	COG0583	DNA-binding transcription factor activity
D8668_RS28310	COG1960	acyl-CoA dehydrogenase activity
D8668_RS28325	COG1953	Uracil, thiamine, allantoin
D8668_RS28345	COG0493	'glutamate synthase
D8668_RS28360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D8668_RS28365	COG0402	S-adenosylhomocysteine deaminase activity
D8668_RS28370	COG1309	transcriptional regulator
D8668_RS28395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8668_RS28400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D8668_RS28440	COG3038	cytochrome b561
D8668_RS28460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8668_RS28555	COG0626	cystathionine gamma-synthase activity
D8668_RS28600	COG1872	DUF167
D8668_RS28605	COG1160	GTP binding
D8668_RS28615	COG2813	Specifically methylates the guanine in position
D8668_RS28615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8668_RS28630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8668_RS28665	COG2363	Small membrane protein
D8668_RS28685	COG2177	Part of the ABC transporter FtsEX involved in
D8668_RS28690	COG2884	Cell division ATP-binding protein ftsE
D8668_RS28695	COG0552	protein localization to endoplasmic reticulum
D8668_RS28700	COG0612	Peptidase, M16
D8668_RS28705	COG0612	Peptidase, M16
D8668_RS28710	COG0742	ribosomal rna small subunit methyltransferase
D8668_RS28720	COG0429	hydrolase of the alpha beta-hydrolase fold
D8668_RS28745	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D8668_RS28755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8668_RS28795	COG0693	protein deglycase activity
D8668_RS28810	COG2233	PERMEase
D8668_RS28815	COG0622	Phosphoesterase
D8668_RS28835	COG0584	glycerophosphoryl diester phosphodiesterase
D8668_RS28870	COG0730	response to heat
D8668_RS28880	COG3706	GGDEF domain
D8668_RS28920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8668_RS28940	COG2234	aminopeptidase activity
D8668_RS28945	COG3204	pilus organization
D8668_RS28965	COG1177	transmembrane transport
D8668_RS28970	COG2182	Extracellular solute-binding protein
D8668_RS28975	COG0531	amino acid
D8668_RS28985	COG3111	PFAM Bacterial OB fold (BOF) protein
D8668_RS28995	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8668_RS29000	COG0277	FAD linked oxidase domain protein
D8668_RS29005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8668_RS29020	COG0765	amino acid transport
D8668_RS29075	COG1177	transmembrane transport
D8668_RS29080	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8668_RS29085	COG3842	ATPase activity
D8668_RS29105	COG0174	glutamine synthetase
D8668_RS29110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D8668_RS29115	COG0174	glutamine synthetase
D8668_RS29120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D8668_RS29145	COG2199	diguanylate cyclase activity
D8668_RS29180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D8668_RS29190	COG4208	sulfate ABC transporter
D8668_RS29210	COG0501	Belongs to the peptidase M48B family
D8668_RS29235	COG0583	DNA-binding transcription factor activity
D8668_RS29250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8668_RS29260	COG0745	RESPONSE REGULATOR receiver
D8668_RS29305	COG0582	viral genome integration into host DNA
D8668_RS29365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8668_RS29375	COG0583	DNA-binding transcription factor activity
D8668_RS29390	COG0210	DNA helicase
D8668_RS29395	COG0028	Belongs to the TPP enzyme family
D8668_RS29405	COG0427	acetyl-CoA hydrolase
D8668_RS29415	COG1917	Cupin 2, conserved barrel domain protein
D8668_RS29415	COG1396	sequence-specific DNA binding
D8668_RS29425	COG0251	oxidation-reduction process
D8668_RS29455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8668_RS29460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8668_RS29465	COG2814	Major facilitator Superfamily
D8668_RS29470	COG1012	belongs to the aldehyde dehydrogenase family
D8668_RS29475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8668_RS29495	COG0747	negative chemotaxis
D8668_RS29510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D8668_RS29550	COG3245	cytochrome
D8668_RS29570	COG0708	Exodeoxyribonuclease III
D8668_RS29585	COG1561	YicC-like family, N-terminal region
D8668_RS29600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8668_RS29630	COG0583	DNA-binding transcription factor activity
D8668_RS29635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D8668_RS29675	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D8668_RS29680	COG0247	lactate metabolic process
D8668_RS29685	COG0277	FAD linked oxidase domain protein
D8668_RS29690	COG0277	FAD linked oxidase domain protein
D8668_RS29725	COG1253	flavin adenine dinucleotide binding
D8668_RS29730	COG0739	heme binding
D8668_RS29750	COG0573	inorganic phosphate transmembrane transporter activity
D8668_RS29790	COG0477	Major facilitator Superfamily
D8668_RS29795	COG1607	acyl-coa hydrolase
D8668_RS29820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8668_RS29825	COG4175	Glycine betaine
D8668_RS29830	COG4176	ABC-type proline glycine betaine transport system permease component
D8668_RS29840	COG1760	l-serine dehydratase
D8668_RS29855	COG0583	DNA-binding transcription factor activity
D8668_RS29865	COG0657	acetylesterase activity
D8668_RS29880	COG3246	L-lysine catabolic process to acetate
D8668_RS29935	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8668_RS29935	COG1902	pentaerythritol trinitrate reductase activity
D8668_RS29940	COG2181	nitrate reductase activity
D8668_RS29940	COG0247	lactate metabolic process
D8668_RS29945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D8668_RS29960	COG3655	Transcriptional regulator
D8668_RS30000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8668_RS30000	COG1017	nitric oxide dioxygenase activity
D8668_RS30090	COG0583	DNA-binding transcription factor activity
D8668_RS30105	COG2391	methyltransferase activity
D8668_RS30130	COG5016	pyruvate
D8668_RS30130	COG0511	ligase activity, forming carbon-carbon bonds
D8668_RS30135	COG0439	Biotin carboxylase
D8668_RS30140	COG0583	DNA-binding transcription factor activity
D8668_RS30155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D8668_RS30160	COG0826	peptidase U32
D8668_RS30180	COG0210	DNA helicase
D8668_RS30190	COG0427	acetyl-CoA hydrolase
D8668_RS30205	COG0438	transferase activity, transferring glycosyl groups
D8668_RS30250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8668_RS30255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D8668_RS30255	COG2755	lipolytic protein G-D-S-L family
D8668_RS30295	COG0679	Auxin Efflux Carrier
D8668_RS30305	COG2851	Citrate transporter
D8668_RS30310	COG0861	Integral membrane protein TerC family
D8668_RS30315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D8668_RS30320	COG1690	Belongs to the RtcB family
D8668_RS30365	COG0700	Nucleoside recognition
D8668_RS30370	COG1301	dicarboxylic acid transport
D8668_RS30395	COG5002	protein histidine kinase activity
D8668_RS30400	COG3023	N-Acetylmuramoyl-L-alanine amidase
D8668_RS30405	COG2095	MarC family integral membrane protein
D8668_RS30430	COG3245	cytochrome
D8668_RS30465	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D8668_RS30470	COG0735	belongs to the Fur family
D8668_RS30480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D8668_RS30495	COG2011	ABC-type metal ion transport system permease component
D8668_RS30525	COG0531	amino acid
D8668_RS30535	COG4191	Histidine kinase
D8668_RS30565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8668_RS30565	COG4651	solute:proton antiporter activity
D8668_RS30570	COG1607	acyl-coa hydrolase
D8668_RS30580	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS30585	COG0174	glutamine synthetase
D8668_RS30590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8668_RS30595	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS30625	COG4651	solute:proton antiporter activity
D8668_RS30625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8668_RS30630	COG0477	Major facilitator Superfamily
D8668_RS30640	COG0523	cobalamin synthesis protein
D8668_RS30675	COG0789	Transcriptional regulator
D8668_RS30685	COG2608	mercury ion transmembrane transporter activity
D8668_RS30695	COG0789	Transcriptional regulator
D8668_RS30710	COG0659	secondary active sulfate transmembrane transporter activity
D8668_RS30715	COG0589	response to stress
D8668_RS30740	COG2050	protein possibly involved in aromatic compounds catabolism
D8668_RS30765	COG4974	Belongs to the 'phage' integrase family
D8668_RS30855	COG1061	Type III restriction enzyme res subunit
D8668_RS30880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D8668_RS30900	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D8668_RS30905	COG0339	signal peptide processing
D8668_RS30910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D8668_RS30945	COG1764	response to oxidative stress
D8668_RS30960	COG0583	DNA-binding transcription factor activity
D8668_RS30980	COG0367	asparagine synthase
D8668_RS31020	COG3174	membrane
D8668_RS31120	COG3360	Dodecin
D8668_RS31155	COG0583	DNA-binding transcription factor activity
D8668_RS31160	COG3119	arylsulfatase activity
D8668_RS31180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8668_RS31210	COG0758	DNA mediated transformation
D8668_RS31215	COG1652	LysM domain
D8668_RS31235	COG0569	domain protein
D8668_RS31250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D8668_RS31265	COG2818	Glycosylase
D8668_RS31280	COG2010	Cytochrome c
D8668_RS31395	COG0582	viral genome integration into host DNA
D8668_RS31465	COG1192	Involved in chromosome partitioning
D8668_RS31470	COG1475	DNA binding
D8668_RS31530	COG1349	DNA-binding transcription factor activity
D8668_RS31550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D8668_RS31555	COG2358	TRAP transporter, solute receptor (TAXI family
D8668_RS31575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D8668_RS31600	COG4644	lycopene metabolic process
D8668_RS31605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D8668_RS31650	COG3547	Transposase (IS116 IS110 IS902 family)
D8668_RS31850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D8668_RS31870	COG0631	protein serine/threonine phosphatase activity
D8668_RS31885	COG1360	Flagellar Motor Protein
D8668_RS32015	COG0659	secondary active sulfate transmembrane transporter activity
D8668_RS32030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D8668_RS32035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8668_RS32040	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D8668_RS32080	COG2153	protein acetylation
D8668_RS32120	COG0583	DNA-binding transcription factor activity
D8668_RS32145	COG2824	Alkylphosphonate utilization operon protein PhnA
D8668_RS32175	COG0402	S-adenosylhomocysteine deaminase activity
D8668_RS32185	COG3845	ABC transporter
D8668_RS32195	COG1079	Belongs to the binding-protein-dependent transport system permease family
D8668_RS32275	COG0583	DNA-binding transcription factor activity
D8668_RS32280	COG3485	protocatechuate 3,4-dioxygenase
D8668_RS32285	COG3485	protocatechuate 3,4-dioxygenase
D8668_RS32295	COG1414	Transcriptional regulator
D8668_RS32310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8668_RS32315	COG0583	DNA-binding transcription factor activity
D8668_RS32350	COG2233	PERMEase
D8668_RS32355	COG1309	transcriptional regulator
D8668_RS32390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D8668_RS32405	COG0835	chemotaxis
D8668_RS32415	COG0745	RESPONSE REGULATOR receiver
D8668_RS32425	COG0583	DNA-binding transcription factor activity
D8668_RS32430	COG1028	Short-chain dehydrogenase reductase Sdr
D8668_RS32440	COG1116	anion transmembrane transporter activity
D8668_RS32450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8668_RS32485	COG2175	clavaminate synthase activity