locus-tag	class	description
HV99_RS00035	COG1307	EDD domain protein, DegV family
HV99_RS00045	COG1309	transcriptional regulator
HV99_RS00050	COG0386	Belongs to the glutathione peroxidase family
HV99_RS00070	COG0204	Acyl-transferase
HV99_RS00075	COG2885	chlorophyll binding
HV99_RS00080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV99_RS00095	COG2267	carboxylic ester hydrolase activity
HV99_RS00145	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HV99_RS00180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV99_RS00195	COG0546	phosphoglycolate phosphatase activity
HV99_RS00210	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV99_RS00225	COG0656	L-ascorbic acid biosynthetic process
HV99_RS00250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV99_RS00260	COG1802	Transcriptional regulator
HV99_RS00270	COG0372	Belongs to the citrate synthase family
HV99_RS00285	COG2079	MmgE PrpD family protein
HV99_RS00300	COG1113	amino acid transport
HV99_RS00330	COG0583	DNA-binding transcription factor activity
HV99_RS00335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV99_RS00345	COG4206	TonB-dependent receptor
HV99_RS00355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV99_RS00420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV99_RS00500	COG3180	Ammonia monooxygenase
HV99_RS00510	COG2720	vancomycin resistance protein
HV99_RS00525	COG1960	acyl-CoA dehydrogenase activity
HV99_RS00530	COG1024	Enoyl-CoA hydratase
HV99_RS00550	COG2910	NAD(P)H-binding
HV99_RS00555	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV99_RS00670	COG0463	Glycosyl transferase, family 2
HV99_RS00675	COG0154	amidase activity
HV99_RS00695	COG0583	DNA-binding transcription factor activity
HV99_RS00705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV99_RS00740	COG2831	hemolysin activation secretion protein
HV99_RS00890	COG0420	3'-5' exonuclease activity
HV99_RS00900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV99_RS00905	COG1074	ATP-dependent DNA helicase activity
HV99_RS00910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV99_RS00915	COG0095	Lipoate-protein ligase
HV99_RS00920	COG0697	spore germination
HV99_RS00935	COG0840	transmembrane signaling receptor activity
HV99_RS00945	COG0306	phosphate transporter
HV99_RS01005	COG4964	Belongs to the GSP D family
HV99_RS01025	COG0433	COG0433 Predicted ATPase
HV99_RS01060	COG0788	formyltetrahydrofolate deformylase activity
HV99_RS01070	COG2925	Exonuclease
HV99_RS01100	COG0714	Associated with various cellular activities
HV99_RS01130	COG0589	response to stress
HV99_RS01140	COG1024	Enoyl-CoA hydratase
HV99_RS01150	COG3706	GGDEF domain
HV99_RS01170	COG0693	protein deglycase activity
HV99_RS01185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV99_RS01200	COG0154	amidase activity
HV99_RS01210	COG1473	amidohydrolase
HV99_RS01225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV99_RS01230	COG0426	domain, Protein
HV99_RS01230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV99_RS01250	COG0589	response to stress
HV99_RS01265	COG2814	Major facilitator Superfamily
HV99_RS01270	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS01285	COG1918	ferrous iron import across plasma membrane
HV99_RS01300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV99_RS01340	COG1704	LemA family
HV99_RS01365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS01370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS01385	COG3642	lipopolysaccharide core region biosynthetic process
HV99_RS01395	COG2205	protein histidine kinase activity
HV99_RS01400	COG0745	RESPONSE REGULATOR receiver
HV99_RS01435	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV99_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS01470	COG0668	transmembrane transport
HV99_RS01480	COG0745	RESPONSE REGULATOR receiver
HV99_RS01495	COG2096	Adenosyltransferase
HV99_RS01500	COG0494	nUDIX hydrolase
HV99_RS01520	COG0739	heme binding
HV99_RS01520	COG0741	lytic transglycosylase activity
HV99_RS01520	COG1196	nuclear chromosome segregation
HV99_RS01565	COG0772	Belongs to the SEDS family
HV99_RS01580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV99_RS01620	COG3107	peptidoglycan biosynthetic process
HV99_RS01635	COG2823	Periplasmic or secreted lipoprotein
HV99_RS01640	COG2969	positive regulation of protein catabolic process
HV99_RS01645	COG0625	glutathione transferase activity
HV99_RS01650	COG2857	Cytochrome c1
HV99_RS01655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV99_RS01660	COG0723	plastoquinol--plastocyanin reductase activity
HV99_RS01675	COG0667	Aldo Keto reductase
HV99_RS01680	COG1960	acyl-CoA dehydrogenase activity
HV99_RS01695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV99_RS01705	COG2945	thiolester hydrolase activity
HV99_RS01725	COG2951	lytic endotransglycosylase activity
HV99_RS01735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV99_RS01775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV99_RS01780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV99_RS01785	COG1127	ABC transporter
HV99_RS01795	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV99_RS01810	COG1137	ATPase activity
HV99_RS01865	COG0312	modulator of DNA gyrase
HV99_RS01875	COG0312	modulator of DNA gyrase
HV99_RS01880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV99_RS01890	COG1530	ribonuclease E activity
HV99_RS01905	COG1792	Involved in formation and maintenance of cell shape
HV99_RS01910	COG1077	Cell shape determining protein MreB Mrl
HV99_RS01930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV99_RS01935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV99_RS01940	COG4676	Protein conserved in bacteria
HV99_RS01945	COG5445	Predicted secreted protein (DUF2300)
HV99_RS01960	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HV99_RS01965	COG4676	Protein conserved in bacteria
HV99_RS01970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HV99_RS01985	COG0747	negative chemotaxis
HV99_RS01990	COG0747	negative chemotaxis
HV99_RS02080	COG1252	NADH dehydrogenase
HV99_RS02085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV99_RS02090	COG2831	hemolysin activation secretion protein
HV99_RS02160	COG4969	Belongs to the N-Me-Phe pilin family
HV99_RS02200	COG1047	Peptidyl-prolyl cis-trans
HV99_RS02215	COG0196	riboflavin kinase activity
HV99_RS02230	COG3045	CreA protein
HV99_RS02255	COG0142	geranyltranstransferase activity
HV99_RS02270	COG0545	Peptidyl-prolyl cis-trans isomerase
HV99_RS02290	COG1067	ATP-dependent peptidase activity
HV99_RS02315	COG4650	regulator
HV99_RS02330	COG1690	Belongs to the RtcB family
HV99_RS02335	COG3541	Predicted nucleotidyltransferase
HV99_RS02355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV99_RS02380	COG0577	efflux transmembrane transporter activity
HV99_RS02380	COG1136	(ABC) transporter
HV99_RS02385	COG0577	efflux transmembrane transporter activity
HV99_RS02385	COG1136	(ABC) transporter
HV99_RS02390	COG0488	(ABC) transporter
HV99_RS02410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS02415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS02440	COG0523	cobalamin synthesis protein
HV99_RS02445	COG2879	small protein
HV99_RS02450	COG1966	Carbon starvation protein
HV99_RS02520	COG3608	succinylglutamate desuccinylase aspartoacylase
HV99_RS02520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HV99_RS02525	COG2010	Cytochrome c
HV99_RS02560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV99_RS02570	COG0833	amino acid
HV99_RS02575	COG2119	membrane
HV99_RS02590	COG0501	Belongs to the peptidase M48B family
HV99_RS02595	COG0840	transmembrane signaling receptor activity
HV99_RS02600	COG2135	peptidase activity
HV99_RS02605	COG1285	pathogenesis
HV99_RS02665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV99_RS02720	COG1090	epimerase
HV99_RS02725	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HV99_RS02735	COG0789	Transcriptional regulator
HV99_RS02755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV99_RS02810	COG0012	GTP binding
HV99_RS02820	COG4974	Belongs to the 'phage' integrase family
HV99_RS02830	COG4128	Pfam Zonular occludens toxin
HV99_RS02905	COG0288	reversible hydration of carbon dioxide
HV99_RS02915	COG0456	acetyltransferase
HV99_RS02960	COG1840	ABC-type Fe3 transport system, periplasmic component
HV99_RS02965	COG1178	ABC-type Fe3 transport system permease component
HV99_RS02970	COG3008	intermembrane lipid transfer
HV99_RS02975	COG2995	paraquat-inducible protein a
HV99_RS02980	COG2995	paraquat-inducible protein a
HV99_RS03020	COG1183	phosphatidylcholine synthase activity
HV99_RS03035	COG0028	Belongs to the TPP enzyme family
HV99_RS03045	COG3098	single-species biofilm formation
HV99_RS03055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV99_RS03090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV99_RS03095	COG4558	Periplasmic binding protein
HV99_RS03100	COG3720	iron ion transport
HV99_RS03130	COG0436	Aminotransferase
HV99_RS03140	COG2321	neutral zinc metallopeptidase
HV99_RS03150	COG2252	PERMEase
HV99_RS03165	COG0436	Aminotransferase
HV99_RS03170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV99_RS03185	COG4191	Histidine kinase
HV99_RS03285	COG0195	Participates in both transcription termination and antitermination
HV99_RS03320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV99_RS03385	COG0497	DNA recombination
HV99_RS03415	COG2186	Transcriptional regulator
HV99_RS03420	COG1620	l-lactate permease
HV99_RS03470	COG0697	spore germination
HV99_RS03490	COG0697	spore germination
HV99_RS03495	COG1522	sequence-specific DNA binding
HV99_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS03525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV99_RS03555	COG0509	glycine decarboxylation via glycine cleavage system
HV99_RS03595	COG0531	amino acid
HV99_RS03610	COG3276	selenocysteine insertion sequence binding
HV99_RS03625	COG2864	formate dehydrogenase
HV99_RS03630	COG0437	4 iron, 4 sulfur cluster binding
HV99_RS03635	COG0243	molybdopterin cofactor binding
HV99_RS03635	COG3383	formate dehydrogenase (NAD+) activity
HV99_RS03640	COG0243	molybdopterin cofactor binding
HV99_RS03640	COG3383	formate dehydrogenase (NAD+) activity
HV99_RS03645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HV99_RS03650	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS03650	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV99_RS03675	COG0463	Glycosyl transferase, family 2
HV99_RS03685	COG0534	Mate efflux family protein
HV99_RS03695	COG1283	sodium-dependent phosphate transmembrane transporter activity
HV99_RS03720	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV99_RS03745	COG4221	oxidoreductase activity
HV99_RS03750	COG1272	protein, Hemolysin III
HV99_RS03785	COG0023	Translation Initiation Factor
HV99_RS03870	COG2095	MarC family integral membrane protein
HV99_RS03875	COG0683	leucine binding
HV99_RS03890	COG0411	ABC transporter
HV99_RS03935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV99_RS03950	COG0443	Heat shock 70 kDa protein
HV99_RS03975	COG0789	Transcriptional regulator
HV99_RS03980	COG2982	Protein involved in outer membrane biogenesis
HV99_RS03985	COG2193	ferroxidase activity
HV99_RS03995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HV99_RS04000	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV99_RS04060	COG3712	iron ion homeostasis
HV99_RS04065	COG1595	DNA-templated transcription, initiation
HV99_RS04085	COG2814	Major facilitator Superfamily
HV99_RS04095	COG0583	DNA-binding transcription factor activity
HV99_RS04120	COG4221	oxidoreductase activity
HV99_RS04125	COG2423	ornithine cyclodeaminase activity
HV99_RS04155	COG0583	DNA-binding transcription factor activity
HV99_RS04170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HV99_RS04210	COG0668	transmembrane transport
HV99_RS04230	COG5001	Diguanylate cyclase
HV99_RS04230	COG3300	MHYT domain
HV99_RS04240	COG0305	Participates in initiation and elongation during chromosome replication
HV99_RS04270	COG0557	exoribonuclease II activity
HV99_RS04300	COG0330	HflC and HflK could
HV99_RS04305	COG0330	HflC and HflK could
HV99_RS04310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV99_RS04330	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV99_RS04340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV99_RS04340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV99_RS04390	COG3300	MHYT domain
HV99_RS04390	COG5001	Diguanylate cyclase
HV99_RS04395	COG0560	Phosphoserine phosphatase
HV99_RS04395	COG3830	Belongs to the UPF0237 family
HV99_RS04405	COG1988	membrane-bound metal-dependent
HV99_RS04420	COG3577	Aspartyl protease
HV99_RS04435	COG3150	esterase
HV99_RS04440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV99_RS04450	COG0494	nUDIX hydrolase
HV99_RS04465	COG1538	Outer membrane efflux protein
HV99_RS04470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV99_RS04485	COG0045	succinate-CoA ligase (ADP-forming) activity
HV99_RS04490	COG1960	acyl-CoA dehydrogenase activity
HV99_RS04495	COG1024	Enoyl-CoA hydratase
HV99_RS04500	COG0833	amino acid
HV99_RS04530	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS04530	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV99_RS04540	COG1519	Transferase
HV99_RS04545	COG0583	DNA-binding transcription factor activity
HV99_RS04560	COG0667	Aldo Keto reductase
HV99_RS04570	COG1960	acyl-CoA dehydrogenase activity
HV99_RS04575	COG1960	acyl-CoA dehydrogenase activity
HV99_RS04590	COG0367	asparagine synthase
HV99_RS04615	COG1215	transferase activity, transferring glycosyl groups
HV99_RS04635	COG0438	transferase activity, transferring glycosyl groups
HV99_RS04640	COG2192	nodulation
HV99_RS04665	COG0438	transferase activity, transferring glycosyl groups
HV99_RS04670	COG0859	PFAM glycosyl transferase family 9
HV99_RS04675	COG0859	PFAM glycosyl transferase family 9
HV99_RS04710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV99_RS04715	COG1960	acyl-CoA dehydrogenase activity
HV99_RS04725	COG1196	nuclear chromosome segregation
HV99_RS04725	COG3264	Mechanosensitive ion channel
HV99_RS04735	COG0730	response to heat
HV99_RS04740	COG2873	o-acetylhomoserine
HV99_RS04755	COG1192	Involved in chromosome partitioning
HV99_RS04760	COG0583	DNA-binding transcription factor activity
HV99_RS04765	COG2814	Major facilitator Superfamily
HV99_RS04790	COG0493	'glutamate synthase
HV99_RS04795	COG0069	glutamate synthase activity
HV99_RS04795	COG0070	glutamate synthase
HV99_RS04795	COG0067	glutamate synthase
HV99_RS04845	COG0281	malic enzyme
HV99_RS04865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV99_RS04975	COG0840	transmembrane signaling receptor activity
HV99_RS04985	COG1126	abc transporter atp-binding protein
HV99_RS04990	COG0765	amino acid transport
HV99_RS05020	COG1051	belongs to the nudix hydrolase family
HV99_RS05025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS05030	COG0251	oxidation-reduction process
HV99_RS05055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV99_RS05075	COG2986	histidine ammonia-lyase
HV99_RS05080	COG4175	Glycine betaine
HV99_RS05085	COG4176	ABC-type proline glycine betaine transport system permease component
HV99_RS05105	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV99_RS05140	COG0402	S-adenosylhomocysteine deaminase activity
HV99_RS05190	COG0789	Transcriptional regulator
HV99_RS05195	COG1217	gtp-binding protein TYPA
HV99_RS05215	COG0668	transmembrane transport
HV99_RS05230	COG3852	Histidine kinase
HV99_RS05245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV99_RS05275	COG4942	peptidase
HV99_RS05280	COG0793	Belongs to the peptidase S41A family
HV99_RS05285	COG2861	carbohydrate metabolic process
HV99_RS05345	COG0579	oxidoreductase
HV99_RS05355	COG1194	a g-specific adenine glycosylase
HV99_RS05365	COG0673	inositol 2-dehydrogenase activity
HV99_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS05420	COG1566	PFAM secretion protein HlyD family protein
HV99_RS05425	COG2814	Major facilitator Superfamily
HV99_RS05435	COG1088	dTDP-glucose 4,6-dehydratase activity
HV99_RS05440	COG1091	dTDP-4-dehydrorhamnose reductase activity
HV99_RS05505	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV99_RS05510	COG0494	nUDIX hydrolase
HV99_RS05515	COG1011	Hydrolase
HV99_RS05520	COG1652	LysM domain
HV99_RS05530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HV99_RS05550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV99_RS05560	COG0824	Thioesterase
HV99_RS05565	COG1454	alcohol dehydrogenase
HV99_RS05570	COG1960	acyl-CoA dehydrogenase activity
HV99_RS05575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV99_RS05575	COG1024	Enoyl-CoA hydratase
HV99_RS05585	COG0778	Nitroreductase
HV99_RS05610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV99_RS05615	COG0189	ligase activity
HV99_RS05615	COG4067	protein conserved in archaea
HV99_RS05640	COG2183	response to ionizing radiation
HV99_RS05670	COG0306	phosphate transporter
HV99_RS05675	COG1392	Phosphate transport regulator
HV99_RS05680	COG3025	triphosphatase activity
HV99_RS05685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV99_RS05715	COG1178	ABC-type Fe3 transport system permease component
HV99_RS05725	COG0583	DNA-binding transcription factor activity
HV99_RS05740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV99_RS05750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV99_RS05755	COG0006	proline dipeptidase activity
HV99_RS05780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV99_RS05790	COG0842	Transport permease protein
HV99_RS05795	COG0842	Transport permease protein
HV99_RS05795	COG1129	ABC transporter
HV99_RS05800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS05815	COG2271	Major facilitator Superfamily
HV99_RS05830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HV99_RS05830	COG2755	lipolytic protein G-D-S-L family
HV99_RS05860	COG0586	Pfam SNARE associated Golgi protein
HV99_RS05865	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV99_RS05870	COG2050	protein possibly involved in aromatic compounds catabolism
HV99_RS05880	COG0672	)-iron permease
HV99_RS05885	COG1280	lysine exporter protein (LysE YggA)
HV99_RS05890	COG0861	Integral membrane protein TerC family
HV99_RS05900	COG0488	(ABC) transporter
HV99_RS05955	COG3275	phosphorelay sensor kinase activity
HV99_RS05985	COG0598	Magnesium transport protein CorA
HV99_RS06015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV99_RS06075	COG0432	Pfam Uncharacterised protein family UPF0047
HV99_RS06080	COG0004	ammonium transporteR
HV99_RS06085	COG0347	Belongs to the P(II) protein family
HV99_RS06095	COG0606	chelatase, subunit chli
HV99_RS06100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV99_RS06110	COG0583	DNA-binding transcription factor activity
HV99_RS06125	COG0210	DNA helicase
HV99_RS06130	COG0028	Belongs to the TPP enzyme family
HV99_RS06140	COG0427	acetyl-CoA hydrolase
HV99_RS06150	COG1917	Cupin 2, conserved barrel domain protein
HV99_RS06150	COG1396	sequence-specific DNA binding
HV99_RS06160	COG0251	oxidation-reduction process
HV99_RS06190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS06195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV99_RS06200	COG2814	Major facilitator Superfamily
HV99_RS06205	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS06210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV99_RS06230	COG0747	negative chemotaxis
HV99_RS06245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV99_RS06285	COG3245	cytochrome
HV99_RS06305	COG0708	Exodeoxyribonuclease III
HV99_RS06320	COG1561	YicC-like family, N-terminal region
HV99_RS06335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV99_RS06355	COG2207	Transcriptional regulator
HV99_RS06355	COG4753	response regulator
HV99_RS06365	COG0583	DNA-binding transcription factor activity
HV99_RS06370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV99_RS06405	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HV99_RS06410	COG0247	lactate metabolic process
HV99_RS06415	COG0277	FAD linked oxidase domain protein
HV99_RS06420	COG0277	FAD linked oxidase domain protein
HV99_RS06425	COG2186	Transcriptional regulator
HV99_RS06455	COG1253	flavin adenine dinucleotide binding
HV99_RS06460	COG0739	heme binding
HV99_RS06480	COG0573	inorganic phosphate transmembrane transporter activity
HV99_RS06520	COG0477	Major facilitator Superfamily
HV99_RS06525	COG1607	acyl-coa hydrolase
HV99_RS06545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV99_RS06550	COG4175	Glycine betaine
HV99_RS06555	COG4176	ABC-type proline glycine betaine transport system permease component
HV99_RS06565	COG1760	l-serine dehydratase
HV99_RS06580	COG0583	DNA-binding transcription factor activity
HV99_RS06590	COG0657	acetylesterase activity
HV99_RS06605	COG3246	L-lysine catabolic process to acetate
HV99_RS06660	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS06660	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV99_RS06665	COG2181	nitrate reductase activity
HV99_RS06665	COG0247	lactate metabolic process
HV99_RS06685	COG3655	Transcriptional regulator
HV99_RS06725	COG1017	nitric oxide dioxygenase activity
HV99_RS06725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV99_RS06810	COG0583	DNA-binding transcription factor activity
HV99_RS06820	COG2391	methyltransferase activity
HV99_RS06845	COG5016	pyruvate
HV99_RS06845	COG0511	ligase activity, forming carbon-carbon bonds
HV99_RS06850	COG0439	Biotin carboxylase
HV99_RS06855	COG0583	DNA-binding transcription factor activity
HV99_RS06870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV99_RS06875	COG0826	peptidase U32
HV99_RS06895	COG0210	DNA helicase
HV99_RS06905	COG0427	acetyl-CoA hydrolase
HV99_RS06920	COG0438	transferase activity, transferring glycosyl groups
HV99_RS06965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV99_RS06970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HV99_RS06970	COG2755	lipolytic protein G-D-S-L family
HV99_RS07010	COG0679	Auxin Efflux Carrier
HV99_RS07020	COG2851	Citrate transporter
HV99_RS07025	COG0861	Integral membrane protein TerC family
HV99_RS07030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV99_RS07035	COG1690	Belongs to the RtcB family
HV99_RS07070	COG0700	Nucleoside recognition
HV99_RS07075	COG1301	dicarboxylic acid transport
HV99_RS07100	COG5002	protein histidine kinase activity
HV99_RS07105	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV99_RS07110	COG2095	MarC family integral membrane protein
HV99_RS07170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV99_RS07175	COG0735	belongs to the Fur family
HV99_RS07185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV99_RS07200	COG2011	ABC-type metal ion transport system permease component
HV99_RS07230	COG0531	amino acid
HV99_RS07240	COG4191	Histidine kinase
HV99_RS07275	COG4651	solute:proton antiporter activity
HV99_RS07275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV99_RS07280	COG1607	acyl-coa hydrolase
HV99_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS07295	COG0174	glutamine synthetase
HV99_RS07300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HV99_RS07305	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS07330	COG4651	solute:proton antiporter activity
HV99_RS07330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV99_RS07335	COG0477	Major facilitator Superfamily
HV99_RS07345	COG0523	cobalamin synthesis protein
HV99_RS07390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HV99_RS07410	COG2358	TRAP transporter, solute receptor (TAXI family
HV99_RS07415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV99_RS07470	COG1349	DNA-binding transcription factor activity
HV99_RS07530	COG1475	DNA binding
HV99_RS07535	COG1192	Involved in chromosome partitioning
HV99_RS07605	COG2010	Cytochrome c
HV99_RS07620	COG2818	Glycosylase
HV99_RS07635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV99_RS07650	COG0569	domain protein
HV99_RS07670	COG1652	LysM domain
HV99_RS07675	COG0758	DNA mediated transformation
HV99_RS07705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV99_RS07725	COG3119	arylsulfatase activity
HV99_RS07730	COG0583	DNA-binding transcription factor activity
HV99_RS07765	COG3360	Dodecin
HV99_RS07780	COG3210	domain, Protein
HV99_RS07800	COG3174	membrane
HV99_RS07840	COG0367	asparagine synthase
HV99_RS07860	COG0583	DNA-binding transcription factor activity
HV99_RS07875	COG1764	response to oxidative stress
HV99_RS07910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV99_RS07915	COG0339	signal peptide processing
HV99_RS07920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV99_RS07935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV99_RS07950	COG2815	serine threonine protein kinase
HV99_RS07950	COG0515	serine threonine protein kinase
HV99_RS07955	COG0631	protein serine/threonine phosphatase activity
HV99_RS07970	COG1360	Flagellar Motor Protein
HV99_RS08095	COG0659	secondary active sulfate transmembrane transporter activity
HV99_RS08105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV99_RS08110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV99_RS08115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HV99_RS08155	COG2153	protein acetylation
HV99_RS08195	COG0583	DNA-binding transcription factor activity
HV99_RS08220	COG2824	Alkylphosphonate utilization operon protein PhnA
HV99_RS08250	COG0402	S-adenosylhomocysteine deaminase activity
HV99_RS08260	COG3845	ABC transporter
HV99_RS08265	COG4603	Belongs to the binding-protein-dependent transport system permease family
HV99_RS08270	COG1079	Belongs to the binding-protein-dependent transport system permease family
HV99_RS08340	COG0583	DNA-binding transcription factor activity
HV99_RS08350	COG3485	protocatechuate 3,4-dioxygenase
HV99_RS08355	COG1414	Transcriptional regulator
HV99_RS08370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS08375	COG0583	DNA-binding transcription factor activity
HV99_RS08410	COG2233	PERMEase
HV99_RS08415	COG1309	transcriptional regulator
HV99_RS08450	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HV99_RS08465	COG0835	chemotaxis
HV99_RS08470	COG2198	Histidine kinase
HV99_RS08470	COG0643	Histidine kinase
HV99_RS08475	COG0745	RESPONSE REGULATOR receiver
HV99_RS08485	COG0583	DNA-binding transcription factor activity
HV99_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS08500	COG1116	anion transmembrane transporter activity
HV99_RS08505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS08510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS08550	COG2175	clavaminate synthase activity
HV99_RS08625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV99_RS08655	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS08660	COG1113	amino acid transport
HV99_RS08675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV99_RS08680	COG0235	Class ii aldolase
HV99_RS08685	COG1396	sequence-specific DNA binding
HV99_RS08690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV99_RS08695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV99_RS08705	COG0477	Major facilitator Superfamily
HV99_RS08715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV99_RS08720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV99_RS08725	COG0583	DNA-binding transcription factor activity
HV99_RS08745	COG0673	inositol 2-dehydrogenase activity
HV99_RS08765	COG2271	Major facilitator Superfamily
HV99_RS08775	COG1309	transcriptional regulator
HV99_RS08780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV99_RS08790	COG0477	Major facilitator Superfamily
HV99_RS08810	COG2239	Acts as a magnesium transporter
HV99_RS08850	COG2801	Transposase and inactivated derivatives
HV99_RS08885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV99_RS08895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV99_RS08940	COG0745	RESPONSE REGULATOR receiver
HV99_RS08950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV99_RS08965	COG0583	DNA-binding transcription factor activity
HV99_RS08970	COG2807	transmembrane transport
HV99_RS08990	COG0501	Belongs to the peptidase M48B family
HV99_RS09010	COG4208	sulfate ABC transporter
HV99_RS09020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV99_RS09055	COG2199	diguanylate cyclase activity
HV99_RS09080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV99_RS09085	COG0174	glutamine synthetase
HV99_RS09090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV99_RS09095	COG0174	glutamine synthetase
HV99_RS09115	COG3842	ATPase activity
HV99_RS09120	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV99_RS09125	COG1177	transmembrane transport
HV99_RS09175	COG0765	amino acid transport
HV99_RS09190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV99_RS09195	COG0277	FAD linked oxidase domain protein
HV99_RS09200	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV99_RS09210	COG3111	PFAM Bacterial OB fold (BOF) protein
HV99_RS09220	COG0531	amino acid
HV99_RS09225	COG2182	Extracellular solute-binding protein
HV99_RS09230	COG1177	transmembrane transport
HV99_RS09240	COG3842	ATPase activity
HV99_RS09245	COG3204	pilus organization
HV99_RS09250	COG2234	aminopeptidase activity
HV99_RS09265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV99_RS09275	COG0702	epimerase
HV99_RS09315	COG0730	response to heat
HV99_RS09350	COG0584	glycerophosphoryl diester phosphodiesterase
HV99_RS09370	COG0622	Phosphoesterase
HV99_RS09375	COG2233	PERMEase
HV99_RS09390	COG0693	protein deglycase activity
HV99_RS09425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV99_RS09435	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HV99_RS09460	COG0429	hydrolase of the alpha beta-hydrolase fold
HV99_RS09470	COG0742	ribosomal rna small subunit methyltransferase
HV99_RS09480	COG0612	Peptidase, M16
HV99_RS09485	COG0552	protein localization to endoplasmic reticulum
HV99_RS09490	COG2884	Cell division ATP-binding protein ftsE
HV99_RS09495	COG2177	Part of the ABC transporter FtsEX involved in
HV99_RS09515	COG2363	Small membrane protein
HV99_RS09550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV99_RS09565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV99_RS09565	COG2813	Specifically methylates the guanine in position
HV99_RS09575	COG1160	GTP binding
HV99_RS09580	COG1872	DUF167
HV99_RS09625	COG0626	cystathionine gamma-synthase activity
HV99_RS09720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV99_RS09735	COG3038	cytochrome b561
HV99_RS09765	COG0513	Belongs to the DEAD box helicase family
HV99_RS09775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV99_RS09780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV99_RS09805	COG1309	transcriptional regulator
HV99_RS09810	COG0402	S-adenosylhomocysteine deaminase activity
HV99_RS09815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV99_RS09825	COG0493	'glutamate synthase
HV99_RS09840	COG1953	Uracil, thiamine, allantoin
HV99_RS09855	COG1960	acyl-CoA dehydrogenase activity
HV99_RS09860	COG0583	DNA-binding transcription factor activity
HV99_RS09880	COG0330	HflC and HflK could
HV99_RS09890	COG1289	transmembrane transporter activity
HV99_RS09895	COG0513	Belongs to the DEAD box helicase family
HV99_RS09905	COG0189	ligase activity
HV99_RS09905	COG4067	protein conserved in archaea
HV99_RS09915	COG0477	Major facilitator Superfamily
HV99_RS09920	COG0542	response to heat
HV99_RS09930	COG0204	Acyl-transferase
HV99_RS09940	COG0745	RESPONSE REGULATOR receiver
HV99_RS09945	COG2205	protein histidine kinase activity
HV99_RS09950	COG4452	Inner membrane protein CreD
HV99_RS09980	COG4774	siderophore transport
HV99_RS09985	COG3712	iron ion homeostasis
HV99_RS09990	COG1595	DNA-templated transcription, initiation
HV99_RS09995	COG0625	glutathione transferase activity
HV99_RS10005	COG1309	transcriptional regulator
HV99_RS10010	COG1953	Uracil, thiamine, allantoin
HV99_RS10030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV99_RS10065	COG2005	Transcriptional regulator
HV99_RS10065	COG3585	molybdate ion transport
HV99_RS10070	COG5544	Lipoprotein
HV99_RS10075	COG1040	competence protein
HV99_RS10095	COG0511	ligase activity, forming carbon-carbon bonds
HV99_RS10110	COG1984	allophanate hydrolase subunit 2
HV99_RS10125	COG3121	Chaperone
HV99_RS10140	COG2226	methyltransferase
HV99_RS10140	COG1073	alpha beta
HV99_RS10160	COG1960	acyl-CoA dehydrogenase activity
HV99_RS10165	COG1960	acyl-CoA dehydrogenase activity
HV99_RS10170	COG1960	acyl-CoA dehydrogenase activity
HV99_RS10180	COG1648	precorrin-2 dehydrogenase activity
HV99_RS10180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV99_RS10270	COG0583	DNA-binding transcription factor activity
HV99_RS10275	COG2258	MOSC domain
HV99_RS10285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV99_RS10305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS10315	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HV99_RS10370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV99_RS10375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV99_RS10385	COG3622	Belongs to the hyi family
HV99_RS10390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV99_RS10430	COG2081	HI0933 family
HV99_RS10435	COG1451	nucleotide metabolic process
HV99_RS10445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV99_RS10450	COG3152	Membrane
HV99_RS10455	COG1917	Cupin 2, conserved barrel domain protein
HV99_RS10455	COG4977	sequence-specific DNA binding
HV99_RS10460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV99_RS10545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV99_RS10565	COG2719	SpoVR family
HV99_RS10575	COG2766	serine protein kinase
HV99_RS10625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV99_RS10640	COG2197	response regulator
HV99_RS10650	COG3842	ATPase activity
HV99_RS10660	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV99_RS10670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV99_RS10695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV99_RS10780	COG3179	chitinase
HV99_RS10815	COG1765	OsmC-like protein
HV99_RS10830	COG0537	adenosine 5'-monophosphoramidase activity
HV99_RS10840	COG0300	oxidoreductase activity
HV99_RS10855	COG1981	membrane
HV99_RS10885	COG0739	heme binding
HV99_RS11050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HV99_RS11175	COG2814	Major facilitator Superfamily
HV99_RS11200	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV99_RS11210	COG3433	isochorismatase activity
HV99_RS11210	COG2226	methyltransferase
HV99_RS11210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV99_RS11215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV99_RS11215	COG2226	methyltransferase
HV99_RS11215	COG3433	isochorismatase activity
HV99_RS11225	COG1132	(ABC) transporter
HV99_RS11225	COG2375	cellular response to nickel ion
HV99_RS11305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS11310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS11320	COG2706	6-phosphogluconolactonase activity
HV99_RS11340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV99_RS11345	COG1960	acyl-CoA dehydrogenase activity
HV99_RS11355	COG4191	Histidine kinase
HV99_RS11360	COG4566	intracellular signal transduction
HV99_RS11365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS11370	COG0765	amino acid transport
HV99_RS11375	COG0765	amino acid transport
HV99_RS11395	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS11400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV99_RS11405	COG2271	Major facilitator Superfamily
HV99_RS11450	COG2226	methyltransferase
HV99_RS11460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV99_RS11475	COG0251	oxidation-reduction process
HV99_RS11485	COG0693	protein deglycase activity
HV99_RS11490	COG0492	ferredoxin-NADP+ reductase activity
HV99_RS11495	COG1959	2 iron, 2 sulfur cluster binding
HV99_RS11525	COG0154	amidase activity
HV99_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS11535	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV99_RS11540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV99_RS11545	COG4592	Periplasmic binding protein
HV99_RS11550	COG1120	ATPase activity
HV99_RS11560	COG4774	siderophore transport
HV99_RS11560	COG1629	transport
HV99_RS11565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV99_RS11570	COG4991	sh3 domain protein
HV99_RS11575	COG1063	alcohol dehydrogenase
HV99_RS11585	COG0022	dehydrogenase e1 component
HV99_RS11590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HV99_RS11595	COG3199	ATP-NAD kinase
HV99_RS11605	COG3284	Transcriptional regulator
HV99_RS11630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS11660	COG2814	Major facilitator Superfamily
HV99_RS11665	COG1846	Transcriptional regulator
HV99_RS11675	COG3278	Belongs to the heme-copper respiratory oxidase family
HV99_RS11680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV99_RS11690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV99_RS11705	COG3971	2-oxopent-4-enoate hydratase activity
HV99_RS11710	COG2271	Major facilitator Superfamily
HV99_RS11720	COG3384	dioxygenase
HV99_RS11725	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS11765	COG1611	Belongs to the LOG family
HV99_RS11820	COG2259	Doxx family
HV99_RS11830	COG2205	protein histidine kinase activity
HV99_RS11855	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS11860	COG1063	alcohol dehydrogenase
HV99_RS11865	COG2271	Major facilitator Superfamily
HV99_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS11905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HV99_RS11920	COG3121	Chaperone
HV99_RS11925	COG3188	usher protein
HV99_RS11930	COG3121	Chaperone
HV99_RS11945	COG2197	response regulator
HV99_RS11985	COG0531	amino acid
HV99_RS12005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV99_RS12015	COG3047	cAMP biosynthetic process
HV99_RS12030	COG1136	(ABC) transporter
HV99_RS12045	COG3118	belongs to the thioredoxin family
HV99_RS12050	COG2264	protein methyltransferase activity
HV99_RS12065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV99_RS12065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV99_RS12090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV99_RS12095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV99_RS12105	COG3577	Aspartyl protease
HV99_RS12130	COG0142	geranyltranstransferase activity
HV99_RS12140	COG4948	Mandelate Racemase Muconate Lactonizing
HV99_RS12160	COG1131	(ABC) transporter
HV99_RS12165	COG5002	protein histidine kinase activity
HV99_RS12185	COG0745	RESPONSE REGULATOR receiver
HV99_RS12195	COG3228	Belongs to the MtfA family
HV99_RS12200	COG0586	Pfam SNARE associated Golgi protein
HV99_RS12215	COG0456	acetyltransferase
HV99_RS12225	COG4303	Ethanolamine ammonia lyase large subunit
HV99_RS12230	COG0531	amino acid
HV99_RS12240	COG3284	Transcriptional regulator
HV99_RS12245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV99_RS12260	COG0702	epimerase
HV99_RS12280	COG1346	cytolysis
HV99_RS12330	COG0768	penicillin binding
HV99_RS12335	COG0772	Belongs to the SEDS family
HV99_RS12340	COG2951	lytic endotransglycosylase activity
HV99_RS12350	COG1686	Belongs to the peptidase S11 family
HV99_RS12380	COG2951	lytic endotransglycosylase activity
HV99_RS12415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV99_RS12425	COG4535	Mg2 and Co2 transporter CorC
HV99_RS12435	COG1702	phosphate starvation-inducible protein PhoH
HV99_RS12465	COG0351	phosphomethylpyrimidine kinase
HV99_RS12470	COG2205	protein histidine kinase activity
HV99_RS12470	COG2198	Histidine kinase
HV99_RS12470	COG0784	Response regulator, receiver
HV99_RS12480	COG1960	acyl-CoA dehydrogenase activity
HV99_RS12490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV99_RS12530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV99_RS12540	COG1643	Atp-dependent helicase
HV99_RS12585	COG3416	Protein conserved in bacteria
HV99_RS12595	COG0513	Belongs to the DEAD box helicase family
HV99_RS12605	COG2197	response regulator
HV99_RS12610	COG2200	EAL domain
HV99_RS12610	COG2202	Pas domain
HV99_RS12610	COG2199	diguanylate cyclase activity
HV99_RS12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS12615	COG2205	protein histidine kinase activity
HV99_RS12635	COG1946	Acyl-CoA thioesterase
HV99_RS12655	COG4521	taurine ABC transporter
HV99_RS12665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS12670	COG2175	clavaminate synthase activity
HV99_RS12680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV99_RS12695	COG1271	oxidase subunit
HV99_RS12700	COG1294	oxidase, subunit
HV99_RS12710	COG2207	Transcriptional regulator
HV99_RS12720	COG0183	Belongs to the thiolase family
HV99_RS12725	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS12750	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HV99_RS12760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV99_RS12770	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV99_RS12775	COG0303	'Molybdopterin
HV99_RS12780	COG0826	peptidase U32
HV99_RS12785	COG0826	peptidase U32
HV99_RS12790	COG3154	lipid carrier protein
HV99_RS12840	COG4772	TonB-dependent receptor
HV99_RS12845	COG3712	iron ion homeostasis
HV99_RS12850	COG1595	DNA-templated transcription, initiation
HV99_RS12860	COG0697	spore germination
HV99_RS12870	COG0583	DNA-binding transcription factor activity
HV99_RS12890	COG1566	PFAM secretion protein HlyD family protein
HV99_RS12940	COG0300	oxidoreductase activity
HV99_RS12945	COG2226	methyltransferase
HV99_RS12960	COG2197	response regulator
HV99_RS12965	COG3850	Histidine kinase
HV99_RS12975	COG2223	nitrite transmembrane transporter activity
HV99_RS12980	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV99_RS12985	COG1140	nitrate reductase beta subunit
HV99_RS12990	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV99_RS12995	COG2181	nitrate reductase activity
HV99_RS13000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV99_RS13010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS13035	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS13045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS13110	COG0583	DNA-binding transcription factor activity
HV99_RS13140	COG0490	domain, Protein
HV99_RS13140	COG0471	metal ion transport
HV99_RS13145	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV99_RS13150	COG4120	Belongs to the binding-protein-dependent transport system permease family
HV99_RS13195	COG0795	lipopolysaccharide-transporting ATPase activity
HV99_RS13200	COG0795	lipopolysaccharide-transporting ATPase activity
HV99_RS13210	COG2200	EAL domain
HV99_RS13230	COG1862	Preprotein translocase
HV99_RS13245	COG3134	Outer membrane lipoprotein
HV99_RS13260	COG1045	serine acetyltransferase
HV99_RS13350	COG0436	Aminotransferase
HV99_RS13365	COG0667	Aldo Keto reductase
HV99_RS13405	COG0739	heme binding
HV99_RS13415	COG2847	Copper chaperone PCu(A)C
HV99_RS13425	COG1335	isochorismatase
HV99_RS13440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HV99_RS13450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV99_RS13455	COG0583	DNA-binding transcription factor activity
HV99_RS13515	COG0738	Major facilitator superfamily
HV99_RS13525	COG2130	NADP-dependent
HV99_RS13530	COG2132	Multicopper oxidase
HV99_RS13535	COG0590	tRNA wobble adenosine to inosine editing
HV99_RS13570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV99_RS13570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV99_RS13575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV99_RS13580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV99_RS13585	COG2188	Transcriptional regulator
HV99_RS13625	COG0477	Major facilitator Superfamily
HV99_RS13630	COG4536	flavin adenine dinucleotide binding
HV99_RS13640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV99_RS13665	COG1607	acyl-coa hydrolase
HV99_RS13685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV99_RS13710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HV99_RS13735	COG2255	four-way junction helicase activity
HV99_RS13750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV99_RS13760	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS13805	COG2197	response regulator
HV99_RS13810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV99_RS13830	COG0477	Major facilitator Superfamily
HV99_RS13865	COG5001	Diguanylate cyclase
HV99_RS13865	COG3706	GGDEF domain
HV99_RS13865	COG2203	Gaf domain
HV99_RS13865	COG4251	negative regulation of phosphorylation
HV99_RS13870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV99_RS13900	COG3064	Membrane
HV99_RS13900	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HV99_RS13900	COG1073	alpha beta
HV99_RS13915	COG2885	chlorophyll binding
HV99_RS13930	COG0789	Transcriptional regulator
HV99_RS13950	COG1214	PFAM Peptidase M22, glycoprotease
HV99_RS13960	COG1801	Protein of unknown function DUF72
HV99_RS13965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HV99_RS13990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS14035	COG2166	iron-sulfur cluster assembly
HV99_RS14055	COG1393	Belongs to the ArsC family
HV99_RS14075	COG0025	NhaP-type Na H and K H
HV99_RS14080	COG0436	Aminotransferase
HV99_RS14090	COG0024	Methionine aminopeptidase
HV99_RS14170	COG1115	amino acid carrier protein
HV99_RS14220	COG2391	methyltransferase activity
HV99_RS14225	COG0583	DNA-binding transcription factor activity
HV99_RS14230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HV99_RS14235	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HV99_RS14285	COG1546	Belongs to the CinA family
HV99_RS14305	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HV99_RS14310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HV99_RS14315	COG3530	Putative quorum-sensing-regulated virulence factor
HV99_RS14330	COG1177	transmembrane transport
HV99_RS14335	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV99_RS14345	COG3148	PFAM DTW domain containing protein
HV99_RS14365	COG0069	glutamate synthase activity
HV99_RS14390	COG0531	amino acid
HV99_RS14395	COG2169	Transcriptional regulator
HV99_RS14395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV99_RS14400	COG0477	Major facilitator Superfamily
HV99_RS14405	COG0583	DNA-binding transcription factor activity
HV99_RS14410	COG1960	acyl-CoA dehydrogenase activity
HV99_RS14415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HV99_RS14420	COG1024	Enoyl-CoA hydratase
HV99_RS14425	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV99_RS14430	COG0183	Belongs to the thiolase family
HV99_RS14440	COG0583	DNA-binding transcription factor activity
HV99_RS14475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV99_RS14515	COG2814	Major facilitator Superfamily
HV99_RS14555	COG0583	DNA-binding transcription factor activity
HV99_RS14565	COG0084	hydrolase, TatD family'
HV99_RS14570	COG1609	Transcriptional regulator
HV99_RS14580	COG1105	Belongs to the carbohydrate kinase PfkB family
HV99_RS14585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV99_RS14585	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV99_RS14585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV99_RS14695	COG3842	ATPase activity
HV99_RS14715	COG0243	molybdopterin cofactor binding
HV99_RS14720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV99_RS14725	COG2223	nitrite transmembrane transporter activity
HV99_RS14740	COG0450	alkyl hydroperoxide reductase
HV99_RS14770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS14805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV99_RS14810	COG2264	protein methyltransferase activity
HV99_RS14820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV99_RS14875	COG0489	protein tyrosine kinase activity
HV99_RS14920	COG0791	NLP P60 protein
HV99_RS14935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HV99_RS14940	COG0668	transmembrane transport
HV99_RS14945	COG0477	Major facilitator Superfamily
HV99_RS14950	COG0513	Belongs to the DEAD box helicase family
HV99_RS14970	COG0784	Response regulator, receiver
HV99_RS14970	COG2205	protein histidine kinase activity
HV99_RS14970	COG5002	protein histidine kinase activity
HV99_RS14975	COG1363	Peptidase, m42
HV99_RS14980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV99_RS14980	COG0189	ligase activity
HV99_RS14985	COG0367	asparagine synthase
HV99_RS15010	COG0183	Belongs to the thiolase family
HV99_RS15030	COG0450	alkyl hydroperoxide reductase
HV99_RS15035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS15040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS15050	COG0431	NADPH-dependent FMN reductase
HV99_RS15055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS15065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS15090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV99_RS15115	COG0583	DNA-binding transcription factor activity
HV99_RS15120	COG1380	Effector of murein hydrolase LrgA
HV99_RS15125	COG1346	cytolysis
HV99_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS15150	COG1024	Enoyl-CoA hydratase
HV99_RS15160	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV99_RS15205	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV99_RS15245	COG1629	transport
HV99_RS15300	COG0583	DNA-binding transcription factor activity
HV99_RS15375	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV99_RS15380	COG3639	organic phosphonate transmembrane transporter activity
HV99_RS15385	COG2188	Transcriptional regulator
HV99_RS15390	COG3624	Phosphonate C-P lyase system protein PhnG
HV99_RS15400	COG3626	phosphonate metabolism
HV99_RS15405	COG3627	carbon phosphorus lyase activity
HV99_RS15410	COG4107	phosphonate C-P lyase system protein PhnK
HV99_RS15415	COG4778	phosphonate C-P lyase system protein PhnL
HV99_RS15420	COG3454	Phosphonate metabolism
HV99_RS15430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV99_RS15520	COG0697	spore germination
HV99_RS15545	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HV99_RS15565	COG0835	chemotaxis
HV99_RS15565	COG0784	Response regulator, receiver
HV99_RS15580	COG0745	RESPONSE REGULATOR receiver
HV99_RS15590	COG0514	ATP-dependent DNA helicase (RecQ)
HV99_RS15595	COG4251	negative regulation of phosphorylation
HV99_RS15595	COG3706	GGDEF domain
HV99_RS15595	COG2203	Gaf domain
HV99_RS15595	COG5001	Diguanylate cyclase
HV99_RS15615	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV99_RS15655	COG2124	cytochrome p450
HV99_RS15660	COG4221	oxidoreductase activity
HV99_RS15705	COG0583	DNA-binding transcription factor activity
HV99_RS15735	COG3639	organic phosphonate transmembrane transporter activity
HV99_RS15745	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV99_RS15750	COG2084	Dehydrogenase
HV99_RS15765	COG0589	response to stress
HV99_RS15805	COG2814	Major facilitator Superfamily
HV99_RS15810	COG2030	dehydratase
HV99_RS15815	COG2267	carboxylic ester hydrolase activity
HV99_RS15820	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS15825	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS15835	COG1643	Atp-dependent helicase
HV99_RS15845	COG0537	adenosine 5'-monophosphoramidase activity
HV99_RS15895	COG1595	DNA-templated transcription, initiation
HV99_RS15965	COG1201	RNA secondary structure unwinding
HV99_RS15970	COG2205	protein histidine kinase activity
HV99_RS15970	COG0784	Response regulator, receiver
HV99_RS15985	COG4772	TonB-dependent receptor
HV99_RS16000	COG2076	Multidrug Resistance protein
HV99_RS16005	COG0385	Bile acid
HV99_RS16070	COG0604	alcohol dehydrogenase
HV99_RS16070	COG3321	synthase
HV99_RS16075	COG0560	Phosphoserine phosphatase
HV99_RS16090	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV99_RS16120	COG0564	pseudouridine synthase activity
HV99_RS16130	COG2894	cell division
HV99_RS16140	COG1560	Kdo2-lipid A biosynthetic process
HV99_RS16155	COG2853	Lipoprotein
HV99_RS16175	COG3162	membrane
HV99_RS16180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV99_RS16210	COG1132	(ABC) transporter
HV99_RS16220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV99_RS16245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV99_RS16260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HV99_RS16260	COG0438	transferase activity, transferring glycosyl groups
HV99_RS16290	COG1127	ABC transporter
HV99_RS16295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV99_RS16300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV99_RS16305	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV99_RS16310	COG0778	Nitroreductase
HV99_RS16330	COG0745	RESPONSE REGULATOR receiver
HV99_RS16340	COG2350	Protein conserved in bacteria
HV99_RS16350	COG0613	PHP domain protein
HV99_RS16355	COG0009	L-threonylcarbamoyladenylate synthase
HV99_RS16365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HV99_RS16410	COG1175	transmembrane transport
HV99_RS16415	COG0395	ABC-type sugar transport system, permease component
HV99_RS16420	COG3842	ATPase activity
HV99_RS16430	COG0676	glucose-6-phosphate 1-epimerase activity
HV99_RS16475	COG0786	glutamate:sodium symporter activity
HV99_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS16505	COG0402	S-adenosylhomocysteine deaminase activity
HV99_RS16535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HV99_RS16585	COG0367	asparagine synthase
HV99_RS16590	COG0438	transferase activity, transferring glycosyl groups
HV99_RS16595	COG0438	transferase activity, transferring glycosyl groups
HV99_RS16605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV99_RS16645	COG0583	DNA-binding transcription factor activity
HV99_RS16680	COG0596	Alpha beta hydrolase
HV99_RS16685	COG0800	Aldolase
HV99_RS16700	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS16720	COG0583	DNA-binding transcription factor activity
HV99_RS16725	COG0251	oxidation-reduction process
HV99_RS16745	COG2226	methyltransferase
HV99_RS16785	COG0285	dihydrofolate synthase activity
HV99_RS16790	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV99_RS16795	COG1286	toxin biosynthetic process
HV99_RS16895	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV99_RS16895	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS16920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV99_RS16930	COG3139	Protein of unknown function (DUF1315)
HV99_RS16940	COG0308	aminopeptidase N
HV99_RS16970	COG0745	RESPONSE REGULATOR receiver
HV99_RS17005	COG0714	Associated with various cellular activities
HV99_RS17025	COG1335	isochorismatase
HV99_RS17035	COG2342	PFAM TM1410 hypothetical-related protein
HV99_RS17060	COG0297	glycogen (starch) synthase activity
HV99_RS17110	COG3130	regulation of translation
HV99_RS17120	COG2027	D-alanyl-D-alanine carboxypeptidase
HV99_RS17125	COG3171	Protein conserved in bacteria
HV99_RS17130	COG2197	response regulator
HV99_RS17135	COG2205	protein histidine kinase activity
HV99_RS17135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS17160	COG0004	ammonium transporteR
HV99_RS17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV99_RS17180	COG0625	glutathione transferase activity
HV99_RS17185	COG1309	transcriptional regulator
HV99_RS17215	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV99_RS17240	COG1070	Carbohydrate kinase
HV99_RS17260	COG0741	lytic transglycosylase activity
HV99_RS17265	COG0488	(ABC) transporter
HV99_RS17275	COG0589	response to stress
HV99_RS17350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV99_RS17395	COG1477	protein flavinylation
HV99_RS17410	COG0584	glycerophosphoryl diester phosphodiesterase
HV99_RS17425	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV99_RS17445	COG0658	competence protein
HV99_RS17445	COG2333	competence protein COMEC
HV99_RS17450	COG0811	peptide transport
HV99_RS17455	COG0848	biopolymer transport protein
HV99_RS17475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV99_RS17495	COG0546	phosphoglycolate phosphatase activity
HV99_RS17500	COG0616	signal peptide processing
HV99_RS17500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV99_RS17510	COG1399	metal-binding, possibly nucleic acid-binding protein
HV99_RS17540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV99_RS17550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV99_RS17570	COG0084	hydrolase, TatD family'
HV99_RS17655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV99_RS17670	COG0183	Belongs to the thiolase family
HV99_RS17680	COG2233	PERMEase
HV99_RS17690	COG3038	cytochrome b561
HV99_RS17710	COG2814	Major facilitator Superfamily
HV99_RS17715	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS17720	COG1309	transcriptional regulator
HV99_RS17755	COG4160	amino acid transport
HV99_RS17760	COG4215	(ABC) transporter
HV99_RS17765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS17770	COG1473	amidohydrolase
HV99_RS17775	COG0583	DNA-binding transcription factor activity
HV99_RS17780	COG0840	transmembrane signaling receptor activity
HV99_RS17810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV99_RS17820	COG1120	ATPase activity
HV99_RS17850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV99_RS17880	COG3047	cAMP biosynthetic process
HV99_RS17880	COG2885	chlorophyll binding
HV99_RS17885	COG2197	response regulator
HV99_RS17895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV99_RS17900	COG1595	DNA-templated transcription, initiation
HV99_RS17915	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS17930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HV99_RS17935	COG1960	acyl-CoA dehydrogenase activity
HV99_RS17940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HV99_RS17955	COG1309	transcriptional regulator
HV99_RS17985	COG0583	DNA-binding transcription factor activity
HV99_RS17995	COG0583	DNA-binding transcription factor activity
HV99_RS18005	COG0714	Associated with various cellular activities
HV99_RS18055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV99_RS18060	COG2259	Doxx family
HV99_RS18075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV99_RS18090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV99_RS18095	COG4181	ATPase activity
HV99_RS18135	COG1764	response to oxidative stress
HV99_RS18140	COG1846	Transcriptional regulator
HV99_RS18145	COG0583	DNA-binding transcription factor activity
HV99_RS18155	COG0583	DNA-binding transcription factor activity
HV99_RS18165	COG3214	Protein conserved in bacteria
HV99_RS18170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HV99_RS18180	COG1024	Enoyl-CoA hydratase
HV99_RS18230	COG2866	Carboxypeptidase
HV99_RS18245	COG0436	Aminotransferase
HV99_RS18255	COG0386	Belongs to the glutathione peroxidase family
HV99_RS18260	COG1846	Transcriptional regulator
HV99_RS18265	COG2205	protein histidine kinase activity
HV99_RS18265	COG5002	protein histidine kinase activity
HV99_RS18265	COG0784	Response regulator, receiver
HV99_RS18270	COG2255	four-way junction helicase activity
HV99_RS18275	COG1956	GAF domain-containing protein
HV99_RS18280	COG0625	glutathione transferase activity
HV99_RS18375	COG0625	glutathione transferase activity
HV99_RS18380	COG1131	(ABC) transporter
HV99_RS18385	COG0842	Transport permease protein
HV99_RS18430	COG2188	Transcriptional regulator
HV99_RS18440	COG2853	Lipoprotein
HV99_RS18450	COG0745	RESPONSE REGULATOR receiver
HV99_RS18490	COG5434	Belongs to the glycosyl hydrolase 28 family
HV99_RS18520	COG3655	Transcriptional regulator
HV99_RS18560	COG2116	formate transmembrane transporter activity
HV99_RS18565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS18630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV99_RS18630	COG1024	Enoyl-CoA hydratase
HV99_RS18640	COG2837	iron assimilation
HV99_RS18725	COG1238	metal cluster binding
HV99_RS18735	COG1295	ribonuclease BN
HV99_RS18765	COG0024	Methionine aminopeptidase
HV99_RS18850	COG2963	transposase activity
HV99_RS18880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HV99_RS18880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HV99_RS18890	COG0542	response to heat
HV99_RS18925	COG0789	Transcriptional regulator
HV99_RS18935	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV99_RS18935	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS18940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HV99_RS18945	COG0243	molybdopterin cofactor binding
HV99_RS18965	COG1280	lysine exporter protein (LysE YggA)
HV99_RS18980	COG0542	response to heat
HV99_RS19050	COG1607	acyl-coa hydrolase
HV99_RS19055	COG1959	2 iron, 2 sulfur cluster binding
HV99_RS19070	COG2819	hydrolase of the alpha beta superfamily
HV99_RS19125	COG4106	trans-aconitate 2-methyltransferase activity
HV99_RS19135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV99_RS19140	COG1459	type II secretion system
HV99_RS19150	COG2165	general secretion pathway protein
HV99_RS19190	COG0720	synthase
HV99_RS19195	COG3604	Transcriptional regulator
HV99_RS19255	COG0840	transmembrane signaling receptor activity
HV99_RS19260	COG2056	Na+-H+ antiporter family
HV99_RS19275	COG2226	methyltransferase
HV99_RS19370	COG2153	protein acetylation
HV99_RS19375	COG2850	peptidyl-arginine hydroxylation
HV99_RS19415	COG1278	Cold shock
HV99_RS19425	COG0542	response to heat
HV99_RS19430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV99_RS19445	COG0492	ferredoxin-NADP+ reductase activity
HV99_RS19460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV99_RS19475	COG0435	Glutathione S-transferase
HV99_RS19480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV99_RS19485	COG2920	part of a sulfur-relay system
HV99_RS19550	COG0419	ATPase involved in DNA repair
HV99_RS19555	COG1674	ftsk spoiiie
HV99_RS19595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV99_RS19650	COG1598	PFAM Uncharacterised protein family UPF0150
HV99_RS19655	COG1724	mRNA binding
HV99_RS19745	COG1196	nuclear chromosome segregation
HV99_RS19745	COG1196	nuclear chromosome segregation
HV99_RS19775	COG3179	chitinase
HV99_RS19795	COG2135	peptidase activity
HV99_RS20005	COG4695	Portal protein
HV99_RS20025	COG0583	DNA-binding transcription factor activity
HV99_RS20030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV99_RS20035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS20045	COG1960	acyl-CoA dehydrogenase activity
HV99_RS20050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS20060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS20075	COG2197	response regulator
HV99_RS20080	COG4771	TonB-dependent receptor
HV99_RS20120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV99_RS20120	COG0784	Response regulator, receiver
HV99_RS20120	COG2205	protein histidine kinase activity
HV99_RS20120	COG2198	Histidine kinase
HV99_RS20140	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV99_RS20155	COG1522	sequence-specific DNA binding
HV99_RS20185	COG4191	Histidine kinase
HV99_RS20210	COG2203	Gaf domain
HV99_RS20210	COG3706	GGDEF domain
HV99_RS20210	COG4251	negative regulation of phosphorylation
HV99_RS20210	COG5001	Diguanylate cyclase
HV99_RS20220	COG0659	secondary active sulfate transmembrane transporter activity
HV99_RS20255	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS20265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HV99_RS20275	COG0183	Belongs to the thiolase family
HV99_RS20280	COG1960	acyl-CoA dehydrogenase activity
HV99_RS20330	COG0729	surface antigen
HV99_RS20340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV99_RS20345	COG2267	carboxylic ester hydrolase activity
HV99_RS20350	COG0671	phosphoesterase, PA-phosphatase related
HV99_RS20350	COG2453	phosphatase
HV99_RS20365	COG4589	Belongs to the CDS family
HV99_RS20370	COG0667	Aldo Keto reductase
HV99_RS20380	COG1115	amino acid carrier protein
HV99_RS20390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV99_RS20410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS20415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS20420	COG1538	Outer membrane efflux protein
HV99_RS20480	COG0543	2 iron, 2 sulfur cluster binding
HV99_RS20480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV99_RS20485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HV99_RS20490	COG4638	Rieske (2fe-2S)
HV99_RS20505	COG4948	Mandelate Racemase Muconate Lactonizing
HV99_RS20515	COG3485	protocatechuate 3,4-dioxygenase
HV99_RS20550	COG2807	transmembrane transport
HV99_RS20555	COG0590	tRNA wobble adenosine to inosine editing
HV99_RS20570	COG2318	DinB family
HV99_RS20630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV99_RS20635	COG2863	cytochrome
HV99_RS20640	COG3258	Cytochrome c
HV99_RS20645	COG0642	Histidine kinase
HV99_RS20680	COG0625	glutathione transferase activity
HV99_RS20700	COG0583	DNA-binding transcription factor activity
HV99_RS20705	COG1595	DNA-templated transcription, initiation
HV99_RS20710	COG3712	iron ion homeostasis
HV99_RS20775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV99_RS20785	COG2382	esterase
HV99_RS20805	COG0583	DNA-binding transcription factor activity
HV99_RS20825	COG1760	l-serine dehydratase
HV99_RS20830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HV99_RS20865	COG2217	Heavy metal translocating P-type atpase
HV99_RS20880	COG0583	DNA-binding transcription factor activity
HV99_RS20895	COG1566	PFAM secretion protein HlyD family protein
HV99_RS20970	COG1335	isochorismatase
HV99_RS20980	COG0583	DNA-binding transcription factor activity
HV99_RS21015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV99_RS21020	COG1121	(ABC) transporter
HV99_RS21115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS21140	COG0735	belongs to the Fur family
HV99_RS21150	COG1304	FMN binding
HV99_RS21180	COG4566	intracellular signal transduction
HV99_RS21270	COG3829	transcription factor binding
HV99_RS21295	COG3829	transcription factor binding
HV99_RS21300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV99_RS21305	COG0584	glycerophosphoryl diester phosphodiesterase
HV99_RS21310	COG2011	ABC-type metal ion transport system permease component
HV99_RS21320	COG1464	Belongs to the NlpA lipoprotein family
HV99_RS21345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV99_RS21350	COG1070	Carbohydrate kinase
HV99_RS21355	COG0246	Mannitol dehydrogenase
HV99_RS21390	COG4771	TonB-dependent receptor
HV99_RS21405	COG1917	Cupin 2, conserved barrel domain protein
HV99_RS21405	COG4977	sequence-specific DNA binding
HV99_RS21420	COG1116	anion transmembrane transporter activity
HV99_RS21425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV99_RS21430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS21450	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS21460	COG3265	gluconokinase activity
HV99_RS21465	COG1609	Transcriptional regulator
HV99_RS21475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS21480	COG0583	DNA-binding transcription factor activity
HV99_RS21500	COG1396	sequence-specific DNA binding
HV99_RS21510	COG2175	clavaminate synthase activity
HV99_RS21520	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV99_RS21525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS21550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV99_RS21550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV99_RS21560	COG3469	chitinase activity
HV99_RS21565	COG2188	Transcriptional regulator
HV99_RS21570	COG1053	succinate dehydrogenase
HV99_RS21585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV99_RS21615	COG4772	TonB-dependent receptor
HV99_RS21660	COG0431	NADPH-dependent FMN reductase
HV99_RS21665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV99_RS21675	COG0640	Transcriptional regulator
HV99_RS21680	COG2207	Transcriptional regulator
HV99_RS21685	COG1064	alcohol dehydrogenase
HV99_RS21710	COG1309	transcriptional regulator
HV99_RS21720	COG2329	Antibiotic biosynthesis monooxygenase
HV99_RS21755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV99_RS21765	COG1609	Transcriptional regulator
HV99_RS21795	COG0252	asparaginase activity
HV99_RS21800	COG1115	amino acid carrier protein
HV99_RS21845	COG1053	succinate dehydrogenase
HV99_RS21855	COG0728	peptidoglycan biosynthetic process
HV99_RS21915	COG2258	MOSC domain
HV99_RS21950	COG5290	Psort location Cytoplasmic, score
HV99_RS21980	COG2963	transposase activity
HV99_RS21990	COG2508	Transcriptional regulator
HV99_RS22000	COG4447	cellulose binding
HV99_RS22005	COG2409	Drug exporters of the RND superfamily
HV99_RS22025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS22040	COG2072	flavoprotein involved in K transport
HV99_RS22055	COG0531	amino acid
HV99_RS22060	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS22065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV99_RS22080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV99_RS22085	COG3162	membrane
HV99_RS22090	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS22095	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS22125	COG3008	intermembrane lipid transfer
HV99_RS22130	COG2995	paraquat-inducible protein a
HV99_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS22145	COG4948	Mandelate Racemase Muconate Lactonizing
HV99_RS22150	COG2271	Major facilitator Superfamily
HV99_RS22165	COG3618	amidohydrolase
HV99_RS22170	COG2271	Major facilitator Superfamily
HV99_RS22205	COG0765	amino acid transport
HV99_RS22210	COG0765	amino acid transport
HV99_RS22225	COG2084	Dehydrogenase
HV99_RS22235	COG2130	NADP-dependent
HV99_RS22240	COG1309	transcriptional regulator
HV99_RS22260	COG0366	Alpha amylase catalytic
HV99_RS22265	COG0517	IMP dehydrogenase activity
HV99_RS22285	COG1063	alcohol dehydrogenase
HV99_RS22300	COG3546	catalase activity
HV99_RS22305	COG3685	Protein conserved in bacteria
HV99_RS22330	COG2890	protein-(glutamine-N5) methyltransferase activity
HV99_RS22345	COG0784	Response regulator, receiver
HV99_RS22345	COG4191	Histidine kinase
HV99_RS22375	COG1363	Peptidase, m42
HV99_RS22415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV99_RS22455	COG3568	Endonuclease Exonuclease Phosphatase
HV99_RS22460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV99_RS22465	COG0392	lysyltransferase activity
HV99_RS22475	COG0366	Alpha amylase catalytic
HV99_RS22495	COG1285	pathogenesis
HV99_RS22515	COG0058	SHG alpha-glucan phosphorylase activity
HV99_RS22530	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS22535	COG1546	Belongs to the CinA family
HV99_RS22565	COG2323	membrane
HV99_RS22585	COG3121	Chaperone
HV99_RS22595	COG3188	usher protein
HV99_RS22600	COG3121	Chaperone
HV99_RS22610	COG3969	phosphoadenosine phosphosulfate
HV99_RS22620	COG1475	DNA binding
HV99_RS22625	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS22630	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HV99_RS22635	COG0583	DNA-binding transcription factor activity
HV99_RS22655	COG1063	alcohol dehydrogenase
HV99_RS22665	COG2169	Transcriptional regulator
HV99_RS22665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV99_RS22680	COG0583	DNA-binding transcription factor activity
HV99_RS22685	COG2814	Major facilitator Superfamily
HV99_RS22705	COG1984	allophanate hydrolase subunit 2
HV99_RS22715	COG0300	oxidoreductase activity
HV99_RS22750	COG2814	Major facilitator Superfamily
HV99_RS22760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV99_RS22780	COG0596	Alpha beta hydrolase
HV99_RS22785	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HV99_RS22790	COG0367	asparagine synthase
HV99_RS22800	COG1522	sequence-specific DNA binding
HV99_RS22815	COG1113	amino acid transport
HV99_RS22820	COG2010	Cytochrome c
HV99_RS22825	COG2010	Cytochrome c
HV99_RS22845	COG3153	acetyltransferase
HV99_RS22845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV99_RS22850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV99_RS22855	COG5001	Diguanylate cyclase
HV99_RS22870	COG2192	nodulation
HV99_RS22875	COG2814	Major facilitator Superfamily
HV99_RS22905	COG1104	cysteine desulfurase activity
HV99_RS22910	COG4172	Belongs to the ABC transporter superfamily
HV99_RS22915	COG4239	(ABC) transporter, permease
HV99_RS22920	COG4174	ABC transporter (Permease)
HV99_RS22930	COG4771	TonB-dependent receptor
HV99_RS22945	COG0583	DNA-binding transcription factor activity
HV99_RS22965	COG1595	DNA-templated transcription, initiation
HV99_RS22980	COG2207	Transcriptional regulator
HV99_RS23000	COG0564	pseudouridine synthase activity
HV99_RS23010	COG0531	amino acid
HV99_RS23015	COG0174	glutamine synthetase
HV99_RS23055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV99_RS23075	COG1522	sequence-specific DNA binding
HV99_RS23115	COG1309	transcriptional regulator
HV99_RS23120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS23125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS23135	COG3204	pilus organization
HV99_RS23140	COG0789	Transcriptional regulator
HV99_RS23145	COG1960	acyl-CoA dehydrogenase activity
HV99_RS23150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HV99_RS23180	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV99_RS23190	COG2271	Major facilitator Superfamily
HV99_RS23195	COG3290	protein histidine kinase activity
HV99_RS23195	COG3829	transcription factor binding
HV99_RS23200	COG2610	gluconate transmembrane transporter activity
HV99_RS23205	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS23210	COG2031	fatty acid transporter
HV99_RS23225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV99_RS23230	COG0583	DNA-binding transcription factor activity
HV99_RS23235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HV99_RS23240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV99_RS23260	COG2205	protein histidine kinase activity
HV99_RS23325	COG3851	Histidine kinase
HV99_RS23340	COG2205	protein histidine kinase activity
HV99_RS23340	COG0784	Response regulator, receiver
HV99_RS23360	COG2194	sulfuric ester hydrolase activity
HV99_RS23405	COG0488	(ABC) transporter
HV99_RS23420	COG0583	DNA-binding transcription factor activity
HV99_RS23425	COG1278	Cold shock
HV99_RS23475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV99_RS23480	COG1609	Transcriptional regulator
HV99_RS23485	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV99_RS23490	COG1129	ABC transporter
HV99_RS23515	COG2010	Cytochrome c
HV99_RS23520	COG0753	catalase activity
HV99_RS23535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HV99_RS23540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HV99_RS23545	COG2080	2 iron, 2 sulfur cluster binding
HV99_RS23570	COG1944	ATP diphosphatase activity
HV99_RS23590	COG4771	TonB-dependent receptor
HV99_RS23595	COG0275	rRNA processing
HV99_RS23600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV99_RS23600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV99_RS23615	COG0579	oxidoreductase
HV99_RS23645	COG1595	DNA-templated transcription, initiation
HV99_RS23650	COG3712	iron ion homeostasis
HV99_RS23670	COG2814	Major facilitator Superfamily
HV99_RS23720	COG2197	response regulator
HV99_RS23745	COG2366	antibiotic biosynthetic process
HV99_RS23760	COG0625	glutathione transferase activity
HV99_RS23775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV99_RS23780	COG0417	DNA replication proofreading
HV99_RS23825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS23895	COG1309	transcriptional regulator
HV99_RS23915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HV99_RS23920	COG0583	DNA-binding transcription factor activity
HV99_RS23930	COG2354	Protein conserved in bacteria
HV99_RS23935	COG3278	Belongs to the heme-copper respiratory oxidase family
HV99_RS23945	COG2239	Acts as a magnesium transporter
HV99_RS23960	COG3706	GGDEF domain
HV99_RS23960	COG5001	Diguanylate cyclase
HV99_RS23960	COG2203	Gaf domain
HV99_RS23960	COG4251	negative regulation of phosphorylation
HV99_RS23965	COG4977	sequence-specific DNA binding
HV99_RS23970	COG3813	Protein conserved in bacteria
HV99_RS24035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV99_RS24060	COG0604	alcohol dehydrogenase
HV99_RS24065	COG0616	signal peptide processing
HV99_RS24085	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS24090	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS24095	COG0583	DNA-binding transcription factor activity
HV99_RS24120	COG1024	Enoyl-CoA hydratase
HV99_RS24130	COG0531	amino acid
HV99_RS24145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV99_RS24165	COG0741	lytic transglycosylase activity
HV99_RS24165	COG1388	LysM domain
HV99_RS24170	COG4166	transmembrane transport
HV99_RS24175	COG4166	transmembrane transport
HV99_RS24180	COG4174	ABC transporter (Permease)
HV99_RS24185	COG4239	(ABC) transporter, permease
HV99_RS24190	COG4172	Belongs to the ABC transporter superfamily
HV99_RS24200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV99_RS24215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV99_RS24235	COG0745	RESPONSE REGULATOR receiver
HV99_RS24240	COG2205	protein histidine kinase activity
HV99_RS24245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV99_RS24290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV99_RS24310	COG0589	response to stress
HV99_RS24330	COG3707	response regulator
HV99_RS24340	COG2223	nitrite transmembrane transporter activity
HV99_RS24345	COG0515	serine threonine protein kinase
HV99_RS24350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV99_RS24355	COG2146	nitrite reductase [NAD(P)H] activity
HV99_RS24360	COG0243	molybdopterin cofactor binding
HV99_RS24380	COG0668	transmembrane transport
HV99_RS24420	COG0189	ligase activity
HV99_RS24420	COG4067	protein conserved in archaea
HV99_RS24460	COG2909	trisaccharide binding
HV99_RS24465	COG2909	trisaccharide binding
HV99_RS24500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV99_RS24555	COG0519	Catalyzes the synthesis of GMP from XMP
HV99_RS24570	COG0667	Aldo Keto reductase
HV99_RS24585	COG0183	Belongs to the thiolase family
HV99_RS24605	COG1305	Transglutaminase-like
HV99_RS24615	COG2308	Evidence 4 Homologs of previously reported genes of
HV99_RS24620	COG0505	Belongs to the CarA family
HV99_RS24640	COG1317	bacterial-type flagellum organization
HV99_RS24750	COG4789	Type iii secretion
HV99_RS24800	COG4790	Type iii secretion
HV99_RS24805	COG4794	Type iii secretion
HV99_RS24810	COG4791	protein targeting
HV99_RS24815	COG4792	protein secretion
HV99_RS24895	COG2840	Smr protein MutS2
HV99_RS24915	COG0515	serine threonine protein kinase
HV99_RS24915	COG2815	serine threonine protein kinase
HV99_RS25000	COG0625	glutathione transferase activity
HV99_RS25005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV99_RS25020	COG3135	benzoate transporter
HV99_RS25035	COG2130	NADP-dependent
HV99_RS25045	COG0840	transmembrane signaling receptor activity
HV99_RS25055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV99_RS25095	COG0745	RESPONSE REGULATOR receiver
HV99_RS25100	COG2205	protein histidine kinase activity
HV99_RS25125	COG1960	acyl-CoA dehydrogenase activity
HV99_RS25135	COG1024	Enoyl-CoA hydratase
HV99_RS25140	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV99_RS25145	COG2186	Transcriptional regulator
HV99_RS25150	COG2807	transmembrane transport
HV99_RS25155	COG0628	permease
HV99_RS25165	COG0625	glutathione transferase activity
HV99_RS25195	COG1022	Amp-dependent synthetase and ligase
HV99_RS25225	COG5002	protein histidine kinase activity
HV99_RS25225	COG2205	protein histidine kinase activity
HV99_RS25225	COG0784	Response regulator, receiver
HV99_RS25265	COG1846	Transcriptional regulator
HV99_RS25270	COG2080	2 iron, 2 sulfur cluster binding
HV99_RS25275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HV99_RS25275	COG2010	Cytochrome c
HV99_RS25280	COG2010	Cytochrome c
HV99_RS25280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HV99_RS25285	COG2207	Transcriptional regulator
HV99_RS25360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV99_RS25365	COG1053	succinate dehydrogenase
HV99_RS25370	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV99_RS25375	COG2009	succinate dehydrogenase
HV99_RS25405	COG2084	Dehydrogenase
HV99_RS25420	COG3738	Protein conserved in bacteria
HV99_RS25445	COG0251	oxidation-reduction process
HV99_RS25450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS25455	COG0174	glutamine synthetase
HV99_RS25460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS25480	COG0840	transmembrane signaling receptor activity
HV99_RS25495	COG3278	Belongs to the heme-copper respiratory oxidase family
HV99_RS25510	COG2010	Cytochrome c
HV99_RS25515	COG3278	Belongs to the heme-copper respiratory oxidase family
HV99_RS25530	COG2010	Cytochrome c
HV99_RS25535	COG0348	domain, Protein
HV99_RS25545	COG2217	Heavy metal translocating P-type atpase
HV99_RS25585	COG2076	Multidrug Resistance protein
HV99_RS25615	COG1960	acyl-CoA dehydrogenase activity
HV99_RS25630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HV99_RS25665	COG1196	nuclear chromosome segregation
HV99_RS25695	COG0402	S-adenosylhomocysteine deaminase activity
HV99_RS25705	COG2252	PERMEase
HV99_RS25765	COG2233	PERMEase
HV99_RS25780	COG1309	transcriptional regulator
HV99_RS25790	COG3960	tartronate-semialdehyde synthase activity
HV99_RS25795	COG3622	Belongs to the hyi family
HV99_RS25800	COG2084	Dehydrogenase
HV99_RS25810	COG0469	pyruvate kinase activity
HV99_RS25815	COG4413	Urea transporter
HV99_RS25820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV99_RS25835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV99_RS25845	COG3192	ethanolamine utilization protein
HV99_RS25860	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV99_RS25865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV99_RS25940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HV99_RS25950	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS25955	COG1496	oxidoreductase activity
HV99_RS25980	COG0835	chemotaxis
HV99_RS25990	COG1192	Involved in chromosome partitioning
HV99_RS25995	COG1360	Flagellar Motor Protein
HV99_RS26000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV99_RS26010	COG0643	Histidine kinase
HV99_RS26010	COG0784	Response regulator, receiver
HV99_RS26010	COG2198	Histidine kinase
HV99_RS26040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HV99_RS26045	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HV99_RS26065	COG1987	bacterial-type flagellum assembly
HV99_RS26105	COG2832	Protein of unknown function (DUF454)
HV99_RS26120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV99_RS26125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS26135	COG3300	MHYT domain
HV99_RS26135	COG5001	Diguanylate cyclase
HV99_RS26170	COG0488	(ABC) transporter
HV99_RS26225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV99_RS26230	COG0583	DNA-binding transcription factor activity
HV99_RS26245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV99_RS26255	COG1196	nuclear chromosome segregation
HV99_RS26255	COG3264	Mechanosensitive ion channel
HV99_RS26260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV99_RS26260	COG0116	Belongs to the methyltransferase superfamily
HV99_RS26270	COG0210	DNA helicase
HV99_RS26295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HV99_RS26330	COG2207	Transcriptional regulator
HV99_RS26335	COG4221	oxidoreductase activity
HV99_RS26345	COG1247	-acetyltransferase
HV99_RS26365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV99_RS26375	COG0384	phenazine biosynthesis protein PhzF
HV99_RS26410	COG5006	permease, DMT superfamily
HV99_RS26425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV99_RS26440	COG3795	YCII-related domain
HV99_RS26450	COG2814	Major facilitator Superfamily
HV99_RS26455	COG4941	Belongs to the sigma-70 factor family
HV99_RS26465	COG3795	YCII-related domain
HV99_RS26475	COG2197	response regulator
HV99_RS26480	COG1982	Orn Lys Arg decarboxylase major
HV99_RS26485	COG0189	ligase activity
HV99_RS26490	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS26505	COG0765	amino acid transport
HV99_RS26510	COG0765	amino acid transport
HV99_RS26515	COG1126	abc transporter atp-binding protein
HV99_RS26540	COG1902	pentaerythritol trinitrate reductase activity
HV99_RS26555	COG1253	flavin adenine dinucleotide binding
HV99_RS26560	COG0300	oxidoreductase activity
HV99_RS26570	COG0583	DNA-binding transcription factor activity
HV99_RS26575	COG3591	Belongs to the peptidase S1B family
HV99_RS26575	COG1864	DNA RNA non-specific endonuclease
HV99_RS26580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV99_RS26585	COG4319	ketosteroid isomerase
HV99_RS26600	COG4774	siderophore transport
HV99_RS26645	COG2814	Major facilitator Superfamily
HV99_RS26665	COG0583	DNA-binding transcription factor activity
HV99_RS26675	COG0121	glutamine amidotransferase
HV99_RS26705	COG3712	iron ion homeostasis
HV99_RS26710	COG1595	DNA-templated transcription, initiation
HV99_RS26725	COG1230	cation diffusion facilitator family transporter
HV99_RS26730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV99_RS26790	COG1960	acyl-CoA dehydrogenase activity
HV99_RS26810	COG0406	alpha-ribazole phosphatase activity
HV99_RS26840	COG0778	Nitroreductase
HV99_RS26855	COG4206	TonB-dependent receptor
HV99_RS26865	COG1802	Transcriptional regulator
HV99_RS26875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS26905	COG0477	Major facilitator Superfamily
HV99_RS26925	COG0765	amino acid transport
HV99_RS26935	COG1126	abc transporter atp-binding protein
HV99_RS26945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV99_RS26950	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS27000	COG4191	Histidine kinase
HV99_RS27000	COG0784	Response regulator, receiver
HV99_RS27040	COG1289	transmembrane transporter activity
HV99_RS27055	COG2207	Transcriptional regulator
HV99_RS27075	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV99_RS27080	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV99_RS27090	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV99_RS27115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV99_RS27125	COG0318	PFAM AMP-dependent synthetase and ligase
HV99_RS27130	COG0367	asparagine synthase
HV99_RS27140	COG2211	Major facilitator Superfamily
HV99_RS27190	COG1335	isochorismatase
HV99_RS27195	COG0583	DNA-binding transcription factor activity
HV99_RS27205	COG0791	NLP P60 protein
HV99_RS27210	COG0791	NLP P60 protein
HV99_RS27220	COG3829	transcription factor binding
HV99_RS27235	COG2818	Glycosylase
HV99_RS27260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HV99_RS27265	COG1960	acyl-CoA dehydrogenase activity
HV99_RS27275	COG0625	glutathione transferase activity
HV99_RS27295	COG5001	Diguanylate cyclase
HV99_RS27295	COG5002	protein histidine kinase activity
HV99_RS27295	COG3447	MASE1 domain protein
HV99_RS27315	COG4459	periplasmic nitrate reductase
HV99_RS27320	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV99_RS27320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV99_RS27325	COG3062	negative regulation of establishment of protein localization
HV99_RS27335	COG3043	anaerobic respiration
HV99_RS27340	COG3005	denitrification pathway
HV99_RS27345	COG2951	lytic endotransglycosylase activity
HV99_RS27350	COG0861	Integral membrane protein TerC family
HV99_RS27375	COG2977	Belongs to the P-Pant transferase superfamily
HV99_RS27380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV99_RS27395	COG2226	methyltransferase
HV99_RS27410	COG2205	protein histidine kinase activity
HV99_RS27415	COG0745	RESPONSE REGULATOR receiver
HV99_RS27420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV99_RS27420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV99_RS27430	COG1943	Transposase
HV99_RS27480	COG0531	amino acid
HV99_RS27510	COG0583	DNA-binding transcription factor activity
HV99_RS27515	COG3257	ureidoglycine aminohydrolase activity
HV99_RS27530	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS27530	COG0604	alcohol dehydrogenase
HV99_RS27530	COG3321	synthase
HV99_RS27535	COG2197	response regulator
HV99_RS27575	COG0583	DNA-binding transcription factor activity
HV99_RS27580	COG0667	Aldo Keto reductase
HV99_RS27605	COG0242	peptide deformylase activity
HV99_RS27615	COG2199	diguanylate cyclase activity
HV99_RS27620	COG2885	chlorophyll binding
HV99_RS27650	COG1132	(ABC) transporter
HV99_RS27660	COG4628	conserved protein (DUF2132)
HV99_RS27665	COG2133	pyrroloquinoline quinone binding
HV99_RS27680	COG2207	Transcriptional regulator
HV99_RS27685	COG0477	Major facilitator Superfamily
HV99_RS27700	COG2882	bacterial-type flagellum organization
HV99_RS27755	COG1516	flagellar protein fliS
HV99_RS27760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV99_RS27770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV99_RS27775	COG0438	transferase activity, transferring glycosyl groups
HV99_RS27775	COG1216	Glycosyl transferase, family 2
HV99_RS27780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV99_RS27785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV99_RS27795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HV99_RS27825	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS27830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HV99_RS27850	COG1256	bacterial-type flagellum assembly
HV99_RS27875	COG4787	bacterial-type flagellum-dependent cell motility
HV99_RS27885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HV99_RS27895	COG1815	bacterial-type flagellum-dependent cell motility
HV99_RS27940	COG0326	Molecular chaperone. Has ATPase activity
HV99_RS27955	COG3189	MarR family transcriptional regulator
HV99_RS27975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HV99_RS27990	COG2212	antiporter activity
HV99_RS27995	COG1863	multisubunit Na H antiporter MnhE subunit
HV99_RS28000	COG0651	ATP synthesis coupled electron transport
HV99_RS28005	COG1006	Multisubunit Na H antiporter MnhC subunit
HV99_RS28010	COG2111	Na H antiporter
HV99_RS28010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV99_RS28015	COG3133	Outer membrane lipoprotein
HV99_RS28025	COG1929	Belongs to the glycerate kinase type-1 family
HV99_RS28030	COG2610	gluconate transmembrane transporter activity
HV99_RS28035	COG3835	regulator
HV99_RS28045	COG2885	chlorophyll binding
HV99_RS28060	COG1199	ATP-dependent helicase activity
HV99_RS28100	COG2860	membrane
HV99_RS28115	COG0653	protein targeting
HV99_RS28120	COG0625	glutathione transferase activity
HV99_RS28145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV99_RS28150	COG1012	belongs to the aldehyde dehydrogenase family
HV99_RS28175	COG1960	acyl-CoA dehydrogenase activity
HV99_RS28180	COG1024	Enoyl-CoA hydratase
HV99_RS28185	COG1960	acyl-CoA dehydrogenase activity
HV99_RS28195	COG2814	Major facilitator Superfamily
HV99_RS28200	COG2030	dehydratase
HV99_RS28210	COG0183	Belongs to the thiolase family
HV99_RS28240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HV99_RS28245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV99_RS28260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV99_RS28270	COG0425	Belongs to the sulfur carrier protein TusA family
HV99_RS28325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV99_RS28330	COG3188	usher protein
HV99_RS28350	COG1051	belongs to the nudix hydrolase family
HV99_RS28365	COG1192	Involved in chromosome partitioning
HV99_RS28480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV99_RS28540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV99_RS28630	COG3188	usher protein
HV99_RS28635	COG3121	Chaperone
HV99_RS28795	COG3609	addiction module antidote protein, CC2985 family
HV99_RS28825	COG3046	protein related to deoxyribodipyrimidine photolyase
HV99_RS28835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV99_RS28850	COG4221	oxidoreductase activity
HV99_RS28860	COG1366	Belongs to the anti-sigma-factor antagonist family
HV99_RS28865	COG0789	Transcriptional regulator
HV99_RS28895	COG1024	Enoyl-CoA hydratase
HV99_RS28930	COG1309	transcriptional regulator
HV99_RS28940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV99_RS28965	COG0583	DNA-binding transcription factor activity
HV99_RS28980	COG0667	Aldo Keto reductase
HV99_RS28995	COG1309	transcriptional regulator
HV99_RS29010	COG2814	Major facilitator Superfamily
HV99_RS29015	COG2995	paraquat-inducible protein a
HV99_RS29020	COG2995	paraquat-inducible protein a
HV99_RS29070	COG4774	siderophore transport
HV99_RS29075	COG3712	iron ion homeostasis
HV99_RS29080	COG1595	DNA-templated transcription, initiation
HV99_RS29090	COG3712	iron ion homeostasis
HV99_RS29095	COG1595	DNA-templated transcription, initiation
HV99_RS29115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV99_RS29130	COG0602	queuosine metabolic process
HV99_RS29135	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV99_RS29165	COG0824	Thioesterase
HV99_RS29195	COG0783	Belongs to the Dps family
HV99_RS29240	COG3118	belongs to the thioredoxin family
HV99_RS29275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HV99_RS29290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV99_RS29330	COG3122	Protein conserved in bacteria
HV99_RS29340	COG3956	TIGRFAM MazG family protein
HV99_RS29345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV99_RS29375	COG0784	Response regulator, receiver
HV99_RS29375	COG2205	protein histidine kinase activity
HV99_RS29375	COG5002	protein histidine kinase activity
HV99_RS29380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV99_RS29430	COG3038	cytochrome b561
HV99_RS29445	COG4807	Protein conserved in bacteria
HV99_RS29455	COG2239	Acts as a magnesium transporter
HV99_RS29525	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV99_RS29620	COG2301	Belongs to the HpcH HpaI aldolase family
HV99_RS29630	COG2079	MmgE PrpD family protein
HV99_RS29640	COG1960	acyl-CoA dehydrogenase activity
HV99_RS29645	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HV99_RS29650	COG0583	DNA-binding transcription factor activity
HV99_RS29655	COG0583	DNA-binding transcription factor activity
HV99_RS29705	COG1113	amino acid transport
HV99_RS29725	COG1028	Short-chain dehydrogenase reductase Sdr
HV99_RS29725	COG0604	alcohol dehydrogenase
HV99_RS29725	COG3321	synthase
HV99_RS29755	COG0271	Belongs to the BolA IbaG family
HV99_RS29795	COG0492	ferredoxin-NADP+ reductase activity
HV99_RS29800	COG0450	alkyl hydroperoxide reductase