locus-tag	class	description
B5U27_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B5U27_RS00010	COG0592	DNA-directed DNA polymerase activity
B5U27_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5U27_RS00020	COG0187	DNA topoisomerase II activity
B5U27_RS00025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5U27_RS00095	COG3318	Belongs to the UPF0149 family
B5U27_RS00095	COG3012	SEC-C Motif Domain Protein
B5U27_RS00110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5U27_RS00115	COG0751	glycine-tRNA ligase activity
B5U27_RS00120	COG0752	glycyl-tRNA synthetase alpha subunit
B5U27_RS00125	COG2818	Glycosylase
B5U27_RS00140	COG0243	molybdopterin cofactor binding
B5U27_RS00145	COG0569	domain protein
B5U27_RS00150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5U27_RS00155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5U27_RS00160	COG0242	peptide deformylase activity
B5U27_RS00170	COG0758	DNA mediated transformation
B5U27_RS00175	COG0009	L-threonylcarbamoyladenylate synthase
B5U27_RS00190	COG0408	coproporphyrinogen oxidase activity
B5U27_RS00195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5U27_RS00215	COG3119	arylsulfatase activity
B5U27_RS00220	COG0583	DNA-binding transcription factor activity
B5U27_RS00240	COG0159	tryptophan synthase activity
B5U27_RS00245	COG0133	tryptophan synthase activity
B5U27_RS00260	COG3360	Dodecin
B5U27_RS00270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS00275	COG1764	response to oxidative stress
B5U27_RS00300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B5U27_RS00310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B5U27_RS00325	COG0672	)-iron permease
B5U27_RS00330	COG1280	lysine exporter protein (LysE YggA)
B5U27_RS00340	COG0488	(ABC) transporter
B5U27_RS00375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B5U27_RS00395	COG0181	hydroxymethylbilane synthase activity
B5U27_RS00405	COG2972	Histidine kinase
B5U27_RS00405	COG0745	RESPONSE REGULATOR receiver
B5U27_RS00410	COG0165	Argininosuccinate lyase
B5U27_RS00425	COG0700	Nucleoside recognition
B5U27_RS00435	COG0612	Peptidase, M16
B5U27_RS00440	COG1283	sodium-dependent phosphate transmembrane transporter activity
B5U27_RS00455	COG0583	DNA-binding transcription factor activity
B5U27_RS00460	COG0534	Mate efflux family protein
B5U27_RS00475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5U27_RS00500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B5U27_RS00505	COG4208	sulfate ABC transporter
B5U27_RS00515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B5U27_RS00535	COG2199	diguanylate cyclase activity
B5U27_RS00540	COG0745	RESPONSE REGULATOR receiver
B5U27_RS00545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5U27_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS00625	COG1522	sequence-specific DNA binding
B5U27_RS00655	COG4771	TonB-dependent receptor
B5U27_RS00660	COG4166	transmembrane transport
B5U27_RS00665	COG4174	ABC transporter (Permease)
B5U27_RS00670	COG4239	(ABC) transporter, permease
B5U27_RS00675	COG4172	Belongs to the ABC transporter superfamily
B5U27_RS00685	COG1522	sequence-specific DNA binding
B5U27_RS00695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5U27_RS00700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5U27_RS00740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5U27_RS00745	COG0601	transmembrane transport
B5U27_RS00750	COG0747	negative chemotaxis
B5U27_RS00755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS00830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B5U27_RS00835	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B5U27_RS00840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B5U27_RS00845	COG5001	Diguanylate cyclase
B5U27_RS00845	COG4251	negative regulation of phosphorylation
B5U27_RS00845	COG3706	GGDEF domain
B5U27_RS00845	COG2203	Gaf domain
B5U27_RS00850	COG0189	ligase activity
B5U27_RS00850	COG4067	protein conserved in archaea
B5U27_RS00855	COG0189	ligase activity
B5U27_RS00860	COG1301	dicarboxylic acid transport
B5U27_RS00880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5U27_RS00890	COG1965	Belongs to the frataxin family
B5U27_RS00900	COG0019	diaminopimelate decarboxylase activity
B5U27_RS00905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5U27_RS00915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5U27_RS00930	COG0432	Pfam Uncharacterised protein family UPF0047
B5U27_RS00940	COG0004	ammonium transporteR
B5U27_RS00945	COG0347	Belongs to the P(II) protein family
B5U27_RS00955	COG2960	long-chain fatty acid transporting porin activity
B5U27_RS00965	COG2814	Major facilitator Superfamily
B5U27_RS00975	COG0583	DNA-binding transcription factor activity
B5U27_RS01010	COG2851	Citrate transporter
B5U27_RS01025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B5U27_RS01040	COG0848	biopolymer transport protein
B5U27_RS01050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5U27_RS01065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5U27_RS01070	COG1758	RNA polymerase activity
B5U27_RS01075	COG0194	GDP metabolic process
B5U27_RS01080	COG1561	YicC-like family, N-terminal region
B5U27_RS01085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5U27_RS01095	COG0708	Exodeoxyribonuclease III
B5U27_RS01100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5U27_RS01110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5U27_RS01115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5U27_RS01120	COG0756	dUTP diphosphatase activity
B5U27_RS01125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5U27_RS01130	COG2003	Belongs to the UPF0758 family
B5U27_RS01135	COG0747	negative chemotaxis
B5U27_RS01140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B5U27_RS01145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5U27_RS01175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS01180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5U27_RS01190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS01205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS01215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5U27_RS01230	COG0427	acetyl-CoA hydrolase
B5U27_RS01250	COG1178	ABC-type Fe3 transport system permease component
B5U27_RS01255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5U27_RS01260	COG0509	glycine decarboxylation via glycine cleavage system
B5U27_RS01270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5U27_RS01280	COG1522	sequence-specific DNA binding
B5U27_RS01320	COG2918	glutathione biosynthetic process
B5U27_RS01330	COG2183	response to ionizing radiation
B5U27_RS01365	COG2204	response regulator
B5U27_RS01370	COG5002	protein histidine kinase activity
B5U27_RS01375	COG3023	N-Acetylmuramoyl-L-alanine amidase
B5U27_RS01390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5U27_RS01395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5U27_RS01415	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B5U27_RS01420	COG0735	belongs to the Fur family
B5U27_RS01425	COG1121	(ABC) transporter
B5U27_RS01430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5U27_RS01445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5U27_RS01450	COG2011	ABC-type metal ion transport system permease component
B5U27_RS01455	COG1464	Belongs to the NlpA lipoprotein family
B5U27_RS01465	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B5U27_RS01475	COG0659	secondary active sulfate transmembrane transporter activity
B5U27_RS01490	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B5U27_RS01495	COG0586	Pfam SNARE associated Golgi protein
B5U27_RS01505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5U27_RS01510	COG0248	Ppx GppA phosphatase
B5U27_RS01515	COG1126	abc transporter atp-binding protein
B5U27_RS01520	COG0765	amino acid transport
B5U27_RS01525	COG0765	amino acid transport
B5U27_RS01530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS01535	COG2186	Transcriptional regulator
B5U27_RS01550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B5U27_RS01555	COG0543	2 iron, 2 sulfur cluster binding
B5U27_RS01555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5U27_RS01565	COG2271	Major facilitator Superfamily
B5U27_RS01600	COG4104	PAAR repeat-containing protein
B5U27_RS01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5U27_RS01655	COG2175	clavaminate synthase activity
B5U27_RS01700	COG2271	Major facilitator Superfamily
B5U27_RS01710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5U27_RS01715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5U27_RS01720	COG0006	proline dipeptidase activity
B5U27_RS01725	COG3079	Belongs to the UPF0149 family
B5U27_RS01745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5U27_RS01790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS01795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5U27_RS01805	COG2226	methyltransferase
B5U27_RS01810	COG2011	ABC-type metal ion transport system permease component
B5U27_RS01815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5U27_RS01840	COG2826	transposase and inactivated derivatives, IS30 family
B5U27_RS01850	COG1126	abc transporter atp-binding protein
B5U27_RS01855	COG0765	amino acid transport
B5U27_RS01860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS01865	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B5U27_RS01870	COG1045	serine acetyltransferase
B5U27_RS01890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5U27_RS01900	COG2188	Transcriptional regulator
B5U27_RS01905	COG0402	S-adenosylhomocysteine deaminase activity
B5U27_RS01920	COG3040	lipid binding
B5U27_RS01930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B5U27_RS01945	COG0058	SHG alpha-glucan phosphorylase activity
B5U27_RS01950	COG0596	Alpha beta hydrolase
B5U27_RS01955	COG1490	D-aminoacyl-tRNA deacylase activity
B5U27_RS01960	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B5U27_RS01965	COG2943	transferase activity, transferring hexosyl groups
B5U27_RS01975	COG0840	transmembrane signaling receptor activity
B5U27_RS01980	COG0840	transmembrane signaling receptor activity
B5U27_RS01995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5U27_RS02000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5U27_RS02005	COG0140	phosphoribosyl-ATP diphosphatase activity
B5U27_RS02010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5U27_RS02015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5U27_RS02025	COG2226	methyltransferase
B5U27_RS02070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B5U27_RS02075	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B5U27_RS02085	COG0018	arginyl-trna synthetase
B5U27_RS02090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B5U27_RS02095	COG0254	rRNA binding
B5U27_RS02105	COG0281	malic enzyme
B5U27_RS02145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5U27_RS02150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5U27_RS02165	COG0069	glutamate synthase activity
B5U27_RS02165	COG0070	glutamate synthase
B5U27_RS02165	COG0067	glutamate synthase
B5U27_RS02170	COG0493	'glutamate synthase
B5U27_RS02175	COG0154	amidase activity
B5U27_RS02185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5U27_RS02190	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B5U27_RS02200	COG2610	gluconate transmembrane transporter activity
B5U27_RS02220	COG2814	Major facilitator Superfamily
B5U27_RS02225	COG0583	DNA-binding transcription factor activity
B5U27_RS02235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5U27_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5U27_RS02260	COG2226	methyltransferase
B5U27_RS02285	COG2986	histidine ammonia-lyase
B5U27_RS02300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5U27_RS02310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5U27_RS02315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5U27_RS02330	COG1192	Involved in chromosome partitioning
B5U27_RS02345	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B5U27_RS02350	COG3052	prosthetic group binding
B5U27_RS02370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B5U27_RS02390	COG1272	protein, Hemolysin III
B5U27_RS02395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B5U27_RS02415	COG3038	cytochrome b561
B5U27_RS02420	COG2353	YceI-like domain
B5U27_RS02430	COG0513	Belongs to the DEAD box helicase family
B5U27_RS02435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B5U27_RS02440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B5U27_RS02460	COG3622	Belongs to the hyi family
B5U27_RS02465	COG2610	gluconate transmembrane transporter activity
B5U27_RS02470	COG0235	Class ii aldolase
B5U27_RS02475	COG3395	kinase activity
B5U27_RS02480	COG2084	Dehydrogenase
B5U27_RS02490	COG0436	Aminotransferase
B5U27_RS02495	COG0129	dihydroxy-acid dehydratase activity
B5U27_RS02505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5U27_RS02510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5U27_RS02515	COG2813	Specifically methylates the guanine in position
B5U27_RS02515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5U27_RS02520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5U27_RS02545	COG0791	NLP P60 protein
B5U27_RS02555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5U27_RS02560	COG0540	Belongs to the ATCase OTCase family
B5U27_RS02565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B5U27_RS02570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5U27_RS02575	COG1678	Uncharacterized ACR, COG1678
B5U27_RS02585	COG0189	ligase activity
B5U27_RS02610	COG2198	Histidine kinase
B5U27_RS02610	COG0643	Histidine kinase
B5U27_RS02610	COG0784	Response regulator, receiver
B5U27_RS02625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B5U27_RS02630	COG1802	Transcriptional regulator
B5U27_RS02635	COG1914	H( )-stimulated, divalent metal cation uptake system
B5U27_RS02640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5U27_RS02645	COG4336	lyase activity
B5U27_RS02650	COG1984	allophanate hydrolase subunit 2
B5U27_RS02655	COG4770	biotin carboxylase activity
B5U27_RS02660	COG1196	nuclear chromosome segregation
B5U27_RS02660	COG3264	Mechanosensitive ion channel
B5U27_RS02665	COG3263	regulation of cellular component size
B5U27_RS02675	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS02680	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B5U27_RS02680	COG0506	proline dehydrogenase activity
B5U27_RS02680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B5U27_RS02685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5U27_RS02700	COG1451	nucleotide metabolic process
B5U27_RS02710	COG2153	protein acetylation
B5U27_RS02720	COG1289	transmembrane transporter activity
B5U27_RS02725	COG2081	HI0933 family
B5U27_RS02730	COG0513	Belongs to the DEAD box helicase family
B5U27_RS02745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B5U27_RS02750	COG0859	PFAM glycosyl transferase family 9
B5U27_RS02760	COG0438	transferase activity, transferring glycosyl groups
B5U27_RS02790	COG2192	nodulation
B5U27_RS02795	COG0438	transferase activity, transferring glycosyl groups
B5U27_RS02830	COG1132	(ABC) transporter
B5U27_RS02835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5U27_RS02835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B5U27_RS02845	COG0667	Aldo Keto reductase
B5U27_RS02860	COG1519	Transferase
B5U27_RS02870	COG1538	Outer membrane efflux protein
B5U27_RS02875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B5U27_RS02900	COG0494	nUDIX hydrolase
B5U27_RS02915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B5U27_RS02920	COG3150	esterase
B5U27_RS02935	COG3577	Aspartyl protease
B5U27_RS02965	COG3830	Belongs to the UPF0237 family
B5U27_RS02965	COG0560	Phosphoserine phosphatase
B5U27_RS02975	COG0688	phosphatidylethanolamine metabolic process
B5U27_RS02995	COG1162	GTPase activity
B5U27_RS03000	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B5U27_RS03005	COG2860	membrane
B5U27_RS03015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5U27_RS03015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5U27_RS03020	COG0802	atpase or kinase
B5U27_RS03025	COG0860	N-Acetylmuramoyl-L-alanine amidase
B5U27_RS03030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B5U27_RS03035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5U27_RS03040	COG1923	regulation of RNA biosynthetic process
B5U27_RS03045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5U27_RS03050	COG0330	HflC and HflK could
B5U27_RS03055	COG0330	HflC and HflK could
B5U27_RS03060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B5U27_RS03065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5U27_RS03070	COG0840	transmembrane signaling receptor activity
B5U27_RS03085	COG0557	exoribonuclease II activity
B5U27_RS03090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5U27_RS03095	COG0360	Binds together with S18 to 16S ribosomal RNA
B5U27_RS03100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B5U27_RS03110	COG0359	binds to the 23S rRNA
B5U27_RS03115	COG0305	Participates in initiation and elongation during chromosome replication
B5U27_RS03120	COG1032	radical SAM domain protein
B5U27_RS03135	COG2308	Evidence 4 Homologs of previously reported genes of
B5U27_RS03135	COG2307	Protein conserved in bacteria
B5U27_RS03155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B5U27_RS03160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B5U27_RS03165	COG0583	DNA-binding transcription factor activity
B5U27_RS03200	COG4221	oxidoreductase activity
B5U27_RS03210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5U27_RS03215	COG0142	geranyltranstransferase activity
B5U27_RS03220	COG1722	exodeoxyribonuclease VII activity
B5U27_RS03225	COG0626	cystathionine gamma-synthase activity
B5U27_RS03235	COG0625	glutathione transferase activity
B5U27_RS03265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5U27_RS03315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B5U27_RS03320	COG3228	Belongs to the MtfA family
B5U27_RS03325	COG0586	Pfam SNARE associated Golgi protein
B5U27_RS03330	COG0456	acetyltransferase
B5U27_RS03335	COG4302	ethanolamine ammonia-lyase activity
B5U27_RS03340	COG4303	Ethanolamine ammonia lyase large subunit
B5U27_RS03370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5U27_RS03385	COG0702	epimerase
B5U27_RS03405	COG1346	cytolysis
B5U27_RS03425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5U27_RS03445	COG0183	Belongs to the thiolase family
B5U27_RS03505	COG0583	DNA-binding transcription factor activity
B5U27_RS03515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5U27_RS03530	COG1120	ATPase activity
B5U27_RS03535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5U27_RS03540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5U27_RS03545	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B5U27_RS03550	COG0387	Pfam Sodium calcium exchanger
B5U27_RS03565	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS03570	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS03575	COG3845	ABC transporter
B5U27_RS03585	COG1309	transcriptional regulator
B5U27_RS03590	COG2233	PERMEase
B5U27_RS03640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B5U27_RS03645	COG1074	ATP-dependent DNA helicase activity
B5U27_RS03650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5U27_RS03705	COG3639	organic phosphonate transmembrane transporter activity
B5U27_RS03710	COG3639	organic phosphonate transmembrane transporter activity
B5U27_RS03715	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B5U27_RS03720	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B5U27_RS03725	COG0709	Synthesizes selenophosphate from selenide and ATP
B5U27_RS03730	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B5U27_RS03740	COG2249	NAD(P)H dehydrogenase (quinone) activity
B5U27_RS03745	COG0583	DNA-binding transcription factor activity
B5U27_RS03750	COG0142	geranyltranstransferase activity
B5U27_RS03755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5U27_RS03760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5U27_RS03765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5U27_RS03770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5U27_RS03775	COG3045	CreA protein
B5U27_RS03785	COG0268	Binds directly to 16S ribosomal RNA
B5U27_RS03795	COG0196	riboflavin kinase activity
B5U27_RS03800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B5U27_RS03805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5U27_RS03810	COG1047	Peptidyl-prolyl cis-trans
B5U27_RS03815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5U27_RS03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS03920	COG0542	response to heat
B5U27_RS04010	COG2433	Pfam Transposase IS66
B5U27_RS04170	COG2433	Pfam Transposase IS66
B5U27_RS04230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5U27_RS04245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5U27_RS04265	COG0629	single-stranded DNA binding
B5U27_RS04335	COG0305	Participates in initiation and elongation during chromosome replication
B5U27_RS04340	COG2894	cell division
B5U27_RS04390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS04420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5U27_RS04435	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS04445	COG1879	ABC-type sugar transport system periplasmic component
B5U27_RS04450	COG1609	Transcriptional regulator
B5U27_RS04480	COG2201	protein-glutamate methylesterase activity
B5U27_RS04485	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B5U27_RS04495	COG0835	chemotaxis
B5U27_RS04500	COG0840	transmembrane signaling receptor activity
B5U27_RS04505	COG0643	Histidine kinase
B5U27_RS04505	COG2198	Histidine kinase
B5U27_RS04525	COG1252	NADH dehydrogenase
B5U27_RS04555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B5U27_RS04560	COG0237	dephospho-CoA kinase activity
B5U27_RS04590	COG2826	transposase and inactivated derivatives, IS30 family
B5U27_RS04630	COG1358	cellular component organization or biogenesis
B5U27_RS04675	COG2304	oxidoreductase activity
B5U27_RS04695	COG3023	N-Acetylmuramoyl-L-alanine amidase
B5U27_RS04705	COG0084	hydrolase, TatD family'
B5U27_RS04710	COG1609	Transcriptional regulator
B5U27_RS04720	COG1105	Belongs to the carbohydrate kinase PfkB family
B5U27_RS04725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B5U27_RS04725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5U27_RS04725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5U27_RS04740	COG0166	Belongs to the GPI family
B5U27_RS04745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B5U27_RS04750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B5U27_RS04765	COG2204	response regulator
B5U27_RS04770	COG4191	Histidine kinase
B5U27_RS04780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5U27_RS04795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B5U27_RS04805	COG1489	DNA binding
B5U27_RS04815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5U27_RS04830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5U27_RS04850	COG0028	Belongs to the TPP enzyme family
B5U27_RS04860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5U27_RS04865	COG1183	phosphatidylcholine synthase activity
B5U27_RS04870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5U27_RS04875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B5U27_RS04950	COG0288	reversible hydration of carbon dioxide
B5U27_RS04960	COG1418	mRNA catabolic process
B5U27_RS04970	COG2824	Alkylphosphonate utilization operon protein PhnA
B5U27_RS04975	COG3011	Protein conserved in bacteria
B5U27_RS04980	COG2814	Major facilitator Superfamily
B5U27_RS05005	COG2203	Gaf domain
B5U27_RS05005	COG3706	GGDEF domain
B5U27_RS05005	COG5001	Diguanylate cyclase
B5U27_RS05005	COG4251	negative regulation of phosphorylation
B5U27_RS05025	COG1335	isochorismatase
B5U27_RS05030	COG3540	Alkaline phosphatase
B5U27_RS05055	COG0811	peptide transport
B5U27_RS05065	COG1247	-acetyltransferase
B5U27_RS05080	COG1215	transferase activity, transferring glycosyl groups
B5U27_RS05085	COG1215	transferase activity, transferring glycosyl groups
B5U27_RS05090	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B5U27_RS05095	COG0457	Tetratricopeptide repeat
B5U27_RS05120	COG5654	RES domain protein
B5U27_RS05125	COG5642	Protein of unknown function (DUF2384)
B5U27_RS05130	COG2204	response regulator
B5U27_RS05140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5U27_RS05150	COG1595	DNA-templated transcription, initiation
B5U27_RS05180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5U27_RS05190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5U27_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS05210	COG0840	transmembrane signaling receptor activity
B5U27_RS05215	COG0840	transmembrane signaling receptor activity
B5U27_RS05225	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B5U27_RS05255	COG2433	Pfam Transposase IS66
B5U27_RS05290	COG0582	viral genome integration into host DNA
B5U27_RS05365	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B5U27_RS05415	COG0469	pyruvate kinase activity
B5U27_RS05435	COG0714	Associated with various cellular activities
B5U27_RS05475	COG2925	Exonuclease
B5U27_RS05485	COG0788	formyltetrahydrofolate deformylase activity
B5U27_RS05495	COG0306	phosphate transporter
B5U27_RS05505	COG1414	Transcriptional regulator
B5U27_RS05510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B5U27_RS05515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B5U27_RS05520	COG0183	Belongs to the thiolase family
B5U27_RS05525	COG0477	Major facilitator Superfamily
B5U27_RS05535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5U27_RS05540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS05580	COG0477	Major facilitator Superfamily
B5U27_RS05590	COG0443	Heat shock 70 kDa protein
B5U27_RS05595	COG4191	Histidine kinase
B5U27_RS05595	COG0784	Response regulator, receiver
B5U27_RS05605	COG4191	Histidine kinase
B5U27_RS05640	COG1454	alcohol dehydrogenase
B5U27_RS05660	COG1238	metal cluster binding
B5U27_RS05700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B5U27_RS05750	COG1484	DNA-dependent DNA replication
B5U27_RS05820	COG4695	Portal protein
B5U27_RS05925	COG3179	chitinase
B5U27_RS05955	COG0582	viral genome integration into host DNA
B5U27_RS05965	COG2267	carboxylic ester hydrolase activity
B5U27_RS05990	COG0439	Biotin carboxylase
B5U27_RS05995	COG3665	Urea carboxylase-associated protein
B5U27_RS06005	COG1116	anion transmembrane transporter activity
B5U27_RS06005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS06030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5U27_RS06080	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B5U27_RS06110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5U27_RS06115	COG0481	GTPase activity
B5U27_RS06120	COG0681	Belongs to the peptidase S26 family
B5U27_RS06130	COG0571	ribonuclease III activity
B5U27_RS06135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B5U27_RS06140	COG1381	Involved in DNA repair and RecF pathway recombination
B5U27_RS06145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B5U27_RS06150	COG0500	methyltransferase
B5U27_RS06155	COG2226	methyltransferase
B5U27_RS06165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5U27_RS06195	COG2188	Transcriptional regulator
B5U27_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS06230	COG0523	cobalamin synthesis protein
B5U27_RS06260	COG4628	conserved protein (DUF2132)
B5U27_RS06270	COG2375	cellular response to nickel ion
B5U27_RS06275	COG1695	Transcriptional regulator
B5U27_RS06325	COG0254	rRNA binding
B5U27_RS06330	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5U27_RS06340	COG0583	DNA-binding transcription factor activity
B5U27_RS06345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B5U27_RS06350	COG0596	Alpha beta hydrolase
B5U27_RS06375	COG1126	abc transporter atp-binding protein
B5U27_RS06380	COG0765	amino acid transport
B5U27_RS06385	COG0765	amino acid transport
B5U27_RS06405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5U27_RS06415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B5U27_RS06420	COG3842	ATPase activity
B5U27_RS06435	COG0243	molybdopterin cofactor binding
B5U27_RS06440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B5U27_RS06455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5U27_RS06460	COG0418	dihydroorotase activity
B5U27_RS06470	COG0137	argininosuccinate synthase activity
B5U27_RS06485	COG2197	response regulator
B5U27_RS06495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5U27_RS06500	COG2878	Part of a membrane complex involved in electron transport
B5U27_RS06505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5U27_RS06505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5U27_RS06510	COG0489	protein tyrosine kinase activity
B5U27_RS06515	COG1278	Cold shock
B5U27_RS06520	COG0717	Belongs to the dCTP deaminase family
B5U27_RS06535	COG1201	RNA secondary structure unwinding
B5U27_RS06570	COG1793	dna ligase
B5U27_RS06575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5U27_RS06575	COG1793	dna ligase
B5U27_RS06585	COG2366	antibiotic biosynthetic process
B5U27_RS06590	COG0653	protein targeting
B5U27_RS06630	COG3012	SEC-C Motif Domain Protein
B5U27_RS06665	COG1199	ATP-dependent helicase activity
B5U27_RS06670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B5U27_RS06680	COG0259	pyridoxamine-phosphate oxidase activity
B5U27_RS06690	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B5U27_RS06740	COG2271	Major facilitator Superfamily
B5U27_RS06775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5U27_RS06795	COG2030	dehydratase
B5U27_RS06800	COG0318	PFAM AMP-dependent synthetase and ligase
B5U27_RS06820	COG1643	Atp-dependent helicase
B5U27_RS06845	COG1132	(ABC) transporter
B5U27_RS06855	COG2267	carboxylic ester hydrolase activity
B5U27_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS06960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5U27_RS06985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5U27_RS07010	COG2814	Major facilitator Superfamily
B5U27_RS07045	COG0657	acetylesterase activity
B5U27_RS07050	COG3958	Transketolase
B5U27_RS07055	COG3959	Transketolase, thiamine diphosphate binding domain
B5U27_RS07060	COG2271	Major facilitator Superfamily
B5U27_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS07070	COG0583	DNA-binding transcription factor activity
B5U27_RS07100	COG3781	membrane
B5U27_RS07140	COG0741	lytic transglycosylase activity
B5U27_RS07140	COG1388	LysM domain
B5U27_RS07210	COG4792	protein secretion
B5U27_RS07220	COG4794	Type iii secretion
B5U27_RS07375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B5U27_RS07380	COG0343	queuine tRNA-ribosyltransferase activity
B5U27_RS07385	COG1862	Preprotein translocase
B5U27_RS07400	COG3134	Outer membrane lipoprotein
B5U27_RS07415	COG1045	serine acetyltransferase
B5U27_RS07430	COG1104	cysteine desulfurase activity
B5U27_RS07440	COG0316	Belongs to the HesB IscA family
B5U27_RS07445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B5U27_RS07450	COG0443	Heat shock 70 kDa protein
B5U27_RS07455	COG0633	Ferredoxin
B5U27_RS07465	COG0105	UTP biosynthetic process
B5U27_RS07470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B5U27_RS07485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5U27_RS07490	COG0124	histidyl-tRNA synthetase
B5U27_RS07505	COG1160	GTP binding
B5U27_RS07510	COG0436	Aminotransferase
B5U27_RS07530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5U27_RS07535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5U27_RS07540	COG0739	heme binding
B5U27_RS07545	COG1570	exodeoxyribonuclease VII activity
B5U27_RS07560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5U27_RS07560	COG0519	Catalyzes the synthesis of GMP from XMP
B5U27_RS07590	COG0590	tRNA wobble adenosine to inosine editing
B5U27_RS07595	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B5U27_RS07600	COG0047	phosphoribosylformylglycinamidine synthase activity
B5U27_RS07600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5U27_RS07620	COG0494	nUDIX hydrolase
B5U27_RS07640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B5U27_RS07645	COG0477	Major facilitator Superfamily
B5U27_RS07650	COG4536	flavin adenine dinucleotide binding
B5U27_RS07660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5U27_RS07665	COG0228	four-way junction DNA binding
B5U27_RS07670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5U27_RS07675	COG0336	Belongs to the RNA methyltransferase TrmD family
B5U27_RS07680	COG0335	large ribosomal subunit rRNA binding
B5U27_RS07685	COG4974	Belongs to the 'phage' integrase family
B5U27_RS07690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5U27_RS07705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS07705	COG2205	protein histidine kinase activity
B5U27_RS07715	COG2197	response regulator
B5U27_RS07740	COG1902	pentaerythritol trinitrate reductase activity
B5U27_RS07770	COG0457	Tetratricopeptide repeat
B5U27_RS07770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5U27_RS07785	COG2201	protein-glutamate methylesterase activity
B5U27_RS07790	COG5001	Diguanylate cyclase
B5U27_RS07790	COG4251	negative regulation of phosphorylation
B5U27_RS07790	COG3706	GGDEF domain
B5U27_RS07790	COG2203	Gaf domain
B5U27_RS07795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B5U27_RS07800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B5U27_RS07815	COG1073	alpha beta
B5U27_RS07825	COG3047	cAMP biosynthetic process
B5U27_RS07825	COG2885	chlorophyll binding
B5U27_RS07835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B5U27_RS07840	COG0563	adenylate kinase activity
B5U27_RS07870	COG0742	ribosomal rna small subunit methyltransferase
B5U27_RS07885	COG2937	Belongs to the GPAT DAPAT family
B5U27_RS07895	COG2226	methyltransferase
B5U27_RS07900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5U27_RS07905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B5U27_RS07910	COG2166	iron-sulfur cluster assembly
B5U27_RS07915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5U27_RS07920	COG2171	N-acyltransferase activity
B5U27_RS07925	COG1393	Belongs to the ArsC family
B5U27_RS07940	COG0436	Aminotransferase
B5U27_RS07945	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B5U27_RS07950	COG0024	Methionine aminopeptidase
B5U27_RS07955	COG0052	Belongs to the universal ribosomal protein uS2 family
B5U27_RS07960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5U27_RS07965	COG0528	UMP kinase activity
B5U27_RS07970	COG0233	cytoplasmic translational termination
B5U27_RS07975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5U27_RS07985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5U27_RS07995	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5U27_RS08005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5U27_RS08010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5U27_RS08015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5U27_RS08020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5U27_RS08025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5U27_RS08030	COG0587	DNA-directed DNA polymerase activity
B5U27_RS08035	COG0825	malonyl-CoA metabolic process
B5U27_RS08040	COG0037	tRNA processing
B5U27_RS08045	COG0504	CTP synthase activity
B5U27_RS08050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B5U27_RS08055	COG0148	phosphopyruvate hydratase activity
B5U27_RS08065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5U27_RS08075	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B5U27_RS08080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5U27_RS08085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B5U27_RS08090	COG0585	pseudouridine synthase activity
B5U27_RS08095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5U27_RS08100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5U27_RS08115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5U27_RS08120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B5U27_RS08125	COG1546	Belongs to the CinA family
B5U27_RS08130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5U27_RS08135	COG2137	regulation of response to DNA damage stimulus
B5U27_RS08150	COG3148	PFAM DTW domain containing protein
B5U27_RS08170	COG0583	DNA-binding transcription factor activity
B5U27_RS08185	COG4807	Protein conserved in bacteria
B5U27_RS08190	COG1187	pseudouridine synthase activity
B5U27_RS08200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5U27_RS08265	COG4695	Portal protein
B5U27_RS08400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5U27_RS08415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5U27_RS08460	COG3158	transport of potassium into the cell
B5U27_RS08490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5U27_RS08500	COG0442	prolyl-tRNA aminoacylation
B5U27_RS08520	COG2900	Belongs to the SlyX family
B5U27_RS08535	COG0783	Belongs to the Dps family
B5U27_RS08545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5U27_RS08550	COG0217	transcriptional regulatory protein
B5U27_RS08555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B5U27_RS08560	COG0632	four-way junction helicase activity
B5U27_RS08565	COG2255	four-way junction helicase activity
B5U27_RS08570	COG0824	Thioesterase
B5U27_RS08590	COG0823	Involved in the tonB-independent uptake of proteins
B5U27_RS08595	COG2885	chlorophyll binding
B5U27_RS08600	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B5U27_RS08605	COG0602	queuosine metabolic process
B5U27_RS08610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5U27_RS08640	COG1063	alcohol dehydrogenase
B5U27_RS08645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5U27_RS08650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5U27_RS08930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5U27_RS08980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5U27_RS09000	COG0629	single-stranded DNA binding
B5U27_RS09075	COG0305	Participates in initiation and elongation during chromosome replication
B5U27_RS09080	COG2894	cell division
B5U27_RS09090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5U27_RS09100	COG0425	Belongs to the sulfur carrier protein TusA family
B5U27_RS09110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5U27_RS09120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5U27_RS09125	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B5U27_RS09130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B5U27_RS09135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5U27_RS09165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5U27_RS09170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B5U27_RS09255	COG2932	Transcriptional regulator
B5U27_RS09485	COG3179	chitinase
B5U27_RS09615	COG2135	peptidase activity
B5U27_RS09670	COG2433	Pfam Transposase IS66
B5U27_RS09855	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B5U27_RS09940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5U27_RS10005	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B5U27_RS10030	COG0281	malic enzyme
B5U27_RS10035	COG2194	sulfuric ester hydrolase activity
B5U27_RS10045	COG3100	YcgL domain-containing protein
B5U27_RS10060	COG2983	Belongs to the UPF0260 family
B5U27_RS10075	COG3667	copper resistance
B5U27_RS10080	COG2132	Multicopper oxidase
B5U27_RS10095	COG1770	oligopeptidase
B5U27_RS10105	COG0121	glutamine amidotransferase
B5U27_RS10120	COG0542	response to heat
B5U27_RS10140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B5U27_RS10150	COG2205	protein histidine kinase activity
B5U27_RS10170	COG1349	DNA-binding transcription factor activity
B5U27_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS10190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5U27_RS10195	COG3395	kinase activity
B5U27_RS10200	COG1454	alcohol dehydrogenase
B5U27_RS10205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5U27_RS10210	COG2271	Major facilitator Superfamily
B5U27_RS10225	COG1611	Belongs to the LOG family
B5U27_RS10230	COG4991	sh3 domain protein
B5U27_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS10255	COG0110	maltose O-acetyltransferase activity
B5U27_RS10260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5U27_RS10265	COG1216	Glycosyl transferase, family 2
B5U27_RS10265	COG0438	transferase activity, transferring glycosyl groups
B5U27_RS10285	COG0477	Major facilitator Superfamily
B5U27_RS10290	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B5U27_RS10310	COG0835	chemotaxis
B5U27_RS10310	COG0784	Response regulator, receiver
B5U27_RS10315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5U27_RS10320	COG0583	DNA-binding transcription factor activity
B5U27_RS10325	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B5U27_RS10335	COG1815	bacterial-type flagellum-dependent cell motility
B5U27_RS10345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B5U27_RS10365	COG4787	bacterial-type flagellum-dependent cell motility
B5U27_RS10375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B5U27_RS10380	COG1706	bacterial-type flagellum-dependent cell motility
B5U27_RS10400	COG1216	Glycosyl transferase, family 2
B5U27_RS10400	COG0438	transferase activity, transferring glycosyl groups
B5U27_RS10405	COG1216	Glycosyl transferase, family 2
B5U27_RS10405	COG0438	transferase activity, transferring glycosyl groups
B5U27_RS10410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5U27_RS10425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B5U27_RS10455	COG1677	Flagellar hook-basal body complex protein FliE
B5U27_RS10490	COG0745	RESPONSE REGULATOR receiver
B5U27_RS10535	COG1987	bacterial-type flagellum assembly
B5U27_RS10545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5U27_RS10555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5U27_RS10580	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B5U27_RS10585	COG2198	Histidine kinase
B5U27_RS10585	COG0784	Response regulator, receiver
B5U27_RS10585	COG0643	Histidine kinase
B5U27_RS10590	COG2201	protein-glutamate methylesterase activity
B5U27_RS10595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5U27_RS10605	COG1192	Involved in chromosome partitioning
B5U27_RS10615	COG0835	chemotaxis
B5U27_RS10630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5U27_RS10635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5U27_RS10690	COG2010	Cytochrome c
B5U27_RS10705	COG3278	Belongs to the heme-copper respiratory oxidase family
B5U27_RS10725	COG2826	transposase and inactivated derivatives, IS30 family
B5U27_RS10750	COG2826	transposase and inactivated derivatives, IS30 family
B5U27_RS10760	COG0840	transmembrane signaling receptor activity
B5U27_RS10775	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B5U27_RS10825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B5U27_RS10830	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5U27_RS10840	COG4133	protoheme IX ABC transporter activity
B5U27_RS10860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B5U27_RS10865	COG1138	Cytochrome C-type biogenesis protein
B5U27_RS10895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5U27_RS10910	COG1566	PFAM secretion protein HlyD family protein
B5U27_RS10920	COG1289	transmembrane transporter activity
B5U27_RS10955	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
B5U27_RS10960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5U27_RS10990	COG2837	iron assimilation
B5U27_RS10995	COG2822	iron ion transport
B5U27_RS11000	COG0672	)-iron permease
B5U27_RS11005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B5U27_RS11010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5U27_RS11010	COG2169	Transcriptional regulator
B5U27_RS11020	COG0659	secondary active sulfate transmembrane transporter activity
B5U27_RS11025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5U27_RS11035	COG2223	nitrite transmembrane transporter activity
B5U27_RS11050	COG0583	DNA-binding transcription factor activity
B5U27_RS11060	COG0784	Response regulator, receiver
B5U27_RS11060	COG4191	Histidine kinase
B5U27_RS11140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B5U27_RS11150	COG3265	gluconokinase activity
B5U27_RS11155	COG1609	Transcriptional regulator
B5U27_RS11165	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B5U27_RS11170	COG0247	lactate metabolic process
B5U27_RS11175	COG0277	FAD linked oxidase domain protein
B5U27_RS11180	COG0277	FAD linked oxidase domain protein
B5U27_RS11200	COG2203	Gaf domain
B5U27_RS11200	COG5001	Diguanylate cyclase
B5U27_RS11200	COG4251	negative regulation of phosphorylation
B5U27_RS11200	COG3706	GGDEF domain
B5U27_RS11210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B5U27_RS11215	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5U27_RS11230	COG2807	transmembrane transport
B5U27_RS11275	COG0583	DNA-binding transcription factor activity
B5U27_RS11280	COG0728	peptidoglycan biosynthetic process
B5U27_RS11330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5U27_RS11340	COG1597	lipid kinase activity
B5U27_RS11345	COG2197	response regulator
B5U27_RS11360	COG0633	Ferredoxin
B5U27_RS11360	COG3217	Mosc domain protein beta barrel domain protein
B5U27_RS11365	COG0741	lytic transglycosylase activity
B5U27_RS11370	COG0488	(ABC) transporter
B5U27_RS11375	COG0589	response to stress
B5U27_RS11395	COG1024	Enoyl-CoA hydratase
B5U27_RS11395	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5U27_RS11400	COG0183	Belongs to the thiolase family
B5U27_RS11430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5U27_RS11450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B5U27_RS11460	COG3568	Endonuclease Exonuclease Phosphatase
B5U27_RS11465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS11470	COG0392	lysyltransferase activity
B5U27_RS11480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5U27_RS11490	COG3718	enzyme involved in inositol metabolism
B5U27_RS11505	COG3962	Belongs to the TPP enzyme family
B5U27_RS11510	COG0673	inositol 2-dehydrogenase activity
B5U27_RS11515	COG1082	Xylose isomerase domain protein TIM barrel
B5U27_RS11520	COG0673	inositol 2-dehydrogenase activity
B5U27_RS11535	COG1129	ABC transporter
B5U27_RS11540	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS11570	COG1320	monovalent cation:proton antiporter activity
B5U27_RS11575	COG2212	antiporter activity
B5U27_RS11585	COG0651	ATP synthesis coupled electron transport
B5U27_RS11590	COG1006	Multisubunit Na H antiporter MnhC subunit
B5U27_RS11595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B5U27_RS11595	COG2111	Na H antiporter
B5U27_RS11615	COG3829	transcription factor binding
B5U27_RS11620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS11625	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B5U27_RS11635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS11645	COG0584	glycerophosphoryl diester phosphodiesterase
B5U27_RS11650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5U27_RS11655	COG0504	CTP synthase activity
B5U27_RS11660	COG2329	Antibiotic biosynthesis monooxygenase
B5U27_RS11665	COG2031	fatty acid transporter
B5U27_RS11675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B5U27_RS11680	COG0583	DNA-binding transcription factor activity
B5U27_RS11695	COG0431	NADPH-dependent FMN reductase
B5U27_RS11700	COG1596	polysaccharide export
B5U27_RS11705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5U27_RS11710	COG0297	glycogen (starch) synthase activity
B5U27_RS11740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5U27_RS11760	COG1104	cysteine desulfurase activity
B5U27_RS11810	COG0720	synthase
B5U27_RS11840	COG0628	permease
B5U27_RS11870	COG0713	ATP synthesis coupled electron transport
B5U27_RS11880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5U27_RS11885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B5U27_RS11890	COG1034	ATP synthesis coupled electron transport
B5U27_RS11905	COG0649	NAD binding
B5U27_RS11905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5U27_RS11910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5U27_RS11915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5U27_RS11930	COG2153	protein acetylation
B5U27_RS11935	COG2850	peptidyl-arginine hydroxylation
B5U27_RS11945	COG2915	High frequency lysogenization protein hflD homolog
B5U27_RS11950	COG0482	sulfurtransferase activity
B5U27_RS11965	COG1278	Cold shock
B5U27_RS11970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B5U27_RS11975	COG0542	response to heat
B5U27_RS11980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5U27_RS11985	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B5U27_RS11990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B5U27_RS12000	COG1674	ftsk spoiiie
B5U27_RS12005	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B5U27_RS12010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5U27_RS12015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5U27_RS12020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B5U27_RS12025	COG1648	precorrin-2 dehydrogenase activity
B5U27_RS12025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5U27_RS12030	COG0435	Glutathione S-transferase
B5U27_RS12035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5U27_RS12070	COG0583	DNA-binding transcription factor activity
B5U27_RS12115	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS12120	COG0583	DNA-binding transcription factor activity
B5U27_RS12140	COG1472	Belongs to the glycosyl hydrolase 3 family
B5U27_RS12150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5U27_RS12155	COG1459	type II secretion system
B5U27_RS12160	COG2165	general secretion pathway protein
B5U27_RS12165	COG2165	general secretion pathway protein
B5U27_RS12180	COG3156	type II secretion system protein K
B5U27_RS12200	COG1450	Type ii and iii secretion system protein
B5U27_RS12215	COG2814	Major facilitator Superfamily
B5U27_RS12225	COG2814	Major facilitator Superfamily
B5U27_RS12235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5U27_RS12240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS12255	COG5002	protein histidine kinase activity
B5U27_RS12260	COG0745	RESPONSE REGULATOR receiver
B5U27_RS12265	COG2116	formate transmembrane transporter activity
B5U27_RS12300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5U27_RS12310	COG4172	Belongs to the ABC transporter superfamily
B5U27_RS12315	COG4239	(ABC) transporter, permease
B5U27_RS12320	COG4174	ABC transporter (Permease)
B5U27_RS12330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5U27_RS12335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5U27_RS12350	COG2197	response regulator
B5U27_RS12355	COG0322	excinuclease ABC activity
B5U27_RS12380	COG0673	inositol 2-dehydrogenase activity
B5U27_RS12390	COG1609	Transcriptional regulator
B5U27_RS12430	COG1126	abc transporter atp-binding protein
B5U27_RS12435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS12440	COG1231	oxidoreductase activity
B5U27_RS12460	COG4214	carbohydrate transport
B5U27_RS12465	COG1129	ABC transporter
B5U27_RS12470	COG4213	ABC transporter substrate-binding protein
B5U27_RS12475	COG2115	Belongs to the xylose isomerase family
B5U27_RS12480	COG1609	Transcriptional regulator
B5U27_RS12480	COG2207	Transcriptional regulator
B5U27_RS12510	COG1129	ABC transporter
B5U27_RS12515	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS12520	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS12530	COG1022	Amp-dependent synthetase and ligase
B5U27_RS12590	COG0745	RESPONSE REGULATOR receiver
B5U27_RS12595	COG2205	protein histidine kinase activity
B5U27_RS12630	COG1335	isochorismatase
B5U27_RS12645	COG3397	chitin binding
B5U27_RS12705	COG1476	TRANSCRIPTIONal
B5U27_RS12715	COG3617	BRO family, N-terminal domain
B5U27_RS12740	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B5U27_RS12755	COG2070	2-Nitropropane dioxygenase
B5U27_RS12760	COG1309	transcriptional regulator
B5U27_RS12765	COG0604	alcohol dehydrogenase
B5U27_RS12775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5U27_RS12785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5U27_RS12790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS12790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5U27_RS12800	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B5U27_RS12815	COG1280	lysine exporter protein (LysE YggA)
B5U27_RS12830	COG4977	sequence-specific DNA binding
B5U27_RS12880	COG2814	Major facilitator Superfamily
B5U27_RS12895	COG1024	Enoyl-CoA hydratase
B5U27_RS12900	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS12905	COG3320	Male sterility
B5U27_RS12905	COG1022	Amp-dependent synthetase and ligase
B5U27_RS12925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5U27_RS12935	COG1984	allophanate hydrolase subunit 2
B5U27_RS12945	COG0667	Aldo Keto reductase
B5U27_RS12985	COG4948	Mandelate Racemase Muconate Lactonizing
B5U27_RS12995	COG0583	DNA-binding transcription factor activity
B5U27_RS13005	COG1957	nucleoside hydrolase
B5U27_RS13010	COG5001	Diguanylate cyclase
B5U27_RS13040	COG1917	Cupin 2, conserved barrel domain protein
B5U27_RS13040	COG1396	sequence-specific DNA binding
B5U27_RS13065	COG0784	Response regulator, receiver
B5U27_RS13065	COG4191	Histidine kinase
B5U27_RS13085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B5U27_RS13095	COG2076	Multidrug Resistance protein
B5U27_RS13100	COG2076	Multidrug Resistance protein
B5U27_RS13105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B5U27_RS13110	COG0726	polysaccharide deacetylase
B5U27_RS13115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5U27_RS13115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5U27_RS13120	COG0463	Glycosyl transferase, family 2
B5U27_RS13125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5U27_RS13270	COG2390	Transcriptional regulator
B5U27_RS13275	COG0698	ribose 5-phosphate isomerase
B5U27_RS13280	COG1129	ABC transporter
B5U27_RS13285	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS13290	COG1879	ABC-type sugar transport system periplasmic component
B5U27_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS13300	COG1063	alcohol dehydrogenase
B5U27_RS13305	COG2376	Dihydroxyacetone kinase
B5U27_RS13400	COG0019	diaminopimelate decarboxylase activity
B5U27_RS13410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B5U27_RS13425	COG0747	negative chemotaxis
B5U27_RS13435	COG0444	Belongs to the ABC transporter superfamily
B5U27_RS13445	COG0601	transmembrane transport
B5U27_RS13450	COG2072	flavoprotein involved in K transport
B5U27_RS13470	COG0247	lactate metabolic process
B5U27_RS13470	COG0277	FAD linked oxidase domain protein
B5U27_RS13475	COG0583	DNA-binding transcription factor activity
B5U27_RS13480	COG0583	DNA-binding transcription factor activity
B5U27_RS13490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B5U27_RS13505	COG0189	ligase activity
B5U27_RS13510	COG0598	Magnesium transport protein CorA
B5U27_RS13520	COG0587	DNA-directed DNA polymerase activity
B5U27_RS13535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5U27_RS13540	COG0667	Aldo Keto reductase
B5U27_RS13550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS13555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5U27_RS13560	COG1116	anion transmembrane transporter activity
B5U27_RS13575	COG0210	DNA helicase
B5U27_RS13580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5U27_RS13600	COG1126	abc transporter atp-binding protein
B5U27_RS13605	COG0765	amino acid transport
B5U27_RS13610	COG0765	amino acid transport
B5U27_RS13655	COG0488	(ABC) transporter
B5U27_RS13660	COG2706	6-phosphogluconolactonase activity
B5U27_RS13675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B5U27_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS13710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5U27_RS13730	COG0583	DNA-binding transcription factor activity
B5U27_RS13740	COG0729	surface antigen
B5U27_RS13750	COG0708	Exodeoxyribonuclease III
B5U27_RS13755	COG2885	chlorophyll binding
B5U27_RS13760	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS13770	COG0789	Transcriptional regulator
B5U27_RS13785	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS13790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5U27_RS13795	COG1024	Enoyl-CoA hydratase
B5U27_RS13805	COG0316	Belongs to the HesB IscA family
B5U27_RS13805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5U27_RS13810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B5U27_RS13825	COG1879	ABC-type sugar transport system periplasmic component
B5U27_RS13840	COG0616	signal peptide processing
B5U27_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS13875	COG2816	NAD+ diphosphatase activity
B5U27_RS13880	COG1024	Enoyl-CoA hydratase
B5U27_RS13885	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B5U27_RS13900	COG0784	Response regulator, receiver
B5U27_RS13900	COG2205	protein histidine kinase activity
B5U27_RS13910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5U27_RS13920	COG0745	RESPONSE REGULATOR receiver
B5U27_RS13940	COG1653	transport
B5U27_RS13945	COG1175	transmembrane transport
B5U27_RS13960	COG0246	Mannitol dehydrogenase
B5U27_RS13965	COG1070	Carbohydrate kinase
B5U27_RS13990	COG1064	alcohol dehydrogenase
B5U27_RS14015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS14030	COG1253	flavin adenine dinucleotide binding
B5U27_RS14040	COG0583	DNA-binding transcription factor activity
B5U27_RS14045	COG2814	Major facilitator Superfamily
B5U27_RS14055	COG3132	Protein of unknown function, DUF480
B5U27_RS14060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5U27_RS14080	COG1686	Belongs to the peptidase S11 family
B5U27_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS14110	COG2267	carboxylic ester hydrolase activity
B5U27_RS14115	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS14140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5U27_RS14145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5U27_RS14150	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5U27_RS14160	COG3842	ATPase activity
B5U27_RS14165	COG0583	DNA-binding transcription factor activity
B5U27_RS14175	COG0583	DNA-binding transcription factor activity
B5U27_RS14180	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS14185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B5U27_RS14195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B5U27_RS14200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5U27_RS14205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B5U27_RS14210	COG2080	2 iron, 2 sulfur cluster binding
B5U27_RS14215	COG0579	oxidoreductase
B5U27_RS14220	COG4251	negative regulation of phosphorylation
B5U27_RS14245	COG4792	protein secretion
B5U27_RS14250	COG4791	protein targeting
B5U27_RS14260	COG4790	Type iii secretion
B5U27_RS14265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5U27_RS14290	COG4669	(LipO)protein
B5U27_RS14320	COG4964	Belongs to the GSP D family
B5U27_RS14325	COG4789	Type iii secretion
B5U27_RS14370	COG3713	MltA-interacting MipA family protein
B5U27_RS14375	COG0745	RESPONSE REGULATOR receiver
B5U27_RS14380	COG5002	protein histidine kinase activity
B5U27_RS14395	COG1609	Transcriptional regulator
B5U27_RS14400	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS14405	COG1129	ABC transporter
B5U27_RS14410	COG1879	ABC-type sugar transport system periplasmic component
B5U27_RS14415	COG3386	PFAM SMP-30 Gluconolaconase
B5U27_RS14425	COG0803	Belongs to the bacterial solute-binding protein 9 family
B5U27_RS14435	COG1121	(ABC) transporter
B5U27_RS14450	COG1126	abc transporter atp-binding protein
B5U27_RS14455	COG0765	amino acid transport
B5U27_RS14460	COG0765	amino acid transport
B5U27_RS14470	COG0277	FAD linked oxidase domain protein
B5U27_RS14475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS14480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B5U27_RS14485	COG0583	DNA-binding transcription factor activity
B5U27_RS14505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B5U27_RS14510	COG0417	DNA replication proofreading
B5U27_RS14525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5U27_RS14530	COG0583	DNA-binding transcription factor activity
B5U27_RS14535	COG0840	transmembrane signaling receptor activity
B5U27_RS14555	COG2175	clavaminate synthase activity
B5U27_RS14560	COG1247	-acetyltransferase
B5U27_RS14565	COG0124	histidyl-tRNA synthetase
B5U27_RS14570	COG0583	DNA-binding transcription factor activity
B5U27_RS14575	COG0604	alcohol dehydrogenase
B5U27_RS14610	COG2204	response regulator
B5U27_RS14660	COG1253	flavin adenine dinucleotide binding
B5U27_RS14685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5U27_RS14695	COG1414	Transcriptional regulator
B5U27_RS14700	COG3842	ATPase activity
B5U27_RS14705	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5U27_RS14710	COG1177	transmembrane transport
B5U27_RS14725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS14740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5U27_RS14765	COG0028	Belongs to the TPP enzyme family
B5U27_RS14770	COG0768	penicillin binding
B5U27_RS14775	COG1733	regulation of RNA biosynthetic process
B5U27_RS14780	COG0702	epimerase
B5U27_RS14805	COG2271	Major facilitator Superfamily
B5U27_RS14815	COG2271	Major facilitator Superfamily
B5U27_RS14825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5U27_RS14840	COG3604	Transcriptional regulator
B5U27_RS14845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5U27_RS14845	COG0546	phosphoglycolate phosphatase activity
B5U27_RS14860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B5U27_RS14860	COG0392	lysyltransferase activity
B5U27_RS14870	COG3387	PFAM Glycoside hydrolase 15-related
B5U27_RS14880	COG0667	Aldo Keto reductase
B5U27_RS14895	COG2066	Belongs to the glutaminase family
B5U27_RS14900	COG0235	Class ii aldolase
B5U27_RS14940	COG1999	signal sequence binding
B5U27_RS14945	COG4206	TonB-dependent receptor
B5U27_RS14955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS14965	COG3706	GGDEF domain
B5U27_RS14980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS14985	COG0004	ammonium transporteR
B5U27_RS14995	COG0069	glutamate synthase activity
B5U27_RS15000	COG2218	PFAM glutamate synthase alpha subunit domain protein
B5U27_RS15005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5U27_RS15030	COG1469	GTP cyclohydrolase I activity
B5U27_RS15045	COG0601	transmembrane transport
B5U27_RS15050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5U27_RS15060	COG4608	Belongs to the ABC transporter superfamily
B5U27_RS15075	COG0154	amidase activity
B5U27_RS15085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B5U27_RS15090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B5U27_RS15095	COG3454	Phosphonate metabolism
B5U27_RS15100	COG4778	phosphonate C-P lyase system protein PhnL
B5U27_RS15105	COG4107	phosphonate C-P lyase system protein PhnK
B5U27_RS15110	COG3627	carbon phosphorus lyase activity
B5U27_RS15115	COG3626	phosphonate metabolism
B5U27_RS15125	COG3624	Phosphonate C-P lyase system protein PhnG
B5U27_RS15130	COG2188	Transcriptional regulator
B5U27_RS15135	COG3639	organic phosphonate transmembrane transporter activity
B5U27_RS15140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B5U27_RS15145	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B5U27_RS15160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5U27_RS15165	COG0251	oxidation-reduction process
B5U27_RS15175	COG0840	transmembrane signaling receptor activity
B5U27_RS15275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5U27_RS15290	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5U27_RS15290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5U27_RS15340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS15350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS15400	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B5U27_RS15405	COG0830	nickel cation binding
B5U27_RS15410	COG0832	Belongs to the urease beta subunit family
B5U27_RS15410	COG0831	urea catabolic process
B5U27_RS15415	COG0804	urea catabolic process
B5U27_RS15420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B5U27_RS15425	COG0829	nickel cation binding
B5U27_RS15430	COG1902	pentaerythritol trinitrate reductase activity
B5U27_RS15435	COG0640	Transcriptional regulator
B5U27_RS15470	COG1309	transcriptional regulator
B5U27_RS15475	COG1132	(ABC) transporter
B5U27_RS15490	COG0583	DNA-binding transcription factor activity
B5U27_RS15495	COG0583	DNA-binding transcription factor activity
B5U27_RS15520	COG0583	DNA-binding transcription factor activity
B5U27_RS15540	COG0601	transmembrane transport
B5U27_RS15545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5U27_RS15560	COG0765	amino acid transport
B5U27_RS15565	COG0765	amino acid transport
B5U27_RS15570	COG1126	abc transporter atp-binding protein
B5U27_RS15620	COG3634	alkyl hydroperoxide reductase activity
B5U27_RS15640	COG0784	Response regulator, receiver
B5U27_RS15640	COG4191	Histidine kinase
B5U27_RS15680	COG3387	PFAM Glycoside hydrolase 15-related
B5U27_RS15685	COG0561	phosphatase activity
B5U27_RS15690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5U27_RS15695	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B5U27_RS15710	COG0297	glycogen (starch) synthase activity
B5U27_RS15715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B5U27_RS15720	COG1640	4-alpha-glucanotransferase
B5U27_RS15765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B5U27_RS15770	COG0583	DNA-binding transcription factor activity
B5U27_RS15775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5U27_RS15790	COG1968	undecaprenyl-diphosphatase activity
B5U27_RS15805	COG2204	response regulator
B5U27_RS15860	COG1522	sequence-specific DNA binding
B5U27_RS15870	COG2866	Carboxypeptidase
B5U27_RS15890	COG0217	transcriptional regulatory protein
B5U27_RS15900	COG1024	Enoyl-CoA hydratase
B5U27_RS15905	COG0183	Belongs to the thiolase family
B5U27_RS15970	COG2995	paraquat-inducible protein a
B5U27_RS15975	COG2995	paraquat-inducible protein a
B5U27_RS15980	COG3008	intermembrane lipid transfer
B5U27_RS15995	COG0583	DNA-binding transcription factor activity
B5U27_RS16000	COG1741	Belongs to the pirin family
B5U27_RS16030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5U27_RS16035	COG1349	DNA-binding transcription factor activity
B5U27_RS16125	COG0583	DNA-binding transcription factor activity
B5U27_RS16140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS16155	COG2070	2-Nitropropane dioxygenase
B5U27_RS16165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B5U27_RS16170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5U27_RS16170	COG0473	3-isopropylmalate dehydrogenase activity
B5U27_RS16175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5U27_RS16175	COG0473	3-isopropylmalate dehydrogenase activity
B5U27_RS16180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5U27_RS16230	COG3210	domain, Protein
B5U27_RS16260	COG1538	Outer membrane efflux protein
B5U27_RS16265	COG0745	RESPONSE REGULATOR receiver
B5U27_RS16270	COG2205	protein histidine kinase activity
B5U27_RS16275	COG0659	secondary active sulfate transmembrane transporter activity
B5U27_RS16280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5U27_RS16330	COG5002	protein histidine kinase activity
B5U27_RS16330	COG3447	MASE1 domain protein
B5U27_RS16330	COG5001	Diguanylate cyclase
B5U27_RS16350	COG0406	alpha-ribazole phosphatase activity
B5U27_RS16355	COG4948	Mandelate Racemase Muconate Lactonizing
B5U27_RS16360	COG0747	negative chemotaxis
B5U27_RS16365	COG0601	transmembrane transport
B5U27_RS16370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5U27_RS16375	COG0444	Belongs to the ABC transporter superfamily
B5U27_RS16380	COG4608	Belongs to the ABC transporter superfamily
B5U27_RS16390	COG2186	Transcriptional regulator
B5U27_RS16395	COG2186	Transcriptional regulator
B5U27_RS16405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5U27_RS16410	COG1120	ATPase activity
B5U27_RS16415	COG0826	peptidase U32
B5U27_RS16425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5U27_RS16425	COG2146	nitrite reductase [NAD(P)H] activity
B5U27_RS16430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5U27_RS16430	COG2146	nitrite reductase [NAD(P)H] activity
B5U27_RS16435	COG0596	Alpha beta hydrolase
B5U27_RS16445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5U27_RS16450	COG0581	inorganic phosphate transmembrane transporter activity
B5U27_RS16455	COG0573	inorganic phosphate transmembrane transporter activity
B5U27_RS16460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5U27_RS16485	COG0583	DNA-binding transcription factor activity
B5U27_RS16490	COG3180	Ammonia monooxygenase
B5U27_RS16495	COG2942	2-epimerase
B5U27_RS16505	COG1929	Belongs to the glycerate kinase type-1 family
B5U27_RS16510	COG3835	regulator
B5U27_RS16540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5U27_RS16610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5U27_RS16630	COG0776	regulation of translation
B5U27_RS16635	COG0072	phenylalanine-tRNA ligase activity
B5U27_RS16640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5U27_RS16645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B5U27_RS16650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B5U27_RS16655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B5U27_RS16660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5U27_RS16670	COG1278	Cold shock
B5U27_RS16690	COG1869	D-ribose catabolic process
B5U27_RS16695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5U27_RS16700	COG1609	Transcriptional regulator
B5U27_RS16705	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS16710	COG1129	ABC transporter
B5U27_RS16740	COG0024	Methionine aminopeptidase
B5U27_RS16790	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5U27_RS16795	COG0746	molybdenum cofactor guanylyltransferase activity
B5U27_RS16810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5U27_RS16815	COG1309	transcriptional regulator
B5U27_RS16820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B5U27_RS16820	COG1082	Xylose isomerase domain protein TIM barrel
B5U27_RS16825	COG2271	Major facilitator Superfamily
B5U27_RS16845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B5U27_RS16860	COG3485	protocatechuate 3,4-dioxygenase
B5U27_RS16865	COG3485	protocatechuate 3,4-dioxygenase
B5U27_RS16870	COG0583	DNA-binding transcription factor activity
B5U27_RS16880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B5U27_RS16905	COG2198	Histidine kinase
B5U27_RS16905	COG0784	Response regulator, receiver
B5U27_RS16905	COG2205	protein histidine kinase activity
B5U27_RS16910	COG2197	response regulator
B5U27_RS16915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS16915	COG2205	protein histidine kinase activity
B5U27_RS16920	COG3171	Protein conserved in bacteria
B5U27_RS16935	COG0116	Belongs to the methyltransferase superfamily
B5U27_RS16935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5U27_RS16940	COG3130	regulation of translation
B5U27_RS16945	COG0167	dihydroorotate dehydrogenase activity
B5U27_RS16955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS16955	COG1116	anion transmembrane transporter activity
B5U27_RS16960	COG3707	response regulator
B5U27_RS16970	COG2223	nitrite transmembrane transporter activity
B5U27_RS16975	COG2815	serine threonine protein kinase
B5U27_RS16975	COG0515	serine threonine protein kinase
B5U27_RS16980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5U27_RS16985	COG0243	molybdopterin cofactor binding
B5U27_RS16990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5U27_RS17005	COG0668	transmembrane transport
B5U27_RS17020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5U27_RS17035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B5U27_RS17040	COG2828	Protein conserved in bacteria
B5U27_RS17055	COG0372	Belongs to the citrate synthase family
B5U27_RS17065	COG1802	Transcriptional regulator
B5U27_RS17070	COG0189	ligase activity
B5U27_RS17070	COG4067	protein conserved in archaea
B5U27_RS17085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5U27_RS17090	COG0560	Phosphoserine phosphatase
B5U27_RS17115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5U27_RS17140	COG1376	ErfK ybiS ycfS ynhG family protein
B5U27_RS17155	COG4181	ATPase activity
B5U27_RS17160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B5U27_RS17165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5U27_RS17180	COG2259	Doxx family
B5U27_RS17190	COG0084	hydrolase, TatD family'
B5U27_RS17225	COG0714	Associated with various cellular activities
B5U27_RS17235	COG0745	RESPONSE REGULATOR receiver
B5U27_RS17240	COG2205	protein histidine kinase activity
B5U27_RS17245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B5U27_RS17255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B5U27_RS17300	COG3121	Chaperone
B5U27_RS17305	COG3188	usher protein
B5U27_RS17335	COG2205	protein histidine kinase activity
B5U27_RS17345	COG0628	permease
B5U27_RS17370	COG2062	phosphohistidine phosphatase, SixA
B5U27_RS17380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5U27_RS17385	COG5002	protein histidine kinase activity
B5U27_RS17385	COG0784	Response regulator, receiver
B5U27_RS17385	COG2205	protein histidine kinase activity
B5U27_RS17390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5U27_RS17405	COG0326	Molecular chaperone. Has ATPase activity
B5U27_RS17425	COG0045	succinate-CoA ligase (ADP-forming) activity
B5U27_RS17430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5U27_RS17445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5U27_RS17450	COG1053	succinate dehydrogenase
B5U27_RS17455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B5U27_RS17460	COG2009	succinate dehydrogenase
B5U27_RS17485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5U27_RS17490	COG2885	chlorophyll binding
B5U27_RS17490	COG3047	cAMP biosynthetic process
B5U27_RS17520	COG2207	Transcriptional regulator
B5U27_RS17525	COG1064	alcohol dehydrogenase
B5U27_RS17530	COG1414	Transcriptional regulator
B5U27_RS17535	COG2271	Major facilitator Superfamily
B5U27_RS17540	COG4948	Mandelate Racemase Muconate Lactonizing
B5U27_RS17545	COG0800	Aldolase
B5U27_RS17550	COG3734	2-keto-3-deoxy-galactonokinase
B5U27_RS17560	COG0473	3-isopropylmalate dehydrogenase activity
B5U27_RS17565	COG0066	3-isopropylmalate dehydratase activity
B5U27_RS17570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5U27_RS17590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5U27_RS17620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5U27_RS17630	COG0556	nucleotide-excision repair
B5U27_RS17645	COG2366	antibiotic biosynthetic process
B5U27_RS17650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS17655	COG1136	(ABC) transporter
B5U27_RS17655	COG0577	efflux transmembrane transporter activity
B5U27_RS17760	COG1121	(ABC) transporter
B5U27_RS17765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5U27_RS17815	COG2205	protein histidine kinase activity
B5U27_RS17850	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B5U27_RS17855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5U27_RS17885	COG1247	-acetyltransferase
B5U27_RS17890	COG5002	protein histidine kinase activity
B5U27_RS17915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B5U27_RS17935	COG2853	Lipoprotein
B5U27_RS17940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5U27_RS17950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B5U27_RS17950	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B5U27_RS17955	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5U27_RS17960	COG1136	(ABC) transporter
B5U27_RS17965	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5U27_RS17975	COG0584	glycerophosphoryl diester phosphodiesterase
B5U27_RS17980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5U27_RS17985	COG1477	protein flavinylation
B5U27_RS18005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B5U27_RS18015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5U27_RS18020	COG1335	isochorismatase
B5U27_RS18025	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS18060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5U27_RS18065	COG1349	DNA-binding transcription factor activity
B5U27_RS18075	COG0738	Major facilitator superfamily
B5U27_RS18080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5U27_RS18180	COG0519	Catalyzes the synthesis of GMP from XMP
B5U27_RS18180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5U27_RS18190	COG1305	Transglutaminase-like
B5U27_RS18200	COG2308	Evidence 4 Homologs of previously reported genes of
B5U27_RS18215	COG1368	sulfuric ester hydrolase activity
B5U27_RS18220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B5U27_RS18260	COG2197	response regulator
B5U27_RS18265	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B5U27_RS18270	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B5U27_RS18275	COG0235	Class ii aldolase
B5U27_RS18285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5U27_RS18315	COG2840	Smr protein MutS2
B5U27_RS18325	COG0302	gtp cyclohydrolase
B5U27_RS18340	COG0625	glutathione transferase activity
B5U27_RS18345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5U27_RS18355	COG3135	benzoate transporter
B5U27_RS18360	COG1619	proteins homologs of microcin C7 resistance protein MccF
B5U27_RS18370	COG0284	orotidine-5'-phosphate decarboxylase activity
B5U27_RS18395	COG3123	guanosine phosphorylase activity
B5U27_RS18400	COG1132	(ABC) transporter
B5U27_RS18410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5U27_RS18415	COG0425	Belongs to the sulfur carrier protein TusA family
B5U27_RS18420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B5U27_RS18425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B5U27_RS18440	COG0668	transmembrane transport
B5U27_RS18495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5U27_RS18500	COG3115	cell septum assembly
B5U27_RS18530	COG0402	S-adenosylhomocysteine deaminase activity
B5U27_RS18555	COG4266	Belongs to the allantoicase family
B5U27_RS18560	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B5U27_RS18575	COG2354	Protein conserved in bacteria
B5U27_RS18580	COG1522	sequence-specific DNA binding
B5U27_RS18585	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B5U27_RS18600	COG0583	DNA-binding transcription factor activity
B5U27_RS18610	COG0840	transmembrane signaling receptor activity
B5U27_RS18625	COG2175	clavaminate synthase activity
B5U27_RS18630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B5U27_RS18655	COG0667	Aldo Keto reductase
B5U27_RS18685	COG3046	protein related to deoxyribodipyrimidine photolyase
B5U27_RS18690	COG0625	glutathione transferase activity
B5U27_RS18725	COG1472	Belongs to the glycosyl hydrolase 3 family
B5U27_RS18740	COG1309	transcriptional regulator
B5U27_RS18745	COG0840	transmembrane signaling receptor activity
B5U27_RS18750	COG0656	L-ascorbic acid biosynthetic process
B5U27_RS18760	COG0306	phosphate transporter
B5U27_RS18780	COG1024	Enoyl-CoA hydratase
B5U27_RS18785	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS18795	COG0431	NADPH-dependent FMN reductase
B5U27_RS18810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5U27_RS18815	COG1045	serine acetyltransferase
B5U27_RS18825	COG0328	RNA-DNA hybrid ribonuclease activity
B5U27_RS18835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5U27_RS18840	COG1388	LysM domain
B5U27_RS18840	COG0741	lytic transglycosylase activity
B5U27_RS18845	COG4166	transmembrane transport
B5U27_RS18850	COG4166	transmembrane transport
B5U27_RS18855	COG4174	ABC transporter (Permease)
B5U27_RS18860	COG4239	(ABC) transporter, permease
B5U27_RS18865	COG4172	Belongs to the ABC transporter superfamily
B5U27_RS18875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5U27_RS18880	COG0776	regulation of translation
B5U27_RS18885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5U27_RS18890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5U27_RS18895	COG0740	serine-type endopeptidase activity
B5U27_RS18900	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5U27_RS18920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5U27_RS18935	COG0395	ABC-type sugar transport system, permease component
B5U27_RS18945	COG3842	ATPase activity
B5U27_RS18950	COG3842	ATPase activity
B5U27_RS18955	COG3284	Transcriptional regulator
B5U27_RS18960	COG0215	cysteine-tRNA ligase activity
B5U27_RS18965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5U27_RS18975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5U27_RS18990	COG1902	pentaerythritol trinitrate reductase activity
B5U27_RS18990	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5U27_RS19010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5U27_RS19050	COG1286	toxin biosynthetic process
B5U27_RS19060	COG0285	dihydrofolate synthase activity
B5U27_RS19065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B5U27_RS19070	COG0135	phosphoribosylanthranilate isomerase activity
B5U27_RS19115	COG0084	hydrolase, TatD family'
B5U27_RS19130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5U27_RS19135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B5U27_RS19145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5U27_RS19150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5U27_RS19165	COG0416	fatty acid biosynthetic process
B5U27_RS19170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5U27_RS19180	COG0424	maF-like protein
B5U27_RS19185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5U27_RS19185	COG0616	signal peptide processing
B5U27_RS19205	COG1530	ribonuclease E activity
B5U27_RS19210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5U27_RS19215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B5U27_RS19220	COG2835	tetraacyldisaccharide 4'-kinase activity
B5U27_RS19225	COG1663	tetraacyldisaccharide 4'-kinase activity
B5U27_RS19230	COG0848	biopolymer transport protein
B5U27_RS19235	COG0811	peptide transport
B5U27_RS19245	COG0842	Transport permease protein
B5U27_RS19250	COG1131	(ABC) transporter
B5U27_RS19255	COG0625	glutathione transferase activity
B5U27_RS19275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5U27_RS19315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5U27_RS19335	COG1560	Kdo2-lipid A biosynthetic process
B5U27_RS19340	COG0850	regulation of cytokinetic process
B5U27_RS19345	COG2894	cell division
B5U27_RS19350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B5U27_RS19355	COG0564	pseudouridine synthase activity
B5U27_RS19365	COG1362	aminopeptidase activity
B5U27_RS19410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B5U27_RS19410	COG0604	alcohol dehydrogenase
B5U27_RS19410	COG3321	synthase
B5U27_RS19410	COG4221	oxidoreductase activity
B5U27_RS19420	COG2200	EAL domain
B5U27_RS19465	COG1301	dicarboxylic acid transport
B5U27_RS19475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5U27_RS19505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5U27_RS19510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5U27_RS19520	COG1414	Transcriptional regulator
B5U27_RS19535	COG2974	May be involved in recombination
B5U27_RS19540	COG0385	Bile acid
B5U27_RS19585	COG4251	negative regulation of phosphorylation
B5U27_RS19625	COG0642	Histidine kinase
B5U27_RS19630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS19635	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS19640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5U27_RS19645	COG5383	Protein conserved in bacteria
B5U27_RS19655	COG0583	DNA-binding transcription factor activity
B5U27_RS19660	COG1760	l-serine dehydratase
B5U27_RS19675	COG0583	DNA-binding transcription factor activity
B5U27_RS19680	COG1473	amidohydrolase
B5U27_RS19685	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS19695	COG0583	DNA-binding transcription factor activity
B5U27_RS19700	COG1063	alcohol dehydrogenase
B5U27_RS19715	COG1953	Uracil, thiamine, allantoin
B5U27_RS19720	COG0784	Response regulator, receiver
B5U27_RS19720	COG4191	Histidine kinase
B5U27_RS19750	COG0556	nucleotide-excision repair
B5U27_RS19780	COG2239	Acts as a magnesium transporter
B5U27_RS19805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B5U27_RS19810	COG0527	aspartate kinase activity
B5U27_RS19815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5U27_RS19820	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B5U27_RS19825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5U27_RS19830	COG2988	succinylglutamate desuccinylase activity
B5U27_RS19840	COG3724	N-succinylarginine dihydrolase activity
B5U27_RS19845	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS19860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5U27_RS19895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS19900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5U27_RS19925	COG2154	pterin-4-alpha-carbinolamine dehydratase
B5U27_RS19965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5U27_RS19975	COG0009	L-threonylcarbamoyladenylate synthase
B5U27_RS19985	COG2917	probably involved in intracellular septation
B5U27_RS19990	COG2350	Protein conserved in bacteria
B5U27_RS20000	COG0745	RESPONSE REGULATOR receiver
B5U27_RS20015	COG0642	Histidine kinase
B5U27_RS20025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5U27_RS20030	COG2814	Major facilitator Superfamily
B5U27_RS20035	COG1566	PFAM secretion protein HlyD family protein
B5U27_RS20040	COG1846	Transcriptional regulator
B5U27_RS20060	COG1971	Probably functions as a manganese efflux pump
B5U27_RS20105	COG0714	Associated with various cellular activities
B5U27_RS20120	COG2304	oxidoreductase activity
B5U27_RS20135	COG0420	3'-5' exonuclease activity
B5U27_RS20155	COG2706	6-phosphogluconolactonase activity
B5U27_RS20180	COG1609	Transcriptional regulator
B5U27_RS20230	COG0754	glutathionylspermidine amidase activity
B5U27_RS20240	COG3766	membrane
B5U27_RS20265	COG0308	aminopeptidase N
B5U27_RS20275	COG3139	Protein of unknown function (DUF1315)
B5U27_RS20285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5U27_RS20290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5U27_RS20310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B5U27_RS20315	COG2223	nitrite transmembrane transporter activity
B5U27_RS20335	COG1116	anion transmembrane transporter activity
B5U27_RS20340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5U27_RS20350	COG0583	DNA-binding transcription factor activity
B5U27_RS20365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS20370	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS20380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS20385	COG0583	DNA-binding transcription factor activity
B5U27_RS20390	COG1741	Belongs to the pirin family
B5U27_RS20425	COG1956	GAF domain-containing protein
B5U27_RS20435	COG0784	Response regulator, receiver
B5U27_RS20435	COG5002	protein histidine kinase activity
B5U27_RS20435	COG2205	protein histidine kinase activity
B5U27_RS20440	COG0386	Belongs to the glutathione peroxidase family
B5U27_RS20445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5U27_RS20450	COG0436	Aminotransferase
B5U27_RS20455	COG0501	Belongs to the peptidase M48B family
B5U27_RS20465	COG3384	dioxygenase
B5U27_RS20485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B5U27_RS20520	COG0583	DNA-binding transcription factor activity
B5U27_RS20530	COG1846	Transcriptional regulator
B5U27_RS20535	COG1764	response to oxidative stress
B5U27_RS20545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5U27_RS20570	COG0814	amino acid
B5U27_RS20580	COG1555	photosystem II stabilization
B5U27_RS20590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5U27_RS20600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5U27_RS20610	COG0776	regulation of translation
B5U27_RS20620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5U27_RS20625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5U27_RS20635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B5U27_RS20645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B5U27_RS20650	COG0402	S-adenosylhomocysteine deaminase activity
B5U27_RS20655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5U27_RS20660	COG0546	phosphoglycolate phosphatase activity
B5U27_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS20680	COG5001	Diguanylate cyclase
B5U27_RS20680	COG5002	protein histidine kinase activity
B5U27_RS20695	COG1054	Belongs to the UPF0176 family
B5U27_RS20700	COG0271	Belongs to the BolA IbaG family
B5U27_RS20710	COG0114	fumarate hydratase activity
B5U27_RS20720	COG0697	spore germination
B5U27_RS20775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5U27_RS20780	COG0406	alpha-ribazole phosphatase activity
B5U27_RS20785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B5U27_RS20795	COG1492	cobalamin metabolic process
B5U27_RS20805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B5U27_RS20810	COG0778	Nitroreductase
B5U27_RS20815	COG1797	cobyrinic acid a,c-diamide synthase activity
B5U27_RS20830	COG0791	NLP P60 protein
B5U27_RS20835	COG0791	NLP P60 protein
B5U27_RS20835	COG1388	LysM domain
B5U27_RS20840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B5U27_RS20845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B5U27_RS20850	COG0628	permease
B5U27_RS20865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5U27_RS20870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B5U27_RS20890	COG3956	TIGRFAM MazG family protein
B5U27_RS20895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5U27_RS20900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5U27_RS20930	COG3118	belongs to the thioredoxin family
B5U27_RS20935	COG1393	Belongs to the ArsC family
B5U27_RS20945	COG2818	Glycosylase
B5U27_RS20950	COG0037	tRNA processing
B5U27_RS20955	COG3091	SprT-like family
B5U27_RS20960	COG1301	dicarboxylic acid transport
B5U27_RS21000	COG2977	Belongs to the P-Pant transferase superfamily
B5U27_RS21010	COG2205	protein histidine kinase activity
B5U27_RS21015	COG0745	RESPONSE REGULATOR receiver
B5U27_RS21025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5U27_RS21060	COG0840	transmembrane signaling receptor activity
B5U27_RS21075	COG1846	Transcriptional regulator
B5U27_RS21090	COG2832	Protein of unknown function (DUF454)
B5U27_RS21095	COG2326	polyphosphate kinase activity
B5U27_RS21100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5U27_RS21100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5U27_RS21105	COG4181	ATPase activity
B5U27_RS21130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5U27_RS21130	COG0189	ligase activity
B5U27_RS21135	COG1363	Peptidase, m42
B5U27_RS21140	COG3089	Belongs to the UPF0270 family
B5U27_RS21145	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B5U27_RS21150	COG1742	UPF0060 membrane protein
B5U27_RS21170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5U27_RS21175	COG3162	membrane
B5U27_RS21190	COG2853	Lipoprotein
B5U27_RS21200	COG0583	DNA-binding transcription factor activity
B5U27_RS21210	COG3706	GGDEF domain
B5U27_RS21230	COG2197	response regulator
B5U27_RS21260	COG2133	pyrroloquinoline quinone binding
B5U27_RS21275	COG2205	protein histidine kinase activity
B5U27_RS21280	COG0596	Alpha beta hydrolase
B5U27_RS21285	COG0590	tRNA wobble adenosine to inosine editing
B5U27_RS21305	COG0242	peptide deformylase activity
B5U27_RS21310	COG1295	ribonuclease BN
B5U27_RS21330	COG2996	Protein conserved in bacteria
B5U27_RS21365	COG0513	Belongs to the DEAD box helicase family
B5U27_RS21380	COG0745	RESPONSE REGULATOR receiver
B5U27_RS21425	COG0668	transmembrane transport
B5U27_RS21460	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS21465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5U27_RS21470	COG1335	isochorismatase
B5U27_RS21475	COG3845	ABC transporter
B5U27_RS21490	COG1802	Transcriptional regulator
B5U27_RS21520	COG3386	PFAM SMP-30 Gluconolaconase
B5U27_RS21545	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS21545	COG0604	alcohol dehydrogenase
B5U27_RS21545	COG3321	synthase
B5U27_RS21550	COG0640	Transcriptional regulator
B5U27_RS21570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5U27_RS21585	COG0109	protoheme IX farnesyltransferase activity
B5U27_RS21595	COG1845	cytochrome c oxidase, subunit III
B5U27_RS21600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5U27_RS21605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5U27_RS21615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B5U27_RS21620	COG0784	Response regulator, receiver
B5U27_RS21620	COG0835	chemotaxis
B5U27_RS21645	COG3121	Chaperone
B5U27_RS21650	COG3188	usher protein
B5U27_RS21655	COG3121	Chaperone
B5U27_RS21685	COG5002	protein histidine kinase activity
B5U27_RS21690	COG4251	negative regulation of phosphorylation
B5U27_RS21690	COG5001	Diguanylate cyclase
B5U27_RS21690	COG2203	Gaf domain
B5U27_RS21690	COG3706	GGDEF domain
B5U27_RS21700	COG3530	Putative quorum-sensing-regulated virulence factor
B5U27_RS21705	COG0800	Aldolase
B5U27_RS21720	COG1737	Transcriptional regulator
B5U27_RS21755	COG1175	transmembrane transport
B5U27_RS21760	COG1653	transport
B5U27_RS21790	COG1595	DNA-templated transcription, initiation
B5U27_RS21810	COG2832	Protein of unknown function (DUF454)
B5U27_RS21830	COG2205	protein histidine kinase activity
B5U27_RS21835	COG0784	Response regulator, receiver
B5U27_RS21895	COG0509	glycine decarboxylation via glycine cleavage system
B5U27_RS21900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5U27_RS21900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5U27_RS21905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5U27_RS21910	COG1278	Cold shock
B5U27_RS21915	COG0795	lipopolysaccharide-transporting ATPase activity
B5U27_RS21920	COG0795	lipopolysaccharide-transporting ATPase activity
B5U27_RS21925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5U27_RS21960	COG0525	valine-tRNA ligase activity
B5U27_RS21965	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B5U27_RS21980	COG3081	Nucleoid-associated protein
B5U27_RS22000	COG2827	Endonuclease containing a URI domain
B5U27_RS22020	COG2807	transmembrane transport
B5U27_RS22030	COG1126	abc transporter atp-binding protein
B5U27_RS22035	COG0765	amino acid transport
B5U27_RS22040	COG4597	amino acid ABC transporter
B5U27_RS22045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS22055	COG0513	Belongs to the DEAD box helicase family
B5U27_RS22080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B5U27_RS22085	COG0315	cyclic pyranopterin monophosphate synthase activity
B5U27_RS22090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B5U27_RS22100	COG3022	response to hydroperoxide
B5U27_RS22110	COG1215	transferase activity, transferring glycosyl groups
B5U27_RS22115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5U27_RS22120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B5U27_RS22130	COG3420	alginic acid biosynthetic process
B5U27_RS22145	COG1696	Membrane protein involved in D-alanine export
B5U27_RS22160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B5U27_RS22160	COG0662	Cupin 2, conserved barrel domain protein
B5U27_RS22170	COG0300	oxidoreductase activity
B5U27_RS22175	COG1566	PFAM secretion protein HlyD family protein
B5U27_RS22195	COG0583	DNA-binding transcription factor activity
B5U27_RS22205	COG0697	spore germination
B5U27_RS22235	COG3712	iron ion homeostasis
B5U27_RS22245	COG4772	TonB-dependent receptor
B5U27_RS22295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B5U27_RS22305	COG1215	transferase activity, transferring glycosyl groups
B5U27_RS22330	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS22355	COG0302	gtp cyclohydrolase
B5U27_RS22360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5U27_RS22375	COG0492	ferredoxin-NADP+ reductase activity
B5U27_RS22380	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B5U27_RS22415	COG0386	Belongs to the glutathione peroxidase family
B5U27_RS22420	COG1047	Peptidyl-prolyl cis-trans
B5U27_RS22430	COG0280	phosphate acetyltransferase
B5U27_RS22430	COG0857	belongs to the CobB CobQ family
B5U27_RS22435	COG0204	Acyl-transferase
B5U27_RS22440	COG2885	chlorophyll binding
B5U27_RS22445	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5U27_RS22455	COG3845	ABC transporter
B5U27_RS22465	COG1309	transcriptional regulator
B5U27_RS22470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS22475	COG1335	isochorismatase
B5U27_RS22480	COG0251	oxidation-reduction process
B5U27_RS22485	COG0596	Alpha beta hydrolase
B5U27_RS22490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B5U27_RS22515	COG0318	PFAM AMP-dependent synthetase and ligase
B5U27_RS22520	COG1280	lysine exporter protein (LysE YggA)
B5U27_RS22530	COG2813	Specifically methylates the guanine in position
B5U27_RS22535	COG2119	membrane
B5U27_RS22540	COG0501	Belongs to the peptidase M48B family
B5U27_RS22545	COG2135	peptidase activity
B5U27_RS22590	COG0579	oxidoreductase
B5U27_RS22600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS22605	COG0765	amino acid transport
B5U27_RS22620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B5U27_RS22625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5U27_RS22640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B5U27_RS22645	COG1090	epimerase
B5U27_RS22650	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B5U27_RS22665	COG0789	Transcriptional regulator
B5U27_RS22670	COG0415	Belongs to the DNA photolyase family
B5U27_RS22680	COG4221	oxidoreductase activity
B5U27_RS22685	COG0493	'glutamate synthase
B5U27_RS22695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B5U27_RS22720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5U27_RS22725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5U27_RS22735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5U27_RS22740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B5U27_RS22750	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B5U27_RS22755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B5U27_RS22765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B5U27_RS22770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B5U27_RS22775	COG0193	aminoacyl-tRNA hydrolase activity
B5U27_RS22780	COG0012	GTP binding
B5U27_RS22785	COG0582	viral genome integration into host DNA
B5U27_RS22895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS22935	COG2814	Major facilitator Superfamily
B5U27_RS22960	COG0583	DNA-binding transcription factor activity
B5U27_RS23010	COG3642	lipopolysaccharide core region biosynthetic process
B5U27_RS23020	COG0642	Histidine kinase
B5U27_RS23035	COG0459	protein refolding
B5U27_RS23040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5U27_RS23045	COG3030	protein affecting phage T7 exclusion by the F plasmid
B5U27_RS23050	COG1028	Short-chain dehydrogenase reductase Sdr
B5U27_RS23060	COG3695	enzyme binding
B5U27_RS23065	COG2211	Major facilitator Superfamily
B5U27_RS23095	COG0668	transmembrane transport
B5U27_RS23100	COG1666	GTP binding
B5U27_RS23110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS23110	COG4191	Histidine kinase
B5U27_RS23115	COG2096	Adenosyltransferase
B5U27_RS23120	COG0494	nUDIX hydrolase
B5U27_RS23130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B5U27_RS23135	COG0653	protein targeting
B5U27_RS23145	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B5U27_RS23150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5U27_RS23165	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5U27_RS23170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5U27_RS23175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5U27_RS23180	COG0772	Belongs to the SEDS family
B5U27_RS23185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5U27_RS23190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5U27_RS23195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B5U27_RS23200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5U27_RS23215	COG0275	rRNA processing
B5U27_RS23220	COG2001	Belongs to the MraZ family
B5U27_RS23235	COG3107	peptidoglycan biosynthetic process
B5U27_RS23240	COG0792	nuclease activity
B5U27_RS23245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5U27_RS23250	COG2823	Periplasmic or secreted lipoprotein
B5U27_RS23255	COG2969	positive regulation of protein catabolic process
B5U27_RS23260	COG0625	glutathione transferase activity
B5U27_RS23265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B5U27_RS23270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5U27_RS23280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5U27_RS23285	COG0180	Tryptophanyl-tRNA synthetase
B5U27_RS23305	COG0175	sulfate reduction
B5U27_RS23315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5U27_RS23320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5U27_RS23325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5U27_RS23330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5U27_RS23340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5U27_RS23360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B5U27_RS23365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B5U27_RS23370	COG1127	ABC transporter
B5U27_RS23380	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B5U27_RS23390	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B5U27_RS23395	COG1137	ATPase activity
B5U27_RS23400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B5U27_RS23405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5U27_RS23415	COG1660	Displays ATPase and GTPase activities
B5U27_RS23460	COG0312	modulator of DNA gyrase
B5U27_RS23465	COG3028	Belongs to the UPF0307 family
B5U27_RS23470	COG0312	modulator of DNA gyrase
B5U27_RS23475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5U27_RS23485	COG1530	ribonuclease E activity
B5U27_RS23490	COG0424	maF-like protein
B5U27_RS23500	COG1792	Involved in formation and maintenance of cell shape
B5U27_RS23505	COG1077	Cell shape determining protein MreB Mrl
B5U27_RS23510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5U27_RS23515	COG0154	amidase activity
B5U27_RS23520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5U27_RS23525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B5U27_RS23535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B5U27_RS23550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5U27_RS23565	COG2823	Periplasmic or secreted lipoprotein
B5U27_RS23570	COG1185	polyribonucleotide nucleotidyltransferase activity
B5U27_RS23580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B5U27_RS23585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5U27_RS23590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B5U27_RS23595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5U27_RS23600	COG0195	Participates in both transcription termination and antitermination
B5U27_RS23605	COG0779	Required for maturation of 30S ribosomal subunits
B5U27_RS23620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5U27_RS23625	COG0149	triose-phosphate isomerase activity
B5U27_RS23630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5U27_RS23635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5U27_RS23645	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B5U27_RS23655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5U27_RS23660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5U27_RS23665	COG0505	Belongs to the CarA family
B5U27_RS23675	COG0484	heat shock protein binding
B5U27_RS23680	COG0443	Heat shock 70 kDa protein
B5U27_RS23685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5U27_RS23690	COG0497	DNA recombination
B5U27_RS23700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5U27_RS23705	COG2914	Belongs to the UPF0125 (RnfH) family
B5U27_RS23715	COG0733	neurotransmitter:sodium symporter activity
B5U27_RS23720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B5U27_RS23790	COG5001	Diguanylate cyclase
B5U27_RS23800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B5U27_RS23815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5U27_RS23825	COG4608	Belongs to the ABC transporter superfamily
B5U27_RS23830	COG0444	Belongs to the ABC transporter superfamily
B5U27_RS23835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5U27_RS23840	COG0601	transmembrane transport
B5U27_RS23845	COG2197	response regulator
B5U27_RS23850	COG2267	carboxylic ester hydrolase activity
B5U27_RS23870	COG2205	protein histidine kinase activity
B5U27_RS23870	COG2198	Histidine kinase
B5U27_RS23870	COG0784	Response regulator, receiver
B5U27_RS23895	COG5001	Diguanylate cyclase
B5U27_RS23900	COG0730	response to heat
B5U27_RS23920	COG2721	sulfolactate sulfo-lyase activity
B5U27_RS23925	COG2271	Major facilitator Superfamily
B5U27_RS23930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5U27_RS23935	COG2186	Transcriptional regulator
B5U27_RS23940	COG4178	(ABC) transporter
B5U27_RS23950	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B5U27_RS23965	COG0747	negative chemotaxis
B5U27_RS23970	COG0747	negative chemotaxis
B5U27_RS23975	COG0747	negative chemotaxis
B5U27_RS23985	COG0747	negative chemotaxis
B5U27_RS23990	COG0601	transmembrane transport
B5U27_RS23995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5U27_RS24000	COG0444	Belongs to the ABC transporter superfamily
B5U27_RS24005	COG4608	Belongs to the ABC transporter superfamily
B5U27_RS24025	COG0019	diaminopimelate decarboxylase activity
B5U27_RS24060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B5U27_RS24065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5U27_RS24070	COG0545	Peptidyl-prolyl cis-trans isomerase
B5U27_RS24080	COG2862	Uncharacterized protein family, UPF0114
B5U27_RS24090	COG1067	ATP-dependent peptidase activity
B5U27_RS24115	COG0488	(ABC) transporter
B5U27_RS24135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5U27_RS24140	COG0523	cobalamin synthesis protein
B5U27_RS24145	COG2879	small protein
B5U27_RS24150	COG1966	Carbon starvation protein
B5U27_RS24165	COG1970	mechanosensitive ion channel activity
B5U27_RS24185	COG2197	response regulator
B5U27_RS24200	COG1294	oxidase, subunit
B5U27_RS24205	COG1271	oxidase subunit
B5U27_RS24210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5U27_RS24215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B5U27_RS24220	COG2080	2 iron, 2 sulfur cluster binding
B5U27_RS24225	COG2252	PERMEase
B5U27_RS24230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5U27_RS24240	COG2321	neutral zinc metallopeptidase
B5U27_RS24255	COG1946	Acyl-CoA thioesterase
B5U27_RS24265	COG0123	including yeast histone deacetylase and acetoin utilization protein
B5U27_RS24275	COG0513	Belongs to the DEAD box helicase family
B5U27_RS24280	COG0697	spore germination
B5U27_RS24285	COG1522	sequence-specific DNA binding
B5U27_RS24290	COG1199	ATP-dependent helicase activity
B5U27_RS24290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5U27_RS24305	COG3416	Protein conserved in bacteria
B5U27_RS24335	COG1643	Atp-dependent helicase
B5U27_RS24340	COG0484	heat shock protein binding
B5U27_RS24350	COG2384	SAM-dependent methyltransferase
B5U27_RS24385	COG1522	sequence-specific DNA binding
B5U27_RS24395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B5U27_RS24400	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS24415	COG0351	phosphomethylpyrimidine kinase
B5U27_RS24420	COG0352	thiamine-phosphate diphosphorylase activity
B5U27_RS24425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5U27_RS24440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5U27_RS24445	COG1702	phosphate starvation-inducible protein PhoH
B5U27_RS24450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5U27_RS24455	COG4535	Mg2 and Co2 transporter CorC
B5U27_RS24460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5U27_RS24465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B5U27_RS24475	COG0495	leucyl-tRNA aminoacylation
B5U27_RS24500	COG2951	lytic endotransglycosylase activity
B5U27_RS24505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B5U27_RS24510	COG0321	lipoyl(octanoyl) transferase activity
B5U27_RS24515	COG2921	Belongs to the UPF0250 family
B5U27_RS24520	COG1686	Belongs to the peptidase S11 family
B5U27_RS24530	COG2951	lytic endotransglycosylase activity
B5U27_RS24535	COG0772	Belongs to the SEDS family
B5U27_RS24540	COG0768	penicillin binding
B5U27_RS24545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B5U27_RS24555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5U27_RS24560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5U27_RS24565	COG2094	Belongs to the DNA glycosylase MPG family
B5U27_RS24570	COG0586	Pfam SNARE associated Golgi protein
B5U27_RS24615	COG0023	Translation Initiation Factor
B5U27_RS24620	COG1166	arginine decarboxylase activity
B5U27_RS24635	COG0534	Mate efflux family protein
B5U27_RS24650	COG4953	penicillin-binding protein 1C
B5U27_RS24675	COG4964	Belongs to the GSP D family
B5U27_RS24715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5U27_RS24730	COG2264	protein methyltransferase activity
B5U27_RS24740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5U27_RS24750	COG0138	bifunctional purine biosynthesis protein purh
B5U27_RS24755	COG0151	Belongs to the GarS family
B5U27_RS24765	COG2095	MarC family integral membrane protein
B5U27_RS24805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5U27_RS24815	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B5U27_RS24825	COG3657	addiction module killer protein
B5U27_RS24830	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5U27_RS24855	COG0683	leucine binding
B5U27_RS24880	COG0829	nickel cation binding
B5U27_RS24885	COG0831	urea catabolic process
B5U27_RS24900	COG0832	Belongs to the urease beta subunit family
B5U27_RS24905	COG0804	urea catabolic process
B5U27_RS24920	COG0484	heat shock protein binding
B5U27_RS24925	COG0443	Heat shock 70 kDa protein
B5U27_RS24945	COG0697	spore germination
B5U27_RS24995	COG2982	Protein involved in outer membrane biogenesis
B5U27_RS25005	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B5U27_RS25010	COG0830	nickel cation binding
B5U27_RS25015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B5U27_RS25030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5U27_RS25040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5U27_RS25045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5U27_RS25060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5U27_RS25060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5U27_RS25065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5U27_RS25075	COG2264	protein methyltransferase activity
B5U27_RS25080	COG3118	belongs to the thioredoxin family
B5U27_RS25115	COG3047	cAMP biosynthetic process
B5U27_RS25130	COG0668	transmembrane transport
B5U27_RS25140	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5U27_RS25170	COG1653	transport
B5U27_RS25175	COG1175	transmembrane transport
B5U27_RS25185	COG3842	ATPase activity
B5U27_RS25190	COG0584	glycerophosphoryl diester phosphodiesterase
B5U27_RS25195	COG0483	inositol monophosphate 1-phosphatase activity
B5U27_RS25215	COG0629	single-stranded DNA binding
B5U27_RS25220	COG2814	Major facilitator Superfamily
B5U27_RS25225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5U27_RS25230	COG2193	ferroxidase activity
B5U27_RS25240	COG0203	ribosomal protein L17
B5U27_RS25245	COG0202	RNA polymerase activity
B5U27_RS25250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5U27_RS25255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5U27_RS25260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5U27_RS25265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5U27_RS25275	COG0200	Binds to the 23S rRNA
B5U27_RS25280	COG1841	ribosomal large subunit assembly
B5U27_RS25285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5U27_RS25290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B5U27_RS25295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5U27_RS25300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5U27_RS25305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5U27_RS25310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5U27_RS25315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5U27_RS25320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5U27_RS25325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5U27_RS25330	COG0255	Belongs to the universal ribosomal protein uL29 family
B5U27_RS25335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B5U27_RS25340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5U27_RS25345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5U27_RS25350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5U27_RS25355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5U27_RS25360	COG0089	rRNA binding
B5U27_RS25365	COG0088	Forms part of the polypeptide exit tunnel
B5U27_RS25370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5U27_RS25375	COG0051	transcription antitermination factor activity, RNA binding
B5U27_RS25380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5U27_RS25385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5U27_RS25390	COG0049	tRNA binding
B5U27_RS25395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B5U27_RS25400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5U27_RS25405	COG0085	RNA polymerase activity
B5U27_RS25410	COG0222	ribosome binding
B5U27_RS25415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5U27_RS25420	COG0081	regulation of translation
B5U27_RS25425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B5U27_RS25465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B5U27_RS25470	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B5U27_RS25470	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B5U27_RS25505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5U27_RS25510	COG0739	heme binding
B5U27_RS25515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B5U27_RS25520	COG0316	Belongs to the HesB IscA family
B5U27_RS25525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B5U27_RS25530	COG1981	membrane
B5U27_RS25545	COG0537	adenosine 5'-monophosphoramidase activity
B5U27_RS25550	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B5U27_RS25555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B5U27_RS25560	COG1765	OsmC-like protein
B5U27_RS25570	COG0095	Lipoate-protein ligase
B5U27_RS25575	COG0134	indole-3-glycerol-phosphate synthase activity
B5U27_RS25580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5U27_RS25585	COG0512	Glutamine amidotransferase of anthranilate synthase
B5U27_RS25590	COG0546	phosphoglycolate phosphatase activity
B5U27_RS25600	COG3179	chitinase
B5U27_RS25625	COG3299	homolog of phage Mu protein gp47
B5U27_RS25665	COG4386	tail sheath protein
B5U27_RS25740	COG0546	phosphoglycolate phosphatase activity
B5U27_RS25745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5U27_RS25755	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5U27_RS25765	COG3842	ATPase activity
B5U27_RS25775	COG2197	response regulator
B5U27_RS25780	COG4585	Histidine kinase
B5U27_RS25790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B5U27_RS25795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B5U27_RS25800	COG3178	'Phosphotransferase
B5U27_RS25805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B5U27_RS25810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5U27_RS25815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5U27_RS25820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B5U27_RS25825	COG2967	ApaG domain
B5U27_RS25830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5U27_RS25835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5U27_RS25840	COG2766	serine protein kinase
B5U27_RS25845	COG2718	Belongs to the UPF0229 family
B5U27_RS25850	COG2719	SpoVR family
B5U27_RS25855	COG0617	tRNA 3'-terminal CCA addition
B5U27_RS25860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5U27_RS25865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5U27_RS25870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B5U27_RS25875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5U27_RS25880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B5U27_RS25885	COG0358	DNA primase activity
B5U27_RS25890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5U27_RS25915	COG3266	domain, Protein
B5U27_RS25915	COG0515	serine threonine protein kinase
B5U27_RS25945	COG2116	formate transmembrane transporter activity
B5U27_RS26010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5U27_RS26015	COG1025	Belongs to the peptidase M16 family
B5U27_RS26025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B5U27_RS26030	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B5U27_RS26040	COG0535	radical SAM domain protein
B5U27_RS26055	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS26060	COG3706	GGDEF domain
B5U27_RS26070	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS26090	COG2226	methyltransferase
B5U27_RS26090	COG1073	alpha beta
B5U27_RS26095	COG0156	8-amino-7-oxononanoate synthase activity
B5U27_RS26100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5U27_RS26105	COG1040	competence protein
B5U27_RS26110	COG3585	molybdate ion transport
B5U27_RS26110	COG2005	Transcriptional regulator
B5U27_RS26125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B5U27_RS26130	COG3842	ATPase activity
B5U27_RS26135	COG1177	transmembrane transport
B5U27_RS26140	COG1175	transmembrane transport
B5U27_RS26155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B5U27_RS26170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5U27_RS26195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5U27_RS26235	COG4175	Glycine betaine
B5U27_RS26240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5U27_RS26270	COG1063	alcohol dehydrogenase
B5U27_RS26295	COG0204	Acyl-transferase
B5U27_RS26310	COG0625	glutathione transferase activity
B5U27_RS26325	COG3712	iron ion homeostasis
B5U27_RS26330	COG1595	DNA-templated transcription, initiation
B5U27_RS26335	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B5U27_RS26345	COG1012	belongs to the aldehyde dehydrogenase family
B5U27_RS26350	COG1309	transcriptional regulator
B5U27_RS26355	COG1160	GTP binding
B5U27_RS26375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5U27_RS26380	COG2022	thiamine diphosphate biosynthetic process
B5U27_RS26390	COG2363	Small membrane protein
B5U27_RS26395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5U27_RS26405	COG2177	Part of the ABC transporter FtsEX involved in
B5U27_RS26410	COG2884	Cell division ATP-binding protein ftsE
B5U27_RS26415	COG0552	protein localization to endoplasmic reticulum
B5U27_RS26420	COG0612	Peptidase, M16
B5U27_RS26425	COG0612	Peptidase, M16
B5U27_RS26430	COG0742	ribosomal rna small subunit methyltransferase
B5U27_RS26440	COG0429	hydrolase of the alpha beta-hydrolase fold
B5U27_RS26450	COG1309	transcriptional regulator
B5U27_RS26455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5U27_RS26460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5U27_RS26470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5U27_RS26475	COG1639	'signal transduction protein
B5U27_RS26480	COG0693	protein deglycase activity
B5U27_RS26485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5U27_RS26510	COG0477	Major facilitator Superfamily
B5U27_RS26520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5U27_RS26525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B5U27_RS26555	COG4638	Rieske (2fe-2S)
B5U27_RS26560	COG3469	chitinase activity
B5U27_RS26570	COG3469	chitinase activity
B5U27_RS26585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B5U27_RS26590	COG2181	nitrate reductase activity
B5U27_RS26590	COG0247	lactate metabolic process
B5U27_RS26595	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5U27_RS26595	COG1902	pentaerythritol trinitrate reductase activity
B5U27_RS26645	COG0126	phosphoglycerate kinase activity
B5U27_RS26655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5U27_RS26665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5U27_RS26685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5U27_RS26690	COG1422	Protein of unknown function (DUF1090)
B5U27_RS26700	COG0642	Histidine kinase
B5U27_RS26735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS26765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5U27_RS26785	COG0484	heat shock protein binding
B5U27_RS26805	COG4215	(ABC) transporter
B5U27_RS26810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5U27_RS26865	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B5U27_RS26870	COG1194	a g-specific adenine glycosylase
B5U27_RS26885	COG2223	nitrite transmembrane transporter activity
B5U27_RS26895	COG1448	Aminotransferase
B5U27_RS26900	COG0131	Imidazoleglycerol-phosphate dehydratase
B5U27_RS26905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5U27_RS26915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5U27_RS26920	COG0107	imidazoleglycerol-phosphate synthase activity
B5U27_RS26930	COG1724	mRNA binding
B5U27_RS26935	COG1598	PFAM Uncharacterised protein family UPF0150
B5U27_RS26940	COG2861	carbohydrate metabolic process
B5U27_RS26945	COG0793	Belongs to the peptidase S41A family
B5U27_RS26950	COG4942	peptidase
B5U27_RS26955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B5U27_RS26960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5U27_RS26970	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B5U27_RS26975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B5U27_RS26985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5U27_RS26990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B5U27_RS26995	COG4521	taurine ABC transporter
B5U27_RS27005	COG0450	alkyl hydroperoxide reductase
B5U27_RS27015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS27020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5U27_RS27025	COG1116	anion transmembrane transporter activity
B5U27_RS27045	COG0174	glutamine synthetase
B5U27_RS27050	COG0174	glutamine synthetase
B5U27_RS27070	COG3842	ATPase activity
B5U27_RS27075	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5U27_RS27080	COG1177	transmembrane transport
B5U27_RS27110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5U27_RS27115	COG0277	FAD linked oxidase domain protein
B5U27_RS27120	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5U27_RS27135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B5U27_RS27140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5U27_RS27155	COG0494	nUDIX hydrolase
B5U27_RS27160	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B5U27_RS27175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5U27_RS27180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5U27_RS27195	COG0789	Transcriptional regulator
B5U27_RS27210	COG1228	amidohydrolase
B5U27_RS27220	COG2986	histidine ammonia-lyase
B5U27_RS27225	COG2986	histidine ammonia-lyase
B5U27_RS27230	COG0517	IMP dehydrogenase activity
B5U27_RS27230	COG4175	Glycine betaine
B5U27_RS27235	COG4176	ABC-type proline glycine betaine transport system permease component
B5U27_RS27245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B5U27_RS27255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5U27_RS27260	COG1609	Transcriptional regulator
B5U27_RS27265	COG4771	TonB-dependent receptor
B5U27_RS27270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5U27_RS27275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5U27_RS27280	COG0667	Aldo Keto reductase
B5U27_RS27290	COG3852	Histidine kinase
B5U27_RS27325	COG0301	tRNA thio-modification
B5U27_RS27325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5U27_RS27330	COG1217	gtp-binding protein TYPA
B5U27_RS27335	COG1349	DNA-binding transcription factor activity
B5U27_RS27420	COG1733	regulation of RNA biosynthetic process
B5U27_RS27470	COG2026	Addiction module toxin, RelE StbE family
B5U27_RS27475	COG3077	Addiction module antitoxin, RelB DinJ family
B5U27_RS27505	COG2957	Belongs to the agmatine deiminase family
B5U27_RS27515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5U27_RS27545	COG1218	3'(2'),5'-bisphosphate nucleotidase
B5U27_RS27550	COG0494	nUDIX hydrolase
B5U27_RS27555	COG1011	Hydrolase
B5U27_RS27560	COG0583	DNA-binding transcription factor activity
B5U27_RS27565	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5U27_RS27570	COG0243	molybdopterin cofactor binding
B5U27_RS27690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS27730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5U27_RS27735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5U27_RS27740	COG1234	tRNA 3'-trailer cleavage
B5U27_RS27780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5U27_RS27800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5U27_RS27805	COG0667	Aldo Keto reductase
B5U27_RS27810	COG1802	Transcriptional regulator
B5U27_RS27825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B5U27_RS27875	COG1960	acyl-CoA dehydrogenase activity
B5U27_RS27880	COG0583	DNA-binding transcription factor activity
B5U27_RS27900	COG0427	acetyl-CoA hydrolase
B5U27_RS27955	COG3161	chorismate lyase activity
B5U27_RS27960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5U27_RS27975	COG1253	flavin adenine dinucleotide binding
B5U27_RS27990	COG0739	heme binding
B5U27_RS28000	COG0704	Plays a role in the regulation of phosphate uptake
B5U27_RS28005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5U27_RS28010	COG0581	inorganic phosphate transmembrane transporter activity
B5U27_RS28015	COG0573	inorganic phosphate transmembrane transporter activity
B5U27_RS28065	COG0583	DNA-binding transcription factor activity
B5U27_RS28070	COG1027	Aspartate ammonia-lyase
B5U27_RS28075	COG1115	amino acid carrier protein
B5U27_RS28080	COG0252	asparaginase activity
B5U27_RS28085	COG3781	membrane
B5U27_RS28090	COG2391	methyltransferase activity
B5U27_RS28115	COG5016	pyruvate
B5U27_RS28115	COG0511	ligase activity, forming carbon-carbon bonds
B5U27_RS28120	COG0439	Biotin carboxylase
B5U27_RS28125	COG0583	DNA-binding transcription factor activity
B5U27_RS28140	COG0210	DNA helicase
B5U27_RS28155	COG4651	solute:proton antiporter activity
B5U27_RS28155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5U27_RS28160	COG1607	acyl-coa hydrolase
B5U27_RS28165	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B5U27_RS28175	COG0523	cobalamin synthesis protein
B5U27_RS28210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5U27_RS28220	COG2184	nucleotidyltransferase activity
B5U27_RS28225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B5U27_RS28255	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B5U27_RS28275	COG4566	intracellular signal transduction
B5U27_RS28280	COG4191	Histidine kinase
B5U27_RS28285	COG1116	anion transmembrane transporter activity
B5U27_RS28300	COG0840	transmembrane signaling receptor activity
B5U27_RS28315	COG3546	catalase activity
B5U27_RS28330	COG0529	Catalyzes the synthesis of activated sulfate
B5U27_RS28340	COG2890	protein-(glutamine-N5) methyltransferase activity
B5U27_RS28355	COG1120	ATPase activity
B5U27_RS28365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5U27_RS28375	COG1653	transport
B5U27_RS28395	COG1621	beta-fructofuranosidase activity
B5U27_RS28410	COG2814	Major facilitator Superfamily
B5U27_RS28430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B5U27_RS28435	COG1349	DNA-binding transcription factor activity
B5U27_RS28440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5U27_RS28445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5U27_RS28450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5U27_RS28455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5U27_RS28460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5U27_RS28465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5U27_RS28470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5U27_RS28480	COG0356	it plays a direct role in the translocation of protons across the membrane
B5U27_RS28485	COG3312	ion transport
B5U27_RS28490	COG1475	DNA binding
B5U27_RS28495	COG1192	Involved in chromosome partitioning
B5U27_RS28500	COG0357	Ribosomal RNA small subunit methyltransferase G
B5U27_RS28505	COG0445	tRNA wobble uridine modification
B5U27_RS28510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B5U27_RS28515	COG0706	membrane insertase activity
B5U27_RS28520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5U27_RS28525	COG0594	ribonuclease P activity
B5U27_RS28530	COG0230	Belongs to the bacterial ribosomal protein bL34 family