locus-tag	class	description
A7J50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7J50_RS00010	COG0592	DNA-directed DNA polymerase activity
A7J50_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7J50_RS00020	COG0187	DNA topoisomerase II activity
A7J50_RS00040	COG0745	RESPONSE REGULATOR receiver
A7J50_RS00050	COG5002	protein histidine kinase activity
A7J50_RS00060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7J50_RS00065	COG0751	glycine-tRNA ligase activity
A7J50_RS00070	COG0752	glycyl-tRNA synthetase alpha subunit
A7J50_RS00075	COG2818	Glycosylase
A7J50_RS00090	COG0569	domain protein
A7J50_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7J50_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7J50_RS00105	COG0242	peptide deformylase activity
A7J50_RS00115	COG0758	DNA mediated transformation
A7J50_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
A7J50_RS00130	COG0408	coproporphyrinogen oxidase activity
A7J50_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7J50_RS00150	COG3119	arylsulfatase activity
A7J50_RS00155	COG0583	DNA-binding transcription factor activity
A7J50_RS00165	COG3734	2-keto-3-deoxy-galactonokinase
A7J50_RS00170	COG0800	Aldolase
A7J50_RS00175	COG4948	Mandelate Racemase Muconate Lactonizing
A7J50_RS00180	COG2271	Major facilitator Superfamily
A7J50_RS00190	COG0159	tryptophan synthase activity
A7J50_RS00210	COG3360	Dodecin
A7J50_RS00220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J50_RS00225	COG1764	response to oxidative stress
A7J50_RS00250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A7J50_RS00255	COG0339	signal peptide processing
A7J50_RS00295	COG0659	secondary active sulfate transmembrane transporter activity
A7J50_RS00305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7J50_RS00310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7J50_RS00315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A7J50_RS00345	COG0109	protoheme IX farnesyltransferase activity
A7J50_RS00365	COG2011	ABC-type metal ion transport system permease component
A7J50_RS00370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7J50_RS00385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7J50_RS00390	COG1121	(ABC) transporter
A7J50_RS00395	COG0735	belongs to the Fur family
A7J50_RS00400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A7J50_RS00420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7J50_RS00425	COG3245	cytochrome
A7J50_RS00435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7J50_RS00450	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7J50_RS00455	COG5002	protein histidine kinase activity
A7J50_RS00460	COG2204	response regulator
A7J50_RS00475	COG1301	dicarboxylic acid transport
A7J50_RS00480	COG0700	Nucleoside recognition
A7J50_RS00495	COG1127	ABC transporter
A7J50_RS00500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7J50_RS00510	COG0612	Peptidase, M16
A7J50_RS00515	COG1283	sodium-dependent phosphate transmembrane transporter activity
A7J50_RS00520	COG0861	Integral membrane protein TerC family
A7J50_RS00525	COG2851	Citrate transporter
A7J50_RS00555	COG0427	acetyl-CoA hydrolase
A7J50_RS00575	COG0583	DNA-binding transcription factor activity
A7J50_RS00620	COG0840	transmembrane signaling receptor activity
A7J50_RS00655	COG3300	MHYT domain
A7J50_RS00655	COG5001	Diguanylate cyclase
A7J50_RS00675	COG2274	protein secretion by the type I secretion system
A7J50_RS00680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS00685	COG2175	clavaminate synthase activity
A7J50_RS00695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J50_RS00795	COG1289	transmembrane transporter activity
A7J50_RS00805	COG1566	PFAM secretion protein HlyD family protein
A7J50_RS00820	COG5339	Protein conserved in bacteria
A7J50_RS00825	COG0457	Tetratricopeptide repeat
A7J50_RS00830	COG0726	polysaccharide deacetylase
A7J50_RS00830	COG1649	PFAM Uncharacterised BCR, COG1649
A7J50_RS00835	COG1215	transferase activity, transferring glycosyl groups
A7J50_RS00850	COG3210	domain, Protein
A7J50_RS00930	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A7J50_RS00935	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A7J50_RS00940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A7J50_RS00945	COG2304	oxidoreductase activity
A7J50_RS00950	COG1595	DNA-templated transcription, initiation
A7J50_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS00975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J50_RS00985	COG2199	diguanylate cyclase activity
A7J50_RS01005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7J50_RS01015	COG4208	sulfate ABC transporter
A7J50_RS01020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A7J50_RS01030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7J50_RS01055	COG2807	transmembrane transport
A7J50_RS01060	COG0590	tRNA wobble adenosine to inosine editing
A7J50_RS01065	COG0583	DNA-binding transcription factor activity
A7J50_RS01100	COG0765	amino acid transport
A7J50_RS01105	COG0765	amino acid transport
A7J50_RS01110	COG1126	abc transporter atp-binding protein
A7J50_RS01115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS01135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J50_RS01150	COG2011	ABC-type metal ion transport system permease component
A7J50_RS01155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7J50_RS01185	COG1126	abc transporter atp-binding protein
A7J50_RS01190	COG0765	amino acid transport
A7J50_RS01195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS01205	COG1045	serine acetyltransferase
A7J50_RS01210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7J50_RS01220	COG0667	Aldo Keto reductase
A7J50_RS01225	COG2175	clavaminate synthase activity
A7J50_RS01230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J50_RS01235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7J50_RS01240	COG4521	taurine ABC transporter
A7J50_RS01245	COG2918	glutathione biosynthetic process
A7J50_RS01255	COG2183	response to ionizing radiation
A7J50_RS01270	COG0189	ligase activity
A7J50_RS01275	COG0189	ligase activity
A7J50_RS01275	COG4067	protein conserved in archaea
A7J50_RS01280	COG3287	FIST C domain
A7J50_RS01280	COG2200	EAL domain
A7J50_RS01280	COG2199	diguanylate cyclase activity
A7J50_RS01285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7J50_RS01295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7J50_RS01300	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7J50_RS01305	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7J50_RS01330	COG2184	nucleotidyltransferase activity
A7J50_RS01340	COG0514	ATP-dependent DNA helicase (RecQ)
A7J50_RS01345	COG0824	Thioesterase
A7J50_RS01355	COG0243	molybdopterin cofactor binding
A7J50_RS01370	COG1652	LysM domain
A7J50_RS01375	COG1011	Hydrolase
A7J50_RS01380	COG0494	nUDIX hydrolase
A7J50_RS01385	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7J50_RS01415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J50_RS01420	COG2957	Belongs to the agmatine deiminase family
A7J50_RS01465	COG0582	viral genome integration into host DNA
A7J50_RS01475	COG1192	Involved in chromosome partitioning
A7J50_RS01545	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A7J50_RS01550	COG1194	a g-specific adenine glycosylase
A7J50_RS01560	COG2223	nitrite transmembrane transporter activity
A7J50_RS01575	COG0131	Imidazoleglycerol-phosphate dehydratase
A7J50_RS01580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7J50_RS01590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7J50_RS01595	COG0107	imidazoleglycerol-phosphate synthase activity
A7J50_RS01605	COG2861	carbohydrate metabolic process
A7J50_RS01610	COG0793	Belongs to the peptidase S41A family
A7J50_RS01615	COG4942	peptidase
A7J50_RS01620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A7J50_RS01625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J50_RS01635	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A7J50_RS01655	COG3852	Histidine kinase
A7J50_RS01675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J50_RS01675	COG0301	tRNA thio-modification
A7J50_RS01680	COG1217	gtp-binding protein TYPA
A7J50_RS01690	COG0058	SHG alpha-glucan phosphorylase activity
A7J50_RS01705	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7J50_RS01715	COG3040	lipid binding
A7J50_RS01720	COG0402	S-adenosylhomocysteine deaminase activity
A7J50_RS01725	COG2188	Transcriptional regulator
A7J50_RS01735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A7J50_RS01740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7J50_RS01750	COG4176	ABC-type proline glycine betaine transport system permease component
A7J50_RS01755	COG4175	Glycine betaine
A7J50_RS01755	COG0517	IMP dehydrogenase activity
A7J50_RS01760	COG2986	histidine ammonia-lyase
A7J50_RS01765	COG2986	histidine ammonia-lyase
A7J50_RS01770	COG1113	amino acid transport
A7J50_RS01775	COG1228	amidohydrolase
A7J50_RS01790	COG0657	acetylesterase activity
A7J50_RS01795	COG0596	Alpha beta hydrolase
A7J50_RS01800	COG1490	D-aminoacyl-tRNA deacylase activity
A7J50_RS01805	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A7J50_RS01810	COG2943	transferase activity, transferring hexosyl groups
A7J50_RS01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS01820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS01825	COG0765	amino acid transport
A7J50_RS01830	COG1126	abc transporter atp-binding protein
A7J50_RS01835	COG0840	transmembrane signaling receptor activity
A7J50_RS01840	COG0840	transmembrane signaling receptor activity
A7J50_RS01855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7J50_RS01860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7J50_RS01865	COG0140	phosphoribosyl-ATP diphosphatase activity
A7J50_RS01870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7J50_RS01875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7J50_RS01885	COG2226	methyltransferase
A7J50_RS01930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A7J50_RS01935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7J50_RS01945	COG0018	arginyl-trna synthetase
A7J50_RS01950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7J50_RS01955	COG0254	rRNA binding
A7J50_RS01960	COG0281	malic enzyme
A7J50_RS01990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7J50_RS01995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7J50_RS02010	COG0070	glutamate synthase
A7J50_RS02010	COG0069	glutamate synthase activity
A7J50_RS02010	COG0067	glutamate synthase
A7J50_RS02015	COG0493	'glutamate synthase
A7J50_RS02020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7J50_RS02025	COG2814	Major facilitator Superfamily
A7J50_RS02030	COG0583	DNA-binding transcription factor activity
A7J50_RS02040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J50_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS02055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J50_RS02065	COG2226	methyltransferase
A7J50_RS02090	COG2986	histidine ammonia-lyase
A7J50_RS02105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7J50_RS02115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J50_RS02120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J50_RS02135	COG1192	Involved in chromosome partitioning
A7J50_RS02145	COG3118	belongs to the thioredoxin family
A7J50_RS02150	COG4680	protein conserved in bacteria
A7J50_RS02155	COG5499	transcription regulator containing HTH domain
A7J50_RS02160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7J50_RS02165	COG3264	Mechanosensitive ion channel
A7J50_RS02165	COG1196	nuclear chromosome segregation
A7J50_RS02170	COG3263	regulation of cellular component size
A7J50_RS02190	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS02195	COG0506	proline dehydrogenase activity
A7J50_RS02195	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7J50_RS02195	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7J50_RS02200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J50_RS02215	COG2873	o-acetylhomoserine
A7J50_RS02220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A7J50_RS02225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J50_RS02245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7J50_RS02250	COG0859	PFAM glycosyl transferase family 9
A7J50_RS02255	COG0859	PFAM glycosyl transferase family 9
A7J50_RS02260	COG0438	transferase activity, transferring glycosyl groups
A7J50_RS02285	COG4772	TonB-dependent receptor
A7J50_RS02300	COG2192	nodulation
A7J50_RS02330	COG1215	transferase activity, transferring glycosyl groups
A7J50_RS02340	COG1132	(ABC) transporter
A7J50_RS02350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7J50_RS02350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7J50_RS02355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J50_RS02365	COG0667	Aldo Keto reductase
A7J50_RS02385	COG1519	Transferase
A7J50_RS02390	COG1538	Outer membrane efflux protein
A7J50_RS02395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7J50_RS02410	COG0494	nUDIX hydrolase
A7J50_RS02420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7J50_RS02425	COG3150	esterase
A7J50_RS02460	COG0560	Phosphoserine phosphatase
A7J50_RS02460	COG3830	Belongs to the UPF0237 family
A7J50_RS02465	COG0688	phosphatidylethanolamine metabolic process
A7J50_RS02490	COG1162	GTPase activity
A7J50_RS02495	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A7J50_RS02500	COG2860	membrane
A7J50_RS02510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7J50_RS02510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7J50_RS02515	COG0802	atpase or kinase
A7J50_RS02520	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7J50_RS02525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7J50_RS02530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7J50_RS02535	COG1923	regulation of RNA biosynthetic process
A7J50_RS02540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7J50_RS02545	COG0330	HflC and HflK could
A7J50_RS02550	COG0330	HflC and HflK could
A7J50_RS02555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A7J50_RS02560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7J50_RS02570	COG1178	ABC-type Fe3 transport system permease component
A7J50_RS02575	COG1840	ABC-type Fe3 transport system, periplasmic component
A7J50_RS02590	COG0557	exoribonuclease II activity
A7J50_RS02595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7J50_RS02600	COG0360	Binds together with S18 to 16S ribosomal RNA
A7J50_RS02605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7J50_RS02615	COG0359	binds to the 23S rRNA
A7J50_RS02620	COG0305	Participates in initiation and elongation during chromosome replication
A7J50_RS02625	COG1032	radical SAM domain protein
A7J50_RS02645	COG2308	Evidence 4 Homologs of previously reported genes of
A7J50_RS02645	COG2307	Protein conserved in bacteria
A7J50_RS02665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7J50_RS02670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7J50_RS02675	COG0583	DNA-binding transcription factor activity
A7J50_RS02680	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS02685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS02695	COG0559	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS02715	COG4221	oxidoreductase activity
A7J50_RS02735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7J50_RS02740	COG0830	nickel cation binding
A7J50_RS02745	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A7J50_RS02750	COG1309	transcriptional regulator
A7J50_RS02760	COG2982	Protein involved in outer membrane biogenesis
A7J50_RS02770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A7J50_RS02775	COG0697	spore germination
A7J50_RS02800	COG0443	Heat shock 70 kDa protein
A7J50_RS02805	COG0484	heat shock protein binding
A7J50_RS02820	COG0804	urea catabolic process
A7J50_RS02825	COG0832	Belongs to the urease beta subunit family
A7J50_RS02840	COG0831	urea catabolic process
A7J50_RS02845	COG0829	nickel cation binding
A7J50_RS02855	COG0411	ABC transporter
A7J50_RS02870	COG0683	leucine binding
A7J50_RS02880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J50_RS02890	COG1120	ATPase activity
A7J50_RS02935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7J50_RS02960	COG2095	MarC family integral membrane protein
A7J50_RS02970	COG0151	Belongs to the GarS family
A7J50_RS02975	COG0138	bifunctional purine biosynthesis protein purh
A7J50_RS02985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7J50_RS02995	COG2264	protein methyltransferase activity
A7J50_RS03010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7J50_RS03035	COG0023	Translation Initiation Factor
A7J50_RS03040	COG1166	arginine decarboxylase activity
A7J50_RS03055	COG0534	Mate efflux family protein
A7J50_RS03070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7J50_RS03140	COG4964	Belongs to the GSP D family
A7J50_RS03180	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS03200	COG2217	Heavy metal translocating P-type atpase
A7J50_RS03215	COG2814	Major facilitator Superfamily
A7J50_RS03225	COG0604	alcohol dehydrogenase
A7J50_RS03230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A7J50_RS03235	COG0583	DNA-binding transcription factor activity
A7J50_RS03245	COG0477	Major facilitator Superfamily
A7J50_RS03250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7J50_RS03255	COG0387	Pfam Sodium calcium exchanger
A7J50_RS03275	COG1309	transcriptional regulator
A7J50_RS03280	COG2233	PERMEase
A7J50_RS03325	COG2995	paraquat-inducible protein a
A7J50_RS03330	COG2995	paraquat-inducible protein a
A7J50_RS03335	COG3008	intermembrane lipid transfer
A7J50_RS03360	COG0456	acetyltransferase
A7J50_RS03370	COG0288	reversible hydration of carbon dioxide
A7J50_RS03390	COG2031	fatty acid transporter
A7J50_RS03395	COG0477	Major facilitator Superfamily
A7J50_RS03450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7J50_RS03465	COG3655	Transcriptional regulator
A7J50_RS03485	COG0405	Gamma-glutamyltransferase
A7J50_RS03565	COG0582	viral genome integration into host DNA
A7J50_RS03600	COG1157	protein secretion by the type III secretion system
A7J50_RS03615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7J50_RS03625	COG4794	Type iii secretion
A7J50_RS03635	COG4792	protein secretion
A7J50_RS03675	COG4669	(LipO)protein
A7J50_RS03700	COG0193	aminoacyl-tRNA hydrolase activity
A7J50_RS03705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7J50_RS03710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7J50_RS03720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7J50_RS03725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A7J50_RS03735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7J50_RS03740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7J50_RS03750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7J50_RS03755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7J50_RS03775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7J50_RS03790	COG4221	oxidoreductase activity
A7J50_RS03800	COG0415	Belongs to the DNA photolyase family
A7J50_RS03805	COG0789	Transcriptional regulator
A7J50_RS03820	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A7J50_RS03825	COG1090	epimerase
A7J50_RS03830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7J50_RS03845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J50_RS03855	COG0175	sulfate reduction
A7J50_RS03865	COG0204	Acyl-transferase
A7J50_RS03870	COG0280	phosphate acetyltransferase
A7J50_RS03870	COG0857	belongs to the CobB CobQ family
A7J50_RS03885	COG0268	Binds directly to 16S ribosomal RNA
A7J50_RS03895	COG0196	riboflavin kinase activity
A7J50_RS03900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7J50_RS03905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7J50_RS03910	COG1047	Peptidyl-prolyl cis-trans
A7J50_RS03915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7J50_RS03945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS03970	COG0542	response to heat
A7J50_RS03995	COG1252	NADH dehydrogenase
A7J50_RS04020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A7J50_RS04025	COG0237	dephospho-CoA kinase activity
A7J50_RS04030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A7J50_RS04065	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7J50_RS04085	COG0084	hydrolase, TatD family'
A7J50_RS04090	COG1609	Transcriptional regulator
A7J50_RS04100	COG1105	Belongs to the carbohydrate kinase PfkB family
A7J50_RS04105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7J50_RS04105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7J50_RS04105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7J50_RS04115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7J50_RS04120	COG4774	siderophore transport
A7J50_RS04125	COG3128	pkhd-type hydroxylase
A7J50_RS04135	COG0019	diaminopimelate decarboxylase activity
A7J50_RS04160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7J50_RS04175	COG4608	Belongs to the ABC transporter superfamily
A7J50_RS04180	COG0444	Belongs to the ABC transporter superfamily
A7J50_RS04185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J50_RS04190	COG0601	transmembrane transport
A7J50_RS04195	COG0747	negative chemotaxis
A7J50_RS04205	COG0747	negative chemotaxis
A7J50_RS04210	COG0747	negative chemotaxis
A7J50_RS04215	COG0747	negative chemotaxis
A7J50_RS04235	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A7J50_RS04240	COG4178	(ABC) transporter
A7J50_RS04255	COG0180	Tryptophanyl-tRNA synthetase
A7J50_RS04260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7J50_RS04275	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS04280	COG0667	Aldo Keto reductase
A7J50_RS04285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7J50_RS04290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7J50_RS04295	COG0723	plastoquinol--plastocyanin reductase activity
A7J50_RS04300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A7J50_RS04305	COG2857	Cytochrome c1
A7J50_RS04310	COG0625	glutathione transferase activity
A7J50_RS04315	COG2969	positive regulation of protein catabolic process
A7J50_RS04320	COG2186	Transcriptional regulator
A7J50_RS04330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J50_RS04340	COG2271	Major facilitator Superfamily
A7J50_RS04345	COG2721	sulfolactate sulfo-lyase activity
A7J50_RS04355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J50_RS04365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7J50_RS04370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7J50_RS04375	COG0154	amidase activity
A7J50_RS04380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7J50_RS04385	COG1077	Cell shape determining protein MreB Mrl
A7J50_RS04390	COG1792	Involved in formation and maintenance of cell shape
A7J50_RS04400	COG0424	maF-like protein
A7J50_RS04405	COG1530	ribonuclease E activity
A7J50_RS04415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J50_RS04420	COG0312	modulator of DNA gyrase
A7J50_RS04425	COG3028	Belongs to the UPF0307 family
A7J50_RS04430	COG0312	modulator of DNA gyrase
A7J50_RS04465	COG1660	Displays ATPase and GTPase activities
A7J50_RS04475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7J50_RS04480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7J50_RS04485	COG1137	ATPase activity
A7J50_RS04490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A7J50_RS04500	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7J50_RS04510	COG1127	ABC transporter
A7J50_RS04515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7J50_RS04520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7J50_RS04540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7J50_RS04545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7J50_RS04550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7J50_RS04555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7J50_RS04565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7J50_RS04570	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7J50_RS04630	COG2135	peptidase activity
A7J50_RS04635	COG0501	Belongs to the peptidase M48B family
A7J50_RS04640	COG2119	membrane
A7J50_RS04645	COG2813	Specifically methylates the guanine in position
A7J50_RS04650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7J50_RS04655	COG1280	lysine exporter protein (LysE YggA)
A7J50_RS04660	COG0318	PFAM AMP-dependent synthetase and ligase
A7J50_RS04675	COG2909	trisaccharide binding
A7J50_RS04685	COG3008	intermembrane lipid transfer
A7J50_RS04690	COG2995	paraquat-inducible protein a
A7J50_RS04700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7J50_RS04705	COG2885	chlorophyll binding
A7J50_RS04710	COG2823	Periplasmic or secreted lipoprotein
A7J50_RS04715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7J50_RS04720	COG0792	nuclease activity
A7J50_RS04740	COG2001	Belongs to the MraZ family
A7J50_RS04745	COG0275	rRNA processing
A7J50_RS04760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7J50_RS04765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7J50_RS04770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7J50_RS04775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7J50_RS04780	COG0772	Belongs to the SEDS family
A7J50_RS04785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7J50_RS04790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7J50_RS04795	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7J50_RS04810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7J50_RS04815	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7J50_RS04820	COG5001	Diguanylate cyclase
A7J50_RS04820	COG4251	negative regulation of phosphorylation
A7J50_RS04820	COG3706	GGDEF domain
A7J50_RS04820	COG2203	Gaf domain
A7J50_RS04825	COG3706	GGDEF domain
A7J50_RS04825	COG5001	Diguanylate cyclase
A7J50_RS04825	COG4251	negative regulation of phosphorylation
A7J50_RS04825	COG2203	Gaf domain
A7J50_RS04835	COG5002	protein histidine kinase activity
A7J50_RS04860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS04875	COG0784	Response regulator, receiver
A7J50_RS04875	COG0835	chemotaxis
A7J50_RS04880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7J50_RS04890	COG0583	DNA-binding transcription factor activity
A7J50_RS04910	COG1566	PFAM secretion protein HlyD family protein
A7J50_RS04930	COG0300	oxidoreductase activity
A7J50_RS04950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A7J50_RS04950	COG0662	Cupin 2, conserved barrel domain protein
A7J50_RS04965	COG1696	Membrane protein involved in D-alanine export
A7J50_RS04980	COG3420	alginic acid biosynthetic process
A7J50_RS04990	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A7J50_RS04995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS05000	COG1215	transferase activity, transferring glycosyl groups
A7J50_RS05010	COG3022	response to hydroperoxide
A7J50_RS05020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7J50_RS05030	COG0315	cyclic pyranopterin monophosphate synthase activity
A7J50_RS05035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A7J50_RS05045	COG0513	Belongs to the DEAD box helicase family
A7J50_RS05050	COG0400	carboxylic ester hydrolase activity
A7J50_RS05055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS05060	COG4597	amino acid ABC transporter
A7J50_RS05065	COG0765	amino acid transport
A7J50_RS05070	COG1126	abc transporter atp-binding protein
A7J50_RS05085	COG2186	Transcriptional regulator
A7J50_RS05090	COG2807	transmembrane transport
A7J50_RS05095	COG3539	Fimbrial protein
A7J50_RS05110	COG3188	usher protein
A7J50_RS05115	COG3121	Chaperone
A7J50_RS05125	COG3539	Fimbrial protein
A7J50_RS05135	COG2205	protein histidine kinase activity
A7J50_RS05135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS05145	COG3539	Fimbrial protein
A7J50_RS05150	COG3539	Fimbrial protein
A7J50_RS05155	COG3539	Fimbrial protein
A7J50_RS05165	COG2827	Endonuclease containing a URI domain
A7J50_RS05175	COG4774	siderophore transport
A7J50_RS05180	COG2027	D-alanyl-D-alanine carboxypeptidase
A7J50_RS05190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A7J50_RS05195	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7J50_RS05215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7J50_RS05245	COG0814	amino acid
A7J50_RS05250	COG1760	l-serine dehydratase
A7J50_RS05255	COG0583	DNA-binding transcription factor activity
A7J50_RS05265	COG0477	Major facilitator Superfamily
A7J50_RS05275	COG4772	TonB-dependent receptor
A7J50_RS05280	COG3712	iron ion homeostasis
A7J50_RS05285	COG1595	DNA-templated transcription, initiation
A7J50_RS05320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7J50_RS05325	COG3081	Nucleoid-associated protein
A7J50_RS05335	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A7J50_RS05340	COG0525	valine-tRNA ligase activity
A7J50_RS05355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7J50_RS05360	COG0795	lipopolysaccharide-transporting ATPase activity
A7J50_RS05365	COG0795	lipopolysaccharide-transporting ATPase activity
A7J50_RS05370	COG0481	GTPase activity
A7J50_RS05375	COG0681	Belongs to the peptidase S26 family
A7J50_RS05380	COG0571	ribonuclease III activity
A7J50_RS05385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7J50_RS05390	COG1381	Involved in DNA repair and RecF pathway recombination
A7J50_RS05395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7J50_RS05405	COG0590	tRNA wobble adenosine to inosine editing
A7J50_RS05410	COG0500	methyltransferase
A7J50_RS05415	COG2226	methyltransferase
A7J50_RS05430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7J50_RS05460	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS05470	COG0523	cobalamin synthesis protein
A7J50_RS05490	COG4206	TonB-dependent receptor
A7J50_RS05495	COG4628	conserved protein (DUF2132)
A7J50_RS05505	COG2375	cellular response to nickel ion
A7J50_RS05510	COG1695	Transcriptional regulator
A7J50_RS05525	COG3188	usher protein
A7J50_RS05530	COG3121	Chaperone
A7J50_RS05545	COG3539	Fimbrial protein
A7J50_RS05550	COG3539	Fimbrial protein
A7J50_RS05575	COG1113	amino acid transport
A7J50_RS05590	COG0069	glutamate synthase activity
A7J50_RS05595	COG2197	response regulator
A7J50_RS05605	COG0531	amino acid
A7J50_RS05610	COG0254	rRNA binding
A7J50_RS05620	COG4191	Histidine kinase
A7J50_RS05625	COG1858	cytochrome C peroxidase
A7J50_RS05635	COG2204	response regulator
A7J50_RS05650	COG0583	DNA-binding transcription factor activity
A7J50_RS05675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J50_RS05690	COG4191	Histidine kinase
A7J50_RS05695	COG2204	response regulator
A7J50_RS05715	COG1126	abc transporter atp-binding protein
A7J50_RS05720	COG0765	amino acid transport
A7J50_RS05725	COG0765	amino acid transport
A7J50_RS05730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS05745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7J50_RS05755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7J50_RS05760	COG3842	ATPase activity
A7J50_RS05765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7J50_RS05770	COG0243	molybdopterin cofactor binding
A7J50_RS05775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A7J50_RS05790	COG0450	alkyl hydroperoxide reductase
A7J50_RS05795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7J50_RS05800	COG0418	dihydroorotase activity
A7J50_RS05810	COG0137	argininosuccinate synthase activity
A7J50_RS05815	COG2197	response regulator
A7J50_RS05825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7J50_RS05830	COG2878	Part of a membrane complex involved in electron transport
A7J50_RS05835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J50_RS05835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7J50_RS05840	COG0489	protein tyrosine kinase activity
A7J50_RS05850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7J50_RS05950	COG1484	DNA-dependent DNA replication
A7J50_RS05955	COG0305	Participates in initiation and elongation during chromosome replication
A7J50_RS06115	COG3179	chitinase
A7J50_RS06215	COG3179	chitinase
A7J50_RS06220	COG1546	Belongs to the CinA family
A7J50_RS06225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7J50_RS06230	COG2137	regulation of response to DNA damage stimulus
A7J50_RS06245	COG3148	PFAM DTW domain containing protein
A7J50_RS06260	COG0583	DNA-binding transcription factor activity
A7J50_RS06275	COG4807	Protein conserved in bacteria
A7J50_RS06290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7J50_RS06325	COG3158	transport of potassium into the cell
A7J50_RS06330	COG1902	pentaerythritol trinitrate reductase activity
A7J50_RS06340	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A7J50_RS06360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7J50_RS06360	COG0457	Tetratricopeptide repeat
A7J50_RS06375	COG2201	protein-glutamate methylesterase activity
A7J50_RS06380	COG5001	Diguanylate cyclase
A7J50_RS06380	COG4251	negative regulation of phosphorylation
A7J50_RS06380	COG3706	GGDEF domain
A7J50_RS06380	COG2203	Gaf domain
A7J50_RS06390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7J50_RS06395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7J50_RS06415	COG1073	alpha beta
A7J50_RS06425	COG2885	chlorophyll binding
A7J50_RS06440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7J50_RS06445	COG0563	adenylate kinase activity
A7J50_RS06450	COG1214	PFAM Peptidase M22, glycoprotease
A7J50_RS06460	COG1801	Protein of unknown function DUF72
A7J50_RS06480	COG0742	ribosomal rna small subunit methyltransferase
A7J50_RS06490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS06495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J50_RS06515	COG2937	Belongs to the GPAT DAPAT family
A7J50_RS06530	COG2226	methyltransferase
A7J50_RS06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7J50_RS06540	COG1215	transferase activity, transferring glycosyl groups
A7J50_RS06545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7J50_RS06550	COG2166	iron-sulfur cluster assembly
A7J50_RS06555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7J50_RS06560	COG2171	N-acyltransferase activity
A7J50_RS06565	COG1393	Belongs to the ArsC family
A7J50_RS06570	COG0582	viral genome integration into host DNA
A7J50_RS06765	COG1484	DNA-dependent DNA replication
A7J50_RS06855	COG5484	DNA packaging
A7J50_RS06855	COG3728	DNA packaging
A7J50_RS06965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A7J50_RS07020	COG0025	NhaP-type Na H and K H
A7J50_RS07045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7J50_RS07050	COG0024	Methionine aminopeptidase
A7J50_RS07055	COG0052	Belongs to the universal ribosomal protein uS2 family
A7J50_RS07060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7J50_RS07065	COG0528	UMP kinase activity
A7J50_RS07070	COG0233	cytoplasmic translational termination
A7J50_RS07075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7J50_RS07085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7J50_RS07105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7J50_RS07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7J50_RS07115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7J50_RS07120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7J50_RS07125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7J50_RS07130	COG0587	DNA-directed DNA polymerase activity
A7J50_RS07135	COG0825	malonyl-CoA metabolic process
A7J50_RS07140	COG0037	tRNA processing
A7J50_RS07145	COG0504	CTP synthase activity
A7J50_RS07150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A7J50_RS07155	COG0148	phosphopyruvate hydratase activity
A7J50_RS07165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7J50_RS07175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A7J50_RS07180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A7J50_RS07185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7J50_RS07190	COG0585	pseudouridine synthase activity
A7J50_RS07195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A7J50_RS07200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7J50_RS07210	COG1278	Cold shock
A7J50_RS07215	COG0717	Belongs to the dCTP deaminase family
A7J50_RS07230	COG1201	RNA secondary structure unwinding
A7J50_RS07260	COG1793	dna ligase
A7J50_RS07270	COG2366	antibiotic biosynthetic process
A7J50_RS07275	COG0625	glutathione transferase activity
A7J50_RS07280	COG0653	protein targeting
A7J50_RS07290	COG3012	SEC-C Motif Domain Protein
A7J50_RS07320	COG1199	ATP-dependent helicase activity
A7J50_RS07330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7J50_RS07340	COG0259	pyridoxamine-phosphate oxidase activity
A7J50_RS07355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7J50_RS07365	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A7J50_RS07380	COG0583	DNA-binding transcription factor activity
A7J50_RS07395	COG3220	belongs to the UPF0276 family
A7J50_RS07460	COG0727	PFAM Uncharacterised protein family (UPF0153)
A7J50_RS07465	COG2271	Major facilitator Superfamily
A7J50_RS07470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7J50_RS07490	COG0583	DNA-binding transcription factor activity
A7J50_RS07500	COG0306	phosphate transporter
A7J50_RS07510	COG1414	Transcriptional regulator
A7J50_RS07515	COG2814	Major facilitator Superfamily
A7J50_RS07520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A7J50_RS07525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A7J50_RS07530	COG0183	Belongs to the thiolase family
A7J50_RS07535	COG3485	protocatechuate 3,4-dioxygenase
A7J50_RS07540	COG3485	protocatechuate 3,4-dioxygenase
A7J50_RS07545	COG0477	Major facilitator Superfamily
A7J50_RS07555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7J50_RS07560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J50_RS07590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS07595	COG1309	transcriptional regulator
A7J50_RS07600	COG1902	pentaerythritol trinitrate reductase activity
A7J50_RS07605	COG2814	Major facilitator Superfamily
A7J50_RS07645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J50_RS07655	COG1704	LemA family
A7J50_RS07675	COG0697	spore germination
A7J50_RS07680	COG1629	transport
A7J50_RS07690	COG1595	DNA-templated transcription, initiation
A7J50_RS07695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J50_RS07700	COG0235	Class ii aldolase
A7J50_RS07705	COG1396	sequence-specific DNA binding
A7J50_RS07715	COG1454	alcohol dehydrogenase
A7J50_RS07730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J50_RS07735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7J50_RS07740	COG2271	Major facilitator Superfamily
A7J50_RS07775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7J50_RS07795	COG0583	DNA-binding transcription factor activity
A7J50_RS07800	COG2814	Major facilitator Superfamily
A7J50_RS07810	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A7J50_RS07845	COG2267	carboxylic ester hydrolase activity
A7J50_RS07865	COG0439	Biotin carboxylase
A7J50_RS07870	COG3665	Urea carboxylase-associated protein
A7J50_RS07880	COG3842	ATPase activity
A7J50_RS07905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7J50_RS07940	COG0642	Histidine kinase
A7J50_RS07955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A7J50_RS07985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7J50_RS07995	COG0425	Belongs to the sulfur carrier protein TusA family
A7J50_RS08000	COG0628	permease
A7J50_RS08005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7J50_RS08015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J50_RS08020	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A7J50_RS08025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7J50_RS08030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7J50_RS08045	COG3469	chitinase activity
A7J50_RS08080	COG0583	DNA-binding transcription factor activity
A7J50_RS08125	COG2807	transmembrane transport
A7J50_RS08130	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS08145	COG2910	NAD(P)H-binding
A7J50_RS08155	COG0583	DNA-binding transcription factor activity
A7J50_RS08185	COG0174	glutamine synthetase
A7J50_RS08200	COG3100	YcgL domain-containing protein
A7J50_RS08215	COG2983	Belongs to the UPF0260 family
A7J50_RS08260	COG1770	oligopeptidase
A7J50_RS08270	COG0121	glutamine amidotransferase
A7J50_RS08280	COG0583	DNA-binding transcription factor activity
A7J50_RS08285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7J50_RS08290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7J50_RS08295	COG1984	allophanate hydrolase subunit 2
A7J50_RS08305	COG0542	response to heat
A7J50_RS08320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7J50_RS08335	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A7J50_RS08340	COG0425	Belongs to the sulfur carrier protein TusA family
A7J50_RS08350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J50_RS08355	COG1132	(ABC) transporter
A7J50_RS08365	COG0741	lytic transglycosylase activity
A7J50_RS08370	COG0488	(ABC) transporter
A7J50_RS08375	COG0589	response to stress
A7J50_RS08385	COG1024	Enoyl-CoA hydratase
A7J50_RS08385	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J50_RS08390	COG0183	Belongs to the thiolase family
A7J50_RS08435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7J50_RS08445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7J50_RS08465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J50_RS08470	COG0584	glycerophosphoryl diester phosphodiesterase
A7J50_RS08480	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7J50_RS08485	COG1136	(ABC) transporter
A7J50_RS08490	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7J50_RS08510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7J50_RS08510	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7J50_RS08525	COG2853	Lipoprotein
A7J50_RS08535	COG2204	response regulator
A7J50_RS08545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7J50_RS08550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7J50_RS08750	COG4695	Portal protein
A7J50_RS08810	COG2814	Major facilitator Superfamily
A7J50_RS08815	COG0579	oxidoreductase
A7J50_RS08825	COG0583	DNA-binding transcription factor activity
A7J50_RS08830	COG0583	DNA-binding transcription factor activity
A7J50_RS08860	COG0251	oxidation-reduction process
A7J50_RS08865	COG1611	Belongs to the LOG family
A7J50_RS08875	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7J50_RS08880	COG1011	Hydrolase
A7J50_RS08885	COG0583	DNA-binding transcription factor activity
A7J50_RS08890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J50_RS08895	COG0583	DNA-binding transcription factor activity
A7J50_RS08900	COG2814	Major facilitator Superfamily
A7J50_RS08910	COG2233	PERMEase
A7J50_RS08915	COG2267	carboxylic ester hydrolase activity
A7J50_RS08920	COG2197	response regulator
A7J50_RS08925	COG0596	Alpha beta hydrolase
A7J50_RS08935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J50_RS08940	COG0444	Belongs to the ABC transporter superfamily
A7J50_RS08945	COG4608	Belongs to the ABC transporter superfamily
A7J50_RS08950	COG0747	negative chemotaxis
A7J50_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS08960	COG0546	phosphoglycolate phosphatase activity
A7J50_RS08965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7J50_RS08970	COG0402	S-adenosylhomocysteine deaminase activity
A7J50_RS08975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A7J50_RS08985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7J50_RS08995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7J50_RS09000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7J50_RS09005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7J50_RS09020	COG0776	regulation of translation
A7J50_RS09035	COG2244	polysaccharide biosynthetic process
A7J50_RS09060	COG0438	transferase activity, transferring glycosyl groups
A7J50_RS09080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7J50_RS09085	COG1086	Polysaccharide biosynthesis protein
A7J50_RS09090	COG1555	photosystem II stabilization
A7J50_RS09120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A7J50_RS09130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A7J50_RS09135	COG2205	protein histidine kinase activity
A7J50_RS09140	COG0745	RESPONSE REGULATOR receiver
A7J50_RS09180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7J50_RS09185	COG2259	Doxx family
A7J50_RS09205	COG1131	(ABC) transporter
A7J50_RS09215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7J50_RS09220	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A7J50_RS09225	COG4181	ATPase activity
A7J50_RS09240	COG1376	ErfK ybiS ycfS ynhG family protein
A7J50_RS09270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7J50_RS09305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7J50_RS09310	COG1764	response to oxidative stress
A7J50_RS09315	COG1846	Transcriptional regulator
A7J50_RS09320	COG0583	DNA-binding transcription factor activity
A7J50_RS09325	COG0730	response to heat
A7J50_RS09330	COG0583	DNA-binding transcription factor activity
A7J50_RS09340	COG3214	Protein conserved in bacteria
A7J50_RS09345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A7J50_RS09355	COG1024	Enoyl-CoA hydratase
A7J50_RS09365	COG3384	dioxygenase
A7J50_RS09370	COG0500	methyltransferase
A7J50_RS09375	COG0501	Belongs to the peptidase M48B family
A7J50_RS09380	COG0436	Aminotransferase
A7J50_RS09385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J50_RS09390	COG0386	Belongs to the glutathione peroxidase family
A7J50_RS09395	COG1846	Transcriptional regulator
A7J50_RS09410	COG1956	GAF domain-containing protein
A7J50_RS09415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS09415	COG2205	protein histidine kinase activity
A7J50_RS09420	COG2197	response regulator
A7J50_RS09435	COG5001	Diguanylate cyclase
A7J50_RS09435	COG3300	MHYT domain
A7J50_RS09455	COG0004	ammonium transporteR
A7J50_RS09470	COG0019	diaminopimelate decarboxylase activity
A7J50_RS09475	COG0583	DNA-binding transcription factor activity
A7J50_RS09485	COG0564	pseudouridine synthase activity
A7J50_RS09495	COG0746	molybdenum cofactor guanylyltransferase activity
A7J50_RS09500	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7J50_RS09505	COG0303	'Molybdopterin
A7J50_RS09510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7J50_RS09520	COG4133	protoheme IX ABC transporter activity
A7J50_RS09540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A7J50_RS09545	COG1138	Cytochrome C-type biogenesis protein
A7J50_RS09555	COG3088	subunit of a heme lyase
A7J50_RS09560	COG4235	cytochrome complex assembly
A7J50_RS09570	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A7J50_RS09575	COG0640	Transcriptional regulator
A7J50_RS09595	COG2814	Major facilitator Superfamily
A7J50_RS09605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7J50_RS09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7J50_RS09620	COG0469	pyruvate kinase activity
A7J50_RS09630	COG2084	Dehydrogenase
A7J50_RS09635	COG3622	Belongs to the hyi family
A7J50_RS09640	COG3960	tartronate-semialdehyde synthase activity
A7J50_RS09655	COG1309	transcriptional regulator
A7J50_RS09660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS09670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J50_RS09690	COG2853	Lipoprotein
A7J50_RS09710	COG2113	Glycine betaine
A7J50_RS09715	COG3162	membrane
A7J50_RS09720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J50_RS09730	COG2009	succinate dehydrogenase
A7J50_RS09735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A7J50_RS09740	COG1053	succinate dehydrogenase
A7J50_RS09745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7J50_RS09760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J50_RS09765	COG0045	succinate-CoA ligase (ADP-forming) activity
A7J50_RS09800	COG0326	Molecular chaperone. Has ATPase activity
A7J50_RS09810	COG1741	Belongs to the pirin family
A7J50_RS09835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7J50_RS09840	COG2205	protein histidine kinase activity
A7J50_RS09840	COG5002	protein histidine kinase activity
A7J50_RS09840	COG0784	Response regulator, receiver
A7J50_RS09855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7J50_RS09870	COG1022	Amp-dependent synthetase and ligase
A7J50_RS09895	COG0628	permease
A7J50_RS09910	COG0284	orotidine-5'-phosphate decarboxylase activity
A7J50_RS09915	COG2130	NADP-dependent
A7J50_RS09930	COG0840	transmembrane signaling receptor activity
A7J50_RS09935	COG2267	carboxylic ester hydrolase activity
A7J50_RS09965	COG0786	glutamate:sodium symporter activity
A7J50_RS09980	COG0811	peptide transport
A7J50_RS10005	COG3540	Alkaline phosphatase
A7J50_RS10025	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS10035	COG0625	glutathione transferase activity
A7J50_RS10040	COG1131	(ABC) transporter
A7J50_RS10045	COG0842	Transport permease protein
A7J50_RS10065	COG0477	Major facilitator Superfamily
A7J50_RS10070	COG2076	Multidrug Resistance protein
A7J50_RS10075	COG0385	Bile acid
A7J50_RS10080	COG2974	May be involved in recombination
A7J50_RS10105	COG0477	Major facilitator Superfamily
A7J50_RS10110	COG0583	DNA-binding transcription factor activity
A7J50_RS10115	COG0745	RESPONSE REGULATOR receiver
A7J50_RS10120	COG2205	protein histidine kinase activity
A7J50_RS10125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A7J50_RS10130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A7J50_RS10135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A7J50_RS10150	COG2010	Cytochrome c
A7J50_RS10155	COG0545	Peptidyl-prolyl cis-trans isomerase
A7J50_RS10175	COG2200	EAL domain
A7J50_RS10185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7J50_RS10185	COG4221	oxidoreductase activity
A7J50_RS10185	COG3321	synthase
A7J50_RS10185	COG0604	alcohol dehydrogenase
A7J50_RS10195	COG3842	ATPase activity
A7J50_RS10205	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7J50_RS10230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7J50_RS10235	COG1121	(ABC) transporter
A7J50_RS10265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7J50_RS10270	COG0066	3-isopropylmalate dehydratase activity
A7J50_RS10280	COG0583	DNA-binding transcription factor activity
A7J50_RS10285	COG1301	dicarboxylic acid transport
A7J50_RS10290	COG0596	Alpha beta hydrolase
A7J50_RS10305	COG2011	ABC-type metal ion transport system permease component
A7J50_RS10325	COG3829	transcription factor binding
A7J50_RS10335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J50_RS10340	COG0431	NADPH-dependent FMN reductase
A7J50_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS10375	COG5006	permease, DMT superfamily
A7J50_RS10405	COG0583	DNA-binding transcription factor activity
A7J50_RS10415	COG0768	penicillin binding
A7J50_RS10435	COG0417	DNA replication proofreading
A7J50_RS10460	COG0728	peptidoglycan biosynthetic process
A7J50_RS10510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7J50_RS10520	COG4977	sequence-specific DNA binding
A7J50_RS10530	COG3387	PFAM Glycoside hydrolase 15-related
A7J50_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS10540	COG1595	DNA-templated transcription, initiation
A7J50_RS10550	COG4772	TonB-dependent receptor
A7J50_RS10560	COG2223	nitrite transmembrane transporter activity
A7J50_RS10565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7J50_RS10585	COG3675	Pfam Lipase (class 3)
A7J50_RS10590	COG0402	S-adenosylhomocysteine deaminase activity
A7J50_RS10595	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7J50_RS10600	COG1051	belongs to the nudix hydrolase family
A7J50_RS10610	COG0720	synthase
A7J50_RS10650	COG0840	transmembrane signaling receptor activity
A7J50_RS10655	COG2056	Na+-H+ antiporter family
A7J50_RS10665	COG0826	peptidase U32
A7J50_RS10670	COG0628	permease
A7J50_RS10690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7J50_RS10695	COG3132	Protein of unknown function, DUF480
A7J50_RS10705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A7J50_RS10715	COG0583	DNA-binding transcription factor activity
A7J50_RS10725	COG1253	flavin adenine dinucleotide binding
A7J50_RS10730	COG0709	Synthesizes selenophosphate from selenide and ATP
A7J50_RS10735	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A7J50_RS10740	COG0701	Predicted permease
A7J50_RS10750	COG0625	glutathione transferase activity
A7J50_RS10755	COG0384	phenazine biosynthesis protein PhzF
A7J50_RS10760	COG0113	porphobilinogen synthase activity
A7J50_RS10770	COG3209	COG3209 Rhs family protein
A7J50_RS10775	COG1280	lysine exporter protein (LysE YggA)
A7J50_RS10805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A7J50_RS10810	COG0583	DNA-binding transcription factor activity
A7J50_RS10820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7J50_RS10825	COG0517	IMP dehydrogenase activity
A7J50_RS10830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7J50_RS10855	COG4335	DNA alkylation repair
A7J50_RS10860	COG0174	glutamine synthetase
A7J50_RS10880	COG2814	Major facilitator Superfamily
A7J50_RS10890	COG3237	CsbD-like
A7J50_RS10915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J50_RS10935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS10950	COG1834	amidinotransferase
A7J50_RS10960	COG2192	nodulation
A7J50_RS10965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7J50_RS10980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7J50_RS10990	COG2197	response regulator
A7J50_RS10995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS10995	COG2205	protein histidine kinase activity
A7J50_RS11005	COG0656	L-ascorbic acid biosynthetic process
A7J50_RS11015	COG1024	Enoyl-CoA hydratase
A7J50_RS11020	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS11035	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7J50_RS11040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7J50_RS11045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J50_RS11065	COG2197	response regulator
A7J50_RS11070	COG0322	excinuclease ABC activity
A7J50_RS11095	COG5002	protein histidine kinase activity
A7J50_RS11100	COG0745	RESPONSE REGULATOR receiver
A7J50_RS11125	COG0642	Histidine kinase
A7J50_RS11145	COG3842	ATPase activity
A7J50_RS11175	COG0642	Histidine kinase
A7J50_RS11220	COG3284	Transcriptional regulator
A7J50_RS11225	COG3842	ATPase activity
A7J50_RS11230	COG3842	ATPase activity
A7J50_RS11240	COG0395	ABC-type sugar transport system, permease component
A7J50_RS11290	COG2814	Major facilitator Superfamily
A7J50_RS11300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7J50_RS11315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS11335	COG1116	anion transmembrane transporter activity
A7J50_RS11375	COG1741	Belongs to the pirin family
A7J50_RS11380	COG1335	isochorismatase
A7J50_RS11385	COG0583	DNA-binding transcription factor activity
A7J50_RS11390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7J50_RS11395	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS11400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J50_RS11405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS11410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J50_RS11420	COG0583	DNA-binding transcription factor activity
A7J50_RS11455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7J50_RS11460	COG2011	ABC-type metal ion transport system permease component
A7J50_RS11485	COG3706	GGDEF domain
A7J50_RS11500	COG3209	COG3209 Rhs family protein
A7J50_RS11515	COG3209	COG3209 Rhs family protein
A7J50_RS11530	COG1959	2 iron, 2 sulfur cluster binding
A7J50_RS11555	COG2207	Transcriptional regulator
A7J50_RS11585	COG0653	protein targeting
A7J50_RS11615	COG2357	RelA SpoT domain protein
A7J50_RS11620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7J50_RS11625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7J50_RS11625	COG0473	3-isopropylmalate dehydrogenase activity
A7J50_RS11630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J50_RS11670	COG1999	signal sequence binding
A7J50_RS11705	COG0693	protein deglycase activity
A7J50_RS11735	COG1304	FMN binding
A7J50_RS11745	COG3706	GGDEF domain
A7J50_RS11750	COG0494	nUDIX hydrolase
A7J50_RS11760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7J50_RS11775	COG0587	DNA-directed DNA polymerase activity
A7J50_RS11780	COG4191	Histidine kinase
A7J50_RS11780	COG0784	Response regulator, receiver
A7J50_RS11800	COG5383	Protein conserved in bacteria
A7J50_RS11830	COG0616	signal peptide processing
A7J50_RS11840	COG0583	DNA-binding transcription factor activity
A7J50_RS11850	COG2376	Dihydroxyacetone kinase
A7J50_RS11855	COG1063	alcohol dehydrogenase
A7J50_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS11865	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS11870	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS11875	COG1129	ABC transporter
A7J50_RS11880	COG0698	ribose 5-phosphate isomerase
A7J50_RS11890	COG1253	flavin adenine dinucleotide binding
A7J50_RS11910	COG0765	amino acid transport
A7J50_RS11915	COG0765	amino acid transport
A7J50_RS11940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J50_RS11945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7J50_RS11955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J50_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS11965	COG2610	gluconate transmembrane transporter activity
A7J50_RS11970	COG3829	transcription factor binding
A7J50_RS11970	COG3290	protein histidine kinase activity
A7J50_RS11975	COG4172	Belongs to the ABC transporter superfamily
A7J50_RS11980	COG4239	(ABC) transporter, permease
A7J50_RS11985	COG4174	ABC transporter (Permease)
A7J50_RS11995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7J50_RS12000	COG4172	Belongs to the ABC transporter superfamily
A7J50_RS12005	COG4239	(ABC) transporter, permease
A7J50_RS12010	COG4174	ABC transporter (Permease)
A7J50_RS12020	COG4166	transmembrane transport
A7J50_RS12025	COG1388	LysM domain
A7J50_RS12025	COG0741	lytic transglycosylase activity
A7J50_RS12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7J50_RS12040	COG0328	RNA-DNA hybrid ribonuclease activity
A7J50_RS12050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7J50_RS12060	COG0456	acetyltransferase
A7J50_RS12085	COG0431	NADPH-dependent FMN reductase
A7J50_RS12090	COG0028	Belongs to the TPP enzyme family
A7J50_RS12100	COG0789	Transcriptional regulator
A7J50_RS12115	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS12150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7J50_RS12150	COG0316	Belongs to the HesB IscA family
A7J50_RS12205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS12210	COG0577	efflux transmembrane transporter activity
A7J50_RS12210	COG1136	(ABC) transporter
A7J50_RS12225	COG1522	sequence-specific DNA binding
A7J50_RS12235	COG2814	Major facilitator Superfamily
A7J50_RS12250	COG0174	glutamine synthetase
A7J50_RS12260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS12265	COG0583	DNA-binding transcription factor activity
A7J50_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS12285	COG5002	protein histidine kinase activity
A7J50_RS12290	COG0745	RESPONSE REGULATOR receiver
A7J50_RS12320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS12325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J50_RS12335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J50_RS12345	COG3718	enzyme involved in inositol metabolism
A7J50_RS12355	COG3962	Belongs to the TPP enzyme family
A7J50_RS12360	COG0673	inositol 2-dehydrogenase activity
A7J50_RS12365	COG0673	inositol 2-dehydrogenase activity
A7J50_RS12375	COG1129	ABC transporter
A7J50_RS12380	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS12440	COG3209	COG3209 Rhs family protein
A7J50_RS12450	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7J50_RS12460	COG0456	acetyltransferase
A7J50_RS12465	COG3706	GGDEF domain
A7J50_RS12465	COG4251	negative regulation of phosphorylation
A7J50_RS12465	COG5001	Diguanylate cyclase
A7J50_RS12465	COG2203	Gaf domain
A7J50_RS12500	COG0673	inositol 2-dehydrogenase activity
A7J50_RS12510	COG2207	Transcriptional regulator
A7J50_RS12530	COG2066	Belongs to the glutaminase family
A7J50_RS12535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7J50_RS12555	COG0019	diaminopimelate decarboxylase activity
A7J50_RS12560	COG1609	Transcriptional regulator
A7J50_RS12570	COG1175	transmembrane transport
A7J50_RS12580	COG3842	ATPase activity
A7J50_RS12585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7J50_RS12625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7J50_RS12635	COG0596	Alpha beta hydrolase
A7J50_RS12640	COG0625	glutathione transferase activity
A7J50_RS12685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7J50_RS12695	COG0596	Alpha beta hydrolase
A7J50_RS12720	COG0656	L-ascorbic acid biosynthetic process
A7J50_RS12770	COG3179	chitinase
A7J50_RS12835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7J50_RS12855	COG2267	carboxylic ester hydrolase activity
A7J50_RS12860	COG3239	Fatty acid desaturase
A7J50_RS12880	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS12895	COG0183	Belongs to the thiolase family
A7J50_RS12900	COG0318	PFAM AMP-dependent synthetase and ligase
A7J50_RS12915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J50_RS12925	COG1609	Transcriptional regulator
A7J50_RS12955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J50_RS12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS12965	COG0745	RESPONSE REGULATOR receiver
A7J50_RS12970	COG2205	protein histidine kinase activity
A7J50_RS12980	COG1595	DNA-templated transcription, initiation
A7J50_RS12995	COG0730	response to heat
A7J50_RS13005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7J50_RS13015	COG0189	ligase activity
A7J50_RS13020	COG0598	Magnesium transport protein CorA
A7J50_RS13030	COG2826	transposase and inactivated derivatives, IS30 family
A7J50_RS13040	COG0024	Methionine aminopeptidase
A7J50_RS13050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7J50_RS13075	COG1070	Carbohydrate kinase
A7J50_RS13095	COG1175	transmembrane transport
A7J50_RS13140	COG1538	Outer membrane efflux protein
A7J50_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS13160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS13165	COG0348	domain, Protein
A7J50_RS13175	COG1285	pathogenesis
A7J50_RS13200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7J50_RS13205	COG3706	GGDEF domain
A7J50_RS13210	COG4191	Histidine kinase
A7J50_RS13210	COG0784	Response regulator, receiver
A7J50_RS13220	COG2814	Major facilitator Superfamily
A7J50_RS13250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7J50_RS13260	COG3397	chitin binding
A7J50_RS13265	COG3318	Belongs to the UPF0149 family
A7J50_RS13265	COG3012	SEC-C Motif Domain Protein
A7J50_RS13270	COG0038	chloride channel
A7J50_RS13275	COG1024	Enoyl-CoA hydratase
A7J50_RS13280	COG2816	NAD+ diphosphatase activity
A7J50_RS13300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7J50_RS13310	COG0667	Aldo Keto reductase
A7J50_RS13335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7J50_RS13345	COG4166	transmembrane transport
A7J50_RS13350	COG0006	proline dipeptidase activity
A7J50_RS13360	COG0583	DNA-binding transcription factor activity
A7J50_RS13375	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS13380	COG2271	Major facilitator Superfamily
A7J50_RS13385	COG4948	Mandelate Racemase Muconate Lactonizing
A7J50_RS13395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J50_RS13420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7J50_RS13425	COG1595	DNA-templated transcription, initiation
A7J50_RS13430	COG3712	iron ion homeostasis
A7J50_RS13435	COG1116	anion transmembrane transporter activity
A7J50_RS13440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J50_RS13460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7J50_RS13465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J50_RS13475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J50_RS13485	COG0583	DNA-binding transcription factor activity
A7J50_RS13500	COG0277	FAD linked oxidase domain protein
A7J50_RS13505	COG0436	Aminotransferase
A7J50_RS13510	COG0765	amino acid transport
A7J50_RS13520	COG1126	abc transporter atp-binding protein
A7J50_RS13530	COG0625	glutathione transferase activity
A7J50_RS13545	COG2271	Major facilitator Superfamily
A7J50_RS13550	COG1335	isochorismatase
A7J50_RS13555	COG3473	Maleate cis-trans isomerase
A7J50_RS13560	COG0596	Alpha beta hydrolase
A7J50_RS13565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J50_RS13570	COG2309	aminopeptidase activity
A7J50_RS13575	COG1846	Transcriptional regulator
A7J50_RS13580	COG2080	2 iron, 2 sulfur cluster binding
A7J50_RS13585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J50_RS13585	COG2010	Cytochrome c
A7J50_RS13590	COG1309	transcriptional regulator
A7J50_RS13610	COG0840	transmembrane signaling receptor activity
A7J50_RS13615	COG1968	undecaprenyl-diphosphatase activity
A7J50_RS13625	COG0154	amidase activity
A7J50_RS13640	COG2814	Major facilitator Superfamily
A7J50_RS13645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J50_RS13660	COG0488	(ABC) transporter
A7J50_RS13695	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A7J50_RS13705	COG2133	pyrroloquinoline quinone binding
A7J50_RS13720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J50_RS13730	COG2822	iron ion transport
A7J50_RS13740	COG2822	iron ion transport
A7J50_RS13745	COG0672	)-iron permease
A7J50_RS13750	COG2207	Transcriptional regulator
A7J50_RS13755	COG0076	glutamate decarboxylase activity
A7J50_RS13780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS13785	COG2814	Major facilitator Superfamily
A7J50_RS13790	COG0583	DNA-binding transcription factor activity
A7J50_RS13795	COG1335	isochorismatase
A7J50_RS13800	COG0583	DNA-binding transcription factor activity
A7J50_RS13805	COG1505	serine-type exopeptidase activity
A7J50_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS13835	COG3321	synthase
A7J50_RS13835	COG0604	alcohol dehydrogenase
A7J50_RS13845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS13860	COG0210	DNA helicase
A7J50_RS13875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS13890	COG2197	response regulator
A7J50_RS13895	COG1113	amino acid transport
A7J50_RS13940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A7J50_RS13960	COG1199	ATP-dependent helicase activity
A7J50_RS13960	COG1199	ATP-dependent helicase activity
A7J50_RS13965	COG2267	carboxylic ester hydrolase activity
A7J50_RS13975	COG0745	RESPONSE REGULATOR receiver
A7J50_RS13980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J50_RS13990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J50_RS14005	COG2308	Evidence 4 Homologs of previously reported genes of
A7J50_RS14025	COG0583	DNA-binding transcription factor activity
A7J50_RS14030	COG0667	Aldo Keto reductase
A7J50_RS14060	COG0697	spore germination
A7J50_RS14075	COG1716	ATPase activity
A7J50_RS14075	COG5001	Diguanylate cyclase
A7J50_RS14080	COG0784	Response regulator, receiver
A7J50_RS14085	COG2202	Pas domain
A7J50_RS14085	COG2205	protein histidine kinase activity
A7J50_RS14095	COG1063	alcohol dehydrogenase
A7J50_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS14130	COG1022	Amp-dependent synthetase and ligase
A7J50_RS14140	COG3038	cytochrome b561
A7J50_RS14150	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS14155	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS14160	COG1609	Transcriptional regulator
A7J50_RS14165	COG1070	Carbohydrate kinase
A7J50_RS14175	COG1522	sequence-specific DNA binding
A7J50_RS14185	COG0826	peptidase U32
A7J50_RS14215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A7J50_RS14220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7J50_RS14225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS14250	COG2197	response regulator
A7J50_RS14345	COG1942	4-Oxalocrotonate Tautomerase
A7J50_RS14360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7J50_RS14365	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A7J50_RS14375	COG0745	RESPONSE REGULATOR receiver
A7J50_RS14390	COG0784	Response regulator, receiver
A7J50_RS14390	COG4191	Histidine kinase
A7J50_RS14400	COG0302	gtp cyclohydrolase
A7J50_RS14430	COG3237	CsbD-like
A7J50_RS14435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7J50_RS14445	COG0625	glutathione transferase activity
A7J50_RS14560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7J50_RS14565	COG3459	Glycosyltransferase 36 associated
A7J50_RS14585	COG4566	intracellular signal transduction
A7J50_RS14610	COG3588	fructose-bisphosphate aldolase
A7J50_RS14615	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A7J50_RS14620	COG0149	triose-phosphate isomerase activity
A7J50_RS14625	COG4716	Myosin-crossreactive antigen
A7J50_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS14660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7J50_RS14660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7J50_RS14675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7J50_RS14690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7J50_RS14715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A7J50_RS14720	COG1349	DNA-binding transcription factor activity
A7J50_RS14730	COG0738	Major facilitator superfamily
A7J50_RS14740	COG2814	Major facilitator Superfamily
A7J50_RS14750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A7J50_RS14760	COG0463	Glycosyl transferase, family 2
A7J50_RS14765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7J50_RS14765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J50_RS14770	COG0726	polysaccharide deacetylase
A7J50_RS14775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7J50_RS14780	COG2076	Multidrug Resistance protein
A7J50_RS14785	COG2076	Multidrug Resistance protein
A7J50_RS14805	COG1024	Enoyl-CoA hydratase
A7J50_RS14810	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS14815	COG1024	Enoyl-CoA hydratase
A7J50_RS14820	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS14825	COG0183	Belongs to the thiolase family
A7J50_RS14835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J50_RS14840	COG3781	membrane
A7J50_RS14850	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A7J50_RS14865	COG2198	Histidine kinase
A7J50_RS14865	COG2205	protein histidine kinase activity
A7J50_RS14865	COG0784	Response regulator, receiver
A7J50_RS14875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7J50_RS14880	COG0784	Response regulator, receiver
A7J50_RS14880	COG2198	Histidine kinase
A7J50_RS14880	COG2205	protein histidine kinase activity
A7J50_RS14910	COG1794	racemase activity, acting on amino acids and derivatives
A7J50_RS14915	COG1247	-acetyltransferase
A7J50_RS14940	COG1929	Belongs to the glycerate kinase type-1 family
A7J50_RS14945	COG3835	regulator
A7J50_RS14950	COG2271	Major facilitator Superfamily
A7J50_RS14960	COG0583	DNA-binding transcription factor activity
A7J50_RS14965	COG0667	Aldo Keto reductase
A7J50_RS14980	COG0697	spore germination
A7J50_RS14985	COG0583	DNA-binding transcription factor activity
A7J50_RS14995	COG3121	Chaperone
A7J50_RS15000	COG3188	usher protein
A7J50_RS15005	COG3121	Chaperone
A7J50_RS15015	COG2200	EAL domain
A7J50_RS15090	COG3145	DNA-N1-methyladenine dioxygenase activity
A7J50_RS15095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7J50_RS15095	COG2169	Transcriptional regulator
A7J50_RS15130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7J50_RS15165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7J50_RS15175	COG0640	Transcriptional regulator
A7J50_RS15185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7J50_RS15190	COG0431	NADPH-dependent FMN reductase
A7J50_RS15195	COG1917	Cupin 2, conserved barrel domain protein
A7J50_RS15195	COG2207	Transcriptional regulator
A7J50_RS15255	COG2135	peptidase activity
A7J50_RS15275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7J50_RS15300	COG0531	amino acid
A7J50_RS15305	COG3938	Belongs to the proline racemase family
A7J50_RS15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS15325	COG1397	ADP-ribosylglycohydrolase
A7J50_RS15330	COG2197	response regulator
A7J50_RS15355	COG2271	Major facilitator Superfamily
A7J50_RS15430	COG2366	antibiotic biosynthetic process
A7J50_RS15445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J50_RS15450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS15455	COG1116	anion transmembrane transporter activity
A7J50_RS15455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS15475	COG0583	DNA-binding transcription factor activity
A7J50_RS15480	COG0667	Aldo Keto reductase
A7J50_RS15500	COG1238	metal cluster binding
A7J50_RS15510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J50_RS15515	COG0297	glycogen (starch) synthase activity
A7J50_RS15520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7J50_RS15525	COG1640	4-alpha-glucanotransferase
A7J50_RS15590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7J50_RS15600	COG0626	cystathionine gamma-synthase activity
A7J50_RS15605	COG1944	ATP diphosphatase activity
A7J50_RS15620	COG1309	transcriptional regulator
A7J50_RS15630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS15635	COG1335	isochorismatase
A7J50_RS15640	COG0494	nUDIX hydrolase
A7J50_RS15680	COG1846	Transcriptional regulator
A7J50_RS15680	COG0456	acetyltransferase
A7J50_RS15685	COG2271	Major facilitator Superfamily
A7J50_RS15705	COG2207	Transcriptional regulator
A7J50_RS15720	COG2207	Transcriptional regulator
A7J50_RS15725	COG2223	nitrite transmembrane transporter activity
A7J50_RS15745	COG0154	amidase activity
A7J50_RS15770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS15775	COG0697	spore germination
A7J50_RS15780	COG2353	YceI-like domain
A7J50_RS15830	COG3210	domain, Protein
A7J50_RS15860	COG3791	Glutathione-dependent formaldehyde-activating
A7J50_RS15875	COG2205	protein histidine kinase activity
A7J50_RS15880	COG0745	RESPONSE REGULATOR receiver
A7J50_RS15895	COG0589	response to stress
A7J50_RS15920	COG0814	amino acid
A7J50_RS15940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7J50_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS15960	COG2818	Glycosylase
A7J50_RS15995	COG0714	Associated with various cellular activities
A7J50_RS16030	COG0420	3'-5' exonuclease activity
A7J50_RS16050	COG2706	6-phosphogluconolactonase activity
A7J50_RS16070	COG0673	inositol 2-dehydrogenase activity
A7J50_RS16080	COG2233	PERMEase
A7J50_RS16165	COG2204	response regulator
A7J50_RS16175	COG0561	phosphatase activity
A7J50_RS16180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7J50_RS16185	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A7J50_RS16190	COG2194	sulfuric ester hydrolase activity
A7J50_RS16210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7J50_RS16225	COG0308	aminopeptidase N
A7J50_RS16235	COG3139	Protein of unknown function (DUF1315)
A7J50_RS16245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7J50_RS16250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7J50_RS16320	COG1309	transcriptional regulator
A7J50_RS16325	COG0534	Mate efflux family protein
A7J50_RS16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J50_RS16390	COG1414	Transcriptional regulator
A7J50_RS16395	COG3842	ATPase activity
A7J50_RS16400	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7J50_RS16405	COG1177	transmembrane transport
A7J50_RS16430	COG3046	protein related to deoxyribodipyrimidine photolyase
A7J50_RS16505	COG0583	DNA-binding transcription factor activity
A7J50_RS16520	COG2207	Transcriptional regulator
A7J50_RS16535	COG0475	glutathione-regulated potassium exporter activity
A7J50_RS16535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7J50_RS16565	COG0583	DNA-binding transcription factor activity
A7J50_RS16575	COG0318	PFAM AMP-dependent synthetase and ligase
A7J50_RS16590	COG1024	Enoyl-CoA hydratase
A7J50_RS16595	COG1971	Probably functions as a manganese efflux pump
A7J50_RS16600	COG1064	alcohol dehydrogenase
A7J50_RS16615	COG0604	alcohol dehydrogenase
A7J50_RS16615	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS16615	COG3321	synthase
A7J50_RS16620	COG1902	pentaerythritol trinitrate reductase activity
A7J50_RS16630	COG1309	transcriptional regulator
A7J50_RS16645	COG1968	undecaprenyl-diphosphatase activity
A7J50_RS16650	COG0625	glutathione transferase activity
A7J50_RS16675	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS16680	COG1129	ABC transporter
A7J50_RS16685	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS16695	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS16715	COG1609	Transcriptional regulator
A7J50_RS16750	COG3781	membrane
A7J50_RS16780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7J50_RS16850	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A7J50_RS16900	COG2267	carboxylic ester hydrolase activity
A7J50_RS16945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7J50_RS16950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7J50_RS16955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A7J50_RS16960	COG2835	tetraacyldisaccharide 4'-kinase activity
A7J50_RS16965	COG1663	tetraacyldisaccharide 4'-kinase activity
A7J50_RS16970	COG0848	biopolymer transport protein
A7J50_RS16975	COG0811	peptide transport
A7J50_RS16980	COG2333	competence protein COMEC
A7J50_RS16980	COG0658	competence protein
A7J50_RS17000	COG2205	protein histidine kinase activity
A7J50_RS17000	COG5002	protein histidine kinase activity
A7J50_RS17000	COG0784	Response regulator, receiver
A7J50_RS17005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7J50_RS17025	COG1393	Belongs to the ArsC family
A7J50_RS17045	COG0037	tRNA processing
A7J50_RS17055	COG3091	SprT-like family
A7J50_RS17060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J50_RS17090	COG0435	Glutathione S-transferase
A7J50_RS17095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7J50_RS17095	COG1648	precorrin-2 dehydrogenase activity
A7J50_RS17100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7J50_RS17105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7J50_RS17110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7J50_RS17115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A7J50_RS17120	COG1674	ftsk spoiiie
A7J50_RS17125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7J50_RS17130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A7J50_RS17135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7J50_RS17140	COG0542	response to heat
A7J50_RS17145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7J50_RS17150	COG1278	Cold shock
A7J50_RS17175	COG0482	sulfurtransferase activity
A7J50_RS17180	COG2915	High frequency lysogenization protein hflD homolog
A7J50_RS17190	COG2850	peptidyl-arginine hydroxylation
A7J50_RS17195	COG2153	protein acetylation
A7J50_RS17210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J50_RS17215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J50_RS17220	COG0649	NAD binding
A7J50_RS17220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J50_RS17235	COG1034	ATP synthesis coupled electron transport
A7J50_RS17240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7J50_RS17245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7J50_RS17255	COG0713	ATP synthesis coupled electron transport
A7J50_RS17270	COG1007	ATP synthesis coupled electron transport
A7J50_RS17305	COG2814	Major facilitator Superfamily
A7J50_RS17315	COG4792	protein secretion
A7J50_RS17320	COG4791	protein targeting
A7J50_RS17330	COG4790	Type iii secretion
A7J50_RS17335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7J50_RS17390	COG4964	Belongs to the GSP D family
A7J50_RS17395	COG4789	Type iii secretion
A7J50_RS17430	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS17450	COG1136	(ABC) transporter
A7J50_RS17450	COG0577	efflux transmembrane transporter activity
A7J50_RS17455	COG1136	(ABC) transporter
A7J50_RS17455	COG0577	efflux transmembrane transporter activity
A7J50_RS17465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS17470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J50_RS17530	COG2111	Na H antiporter
A7J50_RS17530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7J50_RS17535	COG1006	Multisubunit Na H antiporter MnhC subunit
A7J50_RS17540	COG0651	ATP synthesis coupled electron transport
A7J50_RS17545	COG1863	multisubunit Na H antiporter MnhE subunit
A7J50_RS17550	COG2212	antiporter activity
A7J50_RS17555	COG1320	monovalent cation:proton antiporter activity
A7J50_RS17585	COG0215	cysteine-tRNA ligase activity
A7J50_RS17590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7J50_RS17600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7J50_RS17605	COG2814	Major facilitator Superfamily
A7J50_RS17610	COG1566	PFAM secretion protein HlyD family protein
A7J50_RS17620	COG1846	Transcriptional regulator
A7J50_RS17625	COG2911	Protein conserved in bacteria
A7J50_RS17630	COG0729	surface antigen
A7J50_RS17640	COG0708	Exodeoxyribonuclease III
A7J50_RS17645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7J50_RS17650	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS17660	COG0789	Transcriptional regulator
A7J50_RS17675	COG0318	PFAM AMP-dependent synthetase and ligase
A7J50_RS17680	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS17685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J50_RS17690	COG1024	Enoyl-CoA hydratase
A7J50_RS17710	COG2866	Carboxypeptidase
A7J50_RS17715	COG3038	cytochrome b561
A7J50_RS17720	COG0753	catalase activity
A7J50_RS17770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7J50_RS17780	COG0217	transcriptional regulatory protein
A7J50_RS17785	COG0583	DNA-binding transcription factor activity
A7J50_RS17790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7J50_RS17795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J50_RS17800	COG3038	cytochrome b561
A7J50_RS17810	COG1902	pentaerythritol trinitrate reductase activity
A7J50_RS17810	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J50_RS17830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7J50_RS17835	COG0776	regulation of translation
A7J50_RS17840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7J50_RS17845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7J50_RS17850	COG0740	serine-type endopeptidase activity
A7J50_RS17855	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7J50_RS17880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7J50_RS17885	COG1686	Belongs to the peptidase S11 family
A7J50_RS17905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS17925	COG1953	Uracil, thiamine, allantoin
A7J50_RS17935	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7J50_RS17935	COG0493	'glutamate synthase
A7J50_RS17945	COG1309	transcriptional regulator
A7J50_RS17965	COG1276	copper resistance
A7J50_RS17975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J50_RS18010	COG0640	Transcriptional regulator
A7J50_RS18030	COG1522	sequence-specific DNA binding
A7J50_RS18035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A7J50_RS18040	COG0022	dehydrogenase e1 component
A7J50_RS18050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7J50_RS18055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7J50_RS18060	COG0456	acetyltransferase
A7J50_RS18070	COG2423	ornithine cyclodeaminase activity
A7J50_RS18080	COG4215	(ABC) transporter
A7J50_RS18125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS18130	COG0577	efflux transmembrane transporter activity
A7J50_RS18130	COG1136	(ABC) transporter
A7J50_RS18140	COG0596	Alpha beta hydrolase
A7J50_RS18145	COG2186	Transcriptional regulator
A7J50_RS18180	COG0154	amidase activity
A7J50_RS18200	COG1609	Transcriptional regulator
A7J50_RS18205	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS18210	COG1070	Carbohydrate kinase
A7J50_RS18215	COG1063	alcohol dehydrogenase
A7J50_RS18220	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS18230	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS18270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7J50_RS18275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7J50_RS18330	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7J50_RS18340	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS18345	COG3384	dioxygenase
A7J50_RS18355	COG2271	Major facilitator Superfamily
A7J50_RS18360	COG3971	2-oxopent-4-enoate hydratase activity
A7J50_RS18370	COG1846	Transcriptional regulator
A7J50_RS18375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS18410	COG0531	amino acid
A7J50_RS18420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7J50_RS18425	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS18430	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS18445	COG0583	DNA-binding transcription factor activity
A7J50_RS18455	COG0625	glutathione transferase activity
A7J50_RS18460	COG0583	DNA-binding transcription factor activity
A7J50_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS18470	COG1063	alcohol dehydrogenase
A7J50_RS18475	COG0390	transport system, permease component
A7J50_RS18480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7J50_RS18485	COG0667	Aldo Keto reductase
A7J50_RS18500	COG3121	Chaperone
A7J50_RS18510	COG2205	protein histidine kinase activity
A7J50_RS18510	COG0784	Response regulator, receiver
A7J50_RS18515	COG2203	Gaf domain
A7J50_RS18515	COG2200	EAL domain
A7J50_RS18515	COG2199	diguanylate cyclase activity
A7J50_RS18520	COG0784	Response regulator, receiver
A7J50_RS18520	COG2205	protein histidine kinase activity
A7J50_RS18525	COG2197	response regulator
A7J50_RS18535	COG3121	Chaperone
A7J50_RS18590	COG1231	oxidoreductase activity
A7J50_RS18595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS18600	COG1126	abc transporter atp-binding protein
A7J50_RS18615	COG1120	ATPase activity
A7J50_RS18620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J50_RS18625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J50_RS18630	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7J50_RS18635	COG4774	siderophore transport
A7J50_RS18655	COG2963	transposase activity
A7J50_RS18660	COG2801	Transposase and inactivated derivatives
A7J50_RS18670	COG2801	Transposase and inactivated derivatives
A7J50_RS18715	COG3179	chitinase
A7J50_RS18915	COG1484	DNA-dependent DNA replication
A7J50_RS19075	COG0776	regulation of translation
A7J50_RS19080	COG0072	phenylalanine-tRNA ligase activity
A7J50_RS19085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7J50_RS19090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7J50_RS19095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7J50_RS19100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7J50_RS19105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7J50_RS19115	COG1278	Cold shock
A7J50_RS19140	COG1869	D-ribose catabolic process
A7J50_RS19145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J50_RS19150	COG1609	Transcriptional regulator
A7J50_RS19155	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS19160	COG1129	ABC transporter
A7J50_RS19165	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS19190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7J50_RS19205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J50_RS19265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS19300	COG1286	toxin biosynthetic process
A7J50_RS19305	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7J50_RS19310	COG0285	dihydrofolate synthase activity
A7J50_RS19315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7J50_RS19320	COG0135	phosphoribosylanthranilate isomerase activity
A7J50_RS19345	COG0473	3-isopropylmalate dehydrogenase activity
A7J50_RS19350	COG2226	methyltransferase
A7J50_RS19355	COG0066	3-isopropylmalate dehydratase activity
A7J50_RS19360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7J50_RS19375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7J50_RS19385	COG0596	Alpha beta hydrolase
A7J50_RS19415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7J50_RS19420	COG0556	nucleotide-excision repair
A7J50_RS19435	COG0583	DNA-binding transcription factor activity
A7J50_RS19440	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS19445	COG5002	protein histidine kinase activity
A7J50_RS19450	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A7J50_RS19460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7J50_RS19465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J50_RS19470	COG1120	ATPase activity
A7J50_RS19490	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A7J50_RS19520	COG0840	transmembrane signaling receptor activity
A7J50_RS19535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7J50_RS19545	COG1280	lysine exporter protein (LysE YggA)
A7J50_RS19560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS19570	COG0840	transmembrane signaling receptor activity
A7J50_RS19580	COG0124	histidyl-tRNA synthetase
A7J50_RS19585	COG2384	SAM-dependent methyltransferase
A7J50_RS19590	COG2186	Transcriptional regulator
A7J50_RS19615	COG3657	addiction module killer protein
A7J50_RS19620	COG4521	taurine ABC transporter
A7J50_RS19650	COG5285	phytanoyl-CoA dioxygenase
A7J50_RS19655	COG1126	abc transporter atp-binding protein
A7J50_RS19660	COG0583	DNA-binding transcription factor activity
A7J50_RS19670	COG0604	alcohol dehydrogenase
A7J50_RS19670	COG3321	synthase
A7J50_RS19670	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS19675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7J50_RS19720	COG3706	GGDEF domain
A7J50_RS19720	COG4251	negative regulation of phosphorylation
A7J50_RS19720	COG5001	Diguanylate cyclase
A7J50_RS19720	COG2203	Gaf domain
A7J50_RS19730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7J50_RS19745	COG0402	S-adenosylhomocysteine deaminase activity
A7J50_RS19755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A7J50_RS19765	COG0583	DNA-binding transcription factor activity
A7J50_RS19795	COG2391	methyltransferase activity
A7J50_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS19835	COG0583	DNA-binding transcription factor activity
A7J50_RS19840	COG2814	Major facilitator Superfamily
A7J50_RS19845	COG1309	transcriptional regulator
A7J50_RS19885	COG1309	transcriptional regulator
A7J50_RS19895	COG0583	DNA-binding transcription factor activity
A7J50_RS19900	COG1304	FMN binding
A7J50_RS19915	COG5001	Diguanylate cyclase
A7J50_RS19915	COG5002	protein histidine kinase activity
A7J50_RS19930	COG1054	Belongs to the UPF0176 family
A7J50_RS19935	COG0271	Belongs to the BolA IbaG family
A7J50_RS19945	COG0114	fumarate hydratase activity
A7J50_RS19955	COG0697	spore germination
A7J50_RS19960	COG0183	Belongs to the thiolase family
A7J50_RS19965	COG2326	polyphosphate kinase activity
A7J50_RS19975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7J50_RS19975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS19980	COG0367	asparagine synthase
A7J50_RS19985	COG0189	ligase activity
A7J50_RS19985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7J50_RS19995	COG3089	Belongs to the UPF0270 family
A7J50_RS20000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7J50_RS20010	COG1368	sulfuric ester hydrolase activity
A7J50_RS20030	COG0318	PFAM AMP-dependent synthetase and ligase
A7J50_RS20045	COG2197	response regulator
A7J50_RS20050	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A7J50_RS20060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7J50_RS20065	COG1073	alpha beta
A7J50_RS20090	COG2840	Smr protein MutS2
A7J50_RS20110	COG0302	gtp cyclohydrolase
A7J50_RS20130	COG2851	Citrate transporter
A7J50_RS20135	COG0583	DNA-binding transcription factor activity
A7J50_RS20140	COG0625	glutathione transferase activity
A7J50_RS20145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS20155	COG2252	PERMEase
A7J50_RS20185	COG4266	Belongs to the allantoicase family
A7J50_RS20190	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A7J50_RS20200	COG2233	PERMEase
A7J50_RS20215	COG1560	Kdo2-lipid A biosynthetic process
A7J50_RS20220	COG0850	regulation of cytokinetic process
A7J50_RS20225	COG2894	cell division
A7J50_RS20230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A7J50_RS20235	COG0564	pseudouridine synthase activity
A7J50_RS20240	COG1362	aminopeptidase activity
A7J50_RS20245	COG0668	transmembrane transport
A7J50_RS20250	COG1473	amidohydrolase
A7J50_RS20265	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7J50_RS20285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7J50_RS20295	COG3469	chitinase activity
A7J50_RS20300	COG3397	chitin binding
A7J50_RS20325	COG1309	transcriptional regulator
A7J50_RS20340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7J50_RS20345	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS20350	COG1024	Enoyl-CoA hydratase
A7J50_RS20365	COG3123	guanosine phosphorylase activity
A7J50_RS20385	COG3851	Histidine kinase
A7J50_RS20390	COG2197	response regulator
A7J50_RS20395	COG1597	lipid kinase activity
A7J50_RS20420	COG0835	chemotaxis
A7J50_RS20430	COG1192	Involved in chromosome partitioning
A7J50_RS20435	COG1360	Flagellar Motor Protein
A7J50_RS20440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A7J50_RS20445	COG2201	protein-glutamate methylesterase activity
A7J50_RS20450	COG0784	Response regulator, receiver
A7J50_RS20450	COG2198	Histidine kinase
A7J50_RS20450	COG0643	Histidine kinase
A7J50_RS20455	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A7J50_RS20490	COG1278	Cold shock
A7J50_RS20500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7J50_RS20585	COG1677	Flagellar hook-basal body complex protein FliE
A7J50_RS20640	COG1256	bacterial-type flagellum assembly
A7J50_RS20650	COG1706	bacterial-type flagellum-dependent cell motility
A7J50_RS20655	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A7J50_RS20665	COG4787	bacterial-type flagellum-dependent cell motility
A7J50_RS20680	COG2154	pterin-4-alpha-carbinolamine dehydratase
A7J50_RS20695	COG2207	Transcriptional regulator
A7J50_RS20710	COG1752	Esterase of the alpha-beta hydrolase superfamily
A7J50_RS20715	COG1846	Transcriptional regulator
A7J50_RS20720	COG0514	ATP-dependent DNA helicase (RecQ)
A7J50_RS20730	COG2832	Protein of unknown function (DUF454)
A7J50_RS20735	COG2205	protein histidine kinase activity
A7J50_RS20735	COG0784	Response regulator, receiver
A7J50_RS20780	COG1846	Transcriptional regulator
A7J50_RS20785	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A7J50_RS20790	COG0406	alpha-ribazole phosphatase activity
A7J50_RS20795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7J50_RS20805	COG1492	cobalamin metabolic process
A7J50_RS20820	COG0778	Nitroreductase
A7J50_RS20825	COG1797	cobyrinic acid a,c-diamide synthase activity
A7J50_RS20840	COG0791	NLP P60 protein
A7J50_RS20845	COG0791	NLP P60 protein
A7J50_RS20850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7J50_RS20855	COG0628	permease
A7J50_RS20865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7J50_RS20870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7J50_RS20885	COG4264	IucA IucC family
A7J50_RS20890	COG2814	Major facilitator Superfamily
A7J50_RS20900	COG3122	Protein conserved in bacteria
A7J50_RS20905	COG3956	TIGRFAM MazG family protein
A7J50_RS20910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7J50_RS20915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7J50_RS20950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7J50_RS20960	COG0583	DNA-binding transcription factor activity
A7J50_RS20970	COG1953	Uracil, thiamine, allantoin
A7J50_RS20980	COG2996	Protein conserved in bacteria
A7J50_RS21010	COG0513	Belongs to the DEAD box helicase family
A7J50_RS21015	COG0668	transmembrane transport
A7J50_RS21025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7J50_RS21050	COG1132	(ABC) transporter
A7J50_RS21060	COG2188	Transcriptional regulator
A7J50_RS21070	COG1595	DNA-templated transcription, initiation
A7J50_RS21080	COG1643	Atp-dependent helicase
A7J50_RS21085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A7J50_RS21090	COG0840	transmembrane signaling receptor activity
A7J50_RS21105	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A7J50_RS21115	COG0175	sulfate reduction
A7J50_RS21130	COG0463	Glycosyl transferase, family 2
A7J50_RS21145	COG1215	transferase activity, transferring glycosyl groups
A7J50_RS21180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A7J50_RS21215	COG0840	transmembrane signaling receptor activity
A7J50_RS21225	COG3278	Belongs to the heme-copper respiratory oxidase family
A7J50_RS21240	COG2010	Cytochrome c
A7J50_RS21245	COG3278	Belongs to the heme-copper respiratory oxidase family
A7J50_RS21260	COG2010	Cytochrome c
A7J50_RS21265	COG0348	domain, Protein
A7J50_RS21300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7J50_RS21305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7J50_RS21310	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS21315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7J50_RS21320	COG2130	NADP-dependent
A7J50_RS21325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7J50_RS21330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7J50_RS21350	COG0583	DNA-binding transcription factor activity
A7J50_RS21390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7J50_RS21395	COG3115	cell septum assembly
A7J50_RS21415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J50_RS21425	COG0402	S-adenosylhomocysteine deaminase activity
A7J50_RS21430	COG1802	Transcriptional regulator
A7J50_RS21435	COG3135	benzoate transporter
A7J50_RS21440	COG3171	Protein conserved in bacteria
A7J50_RS21450	COG3706	GGDEF domain
A7J50_RS21455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7J50_RS21455	COG0116	Belongs to the methyltransferase superfamily
A7J50_RS21460	COG0167	dihydroorotate dehydrogenase activity
A7J50_RS21480	COG1116	anion transmembrane transporter activity
A7J50_RS21480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS21485	COG3707	response regulator
A7J50_RS21490	COG2223	nitrite transmembrane transporter activity
A7J50_RS21495	COG0515	serine threonine protein kinase
A7J50_RS21495	COG2815	serine threonine protein kinase
A7J50_RS21500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7J50_RS21505	COG2146	nitrite reductase [NAD(P)H] activity
A7J50_RS21510	COG0243	molybdopterin cofactor binding
A7J50_RS21515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7J50_RS21520	COG2885	chlorophyll binding
A7J50_RS21520	COG3047	cAMP biosynthetic process
A7J50_RS21545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7J50_RS21560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A7J50_RS21565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS21580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7J50_RS21585	COG1045	serine acetyltransferase
A7J50_RS21590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7J50_RS21605	COG1116	anion transmembrane transporter activity
A7J50_RS21625	COG0372	Belongs to the citrate synthase family
A7J50_RS21635	COG1802	Transcriptional regulator
A7J50_RS21640	COG0189	ligase activity
A7J50_RS21640	COG4067	protein conserved in archaea
A7J50_RS21650	COG0189	ligase activity
A7J50_RS21670	COG0560	Phosphoserine phosphatase
A7J50_RS21680	COG1953	Uracil, thiamine, allantoin
A7J50_RS21690	COG0583	DNA-binding transcription factor activity
A7J50_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS21700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7J50_RS21790	COG3121	Chaperone
A7J50_RS21800	COG2205	protein histidine kinase activity
A7J50_RS21800	COG0784	Response regulator, receiver
A7J50_RS21800	COG5002	protein histidine kinase activity
A7J50_RS21810	COG2197	response regulator
A7J50_RS21820	COG3706	GGDEF domain
A7J50_RS21820	COG2203	Gaf domain
A7J50_RS21820	COG4251	negative regulation of phosphorylation
A7J50_RS21820	COG5001	Diguanylate cyclase
A7J50_RS21840	COG4695	Portal protein
A7J50_RS22050	COG0582	viral genome integration into host DNA
A7J50_RS22070	COG0598	Magnesium transport protein CorA
A7J50_RS22075	COG0519	Catalyzes the synthesis of GMP from XMP
A7J50_RS22080	COG1024	Enoyl-CoA hydratase
A7J50_RS22080	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J50_RS22085	COG0183	Belongs to the thiolase family
A7J50_RS22095	COG1305	Transglutaminase-like
A7J50_RS22105	COG2308	Evidence 4 Homologs of previously reported genes of
A7J50_RS22135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS22140	COG2885	chlorophyll binding
A7J50_RS22140	COG3047	cAMP biosynthetic process
A7J50_RS22170	COG2207	Transcriptional regulator
A7J50_RS22175	COG1064	alcohol dehydrogenase
A7J50_RS22180	COG1414	Transcriptional regulator
A7J50_RS22185	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7J50_RS22190	COG1129	ABC transporter
A7J50_RS22195	COG1879	ABC-type sugar transport system periplasmic component
A7J50_RS22200	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS22230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7J50_RS22240	COG1397	ADP-ribosylglycohydrolase
A7J50_RS22245	COG2188	Transcriptional regulator
A7J50_RS22260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7J50_RS22270	COG0084	hydrolase, TatD family'
A7J50_RS22280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7J50_RS22285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7J50_RS22295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7J50_RS22300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7J50_RS22315	COG0416	fatty acid biosynthetic process
A7J50_RS22320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7J50_RS22330	COG0424	maF-like protein
A7J50_RS22335	COG0616	signal peptide processing
A7J50_RS22335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7J50_RS22340	COG0546	phosphoglycolate phosphatase activity
A7J50_RS22350	COG1530	ribonuclease E activity
A7J50_RS22360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7J50_RS22360	COG3608	succinylglutamate desuccinylase aspartoacylase
A7J50_RS22365	COG1301	dicarboxylic acid transport
A7J50_RS22370	COG1917	Cupin 2, conserved barrel domain protein
A7J50_RS22370	COG4977	sequence-specific DNA binding
A7J50_RS22390	COG2977	Belongs to the P-Pant transferase superfamily
A7J50_RS22395	COG2205	protein histidine kinase activity
A7J50_RS22400	COG0745	RESPONSE REGULATOR receiver
A7J50_RS22420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7J50_RS22425	COG1558	bacterial-type flagellum-dependent cell motility
A7J50_RS22430	COG1815	bacterial-type flagellum-dependent cell motility
A7J50_RS22440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7J50_RS22445	COG0784	Response regulator, receiver
A7J50_RS22445	COG0835	chemotaxis
A7J50_RS22465	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A7J50_RS22470	COG0477	Major facilitator Superfamily
A7J50_RS22495	COG2239	Acts as a magnesium transporter
A7J50_RS22515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7J50_RS22520	COG0527	aspartate kinase activity
A7J50_RS22525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7J50_RS22530	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A7J50_RS22535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7J50_RS22540	COG2988	succinylglutamate desuccinylase activity
A7J50_RS22550	COG3724	N-succinylarginine dihydrolase activity
A7J50_RS22555	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS22570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J50_RS22600	COG4215	(ABC) transporter
A7J50_RS22605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS22610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J50_RS22620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7J50_RS22650	COG0165	Argininosuccinate lyase
A7J50_RS22655	COG0765	amino acid transport
A7J50_RS22670	COG2814	Major facilitator Superfamily
A7J50_RS22685	COG0563	adenylate kinase activity
A7J50_RS22705	COG3706	GGDEF domain
A7J50_RS22720	COG0583	DNA-binding transcription factor activity
A7J50_RS22725	COG0504	CTP synthase activity
A7J50_RS22730	COG2329	Antibiotic biosynthesis monooxygenase
A7J50_RS22740	COG0584	glycerophosphoryl diester phosphodiesterase
A7J50_RS22760	COG0306	phosphate transporter
A7J50_RS22765	COG1984	allophanate hydrolase subunit 2
A7J50_RS22775	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7J50_RS22785	COG0583	DNA-binding transcription factor activity
A7J50_RS22790	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS22805	COG0583	DNA-binding transcription factor activity
A7J50_RS22810	COG4941	Belongs to the sigma-70 factor family
A7J50_RS22820	COG3795	YCII-related domain
A7J50_RS22845	COG0436	Aminotransferase
A7J50_RS22855	COG3265	gluconokinase activity
A7J50_RS22860	COG1609	Transcriptional regulator
A7J50_RS22875	COG2271	Major facilitator Superfamily
A7J50_RS22890	COG0583	DNA-binding transcription factor activity
A7J50_RS22900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS22910	COG1595	DNA-templated transcription, initiation
A7J50_RS22935	COG0242	peptide deformylase activity
A7J50_RS22940	COG1295	ribonuclease BN
A7J50_RS22960	COG0318	PFAM AMP-dependent synthetase and ligase
A7J50_RS22970	COG2030	dehydratase
A7J50_RS22980	COG3530	Putative quorum-sensing-regulated virulence factor
A7J50_RS22985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7J50_RS22990	COG0800	Aldolase
A7J50_RS23005	COG1737	Transcriptional regulator
A7J50_RS23010	COG0676	glucose-6-phosphate 1-epimerase activity
A7J50_RS23020	COG3842	ATPase activity
A7J50_RS23025	COG0395	ABC-type sugar transport system, permease component
A7J50_RS23030	COG1175	transmembrane transport
A7J50_RS23035	COG1653	transport
A7J50_RS23040	COG2942	2-epimerase
A7J50_RS23050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7J50_RS23055	COG0583	DNA-binding transcription factor activity
A7J50_RS23070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7J50_RS23085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7J50_RS23120	COG1113	amino acid transport
A7J50_RS23140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7J50_RS23150	COG0009	L-threonylcarbamoyladenylate synthase
A7J50_RS23160	COG2917	probably involved in intracellular septation
A7J50_RS23165	COG2350	Protein conserved in bacteria
A7J50_RS23175	COG0745	RESPONSE REGULATOR receiver
A7J50_RS23185	COG0642	Histidine kinase
A7J50_RS23190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J50_RS23235	COG0509	glycine decarboxylation via glycine cleavage system
A7J50_RS23240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7J50_RS23240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7J50_RS23245	COG1760	l-serine dehydratase
A7J50_RS23250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7J50_RS23255	COG1278	Cold shock
A7J50_RS23265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7J50_RS23295	COG0573	inorganic phosphate transmembrane transporter activity
A7J50_RS23305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7J50_RS23320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7J50_RS23325	COG0602	queuosine metabolic process
A7J50_RS23330	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A7J50_RS23335	COG2885	chlorophyll binding
A7J50_RS23340	COG0823	Involved in the tonB-independent uptake of proteins
A7J50_RS23360	COG0824	Thioesterase
A7J50_RS23365	COG2255	four-way junction helicase activity
A7J50_RS23370	COG0632	four-way junction helicase activity
A7J50_RS23375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7J50_RS23380	COG0217	transcriptional regulatory protein
A7J50_RS23385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7J50_RS23400	COG0783	Belongs to the Dps family
A7J50_RS23410	COG2900	Belongs to the SlyX family
A7J50_RS23425	COG0668	transmembrane transport
A7J50_RS23430	COG1666	GTP binding
A7J50_RS23440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS23440	COG4191	Histidine kinase
A7J50_RS23445	COG2096	Adenosyltransferase
A7J50_RS23455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7J50_RS23460	COG0653	protein targeting
A7J50_RS23470	COG0433	COG0433 Predicted ATPase
A7J50_RS23480	COG0788	formyltetrahydrofolate deformylase activity
A7J50_RS23490	COG2925	Exonuclease
A7J50_RS23515	COG0714	Associated with various cellular activities
A7J50_RS23535	COG0469	pyruvate kinase activity
A7J50_RS23540	COG1024	Enoyl-CoA hydratase
A7J50_RS23545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7J50_RS23555	COG4191	Histidine kinase
A7J50_RS23565	COG0477	Major facilitator Superfamily
A7J50_RS23590	COG2207	Transcriptional regulator
A7J50_RS23625	COG3712	iron ion homeostasis
A7J50_RS23630	COG4771	TonB-dependent receptor
A7J50_RS23640	COG2832	Protein of unknown function (DUF454)
A7J50_RS23645	COG0840	transmembrane signaling receptor activity
A7J50_RS23675	COG1696	Membrane protein involved in D-alanine export
A7J50_RS23685	COG3642	lipopolysaccharide core region biosynthetic process
A7J50_RS23705	COG1368	sulfuric ester hydrolase activity
A7J50_RS23710	COG0745	RESPONSE REGULATOR receiver
A7J50_RS23715	COG2205	protein histidine kinase activity
A7J50_RS23725	COG0459	protein refolding
A7J50_RS23730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7J50_RS23755	COG2211	Major facilitator Superfamily
A7J50_RS23760	COG0442	prolyl-tRNA aminoacylation
A7J50_RS23770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7J50_RS23805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7J50_RS23835	COG4974	Belongs to the 'phage' integrase family
A7J50_RS23840	COG1607	acyl-coa hydrolase
A7J50_RS23845	COG0335	large ribosomal subunit rRNA binding
A7J50_RS23850	COG0336	Belongs to the RNA methyltransferase TrmD family
A7J50_RS23855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7J50_RS23860	COG0228	four-way junction DNA binding
A7J50_RS23865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7J50_RS23875	COG4536	flavin adenine dinucleotide binding
A7J50_RS23880	COG0477	Major facilitator Superfamily
A7J50_RS23885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7J50_RS23905	COG0494	nUDIX hydrolase
A7J50_RS23920	COG2188	Transcriptional regulator
A7J50_RS23925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7J50_RS23930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7J50_RS23935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7J50_RS23935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J50_RS23940	COG2190	(PTS) system
A7J50_RS23940	COG1263	PTS System
A7J50_RS23940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J50_RS23965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7J50_RS23970	COG0047	phosphoribosylformylglycinamidine synthase activity
A7J50_RS23970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7J50_RS23975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7J50_RS23985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7J50_RS23985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7J50_RS23990	COG4580	involved in the transport of maltose and maltodextrins
A7J50_RS23995	COG0366	Alpha amylase catalytic
A7J50_RS24000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7J50_RS24000	COG1263	PTS System
A7J50_RS24005	COG2188	Transcriptional regulator
A7J50_RS24015	COG0519	Catalyzes the synthesis of GMP from XMP
A7J50_RS24015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7J50_RS24035	COG0583	DNA-binding transcription factor activity
A7J50_RS24040	COG1570	exodeoxyribonuclease VII activity
A7J50_RS24045	COG0739	heme binding
A7J50_RS24050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7J50_RS24055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J50_RS24060	COG0436	Aminotransferase
A7J50_RS24065	COG1160	GTP binding
A7J50_RS24080	COG0124	histidyl-tRNA synthetase
A7J50_RS24085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7J50_RS24090	COG1426	Protein conserved in bacteria
A7J50_RS24100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7J50_RS24105	COG0105	UTP biosynthetic process
A7J50_RS24115	COG0633	Ferredoxin
A7J50_RS24120	COG0443	Heat shock 70 kDa protein
A7J50_RS24125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7J50_RS24130	COG0316	Belongs to the HesB IscA family
A7J50_RS24140	COG1104	cysteine desulfurase activity
A7J50_RS24165	COG3134	Outer membrane lipoprotein
A7J50_RS24180	COG1862	Preprotein translocase
A7J50_RS24185	COG0343	queuine tRNA-ribosyltransferase activity
A7J50_RS24190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7J50_RS24215	COG1280	lysine exporter protein (LysE YggA)
A7J50_RS24300	COG4251	negative regulation of phosphorylation
A7J50_RS24310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS24315	COG0583	DNA-binding transcription factor activity
A7J50_RS24320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7J50_RS24335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7J50_RS24340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7J50_RS24345	COG0109	protoheme IX farnesyltransferase activity
A7J50_RS24360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7J50_RS24365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7J50_RS24370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A7J50_RS24375	COG1017	nitric oxide dioxygenase activity
A7J50_RS24375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7J50_RS24390	COG3708	Transcriptional regulator
A7J50_RS24390	COG2207	Transcriptional regulator
A7J50_RS24395	COG2197	response regulator
A7J50_RS24410	COG1028	Short-chain dehydrogenase reductase Sdr
A7J50_RS24415	COG0596	Alpha beta hydrolase
A7J50_RS24425	COG1346	cytolysis
A7J50_RS24435	COG0583	DNA-binding transcription factor activity
A7J50_RS24445	COG1366	Belongs to the anti-sigma-factor antagonist family
A7J50_RS24475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7J50_RS24490	COG0492	ferredoxin-NADP+ reductase activity
A7J50_RS24495	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A7J50_RS24510	COG0386	Belongs to the glutathione peroxidase family
A7J50_RS24515	COG3045	CreA protein
A7J50_RS24520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7J50_RS24525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7J50_RS24530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7J50_RS24535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7J50_RS24540	COG0142	geranyltranstransferase activity
A7J50_RS24545	COG2824	Alkylphosphonate utilization operon protein PhnA
A7J50_RS24550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7J50_RS24555	COG0545	Peptidyl-prolyl cis-trans isomerase
A7J50_RS24560	COG0840	transmembrane signaling receptor activity
A7J50_RS24570	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A7J50_RS24580	COG2610	gluconate transmembrane transporter activity
A7J50_RS24590	COG0659	secondary active sulfate transmembrane transporter activity
A7J50_RS24600	COG0583	DNA-binding transcription factor activity
A7J50_RS24605	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7J50_RS24615	COG0583	DNA-binding transcription factor activity
A7J50_RS24620	COG1113	amino acid transport
A7J50_RS24630	COG1522	sequence-specific DNA binding
A7J50_RS24635	COG3485	protocatechuate 3,4-dioxygenase
A7J50_RS24640	COG4829	muconolactone delta-isomerase
A7J50_RS24645	COG4948	Mandelate Racemase Muconate Lactonizing
A7J50_RS24660	COG4638	Rieske (2fe-2S)
A7J50_RS24665	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A7J50_RS24670	COG0543	2 iron, 2 sulfur cluster binding
A7J50_RS24670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7J50_RS24675	COG1113	amino acid transport
A7J50_RS24680	COG3483	tryptophan 2,3-dioxygenase activity
A7J50_RS24685	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A7J50_RS24715	COG0583	DNA-binding transcription factor activity
A7J50_RS24755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7J50_RS24760	COG1074	ATP-dependent DNA helicase activity
A7J50_RS24765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7J50_RS24795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A7J50_RS24800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7J50_RS24805	COG1183	phosphatidylcholine synthase activity
A7J50_RS24810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7J50_RS24820	COG0028	Belongs to the TPP enzyme family
A7J50_RS24825	COG3098	single-species biofilm formation
A7J50_RS24835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J50_RS24855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7J50_RS24860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7J50_RS24865	COG4558	Periplasmic binding protein
A7J50_RS24875	COG1489	DNA binding
A7J50_RS24880	COG0436	Aminotransferase
A7J50_RS24890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7J50_RS24895	COG4191	Histidine kinase
A7J50_RS24915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7J50_RS24920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7J50_RS24925	COG0166	Belongs to the GPI family
A7J50_RS24930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7J50_RS24940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7J50_RS24950	COG2823	Periplasmic or secreted lipoprotein
A7J50_RS24955	COG1185	polyribonucleotide nucleotidyltransferase activity
A7J50_RS24960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7J50_RS24965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7J50_RS24970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7J50_RS24975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7J50_RS24980	COG0195	Participates in both transcription termination and antitermination
A7J50_RS24985	COG0779	Required for maturation of 30S ribosomal subunits
A7J50_RS25000	COG0149	triose-phosphate isomerase activity
A7J50_RS25005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J50_RS25010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7J50_RS25020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A7J50_RS25035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7J50_RS25040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7J50_RS25045	COG0505	Belongs to the CarA family
A7J50_RS25050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7J50_RS25055	COG0484	heat shock protein binding
A7J50_RS25060	COG0443	Heat shock 70 kDa protein
A7J50_RS25065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7J50_RS25070	COG0497	DNA recombination
A7J50_RS25075	COG0735	belongs to the Fur family
A7J50_RS25080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7J50_RS25085	COG2914	Belongs to the UPF0125 (RnfH) family
A7J50_RS25095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7J50_RS25100	COG2186	Transcriptional regulator
A7J50_RS25105	COG1620	l-lactate permease
A7J50_RS25125	COG0582	viral genome integration into host DNA
A7J50_RS25135	COG1074	ATP-dependent DNA helicase activity
A7J50_RS25150	COG4983	Phage plasmid primase, P4 family domain protein
A7J50_RS25200	COG2862	Uncharacterized protein family, UPF0114
A7J50_RS25215	COG1067	ATP-dependent peptidase activity
A7J50_RS25245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7J50_RS25255	COG0488	(ABC) transporter
A7J50_RS25265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7J50_RS25270	COG0523	cobalamin synthesis protein
A7J50_RS25275	COG2879	small protein
A7J50_RS25280	COG1966	Carbon starvation protein
A7J50_RS25310	COG1970	mechanosensitive ion channel activity
A7J50_RS25320	COG2197	response regulator
A7J50_RS25325	COG2813	Specifically methylates the guanine in position
A7J50_RS25330	COG1294	oxidase, subunit
A7J50_RS25335	COG1271	oxidase subunit
A7J50_RS25345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7J50_RS25350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A7J50_RS25355	COG2080	2 iron, 2 sulfur cluster binding
A7J50_RS25365	COG2252	PERMEase
A7J50_RS25370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7J50_RS25385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7J50_RS25390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7J50_RS25395	COG1309	transcriptional regulator
A7J50_RS25400	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A7J50_RS25400	COG1082	Xylose isomerase domain protein TIM barrel
A7J50_RS25405	COG0477	Major facilitator Superfamily
A7J50_RS25420	COG2321	neutral zinc metallopeptidase
A7J50_RS25435	COG1946	Acyl-CoA thioesterase
A7J50_RS25445	COG0123	including yeast histone deacetylase and acetoin utilization protein
A7J50_RS25455	COG0513	Belongs to the DEAD box helicase family
A7J50_RS25460	COG0697	spore germination
A7J50_RS25465	COG1522	sequence-specific DNA binding
A7J50_RS25485	COG1199	ATP-dependent helicase activity
A7J50_RS25485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7J50_RS25495	COG3416	Protein conserved in bacteria
A7J50_RS25510	COG1643	Atp-dependent helicase
A7J50_RS25520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7J50_RS25530	COG1522	sequence-specific DNA binding
A7J50_RS25545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7J50_RS25550	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS25565	COG0352	thiamine-phosphate diphosphorylase activity
A7J50_RS25570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7J50_RS25585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7J50_RS25590	COG1702	phosphate starvation-inducible protein PhoH
A7J50_RS25595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7J50_RS25600	COG4535	Mg2 and Co2 transporter CorC
A7J50_RS25605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7J50_RS25620	COG0495	leucyl-tRNA aminoacylation
A7J50_RS25630	COG1466	dna polymerase III delta subunit
A7J50_RS25640	COG2951	lytic endotransglycosylase activity
A7J50_RS25645	COG1619	proteins homologs of microcin C7 resistance protein MccF
A7J50_RS25650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7J50_RS25655	COG0321	lipoyl(octanoyl) transferase activity
A7J50_RS25660	COG2921	Belongs to the UPF0250 family
A7J50_RS25665	COG1686	Belongs to the peptidase S11 family
A7J50_RS25675	COG2951	lytic endotransglycosylase activity
A7J50_RS25680	COG0772	Belongs to the SEDS family
A7J50_RS25685	COG0768	penicillin binding
A7J50_RS25690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7J50_RS25700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7J50_RS25705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7J50_RS25710	COG2094	Belongs to the DNA glycosylase MPG family
A7J50_RS25715	COG0586	Pfam SNARE associated Golgi protein
A7J50_RS25725	COG1346	cytolysis
A7J50_RS25745	COG0702	epimerase
A7J50_RS25760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7J50_RS25785	COG3284	Transcriptional regulator
A7J50_RS25795	COG0531	amino acid
A7J50_RS25800	COG4303	Ethanolamine ammonia lyase large subunit
A7J50_RS25805	COG4302	ethanolamine ammonia-lyase activity
A7J50_RS25810	COG0456	acetyltransferase
A7J50_RS25815	COG0586	Pfam SNARE associated Golgi protein
A7J50_RS25820	COG3228	Belongs to the MtfA family
A7J50_RS25825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7J50_RS25840	COG1335	isochorismatase
A7J50_RS25845	COG0754	glutathionylspermidine amidase activity
A7J50_RS25855	COG3766	membrane
A7J50_RS25875	COG1842	Phage shock protein A
A7J50_RS25890	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7J50_RS25905	COG1722	exodeoxyribonuclease VII activity
A7J50_RS25910	COG0142	geranyltranstransferase activity
A7J50_RS25915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7J50_RS25920	COG4206	TonB-dependent receptor
A7J50_RS25935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7J50_RS25945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7J50_RS25950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7J50_RS25955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7J50_RS25970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7J50_RS25970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7J50_RS25975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7J50_RS25985	COG2264	protein methyltransferase activity
A7J50_RS25990	COG3118	belongs to the thioredoxin family
A7J50_RS26030	COG1201	RNA secondary structure unwinding
A7J50_RS26035	COG0668	transmembrane transport
A7J50_RS26040	COG2814	Major facilitator Superfamily
A7J50_RS26045	COG3568	Endonuclease Exonuclease Phosphatase
A7J50_RS26050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J50_RS26055	COG0392	lysyltransferase activity
A7J50_RS26070	COG1335	isochorismatase
A7J50_RS26075	COG4106	trans-aconitate 2-methyltransferase activity
A7J50_RS26080	COG0583	DNA-binding transcription factor activity
A7J50_RS26085	COG0629	single-stranded DNA binding
A7J50_RS26090	COG2814	Major facilitator Superfamily
A7J50_RS26095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7J50_RS26100	COG2193	ferroxidase activity
A7J50_RS26110	COG0203	ribosomal protein L17
A7J50_RS26115	COG0202	RNA polymerase activity
A7J50_RS26120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7J50_RS26125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7J50_RS26130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7J50_RS26135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7J50_RS26145	COG0200	Binds to the 23S rRNA
A7J50_RS26150	COG1841	ribosomal large subunit assembly
A7J50_RS26155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7J50_RS26160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7J50_RS26165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7J50_RS26170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7J50_RS26175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7J50_RS26180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7J50_RS26185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7J50_RS26190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7J50_RS26195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7J50_RS26200	COG0255	Belongs to the universal ribosomal protein uL29 family
A7J50_RS26205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7J50_RS26210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7J50_RS26215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7J50_RS26220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7J50_RS26225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7J50_RS26230	COG0089	rRNA binding
A7J50_RS26235	COG0088	Forms part of the polypeptide exit tunnel
A7J50_RS26240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7J50_RS26245	COG0051	transcription antitermination factor activity, RNA binding
A7J50_RS26250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7J50_RS26255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7J50_RS26260	COG0049	tRNA binding
A7J50_RS26265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7J50_RS26270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7J50_RS26275	COG0085	RNA polymerase activity
A7J50_RS26280	COG0222	ribosome binding
A7J50_RS26285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7J50_RS26290	COG0081	regulation of translation
A7J50_RS26295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7J50_RS26335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A7J50_RS26370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7J50_RS26375	COG0739	heme binding
A7J50_RS26380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A7J50_RS26385	COG0316	Belongs to the HesB IscA family
A7J50_RS26390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7J50_RS26395	COG1981	membrane
A7J50_RS26410	COG4221	oxidoreductase activity
A7J50_RS26415	COG0537	adenosine 5'-monophosphoramidase activity
A7J50_RS26420	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A7J50_RS26425	COG1765	OsmC-like protein
A7J50_RS26440	COG0134	indole-3-glycerol-phosphate synthase activity
A7J50_RS26445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7J50_RS26450	COG0512	Glutamine amidotransferase of anthranilate synthase
A7J50_RS26455	COG4625	pathogenesis
A7J50_RS26455	COG3240	lipase activity
A7J50_RS26460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7J50_RS26465	COG0546	phosphoglycolate phosphatase activity
A7J50_RS26470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7J50_RS26475	COG1454	alcohol dehydrogenase
A7J50_RS26485	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7J50_RS26495	COG3842	ATPase activity
A7J50_RS26500	COG2197	response regulator
A7J50_RS26515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7J50_RS26520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A7J50_RS26525	COG3178	'Phosphotransferase
A7J50_RS26530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7J50_RS26535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7J50_RS26540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7J50_RS26545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7J50_RS26550	COG2967	ApaG domain
A7J50_RS26555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7J50_RS26560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7J50_RS26565	COG2766	serine protein kinase
A7J50_RS26570	COG2718	Belongs to the UPF0229 family
A7J50_RS26575	COG2719	SpoVR family
A7J50_RS26580	COG0617	tRNA 3'-terminal CCA addition
A7J50_RS26590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7J50_RS26595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A7J50_RS26600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7J50_RS26610	COG0358	DNA primase activity
A7J50_RS26615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7J50_RS26630	COG4983	Phage plasmid primase, P4 family domain protein
A7J50_RS26665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7J50_RS26670	COG1025	Belongs to the peptidase M16 family
A7J50_RS26680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7J50_RS26685	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A7J50_RS26695	COG0535	radical SAM domain protein
A7J50_RS26700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7J50_RS26705	COG0583	DNA-binding transcription factor activity
A7J50_RS26710	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS26715	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS26725	COG1960	acyl-CoA dehydrogenase activity
A7J50_RS26745	COG2226	methyltransferase
A7J50_RS26745	COG1073	alpha beta
A7J50_RS26750	COG0156	8-amino-7-oxononanoate synthase activity
A7J50_RS26755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7J50_RS26765	COG3585	molybdate ion transport
A7J50_RS26765	COG2005	Transcriptional regulator
A7J50_RS26775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A7J50_RS26790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A7J50_RS26805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7J50_RS26810	COG1595	DNA-templated transcription, initiation
A7J50_RS26820	COG4774	siderophore transport
A7J50_RS26835	COG0625	glutathione transferase activity
A7J50_RS26840	COG4452	Inner membrane protein CreD
A7J50_RS26845	COG2205	protein histidine kinase activity
A7J50_RS26850	COG0745	RESPONSE REGULATOR receiver
A7J50_RS26855	COG4067	protein conserved in archaea
A7J50_RS26855	COG0189	ligase activity
A7J50_RS26860	COG0204	Acyl-transferase
A7J50_RS26870	COG1595	DNA-templated transcription, initiation
A7J50_RS26890	COG1063	alcohol dehydrogenase
A7J50_RS26920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7J50_RS26940	COG1017	nitric oxide dioxygenase activity
A7J50_RS26940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7J50_RS26945	COG4638	Rieske (2fe-2S)
A7J50_RS26955	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A7J50_RS26960	COG0247	lactate metabolic process
A7J50_RS26960	COG2181	nitrate reductase activity
A7J50_RS26965	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7J50_RS26965	COG1902	pentaerythritol trinitrate reductase activity
A7J50_RS27010	COG3246	L-lysine catabolic process to acetate
A7J50_RS27015	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7J50_RS27040	COG1760	l-serine dehydratase
A7J50_RS27050	COG4176	ABC-type proline glycine betaine transport system permease component
A7J50_RS27055	COG4175	Glycine betaine
A7J50_RS27060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7J50_RS27065	COG1309	transcriptional regulator
A7J50_RS27070	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS27075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7J50_RS27095	COG0477	Major facilitator Superfamily
A7J50_RS27100	COG0513	Belongs to the DEAD box helicase family
A7J50_RS27105	COG2081	HI0933 family
A7J50_RS27110	COG1289	transmembrane transporter activity
A7J50_RS27120	COG2153	protein acetylation
A7J50_RS27130	COG1451	nucleotide metabolic process
A7J50_RS27170	COG0126	phosphoglycerate kinase activity
A7J50_RS27175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7J50_RS27180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7J50_RS27185	COG0640	Transcriptional regulator
A7J50_RS27190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7J50_RS27200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7J50_RS27205	COG1422	Protein of unknown function (DUF1090)
A7J50_RS27235	COG2116	formate transmembrane transporter activity
A7J50_RS27245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A7J50_RS27250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A7J50_RS27260	COG0513	Belongs to the DEAD box helicase family
A7J50_RS27270	COG0583	DNA-binding transcription factor activity
A7J50_RS27275	COG2353	YceI-like domain
A7J50_RS27280	COG3038	cytochrome b561
A7J50_RS27290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7J50_RS27295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS27315	COG1272	protein, Hemolysin III
A7J50_RS27345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7J50_RS27365	COG3052	prosthetic group binding
A7J50_RS27370	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A7J50_RS27405	COG0784	Response regulator, receiver
A7J50_RS27405	COG0643	Histidine kinase
A7J50_RS27405	COG2198	Histidine kinase
A7J50_RS27430	COG0189	ligase activity
A7J50_RS27440	COG1678	Uncharacterized ACR, COG1678
A7J50_RS27445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7J50_RS27450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7J50_RS27455	COG0540	Belongs to the ATCase OTCase family
A7J50_RS27460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7J50_RS27470	COG0791	NLP P60 protein
A7J50_RS27495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7J50_RS27500	COG2813	Specifically methylates the guanine in position
A7J50_RS27500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7J50_RS27510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7J50_RS27515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7J50_RS27525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7J50_RS27530	COG2022	thiamine diphosphate biosynthetic process
A7J50_RS27540	COG2363	Small membrane protein
A7J50_RS27545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7J50_RS27555	COG2177	Part of the ABC transporter FtsEX involved in
A7J50_RS27560	COG2884	Cell division ATP-binding protein ftsE
A7J50_RS27565	COG0552	protein localization to endoplasmic reticulum
A7J50_RS27570	COG0612	Peptidase, M16
A7J50_RS27575	COG0612	Peptidase, M16
A7J50_RS27580	COG0742	ribosomal rna small subunit methyltransferase
A7J50_RS27585	COG0429	hydrolase of the alpha beta-hydrolase fold
A7J50_RS27595	COG1309	transcriptional regulator
A7J50_RS27610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7J50_RS27615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7J50_RS27620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7J50_RS27625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7J50_RS27635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7J50_RS27640	COG2814	Major facilitator Superfamily
A7J50_RS27645	COG0129	dihydroxy-acid dehydratase activity
A7J50_RS27655	COG1823	symporter activity
A7J50_RS27670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7J50_RS27685	COG1840	ABC-type Fe3 transport system, periplasmic component
A7J50_RS27690	COG1178	ABC-type Fe3 transport system permease component
A7J50_RS27695	COG3842	ATPase activity
A7J50_RS27700	COG0583	DNA-binding transcription factor activity
A7J50_RS27710	COG0789	Transcriptional regulator
A7J50_RS27715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A7J50_RS27720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7J50_RS27735	COG0494	nUDIX hydrolase
A7J50_RS27750	COG0702	epimerase
A7J50_RS27760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7J50_RS27765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7J50_RS27770	COG3204	pilus organization
A7J50_RS27775	COG3204	pilus organization
A7J50_RS27780	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7J50_RS27785	COG0277	FAD linked oxidase domain protein
A7J50_RS27790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7J50_RS27800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS27805	COG1683	Conserved Protein
A7J50_RS27860	COG4977	sequence-specific DNA binding
A7J50_RS27860	COG1917	Cupin 2, conserved barrel domain protein
A7J50_RS27865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7J50_RS27880	COG1177	transmembrane transport
A7J50_RS27885	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7J50_RS27890	COG3842	ATPase activity
A7J50_RS27910	COG0174	glutamine synthetase
A7J50_RS27915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7J50_RS27920	COG0174	glutamine synthetase
A7J50_RS27935	COG1116	anion transmembrane transporter activity
A7J50_RS27940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7J50_RS27950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7J50_RS27955	COG0431	NADPH-dependent FMN reductase
A7J50_RS27960	COG0450	alkyl hydroperoxide reductase
A7J50_RS27970	COG4521	taurine ABC transporter
A7J50_RS27975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7J50_RS27975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7J50_RS27990	COG1522	sequence-specific DNA binding
A7J50_RS28000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7J50_RS28005	COG0330	HflC and HflK could
A7J50_RS28020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7J50_RS28025	COG0509	glycine decarboxylation via glycine cleavage system
A7J50_RS28030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7J50_RS28035	COG1178	ABC-type Fe3 transport system permease component
A7J50_RS28045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J50_RS28055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7J50_RS28060	COG0006	proline dipeptidase activity
A7J50_RS28065	COG3079	Belongs to the UPF0149 family
A7J50_RS28085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7J50_RS28095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7J50_RS28100	COG0842	Transport permease protein
A7J50_RS28100	COG1129	ABC transporter
A7J50_RS28105	COG0842	Transport permease protein
A7J50_RS28120	COG2271	Major facilitator Superfamily
A7J50_RS28145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7J50_RS28165	COG2186	Transcriptional regulator
A7J50_RS28170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7J50_RS28175	COG0765	amino acid transport
A7J50_RS28180	COG0765	amino acid transport
A7J50_RS28185	COG1126	abc transporter atp-binding protein
A7J50_RS28195	COG3188	usher protein
A7J50_RS28200	COG3121	Chaperone
A7J50_RS28210	COG0248	Ppx GppA phosphatase
A7J50_RS28215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7J50_RS28225	COG0586	Pfam SNARE associated Golgi protein
A7J50_RS28235	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A7J50_RS28240	COG1671	Belongs to the UPF0178 family
A7J50_RS28245	COG0672	)-iron permease
A7J50_RS28270	COG1280	lysine exporter protein (LysE YggA)
A7J50_RS28280	COG0488	(ABC) transporter
A7J50_RS28305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A7J50_RS28325	COG0181	hydroxymethylbilane synthase activity
A7J50_RS28335	COG0165	Argininosuccinate lyase
A7J50_RS28340	COG0625	glutathione transferase activity
A7J50_RS28355	COG3072	Adenylate cyclase
A7J50_RS28360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7J50_RS28370	COG1965	Belongs to the frataxin family
A7J50_RS28375	COG0019	diaminopimelate decarboxylase activity
A7J50_RS28380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7J50_RS28390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A7J50_RS28395	COG1011	Hydrolase
A7J50_RS28405	COG0432	Pfam Uncharacterised protein family UPF0047
A7J50_RS28410	COG0004	ammonium transporteR
A7J50_RS28415	COG0347	Belongs to the P(II) protein family
A7J50_RS28425	COG0606	chelatase, subunit chli
A7J50_RS28440	COG0840	transmembrane signaling receptor activity
A7J50_RS28445	COG0583	DNA-binding transcription factor activity
A7J50_RS28450	COG0534	Mate efflux family protein
A7J50_RS28465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7J50_RS28470	COG0427	acetyl-CoA hydrolase
A7J50_RS28475	COG5310	Homospermidine synthase
A7J50_RS28505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7J50_RS28510	COG0251	oxidation-reduction process
A7J50_RS28515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS28530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7J50_RS28540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7J50_RS28545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J50_RS28555	COG1012	belongs to the aldehyde dehydrogenase family
A7J50_RS28565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7J50_RS28570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7J50_RS28575	COG0747	negative chemotaxis
A7J50_RS28580	COG2003	Belongs to the UPF0758 family
A7J50_RS28585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7J50_RS28590	COG0756	dUTP diphosphatase activity
A7J50_RS28595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7J50_RS28600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7J50_RS28605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7J50_RS28610	COG0708	Exodeoxyribonuclease III
A7J50_RS28620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7J50_RS28625	COG1561	YicC-like family, N-terminal region
A7J50_RS28630	COG0194	GDP metabolic process
A7J50_RS28635	COG1758	RNA polymerase activity
A7J50_RS28640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7J50_RS28665	COG0848	biopolymer transport protein
A7J50_RS28690	COG0583	DNA-binding transcription factor activity
A7J50_RS28695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7J50_RS28725	COG1136	(ABC) transporter
A7J50_RS28730	COG2815	serine threonine protein kinase
A7J50_RS28730	COG0515	serine threonine protein kinase
A7J50_RS28845	COG3161	chorismate lyase activity
A7J50_RS28850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7J50_RS28870	COG1253	flavin adenine dinucleotide binding
A7J50_RS28890	COG0704	Plays a role in the regulation of phosphate uptake
A7J50_RS28895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7J50_RS28900	COG0573	inorganic phosphate transmembrane transporter activity
A7J50_RS28915	COG0477	Major facilitator Superfamily
A7J50_RS28920	COG1607	acyl-coa hydrolase
A7J50_RS28925	COG0676	glucose-6-phosphate 1-epimerase activity
A7J50_RS28950	COG0583	DNA-binding transcription factor activity
A7J50_RS28955	COG1027	Aspartate ammonia-lyase
A7J50_RS28965	COG1115	amino acid carrier protein
A7J50_RS28970	COG0252	asparaginase activity
A7J50_RS28995	COG2808	Putative FMN-binding domain
A7J50_RS29015	COG5016	pyruvate
A7J50_RS29015	COG0511	ligase activity, forming carbon-carbon bonds
A7J50_RS29020	COG0439	Biotin carboxylase
A7J50_RS29025	COG0583	DNA-binding transcription factor activity
A7J50_RS29035	COG3300	MHYT domain
A7J50_RS29035	COG5001	Diguanylate cyclase
A7J50_RS29040	COG0210	DNA helicase
A7J50_RS29055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7J50_RS29055	COG4651	solute:proton antiporter activity
A7J50_RS29060	COG1607	acyl-coa hydrolase
A7J50_RS29065	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A7J50_RS29075	COG0523	cobalamin synthesis protein
A7J50_RS29100	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7J50_RS29105	COG1469	GTP cyclohydrolase I activity
A7J50_RS29110	COG1121	(ABC) transporter
A7J50_RS29125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7J50_RS29135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7J50_RS29145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7J50_RS29150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7J50_RS29160	COG3220	belongs to the UPF0276 family
A7J50_RS29190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7J50_RS29195	COG2267	carboxylic ester hydrolase activity
A7J50_RS29200	COG2453	phosphatase
A7J50_RS29200	COG0671	phosphoesterase, PA-phosphatase related
A7J50_RS29215	COG4589	Belongs to the CDS family
A7J50_RS29220	COG1522	sequence-specific DNA binding
A7J50_RS29225	COG1280	lysine exporter protein (LysE YggA)
A7J50_RS29230	COG2373	Large extracellular alpha-helical protein
A7J50_RS29235	COG4953	penicillin-binding protein 1C
A7J50_RS29255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7J50_RS29260	COG1349	DNA-binding transcription factor activity
A7J50_RS29265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7J50_RS29270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7J50_RS29275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7J50_RS29280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7J50_RS29285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7J50_RS29290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7J50_RS29295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7J50_RS29305	COG0356	it plays a direct role in the translocation of protons across the membrane
A7J50_RS29310	COG3312	ion transport
A7J50_RS29315	COG1475	DNA binding
A7J50_RS29320	COG1192	Involved in chromosome partitioning
A7J50_RS29325	COG0357	Ribosomal RNA small subunit methyltransferase G
A7J50_RS29330	COG0445	tRNA wobble uridine modification
A7J50_RS29335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7J50_RS29340	COG0706	membrane insertase activity
A7J50_RS29360	COG0592	DNA-directed DNA polymerase activity
A7J50_RS29375	COG0187	DNA topoisomerase II activity
A7J50_RS29485	COG0751	glycine-tRNA ligase activity
A7J50_RS29525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7J50_RS29615	COG2271	Major facilitator Superfamily
A7J50_RS29915	COG1127	ABC transporter
A7J50_RS30160	COG0751	glycine-tRNA ligase activity
A7J50_RS30215	COG5487	UPF0391 membrane protein