locus-tag	class	description
N015_RS00010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N015_RS00035	COG0427	acetyl-CoA hydrolase
N015_RS00050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N015_RS00060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS00065	COG1522	sequence-specific DNA binding
N015_RS00075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS00085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N015_RS00090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N015_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS00115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N015_RS00120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N015_RS00125	COG0747	negative chemotaxis
N015_RS00130	COG2003	Belongs to the UPF0758 family
N015_RS00135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N015_RS00140	COG0756	dUTP diphosphatase activity
N015_RS00145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N015_RS00150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N015_RS00160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N015_RS00165	COG0708	Exodeoxyribonuclease III
N015_RS00175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N015_RS00180	COG1561	YicC-like family, N-terminal region
N015_RS00185	COG0194	GDP metabolic process
N015_RS00190	COG1758	RNA polymerase activity
N015_RS00195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N015_RS00230	COG0848	biopolymer transport protein
N015_RS00245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N015_RS00260	COG2851	Citrate transporter
N015_RS00265	COG1283	sodium-dependent phosphate transmembrane transporter activity
N015_RS00270	COG0612	Peptidase, M16
N015_RS00280	COG0700	Nucleoside recognition
N015_RS00285	COG1301	dicarboxylic acid transport
N015_RS00310	COG2204	response regulator
N015_RS00315	COG5002	protein histidine kinase activity
N015_RS00320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N015_RS00325	COG3023	N-Acetylmuramoyl-L-alanine amidase
N015_RS00330	COG3706	GGDEF domain
N015_RS00330	COG0745	RESPONSE REGULATOR receiver
N015_RS00340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N015_RS00350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N015_RS00370	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N015_RS00375	COG0735	belongs to the Fur family
N015_RS00380	COG1121	(ABC) transporter
N015_RS00385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N015_RS00400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N015_RS00405	COG2011	ABC-type metal ion transport system permease component
N015_RS00410	COG1464	Belongs to the NlpA lipoprotein family
N015_RS00425	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
N015_RS00435	COG0659	secondary active sulfate transmembrane transporter activity
N015_RS00460	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N015_RS00465	COG0339	signal peptide processing
N015_RS00470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N015_RS00495	COG1764	response to oxidative stress
N015_RS00500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N015_RS00525	COG0133	tryptophan synthase activity
N015_RS00530	COG0159	tryptophan synthase activity
N015_RS00570	COG0583	DNA-binding transcription factor activity
N015_RS00575	COG3119	arylsulfatase activity
N015_RS00590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N015_RS00595	COG0408	coproporphyrinogen oxidase activity
N015_RS00605	COG0009	L-threonylcarbamoyladenylate synthase
N015_RS00610	COG0758	DNA mediated transformation
N015_RS00620	COG0242	peptide deformylase activity
N015_RS00625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N015_RS00630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N015_RS00635	COG0569	domain protein
N015_RS00645	COG2818	Glycosylase
N015_RS00650	COG0752	glycyl-tRNA synthetase alpha subunit
N015_RS00655	COG0751	glycine-tRNA ligase activity
N015_RS00660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N015_RS00760	COG0583	DNA-binding transcription factor activity
N015_RS00765	COG0019	diaminopimelate decarboxylase activity
N015_RS00770	COG0187	DNA topoisomerase II activity
N015_RS00775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N015_RS00780	COG0592	DNA-directed DNA polymerase activity
N015_RS00785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N015_RS00790	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N015_RS00795	COG0594	ribonuclease P activity
N015_RS00800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N015_RS00805	COG0706	membrane insertase activity
N015_RS00810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N015_RS00815	COG0445	tRNA wobble uridine modification
N015_RS00820	COG0357	Ribosomal RNA small subunit methyltransferase G
N015_RS00825	COG1192	Involved in chromosome partitioning
N015_RS00830	COG1475	DNA binding
N015_RS00835	COG3312	ion transport
N015_RS00840	COG0356	it plays a direct role in the translocation of protons across the membrane
N015_RS00850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N015_RS00855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N015_RS00860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N015_RS00865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N015_RS00870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N015_RS00875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N015_RS00880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N015_RS00885	COG1349	DNA-binding transcription factor activity
N015_RS00890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N015_RS00905	COG0840	transmembrane signaling receptor activity
N015_RS00905	COG3290	protein histidine kinase activity
N015_RS00910	COG2890	protein-(glutamine-N5) methyltransferase activity
N015_RS00930	COG0840	transmembrane signaling receptor activity
N015_RS00945	COG1116	anion transmembrane transporter activity
N015_RS00950	COG4191	Histidine kinase
N015_RS00955	COG4566	intracellular signal transduction
N015_RS00975	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
N015_RS00980	COG4589	Belongs to the CDS family
N015_RS00995	COG0671	phosphoesterase, PA-phosphatase related
N015_RS00995	COG2453	phosphatase
N015_RS01000	COG2267	carboxylic ester hydrolase activity
N015_RS01005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N015_RS01025	COG2217	Heavy metal translocating P-type atpase
N015_RS01030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N015_RS01035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N015_RS01045	COG0860	N-Acetylmuramoyl-L-alanine amidase
N015_RS01070	COG0523	cobalamin synthesis protein
N015_RS01080	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
N015_RS01085	COG1607	acyl-coa hydrolase
N015_RS01090	COG4651	solute:proton antiporter activity
N015_RS01090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N015_RS01105	COG0210	DNA helicase
N015_RS01115	COG1737	Transcriptional regulator
N015_RS01125	COG0583	DNA-binding transcription factor activity
N015_RS01130	COG0439	Biotin carboxylase
N015_RS01135	COG5016	pyruvate
N015_RS01135	COG0511	ligase activity, forming carbon-carbon bonds
N015_RS01150	COG2808	Putative FMN-binding domain
N015_RS01160	COG2391	methyltransferase activity
N015_RS01165	COG3781	membrane
N015_RS01170	COG0252	asparaginase activity
N015_RS01175	COG1115	amino acid carrier protein
N015_RS01180	COG1027	Aspartate ammonia-lyase
N015_RS01185	COG0583	DNA-binding transcription factor activity
N015_RS01220	COG1607	acyl-coa hydrolase
N015_RS01240	COG0581	inorganic phosphate transmembrane transporter activity
N015_RS01245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N015_RS01250	COG0704	Plays a role in the regulation of phosphate uptake
N015_RS01265	COG0739	heme binding
N015_RS01270	COG1253	flavin adenine dinucleotide binding
N015_RS01290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N015_RS01295	COG3161	chorismate lyase activity
N015_RS01350	COG0427	acetyl-CoA hydrolase
N015_RS01355	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N015_RS01360	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N015_RS01365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N015_RS01370	COG0583	DNA-binding transcription factor activity
N015_RS01375	COG1960	acyl-CoA dehydrogenase activity
N015_RS01425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N015_RS01440	COG1802	Transcriptional regulator
N015_RS01445	COG0667	Aldo Keto reductase
N015_RS01450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N015_RS01475	COG3209	COG3209 Rhs family protein
N015_RS01485	COG3501	Rhs element vgr protein
N015_RS01500	COG3209	COG3209 Rhs family protein
N015_RS01505	COG3501	Rhs element vgr protein
N015_RS01590	COG0631	protein serine/threonine phosphatase activity
N015_RS01595	COG0515	serine threonine protein kinase
N015_RS01595	COG2815	serine threonine protein kinase
N015_RS01600	COG1136	(ABC) transporter
N015_RS01630	COG0318	PFAM AMP-dependent synthetase and ligase
N015_RS01640	COG0514	ATP-dependent DNA helicase (RecQ)
N015_RS01655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N015_RS01660	COG0583	DNA-binding transcription factor activity
N015_RS01665	COG1652	LysM domain
N015_RS01670	COG1011	Hydrolase
N015_RS01675	COG0494	nUDIX hydrolase
N015_RS01680	COG1218	3'(2'),5'-bisphosphate nucleotidase
N015_RS01715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N015_RS01720	COG2957	Belongs to the agmatine deiminase family
N015_RS01750	COG3077	Addiction module antitoxin, RelB DinJ family
N015_RS01775	COG3436	PFAM IS66 Orf2 family protein
N015_RS01780	COG1204	response to ionizing radiation
N015_RS01795	COG5001	Diguanylate cyclase
N015_RS01795	COG4251	negative regulation of phosphorylation
N015_RS01795	COG2203	Gaf domain
N015_RS01795	COG3706	GGDEF domain
N015_RS01860	COG4695	Portal protein
N015_RS02005	COG0484	heat shock protein binding
N015_RS02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS02095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N015_RS02100	COG1194	a g-specific adenine glycosylase
N015_RS02120	COG1522	sequence-specific DNA binding
N015_RS02130	COG1448	Aminotransferase
N015_RS02135	COG0131	Imidazoleglycerol-phosphate dehydratase
N015_RS02140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N015_RS02150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N015_RS02155	COG0107	imidazoleglycerol-phosphate synthase activity
N015_RS02165	COG2861	carbohydrate metabolic process
N015_RS02170	COG0793	Belongs to the peptidase S41A family
N015_RS02175	COG4942	peptidase
N015_RS02180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N015_RS02185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N015_RS02195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N015_RS02200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N015_RS02210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N015_RS02215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N015_RS02220	COG4521	taurine ABC transporter
N015_RS02230	COG0450	alkyl hydroperoxide reductase
N015_RS02235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N015_RS02240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N015_RS02245	COG1116	anion transmembrane transporter activity
N015_RS02260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N015_RS02265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N015_RS02275	COG1522	sequence-specific DNA binding
N015_RS02280	COG4172	Belongs to the ABC transporter superfamily
N015_RS02285	COG4239	(ABC) transporter, permease
N015_RS02290	COG4174	ABC transporter (Permease)
N015_RS02330	COG1522	sequence-specific DNA binding
N015_RS02335	COG3152	Membrane
N015_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS02355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N015_RS02365	COG0745	RESPONSE REGULATOR receiver
N015_RS02370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N015_RS02375	COG0789	Transcriptional regulator
N015_RS02390	COG1228	amidohydrolase
N015_RS02400	COG2986	histidine ammonia-lyase
N015_RS02405	COG2986	histidine ammonia-lyase
N015_RS02410	COG4175	Glycine betaine
N015_RS02410	COG0517	IMP dehydrogenase activity
N015_RS02415	COG4176	ABC-type proline glycine betaine transport system permease component
N015_RS02425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N015_RS02445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N015_RS02455	COG2188	Transcriptional regulator
N015_RS02460	COG0402	S-adenosylhomocysteine deaminase activity
N015_RS02480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N015_RS02495	COG0058	SHG alpha-glucan phosphorylase activity
N015_RS02500	COG0596	Alpha beta hydrolase
N015_RS02505	COG1490	D-aminoacyl-tRNA deacylase activity
N015_RS02510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
N015_RS02515	COG2943	transferase activity, transferring hexosyl groups
N015_RS02520	COG0840	transmembrane signaling receptor activity
N015_RS02525	COG0840	transmembrane signaling receptor activity
N015_RS02540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N015_RS02545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N015_RS02550	COG0140	phosphoribosyl-ATP diphosphatase activity
N015_RS02555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N015_RS02560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N015_RS02570	COG2226	methyltransferase
N015_RS02625	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N015_RS02630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N015_RS02640	COG0018	arginyl-trna synthetase
N015_RS02645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N015_RS02650	COG0254	rRNA binding
N015_RS02660	COG0281	malic enzyme
N015_RS02665	COG1160	GTP binding
N015_RS02685	COG0129	dihydroxy-acid dehydratase activity
N015_RS02695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N015_RS02700	COG0693	protein deglycase activity
N015_RS02710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N015_RS02720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N015_RS02725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N015_RS02745	COG0429	hydrolase of the alpha beta-hydrolase fold
N015_RS02750	COG0742	ribosomal rna small subunit methyltransferase
N015_RS02755	COG0612	Peptidase, M16
N015_RS02760	COG0612	Peptidase, M16
N015_RS02770	COG0612	Peptidase, M16
N015_RS02775	COG0552	protein localization to endoplasmic reticulum
N015_RS02780	COG2884	Cell division ATP-binding protein ftsE
N015_RS02785	COG2177	Part of the ABC transporter FtsEX involved in
N015_RS02805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N015_RS02810	COG2363	Small membrane protein
N015_RS02820	COG2022	thiamine diphosphate biosynthetic process
N015_RS02825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N015_RS02835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N015_RS02840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N015_RS02850	COG2813	Specifically methylates the guanine in position
N015_RS02850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N015_RS02855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N015_RS02880	COG0791	NLP P60 protein
N015_RS02890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N015_RS02895	COG0540	Belongs to the ATCase OTCase family
N015_RS02900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N015_RS02905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N015_RS02910	COG1678	Uncharacterized ACR, COG1678
N015_RS02920	COG0189	ligase activity
N015_RS02945	COG2198	Histidine kinase
N015_RS02945	COG0643	Histidine kinase
N015_RS02955	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N015_RS02960	COG3264	Mechanosensitive ion channel
N015_RS02960	COG1196	nuclear chromosome segregation
N015_RS02965	COG3263	regulation of cellular component size
N015_RS02980	COG1960	acyl-CoA dehydrogenase activity
N015_RS02985	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N015_RS02985	COG0506	proline dehydrogenase activity
N015_RS02985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N015_RS02990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N015_RS03005	COG1451	nucleotide metabolic process
N015_RS03015	COG2153	protein acetylation
N015_RS03025	COG1289	transmembrane transporter activity
N015_RS03030	COG2081	HI0933 family
N015_RS03035	COG0513	Belongs to the DEAD box helicase family
N015_RS03040	COG0477	Major facilitator Superfamily
N015_RS03055	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
N015_RS03060	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS03065	COG1309	transcriptional regulator
N015_RS03070	COG4175	Glycine betaine
N015_RS03110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N015_RS03115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N015_RS03135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N015_RS03140	COG0859	PFAM glycosyl transferase family 9
N015_RS03145	COG0859	PFAM glycosyl transferase family 9
N015_RS03150	COG0438	transferase activity, transferring glycosyl groups
N015_RS03180	COG2192	nodulation
N015_RS03185	COG0438	transferase activity, transferring glycosyl groups
N015_RS03220	COG1132	(ABC) transporter
N015_RS03225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N015_RS03225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N015_RS03235	COG0667	Aldo Keto reductase
N015_RS03250	COG1519	Transferase
N015_RS03255	COG1538	Outer membrane efflux protein
N015_RS03260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N015_RS03275	COG0494	nUDIX hydrolase
N015_RS03320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N015_RS03325	COG3150	esterase
N015_RS03340	COG3577	Aspartyl protease
N015_RS03360	COG0560	Phosphoserine phosphatase
N015_RS03360	COG3830	Belongs to the UPF0237 family
N015_RS03390	COG1162	GTPase activity
N015_RS03395	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N015_RS03400	COG2860	membrane
N015_RS03410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N015_RS03410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N015_RS03415	COG0802	atpase or kinase
N015_RS03420	COG0860	N-Acetylmuramoyl-L-alanine amidase
N015_RS03425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N015_RS03430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N015_RS03435	COG1923	regulation of RNA biosynthetic process
N015_RS03440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N015_RS03445	COG0330	HflC and HflK could
N015_RS03450	COG0330	HflC and HflK could
N015_RS03455	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N015_RS03460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N015_RS03485	COG0557	exoribonuclease II activity
N015_RS03490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N015_RS03495	COG0360	Binds together with S18 to 16S ribosomal RNA
N015_RS03500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N015_RS03510	COG0359	binds to the 23S rRNA
N015_RS03515	COG0305	Participates in initiation and elongation during chromosome replication
N015_RS03520	COG1032	radical SAM domain protein
N015_RS03530	COG2307	Protein conserved in bacteria
N015_RS03530	COG2308	Evidence 4 Homologs of previously reported genes of
N015_RS03545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N015_RS03550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N015_RS03555	COG0583	DNA-binding transcription factor activity
N015_RS03565	COG0559	Belongs to the binding-protein-dependent transport system permease family
N015_RS03580	COG0410	ABC transporter
N015_RS03585	COG4221	oxidoreductase activity
N015_RS03600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N015_RS03605	COG0830	nickel cation binding
N015_RS03610	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N015_RS03625	COG2982	Protein involved in outer membrane biogenesis
N015_RS03640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N015_RS03650	COG0697	spore germination
N015_RS03665	COG0443	Heat shock 70 kDa protein
N015_RS03670	COG0484	heat shock protein binding
N015_RS03690	COG0804	urea catabolic process
N015_RS03695	COG0832	Belongs to the urease beta subunit family
N015_RS03710	COG0831	urea catabolic process
N015_RS03715	COG0829	nickel cation binding
N015_RS03720	COG0410	ABC transporter
N015_RS03725	COG0411	ABC transporter
N015_RS03735	COG0559	Belongs to the binding-protein-dependent transport system permease family
N015_RS03740	COG0683	leucine binding
N015_RS03780	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
N015_RS03790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N015_RS03830	COG2095	MarC family integral membrane protein
N015_RS03840	COG0151	Belongs to the GarS family
N015_RS03845	COG0138	bifunctional purine biosynthesis protein purh
N015_RS03855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N015_RS03865	COG2264	protein methyltransferase activity
N015_RS03880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N015_RS03895	COG4953	penicillin-binding protein 1C
N015_RS03905	COG2373	Large extracellular alpha-helical protein
N015_RS03910	COG0534	Mate efflux family protein
N015_RS03925	COG1166	arginine decarboxylase activity
N015_RS03930	COG0023	Translation Initiation Factor
N015_RS03945	COG3706	GGDEF domain
N015_RS03945	COG0745	RESPONSE REGULATOR receiver
N015_RS03975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N015_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS03995	COG0183	Belongs to the thiolase family
N015_RS04015	COG2207	Transcriptional regulator
N015_RS04030	COG2217	Heavy metal translocating P-type atpase
N015_RS04050	COG2814	Major facilitator Superfamily
N015_RS04060	COG0583	DNA-binding transcription factor activity
N015_RS04070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N015_RS04085	COG1120	ATPase activity
N015_RS04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N015_RS04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N015_RS04100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
N015_RS04105	COG0387	Pfam Sodium calcium exchanger
N015_RS04125	COG0789	Transcriptional regulator
N015_RS04155	COG1309	transcriptional regulator
N015_RS04160	COG2233	PERMEase
N015_RS04210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N015_RS04215	COG1074	ATP-dependent DNA helicase activity
N015_RS04220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N015_RS04245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N015_RS04265	COG4771	TonB-dependent receptor
N015_RS04275	COG2205	protein histidine kinase activity
N015_RS04280	COG0745	RESPONSE REGULATOR receiver
N015_RS04295	COG3639	organic phosphonate transmembrane transporter activity
N015_RS04300	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N015_RS04305	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
N015_RS04310	COG0709	Synthesizes selenophosphate from selenide and ATP
N015_RS04315	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
N015_RS04320	COG0583	DNA-binding transcription factor activity
N015_RS04335	COG2249	NAD(P)H dehydrogenase (quinone) activity
N015_RS04340	COG0583	DNA-binding transcription factor activity
N015_RS04345	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N015_RS04370	COG0019	diaminopimelate decarboxylase activity
N015_RS04380	COG3128	pkhd-type hydroxylase
N015_RS04385	COG4774	siderophore transport
N015_RS04390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N015_RS04395	COG4608	Belongs to the ABC transporter superfamily
N015_RS04400	COG0444	Belongs to the ABC transporter superfamily
N015_RS04405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N015_RS04410	COG0601	transmembrane transport
N015_RS04415	COG0747	negative chemotaxis
N015_RS04425	COG0747	negative chemotaxis
N015_RS04430	COG0747	negative chemotaxis
N015_RS04435	COG0747	negative chemotaxis
N015_RS04455	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
N015_RS04460	COG4178	(ABC) transporter
N015_RS04465	COG2186	Transcriptional regulator
N015_RS04470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N015_RS04475	COG2271	Major facilitator Superfamily
N015_RS04480	COG2721	sulfolactate sulfo-lyase activity
N015_RS04510	COG0730	response to heat
N015_RS04515	COG5001	Diguanylate cyclase
N015_RS04515	COG4251	negative regulation of phosphorylation
N015_RS04515	COG3706	GGDEF domain
N015_RS04515	COG2203	Gaf domain
N015_RS04640	COG2267	carboxylic ester hydrolase activity
N015_RS04645	COG2197	response regulator
N015_RS04650	COG0601	transmembrane transport
N015_RS04660	COG0444	Belongs to the ABC transporter superfamily
N015_RS04665	COG4608	Belongs to the ABC transporter superfamily
N015_RS04680	COG1802	Transcriptional regulator
N015_RS04700	COG1335	isochorismatase
N015_RS04705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N015_RS04740	COG4336	lyase activity
N015_RS04745	COG0583	DNA-binding transcription factor activity
N015_RS04750	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N015_RS04770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N015_RS04780	COG3436	PFAM IS66 Orf2 family protein
N015_RS04800	COG0582	viral genome integration into host DNA
N015_RS04830	COG0247	lactate metabolic process
N015_RS04835	COG1620	l-lactate permease
N015_RS04840	COG2186	Transcriptional regulator
N015_RS04845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N015_RS04850	COG0733	neurotransmitter:sodium symporter activity
N015_RS04860	COG2914	Belongs to the UPF0125 (RnfH) family
N015_RS04865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N015_RS04875	COG0497	DNA recombination
N015_RS04880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N015_RS04885	COG0443	Heat shock 70 kDa protein
N015_RS04890	COG0484	heat shock protein binding
N015_RS04900	COG0505	Belongs to the CarA family
N015_RS04905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N015_RS04910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N015_RS04920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N015_RS04925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N015_RS04930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N015_RS04935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N015_RS04940	COG0149	triose-phosphate isomerase activity
N015_RS04945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N015_RS04960	COG0779	Required for maturation of 30S ribosomal subunits
N015_RS04965	COG0195	Participates in both transcription termination and antitermination
N015_RS04970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N015_RS04975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N015_RS04980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N015_RS04985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N015_RS04990	COG1185	polyribonucleotide nucleotidyltransferase activity
N015_RS04995	COG2823	Periplasmic or secreted lipoprotein
N015_RS05010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N015_RS05030	COG0166	Belongs to the GPI family
N015_RS05040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N015_RS05045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N015_RS05060	COG2204	response regulator
N015_RS05065	COG4191	Histidine kinase
N015_RS05075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N015_RS05080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N015_RS05085	COG0436	Aminotransferase
N015_RS05090	COG1489	DNA binding
N015_RS05100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N015_RS05115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N015_RS05135	COG0028	Belongs to the TPP enzyme family
N015_RS05145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N015_RS05150	COG1183	phosphatidylcholine synthase activity
N015_RS05155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N015_RS05160	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
N015_RS05225	COG0288	reversible hydration of carbon dioxide
N015_RS05235	COG1418	mRNA catabolic process
N015_RS05240	COG2824	Alkylphosphonate utilization operon protein PhnA
N015_RS05245	COG3011	Protein conserved in bacteria
N015_RS05250	COG2814	Major facilitator Superfamily
N015_RS05275	COG5001	Diguanylate cyclase
N015_RS05275	COG4251	negative regulation of phosphorylation
N015_RS05275	COG3706	GGDEF domain
N015_RS05275	COG2203	Gaf domain
N015_RS05315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N015_RS05330	COG0193	aminoacyl-tRNA hydrolase activity
N015_RS05335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N015_RS05340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N015_RS05350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N015_RS05355	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N015_RS05365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N015_RS05370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N015_RS05380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N015_RS05385	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N015_RS05405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N015_RS05415	COG0493	'glutamate synthase
N015_RS05420	COG4221	oxidoreductase activity
N015_RS05430	COG0415	Belongs to the DNA photolyase family
N015_RS05435	COG0789	Transcriptional regulator
N015_RS05450	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
N015_RS05455	COG1090	epimerase
N015_RS05460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N015_RS05470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N015_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS05505	COG0579	oxidoreductase
N015_RS05540	COG2135	peptidase activity
N015_RS05550	COG0501	Belongs to the peptidase M48B family
N015_RS05555	COG2119	membrane
N015_RS05560	COG2813	Specifically methylates the guanine in position
N015_RS05565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N015_RS05570	COG1280	lysine exporter protein (LysE YggA)
N015_RS05575	COG0318	PFAM AMP-dependent synthetase and ligase
N015_RS05600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N015_RS05605	COG0596	Alpha beta hydrolase
N015_RS05610	COG0251	oxidation-reduction process
N015_RS05615	COG1335	isochorismatase
N015_RS05620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N015_RS05625	COG1309	transcriptional regulator
N015_RS05650	COG2885	chlorophyll binding
N015_RS05655	COG0204	Acyl-transferase
N015_RS05660	COG0857	belongs to the CobB CobQ family
N015_RS05660	COG0280	phosphate acetyltransferase
N015_RS05675	COG0386	Belongs to the glutathione peroxidase family
N015_RS05705	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N015_RS05710	COG0450	alkyl hydroperoxide reductase
N015_RS05715	COG0492	ferredoxin-NADP+ reductase activity
N015_RS05730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N015_RS05735	COG0302	gtp cyclohydrolase
N015_RS05750	COG0789	Transcriptional regulator
N015_RS05760	COG1366	Belongs to the anti-sigma-factor antagonist family
N015_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS05800	COG1215	transferase activity, transferring glycosyl groups
N015_RS05810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N015_RS05840	COG4772	TonB-dependent receptor
N015_RS05845	COG3712	iron ion homeostasis
N015_RS05875	COG0697	spore germination
N015_RS05880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N015_RS05885	COG0583	DNA-binding transcription factor activity
N015_RS05905	COG1566	PFAM secretion protein HlyD family protein
N015_RS05910	COG0300	oxidoreductase activity
N015_RS05930	COG0662	Cupin 2, conserved barrel domain protein
N015_RS05930	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N015_RS05945	COG1696	Membrane protein involved in D-alanine export
N015_RS05960	COG3420	alginic acid biosynthetic process
N015_RS05970	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N015_RS05975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS05980	COG1215	transferase activity, transferring glycosyl groups
N015_RS05990	COG3022	response to hydroperoxide
N015_RS06000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N015_RS06005	COG0315	cyclic pyranopterin monophosphate synthase activity
N015_RS06010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N015_RS06035	COG0513	Belongs to the DEAD box helicase family
N015_RS06045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS06050	COG4597	amino acid ABC transporter
N015_RS06055	COG0765	amino acid transport
N015_RS06060	COG1126	abc transporter atp-binding protein
N015_RS06070	COG2807	transmembrane transport
N015_RS06080	COG2827	Endonuclease containing a URI domain
N015_RS06100	COG3081	Nucleoid-associated protein
N015_RS06110	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
N015_RS06115	COG0525	valine-tRNA ligase activity
N015_RS06130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N015_RS06135	COG0795	lipopolysaccharide-transporting ATPase activity
N015_RS06140	COG0795	lipopolysaccharide-transporting ATPase activity
N015_RS06150	COG1278	Cold shock
N015_RS06155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N015_RS06160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N015_RS06160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N015_RS06165	COG0509	glycine decarboxylation via glycine cleavage system
N015_RS06175	COG0784	Response regulator, receiver
N015_RS06180	COG2205	protein histidine kinase activity
N015_RS06195	COG2832	Protein of unknown function (DUF454)
N015_RS06215	COG1595	DNA-templated transcription, initiation
N015_RS06235	COG0745	RESPONSE REGULATOR receiver
N015_RS06240	COG2205	protein histidine kinase activity
N015_RS06245	COG1653	transport
N015_RS06260	COG3842	ATPase activity
N015_RS06270	COG0676	glucose-6-phosphate 1-epimerase activity
N015_RS06275	COG1737	Transcriptional regulator
N015_RS06290	COG0800	Aldolase
N015_RS06295	COG3530	Putative quorum-sensing-regulated virulence factor
N015_RS06305	COG4251	negative regulation of phosphorylation
N015_RS06305	COG3706	GGDEF domain
N015_RS06305	COG5001	Diguanylate cyclase
N015_RS06305	COG2203	Gaf domain
N015_RS06310	COG5002	protein histidine kinase activity
N015_RS06340	COG3121	Chaperone
N015_RS06350	COG3121	Chaperone
N015_RS06375	COG0456	acetyltransferase
N015_RS06385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N015_RS06390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N015_RS06395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N015_RS06400	COG1845	cytochrome c oxidase, subunit III
N015_RS06410	COG0109	protoheme IX farnesyltransferase activity
N015_RS06415	COG1215	transferase activity, transferring glycosyl groups
N015_RS06425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N015_RS06485	COG3958	Transketolase
N015_RS06490	COG3959	Transketolase, thiamine diphosphate binding domain
N015_RS06495	COG2271	Major facilitator Superfamily
N015_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS06505	COG0583	DNA-binding transcription factor activity
N015_RS06520	COG3781	membrane
N015_RS06545	COG0741	lytic transglycosylase activity
N015_RS06545	COG1388	LysM domain
N015_RS06630	COG4792	protein secretion
N015_RS06640	COG4794	Type iii secretion
N015_RS06655	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N015_RS06710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N015_RS06715	COG0343	queuine tRNA-ribosyltransferase activity
N015_RS06720	COG1862	Preprotein translocase
N015_RS06735	COG3134	Outer membrane lipoprotein
N015_RS06750	COG1045	serine acetyltransferase
N015_RS06760	COG1104	cysteine desulfurase activity
N015_RS06770	COG0316	Belongs to the HesB IscA family
N015_RS06775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N015_RS06780	COG0443	Heat shock 70 kDa protein
N015_RS06785	COG0633	Ferredoxin
N015_RS06795	COG0105	UTP biosynthetic process
N015_RS06800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N015_RS06815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N015_RS06820	COG0124	histidyl-tRNA synthetase
N015_RS06835	COG1160	GTP binding
N015_RS06840	COG0436	Aminotransferase
N015_RS06855	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N015_RS06860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N015_RS06870	COG0739	heme binding
N015_RS06875	COG1570	exodeoxyribonuclease VII activity
N015_RS06895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N015_RS06895	COG0519	Catalyzes the synthesis of GMP from XMP
N015_RS06940	COG2132	Multicopper oxidase
N015_RS06945	COG0590	tRNA wobble adenosine to inosine editing
N015_RS06950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N015_RS06955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N015_RS06955	COG0047	phosphoribosylformylglycinamidine synthase activity
N015_RS06995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N015_RS07000	COG0477	Major facilitator Superfamily
N015_RS07005	COG4536	flavin adenine dinucleotide binding
N015_RS07015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N015_RS07020	COG0228	four-way junction DNA binding
N015_RS07025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N015_RS07030	COG0336	Belongs to the RNA methyltransferase TrmD family
N015_RS07035	COG0335	large ribosomal subunit rRNA binding
N015_RS07040	COG4974	Belongs to the 'phage' integrase family
N015_RS07045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N015_RS07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS07060	COG2205	protein histidine kinase activity
N015_RS07065	COG5001	Diguanylate cyclase
N015_RS07065	COG4251	negative regulation of phosphorylation
N015_RS07065	COG3706	GGDEF domain
N015_RS07065	COG2203	Gaf domain
N015_RS07085	COG4681	YaeQ
N015_RS07095	COG1902	pentaerythritol trinitrate reductase activity
N015_RS07110	COG0840	transmembrane signaling receptor activity
N015_RS07120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N015_RS07120	COG0457	Tetratricopeptide repeat
N015_RS07135	COG2201	protein-glutamate methylesterase activity
N015_RS07140	COG2203	Gaf domain
N015_RS07140	COG3706	GGDEF domain
N015_RS07140	COG5001	Diguanylate cyclase
N015_RS07140	COG4251	negative regulation of phosphorylation
N015_RS07150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N015_RS07170	COG1073	alpha beta
N015_RS07195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N015_RS07200	COG0563	adenylate kinase activity
N015_RS07235	COG0742	ribosomal rna small subunit methyltransferase
N015_RS07260	COG3126	Type III secretion system lipoprotein chaperone (YscW)
N015_RS07265	COG2937	Belongs to the GPAT DAPAT family
N015_RS07275	COG2226	methyltransferase
N015_RS07280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N015_RS07285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N015_RS07295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N015_RS07300	COG2171	N-acyltransferase activity
N015_RS07305	COG1393	Belongs to the ArsC family
N015_RS07320	COG0436	Aminotransferase
N015_RS07325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N015_RS07330	COG0024	Methionine aminopeptidase
N015_RS07335	COG0052	Belongs to the universal ribosomal protein uS2 family
N015_RS07340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N015_RS07345	COG0528	UMP kinase activity
N015_RS07350	COG0233	cytoplasmic translational termination
N015_RS07355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N015_RS07365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N015_RS07375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N015_RS07385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N015_RS07390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N015_RS07395	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N015_RS07400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N015_RS07405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N015_RS07410	COG0587	DNA-directed DNA polymerase activity
N015_RS07415	COG0825	malonyl-CoA metabolic process
N015_RS07420	COG0037	tRNA processing
N015_RS07425	COG0504	CTP synthase activity
N015_RS07430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N015_RS07435	COG0148	phosphopyruvate hydratase activity
N015_RS07445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N015_RS07455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N015_RS07460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N015_RS07465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N015_RS07470	COG0585	pseudouridine synthase activity
N015_RS07475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N015_RS07480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N015_RS07495	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N015_RS07500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N015_RS07505	COG1546	Belongs to the CinA family
N015_RS07510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N015_RS07515	COG2137	regulation of response to DNA damage stimulus
N015_RS07545	COG0583	DNA-binding transcription factor activity
N015_RS07560	COG4807	Protein conserved in bacteria
N015_RS07565	COG1187	pseudouridine synthase activity
N015_RS07575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N015_RS07590	COG3158	transport of potassium into the cell
N015_RS07615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N015_RS07625	COG0442	prolyl-tRNA aminoacylation
N015_RS07640	COG2900	Belongs to the SlyX family
N015_RS07650	COG0783	Belongs to the Dps family
N015_RS07660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N015_RS07665	COG0217	transcriptional regulatory protein
N015_RS07670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N015_RS07675	COG0632	four-way junction helicase activity
N015_RS07680	COG2255	four-way junction helicase activity
N015_RS07685	COG0824	Thioesterase
N015_RS07705	COG0823	Involved in the tonB-independent uptake of proteins
N015_RS07710	COG2885	chlorophyll binding
N015_RS07715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
N015_RS07720	COG0602	queuosine metabolic process
N015_RS07725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N015_RS07745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N015_RS07750	COG0589	response to stress
N015_RS07755	COG0659	secondary active sulfate transmembrane transporter activity
N015_RS07765	COG2202	Pas domain
N015_RS07765	COG2205	protein histidine kinase activity
N015_RS07775	COG2197	response regulator
N015_RS07810	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N015_RS07830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N015_RS07835	COG4783	chaperone-mediated protein folding
N015_RS07840	COG0425	Belongs to the sulfur carrier protein TusA family
N015_RS07850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N015_RS07860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N015_RS07865	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
N015_RS07870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N015_RS07875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N015_RS07890	COG4214	carbohydrate transport
N015_RS07895	COG1129	ABC transporter
N015_RS07900	COG4213	ABC transporter substrate-binding protein
N015_RS07905	COG2115	Belongs to the xylose isomerase family
N015_RS07910	COG2207	Transcriptional regulator
N015_RS07910	COG1609	Transcriptional regulator
N015_RS07930	COG0281	malic enzyme
N015_RS07935	COG2194	sulfuric ester hydrolase activity
N015_RS07945	COG3100	YcgL domain-containing protein
N015_RS07960	COG2983	Belongs to the UPF0260 family
N015_RS07975	COG3667	copper resistance
N015_RS07980	COG2132	Multicopper oxidase
N015_RS07985	COG1403	HNH endonuclease
N015_RS07995	COG1770	oligopeptidase
N015_RS08005	COG0121	glutamine amidotransferase
N015_RS08015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N015_RS08030	COG0542	response to heat
N015_RS08040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N015_RS08050	COG2205	protein histidine kinase activity
N015_RS08070	COG0385	Bile acid
N015_RS08075	COG2974	May be involved in recombination
N015_RS08095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N015_RS08130	COG3706	GGDEF domain
N015_RS08130	COG4251	negative regulation of phosphorylation
N015_RS08130	COG2203	Gaf domain
N015_RS08130	COG5001	Diguanylate cyclase
N015_RS08180	COG1362	aminopeptidase activity
N015_RS08185	COG0564	pseudouridine synthase activity
N015_RS08190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N015_RS08195	COG2894	cell division
N015_RS08200	COG0850	regulation of cytokinetic process
N015_RS08205	COG1560	Kdo2-lipid A biosynthetic process
N015_RS08220	COG2853	Lipoprotein
N015_RS08235	COG3162	membrane
N015_RS08240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N015_RS08260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N015_RS08265	COG3089	Belongs to the UPF0270 family
N015_RS08270	COG1363	Peptidase, m42
N015_RS08280	COG0367	asparagine synthase
N015_RS08285	COG0582	viral genome integration into host DNA
N015_RS08380	COG1484	DNA-dependent DNA replication
N015_RS08385	COG0305	Participates in initiation and elongation during chromosome replication
N015_RS08455	COG4695	Portal protein
N015_RS08460	COG0740	serine-type endopeptidase activity
N015_RS08575	COG4181	ATPase activity
N015_RS08580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS08580	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N015_RS08585	COG2326	polyphosphate kinase activity
N015_RS08595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS08615	COG2832	Protein of unknown function (DUF454)
N015_RS08645	COG1960	acyl-CoA dehydrogenase activity
N015_RS08650	COG0625	glutathione transferase activity
N015_RS08655	COG1131	(ABC) transporter
N015_RS08660	COG0842	Transport permease protein
N015_RS08670	COG0811	peptide transport
N015_RS08675	COG0848	biopolymer transport protein
N015_RS08680	COG1663	tetraacyldisaccharide 4'-kinase activity
N015_RS08685	COG2835	tetraacyldisaccharide 4'-kinase activity
N015_RS08690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N015_RS08695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N015_RS08700	COG1530	ribonuclease E activity
N015_RS08710	COG0546	phosphoglycolate phosphatase activity
N015_RS08715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N015_RS08715	COG0616	signal peptide processing
N015_RS08720	COG0424	maF-like protein
N015_RS08725	COG1399	metal-binding, possibly nucleic acid-binding protein
N015_RS08730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N015_RS08735	COG0416	fatty acid biosynthetic process
N015_RS08750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N015_RS08755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N015_RS08765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N015_RS08770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N015_RS08785	COG0084	hydrolase, TatD family'
N015_RS08825	COG0135	phosphoribosylanthranilate isomerase activity
N015_RS08830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N015_RS08835	COG0285	dihydrofolate synthase activity
N015_RS08845	COG1286	toxin biosynthetic process
N015_RS08885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N015_RS08905	COG1902	pentaerythritol trinitrate reductase activity
N015_RS08905	COG0446	pyridine nucleotide-disulphide oxidoreductase
N015_RS08920	COG2223	nitrite transmembrane transporter activity
N015_RS08935	COG3706	GGDEF domain
N015_RS08935	COG0745	RESPONSE REGULATOR receiver
N015_RS08940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N015_RS08945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N015_RS08950	COG0705	Rhomboid family
N015_RS08955	COG3139	Protein of unknown function (DUF1315)
N015_RS08965	COG0308	aminopeptidase N
N015_RS08995	COG3766	membrane
N015_RS09005	COG0754	glutathionylspermidine amidase activity
N015_RS09020	COG1609	Transcriptional regulator
N015_RS09045	COG4993	Dehydrogenase
N015_RS09050	COG2706	6-phosphogluconolactonase activity
N015_RS09070	COG0420	3'-5' exonuclease activity
N015_RS09085	COG2304	oxidoreductase activity
N015_RS09100	COG0714	Associated with various cellular activities
N015_RS09120	COG1971	Probably functions as a manganese efflux pump
N015_RS09130	COG0697	spore germination
N015_RS09135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N015_RS09155	COG1846	Transcriptional regulator
N015_RS09160	COG1566	PFAM secretion protein HlyD family protein
N015_RS09165	COG2814	Major facilitator Superfamily
N015_RS09170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N015_RS09180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N015_RS09185	COG0215	cysteine-tRNA ligase activity
N015_RS09190	COG3284	Transcriptional regulator
N015_RS09195	COG3842	ATPase activity
N015_RS09200	COG3842	ATPase activity
N015_RS09210	COG0395	ABC-type sugar transport system, permease component
N015_RS09225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N015_RS09245	COG0544	peptidyl-prolyl cis-trans isomerase activity
N015_RS09250	COG0740	serine-type endopeptidase activity
N015_RS09255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N015_RS09260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N015_RS09265	COG0776	regulation of translation
N015_RS09270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N015_RS09280	COG4172	Belongs to the ABC transporter superfamily
N015_RS09285	COG4239	(ABC) transporter, permease
N015_RS09290	COG4174	ABC transporter (Permease)
N015_RS09295	COG4166	transmembrane transport
N015_RS09300	COG4166	transmembrane transport
N015_RS09305	COG1388	LysM domain
N015_RS09305	COG0741	lytic transglycosylase activity
N015_RS09310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N015_RS09320	COG0328	RNA-DNA hybrid ribonuclease activity
N015_RS09325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N015_RS09340	COG0431	NADPH-dependent FMN reductase
N015_RS09350	COG1960	acyl-CoA dehydrogenase activity
N015_RS09355	COG1024	Enoyl-CoA hydratase
N015_RS09370	COG0306	phosphate transporter
N015_RS09380	COG0656	L-ascorbic acid biosynthetic process
N015_RS09385	COG0840	transmembrane signaling receptor activity
N015_RS09390	COG1309	transcriptional regulator
N015_RS09445	COG3046	protein related to deoxyribodipyrimidine photolyase
N015_RS09470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N015_RS09475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N015_RS09500	COG1802	Transcriptional regulator
N015_RS09505	COG1914	H( )-stimulated, divalent metal cation uptake system
N015_RS09510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N015_RS09515	COG4336	lyase activity
N015_RS09520	COG1984	allophanate hydrolase subunit 2
N015_RS09525	COG4770	biotin carboxylase activity
N015_RS09540	COG1538	Outer membrane efflux protein
N015_RS09560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N015_RS09585	COG1309	transcriptional regulator
N015_RS09655	COG3842	ATPase activity
N015_RS09660	COG0410	ABC transporter
N015_RS09675	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
N015_RS09680	COG2384	SAM-dependent methyltransferase
N015_RS09690	COG0583	DNA-binding transcription factor activity
N015_RS09710	COG2207	Transcriptional regulator
N015_RS09710	COG3708	Transcriptional regulator
N015_RS09730	COG0840	transmembrane signaling receptor activity
N015_RS09735	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N015_RS09740	COG1522	sequence-specific DNA binding
N015_RS09750	COG2354	Protein conserved in bacteria
N015_RS09765	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
N015_RS09770	COG4266	Belongs to the allantoicase family
N015_RS09815	COG2154	pterin-4-alpha-carbinolamine dehydratase
N015_RS09825	COG3283	Transcriptional regulator of aromatic amino acids metabolism
N015_RS09835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N015_RS09840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS09845	COG4215	(ABC) transporter
N015_RS09870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N015_RS09885	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS09890	COG3724	N-succinylarginine dihydrolase activity
N015_RS09900	COG2988	succinylglutamate desuccinylase activity
N015_RS09910	COG0402	S-adenosylhomocysteine deaminase activity
N015_RS09920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N015_RS09940	COG3115	cell septum assembly
N015_RS09945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N015_RS09965	COG0668	transmembrane transport
N015_RS09975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N015_RS09980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N015_RS09995	COG0251	oxidation-reduction process
N015_RS10005	COG0583	DNA-binding transcription factor activity
N015_RS10010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N015_RS10020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N015_RS10030	COG4133	protoheme IX ABC transporter activity
N015_RS10050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N015_RS10055	COG1138	Cytochrome C-type biogenesis protein
N015_RS10080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N015_RS10085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N015_RS10105	COG1289	transmembrane transporter activity
N015_RS10135	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
N015_RS10140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N015_RS10150	COG2837	iron assimilation
N015_RS10165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N015_RS10180	COG0659	secondary active sulfate transmembrane transporter activity
N015_RS10185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N015_RS10200	COG2223	nitrite transmembrane transporter activity
N015_RS10215	COG0583	DNA-binding transcription factor activity
N015_RS10230	COG0784	Response regulator, receiver
N015_RS10230	COG4191	Histidine kinase
N015_RS10295	COG4774	siderophore transport
N015_RS10325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N015_RS10335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N015_RS10345	COG3265	gluconokinase activity
N015_RS10360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N015_RS10365	COG3193	protein, possibly involved in utilization of glycolate and propanediol
N015_RS10370	COG0247	lactate metabolic process
N015_RS10375	COG0277	FAD linked oxidase domain protein
N015_RS10380	COG0277	FAD linked oxidase domain protein
N015_RS10385	COG2186	Transcriptional regulator
N015_RS10405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N015_RS10410	COG0179	Fumarylacetoacetate (FAA) hydrolase
N015_RS10415	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N015_RS10430	COG2807	transmembrane transport
N015_RS10455	COG4650	regulator
N015_RS10460	COG1690	Belongs to the RtcB family
N015_RS10465	COG3541	Predicted nucleotidyltransferase
N015_RS10470	COG0430	RNA-3'-phosphate cyclase activity
N015_RS10485	COG0583	DNA-binding transcription factor activity
N015_RS10495	COG0583	DNA-binding transcription factor activity
N015_RS10500	COG0728	peptidoglycan biosynthetic process
N015_RS10545	COG0662	Cupin 2, conserved barrel domain protein
N015_RS10545	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N015_RS10550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N015_RS10555	COG1597	lipid kinase activity
N015_RS10560	COG2197	response regulator
N015_RS10565	COG3851	Histidine kinase
N015_RS10580	COG3217	Mosc domain protein beta barrel domain protein
N015_RS10580	COG0633	Ferredoxin
N015_RS10585	COG0741	lytic transglycosylase activity
N015_RS10595	COG0589	response to stress
N015_RS10610	COG1250	3-hydroxyacyl-CoA dehydrogenase
N015_RS10610	COG1024	Enoyl-CoA hydratase
N015_RS10615	COG0183	Belongs to the thiolase family
N015_RS10645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N015_RS10660	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N015_RS10670	COG3568	Endonuclease Exonuclease Phosphatase
N015_RS10675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N015_RS10680	COG0392	lysyltransferase activity
N015_RS10690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N015_RS10700	COG3718	enzyme involved in inositol metabolism
N015_RS10715	COG3962	Belongs to the TPP enzyme family
N015_RS10720	COG0673	inositol 2-dehydrogenase activity
N015_RS10725	COG0673	inositol 2-dehydrogenase activity
N015_RS10735	COG1129	ABC transporter
N015_RS10740	COG4211	Belongs to the binding-protein-dependent transport system permease family
N015_RS10745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N015_RS10750	COG0840	transmembrane signaling receptor activity
N015_RS10770	COG1320	monovalent cation:proton antiporter activity
N015_RS10775	COG2212	antiporter activity
N015_RS10785	COG0651	ATP synthesis coupled electron transport
N015_RS10790	COG1006	Multisubunit Na H antiporter MnhC subunit
N015_RS10795	COG2111	Na H antiporter
N015_RS10795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N015_RS10825	COG3829	transcription factor binding
N015_RS10830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N015_RS10835	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N015_RS10850	COG0667	Aldo Keto reductase
N015_RS10855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N015_RS10860	COG0584	glycerophosphoryl diester phosphodiesterase
N015_RS10865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N015_RS10870	COG0504	CTP synthase activity
N015_RS10875	COG2329	Antibiotic biosynthesis monooxygenase
N015_RS10885	COG2031	fatty acid transporter
N015_RS10900	COG0583	DNA-binding transcription factor activity
N015_RS10915	COG0431	NADPH-dependent FMN reductase
N015_RS10925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N015_RS10970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N015_RS10995	COG1104	cysteine desulfurase activity
N015_RS11045	COG0720	synthase
N015_RS11060	COG0745	RESPONSE REGULATOR receiver
N015_RS11095	COG0713	ATP synthesis coupled electron transport
N015_RS11105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N015_RS11110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N015_RS11115	COG1034	ATP synthesis coupled electron transport
N015_RS11130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N015_RS11130	COG0649	NAD binding
N015_RS11135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N015_RS11140	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N015_RS11155	COG2153	protein acetylation
N015_RS11160	COG2850	peptidyl-arginine hydroxylation
N015_RS11170	COG2915	High frequency lysogenization protein hflD homolog
N015_RS11175	COG0482	sulfurtransferase activity
N015_RS11190	COG1278	Cold shock
N015_RS11195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N015_RS11200	COG0542	response to heat
N015_RS11205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N015_RS11210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N015_RS11215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N015_RS11220	COG1674	ftsk spoiiie
N015_RS11225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N015_RS11230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N015_RS11235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N015_RS11240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N015_RS11245	COG1648	precorrin-2 dehydrogenase activity
N015_RS11245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N015_RS11250	COG0435	Glutathione S-transferase
N015_RS11255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N015_RS11260	COG2920	part of a sulfur-relay system
N015_RS11310	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS11315	COG0583	DNA-binding transcription factor activity
N015_RS11330	COG1309	transcriptional regulator
N015_RS11345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N015_RS11350	COG1459	type II secretion system
N015_RS11355	COG2165	general secretion pathway protein
N015_RS11360	COG2165	general secretion pathway protein
N015_RS11375	COG3156	type II secretion system protein K
N015_RS11395	COG1450	Type ii and iii secretion system protein
N015_RS11405	COG2814	Major facilitator Superfamily
N015_RS11415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS11420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS11425	COG2267	carboxylic ester hydrolase activity
N015_RS11430	COG5002	protein histidine kinase activity
N015_RS11435	COG0745	RESPONSE REGULATOR receiver
N015_RS11440	COG2116	formate transmembrane transporter activity
N015_RS11450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N015_RS11480	COG3835	regulator
N015_RS11485	COG1929	Belongs to the glycerate kinase type-1 family
N015_RS11495	COG2942	2-epimerase
N015_RS11500	COG3180	Ammonia monooxygenase
N015_RS11505	COG0583	DNA-binding transcription factor activity
N015_RS11535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N015_RS11540	COG0573	inorganic phosphate transmembrane transporter activity
N015_RS11545	COG0581	inorganic phosphate transmembrane transporter activity
N015_RS11550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N015_RS11560	COG0596	Alpha beta hydrolase
N015_RS11575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N015_RS11580	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
N015_RS11585	COG3639	organic phosphonate transmembrane transporter activity
N015_RS11590	COG2188	Transcriptional regulator
N015_RS11595	COG3624	Phosphonate C-P lyase system protein PhnG
N015_RS11600	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
N015_RS11605	COG3626	phosphonate metabolism
N015_RS11610	COG3627	carbon phosphorus lyase activity
N015_RS11615	COG4107	phosphonate C-P lyase system protein PhnK
N015_RS11620	COG4778	phosphonate C-P lyase system protein PhnL
N015_RS11625	COG3454	Phosphonate metabolism
N015_RS11630	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
N015_RS11635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N015_RS11645	COG0679	Auxin Efflux Carrier
N015_RS11650	COG0154	amidase activity
N015_RS11665	COG4608	Belongs to the ABC transporter superfamily
N015_RS11675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N015_RS11680	COG0601	transmembrane transport
N015_RS11695	COG1469	GTP cyclohydrolase I activity
N015_RS11765	COG3591	Belongs to the peptidase S1B family
N015_RS11765	COG1864	DNA RNA non-specific endonuclease
N015_RS11770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N015_RS11775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N015_RS11780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N015_RS11790	COG0840	transmembrane signaling receptor activity
N015_RS11800	COG0251	oxidation-reduction process
N015_RS11805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N015_RS11815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N015_RS11815	COG2146	nitrite reductase [NAD(P)H] activity
N015_RS11820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N015_RS11820	COG2146	nitrite reductase [NAD(P)H] activity
N015_RS11835	COG0826	peptidase U32
N015_RS11840	COG1120	ATPase activity
N015_RS11845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N015_RS11860	COG0406	alpha-ribazole phosphatase activity
N015_RS11880	COG5002	protein histidine kinase activity
N015_RS11880	COG5001	Diguanylate cyclase
N015_RS11880	COG3447	MASE1 domain protein
N015_RS11890	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
N015_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
N015_RS11955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N015_RS11965	COG0438	transferase activity, transferring glycosyl groups
N015_RS11985	COG2814	Major facilitator Superfamily
N015_RS11990	COG1741	Belongs to the pirin family
N015_RS11995	COG0583	DNA-binding transcription factor activity
N015_RS12015	COG3008	intermembrane lipid transfer
N015_RS12020	COG2995	paraquat-inducible protein a
N015_RS12025	COG2995	paraquat-inducible protein a
N015_RS12060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N015_RS12070	COG0183	Belongs to the thiolase family
N015_RS12075	COG1024	Enoyl-CoA hydratase
N015_RS12085	COG0217	transcriptional regulatory protein
N015_RS12105	COG2866	Carboxypeptidase
N015_RS12110	COG1595	DNA-templated transcription, initiation
N015_RS12115	COG1522	sequence-specific DNA binding
N015_RS12185	COG1968	undecaprenyl-diphosphatase activity
N015_RS12200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N015_RS12205	COG0583	DNA-binding transcription factor activity
N015_RS12210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N015_RS12255	COG1640	4-alpha-glucanotransferase
N015_RS12260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N015_RS12265	COG0297	glycogen (starch) synthase activity
N015_RS12280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N015_RS12285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N015_RS12290	COG0561	phosphatase activity
N015_RS12295	COG3387	PFAM Glycoside hydrolase 15-related
N015_RS12300	COG3145	DNA-N1-methyladenine dioxygenase activity
N015_RS12350	COG0450	alkyl hydroperoxide reductase
N015_RS12355	COG3634	alkyl hydroperoxide reductase activity
N015_RS12395	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS12435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N015_RS12450	COG2207	Transcriptional regulator
N015_RS12455	COG0583	DNA-binding transcription factor activity
N015_RS12460	COG1902	pentaerythritol trinitrate reductase activity
N015_RS12485	COG2816	NAD+ diphosphatase activity
N015_RS12490	COG1902	pentaerythritol trinitrate reductase activity
N015_RS12500	COG1309	transcriptional regulator
N015_RS12525	COG1802	Transcriptional regulator
N015_RS12530	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS12535	COG3246	L-lysine catabolic process to acetate
N015_RS12540	COG3386	PFAM SMP-30 Gluconolaconase
N015_RS12555	COG1024	Enoyl-CoA hydratase
N015_RS12560	COG0045	succinate-CoA ligase (ADP-forming) activity
N015_RS12560	COG1042	CoA-binding domain protein
N015_RS12560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N015_RS12565	COG1116	anion transmembrane transporter activity
N015_RS12570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N015_RS12575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N015_RS12585	COG1024	Enoyl-CoA hydratase
N015_RS12585	COG1250	3-hydroxyacyl-CoA dehydrogenase
N015_RS12600	COG0596	Alpha beta hydrolase
N015_RS12610	COG3386	PFAM SMP-30 Gluconolaconase
N015_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS12630	COG1301	dicarboxylic acid transport
N015_RS12635	COG0583	DNA-binding transcription factor activity
N015_RS12690	COG0604	alcohol dehydrogenase
N015_RS12690	COG3321	synthase
N015_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS12700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N015_RS12705	COG1199	ATP-dependent helicase activity
N015_RS12715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N015_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS12730	COG2610	gluconate transmembrane transporter activity
N015_RS12735	COG3290	protein histidine kinase activity
N015_RS12735	COG3829	transcription factor binding
N015_RS12740	COG4172	Belongs to the ABC transporter superfamily
N015_RS12745	COG4239	(ABC) transporter, permease
N015_RS12750	COG4174	ABC transporter (Permease)
N015_RS12755	COG4166	transmembrane transport
N015_RS12760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N015_RS12765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N015_RS12785	COG0322	excinuclease ABC activity
N015_RS12840	COG2814	Major facilitator Superfamily
N015_RS12890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N015_RS12905	COG0583	DNA-binding transcription factor activity
N015_RS12910	COG1902	pentaerythritol trinitrate reductase activity
N015_RS12920	COG0243	molybdopterin cofactor binding
N015_RS12935	COG1129	ABC transporter
N015_RS12940	COG1172	Belongs to the binding-protein-dependent transport system permease family
N015_RS12945	COG1172	Belongs to the binding-protein-dependent transport system permease family
N015_RS12980	COG4325	translation initiation factor activity
N015_RS13220	COG1484	DNA-dependent DNA replication
N015_RS13375	COG3617	BRO family, N-terminal domain
N015_RS13420	COG3179	chitinase
N015_RS13450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N015_RS13470	COG1309	transcriptional regulator
N015_RS13475	COG0604	alcohol dehydrogenase
N015_RS13490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N015_RS13505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N015_RS13520	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N015_RS13535	COG1280	lysine exporter protein (LysE YggA)
N015_RS13550	COG4977	sequence-specific DNA binding
N015_RS13595	COG2814	Major facilitator Superfamily
N015_RS13610	COG1024	Enoyl-CoA hydratase
N015_RS13615	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS13625	COG0183	Belongs to the thiolase family
N015_RS13630	COG1960	acyl-CoA dehydrogenase activity
N015_RS13645	COG0251	oxidation-reduction process
N015_RS13660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N015_RS13670	COG1984	allophanate hydrolase subunit 2
N015_RS13700	COG4948	Mandelate Racemase Muconate Lactonizing
N015_RS13710	COG0583	DNA-binding transcription factor activity
N015_RS13730	COG5001	Diguanylate cyclase
N015_RS13750	COG0583	DNA-binding transcription factor activity
N015_RS13760	COG1917	Cupin 2, conserved barrel domain protein
N015_RS13760	COG1396	sequence-specific DNA binding
N015_RS13770	COG0784	Response regulator, receiver
N015_RS13770	COG4191	Histidine kinase
N015_RS13785	COG1082	Xylose isomerase domain protein TIM barrel
N015_RS13790	COG1609	Transcriptional regulator
N015_RS13825	COG0529	Catalyzes the synthesis of activated sulfate
N015_RS13890	COG3706	GGDEF domain
N015_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS13905	COG2207	Transcriptional regulator
N015_RS13915	COG0840	transmembrane signaling receptor activity
N015_RS13920	COG0531	amino acid
N015_RS13925	COG1982	Orn Lys Arg decarboxylase major
N015_RS13940	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
N015_RS13945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N015_RS13950	COG0589	response to stress
N015_RS13990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N015_RS14010	COG1126	abc transporter atp-binding protein
N015_RS14095	COG2814	Major facilitator Superfamily
N015_RS14105	COG4774	siderophore transport
N015_RS14110	COG3712	iron ion homeostasis
N015_RS14115	COG1595	DNA-templated transcription, initiation
N015_RS14125	COG0577	efflux transmembrane transporter activity
N015_RS14125	COG1136	(ABC) transporter
N015_RS14130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS14150	COG2390	Transcriptional regulator
N015_RS14155	COG0698	ribose 5-phosphate isomerase
N015_RS14160	COG1129	ABC transporter
N015_RS14165	COG1172	Belongs to the binding-protein-dependent transport system permease family
N015_RS14170	COG1879	ABC-type sugar transport system periplasmic component
N015_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS14180	COG1063	alcohol dehydrogenase
N015_RS14185	COG2376	Dihydroxyacetone kinase
N015_RS14195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N015_RS14210	COG0747	negative chemotaxis
N015_RS14220	COG0444	Belongs to the ABC transporter superfamily
N015_RS14230	COG0601	transmembrane transport
N015_RS14235	COG2072	flavoprotein involved in K transport
N015_RS14250	COG3706	GGDEF domain
N015_RS14250	COG0745	RESPONSE REGULATOR receiver
N015_RS14260	COG0277	FAD linked oxidase domain protein
N015_RS14260	COG0247	lactate metabolic process
N015_RS14265	COG0583	DNA-binding transcription factor activity
N015_RS14270	COG0583	DNA-binding transcription factor activity
N015_RS14280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
N015_RS14295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N015_RS14300	COG0598	Magnesium transport protein CorA
N015_RS14310	COG0587	DNA-directed DNA polymerase activity
N015_RS14325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N015_RS14330	COG0667	Aldo Keto reductase
N015_RS14345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N015_RS14350	COG1116	anion transmembrane transporter activity
N015_RS14365	COG0210	DNA helicase
N015_RS14370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N015_RS14390	COG1126	abc transporter atp-binding protein
N015_RS14395	COG0765	amino acid transport
N015_RS14400	COG0765	amino acid transport
N015_RS14445	COG0488	(ABC) transporter
N015_RS14450	COG2706	6-phosphogluconolactonase activity
N015_RS14455	COG2814	Major facilitator Superfamily
N015_RS14465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N015_RS14470	COG0366	Alpha amylase catalytic
N015_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS14490	COG1538	Outer membrane efflux protein
N015_RS14495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N015_RS14525	COG0729	surface antigen
N015_RS14535	COG0708	Exodeoxyribonuclease III
N015_RS14540	COG2885	chlorophyll binding
N015_RS14545	COG1960	acyl-CoA dehydrogenase activity
N015_RS14555	COG0789	Transcriptional regulator
N015_RS14565	COG1960	acyl-CoA dehydrogenase activity
N015_RS14570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N015_RS14575	COG1024	Enoyl-CoA hydratase
N015_RS14585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N015_RS14585	COG0316	Belongs to the HesB IscA family
N015_RS14590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N015_RS14610	COG1879	ABC-type sugar transport system periplasmic component
N015_RS14615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N015_RS14625	COG0616	signal peptide processing
N015_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS14660	COG2816	NAD+ diphosphatase activity
N015_RS14665	COG1024	Enoyl-CoA hydratase
N015_RS14670	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N015_RS14685	COG5002	protein histidine kinase activity
N015_RS14685	COG0784	Response regulator, receiver
N015_RS14685	COG2205	protein histidine kinase activity
N015_RS14695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N015_RS14705	COG0745	RESPONSE REGULATOR receiver
N015_RS14730	COG1175	transmembrane transport
N015_RS14745	COG0246	Mannitol dehydrogenase
N015_RS14750	COG1070	Carbohydrate kinase
N015_RS14770	COG1064	alcohol dehydrogenase
N015_RS14775	COG0494	nUDIX hydrolase
N015_RS14790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS14805	COG1253	flavin adenine dinucleotide binding
N015_RS14815	COG0583	DNA-binding transcription factor activity
N015_RS14830	COG3132	Protein of unknown function, DUF480
N015_RS14835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N015_RS14855	COG1686	Belongs to the peptidase S11 family
N015_RS14865	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS14880	COG2267	carboxylic ester hydrolase activity
N015_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS14890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N015_RS14905	COG0456	acetyltransferase
N015_RS14915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N015_RS14925	COG1176	ABC-type spermidine putrescine transport system, permease component I
N015_RS14935	COG3842	ATPase activity
N015_RS14940	COG0583	DNA-binding transcription factor activity
N015_RS14950	COG0583	DNA-binding transcription factor activity
N015_RS14955	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS14960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N015_RS14970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N015_RS14975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N015_RS14980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N015_RS14985	COG2080	2 iron, 2 sulfur cluster binding
N015_RS14990	COG0579	oxidoreductase
N015_RS15030	COG3713	MltA-interacting MipA family protein
N015_RS15035	COG0745	RESPONSE REGULATOR receiver
N015_RS15040	COG5002	protein histidine kinase activity
N015_RS15045	COG1172	Belongs to the binding-protein-dependent transport system permease family
N015_RS15050	COG1129	ABC transporter
N015_RS15055	COG1879	ABC-type sugar transport system periplasmic component
N015_RS15060	COG3386	PFAM SMP-30 Gluconolaconase
N015_RS15065	COG2186	Transcriptional regulator
N015_RS15080	COG0803	Belongs to the bacterial solute-binding protein 9 family
N015_RS15090	COG1121	(ABC) transporter
N015_RS15105	COG0384	phenazine biosynthesis protein PhzF
N015_RS15115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N015_RS15125	COG0417	DNA replication proofreading
N015_RS15130	COG3300	MHYT domain
N015_RS15130	COG5001	Diguanylate cyclase
N015_RS15135	COG0517	IMP dehydrogenase activity
N015_RS15145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N015_RS15155	COG0840	transmembrane signaling receptor activity
N015_RS15170	COG2175	clavaminate synthase activity
N015_RS15215	COG2204	response regulator
N015_RS15270	COG1253	flavin adenine dinucleotide binding
N015_RS15305	COG0116	Belongs to the methyltransferase superfamily
N015_RS15305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N015_RS15320	COG1414	Transcriptional regulator
N015_RS15325	COG3842	ATPase activity
N015_RS15330	COG1176	ABC-type spermidine putrescine transport system, permease component I
N015_RS15335	COG1177	transmembrane transport
N015_RS15365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N015_RS15385	COG1335	isochorismatase
N015_RS15390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N015_RS15415	COG0028	Belongs to the TPP enzyme family
N015_RS15420	COG0768	penicillin binding
N015_RS15425	COG1733	regulation of RNA biosynthetic process
N015_RS15430	COG0702	epimerase
N015_RS15445	COG1280	lysine exporter protein (LysE YggA)
N015_RS15470	COG0477	Major facilitator Superfamily
N015_RS15480	COG2271	Major facilitator Superfamily
N015_RS15490	COG3604	Transcriptional regulator
N015_RS15495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N015_RS15495	COG0546	phosphoglycolate phosphatase activity
N015_RS15520	COG3387	PFAM Glycoside hydrolase 15-related
N015_RS15530	COG0667	Aldo Keto reductase
N015_RS15550	COG2066	Belongs to the glutaminase family
N015_RS15560	COG0235	Class ii aldolase
N015_RS15605	COG1999	signal sequence binding
N015_RS15615	COG3706	GGDEF domain
N015_RS15625	COG1238	metal cluster binding
N015_RS15635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N015_RS15640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N015_RS15645	COG0004	ammonium transporteR
N015_RS15650	COG0069	glutamate synthase activity
N015_RS15655	COG2218	PFAM glutamate synthase alpha subunit domain protein
N015_RS15660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N015_RS15680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N015_RS15695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N015_RS15695	COG0446	pyridine nucleotide-disulphide oxidoreductase
N015_RS15710	COG0840	transmembrane signaling receptor activity
N015_RS15715	COG0583	DNA-binding transcription factor activity
N015_RS15765	COG2207	Transcriptional regulator
N015_RS15770	COG1335	isochorismatase
N015_RS15780	COG0829	nickel cation binding
N015_RS15785	COG1959	2 iron, 2 sulfur cluster binding
N015_RS15790	COG0174	glutamine synthetase
N015_RS15795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N015_RS15820	COG0765	amino acid transport
N015_RS15825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS15855	COG0776	regulation of translation
N015_RS15860	COG0072	phenylalanine-tRNA ligase activity
N015_RS15865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N015_RS15870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N015_RS15875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N015_RS15880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N015_RS15885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N015_RS15895	COG1278	Cold shock
N015_RS15915	COG1869	D-ribose catabolic process
N015_RS15920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N015_RS15925	COG1609	Transcriptional regulator
N015_RS15930	COG1172	Belongs to the binding-protein-dependent transport system permease family
N015_RS15935	COG1129	ABC transporter
N015_RS15940	COG1879	ABC-type sugar transport system periplasmic component
N015_RS15970	COG0024	Methionine aminopeptidase
N015_RS16040	COG0521	Mo-molybdopterin cofactor biosynthetic process
N015_RS16045	COG0746	molybdenum cofactor guanylyltransferase activity
N015_RS16055	COG0564	pseudouridine synthase activity
N015_RS16060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N015_RS16065	COG1309	transcriptional regulator
N015_RS16075	COG2271	Major facilitator Superfamily
N015_RS16090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N015_RS16105	COG3485	protocatechuate 3,4-dioxygenase
N015_RS16110	COG3485	protocatechuate 3,4-dioxygenase
N015_RS16115	COG0583	DNA-binding transcription factor activity
N015_RS16130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N015_RS16165	COG2197	response regulator
N015_RS16275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N015_RS16345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS16345	COG2205	protein histidine kinase activity
N015_RS16350	COG3171	Protein conserved in bacteria
N015_RS16360	COG0745	RESPONSE REGULATOR receiver
N015_RS16360	COG3706	GGDEF domain
N015_RS16365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N015_RS16365	COG0116	Belongs to the methyltransferase superfamily
N015_RS16370	COG3130	regulation of translation
N015_RS16375	COG0167	dihydroorotate dehydrogenase activity
N015_RS16380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N015_RS16380	COG1116	anion transmembrane transporter activity
N015_RS16385	COG3707	response regulator
N015_RS16395	COG2223	nitrite transmembrane transporter activity
N015_RS16400	COG0515	serine threonine protein kinase
N015_RS16400	COG2815	serine threonine protein kinase
N015_RS16405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N015_RS16410	COG0243	molybdopterin cofactor binding
N015_RS16415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N015_RS16435	COG0668	transmembrane transport
N015_RS16450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N015_RS16465	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N015_RS16470	COG2828	Protein conserved in bacteria
N015_RS16480	COG0372	Belongs to the citrate synthase family
N015_RS16490	COG1802	Transcriptional regulator
N015_RS16495	COG4067	protein conserved in archaea
N015_RS16495	COG0189	ligase activity
N015_RS16515	COG0560	Phosphoserine phosphatase
N015_RS16530	COG0589	response to stress
N015_RS16535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N015_RS16545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N015_RS16560	COG1376	ErfK ybiS ycfS ynhG family protein
N015_RS16575	COG4181	ATPase activity
N015_RS16580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N015_RS16585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N015_RS16615	COG2259	Doxx family
N015_RS16620	COG0741	lytic transglycosylase activity
N015_RS16625	COG0084	hydrolase, TatD family'
N015_RS16660	COG0714	Associated with various cellular activities
N015_RS16685	COG0745	RESPONSE REGULATOR receiver
N015_RS16690	COG2205	protein histidine kinase activity
N015_RS16695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N015_RS16705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N015_RS16720	COG3209	COG3209 Rhs family protein
N015_RS16755	COG3121	Chaperone
N015_RS16760	COG3188	usher protein
N015_RS16790	COG2205	protein histidine kinase activity
N015_RS16800	COG0628	permease
N015_RS16825	COG2062	phosphohistidine phosphatase, SixA
N015_RS16835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N015_RS16840	COG0784	Response regulator, receiver
N015_RS16840	COG2205	protein histidine kinase activity
N015_RS16840	COG5002	protein histidine kinase activity
N015_RS16845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N015_RS16855	COG1741	Belongs to the pirin family
N015_RS16865	COG0326	Molecular chaperone. Has ATPase activity
N015_RS16890	COG0045	succinate-CoA ligase (ADP-forming) activity
N015_RS16895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N015_RS16910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N015_RS16915	COG1053	succinate dehydrogenase
N015_RS16920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N015_RS16925	COG2009	succinate dehydrogenase
N015_RS16950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N015_RS16955	COG2885	chlorophyll binding
N015_RS16955	COG3047	cAMP biosynthetic process
N015_RS16985	COG2207	Transcriptional regulator
N015_RS16990	COG1064	alcohol dehydrogenase
N015_RS16995	COG1414	Transcriptional regulator
N015_RS17000	COG2271	Major facilitator Superfamily
N015_RS17005	COG4948	Mandelate Racemase Muconate Lactonizing
N015_RS17010	COG0800	Aldolase
N015_RS17015	COG3734	2-keto-3-deoxy-galactonokinase
N015_RS17025	COG0473	3-isopropylmalate dehydrogenase activity
N015_RS17030	COG2226	methyltransferase
N015_RS17035	COG0066	3-isopropylmalate dehydratase activity
N015_RS17040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N015_RS17060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N015_RS17090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N015_RS17095	COG0556	nucleotide-excision repair
N015_RS17110	COG2366	antibiotic biosynthetic process
N015_RS17115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS17120	COG1136	(ABC) transporter
N015_RS17120	COG0577	efflux transmembrane transporter activity
N015_RS17215	COG1121	(ABC) transporter
N015_RS17220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N015_RS17265	COG2197	response regulator
N015_RS17270	COG2205	protein histidine kinase activity
N015_RS17270	COG0784	Response regulator, receiver
N015_RS17285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N015_RS17345	COG0640	Transcriptional regulator
N015_RS17355	COG0431	NADPH-dependent FMN reductase
N015_RS17370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N015_RS17395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N015_RS17405	COG2204	response regulator
N015_RS17415	COG2853	Lipoprotein
N015_RS17430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N015_RS17430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N015_RS17445	COG4591	ABC-type transport system involved in lipoprotein release permease component
N015_RS17450	COG1136	(ABC) transporter
N015_RS17455	COG4591	ABC-type transport system involved in lipoprotein release permease component
N015_RS17465	COG0584	glycerophosphoryl diester phosphodiesterase
N015_RS17470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N015_RS17475	COG1477	protein flavinylation
N015_RS17490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N015_RS17500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N015_RS17515	COG1335	isochorismatase
N015_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS17565	COG0598	Magnesium transport protein CorA
N015_RS17570	COG0519	Catalyzes the synthesis of GMP from XMP
N015_RS17570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N015_RS17580	COG1305	Transglutaminase-like
N015_RS17590	COG2308	Evidence 4 Homologs of previously reported genes of
N015_RS17605	COG1368	sulfuric ester hydrolase activity
N015_RS17610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N015_RS17640	COG2197	response regulator
N015_RS17645	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
N015_RS17650	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
N015_RS17655	COG0235	Class ii aldolase
N015_RS17665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N015_RS17695	COG2840	Smr protein MutS2
N015_RS17705	COG0302	gtp cyclohydrolase
N015_RS17720	COG0625	glutathione transferase activity
N015_RS17725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N015_RS17735	COG3135	benzoate transporter
N015_RS17740	COG0840	transmembrane signaling receptor activity
N015_RS17745	COG1619	proteins homologs of microcin C7 resistance protein MccF
N015_RS17750	COG2130	NADP-dependent
N015_RS17755	COG0284	orotidine-5'-phosphate decarboxylase activity
N015_RS17780	COG3123	guanosine phosphorylase activity
N015_RS17785	COG1132	(ABC) transporter
N015_RS17790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N015_RS17795	COG0425	Belongs to the sulfur carrier protein TusA family
N015_RS17800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
N015_RS17815	COG0840	transmembrane signaling receptor activity
N015_RS17855	COG3278	Belongs to the heme-copper respiratory oxidase family
N015_RS17870	COG2010	Cytochrome c
N015_RS17875	COG0348	domain, Protein
N015_RS17910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N015_RS17915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N015_RS17925	COG0835	chemotaxis
N015_RS17935	COG1192	Involved in chromosome partitioning
N015_RS17945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N015_RS17950	COG2201	protein-glutamate methylesterase activity
N015_RS17955	COG0643	Histidine kinase
N015_RS17955	COG2198	Histidine kinase
N015_RS17960	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N015_RS17975	COG0455	bacterial-type flagellum organization
N015_RS17990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N015_RS18000	COG1987	bacterial-type flagellum assembly
N015_RS18040	COG0745	RESPONSE REGULATOR receiver
N015_RS18075	COG1677	Flagellar hook-basal body complex protein FliE
N015_RS18085	COG3852	Histidine kinase
N015_RS18090	COG2204	response regulator
N015_RS18105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N015_RS18120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N015_RS18125	COG0438	transferase activity, transferring glycosyl groups
N015_RS18125	COG1216	Glycosyl transferase, family 2
N015_RS18150	COG1706	bacterial-type flagellum-dependent cell motility
N015_RS18155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N015_RS18160	COG4786	Flagellar basal body rod
N015_RS18165	COG4787	bacterial-type flagellum-dependent cell motility
N015_RS18180	COG1749	Flagellar hook protein flgE
N015_RS18185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N015_RS18190	COG1558	bacterial-type flagellum-dependent cell motility
N015_RS18200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N015_RS18205	COG0835	chemotaxis
N015_RS18205	COG0784	Response regulator, receiver
N015_RS18225	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
N015_RS18230	COG0477	Major facilitator Superfamily
N015_RS18250	COG1216	Glycosyl transferase, family 2
N015_RS18250	COG0438	transferase activity, transferring glycosyl groups
N015_RS18255	COG0110	maltose O-acetyltransferase activity
N015_RS18265	COG0745	RESPONSE REGULATOR receiver
N015_RS18270	COG4991	sh3 domain protein
N015_RS18275	COG1611	Belongs to the LOG family
N015_RS18290	COG2271	Major facilitator Superfamily
N015_RS18295	COG3501	Rhs element vgr protein
N015_RS18310	COG4251	negative regulation of phosphorylation
N015_RS18355	COG0745	RESPONSE REGULATOR receiver
N015_RS18365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS18370	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS18375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N015_RS18380	COG5383	Protein conserved in bacteria
N015_RS18390	COG0583	DNA-binding transcription factor activity
N015_RS18395	COG1760	l-serine dehydratase
N015_RS18400	COG1473	amidohydrolase
N015_RS18420	COG1045	serine acetyltransferase
N015_RS18425	COG0583	DNA-binding transcription factor activity
N015_RS18440	COG1953	Uracil, thiamine, allantoin
N015_RS18450	COG2851	Citrate transporter
N015_RS18455	COG1301	dicarboxylic acid transport
N015_RS18460	COG2828	Protein conserved in bacteria
N015_RS18465	COG0583	DNA-binding transcription factor activity
N015_RS18480	COG4191	Histidine kinase
N015_RS18480	COG0784	Response regulator, receiver
N015_RS18490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N015_RS18495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS18500	COG0745	RESPONSE REGULATOR receiver
N015_RS18505	COG2205	protein histidine kinase activity
N015_RS18520	COG4608	Belongs to the ABC transporter superfamily
N015_RS18525	COG0444	Belongs to the ABC transporter superfamily
N015_RS18530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N015_RS18535	COG0601	transmembrane transport
N015_RS18540	COG0747	negative chemotaxis
N015_RS18545	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
N015_RS18550	COG1737	Transcriptional regulator
N015_RS18580	COG2356	endonuclease I
N015_RS18585	COG0154	amidase activity
N015_RS18590	COG1132	(ABC) transporter
N015_RS18600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N015_RS18610	COG0864	Transcriptional regulator
N015_RS18615	COG0747	negative chemotaxis
N015_RS18620	COG0601	transmembrane transport
N015_RS18625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N015_RS18630	COG0444	Belongs to the ABC transporter superfamily
N015_RS18635	COG1124	(ABC) transporter
N015_RS18640	COG0519	Catalyzes the synthesis of GMP from XMP
N015_RS18820	COG2239	Acts as a magnesium transporter
N015_RS18845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N015_RS18850	COG0527	aspartate kinase activity
N015_RS18855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N015_RS18860	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N015_RS18865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N015_RS18875	COG1113	amino acid transport
N015_RS18890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N015_RS18900	COG0009	L-threonylcarbamoyladenylate synthase
N015_RS18905	COG0613	PHP domain protein
N015_RS18910	COG2917	probably involved in intracellular septation
N015_RS18915	COG2350	Protein conserved in bacteria
N015_RS18925	COG0745	RESPONSE REGULATOR receiver
N015_RS18935	COG0642	Histidine kinase
N015_RS18940	COG0778	Nitroreductase
N015_RS18945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N015_RS18970	COG1116	anion transmembrane transporter activity
N015_RS18975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N015_RS18985	COG0583	DNA-binding transcription factor activity
N015_RS19000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N015_RS19005	COG1960	acyl-CoA dehydrogenase activity
N015_RS19010	COG0583	DNA-binding transcription factor activity
N015_RS19040	COG1741	Belongs to the pirin family
N015_RS19070	COG1956	GAF domain-containing protein
N015_RS19075	COG2255	four-way junction helicase activity
N015_RS19080	COG0784	Response regulator, receiver
N015_RS19080	COG5002	protein histidine kinase activity
N015_RS19080	COG2205	protein histidine kinase activity
N015_RS19085	COG0386	Belongs to the glutathione peroxidase family
N015_RS19090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N015_RS19095	COG0436	Aminotransferase
N015_RS19100	COG0501	Belongs to the peptidase M48B family
N015_RS19105	COG0500	methyltransferase
N015_RS19110	COG3384	dioxygenase
N015_RS19125	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N015_RS19130	COG3214	Protein conserved in bacteria
N015_RS19135	COG5457	Domain of unknown function (DUF1127)
N015_RS19140	COG0583	DNA-binding transcription factor activity
N015_RS19150	COG1846	Transcriptional regulator
N015_RS19160	COG1764	response to oxidative stress
N015_RS19170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N015_RS19200	COG0814	amino acid
N015_RS19205	COG1309	transcriptional regulator
N015_RS19210	COG1555	photosystem II stabilization
N015_RS19220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N015_RS19230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N015_RS19240	COG0776	regulation of translation
N015_RS19250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N015_RS19255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N015_RS19265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N015_RS19275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N015_RS19280	COG0402	S-adenosylhomocysteine deaminase activity
N015_RS19285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N015_RS19290	COG0546	phosphoglycolate phosphatase activity
N015_RS19295	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS19300	COG3706	GGDEF domain
N015_RS19310	COG5001	Diguanylate cyclase
N015_RS19310	COG5002	protein histidine kinase activity
N015_RS19330	COG0271	Belongs to the BolA IbaG family
N015_RS19340	COG0114	fumarate hydratase activity
N015_RS19350	COG0697	spore germination
N015_RS19410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N015_RS19415	COG0406	alpha-ribazole phosphatase activity
N015_RS19420	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N015_RS19430	COG1492	cobalamin metabolic process
N015_RS19440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N015_RS19445	COG0778	Nitroreductase
N015_RS19450	COG1797	cobyrinic acid a,c-diamide synthase activity
N015_RS19465	COG0791	NLP P60 protein
N015_RS19470	COG0791	NLP P60 protein
N015_RS19475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N015_RS19480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N015_RS19485	COG0628	permease
N015_RS19495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N015_RS19500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N015_RS19520	COG3956	TIGRFAM MazG family protein
N015_RS19525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N015_RS19530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N015_RS19545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N015_RS19560	COG3118	belongs to the thioredoxin family
N015_RS19565	COG1393	Belongs to the ArsC family
N015_RS19580	COG2818	Glycosylase
N015_RS19585	COG0037	tRNA processing
N015_RS19595	COG3091	SprT-like family
N015_RS19600	COG1301	dicarboxylic acid transport
N015_RS19605	COG2205	protein histidine kinase activity
N015_RS19610	COG0745	RESPONSE REGULATOR receiver
N015_RS19635	COG2205	protein histidine kinase activity
N015_RS19640	COG0745	RESPONSE REGULATOR receiver
N015_RS19655	COG2184	nucleotidyltransferase activity
N015_RS19660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N015_RS19665	COG1403	HNH endonuclease
N015_RS19710	COG0583	DNA-binding transcription factor activity
N015_RS19735	COG0840	transmembrane signaling receptor activity
N015_RS19750	COG0583	DNA-binding transcription factor activity
N015_RS19760	COG3706	GGDEF domain
N015_RS19775	COG2197	response regulator
N015_RS19780	COG0477	Major facilitator Superfamily
N015_RS19795	COG2133	pyrroloquinoline quinone binding
N015_RS19810	COG2205	protein histidine kinase activity
N015_RS19815	COG2267	carboxylic ester hydrolase activity
N015_RS19825	COG0590	tRNA wobble adenosine to inosine editing
N015_RS19850	COG0242	peptide deformylase activity
N015_RS19855	COG1295	ribonuclease BN
N015_RS19875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N015_RS19880	COG2996	Protein conserved in bacteria
N015_RS19915	COG0513	Belongs to the DEAD box helicase family
N015_RS19950	COG0745	RESPONSE REGULATOR receiver
N015_RS19955	COG0642	Histidine kinase
N015_RS19990	COG0668	transmembrane transport
N015_RS20000	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N015_RS20020	COG3039	Transposase
N015_RS20045	COG1204	response to ionizing radiation
N015_RS20075	COG0477	Major facilitator Superfamily
N015_RS20090	COG1309	transcriptional regulator
N015_RS20120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N015_RS20135	COG2267	carboxylic ester hydrolase activity
N015_RS20145	COG1132	(ABC) transporter
N015_RS20160	COG1643	Atp-dependent helicase
N015_RS20165	COG0318	PFAM AMP-dependent synthetase and ligase
N015_RS20170	COG0318	PFAM AMP-dependent synthetase and ligase
N015_RS20180	COG2030	dehydratase
N015_RS20185	COG3866	Pectate lyase
N015_RS20200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N015_RS20205	COG2271	Major facilitator Superfamily
N015_RS20260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N015_RS20265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N015_RS20275	COG0259	pyridoxamine-phosphate oxidase activity
N015_RS20280	COG2885	chlorophyll binding
N015_RS20290	COG1199	ATP-dependent helicase activity
N015_RS20300	COG3248	Nucleoside-binding outer membrane protein
N015_RS20325	COG3012	SEC-C Motif Domain Protein
N015_RS20360	COG0653	protein targeting
N015_RS20365	COG0625	glutathione transferase activity
N015_RS20370	COG2366	antibiotic biosynthetic process
N015_RS20375	COG1793	dna ligase
N015_RS20375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N015_RS20380	COG1793	dna ligase
N015_RS20390	COG4215	(ABC) transporter
N015_RS20395	COG4160	amino acid transport
N015_RS20410	COG1201	RNA secondary structure unwinding
N015_RS20425	COG0717	Belongs to the dCTP deaminase family
N015_RS20430	COG1278	Cold shock
N015_RS20435	COG0489	protein tyrosine kinase activity
N015_RS20440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N015_RS20440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N015_RS20445	COG2878	Part of a membrane complex involved in electron transport
N015_RS20450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N015_RS20460	COG2197	response regulator
N015_RS20480	COG0137	argininosuccinate synthase activity
N015_RS20490	COG0418	dihydroorotase activity
N015_RS20495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N015_RS20500	COG2906	2 iron, 2 sulfur cluster binding
N015_RS20510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N015_RS20515	COG0243	molybdopterin cofactor binding
N015_RS20530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N015_RS20535	COG3842	ATPase activity
N015_RS20540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N015_RS20550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N015_RS20570	COG0765	amino acid transport
N015_RS20575	COG0765	amino acid transport
N015_RS20580	COG1126	abc transporter atp-binding protein
N015_RS20605	COG0596	Alpha beta hydrolase
N015_RS20610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N015_RS20615	COG0583	DNA-binding transcription factor activity
N015_RS20625	COG1181	Belongs to the D-alanine--D-alanine ligase family
N015_RS20630	COG0254	rRNA binding
N015_RS20640	COG0069	glutamate synthase activity
N015_RS20675	COG1695	Transcriptional regulator
N015_RS20680	COG2375	cellular response to nickel ion
N015_RS20690	COG4628	conserved protein (DUF2132)
N015_RS20710	COG0523	cobalamin synthesis protein
N015_RS20720	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS20745	COG2188	Transcriptional regulator
N015_RS20770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N015_RS20780	COG2226	methyltransferase
N015_RS20785	COG0500	methyltransferase
N015_RS20790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N015_RS20795	COG1381	Involved in DNA repair and RecF pathway recombination
N015_RS20800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N015_RS20805	COG0571	ribonuclease III activity
N015_RS20815	COG0681	Belongs to the peptidase S26 family
N015_RS20820	COG0481	GTPase activity
N015_RS20825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N015_RS20855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N015_RS20870	COG0642	Histidine kinase
N015_RS20900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N015_RS20905	COG1024	Enoyl-CoA hydratase
N015_RS20905	COG1250	3-hydroxyacyl-CoA dehydrogenase
N015_RS20925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N015_RS20925	COG1116	anion transmembrane transporter activity
N015_RS20935	COG3665	Urea carboxylase-associated protein
N015_RS20940	COG0439	Biotin carboxylase
N015_RS20965	COG2267	carboxylic ester hydrolase activity
N015_RS21010	COG1902	pentaerythritol trinitrate reductase activity
N015_RS21015	COG0640	Transcriptional regulator
N015_RS21045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N015_RS21050	COG1349	DNA-binding transcription factor activity
N015_RS21055	COG0154	amidase activity
N015_RS21060	COG0659	secondary active sulfate transmembrane transporter activity
N015_RS21095	COG0697	spore germination
N015_RS21120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
N015_RS21130	COG4191	Histidine kinase
N015_RS21140	COG0784	Response regulator, receiver
N015_RS21140	COG4191	Histidine kinase
N015_RS21150	COG0477	Major facilitator Superfamily
N015_RS21185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS21195	COG1538	Outer membrane efflux protein
N015_RS21200	COG0477	Major facilitator Superfamily
N015_RS21205	COG0183	Belongs to the thiolase family
N015_RS21210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N015_RS21215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N015_RS21220	COG1414	Transcriptional regulator
N015_RS21230	COG0306	phosphate transporter
N015_RS21235	COG0433	COG0433 Predicted ATPase
N015_RS21245	COG0788	formyltetrahydrofolate deformylase activity
N015_RS21255	COG2925	Exonuclease
N015_RS21295	COG0494	nUDIX hydrolase
N015_RS21300	COG0714	Associated with various cellular activities
N015_RS21320	COG0469	pyruvate kinase activity
N015_RS21325	COG0633	Ferredoxin
N015_RS21335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N015_RS21355	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N015_RS21355	COG3264	Mechanosensitive ion channel
N015_RS21370	COG0402	S-adenosylhomocysteine deaminase activity
N015_RS21380	COG2807	transmembrane transport
N015_RS21385	COG2207	Transcriptional regulator
N015_RS21395	COG3121	Chaperone
N015_RS21420	COG2197	response regulator
N015_RS21435	COG0784	Response regulator, receiver
N015_RS21435	COG2205	protein histidine kinase activity
N015_RS21450	COG2249	NAD(P)H dehydrogenase (quinone) activity
N015_RS21475	COG1309	transcriptional regulator
N015_RS21505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N015_RS21545	COG2814	Major facilitator Superfamily
N015_RS21550	COG1902	pentaerythritol trinitrate reductase activity
N015_RS21565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N015_RS21570	COG0583	DNA-binding transcription factor activity
N015_RS21580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N015_RS21650	COG3642	lipopolysaccharide core region biosynthetic process
N015_RS21660	COG0642	Histidine kinase
N015_RS21675	COG0459	protein refolding
N015_RS21680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N015_RS21685	COG3030	protein affecting phage T7 exclusion by the F plasmid
N015_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS21705	COG3695	enzyme binding
N015_RS21725	COG0668	transmembrane transport
N015_RS21730	COG1666	GTP binding
N015_RS21740	COG4191	Histidine kinase
N015_RS21740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N015_RS21745	COG2096	Adenosyltransferase
N015_RS21750	COG0494	nUDIX hydrolase
N015_RS21760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N015_RS21765	COG0653	protein targeting
N015_RS21775	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N015_RS21780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N015_RS21795	COG1181	Belongs to the D-alanine--D-alanine ligase family
N015_RS21800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N015_RS21805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N015_RS21810	COG0772	Belongs to the SEDS family
N015_RS21815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N015_RS21820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N015_RS21825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N015_RS21830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N015_RS21845	COG0275	rRNA processing
N015_RS21850	COG2001	Belongs to the MraZ family
N015_RS21865	COG3107	peptidoglycan biosynthetic process
N015_RS21870	COG0792	nuclease activity
N015_RS21875	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N015_RS21880	COG2823	Periplasmic or secreted lipoprotein
N015_RS21885	COG2969	positive regulation of protein catabolic process
N015_RS21890	COG0625	glutathione transferase activity
N015_RS21895	COG2857	Cytochrome c1
N015_RS21900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N015_RS21905	COG0723	plastoquinol--plastocyanin reductase activity
N015_RS21910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N015_RS21915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N015_RS21925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N015_RS21930	COG0180	Tryptophanyl-tRNA synthetase
N015_RS21950	COG0175	sulfate reduction
N015_RS21960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N015_RS21965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N015_RS21970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N015_RS21975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N015_RS21980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N015_RS22000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N015_RS22005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N015_RS22010	COG1127	ABC transporter
N015_RS22020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N015_RS22030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N015_RS22035	COG1137	ATPase activity
N015_RS22040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N015_RS22045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N015_RS22055	COG1660	Displays ATPase and GTPase activities
N015_RS22085	COG0312	modulator of DNA gyrase
N015_RS22090	COG3028	Belongs to the UPF0307 family
N015_RS22095	COG0312	modulator of DNA gyrase
N015_RS22100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N015_RS22110	COG1530	ribonuclease E activity
N015_RS22115	COG0424	maF-like protein
N015_RS22125	COG1792	Involved in formation and maintenance of cell shape
N015_RS22130	COG1077	Cell shape determining protein MreB Mrl
N015_RS22135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N015_RS22140	COG0154	amidase activity
N015_RS22145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N015_RS22150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N015_RS22155	COG0530	calcium, potassium:sodium antiporter activity
N015_RS22160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N015_RS22175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N015_RS22175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N015_RS22175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N015_RS22180	COG1105	Belongs to the carbohydrate kinase PfkB family
N015_RS22190	COG1609	Transcriptional regulator
N015_RS22195	COG0084	hydrolase, TatD family'
N015_RS22205	COG3023	N-Acetylmuramoyl-L-alanine amidase
N015_RS22225	COG2304	oxidoreductase activity
N015_RS22260	COG0560	Phosphoserine phosphatase
N015_RS22270	COG1358	cellular component organization or biogenesis
N015_RS22305	COG4969	Belongs to the N-Me-Phe pilin family
N015_RS22325	COG0237	dephospho-CoA kinase activity
N015_RS22330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N015_RS22355	COG1252	NADH dehydrogenase
N015_RS22360	COG2205	protein histidine kinase activity
N015_RS22360	COG5002	protein histidine kinase activity
N015_RS22360	COG0784	Response regulator, receiver
N015_RS22365	COG0745	RESPONSE REGULATOR receiver
N015_RS22365	COG3706	GGDEF domain
N015_RS22390	COG0542	response to heat
N015_RS22440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS22480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N015_RS22485	COG1047	Peptidyl-prolyl cis-trans
N015_RS22490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N015_RS22495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N015_RS22500	COG0196	riboflavin kinase activity
N015_RS22505	COG0728	peptidoglycan biosynthetic process
N015_RS22510	COG0268	Binds directly to 16S ribosomal RNA
N015_RS22515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N015_RS22520	COG3045	CreA protein
N015_RS22525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N015_RS22530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N015_RS22535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N015_RS22540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N015_RS22545	COG0142	geranyltranstransferase activity
N015_RS22550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N015_RS22555	COG0545	Peptidyl-prolyl cis-trans isomerase
N015_RS22565	COG2862	Uncharacterized protein family, UPF0114
N015_RS22575	COG1067	ATP-dependent peptidase activity
N015_RS22595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N015_RS22600	COG0488	(ABC) transporter
N015_RS22610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N015_RS22615	COG0523	cobalamin synthesis protein
N015_RS22620	COG2879	small protein
N015_RS22625	COG1966	Carbon starvation protein
N015_RS22640	COG1970	mechanosensitive ion channel activity
N015_RS22650	COG2197	response regulator
N015_RS22655	COG2813	Specifically methylates the guanine in position
N015_RS22665	COG1294	oxidase, subunit
N015_RS22670	COG1271	oxidase subunit
N015_RS22675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N015_RS22680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N015_RS22685	COG2080	2 iron, 2 sulfur cluster binding
N015_RS22690	COG2252	PERMEase
N015_RS22695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N015_RS22705	COG2321	neutral zinc metallopeptidase
N015_RS22715	COG0546	phosphoglycolate phosphatase activity
N015_RS22720	COG1946	Acyl-CoA thioesterase
N015_RS22730	COG0123	including yeast histone deacetylase and acetoin utilization protein
N015_RS22740	COG0513	Belongs to the DEAD box helicase family
N015_RS22745	COG0697	spore germination
N015_RS22750	COG1522	sequence-specific DNA binding
N015_RS22755	COG1199	ATP-dependent helicase activity
N015_RS22755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N015_RS22765	COG3416	Protein conserved in bacteria
N015_RS22800	COG3237	CsbD-like
N015_RS22890	COG1122	ATPase activity
N015_RS23000	COG1643	Atp-dependent helicase
N015_RS23025	COG1522	sequence-specific DNA binding
N015_RS23035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N015_RS23040	COG1960	acyl-CoA dehydrogenase activity
N015_RS23045	COG2205	protein histidine kinase activity
N015_RS23045	COG0784	Response regulator, receiver
N015_RS23045	COG5002	protein histidine kinase activity
N015_RS23050	COG0351	phosphomethylpyrimidine kinase
N015_RS23055	COG0352	thiamine-phosphate diphosphorylase activity
N015_RS23070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N015_RS23085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N015_RS23090	COG1702	phosphate starvation-inducible protein PhoH
N015_RS23095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N015_RS23100	COG4535	Mg2 and Co2 transporter CorC
N015_RS23105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N015_RS23110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N015_RS23120	COG0495	leucyl-tRNA aminoacylation
N015_RS23145	COG2951	lytic endotransglycosylase activity
N015_RS23150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N015_RS23155	COG0321	lipoyl(octanoyl) transferase activity
N015_RS23160	COG2921	Belongs to the UPF0250 family
N015_RS23165	COG1686	Belongs to the peptidase S11 family
N015_RS23175	COG2951	lytic endotransglycosylase activity
N015_RS23180	COG0772	Belongs to the SEDS family
N015_RS23185	COG0768	penicillin binding
N015_RS23190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N015_RS23200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N015_RS23205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N015_RS23210	COG2094	Belongs to the DNA glycosylase MPG family
N015_RS23215	COG0586	Pfam SNARE associated Golgi protein
N015_RS23225	COG1346	cytolysis
N015_RS23245	COG0702	epimerase
N015_RS23260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N015_RS23265	COG1012	belongs to the aldehyde dehydrogenase family
N015_RS23270	COG4303	Ethanolamine ammonia lyase large subunit
N015_RS23275	COG4302	ethanolamine ammonia-lyase activity
N015_RS23280	COG0456	acetyltransferase
N015_RS23285	COG0586	Pfam SNARE associated Golgi protein
N015_RS23295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N015_RS23310	COG0625	glutathione transferase activity
N015_RS23320	COG4944	Protein of unknown function (DUF1109)
N015_RS23325	COG1595	DNA-templated transcription, initiation
N015_RS23335	COG3220	belongs to the UPF0276 family
N015_RS23350	COG1722	exodeoxyribonuclease VII activity
N015_RS23355	COG0142	geranyltranstransferase activity
N015_RS23360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N015_RS23370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N015_RS23375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N015_RS23380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N015_RS23385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N015_RS23400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N015_RS23400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N015_RS23405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N015_RS23415	COG2264	protein methyltransferase activity
N015_RS23420	COG3118	belongs to the thioredoxin family
N015_RS23455	COG3047	cAMP biosynthetic process
N015_RS23475	COG0668	transmembrane transport
N015_RS23490	COG1902	pentaerythritol trinitrate reductase activity
N015_RS23495	COG0629	single-stranded DNA binding
N015_RS23500	COG2814	Major facilitator Superfamily
N015_RS23505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N015_RS23510	COG2193	ferroxidase activity
N015_RS23520	COG0203	ribosomal protein L17
N015_RS23525	COG0202	RNA polymerase activity
N015_RS23530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N015_RS23535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N015_RS23540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N015_RS23545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N015_RS23555	COG0200	Binds to the 23S rRNA
N015_RS23560	COG1841	ribosomal large subunit assembly
N015_RS23565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N015_RS23570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N015_RS23575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N015_RS23580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N015_RS23585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N015_RS23590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N015_RS23595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N015_RS23600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N015_RS23605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N015_RS23610	COG0255	Belongs to the universal ribosomal protein uL29 family
N015_RS23615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N015_RS23620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N015_RS23625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N015_RS23630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N015_RS23635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N015_RS23640	COG0089	rRNA binding
N015_RS23645	COG0088	Forms part of the polypeptide exit tunnel
N015_RS23650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N015_RS23655	COG0051	transcription antitermination factor activity, RNA binding
N015_RS23660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N015_RS23665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N015_RS23670	COG0049	tRNA binding
N015_RS23675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N015_RS23680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N015_RS23685	COG0085	RNA polymerase activity
N015_RS23690	COG0222	ribosome binding
N015_RS23695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N015_RS23700	COG0081	regulation of translation
N015_RS23705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N015_RS23745	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N015_RS23785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N015_RS23795	COG0739	heme binding
N015_RS23800	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N015_RS23805	COG0316	Belongs to the HesB IscA family
N015_RS23810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N015_RS23830	COG0537	adenosine 5'-monophosphoramidase activity
N015_RS23835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
N015_RS23840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N015_RS23845	COG1765	OsmC-like protein
N015_RS23855	COG0095	Lipoate-protein ligase
N015_RS23860	COG0134	indole-3-glycerol-phosphate synthase activity
N015_RS23865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N015_RS23870	COG0512	Glutamine amidotransferase of anthranilate synthase
N015_RS23885	COG0546	phosphoglycolate phosphatase activity
N015_RS23890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N015_RS23900	COG1176	ABC-type spermidine putrescine transport system, permease component I
N015_RS23910	COG3842	ATPase activity
N015_RS23915	COG2197	response regulator
N015_RS23920	COG4585	Histidine kinase
N015_RS23930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N015_RS23935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N015_RS23940	COG3178	'Phosphotransferase
N015_RS23945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N015_RS23950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N015_RS23955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N015_RS23960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N015_RS23965	COG2967	ApaG domain
N015_RS23970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N015_RS23975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N015_RS23980	COG2766	serine protein kinase
N015_RS23985	COG2718	Belongs to the UPF0229 family
N015_RS23990	COG2719	SpoVR family
N015_RS23995	COG0617	tRNA 3'-terminal CCA addition
N015_RS24005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N015_RS24010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N015_RS24015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N015_RS24020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N015_RS24025	COG0358	DNA primase activity
N015_RS24030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N015_RS24045	COG1942	4-Oxalocrotonate Tautomerase
N015_RS24060	COG3550	peptidyl-serine autophosphorylation
N015_RS24070	COG1335	isochorismatase
N015_RS24095	COG0745	RESPONSE REGULATOR receiver
N015_RS24105	COG2198	Histidine kinase
N015_RS24105	COG0643	Histidine kinase
N015_RS24110	COG0840	transmembrane signaling receptor activity
N015_RS24115	COG0835	chemotaxis
N015_RS24125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N015_RS24130	COG2201	protein-glutamate methylesterase activity
N015_RS24135	COG1349	DNA-binding transcription factor activity
N015_RS24145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N015_RS24150	COG0463	Glycosyl transferase, family 2
N015_RS24155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N015_RS24155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N015_RS24160	COG0726	polysaccharide deacetylase
N015_RS24165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N015_RS24170	COG2076	Multidrug Resistance protein
N015_RS24175	COG2076	Multidrug Resistance protein
N015_RS24215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N015_RS24220	COG1025	Belongs to the peptidase M16 family
N015_RS24230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N015_RS24235	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
N015_RS24245	COG0535	radical SAM domain protein
N015_RS24260	COG1960	acyl-CoA dehydrogenase activity
N015_RS24265	COG3706	GGDEF domain
N015_RS24270	COG1960	acyl-CoA dehydrogenase activity
N015_RS24290	COG2226	methyltransferase
N015_RS24290	COG1073	alpha beta
N015_RS24295	COG0156	8-amino-7-oxononanoate synthase activity
N015_RS24300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N015_RS24305	COG1040	competence protein
N015_RS24310	COG3585	molybdate ion transport
N015_RS24310	COG2005	Transcriptional regulator
N015_RS24320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N015_RS24325	COG3842	ATPase activity
N015_RS24330	COG1177	transmembrane transport
N015_RS24335	COG1175	transmembrane transport
N015_RS24345	COG1609	Transcriptional regulator
N015_RS24350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N015_RS24365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N015_RS24380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N015_RS24385	COG1595	DNA-templated transcription, initiation
N015_RS24390	COG3712	iron ion homeostasis
N015_RS24405	COG0625	glutathione transferase activity
N015_RS24410	COG4452	Inner membrane protein CreD
N015_RS24415	COG2205	protein histidine kinase activity
N015_RS24420	COG0745	RESPONSE REGULATOR receiver
N015_RS24430	COG0204	Acyl-transferase
N015_RS24470	COG1063	alcohol dehydrogenase
N015_RS24500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N015_RS24510	COG0436	Aminotransferase
N015_RS24525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N015_RS24525	COG1017	nitric oxide dioxygenase activity
N015_RS24530	COG4638	Rieske (2fe-2S)
N015_RS24535	COG3469	chitinase activity
N015_RS24545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N015_RS24550	COG0247	lactate metabolic process
N015_RS24550	COG2181	nitrate reductase activity
N015_RS24555	COG0446	pyridine nucleotide-disulphide oxidoreductase
N015_RS24555	COG1902	pentaerythritol trinitrate reductase activity
N015_RS24600	COG0126	phosphoglycerate kinase activity
N015_RS24610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N015_RS24615	COG4106	trans-aconitate 2-methyltransferase activity
N015_RS24620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N015_RS24625	COG2337	Toxic component of a toxin-antitoxin (TA) module
N015_RS24630	COG2336	PFAM SpoVT AbrB
N015_RS24635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N015_RS24640	COG1422	Protein of unknown function (DUF1090)
N015_RS24650	COG0642	Histidine kinase
N015_RS24695	COG1349	DNA-binding transcription factor activity
N015_RS24700	COG2084	Dehydrogenase
N015_RS24705	COG3395	kinase activity
N015_RS24710	COG0235	Class ii aldolase
N015_RS24715	COG2610	gluconate transmembrane transporter activity
N015_RS24720	COG3622	Belongs to the hyi family
N015_RS24730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N015_RS24735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N015_RS24740	COG0513	Belongs to the DEAD box helicase family
N015_RS24745	COG2353	YceI-like domain
N015_RS24750	COG3038	cytochrome b561
N015_RS24765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N015_RS24770	COG1272	protein, Hemolysin III
N015_RS24790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N015_RS24810	COG3052	prosthetic group binding
N015_RS24815	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N015_RS24830	COG1192	Involved in chromosome partitioning
N015_RS24850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N015_RS24875	COG2986	histidine ammonia-lyase
N015_RS24905	COG2226	methyltransferase
N015_RS24915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N015_RS24925	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS24930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N015_RS24935	COG0583	DNA-binding transcription factor activity
N015_RS24940	COG2814	Major facilitator Superfamily
N015_RS24945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N015_RS24955	COG0493	'glutamate synthase
N015_RS24960	COG0070	glutamate synthase
N015_RS24960	COG0067	glutamate synthase
N015_RS24960	COG0069	glutamate synthase activity
N015_RS24970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N015_RS24975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N015_RS25020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N015_RS25020	COG0301	tRNA thio-modification
N015_RS25050	COG3852	Histidine kinase
N015_RS25060	COG0667	Aldo Keto reductase
N015_RS25065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N015_RS25075	COG4771	TonB-dependent receptor
N015_RS25080	COG1609	Transcriptional regulator
N015_RS25085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N015_RS25090	COG1045	serine acetyltransferase
N015_RS25095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N015_RS25140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N015_RS25145	COG2011	ABC-type metal ion transport system permease component
N015_RS25155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N015_RS25160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS25165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N015_RS25190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N015_RS25200	COG2175	clavaminate synthase activity
N015_RS25210	COG2369	cell adhesion
N015_RS25225	COG3829	transcription factor binding
N015_RS25235	COG2271	Major facilitator Superfamily
N015_RS25260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N015_RS25265	COG4208	sulfate ABC transporter
N015_RS25275	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N015_RS25295	COG0745	RESPONSE REGULATOR receiver
N015_RS25295	COG3706	GGDEF domain
N015_RS25300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N015_RS25305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N015_RS25315	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
N015_RS25320	COG0494	nUDIX hydrolase
N015_RS25335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N015_RS25340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N015_RS25355	COG0179	Fumarylacetoacetate (FAA) hydrolase
N015_RS25360	COG0277	FAD linked oxidase domain protein
N015_RS25365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N015_RS25400	COG1177	transmembrane transport
N015_RS25405	COG1176	ABC-type spermidine putrescine transport system, permease component I
N015_RS25410	COG3842	ATPase activity
N015_RS25430	COG0174	glutamine synthetase
N015_RS25435	COG0174	glutamine synthetase
N015_RS25470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N015_RS25475	COG0601	transmembrane transport
N015_RS25480	COG0747	negative chemotaxis
N015_RS25485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N015_RS25525	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N015_RS25530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N015_RS25535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N015_RS25540	COG3287	FIST C domain
N015_RS25540	COG2200	EAL domain
N015_RS25540	COG2199	diguanylate cyclase activity
N015_RS25545	COG0189	ligase activity
N015_RS25545	COG4067	protein conserved in archaea
N015_RS25550	COG0189	ligase activity
N015_RS25555	COG2205	protein histidine kinase activity
N015_RS25560	COG0745	RESPONSE REGULATOR receiver
N015_RS25565	COG2183	response to ionizing radiation
N015_RS25575	COG2918	glutathione biosynthetic process
N015_RS25580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N015_RS25580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N015_RS25595	COG1522	sequence-specific DNA binding
N015_RS25615	COG0509	glycine decarboxylation via glycine cleavage system
N015_RS25620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N015_RS25625	COG1178	ABC-type Fe3 transport system permease component
N015_RS25635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N015_RS25640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N015_RS25645	COG0006	proline dipeptidase activity
N015_RS25650	COG3079	Belongs to the UPF0149 family
N015_RS25670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N015_RS25700	COG2271	Major facilitator Superfamily
N015_RS25715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N015_RS25730	COG2186	Transcriptional regulator
N015_RS25735	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N015_RS25740	COG0765	amino acid transport
N015_RS25750	COG1126	abc transporter atp-binding protein
N015_RS25760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N015_RS25770	COG0586	Pfam SNARE associated Golgi protein
N015_RS25775	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
N015_RS25780	COG0672	)-iron permease
N015_RS25805	COG1280	lysine exporter protein (LysE YggA)
N015_RS25815	COG0488	(ABC) transporter
N015_RS25840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N015_RS25860	COG0181	hydroxymethylbilane synthase activity
N015_RS25870	COG0745	RESPONSE REGULATOR receiver
N015_RS25870	COG2972	Histidine kinase
N015_RS25875	COG0165	Argininosuccinate lyase
N015_RS25880	COG0625	glutathione transferase activity
N015_RS25900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N015_RS25910	COG1965	Belongs to the frataxin family
N015_RS25920	COG0019	diaminopimelate decarboxylase activity
N015_RS25925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N015_RS25935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N015_RS25940	COG0546	phosphoglycolate phosphatase activity
N015_RS25950	COG0432	Pfam Uncharacterised protein family UPF0047
N015_RS25955	COG0004	ammonium transporteR
N015_RS25960	COG0347	Belongs to the P(II) protein family
N015_RS25975	COG3549	Plasmid maintenance system killer
N015_RS25995	COG0606	chelatase, subunit chli
N015_RS26005	COG0840	transmembrane signaling receptor activity
N015_RS26010	COG0583	DNA-binding transcription factor activity
N015_RS26015	COG0534	Mate efflux family protein
N015_RS26055	COG2226	methyltransferase
N015_RS26070	COG0438	transferase activity, transferring glycosyl groups
N015_RS26080	COG1696	Membrane protein involved in D-alanine export
N015_RS26100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
N015_RS26130	COG1216	Glycosyl transferase, family 2
N015_RS26170	COG0582	viral genome integration into host DNA
N015_RS26180	COG0840	transmembrane signaling receptor activity
N015_RS26185	COG0840	transmembrane signaling receptor activity
N015_RS26260	COG1216	Glycosyl transferase, family 2
N015_RS26260	COG0438	transferase activity, transferring glycosyl groups
N015_RS26275	COG1028	Short-chain dehydrogenase reductase Sdr
N015_RS26285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N015_RS26295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N015_RS26335	COG1595	DNA-templated transcription, initiation
N015_RS26340	COG3806	Anti-sigma factor
N015_RS26345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N015_RS26355	COG2204	response regulator
N015_RS26375	COG0783	Belongs to the Dps family
N015_RS26390	COG0662	Cupin 2, conserved barrel domain protein
N015_RS26390	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family