locus-tag	class	description
I6H70_RS00015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H70_RS00020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H70_RS00040	COG0826	peptidase U32
I6H70_RS00065	COG4771	TonB-dependent receptor
I6H70_RS00085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H70_RS00135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H70_RS00145	COG3300	MHYT domain
I6H70_RS00145	COG5001	Diguanylate cyclase
I6H70_RS00160	COG2130	NADP-dependent
I6H70_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS00170	COG3135	benzoate transporter
I6H70_RS00175	COG1677	Flagellar hook-basal body complex protein FliE
I6H70_RS00210	COG0745	RESPONSE REGULATOR receiver
I6H70_RS00250	COG1987	bacterial-type flagellum assembly
I6H70_RS00265	COG2032	superoxide dismutase activity
I6H70_RS00295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6H70_RS00300	COG0643	Histidine kinase
I6H70_RS00300	COG0784	Response regulator, receiver
I6H70_RS00300	COG2198	Histidine kinase
I6H70_RS00305	COG2201	protein-glutamate methylesterase activity
I6H70_RS00310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6H70_RS00315	COG1360	Flagellar Motor Protein
I6H70_RS00320	COG1192	Involved in chromosome partitioning
I6H70_RS00330	COG0835	chemotaxis
I6H70_RS00345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6H70_RS00355	COG4133	protoheme IX ABC transporter activity
I6H70_RS00375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6H70_RS00420	COG0500	methyltransferase
I6H70_RS00430	COG0501	Belongs to the peptidase M48B family
I6H70_RS00440	COG0436	Aminotransferase
I6H70_RS00445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H70_RS00450	COG0386	Belongs to the glutathione peroxidase family
I6H70_RS00460	COG0625	glutathione transferase activity
I6H70_RS00485	COG0640	Transcriptional regulator
I6H70_RS00490	COG2391	methyltransferase activity
I6H70_RS00510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H70_RS00525	COG1136	(ABC) transporter
I6H70_RS00530	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H70_RS00555	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6H70_RS00570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H70_RS00575	COG0471	metal ion transport
I6H70_RS00580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6H70_RS00590	COG0840	transmembrane signaling receptor activity
I6H70_RS00605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H70_RS00610	COG0668	transmembrane transport
I6H70_RS00625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H70_RS00640	COG1346	cytolysis
I6H70_RS00710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H70_RS00725	COG1770	oligopeptidase
I6H70_RS00730	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H70_RS00730	COG1024	Enoyl-CoA hydratase
I6H70_RS00735	COG0183	Belongs to the thiolase family
I6H70_RS00765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H70_RS00775	COG1376	ErfK ybiS ycfS ynhG family protein
I6H70_RS00795	COG0653	protein targeting
I6H70_RS00815	COG0133	tryptophan synthase activity
I6H70_RS00820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H70_RS00825	COG1012	belongs to the aldehyde dehydrogenase family
I6H70_RS00830	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6H70_RS00835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H70_RS00845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6H70_RS00880	COG4964	Belongs to the GSP D family
I6H70_RS00950	COG0297	glycogen (starch) synthase activity
I6H70_RS00970	COG0438	transferase activity, transferring glycosyl groups
I6H70_RS00975	COG0250	Participates in transcription elongation, termination and antitermination
I6H70_RS00985	COG3206	protein involved in exopolysaccharide biosynthesis
I6H70_RS00985	COG0489	protein tyrosine kinase activity
I6H70_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS01050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H70_RS01055	COG0066	3-isopropylmalate dehydratase activity
I6H70_RS01085	COG0135	phosphoribosylanthranilate isomerase activity
I6H70_RS01090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H70_RS01095	COG0285	dihydrofolate synthase activity
I6H70_RS01100	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H70_RS01105	COG1286	toxin biosynthetic process
I6H70_RS01140	COG0789	Transcriptional regulator
I6H70_RS01155	COG4772	TonB-dependent receptor
I6H70_RS01160	COG1660	Displays ATPase and GTPase activities
I6H70_RS01165	COG0252	asparaginase activity
I6H70_RS01170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6H70_RS01205	COG1271	oxidase subunit
I6H70_RS01210	COG1294	oxidase, subunit
I6H70_RS01230	COG1902	pentaerythritol trinitrate reductase activity
I6H70_RS01230	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H70_RS01255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H70_RS01260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H70_RS01265	COG0705	Rhomboid family
I6H70_RS01280	COG0308	aminopeptidase N
I6H70_RS01285	COG4447	cellulose binding
I6H70_RS01295	COG1007	ATP synthesis coupled electron transport
I6H70_RS01310	COG0713	ATP synthesis coupled electron transport
I6H70_RS01320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H70_RS01325	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6H70_RS01350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H70_RS01355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H70_RS01375	COG0243	molybdopterin cofactor binding
I6H70_RS01380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H70_RS01385	COG0515	serine threonine protein kinase
I6H70_RS01385	COG2815	serine threonine protein kinase
I6H70_RS01390	COG2223	nitrite transmembrane transporter activity
I6H70_RS01395	COG3707	response regulator
I6H70_RS01400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H70_RS01430	COG0714	Associated with various cellular activities
I6H70_RS01450	COG0167	dihydroorotate dehydrogenase activity
I6H70_RS01455	COG3130	regulation of translation
I6H70_RS01460	COG0116	Belongs to the methyltransferase superfamily
I6H70_RS01460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H70_RS01470	COG3171	Protein conserved in bacteria
I6H70_RS01545	COG4372	Transposase
I6H70_RS01570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H70_RS01580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H70_RS01590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H70_RS01595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H70_RS01600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H70_RS01605	COG0072	phenylalanine-tRNA ligase activity
I6H70_RS01610	COG0776	regulation of translation
I6H70_RS01630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H70_RS01635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H70_RS01650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6H70_RS01660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H70_RS01665	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6H70_RS01670	COG1683	Conserved Protein
I6H70_RS01695	COG2814	Major facilitator Superfamily
I6H70_RS01700	COG0587	DNA-directed DNA polymerase activity
I6H70_RS01720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H70_RS01745	COG1366	Belongs to the anti-sigma-factor antagonist family
I6H70_RS01750	COG2172	sigma factor antagonist activity
I6H70_RS01760	COG2205	protein histidine kinase activity
I6H70_RS01760	COG0784	Response regulator, receiver
I6H70_RS01765	COG4191	Histidine kinase
I6H70_RS01765	COG0784	Response regulator, receiver
I6H70_RS01770	COG0604	alcohol dehydrogenase
I6H70_RS01775	COG0616	signal peptide processing
I6H70_RS01790	COG2226	methyltransferase
I6H70_RS01805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H70_RS01810	COG0583	DNA-binding transcription factor activity
I6H70_RS01825	COG4372	Transposase
I6H70_RS01835	COG1943	Transposase
I6H70_RS01855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H70_RS01865	COG0745	RESPONSE REGULATOR receiver
I6H70_RS01870	COG2205	protein histidine kinase activity
I6H70_RS01885	COG0183	Belongs to the thiolase family
I6H70_RS01890	COG0114	fumarate hydratase activity
I6H70_RS01905	COG1054	Belongs to the UPF0176 family
I6H70_RS01915	COG1132	(ABC) transporter
I6H70_RS01920	COG0840	transmembrane signaling receptor activity
I6H70_RS01950	COG0583	DNA-binding transcription factor activity
I6H70_RS01955	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6H70_RS01960	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS01970	COG2079	MmgE PrpD family protein
I6H70_RS01980	COG2301	Belongs to the HpcH HpaI aldolase family
I6H70_RS01995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H70_RS02000	COG0776	regulation of translation
I6H70_RS02010	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS02015	COG1131	(ABC) transporter
I6H70_RS02020	COG0842	Transport permease protein
I6H70_RS02025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H70_RS02025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H70_RS02035	COG2853	Lipoprotein
I6H70_RS02045	COG0745	RESPONSE REGULATOR receiver
I6H70_RS02055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H70_RS02060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H70_RS02125	COG0720	synthase
I6H70_RS02130	COG2056	Na+-H+ antiporter family
I6H70_RS02155	COG2153	protein acetylation
I6H70_RS02160	COG2850	peptidyl-arginine hydroxylation
I6H70_RS02170	COG2915	High frequency lysogenization protein hflD homolog
I6H70_RS02175	COG0482	sulfurtransferase activity
I6H70_RS02195	COG1278	Cold shock
I6H70_RS02200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6H70_RS02205	COG0542	response to heat
I6H70_RS02210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H70_RS02215	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6H70_RS02220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6H70_RS02225	COG0492	ferredoxin-NADP+ reductase activity
I6H70_RS02235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6H70_RS02240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H70_RS02245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H70_RS02250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H70_RS02255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H70_RS02255	COG1648	precorrin-2 dehydrogenase activity
I6H70_RS02290	COG2920	part of a sulfur-relay system
I6H70_RS02295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H70_RS02300	COG0435	Glutathione S-transferase
I6H70_RS02305	COG0745	RESPONSE REGULATOR receiver
I6H70_RS02335	COG0745	RESPONSE REGULATOR receiver
I6H70_RS02350	COG1238	metal cluster binding
I6H70_RS02370	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS02380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H70_RS02385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H70_RS02395	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS02400	COG1024	Enoyl-CoA hydratase
I6H70_RS02410	COG1024	Enoyl-CoA hydratase
I6H70_RS02440	COG1696	Membrane protein involved in D-alanine export
I6H70_RS02450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H70_RS02460	COG0210	DNA helicase
I6H70_RS02480	COG0515	serine threonine protein kinase
I6H70_RS02485	COG2116	formate transmembrane transporter activity
I6H70_RS02495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H70_RS02495	COG2146	nitrite reductase [NAD(P)H] activity
I6H70_RS02505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H70_RS02520	COG4221	oxidoreductase activity
I6H70_RS02535	COG0789	Transcriptional regulator
I6H70_RS02550	COG1090	epimerase
I6H70_RS02555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H70_RS02565	COG1366	Belongs to the anti-sigma-factor antagonist family
I6H70_RS02585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6H70_RS02590	COG0302	gtp cyclohydrolase
I6H70_RS02600	COG0789	Transcriptional regulator
I6H70_RS02605	COG1025	Belongs to the peptidase M16 family
I6H70_RS02620	COG2205	protein histidine kinase activity
I6H70_RS02620	COG0784	Response regulator, receiver
I6H70_RS02640	COG1131	(ABC) transporter
I6H70_RS02670	COG3851	Histidine kinase
I6H70_RS02735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H70_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS02775	COG0604	alcohol dehydrogenase
I6H70_RS02775	COG3321	synthase
I6H70_RS02800	COG0437	4 iron, 4 sulfur cluster binding
I6H70_RS02805	COG2864	formate dehydrogenase
I6H70_RS02810	COG3058	Necessary for formate dehydrogenase activity
I6H70_RS02815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H70_RS02820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H70_RS02825	COG2814	Major facilitator Superfamily
I6H70_RS02830	COG4977	sequence-specific DNA binding
I6H70_RS02880	COG4644	lycopene metabolic process
I6H70_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS02935	COG3685	Protein conserved in bacteria
I6H70_RS02940	COG3264	Mechanosensitive ion channel
I6H70_RS02940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6H70_RS02945	COG1546	Belongs to the CinA family
I6H70_RS02945	COG1058	Belongs to the CinA family
I6H70_RS02950	COG0297	glycogen (starch) synthase activity
I6H70_RS02955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H70_RS02980	COG0739	heme binding
I6H70_RS02985	COG3038	cytochrome b561
I6H70_RS02995	COG3384	dioxygenase
I6H70_RS03000	COG0583	DNA-binding transcription factor activity
I6H70_RS03015	COG3568	Endonuclease Exonuclease Phosphatase
I6H70_RS03020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H70_RS03025	COG0392	lysyltransferase activity
I6H70_RS03050	COG1115	amino acid carrier protein
I6H70_RS03055	COG2911	Protein conserved in bacteria
I6H70_RS03060	COG0729	surface antigen
I6H70_RS03090	COG1609	Transcriptional regulator
I6H70_RS03095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H70_RS03100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H70_RS03110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H70_RS03155	COG0488	(ABC) transporter
I6H70_RS03160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H70_RS03170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H70_RS03175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H70_RS03185	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H70_RS03190	COG1968	undecaprenyl-diphosphatase activity
I6H70_RS03195	COG0840	transmembrane signaling receptor activity
I6H70_RS03210	COG2323	membrane
I6H70_RS03225	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6H70_RS03225	COG0316	Belongs to the HesB IscA family
I6H70_RS03260	COG2223	nitrite transmembrane transporter activity
I6H70_RS03265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H70_RS03280	COG0071	Belongs to the small heat shock protein (HSP20) family
I6H70_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS03320	COG2816	NAD+ diphosphatase activity
I6H70_RS03330	COG1024	Enoyl-CoA hydratase
I6H70_RS03355	COG0535	radical SAM domain protein
I6H70_RS03365	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I6H70_RS03370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H70_RS03410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H70_RS03415	COG0167	dihydroorotate dehydrogenase activity
I6H70_RS03420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H70_RS03425	COG0366	Alpha amylase catalytic
I6H70_RS03460	COG0840	transmembrane signaling receptor activity
I6H70_RS03485	COG5642	Protein of unknown function (DUF2384)
I6H70_RS03540	COG0328	RNA-DNA hybrid ribonuclease activity
I6H70_RS03550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H70_RS03555	COG0741	lytic transglycosylase activity
I6H70_RS03555	COG1388	LysM domain
I6H70_RS03575	COG4174	ABC transporter (Permease)
I6H70_RS03580	COG4239	(ABC) transporter, permease
I6H70_RS03585	COG4172	Belongs to the ABC transporter superfamily
I6H70_RS03600	COG1335	isochorismatase
I6H70_RS03640	COG1733	regulation of RNA biosynthetic process
I6H70_RS03660	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS03665	COG1024	Enoyl-CoA hydratase
I6H70_RS03665	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H70_RS03670	COG0183	Belongs to the thiolase family
I6H70_RS03680	COG4566	intracellular signal transduction
I6H70_RS03685	COG4191	Histidine kinase
I6H70_RS03690	COG0318	PFAM AMP-dependent synthetase and ligase
I6H70_RS03720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H70_RS03725	COG0745	RESPONSE REGULATOR receiver
I6H70_RS03730	COG2801	Transposase and inactivated derivatives
I6H70_RS03755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H70_RS03760	COG0215	cysteine-tRNA ligase activity
I6H70_RS03765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H70_RS03770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H70_RS03805	COG1595	DNA-templated transcription, initiation
I6H70_RS03810	COG0668	transmembrane transport
I6H70_RS03825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H70_RS03835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H70_RS03840	COG2828	Protein conserved in bacteria
I6H70_RS03850	COG0372	Belongs to the citrate synthase family
I6H70_RS03860	COG1802	Transcriptional regulator
I6H70_RS03885	COG0560	Phosphoserine phosphatase
I6H70_RS03900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H70_RS03935	COG4181	ATPase activity
I6H70_RS03940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6H70_RS03960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6H70_RS03990	COG0714	Associated with various cellular activities
I6H70_RS04000	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6H70_RS04005	COG0709	Synthesizes selenophosphate from selenide and ATP
I6H70_RS04015	COG0628	permease
I6H70_RS04050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H70_RS04065	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H70_RS04130	COG0045	succinate-CoA ligase (ADP-forming) activity
I6H70_RS04150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H70_RS04155	COG1053	succinate dehydrogenase
I6H70_RS04160	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6H70_RS04165	COG2009	succinate dehydrogenase
I6H70_RS04185	COG3123	guanosine phosphorylase activity
I6H70_RS04210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6H70_RS04215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H70_RS04220	COG3115	cell septum assembly
I6H70_RS04230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H70_RS04235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H70_RS04250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6H70_RS04250	COG2010	Cytochrome c
I6H70_RS04255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H70_RS04275	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6H70_RS04285	COG0840	transmembrane signaling receptor activity
I6H70_RS04295	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H70_RS04310	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H70_RS04325	COG2010	Cytochrome c
I6H70_RS04330	COG0348	domain, Protein
I6H70_RS04355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H70_RS04365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H70_RS04385	COG0573	inorganic phosphate transmembrane transporter activity
I6H70_RS04400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H70_RS04405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H70_RS04415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H70_RS04440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H70_RS04460	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6H70_RS04465	COG0235	Class ii aldolase
I6H70_RS04475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H70_RS04505	COG2840	Smr protein MutS2
I6H70_RS04510	COG0302	gtp cyclohydrolase
I6H70_RS04515	COG0625	glutathione transferase activity
I6H70_RS04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H70_RS04535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H70_RS04540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H70_RS04550	COG0077	Prephenate dehydratase
I6H70_RS04550	COG1605	Chorismate mutase
I6H70_RS04555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H70_RS04565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6H70_RS04595	COG0402	S-adenosylhomocysteine deaminase activity
I6H70_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS04625	COG0800	Aldolase
I6H70_RS04640	COG4580	involved in the transport of maltose and maltodextrins
I6H70_RS04650	COG0395	ABC-type sugar transport system, permease component
I6H70_RS04655	COG1175	transmembrane transport
I6H70_RS04660	COG1653	transport
I6H70_RS04685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H70_RS04690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H70_RS04695	COG0180	Tryptophanyl-tRNA synthetase
I6H70_RS04700	COG0009	L-threonylcarbamoyladenylate synthase
I6H70_RS04710	COG2350	Protein conserved in bacteria
I6H70_RS04720	COG0745	RESPONSE REGULATOR receiver
I6H70_RS04735	COG0778	Nitroreductase
I6H70_RS04740	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6H70_RS04745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H70_RS04750	COG2354	Protein conserved in bacteria
I6H70_RS04770	COG2207	Transcriptional regulator
I6H70_RS04775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H70_RS04790	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6H70_RS04800	COG0514	ATP-dependent DNA helicase (RecQ)
I6H70_RS04810	COG2832	Protein of unknown function (DUF454)
I6H70_RS04820	COG0625	glutathione transferase activity
I6H70_RS04825	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6H70_RS04830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H70_RS04840	COG0542	response to heat
I6H70_RS04860	COG0121	glutamine amidotransferase
I6H70_RS04870	COG0589	response to stress
I6H70_RS04880	COG0488	(ABC) transporter
I6H70_RS04895	COG3437	response regulator, receiver
I6H70_RS04910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H70_RS04915	COG0489	protein tyrosine kinase activity
I6H70_RS04915	COG3206	protein involved in exopolysaccharide biosynthesis
I6H70_RS04970	COG3135	benzoate transporter
I6H70_RS04975	COG3485	protocatechuate 3,4-dioxygenase
I6H70_RS04980	COG4829	muconolactone delta-isomerase
I6H70_RS04985	COG4948	Mandelate Racemase Muconate Lactonizing
I6H70_RS04990	COG2814	Major facilitator Superfamily
I6H70_RS05020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H70_RS05030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H70_RS05035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H70_RS05040	COG1414	Transcriptional regulator
I6H70_RS05045	COG0789	Transcriptional regulator
I6H70_RS05070	COG1113	amino acid transport
I6H70_RS05075	COG0084	hydrolase, TatD family'
I6H70_RS05090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H70_RS05095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H70_RS05105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H70_RS05110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H70_RS05125	COG0416	fatty acid biosynthetic process
I6H70_RS05130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H70_RS05140	COG0424	maF-like protein
I6H70_RS05145	COG0616	signal peptide processing
I6H70_RS05145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H70_RS05150	COG0546	phosphoglycolate phosphatase activity
I6H70_RS05160	COG1530	ribonuclease E activity
I6H70_RS05165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H70_RS05170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H70_RS05175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6H70_RS05180	COG2835	tetraacyldisaccharide 4'-kinase activity
I6H70_RS05185	COG1663	tetraacyldisaccharide 4'-kinase activity
I6H70_RS05195	COG0811	peptide transport
I6H70_RS05215	COG1136	(ABC) transporter
I6H70_RS05220	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H70_RS05235	COG0584	glycerophosphoryl diester phosphodiesterase
I6H70_RS05240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H70_RS05250	COG1477	protein flavinylation
I6H70_RS05260	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H70_RS05275	COG1805	sodium ion transport
I6H70_RS05290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H70_RS05300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H70_RS05315	COG1793	dna ligase
I6H70_RS05320	COG1201	RNA secondary structure unwinding
I6H70_RS05350	COG3956	TIGRFAM MazG family protein
I6H70_RS05355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H70_RS05360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H70_RS05375	COG2860	membrane
I6H70_RS05380	COG5002	protein histidine kinase activity
I6H70_RS05380	COG2205	protein histidine kinase activity
I6H70_RS05380	COG0784	Response regulator, receiver
I6H70_RS05385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H70_RS05385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6H70_RS05405	COG0583	DNA-binding transcription factor activity
I6H70_RS05410	COG1846	Transcriptional regulator
I6H70_RS05415	COG0367	asparagine synthase
I6H70_RS05420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H70_RS05420	COG0189	ligase activity
I6H70_RS05425	COG1363	Peptidase, m42
I6H70_RS05435	COG3089	Belongs to the UPF0270 family
I6H70_RS05455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H70_RS05460	COG3162	membrane
I6H70_RS05480	COG2853	Lipoprotein
I6H70_RS05485	COG1560	Kdo2-lipid A biosynthetic process
I6H70_RS05490	COG0850	regulation of cytokinetic process
I6H70_RS05495	COG2894	cell division
I6H70_RS05500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6H70_RS05505	COG0564	pseudouridine synthase activity
I6H70_RS05510	COG1362	aminopeptidase activity
I6H70_RS05525	COG2200	EAL domain
I6H70_RS05525	COG2199	diguanylate cyclase activity
I6H70_RS05550	COG1555	photosystem II stabilization
I6H70_RS05560	COG1256	bacterial-type flagellum assembly
I6H70_RS05575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6H70_RS05580	COG4786	Flagellar basal body rod
I6H70_RS05585	COG4787	bacterial-type flagellum-dependent cell motility
I6H70_RS05600	COG1558	bacterial-type flagellum-dependent cell motility
I6H70_RS05610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6H70_RS05615	COG0784	Response regulator, receiver
I6H70_RS05615	COG0835	chemotaxis
I6H70_RS05620	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS05645	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6H70_RS05675	COG2239	Acts as a magnesium transporter
I6H70_RS05700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6H70_RS05705	COG0527	aspartate kinase activity
I6H70_RS05710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H70_RS05720	COG2983	Belongs to the UPF0260 family
I6H70_RS05730	COG3100	YcgL domain-containing protein
I6H70_RS05780	COG0791	NLP P60 protein
I6H70_RS05785	COG0791	NLP P60 protein
I6H70_RS05795	COG4890	Cyd operon protein YbgT
I6H70_RS05800	COG1294	oxidase, subunit
I6H70_RS05825	COG2818	Glycosylase
I6H70_RS05830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H70_RS05835	COG0037	tRNA processing
I6H70_RS05855	COG3091	SprT-like family
I6H70_RS05865	COG2814	Major facilitator Superfamily
I6H70_RS05870	COG4459	periplasmic nitrate reductase
I6H70_RS05880	COG0243	molybdopterin cofactor binding
I6H70_RS05885	COG3043	anaerobic respiration
I6H70_RS05890	COG3005	denitrification pathway
I6H70_RS05910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H70_RS05920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H70_RS05925	COG2226	methyltransferase
I6H70_RS05950	COG1131	(ABC) transporter
I6H70_RS05980	COG2937	Belongs to the GPAT DAPAT family
I6H70_RS05995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H70_RS06010	COG0642	Histidine kinase
I6H70_RS06050	COG2132	Multicopper oxidase
I6H70_RS06070	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6H70_RS06095	COG1309	transcriptional regulator
I6H70_RS06115	COG0742	ribosomal rna small subunit methyltransferase
I6H70_RS06125	COG1801	Protein of unknown function DUF72
I6H70_RS06135	COG1214	PFAM Peptidase M22, glycoprotease
I6H70_RS06145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6H70_RS06205	COG1902	pentaerythritol trinitrate reductase activity
I6H70_RS06210	COG3383	formate dehydrogenase (NAD+) activity
I6H70_RS06240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6H70_RS06250	COG3842	ATPase activity
I6H70_RS06255	COG0590	tRNA wobble adenosine to inosine editing
I6H70_RS06265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H70_RS06265	COG0519	Catalyzes the synthesis of GMP from XMP
I6H70_RS06280	COG1570	exodeoxyribonuclease VII activity
I6H70_RS06285	COG0739	heme binding
I6H70_RS06290	COG1335	isochorismatase
I6H70_RS06295	COG0668	transmembrane transport
I6H70_RS06310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H70_RS06315	COG1064	alcohol dehydrogenase
I6H70_RS06325	COG2356	endonuclease I
I6H70_RS06330	COG3647	Membrane
I6H70_RS06350	COG0436	Aminotransferase
I6H70_RS06355	COG1160	GTP binding
I6H70_RS06370	COG0124	histidyl-tRNA synthetase
I6H70_RS06375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H70_RS06380	COG1426	Protein conserved in bacteria
I6H70_RS06390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H70_RS06395	COG0105	UTP biosynthetic process
I6H70_RS06410	COG0443	Heat shock 70 kDa protein
I6H70_RS06415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6H70_RS06420	COG0316	Belongs to the HesB IscA family
I6H70_RS06430	COG1104	cysteine desulfurase activity
I6H70_RS06455	COG3134	Outer membrane lipoprotein
I6H70_RS06470	COG1862	Preprotein translocase
I6H70_RS06480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H70_RS06490	COG1278	Cold shock
I6H70_RS06500	COG0795	lipopolysaccharide-transporting ATPase activity
I6H70_RS06505	COG0795	lipopolysaccharide-transporting ATPase activity
I6H70_RS06510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H70_RS06540	COG0471	metal ion transport
I6H70_RS06540	COG0490	domain, Protein
I6H70_RS06545	COG0477	Major facilitator Superfamily
I6H70_RS06550	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6H70_RS06565	COG3081	Nucleoid-associated protein
I6H70_RS06570	COG2326	polyphosphate kinase activity
I6H70_RS06590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6H70_RS06595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H70_RS06605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H70_RS06610	COG0583	DNA-binding transcription factor activity
I6H70_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS06620	COG0656	L-ascorbic acid biosynthetic process
I6H70_RS06625	COG1280	lysine exporter protein (LysE YggA)
I6H70_RS06645	COG1462	curli production assembly transport component CsgG
I6H70_RS06665	COG1309	transcriptional regulator
I6H70_RS06675	COG4067	protein conserved in archaea
I6H70_RS06675	COG0189	ligase activity
I6H70_RS06690	COG4771	TonB-dependent receptor
I6H70_RS06695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H70_RS06700	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H70_RS06705	COG1120	ATPase activity
I6H70_RS06745	COG3675	Pfam Lipase (class 3)
I6H70_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS06750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H70_RS06750	COG0318	PFAM AMP-dependent synthetase and ligase
I6H70_RS06750	COG0300	oxidoreductase activity
I6H70_RS06750	COG3321	synthase
I6H70_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS06770	COG3433	isochorismatase activity
I6H70_RS06770	COG1535	isochorismatase
I6H70_RS06775	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H70_RS06780	COG1169	isochorismate synthase
I6H70_RS06815	COG3845	ABC transporter
I6H70_RS06820	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H70_RS06825	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H70_RS06865	COG0402	S-adenosylhomocysteine deaminase activity
I6H70_RS06870	COG1802	Transcriptional regulator
I6H70_RS06875	COG2252	PERMEase
I6H70_RS06900	COG4266	Belongs to the allantoicase family
I6H70_RS06905	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6H70_RS06920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H70_RS06920	COG4651	solute:proton antiporter activity
I6H70_RS06930	COG0840	transmembrane signaling receptor activity
I6H70_RS06935	COG1309	transcriptional regulator
I6H70_RS06965	COG2351	hydroxyisourate hydrolase activity
I6H70_RS06970	COG0583	DNA-binding transcription factor activity
I6H70_RS06975	COG3960	tartronate-semialdehyde synthase activity
I6H70_RS06980	COG3622	Belongs to the hyi family
I6H70_RS06985	COG2084	Dehydrogenase
I6H70_RS06995	COG0469	pyruvate kinase activity
I6H70_RS07010	COG1017	nitric oxide dioxygenase activity
I6H70_RS07010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H70_RS07025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H70_RS07030	COG3706	GGDEF domain
I6H70_RS07045	COG0583	DNA-binding transcription factor activity
I6H70_RS07060	COG3300	MHYT domain
I6H70_RS07060	COG5001	Diguanylate cyclase
I6H70_RS07070	COG1704	LemA family
I6H70_RS07105	COG0459	protein refolding
I6H70_RS07110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H70_RS07115	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6H70_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS07145	COG0668	transmembrane transport
I6H70_RS07150	COG1666	GTP binding
I6H70_RS07155	COG0745	RESPONSE REGULATOR receiver
I6H70_RS07170	COG2096	Adenosyltransferase
I6H70_RS07200	COG0494	nUDIX hydrolase
I6H70_RS07205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H70_RS07210	COG0653	protein targeting
I6H70_RS07250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H70_RS07255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H70_RS07270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H70_RS07275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H70_RS07285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H70_RS07290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6H70_RS07300	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6H70_RS07305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H70_RS07325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H70_RS07340	COG0582	viral genome integration into host DNA
I6H70_RS07375	COG1205	dead DEAH box helicase
I6H70_RS07375	COG1111	helicase
I6H70_RS07380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H70_RS07490	COG4372	Transposase
I6H70_RS07515	COG4294	response to UV
I6H70_RS07520	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS07525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H70_RS07530	COG1024	Enoyl-CoA hydratase
I6H70_RS07550	COG0789	Transcriptional regulator
I6H70_RS07565	COG0288	reversible hydration of carbon dioxide
I6H70_RS07570	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6H70_RS07585	COG0456	acetyltransferase
I6H70_RS07595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H70_RS07605	COG0019	diaminopimelate decarboxylase activity
I6H70_RS07625	COG3008	intermembrane lipid transfer
I6H70_RS07630	COG2995	paraquat-inducible protein a
I6H70_RS07635	COG2995	paraquat-inducible protein a
I6H70_RS07665	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6H70_RS07670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6H70_RS07675	COG1183	phosphatidylcholine synthase activity
I6H70_RS07680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H70_RS07690	COG0028	Belongs to the TPP enzyme family
I6H70_RS07710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H70_RS07720	COG2226	methyltransferase
I6H70_RS07750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H70_RS07765	COG2264	protein methyltransferase activity
I6H70_RS07785	COG0138	bifunctional purine biosynthesis protein purh
I6H70_RS07800	COG2124	cytochrome p450
I6H70_RS07815	COG0679	Auxin Efflux Carrier
I6H70_RS07830	COG0436	Aminotransferase
I6H70_RS07835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6H70_RS07840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H70_RS07850	COG3852	Histidine kinase
I6H70_RS07855	COG2204	response regulator
I6H70_RS07870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6H70_RS07875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H70_RS07880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6H70_RS07885	COG0166	Belongs to the GPI family
I6H70_RS07915	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H70_RS07920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H70_RS07925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H70_RS07930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H70_RS07935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H70_RS07940	COG0195	Participates in both transcription termination and antitermination
I6H70_RS07945	COG0779	Required for maturation of 30S ribosomal subunits
I6H70_RS07965	COG0149	triose-phosphate isomerase activity
I6H70_RS07970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H70_RS07975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H70_RS07985	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6H70_RS08010	COG0505	Belongs to the CarA family
I6H70_RS08015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H70_RS08020	COG0484	heat shock protein binding
I6H70_RS08025	COG0443	Heat shock 70 kDa protein
I6H70_RS08030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H70_RS08035	COG0497	DNA recombination
I6H70_RS08045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H70_RS08055	COG3256	nitric oxide reductase
I6H70_RS08060	COG2010	Cytochrome c
I6H70_RS08065	COG0517	IMP dehydrogenase activity
I6H70_RS08065	COG0516	GMP reductase activity
I6H70_RS08080	COG2814	Major facilitator Superfamily
I6H70_RS08095	COG0672	)-iron permease
I6H70_RS08115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H70_RS08115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H70_RS08130	COG3154	lipid carrier protein
I6H70_RS08135	COG0826	peptidase U32
I6H70_RS08140	COG0826	peptidase U32
I6H70_RS08150	COG3604	Transcriptional regulator
I6H70_RS08155	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6H70_RS08175	COG4774	siderophore transport
I6H70_RS08180	COG3128	pkhd-type hydroxylase
I6H70_RS08190	COG0019	diaminopimelate decarboxylase activity
I6H70_RS08195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H70_RS08205	COG4993	Dehydrogenase
I6H70_RS08210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H70_RS08210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H70_RS08210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6H70_RS08215	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H70_RS08220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H70_RS08220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H70_RS08235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6H70_RS08265	COG0534	Mate efflux family protein
I6H70_RS08275	COG1166	arginine decarboxylase activity
I6H70_RS08280	COG0023	Translation Initiation Factor
I6H70_RS08285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H70_RS08330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H70_RS08335	COG1047	Peptidyl-prolyl cis-trans
I6H70_RS08345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H70_RS08350	COG0196	riboflavin kinase activity
I6H70_RS08355	COG0728	peptidoglycan biosynthetic process
I6H70_RS08360	COG0268	Binds directly to 16S ribosomal RNA
I6H70_RS08365	COG3045	CreA protein
I6H70_RS08370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H70_RS08375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H70_RS08380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H70_RS08385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H70_RS08390	COG0142	geranyltranstransferase activity
I6H70_RS08400	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H70_RS08410	COG2862	Uncharacterized protein family, UPF0114
I6H70_RS08420	COG1067	ATP-dependent peptidase activity
I6H70_RS08430	COG1970	mechanosensitive ion channel activity
I6H70_RS08435	COG2841	Protein conserved in bacteria
I6H70_RS08455	COG2020	methyltransferase activity
I6H70_RS08460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H70_RS08465	COG0488	(ABC) transporter
I6H70_RS08500	COG2813	Specifically methylates the guanine in position
I6H70_RS08505	COG0789	Transcriptional regulator
I6H70_RS08520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H70_RS08525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6H70_RS08530	COG2080	2 iron, 2 sulfur cluster binding
I6H70_RS08535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H70_RS08535	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H70_RS08555	COG2252	PERMEase
I6H70_RS08560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H70_RS08575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H70_RS08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H70_RS08610	COG1368	sulfuric ester hydrolase activity
I6H70_RS08620	COG3642	lipopolysaccharide core region biosynthetic process
I6H70_RS08640	COG1368	sulfuric ester hydrolase activity
I6H70_RS08700	COG3038	cytochrome b561
I6H70_RS08710	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H70_RS08725	COG2181	nitrate reductase activity
I6H70_RS08730	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6H70_RS08735	COG1140	nitrate reductase beta subunit
I6H70_RS08740	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6H70_RS08745	COG2223	nitrite transmembrane transporter activity
I6H70_RS08755	COG3850	Histidine kinase
I6H70_RS08760	COG2197	response regulator
I6H70_RS08780	COG2321	neutral zinc metallopeptidase
I6H70_RS08790	COG1946	Acyl-CoA thioesterase
I6H70_RS08795	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6H70_RS08805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H70_RS08805	COG2169	Transcriptional regulator
I6H70_RS08815	COG0084	hydrolase, TatD family'
I6H70_RS08830	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H70_RS08835	COG1515	deoxyribonuclease V activity
I6H70_RS08840	COG4977	sequence-specific DNA binding
I6H70_RS08845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6H70_RS08855	COG2945	thiolester hydrolase activity
I6H70_RS08880	COG1252	NADH dehydrogenase
I6H70_RS08950	COG1032	radical SAM domain protein
I6H70_RS08960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H70_RS08965	COG0305	Participates in initiation and elongation during chromosome replication
I6H70_RS08970	COG0359	binds to the 23S rRNA
I6H70_RS08980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H70_RS08985	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H70_RS08995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H70_RS09000	COG0557	exoribonuclease II activity
I6H70_RS09030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H70_RS09035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6H70_RS09040	COG0330	HflC and HflK could
I6H70_RS09045	COG0330	HflC and HflK could
I6H70_RS09050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H70_RS09055	COG1923	regulation of RNA biosynthetic process
I6H70_RS09060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H70_RS09065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H70_RS09070	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H70_RS09075	COG0802	atpase or kinase
I6H70_RS09080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H70_RS09080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H70_RS09105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H70_RS09115	COG0531	amino acid
I6H70_RS09120	COG4303	Ethanolamine ammonia lyase large subunit
I6H70_RS09135	COG3228	Belongs to the MtfA family
I6H70_RS09145	COG0582	viral genome integration into host DNA
I6H70_RS09185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H70_RS09255	COG0732	type I restriction modification DNA specificity domain
I6H70_RS09300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H70_RS09305	COG1335	isochorismatase
I6H70_RS09320	COG0459	protein refolding
I6H70_RS09345	COG3300	MHYT domain
I6H70_RS09345	COG5001	Diguanylate cyclase
I6H70_RS09350	COG0730	response to heat
I6H70_RS09355	COG1722	exodeoxyribonuclease VII activity
I6H70_RS09360	COG0142	geranyltranstransferase activity
I6H70_RS09365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H70_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS09405	COG4372	Transposase
I6H70_RS09420	COG1643	Atp-dependent helicase
I6H70_RS09450	COG1643	Atp-dependent helicase
I6H70_RS09500	COG2132	Multicopper oxidase
I6H70_RS09545	COG4372	Transposase
I6H70_RS09595	COG1765	OsmC-like protein
I6H70_RS09605	COG0134	indole-3-glycerol-phosphate synthase activity
I6H70_RS09610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H70_RS09615	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H70_RS09630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H70_RS09645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6H70_RS09650	COG3178	'Phosphotransferase
I6H70_RS09655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6H70_RS09660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H70_RS09665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6H70_RS09670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H70_RS09675	COG2967	ApaG domain
I6H70_RS09680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H70_RS09685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H70_RS09690	COG2766	serine protein kinase
I6H70_RS09695	COG2718	Belongs to the UPF0229 family
I6H70_RS09700	COG2719	SpoVR family
I6H70_RS09720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H70_RS09725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H70_RS09730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H70_RS09735	COG0358	DNA primase activity
I6H70_RS09740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H70_RS09770	COG4372	Transposase
I6H70_RS09810	COG5642	Protein of unknown function (DUF2384)
I6H70_RS09840	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS09860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H70_RS09865	COG2873	o-acetylhomoserine
I6H70_RS09870	COG3118	belongs to the thioredoxin family
I6H70_RS09900	COG0493	'glutamate synthase
I6H70_RS09905	COG0070	glutamate synthase
I6H70_RS09905	COG0069	glutamate synthase activity
I6H70_RS09905	COG0067	glutamate synthase
I6H70_RS09915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H70_RS09920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H70_RS09955	COG0281	malic enzyme
I6H70_RS09965	COG0254	rRNA binding
I6H70_RS09970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H70_RS09975	COG0018	arginyl-trna synthetase
I6H70_RS09990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6H70_RS10005	COG0248	Ppx GppA phosphatase
I6H70_RS10010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6H70_RS10020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6H70_RS10025	COG2050	protein possibly involved in aromatic compounds catabolism
I6H70_RS10035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H70_RS10065	COG3039	Transposase
I6H70_RS10070	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS10080	COG0642	Histidine kinase
I6H70_RS10100	COG2814	Major facilitator Superfamily
I6H70_RS10120	COG1238	metal cluster binding
I6H70_RS10130	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS10185	COG1671	Belongs to the UPF0178 family
I6H70_RS10190	COG1280	lysine exporter protein (LysE YggA)
I6H70_RS10195	COG0861	Integral membrane protein TerC family
I6H70_RS10205	COG0488	(ABC) transporter
I6H70_RS10225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6H70_RS10245	COG0181	hydroxymethylbilane synthase activity
I6H70_RS10255	COG2972	Histidine kinase
I6H70_RS10260	COG0165	Argininosuccinate lyase
I6H70_RS10305	COG3072	Adenylate cyclase
I6H70_RS10310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H70_RS10315	COG1965	Belongs to the frataxin family
I6H70_RS10330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H70_RS10340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6H70_RS10355	COG0432	Pfam Uncharacterised protein family UPF0047
I6H70_RS10360	COG0004	ammonium transporteR
I6H70_RS10365	COG0004	ammonium transporteR
I6H70_RS10370	COG0347	Belongs to the P(II) protein family
I6H70_RS10375	COG2960	long-chain fatty acid transporting porin activity
I6H70_RS10380	COG0606	chelatase, subunit chli
I6H70_RS10385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H70_RS10395	COG0210	DNA helicase
I6H70_RS10400	COG1272	protein, Hemolysin III
I6H70_RS10405	COG1414	Transcriptional regulator
I6H70_RS10415	COG1454	alcohol dehydrogenase
I6H70_RS10435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H70_RS10460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H70_RS10470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H70_RS10475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H70_RS10490	COG0840	transmembrane signaling receptor activity
I6H70_RS10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H70_RS10505	COG2003	Belongs to the UPF0758 family
I6H70_RS10510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H70_RS10515	COG0756	dUTP diphosphatase activity
I6H70_RS10525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H70_RS10540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H70_RS10545	COG0708	Exodeoxyribonuclease III
I6H70_RS10555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6H70_RS10560	COG1561	YicC-like family, N-terminal region
I6H70_RS10570	COG1758	RNA polymerase activity
I6H70_RS10575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H70_RS10605	COG2885	chlorophyll binding
I6H70_RS10615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H70_RS10630	COG1704	LemA family
I6H70_RS10635	COG0583	DNA-binding transcription factor activity
I6H70_RS10640	COG0604	alcohol dehydrogenase
I6H70_RS10650	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS10655	COG0583	DNA-binding transcription factor activity
I6H70_RS10680	COG1620	l-lactate permease
I6H70_RS10685	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6H70_RS10690	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6H70_RS10695	COG0247	lactate metabolic process
I6H70_RS10700	COG0277	FAD linked oxidase domain protein
I6H70_RS10705	COG0277	FAD linked oxidase domain protein
I6H70_RS10710	COG2186	Transcriptional regulator
I6H70_RS10725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6H70_RS10740	COG1253	flavin adenine dinucleotide binding
I6H70_RS10745	COG0739	heme binding
I6H70_RS10750	COG0745	RESPONSE REGULATOR receiver
I6H70_RS10760	COG1192	Involved in chromosome partitioning
I6H70_RS10780	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H70_RS10790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H70_RS10795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H70_RS10800	COG0730	response to heat
I6H70_RS10810	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6H70_RS10815	COG0494	nUDIX hydrolase
I6H70_RS10830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H70_RS10835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H70_RS10850	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H70_RS10855	COG0277	FAD linked oxidase domain protein
I6H70_RS10860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H70_RS10875	COG2197	response regulator
I6H70_RS10900	COG0651	ATP synthesis coupled electron transport
I6H70_RS10905	COG1007	ATP synthesis coupled electron transport
I6H70_RS10920	COG1320	monovalent cation:proton antiporter activity
I6H70_RS10985	COG0543	2 iron, 2 sulfur cluster binding
I6H70_RS11000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6H70_RS11015	COG4372	Transposase
I6H70_RS11090	COG1217	gtp-binding protein TYPA
I6H70_RS11095	COG0301	tRNA thio-modification
I6H70_RS11095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H70_RS11115	COG3852	Histidine kinase
I6H70_RS11120	COG2204	response regulator
I6H70_RS11130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H70_RS11140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6H70_RS11155	COG2226	methyltransferase
I6H70_RS11165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6H70_RS11170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6H70_RS11175	COG0140	phosphoribosyl-ATP diphosphatase activity
I6H70_RS11180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H70_RS11185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H70_RS11205	COG1490	D-aminoacyl-tRNA deacylase activity
I6H70_RS11220	COG3040	lipid binding
I6H70_RS11225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H70_RS11235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6H70_RS11240	COG0058	SHG alpha-glucan phosphorylase activity
I6H70_RS11270	COG2233	PERMEase
I6H70_RS11305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H70_RS11310	COG0581	inorganic phosphate transmembrane transporter activity
I6H70_RS11330	COG5002	protein histidine kinase activity
I6H70_RS11330	COG5001	Diguanylate cyclase
I6H70_RS11330	COG3447	MASE1 domain protein
I6H70_RS11345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H70_RS11350	COG1074	ATP-dependent DNA helicase activity
I6H70_RS11355	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6H70_RS11365	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H70_RS11375	COG2358	TRAP transporter, solute receptor (TAXI family
I6H70_RS11380	COG0840	transmembrane signaling receptor activity
I6H70_RS11390	COG0840	transmembrane signaling receptor activity
I6H70_RS11425	COG3180	Ammonia monooxygenase
I6H70_RS11430	COG0700	Nucleoside recognition
I6H70_RS11450	COG2204	response regulator
I6H70_RS11455	COG5002	protein histidine kinase activity
I6H70_RS11465	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H70_RS11490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H70_RS11495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H70_RS11495	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H70_RS11510	COG1178	ABC-type Fe3 transport system permease component
I6H70_RS11520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H70_RS11525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H70_RS11530	COG0006	proline dipeptidase activity
I6H70_RS11535	COG3079	Belongs to the UPF0149 family
I6H70_RS11555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H70_RS11575	COG0604	alcohol dehydrogenase
I6H70_RS11580	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6H70_RS11595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6H70_RS11600	COG4942	peptidase
I6H70_RS11605	COG0793	Belongs to the peptidase S41A family
I6H70_RS11610	COG2861	carbohydrate metabolic process
I6H70_RS11620	COG0330	HflC and HflK could
I6H70_RS11630	COG0107	imidazoleglycerol-phosphate synthase activity
I6H70_RS11635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6H70_RS11650	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H70_RS11665	COG1194	a g-specific adenine glycosylase
I6H70_RS11670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6H70_RS11690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H70_RS11700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H70_RS11715	COG0676	glucose-6-phosphate 1-epimerase activity
I6H70_RS11775	COG3706	GGDEF domain
I6H70_RS11785	COG4191	Histidine kinase
I6H70_RS11790	COG0745	RESPONSE REGULATOR receiver
I6H70_RS11795	COG5002	protein histidine kinase activity
I6H70_RS11800	COG0745	RESPONSE REGULATOR receiver
I6H70_RS11810	COG5002	protein histidine kinase activity
I6H70_RS11815	COG0745	RESPONSE REGULATOR receiver
I6H70_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
I6H70_RS11840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H70_RS11845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H70_RS11870	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS11875	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS11880	COG1024	Enoyl-CoA hydratase
I6H70_RS11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H70_RS11885	COG0745	RESPONSE REGULATOR receiver
I6H70_RS11895	COG3909	cytochrome
I6H70_RS11915	COG2204	response regulator
I6H70_RS11920	COG4191	Histidine kinase
I6H70_RS11930	COG0659	secondary active sulfate transmembrane transporter activity
I6H70_RS11935	COG0589	response to stress
I6H70_RS11940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H70_RS11950	COG0509	glycine decarboxylation via glycine cleavage system
I6H70_RS11960	COG1309	transcriptional regulator
I6H70_RS11985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H70_RS11995	COG1335	isochorismatase
I6H70_RS12025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H70_RS12040	COG0668	transmembrane transport
I6H70_RS12050	COG4770	biotin carboxylase activity
I6H70_RS12075	COG3276	selenocysteine insertion sequence binding
I6H70_RS12080	COG1921	L-seryl-tRNASec selenium transferase activity
I6H70_RS12085	COG3058	Necessary for formate dehydrogenase activity
I6H70_RS12090	COG2864	formate dehydrogenase
I6H70_RS12095	COG0437	4 iron, 4 sulfur cluster binding
I6H70_RS12110	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H70_RS12115	COG0210	DNA helicase
I6H70_RS12120	COG5001	Diguanylate cyclase
I6H70_RS12120	COG3300	MHYT domain
I6H70_RS12130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H70_RS12135	COG0583	DNA-binding transcription factor activity
I6H70_RS12140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H70_RS12190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H70_RS12195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6H70_RS12200	COG2207	Transcriptional regulator
I6H70_RS12235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6H70_RS12240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H70_RS12275	COG0109	protoheme IX farnesyltransferase activity
I6H70_RS12290	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H70_RS12315	COG2706	6-phosphogluconolactonase activity
I6H70_RS12320	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS12325	COG0784	Response regulator, receiver
I6H70_RS12325	COG4191	Histidine kinase
I6H70_RS12345	COG3360	Dodecin
I6H70_RS12350	COG4249	Peptidase C14 caspase catalytic subunit p20
I6H70_RS12355	COG1132	(ABC) transporter
I6H70_RS12375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H70_RS12380	COG2010	Cytochrome c
I6H70_RS12395	COG0133	tryptophan synthase activity
I6H70_RS12400	COG0159	tryptophan synthase activity
I6H70_RS12420	COG3550	peptidyl-serine autophosphorylation
I6H70_RS12425	COG1396	sequence-specific DNA binding
I6H70_RS12430	COG0625	glutathione transferase activity
I6H70_RS12455	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS12465	COG2323	membrane
I6H70_RS12470	COG2814	Major facilitator Superfamily
I6H70_RS12475	COG0583	DNA-binding transcription factor activity
I6H70_RS12495	COG1686	Belongs to the peptidase S11 family
I6H70_RS12510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H70_RS12530	COG0408	coproporphyrinogen oxidase activity
I6H70_RS12540	COG0009	L-threonylcarbamoyladenylate synthase
I6H70_RS12545	COG0758	DNA mediated transformation
I6H70_RS12555	COG0242	peptide deformylase activity
I6H70_RS12560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H70_RS12565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H70_RS12570	COG0569	domain protein
I6H70_RS12575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H70_RS12580	COG0765	amino acid transport
I6H70_RS12585	COG0765	amino acid transport
I6H70_RS12590	COG1126	abc transporter atp-binding protein
I6H70_RS12610	COG2818	Glycosylase
I6H70_RS12620	COG0751	glycine-tRNA ligase activity
I6H70_RS12635	COG3706	GGDEF domain
I6H70_RS12650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H70_RS12660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H70_RS12665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H70_RS12670	COG0594	ribonuclease P activity
I6H70_RS12675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H70_RS12680	COG0706	membrane insertase activity
I6H70_RS12685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H70_RS12690	COG0445	tRNA wobble uridine modification
I6H70_RS12695	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H70_RS12700	COG1192	Involved in chromosome partitioning
I6H70_RS12705	COG1475	DNA binding
I6H70_RS12710	COG3312	ion transport
I6H70_RS12715	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H70_RS12725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H70_RS12730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H70_RS12735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H70_RS12740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H70_RS12745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H70_RS12750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H70_RS12755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H70_RS12760	COG1349	DNA-binding transcription factor activity
I6H70_RS12765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H70_RS12800	COG0071	Belongs to the small heat shock protein (HSP20) family
I6H70_RS12805	COG0542	response to heat
I6H70_RS12815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H70_RS12845	COG0501	Belongs to the peptidase M48B family
I6H70_RS12850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H70_RS12870	COG4251	negative regulation of phosphorylation
I6H70_RS12890	COG0523	cobalamin synthesis protein
I6H70_RS12915	COG2358	TRAP transporter, solute receptor (TAXI family
I6H70_RS12935	COG4221	oxidoreductase activity
I6H70_RS12955	COG0640	Transcriptional regulator
I6H70_RS12960	COG0431	NADPH-dependent FMN reductase
I6H70_RS12965	COG1742	UPF0060 membrane protein
I6H70_RS12970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H70_RS12985	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6H70_RS12990	COG3052	prosthetic group binding
I6H70_RS13010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H70_RS13040	COG2011	ABC-type metal ion transport system permease component
I6H70_RS13055	COG1451	nucleotide metabolic process
I6H70_RS13060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H70_RS13065	COG1121	(ABC) transporter
I6H70_RS13070	COG0735	belongs to the Fur family
I6H70_RS13135	COG0842	Transport permease protein
I6H70_RS13140	COG0842	Transport permease protein
I6H70_RS13140	COG1129	ABC transporter
I6H70_RS13145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H70_RS13160	COG1127	ABC transporter
I6H70_RS13165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H70_RS13175	COG3179	chitinase
I6H70_RS13200	COG1611	Belongs to the LOG family
I6H70_RS13210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H70_RS13225	COG1177	transmembrane transport
I6H70_RS13230	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H70_RS13235	COG3842	ATPase activity
I6H70_RS13255	COG0174	glutamine synthetase
I6H70_RS13260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H70_RS13265	COG0174	glutamine synthetase
I6H70_RS13280	COG2957	Belongs to the agmatine deiminase family
I6H70_RS13315	COG0631	protein serine/threonine phosphatase activity
I6H70_RS13380	COG0583	DNA-binding transcription factor activity
I6H70_RS13445	COG0826	peptidase U32
I6H70_RS13450	COG2841	Protein conserved in bacteria
I6H70_RS13455	COG0527	aspartate kinase activity
I6H70_RS13460	COG5285	phytanoyl-CoA dioxygenase
I6H70_RS13465	COG1917	Cupin 2, conserved barrel domain protein
I6H70_RS13470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6H70_RS13480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H70_RS13485	COG0837	glucose binding
I6H70_RS13485	COG1737	Transcriptional regulator
I6H70_RS13495	COG0583	DNA-binding transcription factor activity
I6H70_RS13500	COG0439	Biotin carboxylase
I6H70_RS13505	COG5016	pyruvate
I6H70_RS13505	COG0511	ligase activity, forming carbon-carbon bonds
I6H70_RS13520	COG2066	Belongs to the glutaminase family
I6H70_RS13530	COG0252	asparaginase activity
I6H70_RS13535	COG1115	amino acid carrier protein
I6H70_RS13560	COG1301	dicarboxylic acid transport
I6H70_RS13570	COG0583	DNA-binding transcription factor activity
I6H70_RS13580	COG1082	Xylose isomerase domain protein TIM barrel
I6H70_RS13580	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6H70_RS13585	COG2205	protein histidine kinase activity
I6H70_RS13620	COG0604	alcohol dehydrogenase
I6H70_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS13620	COG3321	synthase
I6H70_RS13625	COG2130	NADP-dependent
I6H70_RS13635	COG0058	SHG alpha-glucan phosphorylase activity
I6H70_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS13655	COG2610	gluconate transmembrane transporter activity
I6H70_RS13670	COG0586	Pfam SNARE associated Golgi protein
I6H70_RS13695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H70_RS13700	COG1764	response to oxidative stress
I6H70_RS13715	COG2989	Protein conserved in bacteria
I6H70_RS13725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H70_RS13735	COG1392	Phosphate transport regulator
I6H70_RS13740	COG0306	phosphate transporter
I6H70_RS13750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H70_RS13750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6H70_RS13755	COG2918	glutathione biosynthetic process
I6H70_RS13765	COG2183	response to ionizing radiation
I6H70_RS13770	COG0457	Tetratricopeptide repeat
I6H70_RS13770	COG3118	belongs to the thioredoxin family
I6H70_RS13775	COG1215	transferase activity, transferring glycosyl groups
I6H70_RS13780	COG1215	transferase activity, transferring glycosyl groups
I6H70_RS13795	COG2194	sulfuric ester hydrolase activity
I6H70_RS13825	COG0189	ligase activity
I6H70_RS13830	COG4067	protein conserved in archaea
I6H70_RS13830	COG0189	ligase activity
I6H70_RS13835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H70_RS13850	COG0778	Nitroreductase
I6H70_RS13870	COG0019	diaminopimelate decarboxylase activity
I6H70_RS13885	COG0747	negative chemotaxis
I6H70_RS13915	COG1024	Enoyl-CoA hydratase
I6H70_RS13915	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H70_RS13920	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS13925	COG1454	alcohol dehydrogenase
I6H70_RS13930	COG0824	Thioesterase
I6H70_RS13940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H70_RS13945	COG4191	Histidine kinase
I6H70_RS13945	COG0784	Response regulator, receiver
I6H70_RS13950	COG1011	Hydrolase
I6H70_RS13955	COG0494	nUDIX hydrolase
I6H70_RS13960	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6H70_RS13965	COG2233	PERMEase
I6H70_RS13980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H70_RS13985	COG0693	protein deglycase activity
I6H70_RS13995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H70_RS14015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H70_RS14020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H70_RS14025	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6H70_RS14045	COG0429	hydrolase of the alpha beta-hydrolase fold
I6H70_RS14055	COG0742	ribosomal rna small subunit methyltransferase
I6H70_RS14060	COG0612	Peptidase, M16
I6H70_RS14065	COG0612	Peptidase, M16
I6H70_RS14070	COG0552	protein localization to endoplasmic reticulum
I6H70_RS14075	COG2884	Cell division ATP-binding protein ftsE
I6H70_RS14080	COG2177	Part of the ABC transporter FtsEX involved in
I6H70_RS14090	COG5002	protein histidine kinase activity
I6H70_RS14100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H70_RS14105	COG2363	Small membrane protein
I6H70_RS14115	COG2022	thiamine diphosphate biosynthetic process
I6H70_RS14120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H70_RS14140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H70_RS14155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H70_RS14155	COG2813	Specifically methylates the guanine in position
I6H70_RS14160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H70_RS14215	COG0540	Belongs to the ATCase OTCase family
I6H70_RS14220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H70_RS14225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H70_RS14230	COG1678	Uncharacterized ACR, COG1678
I6H70_RS14270	COG0643	Histidine kinase
I6H70_RS14270	COG2198	Histidine kinase
I6H70_RS14270	COG0784	Response regulator, receiver
I6H70_RS14275	COG2201	protein-glutamate methylesterase activity
I6H70_RS14285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H70_RS14295	COG3038	cytochrome b561
I6H70_RS14300	COG2353	YceI-like domain
I6H70_RS14305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H70_RS14325	COG0513	Belongs to the DEAD box helicase family
I6H70_RS14330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H70_RS14335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6H70_RS14355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H70_RS14360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H70_RS14365	COG1131	(ABC) transporter
I6H70_RS14370	COG0842	Transport permease protein
I6H70_RS14390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H70_RS14395	COG2226	methyltransferase
I6H70_RS14405	COG2175	clavaminate synthase activity
I6H70_RS14410	COG0583	DNA-binding transcription factor activity
I6H70_RS14415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H70_RS14420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H70_RS14425	COG0126	phosphoglycerate kinase activity
I6H70_RS14440	COG0191	fructose-bisphosphate aldolase activity
I6H70_RS14480	COG2081	HI0933 family
I6H70_RS14485	COG1289	transmembrane transporter activity
I6H70_RS14500	COG0513	Belongs to the DEAD box helicase family
I6H70_RS14515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H70_RS14585	COG4999	Histidine kinase
I6H70_RS14585	COG3850	Histidine kinase
I6H70_RS14585	COG3437	response regulator, receiver
I6H70_RS14585	COG2205	protein histidine kinase activity
I6H70_RS14590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6H70_RS14600	COG0784	Response regulator, receiver
I6H70_RS14600	COG2205	protein histidine kinase activity
I6H70_RS14610	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6H70_RS14615	COG1196	nuclear chromosome segregation
I6H70_RS14615	COG3264	Mechanosensitive ion channel
I6H70_RS14620	COG3263	regulation of cellular component size
I6H70_RS14625	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS14640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6H70_RS14645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6H70_RS14655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H70_RS14660	COG0156	8-amino-7-oxononanoate synthase activity
I6H70_RS14665	COG1073	alpha beta
I6H70_RS14665	COG2226	methyltransferase
I6H70_RS14685	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS14695	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS14705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H70_RS14740	COG0859	PFAM glycosyl transferase family 9
I6H70_RS14745	COG0859	PFAM glycosyl transferase family 9
I6H70_RS14750	COG0438	transferase activity, transferring glycosyl groups
I6H70_RS14775	COG2192	nodulation
I6H70_RS14780	COG0438	transferase activity, transferring glycosyl groups
I6H70_RS14795	COG0297	glycogen (starch) synthase activity
I6H70_RS14815	COG1132	(ABC) transporter
I6H70_RS14830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6H70_RS14830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H70_RS14855	COG1519	Transferase
I6H70_RS14860	COG1538	Outer membrane efflux protein
I6H70_RS14865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H70_RS14880	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H70_RS14975	COG2165	general secretion pathway protein
I6H70_RS14985	COG1459	type II secretion system
I6H70_RS14990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H70_RS15000	COG0730	response to heat
I6H70_RS15010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H70_RS15025	COG0494	nUDIX hydrolase
I6H70_RS15035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H70_RS15040	COG3150	esterase
I6H70_RS15055	COG3577	Aspartyl protease
I6H70_RS15075	COG0560	Phosphoserine phosphatase
I6H70_RS15075	COG3830	Belongs to the UPF0237 family
I6H70_RS15080	COG1063	alcohol dehydrogenase
I6H70_RS15085	COG2200	EAL domain
I6H70_RS15095	COG0688	phosphatidylethanolamine metabolic process
I6H70_RS15110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6H70_RS15115	COG1360	Flagellar Motor Protein
I6H70_RS15120	COG1162	GTPase activity
I6H70_RS15130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6H70_RS15135	COG0702	epimerase
I6H70_RS15155	COG1346	cytolysis
I6H70_RS15165	COG0586	Pfam SNARE associated Golgi protein
I6H70_RS15170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H70_RS15175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H70_RS15185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6H70_RS15190	COG0768	penicillin binding
I6H70_RS15195	COG0772	Belongs to the SEDS family
I6H70_RS15200	COG2951	lytic endotransglycosylase activity
I6H70_RS15210	COG1686	Belongs to the peptidase S11 family
I6H70_RS15215	COG2921	Belongs to the UPF0250 family
I6H70_RS15220	COG0321	lipoyl(octanoyl) transferase activity
I6H70_RS15225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H70_RS15240	COG2951	lytic endotransglycosylase activity
I6H70_RS15255	COG0495	leucyl-tRNA aminoacylation
I6H70_RS15270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6H70_RS15275	COG4535	Mg2 and Co2 transporter CorC
I6H70_RS15280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H70_RS15285	COG1702	phosphate starvation-inducible protein PhoH
I6H70_RS15290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H70_RS15305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H70_RS15315	COG0351	phosphomethylpyrimidine kinase
I6H70_RS15330	COG1203	CRISPR-associated helicase, Cas3
I6H70_RS15345	COG1857	crispr-associated protein
I6H70_RS15365	COG1518	maintenance of DNA repeat elements
I6H70_RS15370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H70_RS15375	COG0427	acetyl-CoA hydrolase
I6H70_RS15380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H70_RS15385	COG4993	Dehydrogenase
I6H70_RS15400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6H70_RS15405	COG0830	nickel cation binding
I6H70_RS15420	COG0697	spore germination
I6H70_RS15425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6H70_RS15435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6H70_RS15440	COG0804	urea catabolic process
I6H70_RS15445	COG0832	Belongs to the urease beta subunit family
I6H70_RS15455	COG0831	urea catabolic process
I6H70_RS15460	COG0829	nickel cation binding
I6H70_RS15510	COG1522	sequence-specific DNA binding
I6H70_RS15520	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6H70_RS15525	COG0537	adenosine 5'-monophosphoramidase activity
I6H70_RS15540	COG1981	membrane
I6H70_RS15545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6H70_RS15550	COG0316	Belongs to the HesB IscA family
I6H70_RS15560	COG0739	heme binding
I6H70_RS15595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H70_RS15595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H70_RS15600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6H70_RS15625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H70_RS15650	COG0081	regulation of translation
I6H70_RS15665	COG0085	RNA polymerase activity
I6H70_RS15670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H70_RS15675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H70_RS15680	COG0049	tRNA binding
I6H70_RS15690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H70_RS15700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H70_RS15705	COG0088	Forms part of the polypeptide exit tunnel
I6H70_RS15710	COG0089	rRNA binding
I6H70_RS15715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H70_RS15720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H70_RS15725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H70_RS15730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H70_RS15735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H70_RS15740	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H70_RS15750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H70_RS15755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H70_RS15760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H70_RS15765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H70_RS15770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H70_RS15775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H70_RS15785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H70_RS15790	COG1841	ribosomal large subunit assembly
I6H70_RS15795	COG0200	Binds to the 23S rRNA
I6H70_RS15805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H70_RS15810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H70_RS15815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H70_RS15820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H70_RS15825	COG0202	RNA polymerase activity
I6H70_RS15830	COG0203	ribosomal protein L17
I6H70_RS15835	COG0753	catalase activity
I6H70_RS15860	COG2814	Major facilitator Superfamily
I6H70_RS15875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H70_RS15880	COG3047	cAMP biosynthetic process
I6H70_RS15890	COG0811	peptide transport
I6H70_RS15895	COG0811	peptide transport
I6H70_RS15900	COG0848	biopolymer transport protein
I6H70_RS15940	COG3118	belongs to the thioredoxin family
I6H70_RS15945	COG2391	methyltransferase activity
I6H70_RS15950	COG0425	Belongs to the sulfur carrier protein TusA family
I6H70_RS15955	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6H70_RS15960	COG2264	protein methyltransferase activity
I6H70_RS15975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H70_RS15975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H70_RS15990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H70_RS15995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H70_RS16000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6H70_RS16005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H70_RS16010	COG3577	Aspartyl protease
I6H70_RS16015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H70_RS16030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H70_RS16045	COG4206	TonB-dependent receptor
I6H70_RS16050	COG0513	Belongs to the DEAD box helicase family
I6H70_RS16060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H70_RS16060	COG0493	'glutamate synthase
I6H70_RS16080	COG2217	Heavy metal translocating P-type atpase
I6H70_RS16095	COG2814	Major facilitator Superfamily
I6H70_RS16105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H70_RS16140	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H70_RS16145	COG1607	acyl-coa hydrolase
I6H70_RS16155	COG0402	S-adenosylhomocysteine deaminase activity
I6H70_RS16160	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6H70_RS16170	COG0174	glutamine synthetase
I6H70_RS16175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H70_RS16185	COG0420	3'-5' exonuclease activity
I6H70_RS16230	COG0564	pseudouridine synthase activity
I6H70_RS16240	COG1040	competence protein
I6H70_RS16245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6H70_RS16255	COG3829	transcription factor binding
I6H70_RS16255	COG3290	protein histidine kinase activity
I6H70_RS16260	COG2031	fatty acid transporter
I6H70_RS16275	COG1522	sequence-specific DNA binding
I6H70_RS16290	COG0733	neurotransmitter:sodium symporter activity
I6H70_RS16300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6H70_RS16310	COG0625	glutathione transferase activity
I6H70_RS16315	COG0733	neurotransmitter:sodium symporter activity
I6H70_RS16335	COG2819	hydrolase of the alpha beta superfamily
I6H70_RS16360	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6H70_RS16380	COG5002	protein histidine kinase activity
I6H70_RS16380	COG2198	Histidine kinase
I6H70_RS16380	COG0784	Response regulator, receiver
I6H70_RS16385	COG1760	l-serine dehydratase
I6H70_RS16390	COG0492	ferredoxin-NADP+ reductase activity
I6H70_RS16400	COG3189	MarR family transcriptional regulator
I6H70_RS16415	COG1960	acyl-CoA dehydrogenase activity
I6H70_RS16420	COG3901	Regulator of nitric oxide reductase transcription
I6H70_RS16420	COG0348	domain, Protein
I6H70_RS16425	COG4263	nitrous-oxide reductase activity
I6H70_RS16440	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6H70_RS16460	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS16470	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H70_RS16475	COG2239	Acts as a magnesium transporter
I6H70_RS16490	COG1648	precorrin-2 dehydrogenase activity
I6H70_RS16490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H70_RS16495	COG0535	radical SAM domain protein
I6H70_RS16505	COG1845	cytochrome c oxidase, subunit III
I6H70_RS16510	COG0714	Associated with various cellular activities
I6H70_RS16525	COG2010	Cytochrome c
I6H70_RS16530	COG3391	amine dehydrogenase activity
I6H70_RS16555	COG1737	Transcriptional regulator
I6H70_RS16570	COG0800	Aldolase
I6H70_RS16580	COG4989	oxidoreductase activity
I6H70_RS16585	COG2182	Extracellular solute-binding protein
I6H70_RS16595	COG4580	involved in the transport of maltose and maltodextrins
I6H70_RS16615	COG0366	Alpha amylase catalytic
I6H70_RS16625	COG1175	transmembrane transport
I6H70_RS16630	COG3833	ABC-type maltose transport systems, permease component
I6H70_RS16645	COG0366	Alpha amylase catalytic
I6H70_RS16650	COG3842	ATPase activity
I6H70_RS16660	COG1280	lysine exporter protein (LysE YggA)
I6H70_RS16665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6H70_RS16675	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS16685	COG1715	Restriction endonuclease
I6H70_RS16715	COG0247	lactate metabolic process
I6H70_RS16720	COG1620	l-lactate permease
I6H70_RS16730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H70_RS16740	COG2914	Belongs to the UPF0125 (RnfH) family
I6H70_RS16755	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6H70_RS16775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H70_RS16780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H70_RS16785	COG0154	amidase activity
I6H70_RS16795	COG1077	Cell shape determining protein MreB Mrl
I6H70_RS16800	COG1792	Involved in formation and maintenance of cell shape
I6H70_RS16815	COG1530	ribonuclease E activity
I6H70_RS16825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H70_RS16830	COG0312	modulator of DNA gyrase
I6H70_RS16840	COG0312	modulator of DNA gyrase
I6H70_RS16845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H70_RS16850	COG1660	Displays ATPase and GTPase activities
I6H70_RS16865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6H70_RS16870	COG1137	ATPase activity
I6H70_RS16875	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6H70_RS16885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6H70_RS16895	COG1127	ABC transporter
I6H70_RS16900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H70_RS16905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H70_RS16925	COG5007	Belongs to the BolA IbaG family
I6H70_RS16930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H70_RS16935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H70_RS16940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H70_RS16945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H70_RS16950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H70_RS16960	COG0175	sulfate reduction
I6H70_RS16990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6H70_RS16995	COG0237	dephospho-CoA kinase activity
I6H70_RS17010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H70_RS17015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H70_RS17020	COG0723	plastoquinol--plastocyanin reductase activity
I6H70_RS17025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6H70_RS17030	COG2857	Cytochrome c1
I6H70_RS17035	COG0625	glutathione transferase activity
I6H70_RS17040	COG2969	positive regulation of protein catabolic process
I6H70_RS17045	COG2823	Periplasmic or secreted lipoprotein
I6H70_RS17050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6H70_RS17055	COG0792	nuclease activity
I6H70_RS17080	COG0275	rRNA processing
I6H70_RS17095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H70_RS17100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H70_RS17105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H70_RS17110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H70_RS17115	COG0772	Belongs to the SEDS family
I6H70_RS17120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H70_RS17125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H70_RS17130	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H70_RS17145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H70_RS17165	COG1285	pathogenesis
I6H70_RS17190	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS17195	COG0659	secondary active sulfate transmembrane transporter activity
I6H70_RS17250	COG0501	Belongs to the peptidase M48B family
I6H70_RS17260	COG2119	membrane
I6H70_RS17265	COG2813	Specifically methylates the guanine in position
I6H70_RS17270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H70_RS17275	COG1280	lysine exporter protein (LysE YggA)
I6H70_RS17280	COG0318	PFAM AMP-dependent synthetase and ligase
I6H70_RS17285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H70_RS17290	COG2885	chlorophyll binding
I6H70_RS17295	COG0784	Response regulator, receiver
I6H70_RS17295	COG2205	protein histidine kinase activity
I6H70_RS17295	COG5002	protein histidine kinase activity
I6H70_RS17305	COG0204	Acyl-transferase
I6H70_RS17315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H70_RS17325	COG0386	Belongs to the glutathione peroxidase family
I6H70_RS17335	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6H70_RS17350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6H70_RS17395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H70_RS17400	COG0693	protein deglycase activity
I6H70_RS17445	COG0714	Associated with various cellular activities
I6H70_RS17465	COG2925	Exonuclease
I6H70_RS17475	COG0788	formyltetrahydrofolate deformylase activity
I6H70_RS17485	COG0433	COG0433 Predicted ATPase
I6H70_RS17500	COG3022	response to hydroperoxide
I6H70_RS17510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6H70_RS17515	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H70_RS17520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6H70_RS17540	COG3706	GGDEF domain
I6H70_RS17545	COG0400	carboxylic ester hydrolase activity
I6H70_RS17550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H70_RS17555	COG4597	amino acid ABC transporter
I6H70_RS17560	COG0765	amino acid transport
I6H70_RS17565	COG1126	abc transporter atp-binding protein
I6H70_RS17580	COG3034	peptidoglycan biosynthetic process
I6H70_RS17605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6H70_RS17610	COG4536	flavin adenine dinucleotide binding
I6H70_RS17615	COG4137	Cytochrome C assembly protein
I6H70_RS17620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H70_RS17625	COG0228	four-way junction DNA binding
I6H70_RS17630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H70_RS17635	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H70_RS17640	COG0335	large ribosomal subunit rRNA binding
I6H70_RS17665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H70_RS17670	COG0418	dihydroorotase activity
I6H70_RS17680	COG0137	argininosuccinate synthase activity
I6H70_RS17685	COG0346	lactoylglutathione lyase activity
I6H70_RS17695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H70_RS17705	COG4659	FMN binding
I6H70_RS17710	COG4658	electron transport chain
I6H70_RS17720	COG2878	Part of a membrane complex involved in electron transport
I6H70_RS17725	COG4657	Part of a membrane complex involved in electron transport
I6H70_RS17735	COG1024	Enoyl-CoA hydratase
I6H70_RS17745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H70_RS17760	COG0354	folic acid binding
I6H70_RS17795	COG0481	GTPase activity
I6H70_RS17810	COG0571	ribonuclease III activity
I6H70_RS17820	COG1381	Involved in DNA repair and RecF pathway recombination
I6H70_RS17825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6H70_RS17835	COG0583	DNA-binding transcription factor activity
I6H70_RS17845	COG0500	methyltransferase
I6H70_RS17850	COG2226	methyltransferase
I6H70_RS17860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H70_RS17875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H70_RS17895	COG0583	DNA-binding transcription factor activity
I6H70_RS17905	COG0583	DNA-binding transcription factor activity
I6H70_RS17940	COG3609	addiction module antidote protein, CC2985 family
I6H70_RS17975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H70_RS18105	COG1196	nuclear chromosome segregation
I6H70_RS18110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H70_RS18170	COG2003	Belongs to the UPF0758 family
I6H70_RS18250	COG0277	FAD linked oxidase domain protein
I6H70_RS18260	COG0582	viral genome integration into host DNA
I6H70_RS18280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H70_RS18280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H70_RS18285	COG0489	protein tyrosine kinase activity
I6H70_RS18290	COG1278	Cold shock
I6H70_RS18295	COG0717	Belongs to the dCTP deaminase family
I6H70_RS18330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H70_RS18335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H70_RS18350	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H70_RS18360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H70_RS18360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H70_RS18380	COG3639	organic phosphonate transmembrane transporter activity
I6H70_RS18390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6H70_RS18395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H70_RS18400	COG2084	Dehydrogenase
I6H70_RS18405	COG3622	Belongs to the hyi family
I6H70_RS18410	COG2271	Major facilitator Superfamily
I6H70_RS18415	COG0443	Heat shock 70 kDa protein
I6H70_RS18425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H70_RS18445	COG2030	dehydratase
I6H70_RS18450	COG0318	PFAM AMP-dependent synthetase and ligase
I6H70_RS18455	COG0318	PFAM AMP-dependent synthetase and ligase
I6H70_RS18470	COG1643	Atp-dependent helicase
I6H70_RS18475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H70_RS18495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H70_RS18505	COG1280	lysine exporter protein (LysE YggA)
I6H70_RS18515	COG1764	response to oxidative stress
I6H70_RS18520	COG4977	sequence-specific DNA binding
I6H70_RS18520	COG1917	Cupin 2, conserved barrel domain protein
I6H70_RS18560	COG0583	DNA-binding transcription factor activity
I6H70_RS18585	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS18600	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H70_RS18605	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H70_RS18610	COG0022	dehydrogenase e1 component
I6H70_RS18615	COG1063	alcohol dehydrogenase
I6H70_RS18620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H70_RS18635	COG3039	Transposase
I6H70_RS18640	COG3284	Transcriptional regulator
I6H70_RS18645	COG0784	Response regulator, receiver
I6H70_RS18645	COG4191	Histidine kinase
I6H70_RS18665	COG1234	tRNA 3'-trailer cleavage
I6H70_RS18670	COG0730	response to heat
I6H70_RS18685	COG2258	MOSC domain
I6H70_RS18695	COG0537	adenosine 5'-monophosphoramidase activity
I6H70_RS18710	COG1116	anion transmembrane transporter activity
I6H70_RS18715	COG2733	membrane
I6H70_RS18750	COG2814	Major facilitator Superfamily
I6H70_RS18760	COG3273	potassium ion transport
I6H70_RS18760	COG0471	metal ion transport
I6H70_RS18765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H70_RS18770	COG1301	dicarboxylic acid transport
I6H70_RS18775	COG1253	flavin adenine dinucleotide binding
I6H70_RS18790	COG3706	GGDEF domain
I6H70_RS18800	COG3530	Putative quorum-sensing-regulated virulence factor
I6H70_RS18810	COG2863	cytochrome
I6H70_RS18815	COG3258	Cytochrome c
I6H70_RS18825	COG2166	iron-sulfur cluster assembly
I6H70_RS18830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H70_RS18835	COG2171	N-acyltransferase activity
I6H70_RS18840	COG1393	Belongs to the ArsC family
I6H70_RS18860	COG0436	Aminotransferase
I6H70_RS18875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H70_RS18880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H70_RS18890	COG0628	permease
I6H70_RS18900	COG0456	acetyltransferase
I6H70_RS18920	COG1295	ribonuclease BN
I6H70_RS18950	COG0442	prolyl-tRNA aminoacylation
I6H70_RS18965	COG2900	Belongs to the SlyX family
I6H70_RS18970	COG1278	Cold shock
I6H70_RS18975	COG0783	Belongs to the Dps family
I6H70_RS18980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H70_RS18990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H70_RS18995	COG0632	four-way junction helicase activity
I6H70_RS19000	COG2255	four-way junction helicase activity
I6H70_RS19005	COG0824	Thioesterase
I6H70_RS19030	COG2885	chlorophyll binding
I6H70_RS19035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6H70_RS19040	COG0602	queuosine metabolic process
I6H70_RS19045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H70_RS19055	COG0427	acetyl-CoA hydrolase
I6H70_RS19065	COG4783	chaperone-mediated protein folding
I6H70_RS19070	COG0425	Belongs to the sulfur carrier protein TusA family
I6H70_RS19075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H70_RS19085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H70_RS19095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H70_RS19105	COG0582	viral genome integration into host DNA
I6H70_RS19115	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS19160	COG0789	Transcriptional regulator
I6H70_RS19175	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6H70_RS19180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H70_RS19195	COG2135	peptidase activity
I6H70_RS19295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H70_RS19310	COG2826	transposase and inactivated derivatives, IS30 family
I6H70_RS19335	COG1845	cytochrome c oxidase, subunit III
I6H70_RS19340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H70_RS19380	COG0437	4 iron, 4 sulfur cluster binding
I6H70_RS19390	COG3383	formate dehydrogenase (NAD+) activity
I6H70_RS19400	COG4991	sh3 domain protein
I6H70_RS19405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H70_RS19410	COG4208	sulfate ABC transporter
I6H70_RS19420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6H70_RS19425	COG5583	Uncharacterized small protein (DUF2292)
I6H70_RS19435	COG0450	alkyl hydroperoxide reductase
I6H70_RS19440	COG0417	DNA replication proofreading
I6H70_RS19490	COG3174	membrane
I6H70_RS19495	COG2205	protein histidine kinase activity
I6H70_RS19515	COG2814	Major facilitator Superfamily
I6H70_RS19520	COG2974	May be involved in recombination
I6H70_RS19535	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H70_RS19550	COG2948	multi-organism process
I6H70_RS19565	COG3846	protein secretion by the type IV secretion system
I6H70_RS19580	COG3451	type IV secretory pathway VirB4
I6H70_RS19590	COG3838	Conjugal transfer protein Trbc
I6H70_RS19595	COG4962	Type ii secretion system protein e
I6H70_RS19615	COG0583	DNA-binding transcription factor activity
I6H70_RS19640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H70_RS19660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H70_RS19670	COG4959	Type IV secretory pathway protease TraF
I6H70_RS19685	COG1192	Involved in chromosome partitioning
I6H70_RS19715	COG5489	Protein of unknown function (DUF736)
I6H70_RS19745	COG4372	Transposase
I6H70_RS19775	COG0640	Transcriptional regulator
I6H70_RS19800	COG0798	PFAM Bile acid sodium symporter
I6H70_RS19810	COG0431	NADPH-dependent FMN reductase
I6H70_RS19815	COG2003	Belongs to the UPF0758 family
I6H70_RS19820	COG4804	nuclease activity
I6H70_RS19825	COG1484	DNA-dependent DNA replication
I6H70_RS19830	COG4584	PFAM Integrase catalytic
I6H70_RS19870	COG0583	DNA-binding transcription factor activity
I6H70_RS19875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H70_RS19910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H70_RS19940	COG3267	Type II secretory pathway component ExeA
I6H70_RS19940	COG3409	Peptidoglycan-binding domain 1 protein
I6H70_RS19950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H70_RS19955	COG1459	type II secretion system
I6H70_RS19960	COG2165	general secretion pathway protein
I6H70_RS19970	COG4969	Belongs to the N-Me-Phe pilin family
I6H70_RS20030	COG0513	Belongs to the DEAD box helicase family
I6H70_RS20045	COG4935	Belongs to the peptidase S8 family
I6H70_RS20045	COG1404	Belongs to the peptidase S8 family
I6H70_RS20050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H70_RS20060	COG4221	oxidoreductase activity
I6H70_RS20070	COG1201	RNA secondary structure unwinding
I6H70_RS20105	COG2133	pyrroloquinoline quinone binding
I6H70_RS20110	COG4993	Dehydrogenase
I6H70_RS20115	COG2996	Protein conserved in bacteria
I6H70_RS20130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6H70_RS20160	COG1295	ribonuclease BN
I6H70_RS20180	COG3237	CsbD-like
I6H70_RS20185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6H70_RS20190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H70_RS20195	COG0582	viral genome integration into host DNA
I6H70_RS20210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H70_RS20210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H70_RS20235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H70_RS20240	COG1902	pentaerythritol trinitrate reductase activity
I6H70_RS20255	COG0583	DNA-binding transcription factor activity
I6H70_RS20260	COG4221	oxidoreductase activity
I6H70_RS20310	COG3321	synthase
I6H70_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
I6H70_RS20310	COG0604	alcohol dehydrogenase
I6H70_RS20330	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6H70_RS20335	COG1116	anion transmembrane transporter activity
I6H70_RS20340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H70_RS20345	COG1116	anion transmembrane transporter activity
I6H70_RS20345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H70_RS20350	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H70_RS20375	COG1546	Belongs to the CinA family
I6H70_RS20380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H70_RS20385	COG2137	regulation of response to DNA damage stimulus
I6H70_RS20395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6H70_RS20400	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6H70_RS20410	COG3148	PFAM DTW domain containing protein
I6H70_RS20415	COG0697	spore germination
I6H70_RS20425	COG0583	DNA-binding transcription factor activity
I6H70_RS20435	COG3012	SEC-C Motif Domain Protein
I6H70_RS20455	COG1199	ATP-dependent helicase activity
I6H70_RS20470	COG0259	pyridoxamine-phosphate oxidase activity
I6H70_RS20480	COG3133	Outer membrane lipoprotein
I6H70_RS20485	COG2111	Na H antiporter
I6H70_RS20485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H70_RS20490	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H70_RS20495	COG0651	ATP synthesis coupled electron transport
I6H70_RS20505	COG2212	antiporter activity
I6H70_RS20515	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6H70_RS20520	COG0024	Methionine aminopeptidase
I6H70_RS20525	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H70_RS20535	COG0528	UMP kinase activity
I6H70_RS20540	COG0233	cytoplasmic translational termination
I6H70_RS20545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H70_RS20555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H70_RS20565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H70_RS20580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H70_RS20585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H70_RS20590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H70_RS20595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H70_RS20610	COG0825	malonyl-CoA metabolic process
I6H70_RS20625	COG0504	CTP synthase activity
I6H70_RS20630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6H70_RS20645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H70_RS20660	COG0583	DNA-binding transcription factor activity
I6H70_RS20665	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6H70_RS20670	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H70_RS20680	COG1902	pentaerythritol trinitrate reductase activity
I6H70_RS20690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H70_RS20695	COG0585	pseudouridine synthase activity
I6H70_RS20700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6H70_RS20705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6H70_RS20730	COG0494	nUDIX hydrolase
I6H70_RS20735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H70_RS20745	COG0589	response to stress
I6H70_RS20755	COG0217	transcriptional regulatory protein
I6H70_RS20770	COG0004	ammonium transporteR
I6H70_RS20775	COG0483	inositol monophosphate 1-phosphatase activity
I6H70_RS20805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H70_RS20830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate