locus-tag	class	description
A0U95_RS00035	COG2010	Cytochrome c
A0U95_RS00050	COG0714	Associated with various cellular activities
A0U95_RS00055	COG1845	cytochrome c oxidase, subunit III
A0U95_RS00065	COG2010	Cytochrome c
A0U95_RS00070	COG3256	nitric oxide reductase
A0U95_RS00085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U95_RS00105	COG3604	Transcriptional regulator
A0U95_RS00110	COG0259	pyridoxamine-phosphate oxidase activity
A0U95_RS00115	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0U95_RS00125	COG0826	peptidase U32
A0U95_RS00130	COG0826	peptidase U32
A0U95_RS00135	COG3154	lipid carrier protein
A0U95_RS00145	COG3328	transposase activity
A0U95_RS00160	COG2197	response regulator
A0U95_RS00165	COG3850	Histidine kinase
A0U95_RS00175	COG2223	nitrite transmembrane transporter activity
A0U95_RS00180	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A0U95_RS00185	COG1140	nitrate reductase beta subunit
A0U95_RS00190	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A0U95_RS00195	COG2181	nitrate reductase activity
A0U95_RS00210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U95_RS00210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U95_RS00230	COG2814	Major facilitator Superfamily
A0U95_RS00245	COG1024	Enoyl-CoA hydratase
A0U95_RS00250	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS00255	COG1022	Amp-dependent synthetase and ligase
A0U95_RS00255	COG3320	Male sterility
A0U95_RS00295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A0U95_RS00305	COG2194	sulfuric ester hydrolase activity
A0U95_RS00310	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A0U95_RS00315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0U95_RS00320	COG0561	phosphatase activity
A0U95_RS00325	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0U95_RS00340	COG2204	response regulator
A0U95_RS00385	COG0840	transmembrane signaling receptor activity
A0U95_RS00390	COG1968	undecaprenyl-diphosphatase activity
A0U95_RS00410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A0U95_RS00425	COG0488	(ABC) transporter
A0U95_RS00440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A0U95_RS00450	COG2133	pyrroloquinoline quinone binding
A0U95_RS00455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0U95_RS00470	COG1070	Carbohydrate kinase
A0U95_RS00475	COG0246	Mannitol dehydrogenase
A0U95_RS00490	COG1175	transmembrane transport
A0U95_RS00515	COG5002	protein histidine kinase activity
A0U95_RS00515	COG0784	Response regulator, receiver
A0U95_RS00520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A0U95_RS00530	COG0784	Response regulator, receiver
A0U95_RS00530	COG2205	protein histidine kinase activity
A0U95_RS00545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0U95_RS00565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS00575	COG0583	DNA-binding transcription factor activity
A0U95_RS00600	COG4221	oxidoreductase activity
A0U95_RS00620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U95_RS00630	COG0604	alcohol dehydrogenase
A0U95_RS00645	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS00680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A0U95_RS00690	COG0589	response to stress
A0U95_RS00720	COG3958	Transketolase
A0U95_RS00725	COG3959	Transketolase, thiamine diphosphate binding domain
A0U95_RS00730	COG2271	Major facilitator Superfamily
A0U95_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS00740	COG0583	DNA-binding transcription factor activity
A0U95_RS00755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U95_RS00775	COG0460	homoserine dehydrogenase
A0U95_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS00785	COG0626	cystathionine gamma-synthase activity
A0U95_RS00820	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS00835	COG0583	DNA-binding transcription factor activity
A0U95_RS00855	COG1733	regulation of RNA biosynthetic process
A0U95_RS00880	COG1064	alcohol dehydrogenase
A0U95_RS00885	COG2207	Transcriptional regulator
A0U95_RS00895	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS00900	COG2197	response regulator
A0U95_RS00905	COG0477	Major facilitator Superfamily
A0U95_RS00915	COG0697	spore germination
A0U95_RS00920	COG4948	Mandelate Racemase Muconate Lactonizing
A0U95_RS00935	COG4638	Rieske (2fe-2S)
A0U95_RS00940	COG0583	DNA-binding transcription factor activity
A0U95_RS00945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U95_RS00950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS00960	COG3448	diguanylate cyclase activity
A0U95_RS00960	COG4175	Glycine betaine
A0U95_RS00965	COG4176	ABC-type proline glycine betaine transport system permease component
A0U95_RS00970	COG4176	ABC-type proline glycine betaine transport system permease component
A0U95_RS00975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U95_RS00980	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS00990	COG0840	transmembrane signaling receptor activity
A0U95_RS01000	COG4372	Transposase
A0U95_RS01015	COG1234	tRNA 3'-trailer cleavage
A0U95_RS01030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0U95_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS01050	COG0604	alcohol dehydrogenase
A0U95_RS01050	COG3321	synthase
A0U95_RS01060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS01075	COG0210	DNA helicase
A0U95_RS01080	COG1522	sequence-specific DNA binding
A0U95_RS01085	COG0697	spore germination
A0U95_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS01105	COG3568	Endonuclease Exonuclease Phosphatase
A0U95_RS01130	COG1640	4-alpha-glucanotransferase
A0U95_RS01135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0U95_RS01140	COG0297	glycogen (starch) synthase activity
A0U95_RS01145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U95_RS01150	COG2267	carboxylic ester hydrolase activity
A0U95_RS01155	COG1238	metal cluster binding
A0U95_RS01165	COG0840	transmembrane signaling receptor activity
A0U95_RS01205	COG2366	antibiotic biosynthetic process
A0U95_RS01240	COG0583	DNA-binding transcription factor activity
A0U95_RS01270	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A0U95_RS01280	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS01285	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS01295	COG4948	Mandelate Racemase Muconate Lactonizing
A0U95_RS01300	COG2271	Major facilitator Superfamily
A0U95_RS01315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0U95_RS01330	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0U95_RS01340	COG2146	nitrite reductase [NAD(P)H] activity
A0U95_RS01340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U95_RS01345	COG2146	nitrite reductase [NAD(P)H] activity
A0U95_RS01345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U95_RS01350	COG0517	IMP dehydrogenase activity
A0U95_RS01360	COG3447	MASE1 domain protein
A0U95_RS01360	COG5001	Diguanylate cyclase
A0U95_RS01360	COG5002	protein histidine kinase activity
A0U95_RS01370	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
A0U95_RS01400	COG2205	protein histidine kinase activity
A0U95_RS01400	COG0784	Response regulator, receiver
A0U95_RS01420	COG1595	DNA-templated transcription, initiation
A0U95_RS01455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0U95_RS01460	COG2207	Transcriptional regulator
A0U95_RS01470	COG0463	Glycosyl transferase, family 2
A0U95_RS01480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A0U95_RS01485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U95_RS01495	COG0183	Belongs to the thiolase family
A0U95_RS01500	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS01505	COG1024	Enoyl-CoA hydratase
A0U95_RS01510	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS01515	COG1024	Enoyl-CoA hydratase
A0U95_RS01545	COG0583	DNA-binding transcription factor activity
A0U95_RS01555	COG4336	lyase activity
A0U95_RS01565	COG2814	Major facilitator Superfamily
A0U95_RS01585	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS01600	COG1253	flavin adenine dinucleotide binding
A0U95_RS01625	COG1737	Transcriptional regulator
A0U95_RS01630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A0U95_RS01635	COG0747	negative chemotaxis
A0U95_RS01640	COG0601	transmembrane transport
A0U95_RS01645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0U95_RS01650	COG0444	Belongs to the ABC transporter superfamily
A0U95_RS01655	COG4608	Belongs to the ABC transporter superfamily
A0U95_RS01660	COG2072	flavoprotein involved in K transport
A0U95_RS01670	COG2144	transferase activity, transferring acyl groups
A0U95_RS01680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0U95_RS01695	COG3604	Transcriptional regulator
A0U95_RS01710	COG1522	sequence-specific DNA binding
A0U95_RS01720	COG2423	ornithine cyclodeaminase activity
A0U95_RS01725	COG1113	amino acid transport
A0U95_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS01810	COG0583	DNA-binding transcription factor activity
A0U95_RS01815	COG2814	Major facilitator Superfamily
A0U95_RS01825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0U95_RS01850	COG0436	Aminotransferase
A0U95_RS01865	COG1609	Transcriptional regulator
A0U95_RS01875	COG1175	transmembrane transport
A0U95_RS01880	COG1177	transmembrane transport
A0U95_RS01885	COG3842	ATPase activity
A0U95_RS01890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A0U95_RS01910	COG2207	Transcriptional regulator
A0U95_RS01925	COG0596	Alpha beta hydrolase
A0U95_RS01930	COG0596	Alpha beta hydrolase
A0U95_RS01960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A0U95_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS01975	COG1058	Belongs to the CinA family
A0U95_RS01975	COG1546	Belongs to the CinA family
A0U95_RS01990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A0U95_RS02025	COG1199	ATP-dependent helicase activity
A0U95_RS02025	COG1199	ATP-dependent helicase activity
A0U95_RS02040	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A0U95_RS02080	COG2814	Major facilitator Superfamily
A0U95_RS02110	COG0330	HflC and HflK could
A0U95_RS02180	COG2816	NAD+ diphosphatase activity
A0U95_RS02185	COG1024	Enoyl-CoA hydratase
A0U95_RS02190	COG1538	Outer membrane efflux protein
A0U95_RS02235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0U95_RS02265	COG0811	peptide transport
A0U95_RS02285	COG1305	Transglutaminase-like
A0U95_RS02295	COG2308	Evidence 4 Homologs of previously reported genes of
A0U95_RS02310	COG2267	carboxylic ester hydrolase activity
A0U95_RS02315	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS02325	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS02330	COG2186	Transcriptional regulator
A0U95_RS02345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0U95_RS02355	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0U95_RS02360	COG3833	ABC-type maltose transport systems, permease component
A0U95_RS02365	COG3842	ATPase activity
A0U95_RS02375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U95_RS02380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A0U95_RS02385	COG4774	siderophore transport
A0U95_RS02390	COG0840	transmembrane signaling receptor activity
A0U95_RS02395	COG2879	small protein
A0U95_RS02400	COG1966	Carbon starvation protein
A0U95_RS02435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A0U95_RS02440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A0U95_RS02445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A0U95_RS02450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A0U95_RS02460	COG1215	transferase activity, transferring glycosyl groups
A0U95_RS02480	COG1846	Transcriptional regulator
A0U95_RS02500	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS02505	COG3384	dioxygenase
A0U95_RS02515	COG2271	Major facilitator Superfamily
A0U95_RS02520	COG3971	2-oxopent-4-enoate hydratase activity
A0U95_RS02530	COG1846	Transcriptional regulator
A0U95_RS02535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0U95_RS02540	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS02545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS02585	COG0531	amino acid
A0U95_RS02600	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS02610	COG2814	Major facilitator Superfamily
A0U95_RS02630	COG4566	intracellular signal transduction
A0U95_RS02640	COG0583	DNA-binding transcription factor activity
A0U95_RS02665	COG2072	flavoprotein involved in K transport
A0U95_RS02675	COG1741	Belongs to the pirin family
A0U95_RS02680	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS02690	COG4221	oxidoreductase activity
A0U95_RS02705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0U95_RS02730	COG1609	Transcriptional regulator
A0U95_RS02740	COG0673	inositol 2-dehydrogenase activity
A0U95_RS02745	COG1082	Xylose isomerase domain protein TIM barrel
A0U95_RS02755	COG5001	Diguanylate cyclase
A0U95_RS02755	COG3706	GGDEF domain
A0U95_RS02755	COG4251	negative regulation of phosphorylation
A0U95_RS02755	COG2203	Gaf domain
A0U95_RS02760	COG0826	peptidase U32
A0U95_RS02855	COG0583	DNA-binding transcription factor activity
A0U95_RS02870	COG2851	Citrate transporter
A0U95_RS02875	COG0579	oxidoreductase
A0U95_RS02880	COG2205	protein histidine kinase activity
A0U95_RS02950	COG1131	(ABC) transporter
A0U95_RS02970	COG2205	protein histidine kinase activity
A0U95_RS02970	COG0784	Response regulator, receiver
A0U95_RS02985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A0U95_RS03045	COG1538	Outer membrane efflux protein
A0U95_RS03065	COG1309	transcriptional regulator
A0U95_RS03085	COG4566	intracellular signal transduction
A0U95_RS03120	COG3829	transcription factor binding
A0U95_RS03155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U95_RS03165	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS03190	COG2384	SAM-dependent methyltransferase
A0U95_RS03200	COG1349	DNA-binding transcription factor activity
A0U95_RS03205	COG0667	Aldo Keto reductase
A0U95_RS03210	COG0583	DNA-binding transcription factor activity
A0U95_RS03230	COG3011	Protein conserved in bacteria
A0U95_RS03245	COG1609	Transcriptional regulator
A0U95_RS03245	COG2207	Transcriptional regulator
A0U95_RS03250	COG2115	Belongs to the xylose isomerase family
A0U95_RS03255	COG4213	ABC transporter substrate-binding protein
A0U95_RS03260	COG1129	ABC transporter
A0U95_RS03265	COG4214	carbohydrate transport
A0U95_RS03270	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS03275	COG0583	DNA-binding transcription factor activity
A0U95_RS03285	COG0596	Alpha beta hydrolase
A0U95_RS03320	COG3383	formate dehydrogenase (NAD+) activity
A0U95_RS03365	COG3038	cytochrome b561
A0U95_RS03380	COG0431	NADPH-dependent FMN reductase
A0U95_RS03415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A0U95_RS03420	COG1335	isochorismatase
A0U95_RS03425	COG0583	DNA-binding transcription factor activity
A0U95_RS03440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A0U95_RS03445	COG2197	response regulator
A0U95_RS03450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0U95_RS03475	COG0640	Transcriptional regulator
A0U95_RS03480	COG1132	(ABC) transporter
A0U95_RS03510	COG0537	adenosine 5'-monophosphoramidase activity
A0U95_RS03520	COG3920	Histidine kinase
A0U95_RS03520	COG2202	Pas domain
A0U95_RS03530	COG2814	Major facilitator Superfamily
A0U95_RS03565	COG1477	protein flavinylation
A0U95_RS03570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A0U95_RS03575	COG4977	sequence-specific DNA binding
A0U95_RS03575	COG1917	Cupin 2, conserved barrel domain protein
A0U95_RS03585	COG0583	DNA-binding transcription factor activity
A0U95_RS03600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0U95_RS03605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U95_RS03615	COG0071	Belongs to the small heat shock protein (HSP20) family
A0U95_RS03620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A0U95_RS03625	COG0589	response to stress
A0U95_RS03630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A0U95_RS03650	COG0589	response to stress
A0U95_RS03685	COG1294	oxidase, subunit
A0U95_RS03710	COG0730	response to heat
A0U95_RS03730	COG2072	flavoprotein involved in K transport
A0U95_RS03735	COG0642	Histidine kinase
A0U95_RS03750	COG4221	oxidoreductase activity
A0U95_RS03760	COG1022	Amp-dependent synthetase and ligase
A0U95_RS03770	COG0154	amidase activity
A0U95_RS03775	COG0583	DNA-binding transcription factor activity
A0U95_RS03795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS03800	COG4977	sequence-specific DNA binding
A0U95_RS03800	COG1917	Cupin 2, conserved barrel domain protein
A0U95_RS03810	COG0583	DNA-binding transcription factor activity
A0U95_RS03815	COG0625	glutathione transferase activity
A0U95_RS03820	COG1017	nitric oxide dioxygenase activity
A0U95_RS03820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0U95_RS03850	COG0583	DNA-binding transcription factor activity
A0U95_RS03860	COG2207	Transcriptional regulator
A0U95_RS03870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0U95_RS03875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0U95_RS03885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A0U95_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS03955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0U95_RS03960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0U95_RS03970	COG2188	Transcriptional regulator
A0U95_RS04000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS04025	COG2197	response regulator
A0U95_RS04045	COG0019	diaminopimelate decarboxylase activity
A0U95_RS04050	COG0248	Ppx GppA phosphatase
A0U95_RS04060	COG0306	phosphate transporter
A0U95_RS04065	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A0U95_RS04070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A0U95_RS04075	COG3639	organic phosphonate transmembrane transporter activity
A0U95_RS04080	COG3639	organic phosphonate transmembrane transporter activity
A0U95_RS04090	COG0667	Aldo Keto reductase
A0U95_RS04100	COG5001	Diguanylate cyclase
A0U95_RS04100	COG4251	negative regulation of phosphorylation
A0U95_RS04100	COG2203	Gaf domain
A0U95_RS04100	COG3706	GGDEF domain
A0U95_RS04110	COG0625	glutathione transferase activity
A0U95_RS04125	COG1191	sigma factor activity
A0U95_RS04155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A0U95_RS04185	COG1766	The M ring may be actively involved in energy transduction
A0U95_RS04190	COG1677	Flagellar hook-basal body complex protein FliE
A0U95_RS04205	COG1706	bacterial-type flagellum-dependent cell motility
A0U95_RS04220	COG4786	Flagellar basal body rod
A0U95_RS04225	COG4786	Flagellar basal body rod
A0U95_RS04230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U95_RS04235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U95_RS04245	COG1987	bacterial-type flagellum assembly
A0U95_RS04285	COG0840	transmembrane signaling receptor activity
A0U95_RS04295	COG4774	siderophore transport
A0U95_RS04295	COG1629	transport
A0U95_RS04330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0U95_RS04345	COG4178	(ABC) transporter
A0U95_RS04370	COG2197	response regulator
A0U95_RS04385	COG1063	alcohol dehydrogenase
A0U95_RS04390	COG2721	sulfolactate sulfo-lyase activity
A0U95_RS04395	COG2186	Transcriptional regulator
A0U95_RS04400	COG1312	Catalyzes the dehydration of D-mannonate
A0U95_RS04405	COG0246	Mannitol dehydrogenase
A0U95_RS04410	COG2271	Major facilitator Superfamily
A0U95_RS04415	COG1063	alcohol dehydrogenase
A0U95_RS04420	COG4948	Mandelate Racemase Muconate Lactonizing
A0U95_RS04440	COG1653	transport
A0U95_RS04455	COG3842	ATPase activity
A0U95_RS04460	COG1621	beta-fructofuranosidase activity
A0U95_RS04470	COG1309	transcriptional regulator
A0U95_RS04475	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS04480	COG0300	oxidoreductase activity
A0U95_RS04485	COG0604	alcohol dehydrogenase
A0U95_RS04505	COG0765	amino acid transport
A0U95_RS04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS04515	COG1802	Transcriptional regulator
A0U95_RS04520	COG2207	Transcriptional regulator
A0U95_RS04525	COG3971	2-oxopent-4-enoate hydratase activity
A0U95_RS04530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS04560	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS04565	COG0028	Belongs to the TPP enzyme family
A0U95_RS04580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0U95_RS04595	COG0840	transmembrane signaling receptor activity
A0U95_RS04600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS04615	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS04620	COG2271	Major facilitator Superfamily
A0U95_RS04635	COG0129	dihydroxy-acid dehydratase activity
A0U95_RS04655	COG1309	transcriptional regulator
A0U95_RS04775	COG2851	Citrate transporter
A0U95_RS04780	COG1301	dicarboxylic acid transport
A0U95_RS04785	COG2828	Protein conserved in bacteria
A0U95_RS04790	COG0583	DNA-binding transcription factor activity
A0U95_RS04795	COG2814	Major facilitator Superfamily
A0U95_RS04820	COG5645	(Lipo)protein
A0U95_RS04840	COG3829	transcription factor binding
A0U95_RS04845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U95_RS04905	COG2814	Major facilitator Superfamily
A0U95_RS04915	COG1073	alpha beta
A0U95_RS04950	COG0512	Glutamine amidotransferase of anthranilate synthase
A0U95_RS04965	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U95_RS04970	COG1309	transcriptional regulator
A0U95_RS04975	COG4566	intracellular signal transduction
A0U95_RS04980	COG4191	Histidine kinase
A0U95_RS04985	COG0318	PFAM AMP-dependent synthetase and ligase
A0U95_RS04990	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS05020	COG3795	YCII-related domain
A0U95_RS05025	COG0484	heat shock protein binding
A0U95_RS05030	COG0443	Heat shock 70 kDa protein
A0U95_RS05040	COG3437	response regulator, receiver
A0U95_RS05045	COG2202	Pas domain
A0U95_RS05045	COG2205	protein histidine kinase activity
A0U95_RS05055	COG2197	response regulator
A0U95_RS05060	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A0U95_RS05070	COG0835	chemotaxis
A0U95_RS05075	COG0835	chemotaxis
A0U95_RS05080	COG0840	transmembrane signaling receptor activity
A0U95_RS05085	COG2198	Histidine kinase
A0U95_RS05085	COG0643	Histidine kinase
A0U95_RS05095	COG0745	RESPONSE REGULATOR receiver
A0U95_RS05115	COG0189	ligase activity
A0U95_RS05120	COG0598	Magnesium transport protein CorA
A0U95_RS05135	COG0673	inositol 2-dehydrogenase activity
A0U95_RS05155	COG2197	response regulator
A0U95_RS05160	COG3850	Histidine kinase
A0U95_RS05170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0U95_RS05180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0U95_RS05195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0U95_RS05205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0U95_RS05210	COG0004	ammonium transporteR
A0U95_RS05215	COG0069	glutamate synthase activity
A0U95_RS05220	COG2218	PFAM glutamate synthase alpha subunit domain protein
A0U95_RS05225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0U95_RS05245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0U95_RS05260	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0U95_RS05260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0U95_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS05280	COG0583	DNA-binding transcription factor activity
A0U95_RS05290	COG2814	Major facilitator Superfamily
A0U95_RS05315	COG0601	transmembrane transport
A0U95_RS05325	COG0444	Belongs to the ABC transporter superfamily
A0U95_RS05330	COG4608	Belongs to the ABC transporter superfamily
A0U95_RS05365	COG1522	sequence-specific DNA binding
A0U95_RS05380	COG0583	DNA-binding transcription factor activity
A0U95_RS05390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A0U95_RS05400	COG0523	cobalamin synthesis protein
A0U95_RS05410	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS05430	COG0154	amidase activity
A0U95_RS05435	COG1802	Transcriptional regulator
A0U95_RS05440	COG0840	transmembrane signaling receptor activity
A0U95_RS05450	COG2200	EAL domain
A0U95_RS05455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U95_RS05460	COG1566	PFAM secretion protein HlyD family protein
A0U95_RS05480	COG0583	DNA-binding transcription factor activity
A0U95_RS05500	COG2207	Transcriptional regulator
A0U95_RS05530	COG0583	DNA-binding transcription factor activity
A0U95_RS05535	COG1045	serine acetyltransferase
A0U95_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS05555	COG1473	amidohydrolase
A0U95_RS05560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS05575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS05600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A0U95_RS05605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U95_RS05660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS05680	COG0840	transmembrane signaling receptor activity
A0U95_RS05700	COG0322	excinuclease ABC activity
A0U95_RS05705	COG2197	response regulator
A0U95_RS05720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A0U95_RS05730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A0U95_RS05735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0U95_RS05740	COG4166	transmembrane transport
A0U95_RS05745	COG4174	ABC transporter (Permease)
A0U95_RS05750	COG4239	(ABC) transporter, permease
A0U95_RS05755	COG4172	Belongs to the ABC transporter superfamily
A0U95_RS05775	COG2610	gluconate transmembrane transporter activity
A0U95_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS05785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U95_RS05800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0U95_RS05805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U95_RS05825	COG1126	abc transporter atp-binding protein
A0U95_RS05830	COG0765	amino acid transport
A0U95_RS05835	COG0765	amino acid transport
A0U95_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS05900	COG0316	Belongs to the HesB IscA family
A0U95_RS05900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A0U95_RS05920	COG1879	ABC-type sugar transport system periplasmic component
A0U95_RS05935	COG0616	signal peptide processing
A0U95_RS05950	COG1024	Enoyl-CoA hydratase
A0U95_RS05950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A0U95_RS05975	COG0784	Response regulator, receiver
A0U95_RS05975	COG4191	Histidine kinase
A0U95_RS05980	COG0587	DNA-directed DNA polymerase activity
A0U95_RS05995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0U95_RS06015	COG3245	cytochrome
A0U95_RS06040	COG3712	iron ion homeostasis
A0U95_RS06045	COG1595	DNA-templated transcription, initiation
A0U95_RS06050	COG2204	response regulator
A0U95_RS06055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0U95_RS06065	COG2066	Belongs to the glutaminase family
A0U95_RS06105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A0U95_RS06110	COG0583	DNA-binding transcription factor activity
A0U95_RS06115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A0U95_RS06130	COG2186	Transcriptional regulator
A0U95_RS06145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0U95_RS06160	COG1285	pathogenesis
A0U95_RS06170	COG0348	domain, Protein
A0U95_RS06175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS06200	COG0730	response to heat
A0U95_RS06215	COG0656	L-ascorbic acid biosynthetic process
A0U95_RS06220	COG0417	DNA replication proofreading
A0U95_RS06225	COG0517	IMP dehydrogenase activity
A0U95_RS06235	COG2995	paraquat-inducible protein a
A0U95_RS06240	COG3008	intermembrane lipid transfer
A0U95_RS06265	COG0113	porphobilinogen synthase activity
A0U95_RS06270	COG0625	glutathione transferase activity
A0U95_RS06280	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A0U95_RS06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS06330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0U95_RS06335	COG4977	sequence-specific DNA binding
A0U95_RS06355	COG1335	isochorismatase
A0U95_RS06370	COG0531	amino acid
A0U95_RS06400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A0U95_RS06405	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS06415	COG0789	Transcriptional regulator
A0U95_RS06425	COG0318	PFAM AMP-dependent synthetase and ligase
A0U95_RS06430	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS06435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A0U95_RS06440	COG1024	Enoyl-CoA hydratase
A0U95_RS06460	COG2866	Carboxypeptidase
A0U95_RS06465	COG3038	cytochrome b561
A0U95_RS06470	COG0753	catalase activity
A0U95_RS06485	COG1414	Transcriptional regulator
A0U95_RS06490	COG3842	ATPase activity
A0U95_RS06495	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0U95_RS06500	COG1177	transmembrane transport
A0U95_RS06530	COG0217	transcriptional regulatory protein
A0U95_RS06540	COG3038	cytochrome b561
A0U95_RS06550	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS06550	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0U95_RS06575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0U95_RS06580	COG0776	regulation of translation
A0U95_RS06585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0U95_RS06590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A0U95_RS06595	COG0740	serine-type endopeptidase activity
A0U95_RS06600	COG0544	peptidyl-prolyl cis-trans isomerase activity
A0U95_RS06620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0U95_RS06625	COG1686	Belongs to the peptidase S11 family
A0U95_RS06640	COG1253	flavin adenine dinucleotide binding
A0U95_RS06650	COG0583	DNA-binding transcription factor activity
A0U95_RS06655	COG2814	Major facilitator Superfamily
A0U95_RS06660	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A0U95_RS06670	COG3132	Protein of unknown function, DUF480
A0U95_RS06675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0U95_RS06685	COG2233	PERMEase
A0U95_RS06695	COG0708	Exodeoxyribonuclease III
A0U95_RS06700	COG3300	MHYT domain
A0U95_RS06700	COG5001	Diguanylate cyclase
A0U95_RS06705	COG3706	GGDEF domain
A0U95_RS06705	COG2203	Gaf domain
A0U95_RS06705	COG4251	negative regulation of phosphorylation
A0U95_RS06705	COG5001	Diguanylate cyclase
A0U95_RS06730	COG1733	regulation of RNA biosynthetic process
A0U95_RS06745	COG1064	alcohol dehydrogenase
A0U95_RS06750	COG2207	Transcriptional regulator
A0U95_RS06760	COG1301	dicarboxylic acid transport
A0U95_RS06765	COG0583	DNA-binding transcription factor activity
A0U95_RS06785	COG2184	nucleotidyltransferase activity
A0U95_RS06820	COG2135	peptidase activity
A0U95_RS06840	COG3179	chitinase
A0U95_RS06995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0U95_RS07040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A0U95_RS07045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0U95_RS07055	COG2204	response regulator
A0U95_RS07060	COG2853	Lipoprotein
A0U95_RS07075	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A0U95_RS07075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A0U95_RS07095	COG4591	ABC-type transport system involved in lipoprotein release permease component
A0U95_RS07100	COG1136	(ABC) transporter
A0U95_RS07105	COG4591	ABC-type transport system involved in lipoprotein release permease component
A0U95_RS07115	COG0584	glycerophosphoryl diester phosphodiesterase
A0U95_RS07120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U95_RS07125	COG1477	protein flavinylation
A0U95_RS07140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A0U95_RS07150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0U95_RS07155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0U95_RS07200	COG0183	Belongs to the thiolase family
A0U95_RS07205	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U95_RS07205	COG1024	Enoyl-CoA hydratase
A0U95_RS07215	COG0589	response to stress
A0U95_RS07220	COG0488	(ABC) transporter
A0U95_RS07225	COG0741	lytic transglycosylase activity
A0U95_RS07230	COG1132	(ABC) transporter
A0U95_RS07240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U95_RS07250	COG0425	Belongs to the sulfur carrier protein TusA family
A0U95_RS07255	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A0U95_RS07270	COG0840	transmembrane signaling receptor activity
A0U95_RS07280	COG3278	Belongs to the heme-copper respiratory oxidase family
A0U95_RS07300	COG3278	Belongs to the heme-copper respiratory oxidase family
A0U95_RS07315	COG2010	Cytochrome c
A0U95_RS07320	COG0348	domain, Protein
A0U95_RS07350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U95_RS07355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0U95_RS07360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0U95_RS07365	COG2130	NADP-dependent
A0U95_RS07370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A0U95_RS07375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A0U95_RS07415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0U95_RS07420	COG3115	cell septum assembly
A0U95_RS07450	COG0402	S-adenosylhomocysteine deaminase activity
A0U95_RS07455	COG1802	Transcriptional regulator
A0U95_RS07460	COG3135	benzoate transporter
A0U95_RS07465	COG3171	Protein conserved in bacteria
A0U95_RS07470	COG2027	D-alanyl-D-alanine carboxypeptidase
A0U95_RS07480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0U95_RS07480	COG0116	Belongs to the methyltransferase superfamily
A0U95_RS07485	COG0167	dihydroorotate dehydrogenase activity
A0U95_RS07490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0U95_RS07490	COG1116	anion transmembrane transporter activity
A0U95_RS07495	COG3707	response regulator
A0U95_RS07500	COG2223	nitrite transmembrane transporter activity
A0U95_RS07510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U95_RS07515	COG2146	nitrite reductase [NAD(P)H] activity
A0U95_RS07520	COG0243	molybdopterin cofactor binding
A0U95_RS07525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A0U95_RS07540	COG0668	transmembrane transport
A0U95_RS07555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A0U95_RS07575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A0U95_RS07590	COG0642	Histidine kinase
A0U95_RS07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0U95_RS07650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A0U95_RS07655	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS07670	COG3123	guanosine phosphorylase activity
A0U95_RS07675	COG0633	Ferredoxin
A0U95_RS07675	COG3217	Mosc domain protein beta barrel domain protein
A0U95_RS07700	COG1597	lipid kinase activity
A0U95_RS07710	COG0303	'Molybdopterin
A0U95_RS07715	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0U95_RS07720	COG0746	molybdenum cofactor guanylyltransferase activity
A0U95_RS07730	COG0564	pseudouridine synthase activity
A0U95_RS07750	COG0004	ammonium transporteR
A0U95_RS07775	COG2197	response regulator
A0U95_RS07780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS07780	COG2205	protein histidine kinase activity
A0U95_RS07785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A0U95_RS07785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A0U95_RS07790	COG1956	GAF domain-containing protein
A0U95_RS07800	COG2205	protein histidine kinase activity
A0U95_RS07800	COG5002	protein histidine kinase activity
A0U95_RS07800	COG0784	Response regulator, receiver
A0U95_RS07805	COG1846	Transcriptional regulator
A0U95_RS07810	COG0386	Belongs to the glutathione peroxidase family
A0U95_RS07815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0U95_RS07820	COG0436	Aminotransferase
A0U95_RS07825	COG0501	Belongs to the peptidase M48B family
A0U95_RS07830	COG0500	methyltransferase
A0U95_RS07835	COG3384	dioxygenase
A0U95_RS07850	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A0U95_RS07855	COG3214	Protein conserved in bacteria
A0U95_RS07865	COG0583	DNA-binding transcription factor activity
A0U95_RS07875	COG1846	Transcriptional regulator
A0U95_RS07880	COG1764	response to oxidative stress
A0U95_RS07890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0U95_RS07905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0U95_RS07925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A0U95_RS07945	COG1376	ErfK ybiS ycfS ynhG family protein
A0U95_RS07960	COG4181	ATPase activity
A0U95_RS07965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A0U95_RS07980	COG2259	Doxx family
A0U95_RS07985	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A0U95_RS07990	COG0084	hydrolase, TatD family'
A0U95_RS08025	COG0745	RESPONSE REGULATOR receiver
A0U95_RS08030	COG2205	protein histidine kinase activity
A0U95_RS08035	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A0U95_RS08045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A0U95_RS08085	COG4106	trans-aconitate 2-methyltransferase activity
A0U95_RS08100	COG2076	Multidrug Resistance protein
A0U95_RS08105	COG1555	photosystem II stabilization
A0U95_RS08120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A0U95_RS08135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0U95_RS08160	COG1086	Polysaccharide biosynthesis protein
A0U95_RS08170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0U95_RS08175	COG0519	Catalyzes the synthesis of GMP from XMP
A0U95_RS08180	COG1215	transferase activity, transferring glycosyl groups
A0U95_RS08225	COG0776	regulation of translation
A0U95_RS08240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A0U95_RS08245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A0U95_RS08250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U95_RS08260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A0U95_RS08270	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0U95_RS08275	COG0402	S-adenosylhomocysteine deaminase activity
A0U95_RS08280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0U95_RS08285	COG0546	phosphoglycolate phosphatase activity
A0U95_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS08305	COG5002	protein histidine kinase activity
A0U95_RS08305	COG5001	Diguanylate cyclase
A0U95_RS08320	COG1054	Belongs to the UPF0176 family
A0U95_RS08325	COG0271	Belongs to the BolA IbaG family
A0U95_RS08335	COG0114	fumarate hydratase activity
A0U95_RS08340	COG0697	spore germination
A0U95_RS08350	COG0183	Belongs to the thiolase family
A0U95_RS08355	COG2326	polyphosphate kinase activity
A0U95_RS08360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A0U95_RS08360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS08365	COG0367	asparagine synthase
A0U95_RS08370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0U95_RS08370	COG0189	ligase activity
A0U95_RS08375	COG1363	Peptidase, m42
A0U95_RS08380	COG3089	Belongs to the UPF0270 family
A0U95_RS08385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A0U95_RS08390	COG1742	UPF0060 membrane protein
A0U95_RS08405	COG1368	sulfuric ester hydrolase activity
A0U95_RS08420	COG3088	subunit of a heme lyase
A0U95_RS08430	COG1138	Cytochrome C-type biogenesis protein
A0U95_RS08435	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A0U95_RS08455	COG4133	protoheme IX ABC transporter activity
A0U95_RS08465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U95_RS08475	COG0835	chemotaxis
A0U95_RS08485	COG1192	Involved in chromosome partitioning
A0U95_RS08495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A0U95_RS08500	COG2201	protein-glutamate methylesterase activity
A0U95_RS08505	COG2198	Histidine kinase
A0U95_RS08505	COG0784	Response regulator, receiver
A0U95_RS08505	COG0643	Histidine kinase
A0U95_RS08510	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A0U95_RS08535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U95_RS08590	COG0745	RESPONSE REGULATOR receiver
A0U95_RS08625	COG1677	Flagellar hook-basal body complex protein FliE
A0U95_RS08655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A0U95_RS08665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0U95_RS08675	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS08675	COG1216	Glycosyl transferase, family 2
A0U95_RS08690	COG1256	bacterial-type flagellum assembly
A0U95_RS08700	COG1706	bacterial-type flagellum-dependent cell motility
A0U95_RS08705	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A0U95_RS08715	COG4786	Flagellar basal body rod
A0U95_RS08720	COG1216	Glycosyl transferase, family 2
A0U95_RS08720	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS08765	COG2154	pterin-4-alpha-carbinolamine dehydratase
A0U95_RS08780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0U95_RS08820	COG1752	Esterase of the alpha-beta hydrolase superfamily
A0U95_RS08835	COG0514	ATP-dependent DNA helicase (RecQ)
A0U95_RS08845	COG2832	Protein of unknown function (DUF454)
A0U95_RS08865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS08895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0U95_RS08900	COG0583	DNA-binding transcription factor activity
A0U95_RS08910	COG1953	Uracil, thiamine, allantoin
A0U95_RS08915	COG2996	Protein conserved in bacteria
A0U95_RS08945	COG3093	addiction module antidote protein HigA
A0U95_RS08955	COG0513	Belongs to the DEAD box helicase family
A0U95_RS08960	COG0668	transmembrane transport
A0U95_RS08970	COG2198	Histidine kinase
A0U95_RS08970	COG2205	protein histidine kinase activity
A0U95_RS08970	COG0784	Response regulator, receiver
A0U95_RS08975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A0U95_RS08990	COG2267	carboxylic ester hydrolase activity
A0U95_RS09000	COG1132	(ABC) transporter
A0U95_RS09025	COG1595	DNA-templated transcription, initiation
A0U95_RS09035	COG1643	Atp-dependent helicase
A0U95_RS09040	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A0U95_RS09060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A0U95_RS09075	COG0542	response to heat
A0U95_RS09085	COG1984	allophanate hydrolase subunit 2
A0U95_RS09090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A0U95_RS09095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A0U95_RS09100	COG2814	Major facilitator Superfamily
A0U95_RS09110	COG0121	glutamine amidotransferase
A0U95_RS09180	COG2983	Belongs to the UPF0260 family
A0U95_RS09195	COG3100	YcgL domain-containing protein
A0U95_RS09210	COG2194	sulfuric ester hydrolase activity
A0U95_RS09215	COG0174	glutamine synthetase
A0U95_RS09250	COG0463	Glycosyl transferase, family 2
A0U95_RS09265	COG0662	Cupin 2, conserved barrel domain protein
A0U95_RS09290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0U95_RS09295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0U95_RS09300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A0U95_RS09305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U95_RS09315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0U95_RS09325	COG0425	Belongs to the sulfur carrier protein TusA family
A0U95_RS09330	COG4783	chaperone-mediated protein folding
A0U95_RS09335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0U95_RS09365	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A0U95_RS09380	COG0642	Histidine kinase
A0U95_RS09405	COG3180	Ammonia monooxygenase
A0U95_RS09415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A0U95_RS09440	COG3842	ATPase activity
A0U95_RS09450	COG3665	Urea carboxylase-associated protein
A0U95_RS09455	COG0439	Biotin carboxylase
A0U95_RS09480	COG2267	carboxylic ester hydrolase activity
A0U95_RS09505	COG1522	sequence-specific DNA binding
A0U95_RS09555	COG1454	alcohol dehydrogenase
A0U95_RS09565	COG3422	double-strand break repair
A0U95_RS09570	COG0693	protein deglycase activity
A0U95_RS09585	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A0U95_RS09590	COG1704	LemA family
A0U95_RS09600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0U95_RS09645	COG2814	Major facilitator Superfamily
A0U95_RS09650	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS09660	COG1309	transcriptional regulator
A0U95_RS09665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS09695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS09700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U95_RS09710	COG0477	Major facilitator Superfamily
A0U95_RS09715	COG3485	protocatechuate 3,4-dioxygenase
A0U95_RS09720	COG3485	protocatechuate 3,4-dioxygenase
A0U95_RS09725	COG0183	Belongs to the thiolase family
A0U95_RS09730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A0U95_RS09735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A0U95_RS09740	COG2814	Major facilitator Superfamily
A0U95_RS09745	COG1414	Transcriptional regulator
A0U95_RS09755	COG0306	phosphate transporter
A0U95_RS09765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0U95_RS09770	COG3328	transposase activity
A0U95_RS09785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U95_RS09790	COG0583	DNA-binding transcription factor activity
A0U95_RS09800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A0U95_RS09815	COG4941	Belongs to the sigma-70 factor family
A0U95_RS09825	COG3795	YCII-related domain
A0U95_RS09855	COG0436	Aminotransferase
A0U95_RS09865	COG3265	gluconokinase activity
A0U95_RS09870	COG1609	Transcriptional regulator
A0U95_RS09885	COG0242	peptide deformylase activity
A0U95_RS09890	COG1295	ribonuclease BN
A0U95_RS09900	COG0318	PFAM AMP-dependent synthetase and ligase
A0U95_RS09905	COG0318	PFAM AMP-dependent synthetase and ligase
A0U95_RS09910	COG2267	carboxylic ester hydrolase activity
A0U95_RS09915	COG2030	dehydratase
A0U95_RS09940	COG3530	Putative quorum-sensing-regulated virulence factor
A0U95_RS09950	COG0800	Aldolase
A0U95_RS09965	COG1737	Transcriptional regulator
A0U95_RS09970	COG0676	glucose-6-phosphate 1-epimerase activity
A0U95_RS09980	COG3842	ATPase activity
A0U95_RS09985	COG0395	ABC-type sugar transport system, permease component
A0U95_RS09990	COG1175	transmembrane transport
A0U95_RS09995	COG1653	transport
A0U95_RS10030	COG1595	DNA-templated transcription, initiation
A0U95_RS10035	COG3712	iron ion homeostasis
A0U95_RS10040	COG4771	TonB-dependent receptor
A0U95_RS10050	COG2832	Protein of unknown function (DUF454)
A0U95_RS10055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A0U95_RS10105	COG2271	Major facilitator Superfamily
A0U95_RS10150	COG3220	belongs to the UPF0276 family
A0U95_RS10165	COG0583	DNA-binding transcription factor activity
A0U95_RS10180	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A0U95_RS10190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0U95_RS10205	COG0259	pyridoxamine-phosphate oxidase activity
A0U95_RS10210	COG2885	chlorophyll binding
A0U95_RS10215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0U95_RS10220	COG1199	ATP-dependent helicase activity
A0U95_RS10255	COG3012	SEC-C Motif Domain Protein
A0U95_RS10265	COG0653	protein targeting
A0U95_RS10275	COG2366	antibiotic biosynthetic process
A0U95_RS10285	COG1793	dna ligase
A0U95_RS10315	COG1201	RNA secondary structure unwinding
A0U95_RS10330	COG0717	Belongs to the dCTP deaminase family
A0U95_RS10335	COG1278	Cold shock
A0U95_RS10355	COG0442	prolyl-tRNA aminoacylation
A0U95_RS10365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0U95_RS10380	COG0392	lysyltransferase activity
A0U95_RS10380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A0U95_RS10390	COG3158	transport of potassium into the cell
A0U95_RS10395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U95_RS10405	COG1187	pseudouridine synthase activity
A0U95_RS10410	COG4807	Protein conserved in bacteria
A0U95_RS10425	COG0583	DNA-binding transcription factor activity
A0U95_RS10440	COG3148	PFAM DTW domain containing protein
A0U95_RS10460	COG2137	regulation of response to DNA damage stimulus
A0U95_RS10465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A0U95_RS10470	COG1546	Belongs to the CinA family
A0U95_RS10480	COG3179	chitinase
A0U95_RS10525	COG4381	Mu-like prophage protein gp46
A0U95_RS10560	COG4386	tail sheath protein
A0U95_RS10605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0U95_RS10610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A0U95_RS10625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A0U95_RS10630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A0U95_RS10635	COG0585	pseudouridine synthase activity
A0U95_RS10640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A0U95_RS10645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A0U95_RS10650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A0U95_RS10660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A0U95_RS10670	COG0148	phosphopyruvate hydratase activity
A0U95_RS10675	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A0U95_RS10680	COG0504	CTP synthase activity
A0U95_RS10685	COG0037	tRNA processing
A0U95_RS10690	COG0825	malonyl-CoA metabolic process
A0U95_RS10695	COG0587	DNA-directed DNA polymerase activity
A0U95_RS10700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0U95_RS10705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U95_RS10710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U95_RS10715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0U95_RS10720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U95_RS10730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U95_RS10740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A0U95_RS10750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0U95_RS10755	COG0233	cytoplasmic translational termination
A0U95_RS10760	COG0528	UMP kinase activity
A0U95_RS10765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A0U95_RS10770	COG0052	Belongs to the universal ribosomal protein uS2 family
A0U95_RS10775	COG0024	Methionine aminopeptidase
A0U95_RS10780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A0U95_RS10785	COG0436	Aminotransferase
A0U95_RS10790	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
A0U95_RS10805	COG0025	NhaP-type Na H and K H
A0U95_RS10815	COG1393	Belongs to the ArsC family
A0U95_RS10820	COG2171	N-acyltransferase activity
A0U95_RS10825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0U95_RS10835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A0U95_RS10840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0U95_RS10845	COG2226	methyltransferase
A0U95_RS10860	COG2937	Belongs to the GPAT DAPAT family
A0U95_RS10870	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A0U95_RS10895	COG0742	ribosomal rna small subunit methyltransferase
A0U95_RS10915	COG1801	Protein of unknown function DUF72
A0U95_RS10930	COG0563	adenylate kinase activity
A0U95_RS10935	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A0U95_RS10950	COG2885	chlorophyll binding
A0U95_RS10980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A0U95_RS10985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A0U95_RS10990	COG2203	Gaf domain
A0U95_RS10990	COG3706	GGDEF domain
A0U95_RS10990	COG4251	negative regulation of phosphorylation
A0U95_RS10990	COG5001	Diguanylate cyclase
A0U95_RS10995	COG2201	protein-glutamate methylesterase activity
A0U95_RS11010	COG0457	Tetratricopeptide repeat
A0U95_RS11010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A0U95_RS11030	COG0583	DNA-binding transcription factor activity
A0U95_RS11040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A0U95_RS11045	COG3842	ATPase activity
A0U95_RS11050	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0U95_RS11055	COG1177	transmembrane transport
A0U95_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS11080	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A0U95_RS11085	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS11100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A0U95_RS11110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS11110	COG2205	protein histidine kinase activity
A0U95_RS11130	COG4974	Belongs to the 'phage' integrase family
A0U95_RS11135	COG0335	large ribosomal subunit rRNA binding
A0U95_RS11140	COG0336	Belongs to the RNA methyltransferase TrmD family
A0U95_RS11145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0U95_RS11150	COG0228	four-way junction DNA binding
A0U95_RS11155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0U95_RS11165	COG4536	flavin adenine dinucleotide binding
A0U95_RS11175	COG0477	Major facilitator Superfamily
A0U95_RS11180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0U95_RS11195	COG4106	trans-aconitate 2-methyltransferase activity
A0U95_RS11200	COG0500	methyltransferase
A0U95_RS11205	COG0590	tRNA wobble adenosine to inosine editing
A0U95_RS11235	COG0431	NADPH-dependent FMN reductase
A0U95_RS11245	COG0477	Major facilitator Superfamily
A0U95_RS11250	COG2207	Transcriptional regulator
A0U95_RS11255	COG1881	PFAM PEBP family protein
A0U95_RS11270	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0U95_RS11330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0U95_RS11330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0U95_RS11335	COG4580	involved in the transport of maltose and maltodextrins
A0U95_RS11340	COG0366	Alpha amylase catalytic
A0U95_RS11345	COG1263	PTS System
A0U95_RS11345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0U95_RS11350	COG2188	Transcriptional regulator
A0U95_RS11360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0U95_RS11360	COG0519	Catalyzes the synthesis of GMP from XMP
A0U95_RS11385	COG1570	exodeoxyribonuclease VII activity
A0U95_RS11390	COG0739	heme binding
A0U95_RS11395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A0U95_RS11405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U95_RS11410	COG0436	Aminotransferase
A0U95_RS11415	COG1160	GTP binding
A0U95_RS11430	COG0124	histidyl-tRNA synthetase
A0U95_RS11435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A0U95_RS11440	COG1426	Protein conserved in bacteria
A0U95_RS11450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0U95_RS11455	COG0105	UTP biosynthetic process
A0U95_RS11465	COG0633	Ferredoxin
A0U95_RS11470	COG0443	Heat shock 70 kDa protein
A0U95_RS11475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0U95_RS11480	COG0316	Belongs to the HesB IscA family
A0U95_RS11490	COG1104	cysteine desulfurase activity
A0U95_RS11500	COG1045	serine acetyltransferase
A0U95_RS11515	COG3134	Outer membrane lipoprotein
A0U95_RS11530	COG1862	Preprotein translocase
A0U95_RS11535	COG0343	queuine tRNA-ribosyltransferase activity
A0U95_RS11540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A0U95_RS11635	COG2198	Histidine kinase
A0U95_RS11635	COG2205	protein histidine kinase activity
A0U95_RS11635	COG0784	Response regulator, receiver
A0U95_RS11645	COG3189	MarR family transcriptional regulator
A0U95_RS11695	COG1609	Transcriptional regulator
A0U95_RS11700	COG2186	Transcriptional regulator
A0U95_RS11710	COG4608	Belongs to the ABC transporter superfamily
A0U95_RS11715	COG0444	Belongs to the ABC transporter superfamily
A0U95_RS11720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0U95_RS11725	COG0601	transmembrane transport
A0U95_RS11735	COG4948	Mandelate Racemase Muconate Lactonizing
A0U95_RS11775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0U95_RS11780	COG2909	trisaccharide binding
A0U95_RS11795	COG0318	PFAM AMP-dependent synthetase and ligase
A0U95_RS11800	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS11805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0U95_RS11810	COG2813	Specifically methylates the guanine in position
A0U95_RS11815	COG2119	membrane
A0U95_RS11825	COG0840	transmembrane signaling receptor activity
A0U95_RS11830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U95_RS11835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A0U95_RS11840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A0U95_RS11845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A0U95_RS11850	COG5007	Belongs to the BolA IbaG family
A0U95_RS11870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0U95_RS11875	COG1127	ABC transporter
A0U95_RS11885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A0U95_RS11895	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A0U95_RS11900	COG1137	ATPase activity
A0U95_RS11905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A0U95_RS11910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A0U95_RS11920	COG1660	Displays ATPase and GTPase activities
A0U95_RS11955	COG0312	modulator of DNA gyrase
A0U95_RS11960	COG3028	Belongs to the UPF0307 family
A0U95_RS11965	COG0312	modulator of DNA gyrase
A0U95_RS11970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U95_RS11980	COG1530	ribonuclease E activity
A0U95_RS11985	COG0424	maF-like protein
A0U95_RS11995	COG1792	Involved in formation and maintenance of cell shape
A0U95_RS12000	COG1077	Cell shape determining protein MreB Mrl
A0U95_RS12005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0U95_RS12010	COG0154	amidase activity
A0U95_RS12015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0U95_RS12020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A0U95_RS12030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS12040	COG2721	sulfolactate sulfo-lyase activity
A0U95_RS12045	COG2271	Major facilitator Superfamily
A0U95_RS12055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U95_RS12070	COG4178	(ABC) transporter
A0U95_RS12075	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A0U95_RS12090	COG2801	Transposase and inactivated derivatives
A0U95_RS12090	COG3415	Transposase
A0U95_RS12100	COG0747	negative chemotaxis
A0U95_RS12105	COG0747	negative chemotaxis
A0U95_RS12115	COG0747	negative chemotaxis
A0U95_RS12120	COG0601	transmembrane transport
A0U95_RS12125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0U95_RS12130	COG0444	Belongs to the ABC transporter superfamily
A0U95_RS12135	COG4608	Belongs to the ABC transporter superfamily
A0U95_RS12145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A0U95_RS12170	COG0019	diaminopimelate decarboxylase activity
A0U95_RS12175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A0U95_RS12185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A0U95_RS12185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0U95_RS12185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0U95_RS12190	COG1105	Belongs to the carbohydrate kinase PfkB family
A0U95_RS12195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0U95_RS12195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0U95_RS12200	COG1609	Transcriptional regulator
A0U95_RS12205	COG0084	hydrolase, TatD family'
A0U95_RS12220	COG3023	N-Acetylmuramoyl-L-alanine amidase
A0U95_RS12250	COG1185	polyribonucleotide nucleotidyltransferase activity
A0U95_RS12255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0U95_RS12260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0U95_RS12265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A0U95_RS12270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A0U95_RS12275	COG0195	Participates in both transcription termination and antitermination
A0U95_RS12295	COG0149	triose-phosphate isomerase activity
A0U95_RS12300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0U95_RS12305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A0U95_RS12315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A0U95_RS12330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0U95_RS12335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0U95_RS12340	COG0505	Belongs to the CarA family
A0U95_RS12345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A0U95_RS12350	COG0484	heat shock protein binding
A0U95_RS12355	COG0443	Heat shock 70 kDa protein
A0U95_RS12360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A0U95_RS12365	COG0497	DNA recombination
A0U95_RS12370	COG0735	belongs to the Fur family
A0U95_RS12375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U95_RS12380	COG2914	Belongs to the UPF0125 (RnfH) family
A0U95_RS12390	COG0733	neurotransmitter:sodium symporter activity
A0U95_RS12395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A0U95_RS12400	COG2186	Transcriptional regulator
A0U95_RS12405	COG1620	l-lactate permease
A0U95_RS12410	COG0247	lactate metabolic process
A0U95_RS12415	COG1139	Iron-sulfur cluster binding protein
A0U95_RS12440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A0U95_RS12490	COG2267	carboxylic ester hydrolase activity
A0U95_RS12495	COG2197	response regulator
A0U95_RS12500	COG2267	carboxylic ester hydrolase activity
A0U95_RS12510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0U95_RS12515	COG0444	Belongs to the ABC transporter superfamily
A0U95_RS12520	COG4608	Belongs to the ABC transporter superfamily
A0U95_RS12525	COG0747	negative chemotaxis
A0U95_RS12535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A0U95_RS12550	COG0840	transmembrane signaling receptor activity
A0U95_RS12580	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A0U95_RS12590	COG2610	gluconate transmembrane transporter activity
A0U95_RS12595	COG0659	secondary active sulfate transmembrane transporter activity
A0U95_RS12605	COG0583	DNA-binding transcription factor activity
A0U95_RS12610	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0U95_RS12625	COG0583	DNA-binding transcription factor activity
A0U95_RS12650	COG2885	chlorophyll binding
A0U95_RS12665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0U95_RS12670	COG1074	ATP-dependent DNA helicase activity
A0U95_RS12675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A0U95_RS12720	COG1309	transcriptional regulator
A0U95_RS12725	COG1739	Uncharacterized protein family UPF0029
A0U95_RS12730	COG3845	ABC transporter
A0U95_RS12735	COG4603	Belongs to the binding-protein-dependent transport system permease family
A0U95_RS12740	COG1079	Belongs to the binding-protein-dependent transport system permease family
A0U95_RS12765	COG0387	Pfam Sodium calcium exchanger
A0U95_RS12780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0U95_RS12785	COG0477	Major facilitator Superfamily
A0U95_RS12795	COG0583	DNA-binding transcription factor activity
A0U95_RS12800	COG0604	alcohol dehydrogenase
A0U95_RS12820	COG2217	Heavy metal translocating P-type atpase
A0U95_RS12835	COG2207	Transcriptional regulator
A0U95_RS12845	COG0183	Belongs to the thiolase family
A0U95_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS12870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0U95_RS12885	COG0534	Mate efflux family protein
A0U95_RS12900	COG1166	arginine decarboxylase activity
A0U95_RS12905	COG0023	Translation Initiation Factor
A0U95_RS12930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A0U95_RS12950	COG2264	protein methyltransferase activity
A0U95_RS12960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A0U95_RS12970	COG0138	bifunctional purine biosynthesis protein purh
A0U95_RS12975	COG0151	Belongs to the GarS family
A0U95_RS13000	COG2095	MarC family integral membrane protein
A0U95_RS13035	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A0U95_RS13070	COG1120	ATPase activity
A0U95_RS13080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0U95_RS13085	COG0683	leucine binding
A0U95_RS13100	COG0411	ABC transporter
A0U95_RS13105	COG0410	ABC transporter
A0U95_RS13110	COG0829	nickel cation binding
A0U95_RS13115	COG0831	urea catabolic process
A0U95_RS13130	COG0832	Belongs to the urease beta subunit family
A0U95_RS13135	COG0804	urea catabolic process
A0U95_RS13145	COG0789	Transcriptional regulator
A0U95_RS13150	COG0484	heat shock protein binding
A0U95_RS13155	COG0443	Heat shock 70 kDa protein
A0U95_RS13170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A0U95_RS13175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A0U95_RS13180	COG0583	DNA-binding transcription factor activity
A0U95_RS13190	COG2982	Protein involved in outer membrane biogenesis
A0U95_RS13205	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A0U95_RS13210	COG0830	nickel cation binding
A0U95_RS13215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A0U95_RS13230	COG4221	oxidoreductase activity
A0U95_RS13250	COG0559	Belongs to the binding-protein-dependent transport system permease family
A0U95_RS13260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS13265	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS13270	COG0583	DNA-binding transcription factor activity
A0U95_RS13275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A0U95_RS13280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A0U95_RS13310	COG2308	Evidence 4 Homologs of previously reported genes of
A0U95_RS13310	COG2307	Protein conserved in bacteria
A0U95_RS13330	COG1032	radical SAM domain protein
A0U95_RS13335	COG0305	Participates in initiation and elongation during chromosome replication
A0U95_RS13340	COG0359	binds to the 23S rRNA
A0U95_RS13350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0U95_RS13355	COG0360	Binds together with S18 to 16S ribosomal RNA
A0U95_RS13360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0U95_RS13365	COG0557	exoribonuclease II activity
A0U95_RS13385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A0U95_RS13390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A0U95_RS13395	COG0330	HflC and HflK could
A0U95_RS13400	COG0330	HflC and HflK could
A0U95_RS13405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A0U95_RS13410	COG1923	regulation of RNA biosynthetic process
A0U95_RS13415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A0U95_RS13420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A0U95_RS13425	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0U95_RS13430	COG0802	atpase or kinase
A0U95_RS13435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A0U95_RS13435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0U95_RS13445	COG2860	membrane
A0U95_RS13450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A0U95_RS13455	COG1162	GTPase activity
A0U95_RS13480	COG0688	phosphatidylethanolamine metabolic process
A0U95_RS13490	COG3830	Belongs to the UPF0237 family
A0U95_RS13490	COG0560	Phosphoserine phosphatase
A0U95_RS13525	COG3150	esterase
A0U95_RS13535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A0U95_RS13545	COG0494	nUDIX hydrolase
A0U95_RS13560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A0U95_RS13565	COG1538	Outer membrane efflux protein
A0U95_RS13570	COG1519	Transferase
A0U95_RS13575	COG0583	DNA-binding transcription factor activity
A0U95_RS13590	COG0667	Aldo Keto reductase
A0U95_RS13615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0U95_RS13615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0U95_RS13620	COG0529	Catalyzes the synthesis of activated sulfate
A0U95_RS13630	COG1132	(ABC) transporter
A0U95_RS13640	COG1215	transferase activity, transferring glycosyl groups
A0U95_RS13665	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS13670	COG2192	nodulation
A0U95_RS13695	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS13700	COG0859	PFAM glycosyl transferase family 9
A0U95_RS13705	COG0859	PFAM glycosyl transferase family 9
A0U95_RS13710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A0U95_RS13735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0U95_RS13740	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A0U95_RS13760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0U95_RS13765	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0U95_RS13765	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0U95_RS13765	COG0506	proline dehydrogenase activity
A0U95_RS13770	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS13790	COG3263	regulation of cellular component size
A0U95_RS13795	COG3264	Mechanosensitive ion channel
A0U95_RS13795	COG1196	nuclear chromosome segregation
A0U95_RS13800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A0U95_RS13810	COG4680	protein conserved in bacteria
A0U95_RS13820	COG0583	DNA-binding transcription factor activity
A0U95_RS13825	COG1335	isochorismatase
A0U95_RS13830	COG3118	belongs to the thioredoxin family
A0U95_RS13835	COG1192	Involved in chromosome partitioning
A0U95_RS13850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0U95_RS13855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0U95_RS13865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0U95_RS13875	COG2986	histidine ammonia-lyase
A0U95_RS13915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U95_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS13930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U95_RS13960	COG0583	DNA-binding transcription factor activity
A0U95_RS13965	COG2814	Major facilitator Superfamily
A0U95_RS13970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A0U95_RS13975	COG0493	'glutamate synthase
A0U95_RS13980	COG0069	glutamate synthase activity
A0U95_RS13980	COG0070	glutamate synthase
A0U95_RS13980	COG0067	glutamate synthase
A0U95_RS13990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A0U95_RS13995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A0U95_RS14030	COG0281	malic enzyme
A0U95_RS14040	COG0254	rRNA binding
A0U95_RS14045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A0U95_RS14050	COG0018	arginyl-trna synthetase
A0U95_RS14060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A0U95_RS14065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A0U95_RS14090	COG1309	transcriptional regulator
A0U95_RS14110	COG2226	methyltransferase
A0U95_RS14120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A0U95_RS14125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0U95_RS14130	COG0140	phosphoribosyl-ATP diphosphatase activity
A0U95_RS14135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0U95_RS14155	COG0840	transmembrane signaling receptor activity
A0U95_RS14160	COG0840	transmembrane signaling receptor activity
A0U95_RS14165	COG0840	transmembrane signaling receptor activity
A0U95_RS14175	COG2943	transferase activity, transferring hexosyl groups
A0U95_RS14180	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A0U95_RS14185	COG1490	D-aminoacyl-tRNA deacylase activity
A0U95_RS14190	COG0596	Alpha beta hydrolase
A0U95_RS14195	COG0657	acetylesterase activity
A0U95_RS14215	COG1228	amidohydrolase
A0U95_RS14220	COG2986	histidine ammonia-lyase
A0U95_RS14225	COG2986	histidine ammonia-lyase
A0U95_RS14230	COG0517	IMP dehydrogenase activity
A0U95_RS14230	COG4175	Glycine betaine
A0U95_RS14235	COG4176	ABC-type proline glycine betaine transport system permease component
A0U95_RS14245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A0U95_RS14250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A0U95_RS14260	COG2188	Transcriptional regulator
A0U95_RS14265	COG0402	S-adenosylhomocysteine deaminase activity
A0U95_RS14270	COG3040	lipid binding
A0U95_RS14290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A0U95_RS14310	COG0058	SHG alpha-glucan phosphorylase activity
A0U95_RS14320	COG1217	gtp-binding protein TYPA
A0U95_RS14325	COG0301	tRNA thio-modification
A0U95_RS14325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0U95_RS14350	COG3852	Histidine kinase
A0U95_RS14370	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A0U95_RS14385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A0U95_RS14390	COG4942	peptidase
A0U95_RS14395	COG0793	Belongs to the peptidase S41A family
A0U95_RS14400	COG2861	carbohydrate metabolic process
A0U95_RS14410	COG0107	imidazoleglycerol-phosphate synthase activity
A0U95_RS14415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A0U95_RS14425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0U95_RS14430	COG0131	Imidazoleglycerol-phosphate dehydratase
A0U95_RS14435	COG2223	nitrite transmembrane transporter activity
A0U95_RS14450	COG1194	a g-specific adenine glycosylase
A0U95_RS14455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A0U95_RS14475	COG4804	nuclease activity
A0U95_RS14485	COG4251	negative regulation of phosphorylation
A0U95_RS14540	COG0582	viral genome integration into host DNA
A0U95_RS14585	COG0583	DNA-binding transcription factor activity
A0U95_RS14600	COG5642	Protein of unknown function (DUF2384)
A0U95_RS14645	COG2957	Belongs to the agmatine deiminase family
A0U95_RS14650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0U95_RS14655	COG1088	dTDP-glucose 4,6-dehydratase activity
A0U95_RS14695	COG0494	nUDIX hydrolase
A0U95_RS14700	COG1011	Hydrolase
A0U95_RS14705	COG1652	LysM domain
A0U95_RS14710	COG0583	DNA-binding transcription factor activity
A0U95_RS14715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A0U95_RS14720	COG0243	molybdopterin cofactor binding
A0U95_RS14735	COG1024	Enoyl-CoA hydratase
A0U95_RS14735	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U95_RS14760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A0U95_RS14765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A0U95_RS14770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A0U95_RS14775	COG0189	ligase activity
A0U95_RS14775	COG4067	protein conserved in archaea
A0U95_RS14780	COG0189	ligase activity
A0U95_RS14785	COG2205	protein histidine kinase activity
A0U95_RS14795	COG2183	response to ionizing radiation
A0U95_RS14805	COG2918	glutathione biosynthetic process
A0U95_RS14810	COG4521	taurine ABC transporter
A0U95_RS14815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A0U95_RS14820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0U95_RS14825	COG2175	clavaminate synthase activity
A0U95_RS14830	COG0667	Aldo Keto reductase
A0U95_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS14845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A0U95_RS14850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A0U95_RS14855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS14860	COG0765	amino acid transport
A0U95_RS14865	COG1126	abc transporter atp-binding protein
A0U95_RS14895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0U95_RS14900	COG2011	ABC-type metal ion transport system permease component
A0U95_RS14910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS14920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U95_RS14925	COG0277	FAD linked oxidase domain protein
A0U95_RS14930	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0U95_RS14935	COG3204	pilus organization
A0U95_RS14940	COG3204	pilus organization
A0U95_RS14945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A0U95_RS14950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0U95_RS14965	COG0494	nUDIX hydrolase
A0U95_RS14980	COG0730	response to heat
A0U95_RS14985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A0U95_RS14990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A0U95_RS14995	COG0789	Transcriptional regulator
A0U95_RS15005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0U95_RS15020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A0U95_RS15060	COG0330	HflC and HflK could
A0U95_RS15125	COG1090	epimerase
A0U95_RS15140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0U95_RS15155	COG2175	clavaminate synthase activity
A0U95_RS15160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS15165	COG2274	protein secretion by the type I secretion system
A0U95_RS15170	COG1538	Outer membrane efflux protein
A0U95_RS15200	COG5001	Diguanylate cyclase
A0U95_RS15200	COG3300	MHYT domain
A0U95_RS15235	COG0840	transmembrane signaling receptor activity
A0U95_RS15265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U95_RS15290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A0U95_RS15295	COG4208	sulfate ABC transporter
A0U95_RS15300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A0U95_RS15305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A0U95_RS15330	COG2199	diguanylate cyclase activity
A0U95_RS15335	COG2205	protein histidine kinase activity
A0U95_RS15335	COG5002	protein histidine kinase activity
A0U95_RS15335	COG0784	Response regulator, receiver
A0U95_RS15340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0U95_RS15345	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS15360	COG1595	DNA-templated transcription, initiation
A0U95_RS15365	COG2304	oxidoreductase activity
A0U95_RS15375	COG0604	alcohol dehydrogenase
A0U95_RS15375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0U95_RS15375	COG3321	synthase
A0U95_RS15375	COG4221	oxidoreductase activity
A0U95_RS15380	COG0583	DNA-binding transcription factor activity
A0U95_RS15395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U95_RS15405	COG1215	transferase activity, transferring glycosyl groups
A0U95_RS15410	COG1649	PFAM Uncharacterised BCR, COG1649
A0U95_RS15410	COG0726	polysaccharide deacetylase
A0U95_RS15415	COG0457	Tetratricopeptide repeat
A0U95_RS15420	COG5339	Protein conserved in bacteria
A0U95_RS15465	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS15470	COG0583	DNA-binding transcription factor activity
A0U95_RS15490	COG0427	acetyl-CoA hydrolase
A0U95_RS15520	COG0159	tryptophan synthase activity
A0U95_RS15525	COG0133	tryptophan synthase activity
A0U95_RS15540	COG3360	Dodecin
A0U95_RS15550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U95_RS15555	COG1764	response to oxidative stress
A0U95_RS15595	COG3161	chorismate lyase activity
A0U95_RS15600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A0U95_RS15620	COG1253	flavin adenine dinucleotide binding
A0U95_RS15625	COG0739	heme binding
A0U95_RS15640	COG0704	Plays a role in the regulation of phosphate uptake
A0U95_RS15645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0U95_RS15650	COG0581	inorganic phosphate transmembrane transporter activity
A0U95_RS15665	COG0477	Major facilitator Superfamily
A0U95_RS15670	COG1607	acyl-coa hydrolase
A0U95_RS15700	COG0583	DNA-binding transcription factor activity
A0U95_RS15705	COG1027	Aspartate ammonia-lyase
A0U95_RS15710	COG1115	amino acid carrier protein
A0U95_RS15715	COG0252	asparaginase activity
A0U95_RS15740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A0U95_RS15745	COG0339	signal peptide processing
A0U95_RS15750	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A0U95_RS15775	COG0659	secondary active sulfate transmembrane transporter activity
A0U95_RS15785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A0U95_RS15790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A0U95_RS15795	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A0U95_RS15825	COG0109	protoheme IX farnesyltransferase activity
A0U95_RS15890	COG0569	domain protein
A0U95_RS15895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A0U95_RS15900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A0U95_RS15905	COG0242	peptide deformylase activity
A0U95_RS15915	COG0758	DNA mediated transformation
A0U95_RS15920	COG0009	L-threonylcarbamoyladenylate synthase
A0U95_RS15930	COG0408	coproporphyrinogen oxidase activity
A0U95_RS15935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0U95_RS15950	COG3119	arylsulfatase activity
A0U95_RS15970	COG2851	Citrate transporter
A0U95_RS15975	COG0861	Integral membrane protein TerC family
A0U95_RS15985	COG1283	sodium-dependent phosphate transmembrane transporter activity
A0U95_RS15990	COG0612	Peptidase, M16
A0U95_RS16000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0U95_RS16005	COG1127	ABC transporter
A0U95_RS16010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A0U95_RS16010	COG3218	ABC-type transport auxiliary lipoprotein component
A0U95_RS16020	COG0700	Nucleoside recognition
A0U95_RS16025	COG1301	dicarboxylic acid transport
A0U95_RS16035	COG5487	UPF0391 membrane protein
A0U95_RS16045	COG2204	response regulator
A0U95_RS16050	COG5002	protein histidine kinase activity
A0U95_RS16055	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A0U95_RS16060	COG3023	N-Acetylmuramoyl-L-alanine amidase
A0U95_RS16075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A0U95_RS16090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A0U95_RS16110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A0U95_RS16115	COG0735	belongs to the Fur family
A0U95_RS16120	COG1121	(ABC) transporter
A0U95_RS16125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A0U95_RS16140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0U95_RS16145	COG2011	ABC-type metal ion transport system permease component
A0U95_RS16165	COG3842	ATPase activity
A0U95_RS16170	COG1178	ABC-type Fe3 transport system permease component
A0U95_RS16180	COG1840	ABC-type Fe3 transport system, periplasmic component
A0U95_RS16205	COG3706	GGDEF domain
A0U95_RS16210	COG1764	response to oxidative stress
A0U95_RS16220	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS16230	COG0840	transmembrane signaling receptor activity
A0U95_RS16250	COG2818	Glycosylase
A0U95_RS16255	COG0752	glycyl-tRNA synthetase alpha subunit
A0U95_RS16260	COG0751	glycine-tRNA ligase activity
A0U95_RS16275	COG2205	protein histidine kinase activity
A0U95_RS16290	COG0187	DNA topoisomerase II activity
A0U95_RS16295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A0U95_RS16300	COG0592	DNA-directed DNA polymerase activity
A0U95_RS16305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A0U95_RS16310	COG0594	ribonuclease P activity
A0U95_RS16315	COG0706	membrane insertase activity
A0U95_RS16320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A0U95_RS16325	COG0445	tRNA wobble uridine modification
A0U95_RS16330	COG0357	Ribosomal RNA small subunit methyltransferase G
A0U95_RS16335	COG1192	Involved in chromosome partitioning
A0U95_RS16340	COG1475	DNA binding
A0U95_RS16345	COG3312	ion transport
A0U95_RS16350	COG0356	it plays a direct role in the translocation of protons across the membrane
A0U95_RS16360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0U95_RS16365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0U95_RS16370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A0U95_RS16375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A0U95_RS16380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A0U95_RS16385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A0U95_RS16390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0U95_RS16395	COG1349	DNA-binding transcription factor activity
A0U95_RS16400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0U95_RS16425	COG1335	isochorismatase
A0U95_RS16435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A0U95_RS16445	COG0494	nUDIX hydrolase
A0U95_RS16455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0U95_RS16460	COG3119	arylsulfatase activity
A0U95_RS16465	COG0583	DNA-binding transcription factor activity
A0U95_RS16470	COG0625	glutathione transferase activity
A0U95_RS16530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0U95_RS16535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A0U95_RS16535	COG2755	lipolytic protein G-D-S-L family
A0U95_RS16555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U95_RS16575	COG2217	Heavy metal translocating P-type atpase
A0U95_RS16580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0U95_RS16585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0U95_RS16595	COG0803	Belongs to the bacterial solute-binding protein 9 family
A0U95_RS16605	COG1121	(ABC) transporter
A0U95_RS16610	COG1469	GTP cyclohydrolase I activity
A0U95_RS16630	COG0523	cobalamin synthesis protein
A0U95_RS16640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A0U95_RS16645	COG1607	acyl-coa hydrolase
A0U95_RS16650	COG4651	solute:proton antiporter activity
A0U95_RS16650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A0U95_RS16665	COG0210	DNA helicase
A0U95_RS16685	COG0583	DNA-binding transcription factor activity
A0U95_RS16690	COG0439	Biotin carboxylase
A0U95_RS16695	COG5016	pyruvate
A0U95_RS16695	COG0511	ligase activity, forming carbon-carbon bonds
A0U95_RS16705	COG0765	amino acid transport
A0U95_RS16710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS16795	COG3675	Pfam Lipase (class 3)
A0U95_RS16855	COG2204	response regulator
A0U95_RS16885	COG0631	protein serine/threonine phosphatase activity
A0U95_RS16890	COG0515	serine threonine protein kinase
A0U95_RS16890	COG2815	serine threonine protein kinase
A0U95_RS16920	COG3209	COG3209 Rhs family protein
A0U95_RS17020	COG0515	serine threonine protein kinase
A0U95_RS17020	COG2815	serine threonine protein kinase
A0U95_RS17025	COG1136	(ABC) transporter
A0U95_RS17025	COG0577	efflux transmembrane transporter activity
A0U95_RS17060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A0U95_RS17065	COG0583	DNA-binding transcription factor activity
A0U95_RS17075	COG0848	biopolymer transport protein
A0U95_RS17085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U95_RS17105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0U95_RS17110	COG1758	RNA polymerase activity
A0U95_RS17115	COG0194	GDP metabolic process
A0U95_RS17120	COG1561	YicC-like family, N-terminal region
A0U95_RS17125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A0U95_RS17135	COG0708	Exodeoxyribonuclease III
A0U95_RS17140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0U95_RS17145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0U95_RS17150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0U95_RS17155	COG0756	dUTP diphosphatase activity
A0U95_RS17160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A0U95_RS17165	COG2003	Belongs to the UPF0758 family
A0U95_RS17170	COG0747	negative chemotaxis
A0U95_RS17175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0U95_RS17180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0U95_RS17190	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS17200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0U95_RS17205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS17215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS17230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS17235	COG0251	oxidation-reduction process
A0U95_RS17240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0U95_RS17255	COG0427	acetyl-CoA hydrolase
A0U95_RS17260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0U95_RS17270	COG5001	Diguanylate cyclase
A0U95_RS17270	COG3300	MHYT domain
A0U95_RS17275	COG0534	Mate efflux family protein
A0U95_RS17280	COG0583	DNA-binding transcription factor activity
A0U95_RS17285	COG0840	transmembrane signaling receptor activity
A0U95_RS17295	COG0606	chelatase, subunit chli
A0U95_RS17420	COG0606	chelatase, subunit chli
A0U95_RS17425	COG4191	Histidine kinase
A0U95_RS17440	COG0347	Belongs to the P(II) protein family
A0U95_RS17445	COG0004	ammonium transporteR
A0U95_RS17450	COG0432	Pfam Uncharacterised protein family UPF0047
A0U95_RS17460	COG1011	Hydrolase
A0U95_RS17465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A0U95_RS17475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0U95_RS17480	COG0019	diaminopimelate decarboxylase activity
A0U95_RS17485	COG1965	Belongs to the frataxin family
A0U95_RS17495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0U95_RS17500	COG3072	Adenylate cyclase
A0U95_RS17515	COG0625	glutathione transferase activity
A0U95_RS17520	COG0165	Argininosuccinate lyase
A0U95_RS17530	COG0181	hydroxymethylbilane synthase activity
A0U95_RS17545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A0U95_RS17570	COG0488	(ABC) transporter
A0U95_RS17580	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS17605	COG0672	)-iron permease
A0U95_RS17610	COG1671	Belongs to the UPF0178 family
A0U95_RS17615	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A0U95_RS17625	COG0586	Pfam SNARE associated Golgi protein
A0U95_RS17635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A0U95_RS17640	COG0248	Ppx GppA phosphatase
A0U95_RS17645	COG1126	abc transporter atp-binding protein
A0U95_RS17650	COG0765	amino acid transport
A0U95_RS17655	COG0765	amino acid transport
A0U95_RS17660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS17665	COG2186	Transcriptional regulator
A0U95_RS17685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A0U95_RS17700	COG2271	Major facilitator Superfamily
A0U95_RS17715	COG0842	Transport permease protein
A0U95_RS17720	COG1129	ABC transporter
A0U95_RS17720	COG0842	Transport permease protein
A0U95_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS17735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A0U95_RS17755	COG3079	Belongs to the UPF0149 family
A0U95_RS17760	COG0006	proline dipeptidase activity
A0U95_RS17765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS17770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS17780	COG1178	ABC-type Fe3 transport system permease component
A0U95_RS17785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0U95_RS17790	COG0509	glycine decarboxylation via glycine cleavage system
A0U95_RS17805	COG0330	HflC and HflK could
A0U95_RS17810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A0U95_RS17820	COG1522	sequence-specific DNA binding
A0U95_RS17835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0U95_RS17835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A0U95_RS17850	COG0450	alkyl hydroperoxide reductase
A0U95_RS17855	COG0431	NADPH-dependent FMN reductase
A0U95_RS17860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0U95_RS17865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U95_RS17870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0U95_RS17875	COG1116	anion transmembrane transporter activity
A0U95_RS17890	COG0174	glutamine synthetase
A0U95_RS17900	COG0174	glutamine synthetase
A0U95_RS17920	COG3842	ATPase activity
A0U95_RS17925	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0U95_RS17930	COG1177	transmembrane transport
A0U95_RS17935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS17955	COG1388	LysM domain
A0U95_RS17955	COG0741	lytic transglycosylase activity
A0U95_RS17960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0U95_RS17965	COG2124	cytochrome p450
A0U95_RS17995	COG1157	protein secretion by the type III secretion system
A0U95_RS18010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0U95_RS18020	COG4794	Type iii secretion
A0U95_RS18030	COG4792	protein secretion
A0U95_RS18080	COG4669	(LipO)protein
A0U95_RS18125	COG1683	Conserved Protein
A0U95_RS18130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A0U95_RS18145	COG1823	symporter activity
A0U95_RS18155	COG0129	dihydroxy-acid dehydratase activity
A0U95_RS18160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0U95_RS18165	COG0693	protein deglycase activity
A0U95_RS18175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0U95_RS18185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0U95_RS18190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A0U95_RS18195	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A0U95_RS18220	COG0429	hydrolase of the alpha beta-hydrolase fold
A0U95_RS18225	COG0742	ribosomal rna small subunit methyltransferase
A0U95_RS18230	COG0612	Peptidase, M16
A0U95_RS18235	COG0612	Peptidase, M16
A0U95_RS18240	COG0552	protein localization to endoplasmic reticulum
A0U95_RS18245	COG2884	Cell division ATP-binding protein ftsE
A0U95_RS18250	COG2177	Part of the ABC transporter FtsEX involved in
A0U95_RS18260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A0U95_RS18265	COG2363	Small membrane protein
A0U95_RS18275	COG2022	thiamine diphosphate biosynthetic process
A0U95_RS18280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A0U95_RS18290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0U95_RS18295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A0U95_RS18305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U95_RS18305	COG2813	Specifically methylates the guanine in position
A0U95_RS18310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U95_RS18315	COG1872	DUF167
A0U95_RS18340	COG0791	NLP P60 protein
A0U95_RS18350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0U95_RS18360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A0U95_RS18365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A0U95_RS18370	COG1678	Uncharacterized ACR, COG1678
A0U95_RS18380	COG0189	ligase activity
A0U95_RS18405	COG2198	Histidine kinase
A0U95_RS18405	COG0643	Histidine kinase
A0U95_RS18405	COG0784	Response regulator, receiver
A0U95_RS18420	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A0U95_RS18425	COG3052	prosthetic group binding
A0U95_RS18445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A0U95_RS18465	COG1272	protein, Hemolysin III
A0U95_RS18480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS18485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A0U95_RS18500	COG3038	cytochrome b561
A0U95_RS18505	COG2353	YceI-like domain
A0U95_RS18510	COG0513	Belongs to the DEAD box helicase family
A0U95_RS18520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A0U95_RS18525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A0U95_RS18535	COG2116	formate transmembrane transporter activity
A0U95_RS18540	COG2814	Major facilitator Superfamily
A0U95_RS18570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0U95_RS18580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0U95_RS18585	COG0640	Transcriptional regulator
A0U95_RS18595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A0U95_RS18600	COG0126	phosphoglycerate kinase activity
A0U95_RS18645	COG1451	nucleotide metabolic process
A0U95_RS18665	COG1289	transmembrane transporter activity
A0U95_RS18670	COG2081	HI0933 family
A0U95_RS18675	COG0513	Belongs to the DEAD box helicase family
A0U95_RS18680	COG0477	Major facilitator Superfamily
A0U95_RS18695	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A0U95_RS18700	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS18705	COG1309	transcriptional regulator
A0U95_RS18710	COG4175	Glycine betaine
A0U95_RS18715	COG4176	ABC-type proline glycine betaine transport system permease component
A0U95_RS18725	COG1760	l-serine dehydratase
A0U95_RS18750	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U95_RS18755	COG3246	L-lysine catabolic process to acetate
A0U95_RS18805	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0U95_RS18805	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS18810	COG0247	lactate metabolic process
A0U95_RS18810	COG2181	nitrate reductase activity
A0U95_RS18815	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A0U95_RS18830	COG1858	cytochrome C peroxidase
A0U95_RS18840	COG4638	Rieske (2fe-2S)
A0U95_RS18845	COG1017	nitric oxide dioxygenase activity
A0U95_RS18845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0U95_RS18865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0U95_RS18895	COG1063	alcohol dehydrogenase
A0U95_RS18900	COG1278	Cold shock
A0U95_RS18925	COG0204	Acyl-transferase
A0U95_RS18930	COG4067	protein conserved in archaea
A0U95_RS18930	COG0189	ligase activity
A0U95_RS18935	COG0745	RESPONSE REGULATOR receiver
A0U95_RS18940	COG2205	protein histidine kinase activity
A0U95_RS18950	COG4452	Inner membrane protein CreD
A0U95_RS18960	COG0625	glutathione transferase activity
A0U95_RS18965	COG2271	Major facilitator Superfamily
A0U95_RS18980	COG4774	siderophore transport
A0U95_RS18985	COG3712	iron ion homeostasis
A0U95_RS18990	COG1595	DNA-templated transcription, initiation
A0U95_RS19005	COG2204	response regulator
A0U95_RS19010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A0U95_RS19025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A0U95_RS19035	COG3585	molybdate ion transport
A0U95_RS19035	COG2005	Transcriptional regulator
A0U95_RS19045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0U95_RS19050	COG0156	8-amino-7-oxononanoate synthase activity
A0U95_RS19055	COG1073	alpha beta
A0U95_RS19055	COG2226	methyltransferase
A0U95_RS19075	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS19080	COG3706	GGDEF domain
A0U95_RS19085	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS19090	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS19105	COG0535	radical SAM domain protein
A0U95_RS19115	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A0U95_RS19120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0U95_RS19125	COG1025	Belongs to the peptidase M16 family
A0U95_RS19130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U95_RS19150	COG3485	protocatechuate 3,4-dioxygenase
A0U95_RS19155	COG3485	protocatechuate 3,4-dioxygenase
A0U95_RS19160	COG0583	DNA-binding transcription factor activity
A0U95_RS19175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0U95_RS19180	COG0358	DNA primase activity
A0U95_RS19185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A0U95_RS19190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A0U95_RS19195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A0U95_RS19200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0U95_RS19205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A0U95_RS19210	COG0617	tRNA 3'-terminal CCA addition
A0U95_RS19215	COG2719	SpoVR family
A0U95_RS19220	COG2718	Belongs to the UPF0229 family
A0U95_RS19225	COG2766	serine protein kinase
A0U95_RS19230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0U95_RS19235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A0U95_RS19240	COG2967	ApaG domain
A0U95_RS19245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A0U95_RS19250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0U95_RS19255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0U95_RS19260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A0U95_RS19265	COG3178	'Phosphotransferase
A0U95_RS19270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A0U95_RS19275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0U95_RS19290	COG2197	response regulator
A0U95_RS19295	COG3842	ATPase activity
A0U95_RS19305	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0U95_RS19315	COG1454	alcohol dehydrogenase
A0U95_RS19325	COG0546	phosphoglycolate phosphatase activity
A0U95_RS19330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A0U95_RS19340	COG0512	Glutamine amidotransferase of anthranilate synthase
A0U95_RS19345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0U95_RS19350	COG0134	indole-3-glycerol-phosphate synthase activity
A0U95_RS19365	COG1765	OsmC-like protein
A0U95_RS19370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A0U95_RS19375	COG0537	adenosine 5'-monophosphoramidase activity
A0U95_RS19395	COG1981	membrane
A0U95_RS19400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0U95_RS19405	COG0316	Belongs to the HesB IscA family
A0U95_RS19410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A0U95_RS19415	COG0739	heme binding
A0U95_RS19420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A0U95_RS19450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A0U95_RS19450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A0U95_RS19455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A0U95_RS19480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0U95_RS19500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0U95_RS19505	COG0081	regulation of translation
A0U95_RS19510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A0U95_RS19515	COG0222	ribosome binding
A0U95_RS19520	COG0085	RNA polymerase activity
A0U95_RS19525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0U95_RS19530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A0U95_RS19535	COG0049	tRNA binding
A0U95_RS19540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0U95_RS19545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0U95_RS19550	COG0051	transcription antitermination factor activity, RNA binding
A0U95_RS19555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A0U95_RS19560	COG0088	Forms part of the polypeptide exit tunnel
A0U95_RS19565	COG0089	rRNA binding
A0U95_RS19570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A0U95_RS19575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A0U95_RS19580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A0U95_RS19585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A0U95_RS19590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A0U95_RS19595	COG0255	Belongs to the universal ribosomal protein uL29 family
A0U95_RS19600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A0U95_RS19605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A0U95_RS19610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A0U95_RS19615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0U95_RS19620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A0U95_RS19625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0U95_RS19630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0U95_RS19635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A0U95_RS19640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0U95_RS19645	COG1841	ribosomal large subunit assembly
A0U95_RS19650	COG0200	Binds to the 23S rRNA
A0U95_RS19660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A0U95_RS19665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A0U95_RS19670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0U95_RS19675	COG0202	RNA polymerase activity
A0U95_RS19680	COG0203	ribosomal protein L17
A0U95_RS19690	COG2193	ferroxidase activity
A0U95_RS19695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A0U95_RS19700	COG2814	Major facilitator Superfamily
A0U95_RS19705	COG0629	single-stranded DNA binding
A0U95_RS19730	COG1335	isochorismatase
A0U95_RS19750	COG0392	lysyltransferase activity
A0U95_RS19760	COG3568	Endonuclease Exonuclease Phosphatase
A0U95_RS19770	COG0668	transmembrane transport
A0U95_RS19775	COG1201	RNA secondary structure unwinding
A0U95_RS19785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U95_RS19790	COG3047	cAMP biosynthetic process
A0U95_RS19820	COG3118	belongs to the thioredoxin family
A0U95_RS19825	COG2264	protein methyltransferase activity
A0U95_RS19835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U95_RS19840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0U95_RS19840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0U95_RS19855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0U95_RS19860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0U95_RS19870	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A0U95_RS19880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0U95_RS19890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A0U95_RS19895	COG4206	TonB-dependent receptor
A0U95_RS19900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0U95_RS19905	COG0142	geranyltranstransferase activity
A0U95_RS19910	COG1722	exodeoxyribonuclease VII activity
A0U95_RS19920	COG4676	Protein conserved in bacteria
A0U95_RS19925	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
A0U95_RS19940	COG5445	Predicted secreted protein (DUF2300)
A0U95_RS19945	COG4676	Protein conserved in bacteria
A0U95_RS19950	COG3789	protein conserved in bacteria
A0U95_RS19955	COG1842	Phage shock protein A
A0U95_RS19980	COG0754	glutathionylspermidine amidase activity
A0U95_RS19985	COG4589	Belongs to the CDS family
A0U95_RS20000	COG2453	phosphatase
A0U95_RS20000	COG0671	phosphoesterase, PA-phosphatase related
A0U95_RS20005	COG2267	carboxylic ester hydrolase activity
A0U95_RS20010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A0U95_RS20035	COG0833	amino acid
A0U95_RS20040	COG0583	DNA-binding transcription factor activity
A0U95_RS20050	COG1522	sequence-specific DNA binding
A0U95_RS20060	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS20100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A0U95_RS20105	COG3228	Belongs to the MtfA family
A0U95_RS20110	COG0586	Pfam SNARE associated Golgi protein
A0U95_RS20115	COG0456	acetyltransferase
A0U95_RS20120	COG4302	ethanolamine ammonia-lyase activity
A0U95_RS20125	COG4303	Ethanolamine ammonia lyase large subunit
A0U95_RS20140	COG3284	Transcriptional regulator
A0U95_RS20145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A0U95_RS20160	COG0702	epimerase
A0U95_RS20180	COG1346	cytolysis
A0U95_RS20190	COG0586	Pfam SNARE associated Golgi protein
A0U95_RS20195	COG2094	Belongs to the DNA glycosylase MPG family
A0U95_RS20200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A0U95_RS20205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A0U95_RS20215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A0U95_RS20220	COG0768	penicillin binding
A0U95_RS20225	COG0772	Belongs to the SEDS family
A0U95_RS20230	COG2951	lytic endotransglycosylase activity
A0U95_RS20240	COG1686	Belongs to the peptidase S11 family
A0U95_RS20245	COG2921	Belongs to the UPF0250 family
A0U95_RS20250	COG0321	lipoyl(octanoyl) transferase activity
A0U95_RS20255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A0U95_RS20260	COG1619	proteins homologs of microcin C7 resistance protein MccF
A0U95_RS20265	COG2951	lytic endotransglycosylase activity
A0U95_RS20285	COG0495	leucyl-tRNA aminoacylation
A0U95_RS20300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A0U95_RS20305	COG4535	Mg2 and Co2 transporter CorC
A0U95_RS20310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A0U95_RS20315	COG1702	phosphate starvation-inducible protein PhoH
A0U95_RS20320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U95_RS20335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A0U95_RS20340	COG0352	thiamine-phosphate diphosphorylase activity
A0U95_RS20345	COG0351	phosphomethylpyrimidine kinase
A0U95_RS20350	COG0784	Response regulator, receiver
A0U95_RS20350	COG2198	Histidine kinase
A0U95_RS20350	COG2205	protein histidine kinase activity
A0U95_RS20355	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS20360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0U95_RS20375	COG1522	sequence-specific DNA binding
A0U95_RS20395	COG1643	Atp-dependent helicase
A0U95_RS20410	COG3416	Protein conserved in bacteria
A0U95_RS20420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0U95_RS20420	COG1199	ATP-dependent helicase activity
A0U95_RS20425	COG1522	sequence-specific DNA binding
A0U95_RS20430	COG0697	spore germination
A0U95_RS20435	COG0513	Belongs to the DEAD box helicase family
A0U95_RS20445	COG0123	including yeast histone deacetylase and acetoin utilization protein
A0U95_RS20455	COG1946	Acyl-CoA thioesterase
A0U95_RS20470	COG2321	neutral zinc metallopeptidase
A0U95_RS20485	COG0477	Major facilitator Superfamily
A0U95_RS20490	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A0U95_RS20490	COG1082	Xylose isomerase domain protein TIM barrel
A0U95_RS20495	COG1309	transcriptional regulator
A0U95_RS20500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0U95_RS20505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A0U95_RS20510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0U95_RS20515	COG2252	PERMEase
A0U95_RS20540	COG2080	2 iron, 2 sulfur cluster binding
A0U95_RS20545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A0U95_RS20550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A0U95_RS20560	COG1271	oxidase subunit
A0U95_RS20565	COG1294	oxidase, subunit
A0U95_RS20575	COG2813	Specifically methylates the guanine in position
A0U95_RS20580	COG2197	response regulator
A0U95_RS20590	COG1970	mechanosensitive ion channel activity
A0U95_RS20615	COG1966	Carbon starvation protein
A0U95_RS20620	COG2879	small protein
A0U95_RS20625	COG0523	cobalamin synthesis protein
A0U95_RS20650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0U95_RS20660	COG0488	(ABC) transporter
A0U95_RS20665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0U95_RS20685	COG1067	ATP-dependent peptidase activity
A0U95_RS20695	COG2862	Uncharacterized protein family, UPF0114
A0U95_RS20700	COG0545	Peptidyl-prolyl cis-trans isomerase
A0U95_RS20705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0U95_RS20710	COG2824	Alkylphosphonate utilization operon protein PhnA
A0U95_RS20715	COG0142	geranyltranstransferase activity
A0U95_RS20720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A0U95_RS20725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A0U95_RS20730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0U95_RS20735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A0U95_RS20740	COG3045	CreA protein
A0U95_RS20750	COG0268	Binds directly to 16S ribosomal RNA
A0U95_RS20760	COG0196	riboflavin kinase activity
A0U95_RS20765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A0U95_RS20770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A0U95_RS20775	COG1047	Peptidyl-prolyl cis-trans
A0U95_RS20780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A0U95_RS20820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS20870	COG0542	response to heat
A0U95_RS20900	COG1252	NADH dehydrogenase
A0U95_RS20940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A0U95_RS20945	COG0237	dephospho-CoA kinase activity
A0U95_RS20950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A0U95_RS20970	COG2823	Periplasmic or secreted lipoprotein
A0U95_RS20985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0U95_RS20990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U95_RS20995	COG0166	Belongs to the GPI family
A0U95_RS21005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A0U95_RS21010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A0U95_RS21020	COG0617	tRNA 3'-terminal CCA addition
A0U95_RS21030	COG4191	Histidine kinase
A0U95_RS21035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U95_RS21040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A0U95_RS21045	COG0436	Aminotransferase
A0U95_RS21050	COG1489	DNA binding
A0U95_RS21060	COG4558	Periplasmic binding protein
A0U95_RS21065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0U95_RS21070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A0U95_RS21095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A0U95_RS21115	COG0028	Belongs to the TPP enzyme family
A0U95_RS21125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0U95_RS21130	COG1183	phosphatidylcholine synthase activity
A0U95_RS21135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A0U95_RS21140	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A0U95_RS21170	COG2995	paraquat-inducible protein a
A0U95_RS21175	COG2995	paraquat-inducible protein a
A0U95_RS21180	COG3008	intermembrane lipid transfer
A0U95_RS21205	COG0456	acetyltransferase
A0U95_RS21215	COG0288	reversible hydration of carbon dioxide
A0U95_RS21230	COG2031	fatty acid transporter
A0U95_RS21240	COG0405	Gamma-glutamyltransferase
A0U95_RS21255	COG2223	nitrite transmembrane transporter activity
A0U95_RS21265	COG0840	transmembrane signaling receptor activity
A0U95_RS21285	COG0193	aminoacyl-tRNA hydrolase activity
A0U95_RS21290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A0U95_RS21295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A0U95_RS21305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0U95_RS21310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A0U95_RS21320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A0U95_RS21325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A0U95_RS21335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A0U95_RS21340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A0U95_RS21360	COG0415	Belongs to the DNA photolyase family
A0U95_RS21370	COG3272	Protein of unknown function (DUF1722)
A0U95_RS21375	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A0U95_RS21380	COG1090	epimerase
A0U95_RS21385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0U95_RS21395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0U95_RS21400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A0U95_RS21410	COG0659	secondary active sulfate transmembrane transporter activity
A0U95_RS21465	COG2135	peptidase activity
A0U95_RS21480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0U95_RS21490	COG0175	sulfate reduction
A0U95_RS21500	COG0204	Acyl-transferase
A0U95_RS21505	COG0857	belongs to the CobB CobQ family
A0U95_RS21505	COG0280	phosphate acetyltransferase
A0U95_RS21515	COG0386	Belongs to the glutathione peroxidase family
A0U95_RS21530	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A0U95_RS21535	COG0492	ferredoxin-NADP+ reductase activity
A0U95_RS21540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0U95_RS21555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0U95_RS21560	COG0302	gtp cyclohydrolase
A0U95_RS21585	COG1366	Belongs to the anti-sigma-factor antagonist family
A0U95_RS21600	COG0596	Alpha beta hydrolase
A0U95_RS21605	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS21610	COG3023	N-Acetylmuramoyl-L-alanine amidase
A0U95_RS21625	COG2197	response regulator
A0U95_RS21640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A0U95_RS21645	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0U95_RS21665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0U95_RS21670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A0U95_RS21675	COG0251	oxidation-reduction process
A0U95_RS21680	COG0579	oxidoreductase
A0U95_RS21685	COG3135	benzoate transporter
A0U95_RS21690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS21725	COG0697	spore germination
A0U95_RS21745	COG0784	Response regulator, receiver
A0U95_RS21745	COG0835	chemotaxis
A0U95_RS21750	COG3604	Transcriptional regulator
A0U95_RS21755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0U95_RS21755	COG1017	nitric oxide dioxygenase activity
A0U95_RS21760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A0U95_RS21765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A0U95_RS21770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A0U95_RS21775	COG1845	cytochrome c oxidase, subunit III
A0U95_RS21785	COG0109	protoheme IX farnesyltransferase activity
A0U95_RS21790	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A0U95_RS21805	COG1801	Protein of unknown function DUF72
A0U95_RS21810	COG3706	GGDEF domain
A0U95_RS21815	COG0583	DNA-binding transcription factor activity
A0U95_RS21820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0U95_RS21830	COG1126	abc transporter atp-binding protein
A0U95_RS21835	COG0765	amino acid transport
A0U95_RS21840	COG0765	amino acid transport
A0U95_RS21850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS21855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0U95_RS21860	COG2423	ornithine cyclodeaminase activity
A0U95_RS21865	COG0006	proline dipeptidase activity
A0U95_RS21870	COG3608	succinylglutamate desuccinylase aspartoacylase
A0U95_RS21875	COG1522	sequence-specific DNA binding
A0U95_RS21880	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS21885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0U95_RS21900	COG0180	Tryptophanyl-tRNA synthetase
A0U95_RS21905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A0U95_RS21915	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS21920	COG0667	Aldo Keto reductase
A0U95_RS21925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0U95_RS21930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0U95_RS21935	COG0723	plastoquinol--plastocyanin reductase activity
A0U95_RS21940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0U95_RS21945	COG2857	Cytochrome c1
A0U95_RS21950	COG0625	glutathione transferase activity
A0U95_RS21955	COG2969	positive regulation of protein catabolic process
A0U95_RS21960	COG2823	Periplasmic or secreted lipoprotein
A0U95_RS21965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A0U95_RS21970	COG0792	nuclease activity
A0U95_RS21975	COG3107	peptidoglycan biosynthetic process
A0U95_RS21990	COG2001	Belongs to the MraZ family
A0U95_RS21995	COG0275	rRNA processing
A0U95_RS22010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0U95_RS22015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A0U95_RS22020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0U95_RS22025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A0U95_RS22030	COG0772	Belongs to the SEDS family
A0U95_RS22035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A0U95_RS22040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A0U95_RS22045	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0U95_RS22060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A0U95_RS22065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A0U95_RS22070	COG5001	Diguanylate cyclase
A0U95_RS22070	COG4251	negative regulation of phosphorylation
A0U95_RS22070	COG3706	GGDEF domain
A0U95_RS22070	COG2203	Gaf domain
A0U95_RS22080	COG5002	protein histidine kinase activity
A0U95_RS22105	COG0583	DNA-binding transcription factor activity
A0U95_RS22125	COG1566	PFAM secretion protein HlyD family protein
A0U95_RS22130	COG0300	oxidoreductase activity
A0U95_RS22145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A0U95_RS22145	COG0662	Cupin 2, conserved barrel domain protein
A0U95_RS22160	COG1696	Membrane protein involved in D-alanine export
A0U95_RS22175	COG3420	alginic acid biosynthetic process
A0U95_RS22185	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A0U95_RS22190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS22195	COG1215	transferase activity, transferring glycosyl groups
A0U95_RS22205	COG3022	response to hydroperoxide
A0U95_RS22210	COG0726	polysaccharide deacetylase
A0U95_RS22215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A0U95_RS22220	COG0315	cyclic pyranopterin monophosphate synthase activity
A0U95_RS22225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A0U95_RS22235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS22255	COG0513	Belongs to the DEAD box helicase family
A0U95_RS22260	COG0400	carboxylic ester hydrolase activity
A0U95_RS22265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS22270	COG4597	amino acid ABC transporter
A0U95_RS22275	COG0765	amino acid transport
A0U95_RS22280	COG1126	abc transporter atp-binding protein
A0U95_RS22295	COG2186	Transcriptional regulator
A0U95_RS22300	COG2807	transmembrane transport
A0U95_RS22310	COG2827	Endonuclease containing a URI domain
A0U95_RS22325	COG3081	Nucleoid-associated protein
A0U95_RS22335	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A0U95_RS22340	COG0525	valine-tRNA ligase activity
A0U95_RS22355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0U95_RS22360	COG0795	lipopolysaccharide-transporting ATPase activity
A0U95_RS22365	COG0795	lipopolysaccharide-transporting ATPase activity
A0U95_RS22370	COG0481	GTPase activity
A0U95_RS22375	COG0681	Belongs to the peptidase S26 family
A0U95_RS22380	COG0571	ribonuclease III activity
A0U95_RS22385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A0U95_RS22390	COG1381	Involved in DNA repair and RecF pathway recombination
A0U95_RS22395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A0U95_RS22400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A0U95_RS22405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0U95_RS22405	COG0047	phosphoribosylformylglycinamidine synthase activity
A0U95_RS22415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0U95_RS22415	COG1263	PTS System
A0U95_RS22415	COG2190	(PTS) system
A0U95_RS22420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0U95_RS22420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0U95_RS22425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0U95_RS22430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A0U95_RS22435	COG2188	Transcriptional regulator
A0U95_RS22465	COG0494	nUDIX hydrolase
A0U95_RS22485	COG4628	conserved protein (DUF2132)
A0U95_RS22495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A0U95_RS22510	COG2375	cellular response to nickel ion
A0U95_RS22515	COG1695	Transcriptional regulator
A0U95_RS22560	COG1113	amino acid transport
A0U95_RS22570	COG0069	glutamate synthase activity
A0U95_RS22580	COG3852	Histidine kinase
A0U95_RS22585	COG1858	cytochrome C peroxidase
A0U95_RS22610	COG0494	nUDIX hydrolase
A0U95_RS22615	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS22630	COG0583	DNA-binding transcription factor activity
A0U95_RS22635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A0U95_RS22640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U95_RS22645	COG0583	DNA-binding transcription factor activity
A0U95_RS22655	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS22675	COG3842	ATPase activity
A0U95_RS22680	COG2207	Transcriptional regulator
A0U95_RS22705	COG0477	Major facilitator Superfamily
A0U95_RS22715	COG4191	Histidine kinase
A0U95_RS22735	COG3706	GGDEF domain
A0U95_RS22745	COG1024	Enoyl-CoA hydratase
A0U95_RS22795	COG0714	Associated with various cellular activities
A0U95_RS22820	COG2925	Exonuclease
A0U95_RS22845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A0U95_RS22845	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS22850	COG0433	COG0433 Predicted ATPase
A0U95_RS22860	COG0653	protein targeting
A0U95_RS22865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A0U95_RS22875	COG0494	nUDIX hydrolase
A0U95_RS22880	COG2096	Adenosyltransferase
A0U95_RS22885	COG4191	Histidine kinase
A0U95_RS22885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS22895	COG1666	GTP binding
A0U95_RS22900	COG0668	transmembrane transport
A0U95_RS22915	COG2900	Belongs to the SlyX family
A0U95_RS22925	COG0783	Belongs to the Dps family
A0U95_RS22940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A0U95_RS22945	COG0217	transcriptional regulatory protein
A0U95_RS22950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A0U95_RS22955	COG0632	four-way junction helicase activity
A0U95_RS22960	COG2255	four-way junction helicase activity
A0U95_RS22965	COG0824	Thioesterase
A0U95_RS22985	COG0823	Involved in the tonB-independent uptake of proteins
A0U95_RS22990	COG2885	chlorophyll binding
A0U95_RS22995	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A0U95_RS23000	COG0602	queuosine metabolic process
A0U95_RS23005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A0U95_RS23020	COG2807	transmembrane transport
A0U95_RS23040	COG2132	Multicopper oxidase
A0U95_RS23045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A0U95_RS23055	COG1278	Cold shock
A0U95_RS23065	COG1760	l-serine dehydratase
A0U95_RS23070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0U95_RS23070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0U95_RS23075	COG0509	glycine decarboxylation via glycine cleavage system
A0U95_RS23085	COG0583	DNA-binding transcription factor activity
A0U95_RS23095	COG2910	NAD(P)H-binding
A0U95_RS23115	COG1126	abc transporter atp-binding protein
A0U95_RS23120	COG0765	amino acid transport
A0U95_RS23125	COG0765	amino acid transport
A0U95_RS23145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A0U95_RS23155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0U95_RS23170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0U95_RS23180	COG0243	molybdopterin cofactor binding
A0U95_RS23185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A0U95_RS23200	COG0450	alkyl hydroperoxide reductase
A0U95_RS23205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0U95_RS23210	COG0418	dihydroorotase activity
A0U95_RS23220	COG0137	argininosuccinate synthase activity
A0U95_RS23230	COG2197	response regulator
A0U95_RS23240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0U95_RS23250	COG4659	FMN binding
A0U95_RS23255	COG4658	electron transport chain
A0U95_RS23260	COG2878	Part of a membrane complex involved in electron transport
A0U95_RS23265	COG4657	Part of a membrane complex involved in electron transport
A0U95_RS23270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U95_RS23270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U95_RS23275	COG0489	protein tyrosine kinase activity
A0U95_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS23295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A0U95_RS23300	COG0459	protein refolding
A0U95_RS23310	COG1368	sulfuric ester hydrolase activity
A0U95_RS23320	COG0642	Histidine kinase
A0U95_RS23330	COG3642	lipopolysaccharide core region biosynthetic process
A0U95_RS23340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0U95_RS23345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS23370	COG0642	Histidine kinase
A0U95_RS23380	COG0745	RESPONSE REGULATOR receiver
A0U95_RS23390	COG2350	Protein conserved in bacteria
A0U95_RS23395	COG2917	probably involved in intracellular septation
A0U95_RS23400	COG0613	PHP domain protein
A0U95_RS23405	COG0009	L-threonylcarbamoyladenylate synthase
A0U95_RS23415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A0U95_RS23430	COG1113	amino acid transport
A0U95_RS23465	COG0584	glycerophosphoryl diester phosphodiesterase
A0U95_RS23475	COG2329	Antibiotic biosynthesis monooxygenase
A0U95_RS23480	COG0504	CTP synthase activity
A0U95_RS23545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U95_RS23560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U95_RS23590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0U95_RS23605	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS23610	COG3724	N-succinylarginine dihydrolase activity
A0U95_RS23620	COG2988	succinylglutamate desuccinylase activity
A0U95_RS23625	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0U95_RS23630	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A0U95_RS23635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0U95_RS23640	COG0527	aspartate kinase activity
A0U95_RS23645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A0U95_RS23670	COG2239	Acts as a magnesium transporter
A0U95_RS23675	COG1280	lysine exporter protein (LysE YggA)
A0U95_RS23695	COG2831	hemolysin activation secretion protein
A0U95_RS23705	COG3210	domain, Protein
A0U95_RS23730	COG5002	protein histidine kinase activity
A0U95_RS23740	COG0477	Major facilitator Superfamily
A0U95_RS23745	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A0U95_RS23755	COG2747	anti-sigma28 factor FlgM
A0U95_RS23765	COG0784	Response regulator, receiver
A0U95_RS23765	COG0835	chemotaxis
A0U95_RS23770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A0U95_RS23775	COG1815	bacterial-type flagellum-dependent cell motility
A0U95_RS23795	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
A0U95_RS23800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS23815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U95_RS23815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U95_RS23820	COG0745	RESPONSE REGULATOR receiver
A0U95_RS23825	COG2205	protein histidine kinase activity
A0U95_RS23855	COG4977	sequence-specific DNA binding
A0U95_RS23855	COG1917	Cupin 2, conserved barrel domain protein
A0U95_RS23865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A0U95_RS23870	COG3091	SprT-like family
A0U95_RS23880	COG0037	tRNA processing
A0U95_RS23900	COG1393	Belongs to the ArsC family
A0U95_RS23905	COG3118	belongs to the thioredoxin family
A0U95_RS23920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0U95_RS23925	COG2205	protein histidine kinase activity
A0U95_RS23925	COG0784	Response regulator, receiver
A0U95_RS23925	COG5002	protein histidine kinase activity
A0U95_RS23935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0U95_RS23940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0U95_RS23945	COG3956	TIGRFAM MazG family protein
A0U95_RS23965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A0U95_RS23970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A0U95_RS23980	COG0628	permease
A0U95_RS23985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A0U95_RS23990	COG0791	NLP P60 protein
A0U95_RS23995	COG0791	NLP P60 protein
A0U95_RS24015	COG1797	cobyrinic acid a,c-diamide synthase activity
A0U95_RS24020	COG0778	Nitroreductase
A0U95_RS24035	COG1492	cobalamin metabolic process
A0U95_RS24045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A0U95_RS24050	COG0406	alpha-ribazole phosphatase activity
A0U95_RS24055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A0U95_RS24060	COG1846	Transcriptional regulator
A0U95_RS24075	COG2067	long-chain fatty acid transport protein
A0U95_RS24100	COG2205	protein histidine kinase activity
A0U95_RS24130	COG2076	Multidrug Resistance protein
A0U95_RS24135	COG0385	Bile acid
A0U95_RS24140	COG2974	May be involved in recombination
A0U95_RS24170	COG2010	Cytochrome c
A0U95_RS24175	COG0545	Peptidyl-prolyl cis-trans isomerase
A0U95_RS24200	COG3209	COG3209 Rhs family protein
A0U95_RS24215	COG2200	EAL domain
A0U95_RS24220	COG0793	Belongs to the peptidase S41A family
A0U95_RS24225	COG3321	synthase
A0U95_RS24225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0U95_RS24225	COG4221	oxidoreductase activity
A0U95_RS24225	COG0604	alcohol dehydrogenase
A0U95_RS24245	COG0560	Phosphoserine phosphatase
A0U95_RS24250	COG3842	ATPase activity
A0U95_RS24260	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0U95_RS24285	COG1362	aminopeptidase activity
A0U95_RS24290	COG0564	pseudouridine synthase activity
A0U95_RS24295	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A0U95_RS24300	COG2894	cell division
A0U95_RS24305	COG0850	regulation of cytokinetic process
A0U95_RS24310	COG1560	Kdo2-lipid A biosynthetic process
A0U95_RS24330	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A0U95_RS24335	COG4266	Belongs to the allantoicase family
A0U95_RS24365	COG2252	PERMEase
A0U95_RS24375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS24385	COG0302	gtp cyclohydrolase
A0U95_RS24390	COG2840	Smr protein MutS2
A0U95_RS24415	COG1073	alpha beta
A0U95_RS24420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A0U95_RS24430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A0U95_RS24445	COG0318	PFAM AMP-dependent synthetase and ligase
A0U95_RS24465	COG2814	Major facilitator Superfamily
A0U95_RS24470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A0U95_RS24475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U95_RS24485	COG0469	pyruvate kinase activity
A0U95_RS24495	COG2084	Dehydrogenase
A0U95_RS24500	COG3622	Belongs to the hyi family
A0U95_RS24505	COG3960	tartronate-semialdehyde synthase activity
A0U95_RS24520	COG1309	transcriptional regulator
A0U95_RS24525	COG2354	Protein conserved in bacteria
A0U95_RS24530	COG2853	Lipoprotein
A0U95_RS24540	COG2113	Glycine betaine
A0U95_RS24545	COG3162	membrane
A0U95_RS24550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0U95_RS24560	COG2009	succinate dehydrogenase
A0U95_RS24565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A0U95_RS24570	COG1053	succinate dehydrogenase
A0U95_RS24575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0U95_RS24590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U95_RS24595	COG0045	succinate-CoA ligase (ADP-forming) activity
A0U95_RS24635	COG0326	Molecular chaperone. Has ATPase activity
A0U95_RS24645	COG1741	Belongs to the pirin family
A0U95_RS24665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0U95_RS24685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A0U95_RS24720	COG0628	permease
A0U95_RS24740	COG0284	orotidine-5'-phosphate decarboxylase activity
A0U95_RS24745	COG2130	NADP-dependent
A0U95_RS24750	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS24755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS24760	COG0840	transmembrane signaling receptor activity
A0U95_RS24795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS24800	COG0626	cystathionine gamma-synthase activity
A0U95_RS24815	COG1522	sequence-specific DNA binding
A0U95_RS24895	COG4964	Belongs to the GSP D family
A0U95_RS24900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0U95_RS24915	COG1960	acyl-CoA dehydrogenase activity
A0U95_RS24925	COG0625	glutathione transferase activity
A0U95_RS24930	COG1131	(ABC) transporter
A0U95_RS24935	COG0842	Transport permease protein
A0U95_RS24945	COG2333	competence protein COMEC
A0U95_RS24945	COG0658	competence protein
A0U95_RS24950	COG0811	peptide transport
A0U95_RS24955	COG0848	biopolymer transport protein
A0U95_RS24960	COG1663	tetraacyldisaccharide 4'-kinase activity
A0U95_RS24965	COG2835	tetraacyldisaccharide 4'-kinase activity
A0U95_RS24970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A0U95_RS24975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0U95_RS24980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0U95_RS24995	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A0U95_RS24995	COG3608	succinylglutamate desuccinylase aspartoacylase
A0U95_RS25005	COG1530	ribonuclease E activity
A0U95_RS25015	COG0546	phosphoglycolate phosphatase activity
A0U95_RS25020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0U95_RS25020	COG0616	signal peptide processing
A0U95_RS25025	COG0424	maF-like protein
A0U95_RS25035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A0U95_RS25040	COG0416	fatty acid biosynthetic process
A0U95_RS25055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0U95_RS25060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U95_RS25065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0U95_RS25070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A0U95_RS25075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A0U95_RS25090	COG0084	hydrolase, TatD family'
A0U95_RS25100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0U95_RS25115	COG2186	Transcriptional regulator
A0U95_RS25125	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS25130	COG1879	ABC-type sugar transport system periplasmic component
A0U95_RS25135	COG1129	ABC transporter
A0U95_RS25140	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U95_RS25155	COG1418	mRNA catabolic process
A0U95_RS25165	COG0625	glutathione transferase activity
A0U95_RS25170	COG3734	2-keto-3-deoxy-galactonokinase
A0U95_RS25175	COG0800	Aldolase
A0U95_RS25180	COG4948	Mandelate Racemase Muconate Lactonizing
A0U95_RS25185	COG2271	Major facilitator Superfamily
A0U95_RS25190	COG1414	Transcriptional regulator
A0U95_RS25195	COG1064	alcohol dehydrogenase
A0U95_RS25200	COG2207	Transcriptional regulator
A0U95_RS25230	COG2885	chlorophyll binding
A0U95_RS25230	COG3047	cAMP biosynthetic process
A0U95_RS25235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS25265	COG2308	Evidence 4 Homologs of previously reported genes of
A0U95_RS25275	COG1305	Transglutaminase-like
A0U95_RS25285	COG0183	Belongs to the thiolase family
A0U95_RS25290	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U95_RS25290	COG1024	Enoyl-CoA hydratase
A0U95_RS25295	COG0519	Catalyzes the synthesis of GMP from XMP
A0U95_RS25295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0U95_RS25300	COG0598	Magnesium transport protein CorA
A0U95_RS25335	COG2169	Transcriptional regulator
A0U95_RS25340	COG2271	Major facilitator Superfamily
A0U95_RS25350	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS25355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0U95_RS25380	COG5499	transcription regulator containing HTH domain
A0U95_RS25400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0U95_RS25450	COG1522	sequence-specific DNA binding
A0U95_RS25475	COG4191	Histidine kinase
A0U95_RS25475	COG0784	Response regulator, receiver
A0U95_RS25500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U95_RS25505	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS25520	COG1953	Uracil, thiamine, allantoin
A0U95_RS25530	COG0560	Phosphoserine phosphatase
A0U95_RS25540	COG0189	ligase activity
A0U95_RS25550	COG4067	protein conserved in archaea
A0U95_RS25550	COG0189	ligase activity
A0U95_RS25555	COG1802	Transcriptional regulator
A0U95_RS25565	COG0372	Belongs to the citrate synthase family
A0U95_RS25585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A0U95_RS25590	COG1121	(ABC) transporter
A0U95_RS25660	COG4221	oxidoreductase activity
A0U95_RS25665	COG1309	transcriptional regulator
A0U95_RS25675	COG5006	permease, DMT superfamily
A0U95_RS25705	COG3755	Protein conserved in bacteria
A0U95_RS25720	COG2207	Transcriptional regulator
A0U95_RS25725	COG4221	oxidoreductase activity
A0U95_RS25740	COG4977	sequence-specific DNA binding
A0U95_RS25745	COG2267	carboxylic ester hydrolase activity
A0U95_RS25760	COG3387	PFAM Glycoside hydrolase 15-related
A0U95_RS25775	COG4106	trans-aconitate 2-methyltransferase activity
A0U95_RS25780	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A0U95_RS25805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0U95_RS25835	COG1538	Outer membrane efflux protein
A0U95_RS25840	COG1136	(ABC) transporter
A0U95_RS25840	COG0577	efflux transmembrane transporter activity
A0U95_RS25845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U95_RS25860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS25860	COG2205	protein histidine kinase activity
A0U95_RS25870	COG2197	response regulator
A0U95_RS25885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS25890	COG2223	nitrite transmembrane transporter activity
A0U95_RS25895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0U95_RS25900	COG0402	S-adenosylhomocysteine deaminase activity
A0U95_RS25905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A0U95_RS25915	COG0720	synthase
A0U95_RS25945	COG2056	Na+-H+ antiporter family
A0U95_RS25955	COG0826	peptidase U32
A0U95_RS25960	COG0628	permease
A0U95_RS25980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A0U95_RS25985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0U95_RS26005	COG0556	nucleotide-excision repair
A0U95_RS26010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U95_RS26040	COG2267	carboxylic ester hydrolase activity
A0U95_RS26050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A0U95_RS26070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A0U95_RS26075	COG0066	3-isopropylmalate dehydratase activity
A0U95_RS26080	COG2226	methyltransferase
A0U95_RS26085	COG0473	3-isopropylmalate dehydrogenase activity
A0U95_RS26110	COG0135	phosphoribosylanthranilate isomerase activity
A0U95_RS26115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A0U95_RS26120	COG0285	dihydrofolate synthase activity
A0U95_RS26125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A0U95_RS26130	COG1286	toxin biosynthetic process
A0U95_RS26165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS26205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A0U95_RS26215	COG1741	Belongs to the pirin family
A0U95_RS26220	COG2433	Pfam Transposase IS66
A0U95_RS26280	COG0583	DNA-binding transcription factor activity
A0U95_RS26345	COG3284	Transcriptional regulator
A0U95_RS26350	COG3842	ATPase activity
A0U95_RS26355	COG3842	ATPase activity
A0U95_RS26365	COG0395	ABC-type sugar transport system, permease component
A0U95_RS26420	COG1216	Glycosyl transferase, family 2
A0U95_RS26470	COG1136	(ABC) transporter
A0U95_RS26495	COG5383	Protein conserved in bacteria
A0U95_RS26500	COG0247	lactate metabolic process
A0U95_RS26505	COG0277	FAD linked oxidase domain protein
A0U95_RS26510	COG0277	FAD linked oxidase domain protein
A0U95_RS26515	COG2267	carboxylic ester hydrolase activity
A0U95_RS26520	COG3706	GGDEF domain
A0U95_RS26535	COG0583	DNA-binding transcription factor activity
A0U95_RS26550	COG0708	Exodeoxyribonuclease III
A0U95_RS26560	COG0729	surface antigen
A0U95_RS26570	COG1846	Transcriptional regulator
A0U95_RS26580	COG1566	PFAM secretion protein HlyD family protein
A0U95_RS26585	COG2814	Major facilitator Superfamily
A0U95_RS26590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U95_RS26600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U95_RS26605	COG0215	cysteine-tRNA ligase activity
A0U95_RS26615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A0U95_RS26645	COG1129	ABC transporter
A0U95_RS26650	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U95_RS26655	COG1609	Transcriptional regulator
A0U95_RS26660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U95_RS26665	COG1869	D-ribose catabolic process
A0U95_RS26690	COG1278	Cold shock
A0U95_RS26700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0U95_RS26705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A0U95_RS26710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A0U95_RS26715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A0U95_RS26720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0U95_RS26725	COG0072	phenylalanine-tRNA ligase activity
A0U95_RS26730	COG0776	regulation of translation
A0U95_RS26750	COG0784	Response regulator, receiver
A0U95_RS26750	COG2205	protein histidine kinase activity
A0U95_RS26750	COG2198	Histidine kinase
A0U95_RS26770	COG3842	ATPase activity
A0U95_RS26775	COG0410	ABC transporter
A0U95_RS26785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U95_RS26805	COG0436	Aminotransferase
A0U95_RS26815	COG0511	ligase activity, forming carbon-carbon bonds
A0U95_RS26825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A0U95_RS26830	COG1984	allophanate hydrolase subunit 2
A0U95_RS26840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A0U95_RS26845	COG4221	oxidoreductase activity
A0U95_RS26855	COG0765	amino acid transport
A0U95_RS26860	COG1126	abc transporter atp-binding protein
A0U95_RS26865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS26885	COG2072	flavoprotein involved in K transport
A0U95_RS26890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A0U95_RS26930	COG2271	Major facilitator Superfamily
A0U95_RS26960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A0U95_RS26965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U95_RS26995	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS27020	COG0438	transferase activity, transferring glycosyl groups
A0U95_RS27040	COG0745	RESPONSE REGULATOR receiver
A0U95_RS27045	COG2205	protein histidine kinase activity
A0U95_RS27055	COG0745	RESPONSE REGULATOR receiver
A0U95_RS27060	COG2205	protein histidine kinase activity
A0U95_RS27105	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0U95_RS27145	COG4638	Rieske (2fe-2S)
A0U95_RS27150	COG0583	DNA-binding transcription factor activity
A0U95_RS27155	COG4175	Glycine betaine
A0U95_RS27155	COG3448	diguanylate cyclase activity
A0U95_RS27160	COG4176	ABC-type proline glycine betaine transport system permease component
A0U95_RS27170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A0U95_RS27180	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A0U95_RS27185	COG1902	pentaerythritol trinitrate reductase activity
A0U95_RS27185	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0U95_RS27200	COG2113	Glycine betaine
A0U95_RS27240	COG1741	Belongs to the pirin family
A0U95_RS27285	COG1335	isochorismatase
A0U95_RS27290	COG0583	DNA-binding transcription factor activity
A0U95_RS27300	COG0579	oxidoreductase
A0U95_RS27335	COG0713	ATP synthesis coupled electron transport
A0U95_RS27345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U95_RS27350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A0U95_RS27355	COG1034	ATP synthesis coupled electron transport
A0U95_RS27370	COG0649	NAD binding
A0U95_RS27370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U95_RS27375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U95_RS27380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U95_RS27385	COG0840	transmembrane signaling receptor activity
A0U95_RS27390	COG2224	Isocitrate lyase
A0U95_RS27400	COG2153	protein acetylation
A0U95_RS27405	COG2850	peptidyl-arginine hydroxylation
A0U95_RS27415	COG2915	High frequency lysogenization protein hflD homolog
A0U95_RS27420	COG0482	sulfurtransferase activity
A0U95_RS27445	COG1278	Cold shock
A0U95_RS27450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A0U95_RS27455	COG0542	response to heat
A0U95_RS27460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A0U95_RS27465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A0U95_RS27470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A0U95_RS27475	COG0492	ferredoxin-NADP+ reductase activity
A0U95_RS27480	COG1674	ftsk spoiiie
A0U95_RS27485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A0U95_RS27490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0U95_RS27495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0U95_RS27500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0U95_RS27505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A0U95_RS27505	COG1648	precorrin-2 dehydrogenase activity
A0U95_RS27510	COG0435	Glutathione S-transferase
A0U95_RS27515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0U95_RS27520	COG2920	part of a sulfur-relay system
A0U95_RS27565	COG1335	isochorismatase
A0U95_RS27590	COG5002	protein histidine kinase activity
A0U95_RS27610	COG2358	TRAP transporter, solute receptor (TAXI family
A0U95_RS27615	COG1609	Transcriptional regulator
A0U95_RS27620	COG0673	inositol 2-dehydrogenase activity
A0U95_RS27630	COG2211	Major facilitator Superfamily
A0U95_RS27645	COG1620	l-lactate permease
A0U95_RS27665	COG0583	DNA-binding transcription factor activity
A0U95_RS27670	COG0667	Aldo Keto reductase
A0U95_RS27690	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0U95_RS27725	COG0251	oxidation-reduction process
A0U95_RS27750	COG0251	oxidation-reduction process
A0U95_RS27760	COG0583	DNA-binding transcription factor activity
A0U95_RS27770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS27775	COG0747	negative chemotaxis
A0U95_RS27780	COG0601	transmembrane transport
A0U95_RS27785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0U95_RS27820	COG0473	3-isopropylmalate dehydrogenase activity
A0U95_RS27830	COG0454	-acetyltransferase
A0U95_RS27835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U95_RS27840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0U95_RS27850	COG1522	sequence-specific DNA binding
A0U95_RS27885	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A0U95_RS27905	COG1942	4-Oxalocrotonate Tautomerase
A0U95_RS27910	COG0583	DNA-binding transcription factor activity
A0U95_RS27920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A0U95_RS27930	COG2814	Major facilitator Superfamily
A0U95_RS27935	COG0583	DNA-binding transcription factor activity
A0U95_RS27950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0U95_RS27970	COG1309	transcriptional regulator
A0U95_RS27975	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS27985	COG0454	-acetyltransferase
A0U95_RS27990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A0U95_RS28000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A0U95_RS28005	COG0583	DNA-binding transcription factor activity
A0U95_RS28035	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0U95_RS28075	COG0583	DNA-binding transcription factor activity
A0U95_RS28080	COG0697	spore germination
A0U95_RS28095	COG4566	intracellular signal transduction
A0U95_RS28100	COG4191	Histidine kinase
A0U95_RS28105	COG1116	anion transmembrane transporter activity
A0U95_RS28110	COG4176	ABC-type proline glycine betaine transport system permease component
A0U95_RS28120	COG1943	Transposase
A0U95_RS28125	COG2201	protein-glutamate methylesterase activity
A0U95_RS28130	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A0U95_RS28140	COG0835	chemotaxis
A0U95_RS28145	COG0840	transmembrane signaling receptor activity
A0U95_RS28150	COG0643	Histidine kinase
A0U95_RS28150	COG2198	Histidine kinase
A0U95_RS28170	COG0534	Mate efflux family protein
A0U95_RS28175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U95_RS28180	COG1611	Belongs to the LOG family
A0U95_RS28190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0U95_RS28210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A0U95_RS28235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0U95_RS28235	COG2169	Transcriptional regulator
A0U95_RS28290	COG3634	alkyl hydroperoxide reductase activity
A0U95_RS28310	COG2200	EAL domain
A0U95_RS28315	COG0583	DNA-binding transcription factor activity
A0U95_RS28335	COG0667	Aldo Keto reductase
A0U95_RS28340	COG2271	Major facilitator Superfamily
A0U95_RS28345	COG3835	regulator
A0U95_RS28350	COG1929	Belongs to the glycerate kinase type-1 family
A0U95_RS28355	COG0840	transmembrane signaling receptor activity
A0U95_RS28375	COG0745	RESPONSE REGULATOR receiver
A0U95_RS28380	COG2205	protein histidine kinase activity
A0U95_RS28390	COG1335	isochorismatase
A0U95_RS28400	COG4335	DNA alkylation repair
A0U95_RS28445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0U95_RS28450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U95_RS28460	COG0022	dehydrogenase e1 component
A0U95_RS28465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0U95_RS28470	COG1522	sequence-specific DNA binding
A0U95_RS28490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A0U95_RS28500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U95_RS28510	COG1309	transcriptional regulator
A0U95_RS28530	COG1953	Uracil, thiamine, allantoin
A0U95_RS28555	COG0745	RESPONSE REGULATOR receiver
A0U95_RS28560	COG3383	formate dehydrogenase (NAD+) activity
A0U95_RS28565	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0U95_RS28570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS28595	COG3718	enzyme involved in inositol metabolism
A0U95_RS28610	COG3962	Belongs to the TPP enzyme family
A0U95_RS28615	COG0673	inositol 2-dehydrogenase activity
A0U95_RS28620	COG0673	inositol 2-dehydrogenase activity
A0U95_RS28630	COG1129	ABC transporter
A0U95_RS28635	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U95_RS28675	COG1320	monovalent cation:proton antiporter activity
A0U95_RS28680	COG2212	antiporter activity
A0U95_RS28690	COG0651	ATP synthesis coupled electron transport
A0U95_RS28695	COG1006	Multisubunit Na H antiporter MnhC subunit
A0U95_RS28700	COG2111	Na H antiporter
A0U95_RS28700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0U95_RS28715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U95_RS28720	COG0673	inositol 2-dehydrogenase activity
A0U95_RS28725	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS28815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0U95_RS28820	COG0814	amino acid
A0U95_RS28845	COG0745	RESPONSE REGULATOR receiver
A0U95_RS28850	COG2205	protein histidine kinase activity
A0U95_RS28860	COG3791	Glutathione-dependent formaldehyde-activating
A0U95_RS28870	COG2169	Transcriptional regulator
A0U95_RS28870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0U95_RS28880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0U95_RS28895	COG2199	diguanylate cyclase activity
A0U95_RS28895	COG2203	Gaf domain
A0U95_RS28905	COG4172	Belongs to the ABC transporter superfamily
A0U95_RS28910	COG4239	(ABC) transporter, permease
A0U95_RS28915	COG4174	ABC transporter (Permease)
A0U95_RS28920	COG4166	transmembrane transport
A0U95_RS28925	COG4166	transmembrane transport
A0U95_RS28930	COG0741	lytic transglycosylase activity
A0U95_RS28930	COG1388	LysM domain
A0U95_RS28935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0U95_RS28945	COG0328	RNA-DNA hybrid ribonuclease activity
A0U95_RS28950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0U95_RS28970	COG0431	NADPH-dependent FMN reductase
A0U95_RS28975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A0U95_RS28985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A0U95_RS28990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A0U95_RS29000	COG3139	Protein of unknown function (DUF1315)
A0U95_RS29010	COG0308	aminopeptidase N
A0U95_RS29030	COG1609	Transcriptional regulator
A0U95_RS29050	COG1012	belongs to the aldehyde dehydrogenase family
A0U95_RS29060	COG2706	6-phosphogluconolactonase activity
A0U95_RS29070	COG0625	glutathione transferase activity
A0U95_RS29080	COG0420	3'-5' exonuclease activity
A0U95_RS29095	COG2304	oxidoreductase activity
A0U95_RS29110	COG0714	Associated with various cellular activities
A0U95_RS29130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U95_RS29140	COG1609	Transcriptional regulator
A0U95_RS29175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U95_RS29265	COG5001	Diguanylate cyclase
A0U95_RS29275	COG0028	Belongs to the TPP enzyme family
A0U95_RS29310	COG3284	Transcriptional regulator
A0U95_RS29315	COG3199	ATP-NAD kinase
A0U95_RS29320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0U95_RS29325	COG0022	dehydrogenase e1 component
A0U95_RS29335	COG1063	alcohol dehydrogenase
A0U95_RS29350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U95_RS29365	COG0765	amino acid transport
A0U95_RS29370	COG0765	amino acid transport
A0U95_RS29380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0U95_RS29385	COG0662	Cupin 2, conserved barrel domain protein
A0U95_RS29385	COG2207	Transcriptional regulator
A0U95_RS29400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U95_RS29410	COG1802	Transcriptional regulator
A0U95_RS29415	COG2814	Major facilitator Superfamily
A0U95_RS29420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U95_RS29430	COG1028	Short-chain dehydrogenase reductase Sdr
A0U95_RS29435	COG1942	4-Oxalocrotonate Tautomerase
A0U95_RS29455	COG0583	DNA-binding transcription factor activity
A0U95_RS29465	COG4948	Mandelate Racemase Muconate Lactonizing
A0U95_RS29480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A0U95_RS29480	COG1648	precorrin-2 dehydrogenase activity