locus-tag	class	description
HLB40_RS00010	COG0592	DNA-directed DNA polymerase activity
HLB40_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLB40_RS00020	COG0187	DNA topoisomerase II activity
HLB40_RS00045	COG5002	protein histidine kinase activity
HLB40_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLB40_RS00060	COG0751	glycine-tRNA ligase activity
HLB40_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
HLB40_RS00070	COG2818	Glycosylase
HLB40_RS00090	COG0569	domain protein
HLB40_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLB40_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS00105	COG0242	peptide deformylase activity
HLB40_RS00115	COG0758	DNA mediated transformation
HLB40_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
HLB40_RS00130	COG0408	coproporphyrinogen oxidase activity
HLB40_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLB40_RS00150	COG3119	arylsulfatase activity
HLB40_RS00175	COG0159	tryptophan synthase activity
HLB40_RS00180	COG0133	tryptophan synthase activity
HLB40_RS00195	COG3360	Dodecin
HLB40_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS00210	COG1764	response to oxidative stress
HLB40_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLB40_RS00250	COG0339	signal peptide processing
HLB40_RS00255	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HLB40_RS00290	COG0659	secondary active sulfate transmembrane transporter activity
HLB40_RS00300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLB40_RS00300	COG1565	acr, cog1565
HLB40_RS00305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB40_RS00310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HLB40_RS00340	COG0109	protoheme IX farnesyltransferase activity
HLB40_RS00355	COG2011	ABC-type metal ion transport system permease component
HLB40_RS00360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLB40_RS00370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB40_RS00375	COG1121	(ABC) transporter
HLB40_RS00380	COG0735	belongs to the Fur family
HLB40_RS00385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HLB40_RS00405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLB40_RS00410	COG3245	cytochrome
HLB40_RS00420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLB40_RS00435	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLB40_RS00440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLB40_RS00445	COG5002	protein histidine kinase activity
HLB40_RS00450	COG2204	response regulator
HLB40_RS00460	COG5487	UPF0391 membrane protein
HLB40_RS00470	COG1301	dicarboxylic acid transport
HLB40_RS00475	COG0700	Nucleoside recognition
HLB40_RS00490	COG1127	ABC transporter
HLB40_RS00495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLB40_RS00505	COG0612	Peptidase, M16
HLB40_RS00510	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLB40_RS00515	COG0861	Integral membrane protein TerC family
HLB40_RS00520	COG2851	Citrate transporter
HLB40_RS00560	COG0427	acetyl-CoA hydrolase
HLB40_RS00580	COG0583	DNA-binding transcription factor activity
HLB40_RS00585	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS00635	COG3712	iron ion homeostasis
HLB40_RS00640	COG1595	DNA-templated transcription, initiation
HLB40_RS00645	COG0840	transmembrane signaling receptor activity
HLB40_RS00655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLB40_RS00675	COG1802	Transcriptional regulator
HLB40_RS00685	COG5001	Diguanylate cyclase
HLB40_RS00685	COG3300	MHYT domain
HLB40_RS00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS00715	COG2175	clavaminate synthase activity
HLB40_RS00725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLB40_RS00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS00740	COG2814	Major facilitator Superfamily
HLB40_RS00815	COG0529	Catalyzes the synthesis of activated sulfate
HLB40_RS00830	COG0330	HflC and HflK could
HLB40_RS00855	COG2026	Addiction module toxin, RelE StbE family
HLB40_RS00865	COG1289	transmembrane transporter activity
HLB40_RS00875	COG1566	PFAM secretion protein HlyD family protein
HLB40_RS00890	COG5339	Protein conserved in bacteria
HLB40_RS00895	COG0457	Tetratricopeptide repeat
HLB40_RS00900	COG1649	PFAM Uncharacterised BCR, COG1649
HLB40_RS00900	COG0726	polysaccharide deacetylase
HLB40_RS00905	COG1215	transferase activity, transferring glycosyl groups
HLB40_RS00915	COG1881	PFAM PEBP family protein
HLB40_RS00920	COG2304	oxidoreductase activity
HLB40_RS00925	COG1595	DNA-templated transcription, initiation
HLB40_RS01000	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB40_RS01010	COG0745	RESPONSE REGULATOR receiver
HLB40_RS01015	COG2199	diguanylate cyclase activity
HLB40_RS01035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLB40_RS01045	COG4208	sulfate ABC transporter
HLB40_RS01050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLB40_RS01085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS01090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS01115	COG4771	TonB-dependent receptor
HLB40_RS01170	COG3209	COG3209 Rhs family protein
HLB40_RS01190	COG2807	transmembrane transport
HLB40_RS01195	COG0590	tRNA wobble adenosine to inosine editing
HLB40_RS01205	COG0583	DNA-binding transcription factor activity
HLB40_RS01240	COG0765	amino acid transport
HLB40_RS01245	COG0765	amino acid transport
HLB40_RS01250	COG1126	abc transporter atp-binding protein
HLB40_RS01255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS01260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLB40_RS01275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS01285	COG2011	ABC-type metal ion transport system permease component
HLB40_RS01290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLB40_RS01295	COG1464	Belongs to the NlpA lipoprotein family
HLB40_RS01315	COG1126	abc transporter atp-binding protein
HLB40_RS01320	COG0765	amino acid transport
HLB40_RS01325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS01330	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLB40_RS01335	COG1045	serine acetyltransferase
HLB40_RS01340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB40_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS01360	COG0583	DNA-binding transcription factor activity
HLB40_RS01375	COG0667	Aldo Keto reductase
HLB40_RS01380	COG1487	ribonuclease activity
HLB40_RS01390	COG2175	clavaminate synthase activity
HLB40_RS01395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS01400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLB40_RS01405	COG4521	taurine ABC transporter
HLB40_RS01410	COG2918	glutathione biosynthetic process
HLB40_RS01420	COG2183	response to ionizing radiation
HLB40_RS01430	COG2205	protein histidine kinase activity
HLB40_RS01435	COG0189	ligase activity
HLB40_RS01440	COG0189	ligase activity
HLB40_RS01440	COG4067	protein conserved in archaea
HLB40_RS01445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLB40_RS01455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLB40_RS01460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HLB40_RS01490	COG0514	ATP-dependent DNA helicase (RecQ)
HLB40_RS01495	COG1024	Enoyl-CoA hydratase
HLB40_RS01495	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS01500	COG0824	Thioesterase
HLB40_RS01515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLB40_RS01525	COG1652	LysM domain
HLB40_RS01530	COG1011	Hydrolase
HLB40_RS01535	COG0494	nUDIX hydrolase
HLB40_RS01570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB40_RS01585	COG2957	Belongs to the agmatine deiminase family
HLB40_RS01620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLB40_RS01625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB40_RS01630	COG1845	cytochrome c oxidase, subunit III
HLB40_RS01635	COG1845	cytochrome c oxidase, subunit III
HLB40_RS01700	COG4215	(ABC) transporter
HLB40_RS01740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HLB40_RS01745	COG1194	a g-specific adenine glycosylase
HLB40_RS01760	COG2223	nitrite transmembrane transporter activity
HLB40_RS01765	COG0131	Imidazoleglycerol-phosphate dehydratase
HLB40_RS01770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLB40_RS01780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLB40_RS01785	COG0107	imidazoleglycerol-phosphate synthase activity
HLB40_RS01795	COG2861	carbohydrate metabolic process
HLB40_RS01800	COG0793	Belongs to the peptidase S41A family
HLB40_RS01805	COG4942	peptidase
HLB40_RS01810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLB40_RS01825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HLB40_RS01845	COG3852	Histidine kinase
HLB40_RS01880	COG0301	tRNA thio-modification
HLB40_RS01880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB40_RS01885	COG1217	gtp-binding protein TYPA
HLB40_RS01895	COG0058	SHG alpha-glucan phosphorylase activity
HLB40_RS01900	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HLB40_RS01935	COG0402	S-adenosylhomocysteine deaminase activity
HLB40_RS01940	COG2188	Transcriptional regulator
HLB40_RS01950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HLB40_RS01955	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLB40_RS01965	COG4176	ABC-type proline glycine betaine transport system permease component
HLB40_RS01970	COG0517	IMP dehydrogenase activity
HLB40_RS01970	COG4175	Glycine betaine
HLB40_RS01975	COG2986	histidine ammonia-lyase
HLB40_RS01980	COG2986	histidine ammonia-lyase
HLB40_RS01985	COG1113	amino acid transport
HLB40_RS01990	COG1228	amidohydrolase
HLB40_RS02000	COG0596	Alpha beta hydrolase
HLB40_RS02005	COG1490	D-aminoacyl-tRNA deacylase activity
HLB40_RS02010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HLB40_RS02015	COG2943	transferase activity, transferring hexosyl groups
HLB40_RS02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS02025	COG0765	amino acid transport
HLB40_RS02035	COG0840	transmembrane signaling receptor activity
HLB40_RS02050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLB40_RS02055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLB40_RS02060	COG0140	phosphoribosyl-ATP diphosphatase activity
HLB40_RS02065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLB40_RS02070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLB40_RS02080	COG2226	methyltransferase
HLB40_RS02125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HLB40_RS02130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HLB40_RS02140	COG0018	arginyl-trna synthetase
HLB40_RS02150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLB40_RS02155	COG0254	rRNA binding
HLB40_RS02165	COG0281	malic enzyme
HLB40_RS02200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLB40_RS02205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLB40_RS02215	COG0067	glutamate synthase
HLB40_RS02215	COG0070	glutamate synthase
HLB40_RS02215	COG0069	glutamate synthase activity
HLB40_RS02220	COG0493	'glutamate synthase
HLB40_RS02225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HLB40_RS02230	COG3111	PFAM Bacterial OB fold (BOF) protein
HLB40_RS02235	COG2814	Major facilitator Superfamily
HLB40_RS02240	COG0583	DNA-binding transcription factor activity
HLB40_RS02255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB40_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS02270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB40_RS02280	COG2226	methyltransferase
HLB40_RS02285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLB40_RS02310	COG2986	histidine ammonia-lyase
HLB40_RS02335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB40_RS02355	COG1192	Involved in chromosome partitioning
HLB40_RS02360	COG3118	belongs to the thioredoxin family
HLB40_RS02365	COG4680	protein conserved in bacteria
HLB40_RS02375	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLB40_RS02380	COG3264	Mechanosensitive ion channel
HLB40_RS02380	COG1196	nuclear chromosome segregation
HLB40_RS02385	COG3263	regulation of cellular component size
HLB40_RS02405	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS02410	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLB40_RS02410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLB40_RS02410	COG0506	proline dehydrogenase activity
HLB40_RS02415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB40_RS02420	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLB40_RS02425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB40_RS02445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLB40_RS02450	COG0859	PFAM glycosyl transferase family 9
HLB40_RS02455	COG0859	PFAM glycosyl transferase family 9
HLB40_RS02460	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS02485	COG2192	nodulation
HLB40_RS02490	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS02515	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS02530	COG1132	(ABC) transporter
HLB40_RS02540	COG0529	Catalyzes the synthesis of activated sulfate
HLB40_RS02545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLB40_RS02545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLB40_RS02555	COG0667	Aldo Keto reductase
HLB40_RS02575	COG1519	Transferase
HLB40_RS02580	COG1538	Outer membrane efflux protein
HLB40_RS02585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HLB40_RS02600	COG0494	nUDIX hydrolase
HLB40_RS02610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLB40_RS02615	COG3150	esterase
HLB40_RS02650	COG3830	Belongs to the UPF0237 family
HLB40_RS02650	COG0560	Phosphoserine phosphatase
HLB40_RS02655	COG0688	phosphatidylethanolamine metabolic process
HLB40_RS02695	COG1162	GTPase activity
HLB40_RS02700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLB40_RS02705	COG2860	membrane
HLB40_RS02715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLB40_RS02715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLB40_RS02720	COG0802	atpase or kinase
HLB40_RS02725	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB40_RS02730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLB40_RS02735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLB40_RS02740	COG1923	regulation of RNA biosynthetic process
HLB40_RS02745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLB40_RS02750	COG0330	HflC and HflK could
HLB40_RS02755	COG0330	HflC and HflK could
HLB40_RS02760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HLB40_RS02765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLB40_RS02770	COG0840	transmembrane signaling receptor activity
HLB40_RS02775	COG1178	ABC-type Fe3 transport system permease component
HLB40_RS02795	COG0557	exoribonuclease II activity
HLB40_RS02800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB40_RS02805	COG0360	Binds together with S18 to 16S ribosomal RNA
HLB40_RS02810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLB40_RS02820	COG0359	binds to the 23S rRNA
HLB40_RS02825	COG0305	Participates in initiation and elongation during chromosome replication
HLB40_RS02830	COG1032	radical SAM domain protein
HLB40_RS02845	COG2308	Evidence 4 Homologs of previously reported genes of
HLB40_RS02845	COG2307	Protein conserved in bacteria
HLB40_RS02875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLB40_RS02880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLB40_RS02885	COG0583	DNA-binding transcription factor activity
HLB40_RS02890	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS02895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS02905	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS02925	COG4221	oxidoreductase activity
HLB40_RS02945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HLB40_RS02950	COG0830	nickel cation binding
HLB40_RS02955	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HLB40_RS02970	COG2982	Protein involved in outer membrane biogenesis
HLB40_RS02975	COG0583	DNA-binding transcription factor activity
HLB40_RS02980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLB40_RS02990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HLB40_RS02995	COG0697	spore germination
HLB40_RS03015	COG0443	Heat shock 70 kDa protein
HLB40_RS03020	COG0484	heat shock protein binding
HLB40_RS03025	COG0789	Transcriptional regulator
HLB40_RS03035	COG0804	urea catabolic process
HLB40_RS03040	COG0832	Belongs to the urease beta subunit family
HLB40_RS03055	COG0831	urea catabolic process
HLB40_RS03060	COG0829	nickel cation binding
HLB40_RS03070	COG0411	ABC transporter
HLB40_RS03085	COG0683	leucine binding
HLB40_RS03090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB40_RS03100	COG1120	ATPase activity
HLB40_RS03140	COG3657	addiction module killer protein
HLB40_RS03150	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HLB40_RS03160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB40_RS03185	COG2095	MarC family integral membrane protein
HLB40_RS03195	COG0151	Belongs to the GarS family
HLB40_RS03200	COG0138	bifunctional purine biosynthesis protein purh
HLB40_RS03210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB40_RS03220	COG2264	protein methyltransferase activity
HLB40_RS03235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLB40_RS03265	COG0023	Translation Initiation Factor
HLB40_RS03270	COG1166	arginine decarboxylase activity
HLB40_RS03275	COG0534	Mate efflux family protein
HLB40_RS03280	COG2373	Large extracellular alpha-helical protein
HLB40_RS03290	COG4953	penicillin-binding protein 1C
HLB40_RS03300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB40_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS03425	COG2217	Heavy metal translocating P-type atpase
HLB40_RS03455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HLB40_RS03460	COG0583	DNA-binding transcription factor activity
HLB40_RS03465	COG0477	Major facilitator Superfamily
HLB40_RS03470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLB40_RS03485	COG0387	Pfam Sodium calcium exchanger
HLB40_RS03520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HLB40_RS03540	COG0811	peptide transport
HLB40_RS03545	COG1079	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS03550	COG4603	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS03555	COG3845	ABC transporter
HLB40_RS03565	COG1309	transcriptional regulator
HLB40_RS03570	COG2233	PERMEase
HLB40_RS03615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HLB40_RS03620	COG1074	ATP-dependent DNA helicase activity
HLB40_RS03625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB40_RS03630	COG1126	abc transporter atp-binding protein
HLB40_RS03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS03655	COG2199	diguanylate cyclase activity
HLB40_RS03695	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HLB40_RS03700	COG3483	tryptophan 2,3-dioxygenase activity
HLB40_RS03705	COG1113	amino acid transport
HLB40_RS03710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB40_RS03710	COG0543	2 iron, 2 sulfur cluster binding
HLB40_RS03715	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLB40_RS03720	COG4638	Rieske (2fe-2S)
HLB40_RS03730	COG1522	sequence-specific DNA binding
HLB40_RS03740	COG1113	amino acid transport
HLB40_RS03745	COG0583	DNA-binding transcription factor activity
HLB40_RS03760	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB40_RS03765	COG0583	DNA-binding transcription factor activity
HLB40_RS03780	COG2610	gluconate transmembrane transporter activity
HLB40_RS03790	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLB40_RS03820	COG0840	transmembrane signaling receptor activity
HLB40_RS03850	COG4160	amino acid transport
HLB40_RS03860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS03865	COG1473	amidohydrolase
HLB40_RS03870	COG0583	DNA-binding transcription factor activity
HLB40_RS03885	COG1309	transcriptional regulator
HLB40_RS03910	COG0583	DNA-binding transcription factor activity
HLB40_RS03945	COG0247	lactate metabolic process
HLB40_RS03950	COG1620	l-lactate permease
HLB40_RS03955	COG2186	Transcriptional regulator
HLB40_RS03960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLB40_RS03965	COG0733	neurotransmitter:sodium symporter activity
HLB40_RS03975	COG2914	Belongs to the UPF0125 (RnfH) family
HLB40_RS03980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLB40_RS03990	COG0497	DNA recombination
HLB40_RS03995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLB40_RS04000	COG0443	Heat shock 70 kDa protein
HLB40_RS04005	COG0484	heat shock protein binding
HLB40_RS04010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLB40_RS04015	COG0505	Belongs to the CarA family
HLB40_RS04020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLB40_RS04025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLB40_RS04040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HLB40_RS04050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLB40_RS04055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLB40_RS04060	COG0149	triose-phosphate isomerase activity
HLB40_RS04065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB40_RS04085	COG0195	Participates in both transcription termination and antitermination
HLB40_RS04090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLB40_RS04095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLB40_RS04100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLB40_RS04105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLB40_RS04110	COG1185	polyribonucleotide nucleotidyltransferase activity
HLB40_RS04140	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLB40_RS04155	COG0084	hydrolase, TatD family'
HLB40_RS04160	COG1609	Transcriptional regulator
HLB40_RS04165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLB40_RS04165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB40_RS04170	COG1105	Belongs to the carbohydrate kinase PfkB family
HLB40_RS04175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB40_RS04175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB40_RS04175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLB40_RS04195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLB40_RS04200	COG4774	siderophore transport
HLB40_RS04205	COG3128	pkhd-type hydroxylase
HLB40_RS04215	COG0019	diaminopimelate decarboxylase activity
HLB40_RS04255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLB40_RS04265	COG4608	Belongs to the ABC transporter superfamily
HLB40_RS04270	COG0444	Belongs to the ABC transporter superfamily
HLB40_RS04275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB40_RS04280	COG0601	transmembrane transport
HLB40_RS04285	COG0747	negative chemotaxis
HLB40_RS04295	COG0747	negative chemotaxis
HLB40_RS04300	COG0747	negative chemotaxis
HLB40_RS04310	COG1396	sequence-specific DNA binding
HLB40_RS04310	COG1917	Cupin 2, conserved barrel domain protein
HLB40_RS04325	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HLB40_RS04330	COG4178	(ABC) transporter
HLB40_RS04335	COG2186	Transcriptional regulator
HLB40_RS04350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB40_RS04360	COG2271	Major facilitator Superfamily
HLB40_RS04365	COG2721	sulfolactate sulfo-lyase activity
HLB40_RS04375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB40_RS04385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLB40_RS04390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLB40_RS04395	COG0154	amidase activity
HLB40_RS04400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLB40_RS04405	COG1077	Cell shape determining protein MreB Mrl
HLB40_RS04410	COG1792	Involved in formation and maintenance of cell shape
HLB40_RS04420	COG0424	maF-like protein
HLB40_RS04425	COG1530	ribonuclease E activity
HLB40_RS04435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLB40_RS04440	COG0312	modulator of DNA gyrase
HLB40_RS04445	COG3028	Belongs to the UPF0307 family
HLB40_RS04450	COG0312	modulator of DNA gyrase
HLB40_RS04485	COG1660	Displays ATPase and GTPase activities
HLB40_RS04500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HLB40_RS04505	COG1137	ATPase activity
HLB40_RS04510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HLB40_RS04520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HLB40_RS04530	COG1127	ABC transporter
HLB40_RS04535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLB40_RS04540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLB40_RS04560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLB40_RS04565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLB40_RS04570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLB40_RS04575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLB40_RS04580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB40_RS04590	COG0175	sulfate reduction
HLB40_RS04600	COG0204	Acyl-transferase
HLB40_RS04605	COG0280	phosphate acetyltransferase
HLB40_RS04605	COG0857	belongs to the CobB CobQ family
HLB40_RS04620	COG0386	Belongs to the glutathione peroxidase family
HLB40_RS04635	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HLB40_RS04640	COG0492	ferredoxin-NADP+ reductase activity
HLB40_RS04655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLB40_RS04660	COG0302	gtp cyclohydrolase
HLB40_RS04675	COG0789	Transcriptional regulator
HLB40_RS04685	COG1366	Belongs to the anti-sigma-factor antagonist family
HLB40_RS04695	COG0583	DNA-binding transcription factor activity
HLB40_RS04700	COG1380	Effector of murein hydrolase LrgA
HLB40_RS04705	COG1346	cytolysis
HLB40_RS04715	COG0596	Alpha beta hydrolase
HLB40_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS04740	COG2909	trisaccharide binding
HLB40_RS04750	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HLB40_RS04755	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB40_RS04775	COG2226	methyltransferase
HLB40_RS04825	COG0814	amino acid
HLB40_RS04830	COG1760	l-serine dehydratase
HLB40_RS04835	COG0583	DNA-binding transcription factor activity
HLB40_RS04845	COG4772	TonB-dependent receptor
HLB40_RS04850	COG3712	iron ion homeostasis
HLB40_RS04855	COG1595	DNA-templated transcription, initiation
HLB40_RS04875	COG2027	D-alanyl-D-alanine carboxypeptidase
HLB40_RS04885	COG0697	spore germination
HLB40_RS04890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB40_RS04895	COG0583	DNA-binding transcription factor activity
HLB40_RS04915	COG1566	PFAM secretion protein HlyD family protein
HLB40_RS04935	COG0300	oxidoreductase activity
HLB40_RS04985	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HLB40_RS04985	COG0662	Cupin 2, conserved barrel domain protein
HLB40_RS05000	COG1696	Membrane protein involved in D-alanine export
HLB40_RS05015	COG3420	alginic acid biosynthetic process
HLB40_RS05025	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HLB40_RS05030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS05035	COG1215	transferase activity, transferring glycosyl groups
HLB40_RS05045	COG3022	response to hydroperoxide
HLB40_RS05055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLB40_RS05060	COG0315	cyclic pyranopterin monophosphate synthase activity
HLB40_RS05065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HLB40_RS05075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS05095	COG0513	Belongs to the DEAD box helicase family
HLB40_RS05105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS05110	COG4597	amino acid ABC transporter
HLB40_RS05115	COG0765	amino acid transport
HLB40_RS05120	COG1126	abc transporter atp-binding protein
HLB40_RS05125	COG2944	sequence-specific DNA binding
HLB40_RS05135	COG2186	Transcriptional regulator
HLB40_RS05140	COG2807	transmembrane transport
HLB40_RS05150	COG2827	Endonuclease containing a URI domain
HLB40_RS05170	COG3081	Nucleoid-associated protein
HLB40_RS05180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HLB40_RS05185	COG0525	valine-tRNA ligase activity
HLB40_RS05200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLB40_RS05205	COG0795	lipopolysaccharide-transporting ATPase activity
HLB40_RS05210	COG0795	lipopolysaccharide-transporting ATPase activity
HLB40_RS05215	COG0481	GTPase activity
HLB40_RS05220	COG0681	Belongs to the peptidase S26 family
HLB40_RS05225	COG0571	ribonuclease III activity
HLB40_RS05230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLB40_RS05235	COG1381	Involved in DNA repair and RecF pathway recombination
HLB40_RS05240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLB40_RS05245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HLB40_RS05250	COG0047	phosphoribosylformylglycinamidine synthase activity
HLB40_RS05250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLB40_RS05260	COG1263	PTS System
HLB40_RS05260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB40_RS05260	COG2190	(PTS) system
HLB40_RS05265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB40_RS05265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLB40_RS05270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLB40_RS05275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLB40_RS05280	COG2188	Transcriptional regulator
HLB40_RS05295	COG0494	nUDIX hydrolase
HLB40_RS05315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HLB40_RS05320	COG0477	Major facilitator Superfamily
HLB40_RS05325	COG4536	flavin adenine dinucleotide binding
HLB40_RS05335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLB40_RS05340	COG0228	four-way junction DNA binding
HLB40_RS05345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLB40_RS05350	COG0336	Belongs to the RNA methyltransferase TrmD family
HLB40_RS05355	COG0335	large ribosomal subunit rRNA binding
HLB40_RS05360	COG1607	acyl-coa hydrolase
HLB40_RS05370	COG4974	Belongs to the 'phage' integrase family
HLB40_RS05390	COG2205	protein histidine kinase activity
HLB40_RS05390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS05400	COG2197	response regulator
HLB40_RS05420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLB40_RS05435	COG1902	pentaerythritol trinitrate reductase activity
HLB40_RS05440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HLB40_RS05460	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS05465	COG1177	transmembrane transport
HLB40_RS05470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB40_RS05475	COG3842	ATPase activity
HLB40_RS05480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLB40_RS05485	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS05490	COG0583	DNA-binding transcription factor activity
HLB40_RS05510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB40_RS05510	COG0457	Tetratricopeptide repeat
HLB40_RS05525	COG2201	protein-glutamate methylesterase activity
HLB40_RS05530	COG4251	negative regulation of phosphorylation
HLB40_RS05530	COG3706	GGDEF domain
HLB40_RS05530	COG5001	Diguanylate cyclase
HLB40_RS05530	COG2203	Gaf domain
HLB40_RS05540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLB40_RS05560	COG1073	alpha beta
HLB40_RS05590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLB40_RS05595	COG0563	adenylate kinase activity
HLB40_RS05600	COG1214	PFAM Peptidase M22, glycoprotease
HLB40_RS05610	COG1801	Protein of unknown function DUF72
HLB40_RS05630	COG0742	ribosomal rna small subunit methyltransferase
HLB40_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS05660	COG2937	Belongs to the GPAT DAPAT family
HLB40_RS05675	COG2226	methyltransferase
HLB40_RS05680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB40_RS05690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB40_RS05700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLB40_RS05705	COG2171	N-acyltransferase activity
HLB40_RS05710	COG1393	Belongs to the ArsC family
HLB40_RS05715	COG0025	NhaP-type Na H and K H
HLB40_RS05720	COG0436	Aminotransferase
HLB40_RS05725	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HLB40_RS05730	COG0024	Methionine aminopeptidase
HLB40_RS05735	COG0052	Belongs to the universal ribosomal protein uS2 family
HLB40_RS05740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLB40_RS05745	COG0528	UMP kinase activity
HLB40_RS05750	COG0233	cytoplasmic translational termination
HLB40_RS05755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLB40_RS05765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLB40_RS05785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLB40_RS05790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLB40_RS05795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLB40_RS05800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLB40_RS05805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLB40_RS05810	COG0587	DNA-directed DNA polymerase activity
HLB40_RS05815	COG0825	malonyl-CoA metabolic process
HLB40_RS05820	COG0037	tRNA processing
HLB40_RS05825	COG0504	CTP synthase activity
HLB40_RS05830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HLB40_RS05835	COG0148	phosphopyruvate hydratase activity
HLB40_RS05845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLB40_RS05855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HLB40_RS05860	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB40_RS05865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLB40_RS05870	COG0585	pseudouridine synthase activity
HLB40_RS05875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLB40_RS05880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HLB40_RS05900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLB40_RS05925	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLB40_RS06015	COG4386	tail sheath protein
HLB40_RS06050	COG4381	Mu-like prophage protein gp46
HLB40_RS06105	COG3179	chitinase
HLB40_RS06115	COG1546	Belongs to the CinA family
HLB40_RS06120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLB40_RS06125	COG2137	regulation of response to DNA damage stimulus
HLB40_RS06145	COG3148	PFAM DTW domain containing protein
HLB40_RS06160	COG0583	DNA-binding transcription factor activity
HLB40_RS06180	COG4807	Protein conserved in bacteria
HLB40_RS06185	COG1187	pseudouridine synthase activity
HLB40_RS06195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB40_RS06200	COG3158	transport of potassium into the cell
HLB40_RS06215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HLB40_RS06215	COG0392	lysyltransferase activity
HLB40_RS06230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLB40_RS06240	COG0442	prolyl-tRNA aminoacylation
HLB40_RS06265	COG1278	Cold shock
HLB40_RS06270	COG0717	Belongs to the dCTP deaminase family
HLB40_RS06295	COG4215	(ABC) transporter
HLB40_RS06305	COG2366	antibiotic biosynthetic process
HLB40_RS06310	COG0625	glutathione transferase activity
HLB40_RS06320	COG0653	protein targeting
HLB40_RS06330	COG3012	SEC-C Motif Domain Protein
HLB40_RS06365	COG1199	ATP-dependent helicase activity
HLB40_RS06380	COG2885	chlorophyll binding
HLB40_RS06385	COG0259	pyridoxamine-phosphate oxidase activity
HLB40_RS06400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLB40_RS06410	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HLB40_RS06425	COG0583	DNA-binding transcription factor activity
HLB40_RS06440	COG3220	belongs to the UPF0276 family
HLB40_RS06485	COG2084	Dehydrogenase
HLB40_RS06495	COG0727	PFAM Uncharacterised protein family (UPF0153)
HLB40_RS06500	COG2271	Major facilitator Superfamily
HLB40_RS06505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB40_RS06520	COG0306	phosphate transporter
HLB40_RS06535	COG1414	Transcriptional regulator
HLB40_RS06540	COG2814	Major facilitator Superfamily
HLB40_RS06545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLB40_RS06550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLB40_RS06555	COG0183	Belongs to the thiolase family
HLB40_RS06560	COG3485	protocatechuate 3,4-dioxygenase
HLB40_RS06565	COG3485	protocatechuate 3,4-dioxygenase
HLB40_RS06570	COG0477	Major facilitator Superfamily
HLB40_RS06580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB40_RS06585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB40_RS06605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS06620	COG1902	pentaerythritol trinitrate reductase activity
HLB40_RS06625	COG2814	Major facilitator Superfamily
HLB40_RS06665	COG1473	amidohydrolase
HLB40_RS06675	COG0154	amidase activity
HLB40_RS06700	COG1704	LemA family
HLB40_RS06705	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLB40_RS06720	COG0697	spore germination
HLB40_RS06725	COG0693	protein deglycase activity
HLB40_RS06740	COG1629	transport
HLB40_RS06750	COG1595	DNA-templated transcription, initiation
HLB40_RS06755	COG3422	double-strand break repair
HLB40_RS06760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB40_RS06765	COG0235	Class ii aldolase
HLB40_RS06770	COG1396	sequence-specific DNA binding
HLB40_RS06780	COG1454	alcohol dehydrogenase
HLB40_RS06785	COG3668	Plasmid stabilization system
HLB40_RS06845	COG3938	Belongs to the proline racemase family
HLB40_RS06850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB40_RS06855	COG0531	amino acid
HLB40_RS06865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLB40_RS06885	COG0583	DNA-binding transcription factor activity
HLB40_RS06890	COG5001	Diguanylate cyclase
HLB40_RS06900	COG3468	outer membrane autotransporter barrel domain protein
HLB40_RS06910	COG2267	carboxylic ester hydrolase activity
HLB40_RS06925	COG3706	GGDEF domain
HLB40_RS06940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLB40_RS06990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLB40_RS07020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB40_RS07030	COG0425	Belongs to the sulfur carrier protein TusA family
HLB40_RS07040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLB40_RS07050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB40_RS07055	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HLB40_RS07060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLB40_RS07065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLB40_RS07085	COG1204	response to ionizing radiation
HLB40_RS07145	COG2197	response regulator
HLB40_RS07155	COG3121	Chaperone
HLB40_RS07160	COG3188	usher protein
HLB40_RS07165	COG3121	Chaperone
HLB40_RS07170	COG2831	hemolysin activation secretion protein
HLB40_RS07175	COG3210	domain, Protein
HLB40_RS07205	COG2807	transmembrane transport
HLB40_RS07210	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HLB40_RS07220	COG0583	DNA-binding transcription factor activity
HLB40_RS07230	COG2194	sulfuric ester hydrolase activity
HLB40_RS07245	COG3100	YcgL domain-containing protein
HLB40_RS07250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB40_RS07260	COG2983	Belongs to the UPF0260 family
HLB40_RS07310	COG0121	glutamine amidotransferase
HLB40_RS07320	COG0583	DNA-binding transcription factor activity
HLB40_RS07325	COG2814	Major facilitator Superfamily
HLB40_RS07330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HLB40_RS07335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLB40_RS07340	COG1984	allophanate hydrolase subunit 2
HLB40_RS07350	COG0542	response to heat
HLB40_RS07360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB40_RS07390	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HLB40_RS07395	COG1643	Atp-dependent helicase
HLB40_RS07405	COG1595	DNA-templated transcription, initiation
HLB40_RS07420	COG0814	amino acid
HLB40_RS07440	COG4638	Rieske (2fe-2S)
HLB40_RS07455	COG0477	Major facilitator Superfamily
HLB40_RS07460	COG0583	DNA-binding transcription factor activity
HLB40_RS07470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB40_RS07475	COG1132	(ABC) transporter
HLB40_RS07485	COG2267	carboxylic ester hydrolase activity
HLB40_RS07500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLB40_RS07510	COG0668	transmembrane transport
HLB40_RS07515	COG0513	Belongs to the DEAD box helicase family
HLB40_RS07605	COG1953	Uracil, thiamine, allantoin
HLB40_RS07610	COG0697	spore germination
HLB40_RS07620	COG0583	DNA-binding transcription factor activity
HLB40_RS07630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB40_RS07635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB40_RS07665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS07690	COG3300	MHYT domain
HLB40_RS07690	COG5001	Diguanylate cyclase
HLB40_RS07700	COG2832	Protein of unknown function (DUF454)
HLB40_RS07725	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLB40_RS07740	COG2207	Transcriptional regulator
HLB40_RS07765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB40_RS07785	COG0745	RESPONSE REGULATOR receiver
HLB40_RS07795	COG2350	Protein conserved in bacteria
HLB40_RS07800	COG2917	probably involved in intracellular septation
HLB40_RS07805	COG0613	PHP domain protein
HLB40_RS07810	COG0009	L-threonylcarbamoyladenylate synthase
HLB40_RS07815	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLB40_RS07820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLB40_RS07840	COG1113	amino acid transport
HLB40_RS07865	COG2154	pterin-4-alpha-carbinolamine dehydratase
HLB40_RS07880	COG4786	Flagellar basal body rod
HLB40_RS07890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HLB40_RS07895	COG1706	bacterial-type flagellum-dependent cell motility
HLB40_RS07905	COG1256	bacterial-type flagellum assembly
HLB40_RS07915	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS07915	COG1216	Glycosyl transferase, family 2
HLB40_RS07920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLB40_RS07930	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HLB40_RS07955	COG1216	Glycosyl transferase, family 2
HLB40_RS07955	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS07960	COG1086	Polysaccharide biosynthesis protein
HLB40_RS07965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLB40_RS07970	COG1083	cytidylyl-transferase
HLB40_RS07980	COG2089	acid synthase
HLB40_RS08000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLB40_RS08005	COG1334	flagellar protein FlaG
HLB40_RS08010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLB40_RS08040	COG1677	Flagellar hook-basal body complex protein FliE
HLB40_RS08075	COG0745	RESPONSE REGULATOR receiver
HLB40_RS08155	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HLB40_RS08160	COG0784	Response regulator, receiver
HLB40_RS08160	COG2198	Histidine kinase
HLB40_RS08160	COG0643	Histidine kinase
HLB40_RS08165	COG2201	protein-glutamate methylesterase activity
HLB40_RS08170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLB40_RS08180	COG1192	Involved in chromosome partitioning
HLB40_RS08190	COG0835	chemotaxis
HLB40_RS08210	COG4133	protoheme IX ABC transporter activity
HLB40_RS08230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HLB40_RS08235	COG1138	Cytochrome C-type biogenesis protein
HLB40_RS08245	COG3088	subunit of a heme lyase
HLB40_RS08265	COG0583	DNA-binding transcription factor activity
HLB40_RS08270	COG2814	Major facilitator Superfamily
HLB40_RS08290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB40_RS08295	COG4413	Urea transporter
HLB40_RS08300	COG0469	pyruvate kinase activity
HLB40_RS08310	COG2084	Dehydrogenase
HLB40_RS08315	COG3622	Belongs to the hyi family
HLB40_RS08320	COG3960	tartronate-semialdehyde synthase activity
HLB40_RS08330	COG1309	transcriptional regulator
HLB40_RS08335	COG2354	Protein conserved in bacteria
HLB40_RS08340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS08355	COG1834	amidinotransferase
HLB40_RS08365	COG2192	nodulation
HLB40_RS08375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB40_RS08380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS08400	COG2853	Lipoprotein
HLB40_RS08420	COG2113	Glycine betaine
HLB40_RS08425	COG3162	membrane
HLB40_RS08430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB40_RS08440	COG2009	succinate dehydrogenase
HLB40_RS08445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLB40_RS08450	COG1053	succinate dehydrogenase
HLB40_RS08470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB40_RS08475	COG0045	succinate-CoA ligase (ADP-forming) activity
HLB40_RS08515	COG0326	Molecular chaperone. Has ATPase activity
HLB40_RS08525	COG0626	cystathionine gamma-synthase activity
HLB40_RS08535	COG1741	Belongs to the pirin family
HLB40_RS08565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLB40_RS08570	COG5002	protein histidine kinase activity
HLB40_RS08570	COG2205	protein histidine kinase activity
HLB40_RS08570	COG0784	Response regulator, receiver
HLB40_RS08580	COG4771	TonB-dependent receptor
HLB40_RS08585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLB40_RS08595	COG2062	phosphohistidine phosphatase, SixA
HLB40_RS08600	COG1022	Amp-dependent synthetase and ligase
HLB40_RS08620	COG0625	glutathione transferase activity
HLB40_RS08630	COG0628	permease
HLB40_RS08645	COG0284	orotidine-5'-phosphate decarboxylase activity
HLB40_RS08650	COG2130	NADP-dependent
HLB40_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS08660	COG0840	transmembrane signaling receptor activity
HLB40_RS08690	COG2814	Major facilitator Superfamily
HLB40_RS08700	COG3121	Chaperone
HLB40_RS08710	COG2205	protein histidine kinase activity
HLB40_RS08710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS08730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB40_RS08745	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS08755	COG0625	glutathione transferase activity
HLB40_RS08760	COG1131	(ABC) transporter
HLB40_RS08765	COG0842	Transport permease protein
HLB40_RS08780	COG0811	peptide transport
HLB40_RS08785	COG0848	biopolymer transport protein
HLB40_RS08790	COG1663	tetraacyldisaccharide 4'-kinase activity
HLB40_RS08795	COG2835	tetraacyldisaccharide 4'-kinase activity
HLB40_RS08800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HLB40_RS08805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLB40_RS08810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLB40_RS08820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB40_RS08825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HLB40_RS08825	COG3608	succinylglutamate desuccinylase aspartoacylase
HLB40_RS08830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HLB40_RS08835	COG1530	ribonuclease E activity
HLB40_RS08845	COG0546	phosphoglycolate phosphatase activity
HLB40_RS08850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLB40_RS08850	COG0616	signal peptide processing
HLB40_RS08855	COG0424	maF-like protein
HLB40_RS08865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLB40_RS08870	COG0416	fatty acid biosynthetic process
HLB40_RS08885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB40_RS08890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB40_RS08900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLB40_RS08905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLB40_RS08915	COG0084	hydrolase, TatD family'
HLB40_RS08930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB40_RS08945	COG2188	Transcriptional regulator
HLB40_RS08950	COG1397	ADP-ribosylglycohydrolase
HLB40_RS08960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB40_RS08985	COG1418	mRNA catabolic process
HLB40_RS08995	COG3734	2-keto-3-deoxy-galactonokinase
HLB40_RS09000	COG0800	Aldolase
HLB40_RS09005	COG4948	Mandelate Racemase Muconate Lactonizing
HLB40_RS09010	COG2271	Major facilitator Superfamily
HLB40_RS09015	COG1414	Transcriptional regulator
HLB40_RS09020	COG1064	alcohol dehydrogenase
HLB40_RS09025	COG2207	Transcriptional regulator
HLB40_RS09055	COG2885	chlorophyll binding
HLB40_RS09055	COG3047	cAMP biosynthetic process
HLB40_RS09060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS09100	COG0183	Belongs to the thiolase family
HLB40_RS09105	COG1024	Enoyl-CoA hydratase
HLB40_RS09105	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS09110	COG0519	Catalyzes the synthesis of GMP from XMP
HLB40_RS09110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLB40_RS09115	COG0598	Magnesium transport protein CorA
HLB40_RS09125	COG0204	Acyl-transferase
HLB40_RS09180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB40_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS09190	COG0583	DNA-binding transcription factor activity
HLB40_RS09200	COG1953	Uracil, thiamine, allantoin
HLB40_RS09210	COG0560	Phosphoserine phosphatase
HLB40_RS09230	COG4067	protein conserved in archaea
HLB40_RS09230	COG0189	ligase activity
HLB40_RS09235	COG1802	Transcriptional regulator
HLB40_RS09245	COG0372	Belongs to the citrate synthase family
HLB40_RS09260	COG2079	MmgE PrpD family protein
HLB40_RS09265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HLB40_RS09280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLB40_RS09295	COG0668	transmembrane transport
HLB40_RS09305	COG2885	chlorophyll binding
HLB40_RS09305	COG3047	cAMP biosynthetic process
HLB40_RS09310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLB40_RS09315	COG0243	molybdopterin cofactor binding
HLB40_RS09320	COG2146	nitrite reductase [NAD(P)H] activity
HLB40_RS09325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB40_RS09330	COG0515	serine threonine protein kinase
HLB40_RS09330	COG2815	serine threonine protein kinase
HLB40_RS09335	COG2223	nitrite transmembrane transporter activity
HLB40_RS09340	COG3707	response regulator
HLB40_RS09345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS09350	COG0167	dihydroorotate dehydrogenase activity
HLB40_RS09355	COG3130	regulation of translation
HLB40_RS09360	COG0116	Belongs to the methyltransferase superfamily
HLB40_RS09360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB40_RS09370	COG2027	D-alanyl-D-alanine carboxypeptidase
HLB40_RS09375	COG3171	Protein conserved in bacteria
HLB40_RS09380	COG3135	benzoate transporter
HLB40_RS09385	COG1802	Transcriptional regulator
HLB40_RS09390	COG0402	S-adenosylhomocysteine deaminase activity
HLB40_RS09420	COG3115	cell septum assembly
HLB40_RS09425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLB40_RS09480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLB40_RS09485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HLB40_RS09490	COG2130	NADP-dependent
HLB40_RS09495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLB40_RS09500	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS09505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB40_RS09510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB40_RS09530	COG2217	Heavy metal translocating P-type atpase
HLB40_RS09540	COG0348	domain, Protein
HLB40_RS09555	COG2010	Cytochrome c
HLB40_RS09570	COG3278	Belongs to the heme-copper respiratory oxidase family
HLB40_RS09575	COG2010	Cytochrome c
HLB40_RS09590	COG3278	Belongs to the heme-copper respiratory oxidase family
HLB40_RS09600	COG0840	transmembrane signaling receptor activity
HLB40_RS09615	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HLB40_RS09620	COG0425	Belongs to the sulfur carrier protein TusA family
HLB40_RS09630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB40_RS09640	COG1132	(ABC) transporter
HLB40_RS09645	COG0741	lytic transglycosylase activity
HLB40_RS09650	COG0488	(ABC) transporter
HLB40_RS09655	COG0589	response to stress
HLB40_RS09665	COG1024	Enoyl-CoA hydratase
HLB40_RS09665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS09670	COG0183	Belongs to the thiolase family
HLB40_RS09715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HLB40_RS09720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB40_RS09730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLB40_RS09745	COG1477	protein flavinylation
HLB40_RS09750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB40_RS09755	COG0584	glycerophosphoryl diester phosphodiesterase
HLB40_RS09765	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLB40_RS09770	COG1136	(ABC) transporter
HLB40_RS09775	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLB40_RS09795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLB40_RS09795	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLB40_RS09805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB40_RS09810	COG2853	Lipoprotein
HLB40_RS09820	COG2204	response regulator
HLB40_RS09830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLB40_RS09835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB40_RS09840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLB40_RS09845	COG0583	DNA-binding transcription factor activity
HLB40_RS09855	COG4251	negative regulation of phosphorylation
HLB40_RS09855	COG3706	GGDEF domain
HLB40_RS09855	COG5001	Diguanylate cyclase
HLB40_RS09855	COG2203	Gaf domain
HLB40_RS09880	COG2233	PERMEase
HLB40_RS09910	COG0556	nucleotide-excision repair
HLB40_RS09915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLB40_RS09945	COG0596	Alpha beta hydrolase
HLB40_RS09955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB40_RS09970	COG2214	Heat shock protein DnaJ domain protein
HLB40_RS09975	COG0443	Heat shock 70 kDa protein
HLB40_RS09990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLB40_RS09995	COG0066	3-isopropylmalate dehydratase activity
HLB40_RS10000	COG0473	3-isopropylmalate dehydrogenase activity
HLB40_RS10030	COG0135	phosphoribosylanthranilate isomerase activity
HLB40_RS10035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLB40_RS10040	COG0285	dihydrofolate synthase activity
HLB40_RS10045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLB40_RS10050	COG1286	toxin biosynthetic process
HLB40_RS10085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS10110	COG3397	chitin binding
HLB40_RS10115	COG3469	chitinase activity
HLB40_RS10130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HLB40_RS10165	COG1129	ABC transporter
HLB40_RS10170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS10175	COG1609	Transcriptional regulator
HLB40_RS10180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB40_RS10185	COG1869	D-ribose catabolic process
HLB40_RS10210	COG1278	Cold shock
HLB40_RS10220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB40_RS10225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLB40_RS10230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLB40_RS10235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HLB40_RS10240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLB40_RS10245	COG0072	phenylalanine-tRNA ligase activity
HLB40_RS10250	COG0776	regulation of translation
HLB40_RS10285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB40_RS10320	COG1309	transcriptional regulator
HLB40_RS10325	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS10350	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS10355	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS10360	COG4191	Histidine kinase
HLB40_RS10365	COG4566	intracellular signal transduction
HLB40_RS10375	COG1598	PFAM Uncharacterised protein family UPF0150
HLB40_RS10400	COG1126	abc transporter atp-binding protein
HLB40_RS10450	COG0450	alkyl hydroperoxide reductase
HLB40_RS10480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS10490	COG1538	Outer membrane efflux protein
HLB40_RS10500	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB40_RS10505	COG3657	addiction module killer protein
HLB40_RS10510	COG5383	Protein conserved in bacteria
HLB40_RS10515	COG3706	GGDEF domain
HLB40_RS10540	COG0531	amino acid
HLB40_RS10550	COG0174	glutamine synthetase
HLB40_RS10555	COG1335	isochorismatase
HLB40_RS10565	COG0583	DNA-binding transcription factor activity
HLB40_RS10640	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HLB40_RS10645	COG0247	lactate metabolic process
HLB40_RS10650	COG0277	FAD linked oxidase domain protein
HLB40_RS10655	COG0277	FAD linked oxidase domain protein
HLB40_RS10660	COG2186	Transcriptional regulator
HLB40_RS10685	COG1063	alcohol dehydrogenase
HLB40_RS10705	COG0709	Synthesizes selenophosphate from selenide and ATP
HLB40_RS10710	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HLB40_RS10715	COG0701	Predicted permease
HLB40_RS10720	COG1414	Transcriptional regulator
HLB40_RS10725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS10730	COG0765	amino acid transport
HLB40_RS10735	COG1126	abc transporter atp-binding protein
HLB40_RS10740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS10750	COG0625	glutathione transferase activity
HLB40_RS10755	COG0384	phenazine biosynthesis protein PhzF
HLB40_RS10770	COG0248	Ppx GppA phosphatase
HLB40_RS10795	COG0019	diaminopimelate decarboxylase activity
HLB40_RS10810	COG0071	Belongs to the small heat shock protein (HSP20) family
HLB40_RS10815	COG0113	porphobilinogen synthase activity
HLB40_RS10845	COG4172	Belongs to the ABC transporter superfamily
HLB40_RS10850	COG4239	(ABC) transporter, permease
HLB40_RS10855	COG4174	ABC transporter (Permease)
HLB40_RS10860	COG4166	transmembrane transport
HLB40_RS10895	COG4650	regulator
HLB40_RS10910	COG1690	Belongs to the RtcB family
HLB40_RS10920	COG3541	Predicted nucleotidyltransferase
HLB40_RS10925	COG0430	RNA-3'-phosphate cyclase activity
HLB40_RS10950	COG0583	DNA-binding transcription factor activity
HLB40_RS10975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLB40_RS10980	COG0583	DNA-binding transcription factor activity
HLB40_RS10985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLB40_RS10995	COG3180	Ammonia monooxygenase
HLB40_RS11000	COG0583	DNA-binding transcription factor activity
HLB40_RS11010	COG3609	addiction module antidote protein, CC2985 family
HLB40_RS11015	COG1477	protein flavinylation
HLB40_RS11040	COG0517	IMP dehydrogenase activity
HLB40_RS11060	COG1177	transmembrane transport
HLB40_RS11065	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB40_RS11070	COG3842	ATPase activity
HLB40_RS11075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLB40_RS11080	COG0174	glutamine synthetase
HLB40_RS11085	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS11090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS11095	COG1396	sequence-specific DNA binding
HLB40_RS11095	COG1917	Cupin 2, conserved barrel domain protein
HLB40_RS11130	COG1595	DNA-templated transcription, initiation
HLB40_RS11135	COG3712	iron ion homeostasis
HLB40_RS11140	COG4772	TonB-dependent receptor
HLB40_RS11145	COG1944	ATP diphosphatase activity
HLB40_RS11210	COG2223	nitrite transmembrane transporter activity
HLB40_RS11235	COG0697	spore germination
HLB40_RS11240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS11255	COG0659	secondary active sulfate transmembrane transporter activity
HLB40_RS11265	COG1999	signal sequence binding
HLB40_RS11280	COG0583	DNA-binding transcription factor activity
HLB40_RS11285	COG3048	D-serine ammonia-lyase activity
HLB40_RS11290	COG2610	gluconate transmembrane transporter activity
HLB40_RS11295	COG0251	oxidation-reduction process
HLB40_RS11305	COG0688	phosphatidylethanolamine metabolic process
HLB40_RS11320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB40_RS11335	COG0346	lactoylglutathione lyase activity
HLB40_RS11345	COG0826	peptidase U32
HLB40_RS11360	COG2205	protein histidine kinase activity
HLB40_RS11360	COG0784	Response regulator, receiver
HLB40_RS11375	COG2197	response regulator
HLB40_RS11385	COG1538	Outer membrane efflux protein
HLB40_RS11395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS11455	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB40_RS11465	COG1611	Belongs to the LOG family
HLB40_RS11470	COG2204	response regulator
HLB40_RS11475	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HLB40_RS11485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB40_RS11505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS11510	COG0174	glutamine synthetase
HLB40_RS11525	COG1335	isochorismatase
HLB40_RS11535	COG0417	DNA replication proofreading
HLB40_RS11545	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HLB40_RS11550	COG0477	Major facilitator Superfamily
HLB40_RS11570	COG4319	ketosteroid isomerase
HLB40_RS11575	COG4335	DNA alkylation repair
HLB40_RS11585	COG0583	DNA-binding transcription factor activity
HLB40_RS11590	COG2828	Protein conserved in bacteria
HLB40_RS11595	COG1301	dicarboxylic acid transport
HLB40_RS11600	COG2851	Citrate transporter
HLB40_RS11615	COG1704	LemA family
HLB40_RS11620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLB40_RS11655	COG0596	Alpha beta hydrolase
HLB40_RS11670	COG0640	Transcriptional regulator
HLB40_RS11685	COG2308	Evidence 4 Homologs of previously reported genes of
HLB40_RS11695	COG1305	Transglutaminase-like
HLB40_RS11700	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLB40_RS11705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB40_RS11710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB40_RS11720	COG0022	dehydrogenase e1 component
HLB40_RS11725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB40_RS11730	COG1522	sequence-specific DNA binding
HLB40_RS11740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLB40_RS11770	COG1309	transcriptional regulator
HLB40_RS11780	COG0493	'glutamate synthase
HLB40_RS11790	COG1953	Uracil, thiamine, allantoin
HLB40_RS11800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS11805	COG0517	IMP dehydrogenase activity
HLB40_RS11805	COG4175	Glycine betaine
HLB40_RS11815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB40_RS11830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS11845	COG4804	nuclease activity
HLB40_RS11855	COG1595	DNA-templated transcription, initiation
HLB40_RS11865	COG1401	restriction endodeoxyribonuclease activity
HLB40_RS11910	COG2391	methyltransferase activity
HLB40_RS11985	COG0745	RESPONSE REGULATOR receiver
HLB40_RS12000	COG3383	formate dehydrogenase (NAD+) activity
HLB40_RS12005	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLB40_RS12010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS12040	COG3718	enzyme involved in inositol metabolism
HLB40_RS12055	COG3962	Belongs to the TPP enzyme family
HLB40_RS12060	COG0673	inositol 2-dehydrogenase activity
HLB40_RS12065	COG1082	Xylose isomerase domain protein TIM barrel
HLB40_RS12070	COG0673	inositol 2-dehydrogenase activity
HLB40_RS12080	COG1129	ABC transporter
HLB40_RS12085	COG4211	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS12130	COG4774	siderophore transport
HLB40_RS12145	COG1320	monovalent cation:proton antiporter activity
HLB40_RS12150	COG2212	antiporter activity
HLB40_RS12160	COG0651	ATP synthesis coupled electron transport
HLB40_RS12165	COG1006	Multisubunit Na H antiporter MnhC subunit
HLB40_RS12170	COG2111	Na H antiporter
HLB40_RS12170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB40_RS12240	COG0673	inositol 2-dehydrogenase activity
HLB40_RS12245	COG0515	serine threonine protein kinase
HLB40_RS12250	COG1073	alpha beta
HLB40_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS12270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB40_RS12275	COG1335	isochorismatase
HLB40_RS12290	COG3383	formate dehydrogenase (NAD+) activity
HLB40_RS12300	COG0814	amino acid
HLB40_RS12330	COG0589	response to stress
HLB40_RS12340	COG0745	RESPONSE REGULATOR receiver
HLB40_RS12345	COG2205	protein histidine kinase activity
HLB40_RS12360	COG3791	Glutathione-dependent formaldehyde-activating
HLB40_RS12375	COG0583	DNA-binding transcription factor activity
HLB40_RS12380	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HLB40_RS12385	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS12390	COG2079	MmgE PrpD family protein
HLB40_RS12440	COG0431	NADPH-dependent FMN reductase
HLB40_RS12500	COG2271	Major facilitator Superfamily
HLB40_RS12505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB40_RS12535	COG0583	DNA-binding transcription factor activity
HLB40_RS12545	COG1942	4-Oxalocrotonate Tautomerase
HLB40_RS12605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS12610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS12625	COG0596	Alpha beta hydrolase
HLB40_RS12630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLB40_RS12635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLB40_RS12635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLB40_RS12640	COG1609	Transcriptional regulator
HLB40_RS12645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB40_RS12655	COG2384	SAM-dependent methyltransferase
HLB40_RS12660	COG0789	Transcriptional regulator
HLB40_RS12665	COG1090	epimerase
HLB40_RS12680	COG3064	Membrane
HLB40_RS12735	COG2080	2 iron, 2 sulfur cluster binding
HLB40_RS12740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HLB40_RS12745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB40_RS12750	COG1280	lysine exporter protein (LysE YggA)
HLB40_RS12775	COG1566	PFAM secretion protein HlyD family protein
HLB40_RS12785	COG2828	Protein conserved in bacteria
HLB40_RS12790	COG2207	Transcriptional regulator
HLB40_RS12805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLB40_RS12845	COG2084	Dehydrogenase
HLB40_RS12850	COG3395	kinase activity
HLB40_RS12855	COG0235	Class ii aldolase
HLB40_RS12860	COG2610	gluconate transmembrane transporter activity
HLB40_RS12865	COG3622	Belongs to the hyi family
HLB40_RS12875	COG1349	DNA-binding transcription factor activity
HLB40_RS12935	COG1902	pentaerythritol trinitrate reductase activity
HLB40_RS12940	COG0300	oxidoreductase activity
HLB40_RS12945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB40_RS12945	COG0596	Alpha beta hydrolase
HLB40_RS12950	COG0604	alcohol dehydrogenase
HLB40_RS12950	COG3321	synthase
HLB40_RS12955	COG2200	EAL domain
HLB40_RS12955	COG2202	Pas domain
HLB40_RS12955	COG2199	diguanylate cyclase activity
HLB40_RS12960	COG0833	amino acid
HLB40_RS12965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS12970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLB40_RS12985	COG0494	nUDIX hydrolase
HLB40_RS12995	COG3220	belongs to the UPF0276 family
HLB40_RS13005	COG2259	Doxx family
HLB40_RS13015	COG2205	protein histidine kinase activity
HLB40_RS13060	COG1280	lysine exporter protein (LysE YggA)
HLB40_RS13075	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLB40_RS13095	COG0754	glutathionylspermidine amidase activity
HLB40_RS13105	COG3766	membrane
HLB40_RS13125	COG1842	Phage shock protein A
HLB40_RS13160	COG0583	DNA-binding transcription factor activity
HLB40_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS13190	COG4172	Belongs to the ABC transporter superfamily
HLB40_RS13195	COG4239	(ABC) transporter, permease
HLB40_RS13200	COG4174	ABC transporter (Permease)
HLB40_RS13205	COG4166	transmembrane transport
HLB40_RS13210	COG4166	transmembrane transport
HLB40_RS13215	COG1388	LysM domain
HLB40_RS13215	COG0741	lytic transglycosylase activity
HLB40_RS13220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB40_RS13230	COG0328	RNA-DNA hybrid ribonuclease activity
HLB40_RS13245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLB40_RS13270	COG0431	NADPH-dependent FMN reductase
HLB40_RS13275	COG0640	Transcriptional regulator
HLB40_RS13290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLB40_RS13295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB40_RS13305	COG3139	Protein of unknown function (DUF1315)
HLB40_RS13315	COG0308	aminopeptidase N
HLB40_RS13320	COG0659	secondary active sulfate transmembrane transporter activity
HLB40_RS13340	COG2706	6-phosphogluconolactonase activity
HLB40_RS13370	COG0420	3'-5' exonuclease activity
HLB40_RS13375	COG2207	Transcriptional regulator
HLB40_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS13400	COG4221	oxidoreductase activity
HLB40_RS13435	COG0714	Associated with various cellular activities
HLB40_RS13440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS13445	COG0477	Major facilitator Superfamily
HLB40_RS13450	COG0579	oxidoreductase
HLB40_RS13455	COG2186	Transcriptional regulator
HLB40_RS13485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB40_RS13490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLB40_RS13650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB40_RS13665	COG1794	racemase activity, acting on amino acids and derivatives
HLB40_RS13695	COG3278	Belongs to the heme-copper respiratory oxidase family
HLB40_RS13700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB40_RS13735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS13740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS13745	COG1538	Outer membrane efflux protein
HLB40_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS13760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS13765	COG0348	domain, Protein
HLB40_RS13775	COG1285	pathogenesis
HLB40_RS13795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLB40_RS13810	COG3568	Endonuclease Exonuclease Phosphatase
HLB40_RS13860	COG1640	4-alpha-glucanotransferase
HLB40_RS13865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLB40_RS13870	COG0297	glycogen (starch) synthase activity
HLB40_RS13875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB40_RS13885	COG1238	metal cluster binding
HLB40_RS13925	COG0667	Aldo Keto reductase
HLB40_RS13930	COG0583	DNA-binding transcription factor activity
HLB40_RS13945	COG2366	antibiotic biosynthetic process
HLB40_RS13985	COG0583	DNA-binding transcription factor activity
HLB40_RS13995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB40_RS13995	COG1017	nitric oxide dioxygenase activity
HLB40_RS14000	COG0583	DNA-binding transcription factor activity
HLB40_RS14005	COG2066	Belongs to the glutaminase family
HLB40_RS14015	COG2233	PERMEase
HLB40_RS14030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLB40_RS14065	COG2194	sulfuric ester hydrolase activity
HLB40_RS14075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLB40_RS14080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLB40_RS14085	COG0561	phosphatase activity
HLB40_RS14090	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLB40_RS14095	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS14095	COG2030	dehydratase
HLB40_RS14110	COG3162	membrane
HLB40_RS14115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB40_RS14120	COG2151	metal-sulfur cluster biosynthetic enzyme
HLB40_RS14125	COG3396	Phenylacetate-CoA oxygenase
HLB40_RS14130	COG3460	Phenylacetate-CoA oxygenase
HLB40_RS14135	COG3396	Phenylacetate-CoA oxygenase
HLB40_RS14145	COG0183	Belongs to the thiolase family
HLB40_RS14150	COG2050	protein possibly involved in aromatic compounds catabolism
HLB40_RS14155	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS14160	COG1024	Enoyl-CoA hydratase
HLB40_RS14165	COG1024	Enoyl-CoA hydratase
HLB40_RS14175	COG3327	negative regulation of DNA-templated transcription, initiation
HLB40_RS14195	COG2204	response regulator
HLB40_RS14240	COG0840	transmembrane signaling receptor activity
HLB40_RS14245	COG1968	undecaprenyl-diphosphatase activity
HLB40_RS14265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLB40_RS14280	COG0488	(ABC) transporter
HLB40_RS14295	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HLB40_RS14305	COG2133	pyrroloquinoline quinone binding
HLB40_RS14315	COG0189	ligase activity
HLB40_RS14320	COG0598	Magnesium transport protein CorA
HLB40_RS14325	COG0024	Methionine aminopeptidase
HLB40_RS14340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLB40_RS14345	COG4574	serine-type endopeptidase inhibitor activity
HLB40_RS14420	COG0726	polysaccharide deacetylase
HLB40_RS14490	COG1070	Carbohydrate kinase
HLB40_RS14510	COG1175	transmembrane transport
HLB40_RS14520	COG4774	siderophore transport
HLB40_RS14525	COG2207	Transcriptional regulator
HLB40_RS14530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB40_RS14540	COG0183	Belongs to the thiolase family
HLB40_RS14545	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS14550	COG1024	Enoyl-CoA hydratase
HLB40_RS14555	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS14560	COG1024	Enoyl-CoA hydratase
HLB40_RS14575	COG2814	Major facilitator Superfamily
HLB40_RS14605	COG0765	amino acid transport
HLB40_RS14610	COG0165	Argininosuccinate lyase
HLB40_RS14635	COG2076	Multidrug Resistance protein
HLB40_RS14640	COG2076	Multidrug Resistance protein
HLB40_RS14645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HLB40_RS14650	COG0726	polysaccharide deacetylase
HLB40_RS14655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS14655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB40_RS14660	COG0463	Glycosyl transferase, family 2
HLB40_RS14665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLB40_RS14680	COG1131	(ABC) transporter
HLB40_RS14725	COG4638	Rieske (2fe-2S)
HLB40_RS14730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB40_RS14750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLB40_RS14755	COG0142	geranyltranstransferase activity
HLB40_RS14760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLB40_RS14775	COG0765	amino acid transport
HLB40_RS14785	COG0405	Gamma-glutamyltransferase
HLB40_RS14800	COG0667	Aldo Keto reductase
HLB40_RS14825	COG0500	methyltransferase
HLB40_RS14835	COG4555	ABC transporter
HLB40_RS14875	COG1063	alcohol dehydrogenase
HLB40_RS14890	COG0589	response to stress
HLB40_RS14910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB40_RS14915	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HLB40_RS14920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB40_RS14940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLB40_RS14950	COG0459	protein refolding
HLB40_RS14955	COG0589	response to stress
HLB40_RS14975	COG0071	Belongs to the small heat shock protein (HSP20) family
HLB40_RS14985	COG1022	Amp-dependent synthetase and ligase
HLB40_RS14995	COG4221	oxidoreductase activity
HLB40_RS15025	COG2217	Heavy metal translocating P-type atpase
HLB40_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS15115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS15120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS15140	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS15140	COG1024	Enoyl-CoA hydratase
HLB40_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS15175	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS15185	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS15190	COG0300	oxidoreductase activity
HLB40_RS15190	COG4221	oxidoreductase activity
HLB40_RS15190	COG3321	synthase
HLB40_RS15190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB40_RS15195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS15200	COG1231	oxidoreductase activity
HLB40_RS15215	COG2863	cytochrome
HLB40_RS15235	COG0251	oxidation-reduction process
HLB40_RS15245	COG0745	RESPONSE REGULATOR receiver
HLB40_RS15265	COG0702	epimerase
HLB40_RS15280	COG1335	isochorismatase
HLB40_RS15285	COG0583	DNA-binding transcription factor activity
HLB40_RS15305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HLB40_RS15340	COG1116	anion transmembrane transporter activity
HLB40_RS15345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS15350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS15355	COG0235	Class ii aldolase
HLB40_RS15360	COG0583	DNA-binding transcription factor activity
HLB40_RS15380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS15390	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS15415	COG4206	TonB-dependent receptor
HLB40_RS15435	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS15440	COG0583	DNA-binding transcription factor activity
HLB40_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS15455	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HLB40_RS15495	COG3264	Mechanosensitive ion channel
HLB40_RS15495	COG1511	domain protein
HLB40_RS15500	COG3706	GGDEF domain
HLB40_RS15505	COG0583	DNA-binding transcription factor activity
HLB40_RS15510	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS15555	COG0247	lactate metabolic process
HLB40_RS15555	COG0277	FAD linked oxidase domain protein
HLB40_RS15560	COG0583	DNA-binding transcription factor activity
HLB40_RS15575	COG4104	PAAR repeat-containing protein
HLB40_RS15610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB40_RS15610	COG2146	nitrite reductase [NAD(P)H] activity
HLB40_RS15615	COG2146	nitrite reductase [NAD(P)H] activity
HLB40_RS15615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB40_RS15620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLB40_RS15630	COG1120	ATPase activity
HLB40_RS15635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB40_RS15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB40_RS15645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB40_RS15650	COG4264	IucA IucC family
HLB40_RS15660	COG4264	IucA IucC family
HLB40_RS15665	COG2814	Major facilitator Superfamily
HLB40_RS15670	COG0019	diaminopimelate decarboxylase activity
HLB40_RS15675	COG4264	IucA IucC family
HLB40_RS15680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB40_RS15685	COG4774	siderophore transport
HLB40_RS15690	COG3712	iron ion homeostasis
HLB40_RS15695	COG1595	DNA-templated transcription, initiation
HLB40_RS15715	COG0174	glutamine synthetase
HLB40_RS15725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS15735	COG2200	EAL domain
HLB40_RS15760	COG0784	Response regulator, receiver
HLB40_RS15760	COG2205	protein histidine kinase activity
HLB40_RS15790	COG1522	sequence-specific DNA binding
HLB40_RS15800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB40_RS15810	COG0473	3-isopropylmalate dehydrogenase activity
HLB40_RS15845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB40_RS15850	COG0601	transmembrane transport
HLB40_RS15855	COG0747	negative chemotaxis
HLB40_RS15860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS15870	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS15900	COG0589	response to stress
HLB40_RS15905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS15910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS15915	COG1116	anion transmembrane transporter activity
HLB40_RS15930	COG4977	sequence-specific DNA binding
HLB40_RS15930	COG1917	Cupin 2, conserved barrel domain protein
HLB40_RS15935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS15945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS15950	COG1116	anion transmembrane transporter activity
HLB40_RS15980	COG0656	L-ascorbic acid biosynthetic process
HLB40_RS15985	COG2205	protein histidine kinase activity
HLB40_RS15985	COG0784	Response regulator, receiver
HLB40_RS15990	COG3300	MHYT domain
HLB40_RS15990	COG5001	Diguanylate cyclase
HLB40_RS16000	COG2197	response regulator
HLB40_RS16020	COG0513	Belongs to the DEAD box helicase family
HLB40_RS16040	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HLB40_RS16045	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HLB40_RS16090	COG1113	amino acid transport
HLB40_RS16110	COG0531	amino acid
HLB40_RS16125	COG2909	trisaccharide binding
HLB40_RS16135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLB40_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS16160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS16175	COG0210	DNA helicase
HLB40_RS16190	COG0604	alcohol dehydrogenase
HLB40_RS16190	COG3321	synthase
HLB40_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS16230	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS16245	COG3469	chitinase activity
HLB40_RS16250	COG3397	chitin binding
HLB40_RS16255	COG0583	DNA-binding transcription factor activity
HLB40_RS16275	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS16295	COG2072	flavoprotein involved in K transport
HLB40_RS16300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS16305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS16310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS16325	COG1566	PFAM secretion protein HlyD family protein
HLB40_RS16350	COG2205	protein histidine kinase activity
HLB40_RS16350	COG2198	Histidine kinase
HLB40_RS16350	COG0784	Response regulator, receiver
HLB40_RS16360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB40_RS16365	COG2205	protein histidine kinase activity
HLB40_RS16365	COG3437	response regulator, receiver
HLB40_RS16365	COG3850	Histidine kinase
HLB40_RS16365	COG4999	Histidine kinase
HLB40_RS16385	COG0672	)-iron permease
HLB40_RS16390	COG2822	iron ion transport
HLB40_RS16410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB40_RS16425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS16440	COG2816	NAD+ diphosphatase activity
HLB40_RS16445	COG1024	Enoyl-CoA hydratase
HLB40_RS16460	COG1335	isochorismatase
HLB40_RS16465	COG2205	protein histidine kinase activity
HLB40_RS16470	COG0745	RESPONSE REGULATOR receiver
HLB40_RS16475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS16510	COG1609	Transcriptional regulator
HLB40_RS16520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB40_RS16585	COG2814	Major facilitator Superfamily
HLB40_RS16590	COG1063	alcohol dehydrogenase
HLB40_RS16630	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS16635	COG3384	dioxygenase
HLB40_RS16645	COG2271	Major facilitator Superfamily
HLB40_RS16650	COG3971	2-oxopent-4-enoate hydratase activity
HLB40_RS16660	COG1929	Belongs to the glycerate kinase type-1 family
HLB40_RS16665	COG3835	regulator
HLB40_RS16670	COG2271	Major facilitator Superfamily
HLB40_RS16675	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS16685	COG0583	DNA-binding transcription factor activity
HLB40_RS16690	COG0667	Aldo Keto reductase
HLB40_RS16700	COG1846	Transcriptional regulator
HLB40_RS16710	COG0697	spore germination
HLB40_RS16715	COG0583	DNA-binding transcription factor activity
HLB40_RS16720	COG2200	EAL domain
HLB40_RS16785	COG3258	Cytochrome c
HLB40_RS16790	COG2863	cytochrome
HLB40_RS16815	COG3145	DNA-N1-methyladenine dioxygenase activity
HLB40_RS16820	COG2169	Transcriptional regulator
HLB40_RS16820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB40_RS16830	COG0604	alcohol dehydrogenase
HLB40_RS16850	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLB40_RS16855	COG0488	(ABC) transporter
HLB40_RS16865	COG0393	Putative heavy-metal-binding
HLB40_RS16965	COG3121	Chaperone
HLB40_RS16990	COG0583	DNA-binding transcription factor activity
HLB40_RS16995	COG0583	DNA-binding transcription factor activity
HLB40_RS17000	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB40_RS17005	COG0300	oxidoreductase activity
HLB40_RS17015	COG0583	DNA-binding transcription factor activity
HLB40_RS17020	COG1309	transcriptional regulator
HLB40_RS17045	COG0475	glutathione-regulated potassium exporter activity
HLB40_RS17050	COG1024	Enoyl-CoA hydratase
HLB40_RS17065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS17070	COG0789	Transcriptional regulator
HLB40_RS17100	COG2181	nitrate reductase activity
HLB40_RS17105	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLB40_RS17110	COG1140	nitrate reductase beta subunit
HLB40_RS17115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLB40_RS17120	COG2223	nitrite transmembrane transporter activity
HLB40_RS17130	COG3850	Histidine kinase
HLB40_RS17135	COG2197	response regulator
HLB40_RS17145	COG3154	lipid carrier protein
HLB40_RS17150	COG0826	peptidase U32
HLB40_RS17155	COG0826	peptidase U32
HLB40_RS17160	COG0303	'Molybdopterin
HLB40_RS17165	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLB40_RS17175	COG3604	Transcriptional regulator
HLB40_RS17180	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HLB40_RS17195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB40_RS17210	COG3256	nitric oxide reductase
HLB40_RS17215	COG2010	Cytochrome c
HLB40_RS17225	COG1845	cytochrome c oxidase, subunit III
HLB40_RS17230	COG0714	Associated with various cellular activities
HLB40_RS17245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HLB40_RS17250	COG0315	cyclic pyranopterin monophosphate synthase activity
HLB40_RS17270	COG3712	iron ion homeostasis
HLB40_RS17275	COG1595	DNA-templated transcription, initiation
HLB40_RS17315	COG0583	DNA-binding transcription factor activity
HLB40_RS17320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS17335	COG0861	Integral membrane protein TerC family
HLB40_RS17370	COG2207	Transcriptional regulator
HLB40_RS17390	COG2207	Transcriptional regulator
HLB40_RS17395	COG1064	alcohol dehydrogenase
HLB40_RS17415	COG1733	regulation of RNA biosynthetic process
HLB40_RS17440	COG1022	Amp-dependent synthetase and ligase
HLB40_RS17445	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS17450	COG1024	Enoyl-CoA hydratase
HLB40_RS17465	COG2814	Major facilitator Superfamily
HLB40_RS17480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB40_RS17485	COG0475	glutathione-regulated potassium exporter activity
HLB40_RS17515	COG0577	efflux transmembrane transporter activity
HLB40_RS17515	COG1136	(ABC) transporter
HLB40_RS17520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS17585	COG2197	response regulator
HLB40_RS17605	COG2186	Transcriptional regulator
HLB40_RS17615	COG0765	amino acid transport
HLB40_RS17630	COG3938	Belongs to the proline racemase family
HLB40_RS17635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS17650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS17665	COG3622	Belongs to the hyi family
HLB40_RS17680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLB40_RS17695	COG2815	serine threonine protein kinase
HLB40_RS17695	COG0515	serine threonine protein kinase
HLB40_RS17820	COG0583	DNA-binding transcription factor activity
HLB40_RS17825	COG1335	isochorismatase
HLB40_RS17830	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HLB40_RS17850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLB40_RS17885	COG1741	Belongs to the pirin family
HLB40_RS17910	COG1335	isochorismatase
HLB40_RS17930	COG2814	Major facilitator Superfamily
HLB40_RS17935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB40_RS17935	COG2010	Cytochrome c
HLB40_RS17940	COG2080	2 iron, 2 sulfur cluster binding
HLB40_RS17945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB40_RS17945	COG2010	Cytochrome c
HLB40_RS17955	COG1902	pentaerythritol trinitrate reductase activity
HLB40_RS17960	COG2205	protein histidine kinase activity
HLB40_RS17960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS17965	COG1301	dicarboxylic acid transport
HLB40_RS17975	COG2207	Transcriptional regulator
HLB40_RS17980	COG0300	oxidoreductase activity
HLB40_RS18005	COG0322	excinuclease ABC activity
HLB40_RS18010	COG2197	response regulator
HLB40_RS18030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLB40_RS18035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLB40_RS18040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB40_RS18045	COG4166	transmembrane transport
HLB40_RS18050	COG4174	ABC transporter (Permease)
HLB40_RS18055	COG4239	(ABC) transporter, permease
HLB40_RS18060	COG4172	Belongs to the ABC transporter superfamily
HLB40_RS18065	COG3604	Transcriptional regulator
HLB40_RS18070	COG2610	gluconate transmembrane transporter activity
HLB40_RS18075	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS18080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB40_RS18090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB40_RS18135	COG1607	acyl-coa hydrolase
HLB40_RS18140	COG0069	glutamate synthase activity
HLB40_RS18165	COG2203	Gaf domain
HLB40_RS18165	COG2199	diguanylate cyclase activity
HLB40_RS18175	COG0583	DNA-binding transcription factor activity
HLB40_RS18185	COG1538	Outer membrane efflux protein
HLB40_RS18205	COG2274	protein secretion by the type I secretion system
HLB40_RS18210	COG1253	flavin adenine dinucleotide binding
HLB40_RS18215	COG2390	Transcriptional regulator
HLB40_RS18220	COG0698	ribose 5-phosphate isomerase
HLB40_RS18225	COG1129	ABC transporter
HLB40_RS18230	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS18235	COG1879	ABC-type sugar transport system periplasmic component
HLB40_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS18245	COG1063	alcohol dehydrogenase
HLB40_RS18250	COG2376	Dihydroxyacetone kinase
HLB40_RS18290	COG0583	DNA-binding transcription factor activity
HLB40_RS18350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLB40_RS18350	COG0316	Belongs to the HesB IscA family
HLB40_RS18385	COG0616	signal peptide processing
HLB40_RS18400	COG4172	Belongs to the ABC transporter superfamily
HLB40_RS18405	COG4239	(ABC) transporter, permease
HLB40_RS18410	COG4174	ABC transporter (Permease)
HLB40_RS18415	COG4166	transmembrane transport
HLB40_RS18420	COG4206	TonB-dependent receptor
HLB40_RS18425	COG4206	TonB-dependent receptor
HLB40_RS18435	COG1595	DNA-templated transcription, initiation
HLB40_RS18440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS18440	COG1024	Enoyl-CoA hydratase
HLB40_RS18465	COG3189	MarR family transcriptional regulator
HLB40_RS18470	COG2186	Transcriptional regulator
HLB40_RS18545	COG4191	Histidine kinase
HLB40_RS18545	COG0784	Response regulator, receiver
HLB40_RS18565	COG0587	DNA-directed DNA polymerase activity
HLB40_RS18580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLB40_RS18600	COG2194	sulfuric ester hydrolase activity
HLB40_RS18605	COG0673	inositol 2-dehydrogenase activity
HLB40_RS18640	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS18650	COG0303	'Molybdopterin
HLB40_RS18655	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLB40_RS18660	COG0746	molybdenum cofactor guanylyltransferase activity
HLB40_RS18665	COG0583	DNA-binding transcription factor activity
HLB40_RS18680	COG0315	cyclic pyranopterin monophosphate synthase activity
HLB40_RS18685	COG3781	membrane
HLB40_RS18690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB40_RS18700	COG1271	oxidase subunit
HLB40_RS18705	COG1294	oxidase, subunit
HLB40_RS18725	COG0697	spore germination
HLB40_RS18730	COG1522	sequence-specific DNA binding
HLB40_RS18785	COG2989	Protein conserved in bacteria
HLB40_RS18800	COG5001	Diguanylate cyclase
HLB40_RS18800	COG3300	MHYT domain
HLB40_RS18810	COG1858	cytochrome C peroxidase
HLB40_RS18835	COG0579	oxidoreductase
HLB40_RS18880	COG2920	part of a sulfur-relay system
HLB40_RS18885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLB40_RS18890	COG0435	Glutathione S-transferase
HLB40_RS18895	COG1648	precorrin-2 dehydrogenase activity
HLB40_RS18895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLB40_RS18900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLB40_RS18905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLB40_RS18910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLB40_RS18915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLB40_RS18920	COG1674	ftsk spoiiie
HLB40_RS18925	COG0492	ferredoxin-NADP+ reductase activity
HLB40_RS18930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLB40_RS18935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HLB40_RS18940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLB40_RS18945	COG0542	response to heat
HLB40_RS18950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLB40_RS18955	COG1278	Cold shock
HLB40_RS18975	COG0482	sulfurtransferase activity
HLB40_RS18980	COG2915	High frequency lysogenization protein hflD homolog
HLB40_RS18990	COG2850	peptidyl-arginine hydroxylation
HLB40_RS18995	COG2153	protein acetylation
HLB40_RS19010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB40_RS19015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB40_RS19020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB40_RS19020	COG0649	NAD binding
HLB40_RS19035	COG1034	ATP synthesis coupled electron transport
HLB40_RS19040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HLB40_RS19045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB40_RS19055	COG0713	ATP synthesis coupled electron transport
HLB40_RS19070	COG1007	ATP synthesis coupled electron transport
HLB40_RS19080	COG2944	sequence-specific DNA binding
HLB40_RS19095	COG0395	ABC-type sugar transport system, permease component
HLB40_RS19105	COG3842	ATPase activity
HLB40_RS19110	COG3842	ATPase activity
HLB40_RS19115	COG3284	Transcriptional regulator
HLB40_RS19120	COG0215	cysteine-tRNA ligase activity
HLB40_RS19125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLB40_RS19135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLB40_RS19140	COG2814	Major facilitator Superfamily
HLB40_RS19145	COG1566	PFAM secretion protein HlyD family protein
HLB40_RS19155	COG1846	Transcriptional regulator
HLB40_RS19160	COG2911	Protein conserved in bacteria
HLB40_RS19165	COG0729	surface antigen
HLB40_RS19175	COG0708	Exodeoxyribonuclease III
HLB40_RS19185	COG2885	chlorophyll binding
HLB40_RS19190	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS19200	COG0789	Transcriptional regulator
HLB40_RS19210	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS19215	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS19220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLB40_RS19235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLB40_RS19245	COG2866	Carboxypeptidase
HLB40_RS19255	COG2814	Major facilitator Superfamily
HLB40_RS19260	COG3038	cytochrome b561
HLB40_RS19315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLB40_RS19325	COG0217	transcriptional regulatory protein
HLB40_RS19330	COG0583	DNA-binding transcription factor activity
HLB40_RS19335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB40_RS19340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB40_RS19345	COG3038	cytochrome b561
HLB40_RS19355	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLB40_RS19355	COG1902	pentaerythritol trinitrate reductase activity
HLB40_RS19385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB40_RS19390	COG0776	regulation of translation
HLB40_RS19395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLB40_RS19400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLB40_RS19405	COG0740	serine-type endopeptidase activity
HLB40_RS19410	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLB40_RS19430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLB40_RS19435	COG1686	Belongs to the peptidase S11 family
HLB40_RS19450	COG1253	flavin adenine dinucleotide binding
HLB40_RS19460	COG0583	DNA-binding transcription factor activity
HLB40_RS19470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HLB40_RS19480	COG3132	Protein of unknown function, DUF480
HLB40_RS19490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLB40_RS19510	COG0628	permease
HLB40_RS19515	COG0826	peptidase U32
HLB40_RS19525	COG2056	Na+-H+ antiporter family
HLB40_RS19530	COG0840	transmembrane signaling receptor activity
HLB40_RS19560	COG0720	synthase
HLB40_RS19570	COG0596	Alpha beta hydrolase
HLB40_RS19580	COG1051	belongs to the nudix hydrolase family
HLB40_RS19595	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLB40_RS19600	COG0402	S-adenosylhomocysteine deaminase activity
HLB40_RS19605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLB40_RS19620	COG1725	Transcriptional regulator
HLB40_RS19625	COG2207	Transcriptional regulator
HLB40_RS19640	COG0583	DNA-binding transcription factor activity
HLB40_RS19645	COG0583	DNA-binding transcription factor activity
HLB40_RS19655	COG1522	sequence-specific DNA binding
HLB40_RS19665	COG2223	nitrite transmembrane transporter activity
HLB40_RS19670	COG4772	TonB-dependent receptor
HLB40_RS19680	COG1595	DNA-templated transcription, initiation
HLB40_RS19725	COG3210	domain, Protein
HLB40_RS19755	COG2274	protein secretion by the type I secretion system
HLB40_RS19760	COG1538	Outer membrane efflux protein
HLB40_RS19765	COG2080	2 iron, 2 sulfur cluster binding
HLB40_RS19770	COG2010	Cytochrome c
HLB40_RS19770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB40_RS19775	COG2010	Cytochrome c
HLB40_RS19775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB40_RS19795	COG0840	transmembrane signaling receptor activity
HLB40_RS19800	COG4774	siderophore transport
HLB40_RS19805	COG0583	DNA-binding transcription factor activity
HLB40_RS19815	COG3591	Belongs to the peptidase S1B family
HLB40_RS19815	COG1864	DNA RNA non-specific endonuclease
HLB40_RS19835	COG4106	trans-aconitate 2-methyltransferase activity
HLB40_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS19855	COG1942	4-Oxalocrotonate Tautomerase
HLB40_RS19865	COG5507	3-demethylubiquinone-9 3-methyltransferase
HLB40_RS19880	COG3135	benzoate transporter
HLB40_RS19885	COG2814	Major facilitator Superfamily
HLB40_RS19915	COG3485	protocatechuate 3,4-dioxygenase
HLB40_RS19920	COG4829	muconolactone delta-isomerase
HLB40_RS19925	COG4948	Mandelate Racemase Muconate Lactonizing
HLB40_RS19955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLB40_RS19995	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HLB40_RS20015	COG2814	Major facilitator Superfamily
HLB40_RS20045	COG0154	amidase activity
HLB40_RS20070	COG0583	DNA-binding transcription factor activity
HLB40_RS20095	COG3318	Belongs to the UPF0149 family
HLB40_RS20095	COG3012	SEC-C Motif Domain Protein
HLB40_RS20110	COG0730	response to heat
HLB40_RS20125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB40_RS20135	COG1335	isochorismatase
HLB40_RS20140	COG1335	isochorismatase
HLB40_RS20150	COG0583	DNA-binding transcription factor activity
HLB40_RS20160	COG0656	L-ascorbic acid biosynthetic process
HLB40_RS20195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS20200	COG0577	efflux transmembrane transporter activity
HLB40_RS20200	COG1136	(ABC) transporter
HLB40_RS20205	COG1538	Outer membrane efflux protein
HLB40_RS20265	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HLB40_RS20275	COG1309	transcriptional regulator
HLB40_RS20285	COG0596	Alpha beta hydrolase
HLB40_RS20290	COG4977	sequence-specific DNA binding
HLB40_RS20300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB40_RS20305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB40_RS20380	COG0840	transmembrane signaling receptor activity
HLB40_RS20410	COG1132	(ABC) transporter
HLB40_RS20430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HLB40_RS20465	COG0477	Major facilitator Superfamily
HLB40_RS20470	COG0583	DNA-binding transcription factor activity
HLB40_RS20475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB40_RS20480	COG0235	Class ii aldolase
HLB40_RS20485	COG0477	Major facilitator Superfamily
HLB40_RS20490	COG0583	DNA-binding transcription factor activity
HLB40_RS20495	COG0768	penicillin binding
HLB40_RS20505	COG1063	alcohol dehydrogenase
HLB40_RS20535	COG5006	permease, DMT superfamily
HLB40_RS20545	COG1309	transcriptional regulator
HLB40_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS20575	COG0431	NADPH-dependent FMN reductase
HLB40_RS20580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS20590	COG3829	transcription factor binding
HLB40_RS20635	COG1121	(ABC) transporter
HLB40_RS20640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB40_RS20650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB40_RS20665	COG0642	Histidine kinase
HLB40_RS20675	COG4232	protein-disulfide reductase activity
HLB40_RS20680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB40_RS20705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB40_RS20730	COG1309	transcriptional regulator
HLB40_RS20745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLB40_RS20750	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS20770	COG3123	guanosine phosphorylase activity
HLB40_RS20775	COG0633	Ferredoxin
HLB40_RS20775	COG3217	Mosc domain protein beta barrel domain protein
HLB40_RS20790	COG3851	Histidine kinase
HLB40_RS20795	COG2197	response regulator
HLB40_RS20800	COG1597	lipid kinase activity
HLB40_RS20815	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLB40_RS20820	COG0746	molybdenum cofactor guanylyltransferase activity
HLB40_RS20830	COG0564	pseudouridine synthase activity
HLB40_RS20855	COG0004	ammonium transporteR
HLB40_RS20875	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLB40_RS20895	COG2197	response regulator
HLB40_RS20900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS20900	COG2205	protein histidine kinase activity
HLB40_RS20905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLB40_RS20910	COG1956	GAF domain-containing protein
HLB40_RS20920	COG2205	protein histidine kinase activity
HLB40_RS20920	COG0784	Response regulator, receiver
HLB40_RS20920	COG5002	protein histidine kinase activity
HLB40_RS20925	COG1846	Transcriptional regulator
HLB40_RS20930	COG0386	Belongs to the glutathione peroxidase family
HLB40_RS20935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB40_RS20940	COG0436	Aminotransferase
HLB40_RS20945	COG0501	Belongs to the peptidase M48B family
HLB40_RS20950	COG0500	methyltransferase
HLB40_RS20955	COG3384	dioxygenase
HLB40_RS20970	COG1024	Enoyl-CoA hydratase
HLB40_RS20980	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HLB40_RS20985	COG3214	Protein conserved in bacteria
HLB40_RS20995	COG0583	DNA-binding transcription factor activity
HLB40_RS21005	COG0583	DNA-binding transcription factor activity
HLB40_RS21010	COG1846	Transcriptional regulator
HLB40_RS21015	COG1764	response to oxidative stress
HLB40_RS21025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLB40_RS21040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLB40_RS21060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB40_RS21090	COG1376	ErfK ybiS ycfS ynhG family protein
HLB40_RS21105	COG4181	ATPase activity
HLB40_RS21110	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLB40_RS21115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLB40_RS21130	COG2197	response regulator
HLB40_RS21140	COG2259	Doxx family
HLB40_RS21145	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HLB40_RS21150	COG0084	hydrolase, TatD family'
HLB40_RS21185	COG0745	RESPONSE REGULATOR receiver
HLB40_RS21190	COG2205	protein histidine kinase activity
HLB40_RS21195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HLB40_RS21205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HLB40_RS21240	COG4221	oxidoreductase activity
HLB40_RS21255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB40_RS21265	COG2076	Multidrug Resistance protein
HLB40_RS21280	COG0529	Catalyzes the synthesis of activated sulfate
HLB40_RS21285	COG3754	Rhamnan synthesis protein F
HLB40_RS21315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLB40_RS21335	COG0776	regulation of translation
HLB40_RS21350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLB40_RS21355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLB40_RS21360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLB40_RS21370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HLB40_RS21380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HLB40_RS21385	COG0402	S-adenosylhomocysteine deaminase activity
HLB40_RS21390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB40_RS21395	COG0546	phosphoglycolate phosphatase activity
HLB40_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS21415	COG5001	Diguanylate cyclase
HLB40_RS21415	COG5002	protein histidine kinase activity
HLB40_RS21430	COG1054	Belongs to the UPF0176 family
HLB40_RS21435	COG0271	Belongs to the BolA IbaG family
HLB40_RS21445	COG0114	fumarate hydratase activity
HLB40_RS21450	COG0697	spore germination
HLB40_RS21455	COG0183	Belongs to the thiolase family
HLB40_RS21460	COG2326	polyphosphate kinase activity
HLB40_RS21465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLB40_RS21465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS21470	COG0367	asparagine synthase
HLB40_RS21475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLB40_RS21475	COG0189	ligase activity
HLB40_RS21480	COG1363	Peptidase, m42
HLB40_RS21485	COG3089	Belongs to the UPF0270 family
HLB40_RS21490	COG1742	UPF0060 membrane protein
HLB40_RS21505	COG1368	sulfuric ester hydrolase activity
HLB40_RS21525	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS21535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HLB40_RS21540	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HLB40_RS21545	COG0235	Class ii aldolase
HLB40_RS21555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLB40_RS21560	COG1073	alpha beta
HLB40_RS21585	COG2840	Smr protein MutS2
HLB40_RS21590	COG0302	gtp cyclohydrolase
HLB40_RS21600	COG0625	glutathione transferase activity
HLB40_RS21605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS21615	COG2252	PERMEase
HLB40_RS21640	COG4266	Belongs to the allantoicase family
HLB40_RS21645	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HLB40_RS21655	COG2233	PERMEase
HLB40_RS21680	COG1560	Kdo2-lipid A biosynthetic process
HLB40_RS21685	COG0850	regulation of cytokinetic process
HLB40_RS21690	COG2894	cell division
HLB40_RS21695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HLB40_RS21700	COG0564	pseudouridine synthase activity
HLB40_RS21710	COG1362	aminopeptidase activity
HLB40_RS21720	COG0668	transmembrane transport
HLB40_RS21725	COG1473	amidohydrolase
HLB40_RS21755	COG3842	ATPase activity
HLB40_RS21765	COG4221	oxidoreductase activity
HLB40_RS21765	COG3321	synthase
HLB40_RS21765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLB40_RS21765	COG0604	alcohol dehydrogenase
HLB40_RS21775	COG2200	EAL domain
HLB40_RS21800	COG0545	Peptidyl-prolyl cis-trans isomerase
HLB40_RS21805	COG2010	Cytochrome c
HLB40_RS21835	COG2974	May be involved in recombination
HLB40_RS21840	COG0385	Bile acid
HLB40_RS21845	COG2076	Multidrug Resistance protein
HLB40_RS21850	COG0477	Major facilitator Superfamily
HLB40_RS21875	COG2205	protein histidine kinase activity
HLB40_RS21875	COG2202	Pas domain
HLB40_RS21925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLB40_RS21930	COG0406	alpha-ribazole phosphatase activity
HLB40_RS21935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLB40_RS21945	COG1492	cobalamin metabolic process
HLB40_RS21960	COG0778	Nitroreductase
HLB40_RS21965	COG1797	cobyrinic acid a,c-diamide synthase activity
HLB40_RS21990	COG0791	NLP P60 protein
HLB40_RS21995	COG0791	NLP P60 protein
HLB40_RS22000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLB40_RS22005	COG0628	permease
HLB40_RS22015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLB40_RS22020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLB40_RS22035	COG3122	Protein conserved in bacteria
HLB40_RS22040	COG3956	TIGRFAM MazG family protein
HLB40_RS22045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLB40_RS22050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLB40_RS22070	COG5002	protein histidine kinase activity
HLB40_RS22070	COG2205	protein histidine kinase activity
HLB40_RS22070	COG0784	Response regulator, receiver
HLB40_RS22075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB40_RS22095	COG1393	Belongs to the ArsC family
HLB40_RS22115	COG0037	tRNA processing
HLB40_RS22125	COG3091	SprT-like family
HLB40_RS22130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLB40_RS22170	COG2205	protein histidine kinase activity
HLB40_RS22175	COG0745	RESPONSE REGULATOR receiver
HLB40_RS22185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLB40_RS22185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB40_RS22200	COG1558	bacterial-type flagellum-dependent cell motility
HLB40_RS22205	COG1815	bacterial-type flagellum-dependent cell motility
HLB40_RS22210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB40_RS22215	COG0784	Response regulator, receiver
HLB40_RS22215	COG0835	chemotaxis
HLB40_RS22235	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HLB40_RS22240	COG0477	Major facilitator Superfamily
HLB40_RS22250	COG2205	protein histidine kinase activity
HLB40_RS22280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS22315	COG2239	Acts as a magnesium transporter
HLB40_RS22335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HLB40_RS22340	COG0527	aspartate kinase activity
HLB40_RS22345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB40_RS22350	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HLB40_RS22355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLB40_RS22360	COG2988	succinylglutamate desuccinylase activity
HLB40_RS22370	COG3724	N-succinylarginine dihydrolase activity
HLB40_RS22375	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS22390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB40_RS22420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS22425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB40_RS22435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB40_RS22470	COG0563	adenylate kinase activity
HLB40_RS22485	COG3706	GGDEF domain
HLB40_RS22505	COG0504	CTP synthase activity
HLB40_RS22510	COG2329	Antibiotic biosynthesis monooxygenase
HLB40_RS22520	COG0584	glycerophosphoryl diester phosphodiesterase
HLB40_RS22550	COG0306	phosphate transporter
HLB40_RS22560	COG1984	allophanate hydrolase subunit 2
HLB40_RS22570	COG0439	Biotin carboxylase
HLB40_RS22580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HLB40_RS22595	COG3008	intermembrane lipid transfer
HLB40_RS22600	COG2995	paraquat-inducible protein a
HLB40_RS22605	COG2995	paraquat-inducible protein a
HLB40_RS22620	COG0583	DNA-binding transcription factor activity
HLB40_RS22625	COG4941	Belongs to the sigma-70 factor family
HLB40_RS22635	COG3795	YCII-related domain
HLB40_RS22680	COG0436	Aminotransferase
HLB40_RS22690	COG3265	gluconokinase activity
HLB40_RS22695	COG1609	Transcriptional regulator
HLB40_RS22705	COG0583	DNA-binding transcription factor activity
HLB40_RS22715	COG0625	glutathione transferase activity
HLB40_RS22720	COG2271	Major facilitator Superfamily
HLB40_RS22730	COG0583	DNA-binding transcription factor activity
HLB40_RS22750	COG0242	peptide deformylase activity
HLB40_RS22755	COG1295	ribonuclease BN
HLB40_RS22770	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS22775	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS22780	COG2267	carboxylic ester hydrolase activity
HLB40_RS22785	COG2030	dehydratase
HLB40_RS22810	COG3530	Putative quorum-sensing-regulated virulence factor
HLB40_RS22815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLB40_RS22820	COG0800	Aldolase
HLB40_RS22835	COG1737	Transcriptional regulator
HLB40_RS22840	COG0676	glucose-6-phosphate 1-epimerase activity
HLB40_RS22850	COG3842	ATPase activity
HLB40_RS22855	COG0395	ABC-type sugar transport system, permease component
HLB40_RS22860	COG1175	transmembrane transport
HLB40_RS22865	COG1653	transport
HLB40_RS22900	COG1803	Methylglyoxal synthase
HLB40_RS22910	COG3712	iron ion homeostasis
HLB40_RS22915	COG4771	TonB-dependent receptor
HLB40_RS22925	COG2832	Protein of unknown function (DUF454)
HLB40_RS22930	COG0840	transmembrane signaling receptor activity
HLB40_RS22935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLB40_RS22960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLB40_RS22980	COG0509	glycine decarboxylation via glycine cleavage system
HLB40_RS22985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLB40_RS22985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLB40_RS22990	COG1760	l-serine dehydratase
HLB40_RS23000	COG1278	Cold shock
HLB40_RS23010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLB40_RS23015	COG4964	Belongs to the GSP D family
HLB40_RS23105	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB40_RS23110	COG1129	ABC transporter
HLB40_RS23115	COG1879	ABC-type sugar transport system periplasmic component
HLB40_RS23125	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS23175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLB40_RS23180	COG0602	queuosine metabolic process
HLB40_RS23185	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HLB40_RS23190	COG2885	chlorophyll binding
HLB40_RS23195	COG0823	Involved in the tonB-independent uptake of proteins
HLB40_RS23215	COG0824	Thioesterase
HLB40_RS23220	COG2255	four-way junction helicase activity
HLB40_RS23225	COG0632	four-way junction helicase activity
HLB40_RS23230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HLB40_RS23235	COG0217	transcriptional regulatory protein
HLB40_RS23240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLB40_RS23250	COG0783	Belongs to the Dps family
HLB40_RS23260	COG2900	Belongs to the SlyX family
HLB40_RS23275	COG0668	transmembrane transport
HLB40_RS23280	COG1666	GTP binding
HLB40_RS23290	COG4191	Histidine kinase
HLB40_RS23290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS23295	COG2096	Adenosyltransferase
HLB40_RS23310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLB40_RS23315	COG0653	protein targeting
HLB40_RS23325	COG0433	COG0433 Predicted ATPase
HLB40_RS23335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLB40_RS23335	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS23365	COG2925	Exonuclease
HLB40_RS23440	COG1074	ATP-dependent DNA helicase activity
HLB40_RS23445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLB40_RS23455	COG0714	Associated with various cellular activities
HLB40_RS23475	COG0469	pyruvate kinase activity
HLB40_RS23480	COG1024	Enoyl-CoA hydratase
HLB40_RS23490	COG3706	GGDEF domain
HLB40_RS23500	COG4191	Histidine kinase
HLB40_RS23510	COG0477	Major facilitator Superfamily
HLB40_RS23535	COG2207	Transcriptional regulator
HLB40_RS23540	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS23550	COG0583	DNA-binding transcription factor activity
HLB40_RS23555	COG2910	NAD(P)H-binding
HLB40_RS23565	COG0583	DNA-binding transcription factor activity
HLB40_RS23585	COG0477	Major facilitator Superfamily
HLB40_RS23600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB40_RS23605	COG0583	DNA-binding transcription factor activity
HLB40_RS23620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLB40_RS23650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS23655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS23665	COG3642	lipopolysaccharide core region biosynthetic process
HLB40_RS23675	COG0642	Histidine kinase
HLB40_RS23690	COG0459	protein refolding
HLB40_RS23695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLB40_RS23700	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLB40_RS23710	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS23715	COG0489	protein tyrosine kinase activity
HLB40_RS23720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB40_RS23720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB40_RS23725	COG4657	Part of a membrane complex involved in electron transport
HLB40_RS23730	COG2878	Part of a membrane complex involved in electron transport
HLB40_RS23735	COG4658	electron transport chain
HLB40_RS23740	COG4659	FMN binding
HLB40_RS23745	COG4660	Part of a membrane complex involved in electron transport
HLB40_RS23750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLB40_RS23760	COG2197	response regulator
HLB40_RS23765	COG0137	argininosuccinate synthase activity
HLB40_RS23775	COG0418	dihydroorotase activity
HLB40_RS23780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLB40_RS23785	COG0450	alkyl hydroperoxide reductase
HLB40_RS23800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLB40_RS23805	COG3383	formate dehydrogenase (NAD+) activity
HLB40_RS23815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLB40_RS23820	COG3842	ATPase activity
HLB40_RS23825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLB40_RS23835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLB40_RS23855	COG0765	amino acid transport
HLB40_RS23860	COG0765	amino acid transport
HLB40_RS23865	COG1126	abc transporter atp-binding protein
HLB40_RS23895	COG2076	Multidrug Resistance protein
HLB40_RS23915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB40_RS23930	COG4191	Histidine kinase
HLB40_RS23940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB40_RS23945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLB40_RS23950	COG0583	DNA-binding transcription factor activity
HLB40_RS23955	COG0456	acetyltransferase
HLB40_RS23960	COG1280	lysine exporter protein (LysE YggA)
HLB40_RS23970	COG0254	rRNA binding
HLB40_RS23980	COG0069	glutamate synthase activity
HLB40_RS24005	COG2246	polysaccharide biosynthetic process
HLB40_RS24020	COG1113	amino acid transport
HLB40_RS24030	COG1695	Transcriptional regulator
HLB40_RS24035	COG2375	cellular response to nickel ion
HLB40_RS24045	COG4628	conserved protein (DUF2132)
HLB40_RS24050	COG4206	TonB-dependent receptor
HLB40_RS24085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLB40_RS24100	COG2226	methyltransferase
HLB40_RS24105	COG0500	methyltransferase
HLB40_RS24110	COG0590	tRNA wobble adenosine to inosine editing
HLB40_RS24125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLB40_RS24125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB40_RS24135	COG0366	Alpha amylase catalytic
HLB40_RS24140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB40_RS24140	COG1263	PTS System
HLB40_RS24145	COG2188	Transcriptional regulator
HLB40_RS24160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLB40_RS24160	COG0519	Catalyzes the synthesis of GMP from XMP
HLB40_RS24185	COG1570	exodeoxyribonuclease VII activity
HLB40_RS24190	COG0739	heme binding
HLB40_RS24195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB40_RS24210	COG0436	Aminotransferase
HLB40_RS24215	COG1160	GTP binding
HLB40_RS24230	COG0124	histidyl-tRNA synthetase
HLB40_RS24235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLB40_RS24240	COG1426	Protein conserved in bacteria
HLB40_RS24250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HLB40_RS24255	COG0105	UTP biosynthetic process
HLB40_RS24265	COG0633	Ferredoxin
HLB40_RS24270	COG0443	Heat shock 70 kDa protein
HLB40_RS24275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HLB40_RS24290	COG1104	cysteine desulfurase activity
HLB40_RS24300	COG1045	serine acetyltransferase
HLB40_RS24315	COG3134	Outer membrane lipoprotein
HLB40_RS24330	COG1862	Preprotein translocase
HLB40_RS24335	COG0343	queuine tRNA-ribosyltransferase activity
HLB40_RS24340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLB40_RS24365	COG2853	Lipoprotein
HLB40_RS24415	COG0586	Pfam SNARE associated Golgi protein
HLB40_RS24420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB40_RS24470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB40_RS24485	COG5322	oxidoreductase activity
HLB40_RS24485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB40_RS24495	COG2771	luxR family
HLB40_RS24520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLB40_RS24535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLB40_RS24540	COG0109	protoheme IX farnesyltransferase activity
HLB40_RS24550	COG1845	cytochrome c oxidase, subunit III
HLB40_RS24555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB40_RS24560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLB40_RS24565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLB40_RS24575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB40_RS24575	COG1017	nitric oxide dioxygenase activity
HLB40_RS24585	COG0784	Response regulator, receiver
HLB40_RS24585	COG0835	chemotaxis
HLB40_RS24615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB40_RS24625	COG5002	protein histidine kinase activity
HLB40_RS24640	COG4251	negative regulation of phosphorylation
HLB40_RS24640	COG5001	Diguanylate cyclase
HLB40_RS24640	COG3706	GGDEF domain
HLB40_RS24640	COG2203	Gaf domain
HLB40_RS24645	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HLB40_RS24650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLB40_RS24665	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB40_RS24670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLB40_RS24675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLB40_RS24680	COG0772	Belongs to the SEDS family
HLB40_RS24685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLB40_RS24690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB40_RS24695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLB40_RS24700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLB40_RS24715	COG0275	rRNA processing
HLB40_RS24720	COG2001	Belongs to the MraZ family
HLB40_RS24735	COG3107	peptidoglycan biosynthetic process
HLB40_RS24740	COG0792	nuclease activity
HLB40_RS24745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HLB40_RS24750	COG2823	Periplasmic or secreted lipoprotein
HLB40_RS24755	COG2969	positive regulation of protein catabolic process
HLB40_RS24760	COG0625	glutathione transferase activity
HLB40_RS24765	COG2857	Cytochrome c1
HLB40_RS24770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLB40_RS24775	COG0723	plastoquinol--plastocyanin reductase activity
HLB40_RS24780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLB40_RS24785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLB40_RS24790	COG0667	Aldo Keto reductase
HLB40_RS24795	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS24805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLB40_RS24810	COG0180	Tryptophanyl-tRNA synthetase
HLB40_RS24830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB40_RS24845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HLB40_RS24855	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS24885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB40_RS24895	COG2771	luxR family
HLB40_RS24900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB40_RS24915	COG0745	RESPONSE REGULATOR receiver
HLB40_RS24920	COG0642	Histidine kinase
HLB40_RS24925	COG2909	trisaccharide binding
HLB40_RS24940	COG0318	PFAM AMP-dependent synthetase and ligase
HLB40_RS24960	COG1280	lysine exporter protein (LysE YggA)
HLB40_RS24965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB40_RS24970	COG2813	Specifically methylates the guanine in position
HLB40_RS24975	COG2119	membrane
HLB40_RS24980	COG0501	Belongs to the peptidase M48B family
HLB40_RS24985	COG0840	transmembrane signaling receptor activity
HLB40_RS24990	COG2135	peptidase activity
HLB40_RS25050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HLB40_RS25055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLB40_RS25065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLB40_RS25070	COG1090	epimerase
HLB40_RS25075	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HLB40_RS25085	COG0789	Transcriptional regulator
HLB40_RS25090	COG0415	Belongs to the DNA photolyase family
HLB40_RS25105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLB40_RS25110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB40_RS25120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLB40_RS25125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HLB40_RS25135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HLB40_RS25140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLB40_RS25150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLB40_RS25155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLB40_RS25160	COG0193	aminoacyl-tRNA hydrolase activity
HLB40_RS25165	COG0012	GTP binding
HLB40_RS25170	COG2197	response regulator
HLB40_RS25175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS25175	COG2205	protein histidine kinase activity
HLB40_RS25180	COG3397	chitin binding
HLB40_RS25245	COG2258	MOSC domain
HLB40_RS25270	COG2223	nitrite transmembrane transporter activity
HLB40_RS25350	COG0405	Gamma-glutamyltransferase
HLB40_RS25365	COG4680	protein conserved in bacteria
HLB40_RS25380	COG0789	Transcriptional regulator
HLB40_RS25395	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB40_RS25410	COG3655	Transcriptional regulator
HLB40_RS25430	COG0662	Cupin 2, conserved barrel domain protein
HLB40_RS25440	COG0583	DNA-binding transcription factor activity
HLB40_RS25445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB40_RS25450	COG1028	Short-chain dehydrogenase reductase Sdr
HLB40_RS25455	COG0583	DNA-binding transcription factor activity
HLB40_RS25525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLB40_RS25540	COG2031	fatty acid transporter
HLB40_RS25555	COG0288	reversible hydration of carbon dioxide
HLB40_RS25565	COG0456	acetyltransferase
HLB40_RS25590	COG3008	intermembrane lipid transfer
HLB40_RS25595	COG2995	paraquat-inducible protein a
HLB40_RS25600	COG2995	paraquat-inducible protein a
HLB40_RS25630	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HLB40_RS25635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB40_RS25640	COG1183	phosphatidylcholine synthase activity
HLB40_RS25645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLB40_RS25655	COG0028	Belongs to the TPP enzyme family
HLB40_RS25675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB40_RS25705	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLB40_RS25710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB40_RS25715	COG4558	Periplasmic binding protein
HLB40_RS25725	COG1489	DNA binding
HLB40_RS25730	COG0436	Aminotransferase
HLB40_RS25740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLB40_RS25750	COG4191	Histidine kinase
HLB40_RS25770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLB40_RS25775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLB40_RS25785	COG0166	Belongs to the GPI family
HLB40_RS25790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB40_RS25805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB40_RS25815	COG2823	Periplasmic or secreted lipoprotein
HLB40_RS25830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLB40_RS25835	COG0237	dephospho-CoA kinase activity
HLB40_RS25840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HLB40_RS25860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB40_RS25915	COG0728	peptidoglycan biosynthetic process
HLB40_RS25930	COG1252	NADH dehydrogenase
HLB40_RS25940	COG3121	Chaperone
HLB40_RS25945	COG3188	usher protein
HLB40_RS25975	COG0542	response to heat
HLB40_RS26005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS26045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLB40_RS26050	COG1047	Peptidyl-prolyl cis-trans
HLB40_RS26055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLB40_RS26060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLB40_RS26065	COG0196	riboflavin kinase activity
HLB40_RS26075	COG0268	Binds directly to 16S ribosomal RNA
HLB40_RS26080	COG3045	CreA protein
HLB40_RS26085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HLB40_RS26090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLB40_RS26095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLB40_RS26100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLB40_RS26105	COG0142	geranyltranstransferase activity
HLB40_RS26110	COG2824	Alkylphosphonate utilization operon protein PhnA
HLB40_RS26115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLB40_RS26120	COG0545	Peptidyl-prolyl cis-trans isomerase
HLB40_RS26130	COG2862	Uncharacterized protein family, UPF0114
HLB40_RS26145	COG1067	ATP-dependent peptidase activity
HLB40_RS26165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLB40_RS26175	COG0488	(ABC) transporter
HLB40_RS26185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLB40_RS26195	COG2186	Transcriptional regulator
HLB40_RS26205	COG0523	cobalamin synthesis protein
HLB40_RS26210	COG2879	small protein
HLB40_RS26215	COG1966	Carbon starvation protein
HLB40_RS26220	COG2020	methyltransferase activity
HLB40_RS26250	COG1970	mechanosensitive ion channel activity
HLB40_RS26260	COG2813	Specifically methylates the guanine in position
HLB40_RS26270	COG1294	oxidase, subunit
HLB40_RS26275	COG1271	oxidase subunit
HLB40_RS26290	COG3093	addiction module antidote protein HigA
HLB40_RS26305	COG2252	PERMEase
HLB40_RS26310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLB40_RS26315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLB40_RS26320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLB40_RS26325	COG3135	benzoate transporter
HLB40_RS26335	COG1309	transcriptional regulator
HLB40_RS26340	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HLB40_RS26340	COG1082	Xylose isomerase domain protein TIM barrel
HLB40_RS26360	COG0673	inositol 2-dehydrogenase activity
HLB40_RS26370	COG1053	succinate dehydrogenase
HLB40_RS26375	COG3485	protocatechuate 3,4-dioxygenase
HLB40_RS26380	COG3485	protocatechuate 3,4-dioxygenase
HLB40_RS26385	COG0583	DNA-binding transcription factor activity
HLB40_RS26390	COG2321	neutral zinc metallopeptidase
HLB40_RS26405	COG1946	Acyl-CoA thioesterase
HLB40_RS26415	COG0123	including yeast histone deacetylase and acetoin utilization protein
HLB40_RS26425	COG0513	Belongs to the DEAD box helicase family
HLB40_RS26435	COG0697	spore germination
HLB40_RS26440	COG1522	sequence-specific DNA binding
HLB40_RS26445	COG1199	ATP-dependent helicase activity
HLB40_RS26445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLB40_RS26455	COG3416	Protein conserved in bacteria
HLB40_RS26470	COG1643	Atp-dependent helicase
HLB40_RS26490	COG1522	sequence-specific DNA binding
HLB40_RS26505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLB40_RS26510	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS26515	COG2198	Histidine kinase
HLB40_RS26515	COG0784	Response regulator, receiver
HLB40_RS26515	COG2205	protein histidine kinase activity
HLB40_RS26520	COG0351	phosphomethylpyrimidine kinase
HLB40_RS26525	COG0352	thiamine-phosphate diphosphorylase activity
HLB40_RS26530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLB40_RS26545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB40_RS26550	COG1702	phosphate starvation-inducible protein PhoH
HLB40_RS26555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLB40_RS26560	COG4535	Mg2 and Co2 transporter CorC
HLB40_RS26565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HLB40_RS26580	COG0495	leucyl-tRNA aminoacylation
HLB40_RS26600	COG2951	lytic endotransglycosylase activity
HLB40_RS26605	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB40_RS26610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLB40_RS26615	COG0321	lipoyl(octanoyl) transferase activity
HLB40_RS26620	COG2921	Belongs to the UPF0250 family
HLB40_RS26625	COG1686	Belongs to the peptidase S11 family
HLB40_RS26635	COG2951	lytic endotransglycosylase activity
HLB40_RS26640	COG0772	Belongs to the SEDS family
HLB40_RS26645	COG0768	penicillin binding
HLB40_RS26650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HLB40_RS26660	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLB40_RS26665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HLB40_RS26670	COG2094	Belongs to the DNA glycosylase MPG family
HLB40_RS26675	COG0586	Pfam SNARE associated Golgi protein
HLB40_RS26685	COG1346	cytolysis
HLB40_RS26705	COG0702	epimerase
HLB40_RS26720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLB40_RS26725	COG3284	Transcriptional regulator
HLB40_RS26735	COG0531	amino acid
HLB40_RS26740	COG4303	Ethanolamine ammonia lyase large subunit
HLB40_RS26745	COG4302	ethanolamine ammonia-lyase activity
HLB40_RS26750	COG0456	acetyltransferase
HLB40_RS26755	COG0586	Pfam SNARE associated Golgi protein
HLB40_RS26760	COG3228	Belongs to the MtfA family
HLB40_RS26765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLB40_RS26780	COG2070	2-Nitropropane dioxygenase
HLB40_RS26790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB40_RS26795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS26800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLB40_RS26805	COG0473	3-isopropylmalate dehydrogenase activity
HLB40_RS26805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLB40_RS26810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB40_RS26820	COG2814	Major facilitator Superfamily
HLB40_RS26835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS26850	COG0583	DNA-binding transcription factor activity
HLB40_RS26860	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB40_RS26865	COG3657	addiction module killer protein
HLB40_RS26875	COG0604	alcohol dehydrogenase
HLB40_RS26875	COG3321	synthase
HLB40_RS26880	COG0640	Transcriptional regulator
HLB40_RS26895	COG1722	exodeoxyribonuclease VII activity
HLB40_RS26900	COG0142	geranyltranstransferase activity
HLB40_RS26905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLB40_RS26910	COG4206	TonB-dependent receptor
HLB40_RS26915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB40_RS26925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLB40_RS26935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLB40_RS26945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLB40_RS26950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLB40_RS26965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB40_RS26965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB40_RS26970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLB40_RS26980	COG2264	protein methyltransferase activity
HLB40_RS26985	COG3118	belongs to the thioredoxin family
HLB40_RS27015	COG3047	cAMP biosynthetic process
HLB40_RS27030	COG1201	RNA secondary structure unwinding
HLB40_RS27035	COG2814	Major facilitator Superfamily
HLB40_RS27045	COG3568	Endonuclease Exonuclease Phosphatase
HLB40_RS27050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB40_RS27055	COG0392	lysyltransferase activity
HLB40_RS27075	COG1335	isochorismatase
HLB40_RS27080	COG0629	single-stranded DNA binding
HLB40_RS27085	COG2814	Major facilitator Superfamily
HLB40_RS27090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB40_RS27095	COG2193	ferroxidase activity
HLB40_RS27105	COG0203	ribosomal protein L17
HLB40_RS27110	COG0202	RNA polymerase activity
HLB40_RS27115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLB40_RS27120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLB40_RS27125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLB40_RS27130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLB40_RS27140	COG0200	Binds to the 23S rRNA
HLB40_RS27145	COG1841	ribosomal large subunit assembly
HLB40_RS27150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLB40_RS27155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLB40_RS27160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLB40_RS27165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLB40_RS27170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLB40_RS27175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLB40_RS27180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HLB40_RS27185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLB40_RS27190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HLB40_RS27195	COG0255	Belongs to the universal ribosomal protein uL29 family
HLB40_RS27200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLB40_RS27205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLB40_RS27210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLB40_RS27215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLB40_RS27220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLB40_RS27225	COG0089	rRNA binding
HLB40_RS27230	COG0088	Forms part of the polypeptide exit tunnel
HLB40_RS27235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLB40_RS27240	COG0051	transcription antitermination factor activity, RNA binding
HLB40_RS27245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLB40_RS27250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLB40_RS27255	COG0049	tRNA binding
HLB40_RS27260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLB40_RS27265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLB40_RS27270	COG0085	RNA polymerase activity
HLB40_RS27275	COG0222	ribosome binding
HLB40_RS27280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLB40_RS27285	COG0081	regulation of translation
HLB40_RS27290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLB40_RS27310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLB40_RS27335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HLB40_RS27370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLB40_RS27375	COG0739	heme binding
HLB40_RS27380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLB40_RS27385	COG0316	Belongs to the HesB IscA family
HLB40_RS27390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLB40_RS27395	COG1981	membrane
HLB40_RS27410	COG4221	oxidoreductase activity
HLB40_RS27415	COG0537	adenosine 5'-monophosphoramidase activity
HLB40_RS27420	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HLB40_RS27425	COG1765	OsmC-like protein
HLB40_RS27440	COG0134	indole-3-glycerol-phosphate synthase activity
HLB40_RS27445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLB40_RS27450	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB40_RS27460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB40_RS27465	COG0546	phosphoglycolate phosphatase activity
HLB40_RS27470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLB40_RS27475	COG1454	alcohol dehydrogenase
HLB40_RS27485	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB40_RS27495	COG3842	ATPase activity
HLB40_RS27500	COG2197	response regulator
HLB40_RS27505	COG4585	Histidine kinase
HLB40_RS27515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HLB40_RS27520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLB40_RS27525	COG3178	'Phosphotransferase
HLB40_RS27530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HLB40_RS27535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB40_RS27540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLB40_RS27545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLB40_RS27550	COG2967	ApaG domain
HLB40_RS27555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB40_RS27560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB40_RS27565	COG2766	serine protein kinase
HLB40_RS27570	COG2718	Belongs to the UPF0229 family
HLB40_RS27575	COG2719	SpoVR family
HLB40_RS27580	COG0617	tRNA 3'-terminal CCA addition
HLB40_RS27590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLB40_RS27595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLB40_RS27600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLB40_RS27605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLB40_RS27610	COG0358	DNA primase activity
HLB40_RS27615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLB40_RS27650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLB40_RS27655	COG1025	Belongs to the peptidase M16 family
HLB40_RS27665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLB40_RS27670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HLB40_RS27680	COG0535	radical SAM domain protein
HLB40_RS27705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB40_RS27710	COG2258	MOSC domain
HLB40_RS27715	COG0583	DNA-binding transcription factor activity
HLB40_RS27720	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS27725	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS27730	COG3706	GGDEF domain
HLB40_RS27735	COG1960	acyl-CoA dehydrogenase activity
HLB40_RS27755	COG1073	alpha beta
HLB40_RS27755	COG2226	methyltransferase
HLB40_RS27760	COG0156	8-amino-7-oxononanoate synthase activity
HLB40_RS27765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HLB40_RS27775	COG3585	molybdate ion transport
HLB40_RS27775	COG2005	Transcriptional regulator
HLB40_RS27785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLB40_RS27800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLB40_RS27820	COG1595	DNA-templated transcription, initiation
HLB40_RS27825	COG3712	iron ion homeostasis
HLB40_RS27830	COG4774	siderophore transport
HLB40_RS27850	COG0625	glutathione transferase activity
HLB40_RS27855	COG4452	Inner membrane protein CreD
HLB40_RS27860	COG2205	protein histidine kinase activity
HLB40_RS27865	COG0745	RESPONSE REGULATOR receiver
HLB40_RS27870	COG4067	protein conserved in archaea
HLB40_RS27870	COG0189	ligase activity
HLB40_RS27875	COG0204	Acyl-transferase
HLB40_RS27885	COG1063	alcohol dehydrogenase
HLB40_RS27915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLB40_RS27930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLB40_RS27945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB40_RS27945	COG1017	nitric oxide dioxygenase activity
HLB40_RS27950	COG4638	Rieske (2fe-2S)
HLB40_RS27960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLB40_RS27965	COG2181	nitrate reductase activity
HLB40_RS27965	COG0247	lactate metabolic process
HLB40_RS27970	COG1902	pentaerythritol trinitrate reductase activity
HLB40_RS27970	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLB40_RS28015	COG3246	L-lysine catabolic process to acetate
HLB40_RS28020	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB40_RS28050	COG1760	l-serine dehydratase
HLB40_RS28060	COG4176	ABC-type proline glycine betaine transport system permease component
HLB40_RS28065	COG4175	Glycine betaine
HLB40_RS28070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB40_RS28075	COG1309	transcriptional regulator
HLB40_RS28080	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS28085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HLB40_RS28095	COG0312	modulator of DNA gyrase
HLB40_RS28100	COG0477	Major facilitator Superfamily
HLB40_RS28105	COG0513	Belongs to the DEAD box helicase family
HLB40_RS28110	COG2081	HI0933 family
HLB40_RS28115	COG1289	transmembrane transporter activity
HLB40_RS28125	COG2153	protein acetylation
HLB40_RS28135	COG1451	nucleotide metabolic process
HLB40_RS28165	COG0126	phosphoglycerate kinase activity
HLB40_RS28170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLB40_RS28180	COG4106	trans-aconitate 2-methyltransferase activity
HLB40_RS28185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLB40_RS28190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLB40_RS28195	COG1422	Protein of unknown function (DUF1090)
HLB40_RS28220	COG2814	Major facilitator Superfamily
HLB40_RS28235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HLB40_RS28240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLB40_RS28255	COG0513	Belongs to the DEAD box helicase family
HLB40_RS28260	COG2353	YceI-like domain
HLB40_RS28265	COG3038	cytochrome b561
HLB40_RS28275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLB40_RS28300	COG1272	protein, Hemolysin III
HLB40_RS28320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLB40_RS28340	COG3052	prosthetic group binding
HLB40_RS28345	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HLB40_RS28365	COG0643	Histidine kinase
HLB40_RS28365	COG2198	Histidine kinase
HLB40_RS28365	COG0784	Response regulator, receiver
HLB40_RS28390	COG0189	ligase activity
HLB40_RS28400	COG1678	Uncharacterized ACR, COG1678
HLB40_RS28405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLB40_RS28410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLB40_RS28415	COG0540	Belongs to the ATCase OTCase family
HLB40_RS28420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLB40_RS28430	COG0791	NLP P60 protein
HLB40_RS28455	COG1872	DUF167
HLB40_RS28460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB40_RS28465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB40_RS28465	COG2813	Specifically methylates the guanine in position
HLB40_RS28475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLB40_RS28480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB40_RS28490	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HLB40_RS28495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLB40_RS28500	COG2022	thiamine diphosphate biosynthetic process
HLB40_RS28510	COG2363	Small membrane protein
HLB40_RS28515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB40_RS28525	COG2177	Part of the ABC transporter FtsEX involved in
HLB40_RS28530	COG2884	Cell division ATP-binding protein ftsE
HLB40_RS28535	COG0552	protein localization to endoplasmic reticulum
HLB40_RS28540	COG0612	Peptidase, M16
HLB40_RS28545	COG0612	Peptidase, M16
HLB40_RS28550	COG0742	ribosomal rna small subunit methyltransferase
HLB40_RS28585	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HLB40_RS28590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLB40_RS28595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLB40_RS28600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLB40_RS28610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB40_RS28620	COG0129	dihydroxy-acid dehydratase activity
HLB40_RS28630	COG1823	symporter activity
HLB40_RS28645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLB40_RS28660	COG1840	ABC-type Fe3 transport system, periplasmic component
HLB40_RS28665	COG1178	ABC-type Fe3 transport system permease component
HLB40_RS28670	COG3842	ATPase activity
HLB40_RS28675	COG0583	DNA-binding transcription factor activity
HLB40_RS28685	COG0789	Transcriptional regulator
HLB40_RS28690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLB40_RS28695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLB40_RS28700	COG0730	response to heat
HLB40_RS28710	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HLB40_RS28715	COG0494	nUDIX hydrolase
HLB40_RS28730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLB40_RS28735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLB40_RS28740	COG2234	aminopeptidase activity
HLB40_RS28745	COG3204	pilus organization
HLB40_RS28750	COG3204	pilus organization
HLB40_RS28755	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB40_RS28760	COG0277	FAD linked oxidase domain protein
HLB40_RS28765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB40_RS28775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS28780	COG1683	Conserved Protein
HLB40_RS28810	COG1177	transmembrane transport
HLB40_RS28815	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB40_RS28820	COG3842	ATPase activity
HLB40_RS28840	COG0174	glutamine synthetase
HLB40_RS28845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLB40_RS28850	COG0174	glutamine synthetase
HLB40_RS28865	COG1116	anion transmembrane transporter activity
HLB40_RS28870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB40_RS28875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB40_RS28880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB40_RS28885	COG0431	NADPH-dependent FMN reductase
HLB40_RS28890	COG0450	alkyl hydroperoxide reductase
HLB40_RS28900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLB40_RS28900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLB40_RS28905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB40_RS28915	COG1522	sequence-specific DNA binding
HLB40_RS28925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLB40_RS28940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLB40_RS28940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLB40_RS28945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLB40_RS28960	COG0509	glycine decarboxylation via glycine cleavage system
HLB40_RS28965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLB40_RS28970	COG1178	ABC-type Fe3 transport system permease component
HLB40_RS28980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLB40_RS28985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLB40_RS28990	COG0006	proline dipeptidase activity
HLB40_RS28995	COG3079	Belongs to the UPF0149 family
HLB40_RS29015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLB40_RS29030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLB40_RS29035	COG0842	Transport permease protein
HLB40_RS29035	COG1129	ABC transporter
HLB40_RS29040	COG0842	Transport permease protein
HLB40_RS29050	COG0604	alcohol dehydrogenase
HLB40_RS29055	COG2271	Major facilitator Superfamily
HLB40_RS29070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLB40_RS29085	COG2186	Transcriptional regulator
HLB40_RS29090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS29095	COG0765	amino acid transport
HLB40_RS29100	COG0765	amino acid transport
HLB40_RS29105	COG1126	abc transporter atp-binding protein
HLB40_RS29110	COG0248	Ppx GppA phosphatase
HLB40_RS29115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLB40_RS29125	COG0586	Pfam SNARE associated Golgi protein
HLB40_RS29135	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HLB40_RS29140	COG1671	Belongs to the UPF0178 family
HLB40_RS29145	COG0672	)-iron permease
HLB40_RS29150	COG1280	lysine exporter protein (LysE YggA)
HLB40_RS29160	COG0488	(ABC) transporter
HLB40_RS29185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLB40_RS29205	COG0181	hydroxymethylbilane synthase activity
HLB40_RS29215	COG0165	Argininosuccinate lyase
HLB40_RS29220	COG0625	glutathione transferase activity
HLB40_RS29235	COG3072	Adenylate cyclase
HLB40_RS29240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLB40_RS29250	COG1965	Belongs to the frataxin family
HLB40_RS29260	COG0019	diaminopimelate decarboxylase activity
HLB40_RS29265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLB40_RS29275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLB40_RS29280	COG1011	Hydrolase
HLB40_RS29290	COG0432	Pfam Uncharacterised protein family UPF0047
HLB40_RS29295	COG0004	ammonium transporteR
HLB40_RS29300	COG0347	Belongs to the P(II) protein family
HLB40_RS29315	COG0529	Catalyzes the synthesis of activated sulfate
HLB40_RS29325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB40_RS29330	COG0574	Belongs to the PEP-utilizing enzyme family
HLB40_RS29330	COG3848	Pyruvate phosphate dikinase
HLB40_RS29335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLB40_RS29340	COG1213	nucleotidyl transferase
HLB40_RS29345	COG0606	chelatase, subunit chli
HLB40_RS29390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLB40_RS29430	COG0583	DNA-binding transcription factor activity
HLB40_RS29435	COG0534	Mate efflux family protein
HLB40_RS29450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB40_RS29455	COG0427	acetyl-CoA hydrolase
HLB40_RS29470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLB40_RS29475	COG0251	oxidation-reduction process
HLB40_RS29480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS29495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB40_RS29505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB40_RS29510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB40_RS29520	COG1012	belongs to the aldehyde dehydrogenase family
HLB40_RS29530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLB40_RS29535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLB40_RS29540	COG0747	negative chemotaxis
HLB40_RS29545	COG2003	Belongs to the UPF0758 family
HLB40_RS29550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLB40_RS29555	COG0756	dUTP diphosphatase activity
HLB40_RS29560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLB40_RS29565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLB40_RS29570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLB40_RS29575	COG0708	Exodeoxyribonuclease III
HLB40_RS29585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLB40_RS29590	COG1561	YicC-like family, N-terminal region
HLB40_RS29595	COG0194	GDP metabolic process
HLB40_RS29600	COG1758	RNA polymerase activity
HLB40_RS29605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLB40_RS29630	COG0848	biopolymer transport protein
HLB40_RS29640	COG0583	DNA-binding transcription factor activity
HLB40_RS29645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLB40_RS29725	COG0515	serine threonine protein kinase
HLB40_RS29765	COG2204	response regulator
HLB40_RS29845	COG3161	chorismate lyase activity
HLB40_RS29850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLB40_RS29870	COG1253	flavin adenine dinucleotide binding
HLB40_RS29875	COG0739	heme binding
HLB40_RS29895	COG0704	Plays a role in the regulation of phosphate uptake
HLB40_RS29900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLB40_RS29905	COG0573	inorganic phosphate transmembrane transporter activity
HLB40_RS29920	COG0477	Major facilitator Superfamily
HLB40_RS29925	COG1607	acyl-coa hydrolase
HLB40_RS29955	COG0583	DNA-binding transcription factor activity
HLB40_RS29960	COG1027	Aspartate ammonia-lyase
HLB40_RS29970	COG1115	amino acid carrier protein
HLB40_RS29975	COG0252	asparaginase activity
HLB40_RS30000	COG2391	methyltransferase activity
HLB40_RS30030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB40_RS30035	COG0765	amino acid transport
HLB40_RS30055	COG5016	pyruvate
HLB40_RS30055	COG0511	ligase activity, forming carbon-carbon bonds
HLB40_RS30060	COG0439	Biotin carboxylase
HLB40_RS30065	COG0583	DNA-binding transcription factor activity
HLB40_RS30085	COG0210	DNA helicase
HLB40_RS30105	COG4651	solute:proton antiporter activity
HLB40_RS30105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLB40_RS30110	COG1607	acyl-coa hydrolase
HLB40_RS30115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HLB40_RS30125	COG0523	cobalamin synthesis protein
HLB40_RS30150	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB40_RS30155	COG1469	GTP cyclohydrolase I activity
HLB40_RS30160	COG1121	(ABC) transporter
HLB40_RS30170	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB40_RS30175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLB40_RS30185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLB40_RS30190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB40_RS30200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB40_RS30205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLB40_RS30210	COG2217	Heavy metal translocating P-type atpase
HLB40_RS30230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLB40_RS30235	COG2267	carboxylic ester hydrolase activity
HLB40_RS30240	COG2453	phosphatase
HLB40_RS30240	COG0671	phosphoesterase, PA-phosphatase related
HLB40_RS30255	COG4589	Belongs to the CDS family
HLB40_RS30260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB40_RS30270	COG1280	lysine exporter protein (LysE YggA)
HLB40_RS30275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB40_RS30280	COG2755	lipolytic protein G-D-S-L family
HLB40_RS30280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HLB40_RS30285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB40_RS30330	COG0438	transferase activity, transferring glycosyl groups
HLB40_RS30345	COG0625	glutathione transferase activity
HLB40_RS30350	COG0583	DNA-binding transcription factor activity
HLB40_RS30355	COG0778	Nitroreductase
HLB40_RS30360	COG0583	DNA-binding transcription factor activity
HLB40_RS30365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLB40_RS30370	COG1349	DNA-binding transcription factor activity
HLB40_RS30375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLB40_RS30380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLB40_RS30385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLB40_RS30390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLB40_RS30395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLB40_RS30400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLB40_RS30405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLB40_RS30415	COG0356	it plays a direct role in the translocation of protons across the membrane
HLB40_RS30420	COG3312	ion transport
HLB40_RS30425	COG1475	DNA binding
HLB40_RS30430	COG1192	Involved in chromosome partitioning
HLB40_RS30435	COG0357	Ribosomal RNA small subunit methyltransferase G
HLB40_RS30440	COG0445	tRNA wobble uridine modification
HLB40_RS30445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLB40_RS30450	COG0706	membrane insertase activity
HLB40_RS30455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLB40_RS30460	COG0594	ribonuclease P activity
HLB40_RS30465	COG0230	Belongs to the bacterial ribosomal protein bL34 family